psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Q92	16.63	Yes	Yes	1	0	6
2	L:L:?1	R:R:K116	11.74	Yes	Yes	1	0	6
3	L:L:?1	R:R:Q119	5.54	Yes	Yes	1	0	7
4	L:L:?1	R:R:M120	5.89	Yes	Yes	1	0	5
5	L:L:?1	R:R:M123	3.92	Yes	No	1	0	7
6	L:L:?1	R:R:Q174	10.16	Yes	Yes	1	0	5
7	L:L:?1	R:R:Y205	3.25	Yes	Yes	1	0	7
8	L:L:?1	R:R:V206	9.31	Yes	No	0	0	5
9	L:L:?1	R:R:I209	6.93	Yes	Yes	1	0	5
10	L:L:?1	R:R:F287	4.23	Yes	Yes	1	0	6
11	L:L:?1	R:R:Q291	16.63	Yes	No	1	0	6
12	L:L:?1	R:R:M311	19.62	Yes	No	0	0	5
13	R:R:L35	R:R:R38	15.79	No	No	0	4	5
14	R:R:E40	R:R:L44	7.95	No	Yes	0	5	7
15	R:R:E40	R:R:V308	8.56	No	No	0	5	4
16	R:R:K100	R:R:L41	4.23	No	No	0	5	4
17	R:R:L312	R:R:L43	6.92	No	No	0	4	5
18	R:R:L44	R:R:L97	6.92	Yes	No	0	7	6
19	R:R:L97	R:R:S45	7.51	No	No	0	6	5
20	R:R:S315	R:R:V47	6.46	No	No	0	7	7
21	R:R:A89	R:R:V51	3.39	No	No	0	7	7
22	R:R:S318	R:R:V51	3.23	No	No	0	9	7
23	R:R:C319	R:R:V51	3.42	Yes	No	0	7	7
24	R:R:P322	R:R:S54	8.91	No	No	0	9	8
25	R:R:S54	R:R:W323	3.71	No	No	0	8	6
26	R:R:C82	R:R:N55	4.72	Yes	Yes	0	9	9
27	R:R:D85	R:R:N55	10.77	No	Yes	0	9	9
28	R:R:L86	R:R:N55	12.36	No	Yes	0	7	9
29	R:R:N55	R:R:P322	4.89	Yes	No	0	9	9
30	R:R:C82	R:R:V58	3.42	Yes	No	0	9	8
31	R:R:P322	R:R:V58	3.53	No	No	0	9	8
32	R:R:C82	R:R:L59	4.76	Yes	No	0	9	7
33	R:R:H75	R:R:L62	6.43	Yes	No	0	9	7
34	R:R:R64	R:R:R68	6.4	No	No	0	6	6
35	R:R:E335	R:R:R64	15.12	No	No	0	6	6
36	R:R:H70	R:R:R65	9.03	No	Yes	0	8	5
37	R:R:H75	R:R:R65	4.51	Yes	Yes	0	9	5
38	R:R:R65	R:R:S331	10.54	Yes	No	0	5	7
39	R:R:E335	R:R:R65	5.82	No	Yes	0	6	5
40	R:R:G69	R:R:H70	4.77	No	No	0	5	8
41	R:R:A72	R:R:H75	8.78	No	Yes	0	7	9
42	R:R:I74	R:R:R137	5.01	No	Yes	0	8	9
43	R:R:H75	R:R:Y325	4.36	Yes	Yes	0	9	9
44	R:R:N157	R:R:V76	8.87	Yes	No	0	4	4
45	R:R:F77	R:R:M133	4.98	Yes	No	0	8	9
46	R:R:D136	R:R:F77	14.33	No	Yes	0	9	8
47	R:R:F77	R:R:N157	7.25	Yes	Yes	3	8	4
48	R:R:F77	R:R:P159	5.78	Yes	Yes	3	8	6
49	R:R:F77	R:R:V160	5.24	Yes	Yes	3	8	7
50	R:R:I78	R:R:Y325	20.55	No	Yes	0	8	9
51	R:R:C82	R:R:G79	3.92	Yes	No	0	9	5
52	R:R:H80	R:R:V160	12.45	No	Yes	0	9	7
53	R:R:L81	R:R:M129	4.24	No	No	0	9	8
54	R:R:D85	R:R:S318	4.42	No	No	0	9	9
55	R:R:D85	R:R:N321	6.73	No	No	0	9	9
56	R:R:A87	R:R:F91	4.16	No	No	0	6	4
57	R:R:Q92	R:R:V88	10.03	Yes	No	0	6	7
58	R:R:S126	R:R:V88	4.85	No	No	0	9	7
59	R:R:F91	R:R:L90	8.53	No	No	0	4	5
60	R:R:F91	R:R:L118	13.4	No	No	0	4	5
61	R:R:Q119	R:R:Q92	3.84	Yes	Yes	1	7	6
62	R:R:M123	R:R:Q92	5.44	No	Yes	1	7	6
63	R:R:L94	R:R:P95	4.93	No	No	0	8	5
64	R:R:A101	R:R:Q96	4.55	No	No	0	4	7
65	R:R:M311	R:R:Q96	5.44	No	No	0	5	7
66	R:R:D103	R:R:W99	4.47	No	No	0	5	5
67	R:R:N182	R:R:R104	6.03	No	No	0	3	4
68	R:R:Q180	R:R:R106	7.01	No	Yes	0	4	3
69	R:R:G107	R:R:P108	4.06	No	No	0	6	8
70	R:R:D109	R:R:R113	21.44	No	No	2	4	7
71	R:R:A179	R:R:D109	4.63	No	No	2	4	4
72	R:R:D109	R:R:Q180	6.53	No	No	0	4	4
73	R:R:C112	R:R:C192	7.28	No	No	1	9	9
74	R:R:A179	R:R:R113	5.53	No	No	2	4	7
75	R:R:Q119	R:R:V115	4.3	Yes	No	0	7	5
76	R:R:K116	R:R:Q119	9.49	Yes	Yes	1	6	7
77	R:R:K116	R:R:Q174	6.78	Yes	Yes	1	6	5
78	R:R:F178	R:R:K116	23.58	Yes	Yes	1	6	6
79	R:R:L168	R:R:Y117	3.52	No	No	0	4	5
80	R:R:L172	R:R:Y117	3.52	No	No	0	4	5
81	R:R:L175	R:R:Y117	5.86	No	No	0	4	5
82	R:R:M120	R:R:M123	4.33	Yes	No	1	5	7
83	R:R:M120	R:R:Y124	5.99	Yes	Yes	1	5	7
84	R:R:M120	R:R:S171	6.13	Yes	No	1	5	7
85	R:R:M120	R:R:Q174	6.8	Yes	Yes	1	5	5
86	R:R:S167	R:R:V121	4.85	No	Yes	0	8	5
87	R:R:L168	R:R:V121	4.47	No	Yes	0	4	5
88	R:R:S171	R:R:V121	3.23	No	Yes	0	7	5
89	R:R:Y124	R:R:Y128	6.95	Yes	Yes	0	7	6
90	R:R:S167	R:R:Y124	3.82	No	Yes	0	8	7
91	R:R:L170	R:R:Y124	7.03	No	Yes	0	4	7
92	R:R:S171	R:R:Y124	7.63	No	Yes	1	7	7
93	R:R:I209	R:R:Y124	4.84	Yes	Yes	1	5	7
94	R:R:V213	R:R:Y124	8.83	No	Yes	0	5	7
95	R:R:A125	R:R:W164	7.78	Yes	No	0	7	9
96	R:R:A125	R:R:S167	3.42	Yes	No	0	7	8
97	R:R:S127	R:R:V213	3.23	No	No	0	8	5
98	R:R:P217	R:R:S127	3.56	No	No	0	9	8
99	R:R:S127	R:R:Y280	3.82	No	Yes	0	8	9
100	R:R:L131	R:R:Y128	3.52	No	Yes	0	7	6
101	R:R:M212	R:R:Y128	3.59	No	Yes	0	3	6
102	R:R:P217	R:R:Y128	6.95	No	Yes	0	9	6
103	R:R:M129	R:R:V160	6.09	No	Yes	0	8	7
104	R:R:I130	R:R:I276	4.42	No	No	0	8	8
105	R:R:I130	R:R:Y280	4.84	No	Yes	0	8	9
106	R:R:I221	R:R:L131	5.71	No	No	0	8	7
107	R:R:I221	R:R:T134	9.12	No	Yes	0	8	8
108	R:R:Q225	R:R:T134	7.09	No	Yes	0	9	8
109	R:R:T134	R:R:T273	3.14	Yes	No	0	8	8
110	R:R:D136	R:R:R137	3.57	No	Yes	0	9	9
111	R:R:D136	R:R:R139	3.57	No	Yes	0	9	5
112	R:R:R137	R:R:T269	11.64	Yes	No	0	9	7
113	R:R:R137	R:R:T273	3.88	Yes	No	0	9	8
114	R:R:C142	R:R:H138	8.85	No	No	0	6	8
115	R:R:H138	R:R:R143	9.03	No	No	0	8	6
116	R:R:H138	R:R:L227	6.43	No	No	0	8	4
117	R:R:A140	R:R:R139	4.15	No	Yes	0	8	5
118	R:R:R139	R:R:R143	5.33	Yes	No	0	5	6
119	R:R:M145	R:R:R139	4.96	No	Yes	0	7	5
120	R:R:E231	R:R:I141	5.47	No	Yes	0	5	8
121	R:R:I141	R:R:I232	4.42	Yes	No	6	8	9
122	R:R:N157	R:R:S152	4.47	Yes	No	0	4	7
123	R:R:G153	R:R:W156	9.85	No	No	0	4	7
124	R:R:A154	R:R:H155	7.32	No	No	0	4	4
125	R:R:L161	R:R:W156	9.11	No	No	0	2	7
126	R:R:N157	R:R:P159	11.4	Yes	Yes	3	4	6
127	R:R:N157	R:R:V160	8.87	Yes	Yes	3	4	7
128	R:R:L170	R:R:W208	3.42	No	Yes	0	4	3
129	R:R:P173	R:R:Y205	4.17	No	Yes	0	8	7
130	R:R:F178	R:R:Q174	4.68	Yes	Yes	1	6	5
131	R:R:Q174	R:R:Y205	7.89	Yes	Yes	1	5	7
132	R:R:F196	R:R:I177	3.77	No	No	0	5	5
133	R:R:I177	R:R:Y205	7.25	No	Yes	0	5	7
134	R:R:A194	R:R:F178	8.32	No	Yes	0	5	6
135	R:R:R181	R:R:W193	10	No	No	2	1	4
136	R:R:C195	R:R:R181	8.36	No	No	2	2	1
137	R:R:C195	R:R:W193	3.92	No	No	2	2	4
138	R:R:F196	R:R:R202	10.69	No	No	0	5	4
139	R:R:A197	R:R:P199	3.74	No	No	0	5	3
140	R:R:R203	R:R:W200	7	Yes	No	0	4	1
141	R:R:R202	R:R:V206	5.23	No	No	0	4	5
142	R:R:R203	R:R:T204	3.88	Yes	No	0	4	3
143	R:R:R203	R:R:T207	5.17	Yes	No	4	4	5
144	R:R:R203	R:R:W296	18.99	Yes	No	4	4	4
145	R:R:W208	R:R:Y205	3.86	Yes	Yes	1	3	7
146	R:R:I209	R:R:Y205	3.63	Yes	Yes	1	5	7
147	R:R:A295	R:R:V206	5.09	No	No	0	5	5
148	R:R:L292	R:R:T207	4.42	No	No	4	5	5
149	R:R:T207	R:R:W296	7.28	No	No	4	5	4
150	R:R:I209	R:R:W208	3.52	Yes	Yes	1	5	3
151	R:R:M212	R:R:W208	6.98	No	Yes	0	3	3
152	R:R:A210	R:R:L292	3.15	No	No	0	5	5
153	R:R:F288	R:R:V213	6.55	Yes	No	0	7	5
154	R:R:F214	R:R:T218	5.19	No	No	0	8	6
155	R:R:A285	R:R:F214	4.16	No	No	0	6	8
156	R:R:F214	R:R:F288	12.86	No	Yes	0	8	7
157	R:R:T218	R:R:V281	3.17	No	No	0	6	5
158	R:R:I221	R:R:V277	4.61	No	No	0	8	8
159	R:R:L274	R:R:Q225	9.32	No	No	0	5	9
160	R:R:R230	R:R:V226	3.92	No	No	0	4	3
161	R:R:I228	R:R:V270	4.61	No	No	0	8	6
162	R:R:F229	R:R:V270	3.93	No	No	0	5	6
163	R:R:K268	R:R:R271	3.71	No	No	0	8	7
164	R:R:F328	R:R:R271	6.41	Yes	No	0	7	7
165	R:R:M272	R:R:Y325	5.99	No	Yes	0	8	9
166	R:R:F328	R:R:M272	9.95	Yes	No	0	7	8
167	R:R:I324	R:R:V275	6.14	Yes	No	0	8	6
168	R:R:F328	R:R:V275	5.24	Yes	No	0	7	6
169	R:R:I276	R:R:N321	4.25	No	No	0	8	9
170	R:R:I276	R:R:I324	4.42	No	Yes	0	8	8
171	R:R:I324	R:R:V279	4.61	Yes	No	0	8	6
172	R:R:W284	R:R:Y280	12.54	Yes	Yes	1	8	9
173	R:R:N317	R:R:Y280	6.98	Yes	Yes	1	9	9
174	R:R:C283	R:R:L313	3.17	No	No	0	8	7
175	R:R:C283	R:R:N317	3.15	No	Yes	0	8	9
176	R:R:F287	R:R:W284	7.02	Yes	Yes	1	6	8
177	R:R:F288	R:R:W284	8.02	Yes	Yes	1	7	8
178	R:R:A314	R:R:W284	9.08	No	Yes	0	7	8
179	R:R:N317	R:R:W284	6.78	Yes	Yes	1	9	8
180	R:R:L313	R:R:P286	4.93	No	No	0	7	9
181	R:R:F287	R:R:F288	6.43	Yes	Yes	1	6	7
182	R:R:F287	R:R:Q291	5.86	Yes	No	1	6	6
183	R:R:L310	R:R:V290	5.96	No	No	0	5	5
184	R:R:L292	R:R:W296	3.42	No	No	4	5	4
185	R:R:D297	R:R:W293	3.35	No	Yes	0	3	5
186	R:R:L302	R:R:W293	6.83	No	Yes	0	3	5
187	R:R:D297	R:R:P298	8.05	No	No	0	3	3
188	R:R:E299	R:R:L302	5.3	No	No	0	2	3
189	R:R:E303	R:R:F307	12.83	No	No	0	4	5
190	R:R:F307	R:R:P306	5.78	No	No	0	5	4
191	R:R:L309	R:R:V308	4.47	No	No	0	4	4
192	R:R:N317	R:R:N321	9.54	Yes	No	0	9	9
193	R:R:S329	R:R:Y325	7.63	No	Yes	5	8	9
194	R:R:V332	R:R:Y325	11.36	No	Yes	5	8	9
195	R:R:A326	R:R:L336	3.15	No	No	0	7	6
196	R:R:S329	R:R:S331	3.26	No	No	0	8	7
197	R:R:S329	R:R:V332	6.46	No	No	5	8	8
198	R:R:I141	R:R:V266	3.07	Yes	No	6	8	7
199	R:R:I232	R:R:V266	3.07	No	No	6	9	7
200	R:R:C142	R:R:E231	3.04	No	No	0	6	5
201	R:R:I324	R:R:T320	3.04	Yes	No	0	8	6
202	R:R:G107	R:R:R106	3	No	Yes	0	6	3
203	R:R:L44	R:R:V93	2.98	Yes	No	0	7	7
204	R:R:L53	R:R:V49	2.98	No	No	0	4	5
205	R:R:L111	R:R:V115	2.98	No	No	0	5	5
206	R:R:L219	R:R:V215	2.98	No	No	0	3	4
207	R:R:L282	R:R:V278	2.98	No	No	0	5	4
208	R:R:L336	R:R:V332	2.98	No	No	0	6	8
209	R:R:I141	R:R:I228	2.94	Yes	No	0	8	8
210	R:R:P159	R:R:R158	2.88	Yes	No	0	6	3
211	R:R:L211	R:R:M212	2.83	No	No	0	5	3
212	R:R:C192	R:R:R106	2.79	No	Yes	0	9	3
213	R:R:C112	R:R:F178	2.79	No	Yes	1	9	6
214	R:R:C192	R:R:F178	2.79	No	Yes	1	9	6
215	R:R:L41	R:R:L97	2.77	No	No	0	4	6
216	R:R:L312	R:R:L44	2.77	No	Yes	0	4	7
217	R:R:L131	R:R:L135	2.77	No	No	0	7	6
218	R:R:L44	R:R:Q96	2.66	Yes	No	0	7	7
219	R:R:F48	R:R:V93	2.62	No	No	0	6	7
220	R:R:F166	R:R:V162	2.62	No	No	0	3	3
221	R:R:F307	R:R:V290	2.62	No	No	0	5	5
222	R:R:A294	R:R:W293	2.59	No	Yes	0	4	5
223	R:R:F48	R:R:L94	2.44	No	No	0	6	8
224	R:R:F166	R:R:L170	2.44	No	No	0	3	4
225	R:R:F287	R:R:L310	2.44	Yes	No	0	6	5
226	R:R:L83	R:R:W164	2.28	No	No	0	6	9
227	R:R:R67	R:R:R68	2.13	No	No	0	6	6
228	R:R:G304	R:R:P306	2.03	No	No	0	4	4
229	R:R:R202	R:R:W200	2	No	No	0	4	1
230	R:R:A125	R:R:G122	1.95	Yes	No	0	7	8
231	R:R:A305	R:R:G304	1.95	No	No	0	2	4
232	R:R:A72	R:R:P73	1.87	No	No	0	7	7
233	R:R:A132	R:R:P159	1.87	No	Yes	0	7	6
234	R:R:A216	R:R:P217	1.87	No	No	0	5	9
235	R:R:A300	R:R:P301	1.87	No	No	0	1	4
236	R:R:G153	R:R:S152	1.86	No	No	0	4	7
237	R:R:A50	R:R:C319	1.81	No	Yes	0	6	7
238	R:R:A125	R:R:A84	1.79	Yes	No	0	7	8
239	R:R:A294	R:R:A300	1.79	No	No	0	4	1
240	R:R:C319	R:R:V47	1.71	Yes	No	0	7	7
241	R:R:G220	R:R:L219	1.71	No	No	0	6	3
242	R:R:G56	R:R:N55	1.7	No	Yes	0	3	9
243	R:R:C224	R:R:T134	1.69	No	Yes	0	5	8
244	R:R:S330	R:R:S333	1.63	No	No	0	5	8
245	R:R:A163	R:R:M129	1.61	No	No	0	7	8
246	R:R:C283	R:R:L316	1.59	No	No	0	8	6
247	R:R:C319	R:R:L316	1.59	Yes	No	0	7	6
248	R:R:A37	R:R:L35	1.58	No	No	0	5	4
249	R:R:A52	R:R:L53	1.58	No	No	0	5	4
250	R:R:A61	R:R:L336	1.58	No	No	0	7	6
251	R:R:A285	R:R:L289	1.58	No	No	0	6	5
252	R:R:E198	R:R:P199	1.57	No	No	0	4	3
253	R:R:I46	R:R:V47	1.54	No	No	0	4	7
254	R:R:F196	R:R:G201	1.51	No	No	0	5	3
255	R:R:L118	R:R:V121	1.49	No	Yes	0	5	5
256	R:R:L274	R:R:V278	1.49	No	No	0	5	4
257	R:R:L282	R:R:V281	1.49	No	No	0	5	5
258	R:R:D191	R:R:T102	1.45	No	No	0	4	5
259	R:R:P144	R:R:R143	1.44	No	No	0	9	6
260	R:R:G66	R:R:W71	1.41	No	No	0	8	7
261	R:R:L53	R:R:L57	1.38	No	No	0	4	5
262	R:R:L169	R:R:L172	1.38	No	No	0	4	4
263	R:R:A179	R:R:R181	1.38	No	No	2	4	1
264	R:R:P73	R:R:W71	1.35	No	No	0	7	7
265	R:R:D103	R:R:D191	1.33	No	No	0	5	4
266	R:R:F328	R:R:S327	1.32	Yes	No	0	7	5
267	R:R:F48	R:R:V49	1.31	No	No	0	6	5
268	R:R:A154	R:R:W71	1.3	No	No	0	4	7
269	R:R:F176	R:R:I177	1.26	No	No	0	4	5
270	R:R:V290	R:R:W293	1.23	No	Yes	0	5	5
271	R:R:R104	R:R:R106	1.07	No	Yes	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.4875	12	1	0
2	R:R:L44	4.656	5	0	7
3	R:R:N55	6.888	5	0	9
4	R:R:R65	7.475	4	0	5
5	R:R:H75	6.02	4	0	9
6	R:R:F77	7.516	5	3	8
7	R:R:C82	4.205	4	0	9
8	R:R:Q92	8.985	4	1	6
9	R:R:R106	3.4675	4	0	3
10	R:R:K116	12.8975	4	1	6
11	R:R:Q119	5.7925	4	1	7
12	R:R:M120	5.828	5	1	5
13	R:R:V121	3.51	4	0	5
14	R:R:Y124	6.44143	7	1	7
15	R:R:A125	3.735	4	0	7
16	R:R:Y128	5.2525	4	0	6
17	R:R:T134	5.26	4	0	8
18	R:R:R137	6.025	4	0	9
19	R:R:R139	4.5025	4	0	5
20	R:R:I141	3.975	4	6	8
21	R:R:N157	8.172	5	3	4
22	R:R:P159	5.4825	4	3	6
23	R:R:V160	8.1625	4	3	7
24	R:R:Q174	7.262	5	1	5
25	R:R:F178	8.432	5	1	6
26	R:R:R203	8.76	4	4	4
27	R:R:Y205	5.00833	6	1	7
28	R:R:W208	4.445	4	1	3
29	R:R:I209	4.73	4	1	5
30	R:R:Y280	7.045	4	1	9
31	R:R:W284	8.688	5	1	8
32	R:R:F287	5.196	5	1	6
33	R:R:F288	8.465	4	1	7
34	R:R:W293	3.5	4	0	5
35	R:R:N317	6.6125	4	1	9
36	R:R:C319	2.1325	4	0	7
37	R:R:I324	4.5525	4	0	8
38	R:R:Y325	9.978	5	5	9
39	R:R:F328	5.73	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:M311	53.0976	19.62	Yes	No	0	0	5
2	R:R:M311	R:R:Q96	50.9444	5.44	No	No	0	5	7
3	R:R:L44	R:R:Q96	46.4361	2.66	Yes	No	0	7	7
4	R:R:L44	R:R:L97	10.8201	6.92	Yes	No	0	7	6
5	L:L:?1	R:R:F287	100	4.23	Yes	Yes	1	0	6
6	R:R:F287	R:R:W284	80.7384	7.02	Yes	Yes	1	6	8
7	R:R:N317	R:R:W284	63.0393	6.78	Yes	Yes	1	9	8
8	R:R:C283	R:R:N317	23.4435	3.15	No	Yes	0	8	9
9	R:R:C283	R:R:L316	16.9141	1.59	No	No	0	8	6
10	R:R:C319	R:R:L316	14.8076	1.59	Yes	No	0	7	6
11	R:R:N317	R:R:N321	61.6557	9.54	Yes	No	0	9	9
12	R:R:D85	R:R:N321	33.8904	6.73	No	No	0	9	9
13	R:R:D85	R:R:N55	24.7882	10.77	No	Yes	0	9	9
14	R:R:W284	R:R:Y280	31.7761	12.54	Yes	Yes	1	8	9
15	R:R:I130	R:R:Y280	52.4524	4.84	No	Yes	0	8	9
16	R:R:I130	R:R:I276	51.1776	4.42	No	No	0	8	8
17	R:R:I276	R:R:I324	85.1691	4.42	No	Yes	0	8	8
18	R:R:I324	R:R:V275	77.8002	6.14	Yes	No	0	8	6
19	R:R:F328	R:R:V275	75.274	5.24	Yes	No	0	7	6
20	R:R:F328	R:R:M272	65.3245	9.95	Yes	No	0	7	8
21	R:R:M272	R:R:Y325	62.6895	5.99	No	Yes	0	8	9
22	R:R:H75	R:R:Y325	41.6945	4.36	Yes	Yes	0	9	9
23	R:R:I276	R:R:N321	36.7276	4.25	No	No	0	8	9
24	R:R:H75	R:R:R65	20.0777	4.51	Yes	Yes	0	9	5
25	R:R:E335	R:R:R65	11.5663	5.82	No	Yes	0	6	5
26	R:R:A72	R:R:H75	17.2095	8.78	No	Yes	0	7	9
27	L:L:?1	R:R:M120	34.7765	5.89	Yes	Yes	1	0	5
28	R:R:M120	R:R:Y124	35.9425	5.99	Yes	Yes	1	5	7
29	R:R:Y124	R:R:Y128	70.6724	6.95	Yes	Yes	0	7	6
30	R:R:L131	R:R:Y128	92.2347	3.52	No	Yes	0	7	6
31	R:R:I221	R:R:L131	88.8923	5.71	No	No	0	8	7
32	R:R:I221	R:R:T134	85.2079	9.12	No	Yes	0	8	8
33	R:R:T134	R:R:T273	79.8912	3.14	Yes	No	0	8	8
34	R:R:R137	R:R:T273	78.0956	3.88	Yes	No	0	9	8
35	R:R:D136	R:R:R137	72.8177	3.57	No	Yes	0	9	9
36	R:R:D136	R:R:F77	38.1656	14.33	No	Yes	0	9	8
37	R:R:F77	R:R:N157	14.3179	7.25	Yes	Yes	3	8	4
38	L:L:?1	R:R:I209	29.9417	6.93	Yes	Yes	1	0	5
39	R:R:I209	R:R:Y124	30.0272	4.84	Yes	Yes	1	5	7
40	R:R:F77	R:R:V160	12.3513	5.24	Yes	Yes	3	8	7
41	R:R:M120	R:R:S171	10.6801	6.13	Yes	No	1	5	7
42	R:R:S171	R:R:V121	22.7361	3.23	No	Yes	0	7	5
43	R:R:L118	R:R:V121	14.6055	1.49	No	Yes	0	5	5
44	R:R:F91	R:R:L118	10.9755	13.4	No	No	0	4	5
45	R:R:L44	R:R:V93	21.4458	2.98	Yes	No	0	7	7
46	R:R:F48	R:R:V93	18.8185	2.62	No	No	0	6	7
47	L:L:?1	R:R:K116	22.0521	11.74	Yes	Yes	1	0	6
48	R:R:F178	R:R:K116	20.8317	23.58	Yes	Yes	1	6	6
49	R:R:C192	R:R:F178	41.8888	2.79	No	Yes	1	9	6
50	R:R:C192	R:R:R106	38.8185	2.79	No	Yes	0	9	3
51	L:L:?1	R:R:Q174	20.8706	10.16	Yes	Yes	1	0	5
52	R:R:F178	R:R:Q174	30.2915	4.68	Yes	Yes	1	6	5
53	R:R:Q180	R:R:R106	23.1714	7.01	No	Yes	0	4	3
54	R:R:D109	R:R:Q180	19.9067	6.53	No	No	0	4	4
55	R:R:A179	R:R:D109	13.2997	4.63	No	No	2	4	4
56	R:R:L168	R:R:V121	18.22	4.47	No	Yes	0	4	5
57	R:R:L168	R:R:Y117	14.6055	3.52	No	No	0	4	5
58	R:R:S167	R:R:Y124	27.9129	3.82	No	Yes	0	8	7
59	R:R:V213	R:R:Y124	37.1007	8.83	No	Yes	0	5	7
60	R:R:F287	R:R:F288	14.761	6.43	Yes	Yes	1	6	7
61	R:R:F288	R:R:V213	19.8523	6.55	Yes	No	0	7	5
62	R:R:A125	R:R:S167	12.9732	3.42	Yes	No	0	7	8
63	R:R:S127	R:R:V213	18.7874	3.23	No	No	0	8	5
64	R:R:S127	R:R:Y280	42.4796	3.82	No	Yes	0	8	9
65	R:R:P217	R:R:Y128	26.9724	6.95	No	Yes	0	9	6
66	L:L:?1	R:R:Y205	10.8201	3.25	Yes	Yes	1	0	7
67	R:R:D136	R:R:R139	36.199	3.57	No	Yes	0	9	5
68	R:R:R139	R:R:R143	29.1566	5.33	Yes	No	0	5	6
69	R:R:H138	R:R:R143	24.384	9.03	No	No	0	8	6
70	R:R:C142	R:R:H138	19.5492	8.85	No	No	0	6	8
71	R:R:C142	R:R:E231	17.1084	3.04	No	No	0	6	5
72	R:R:E231	R:R:I141	14.6522	5.47	No	Yes	0	5	8
73	R:R:N157	R:R:S152	10.0972	4.47	Yes	No	0	4	7
74	R:R:A72	R:R:P73	14.3179	1.87	No	No	0	7	7
75	R:R:P73	R:R:W71	11.403	1.35	No	No	0	7	7
76	R:R:I177	R:R:Y205	10.4547	7.25	No	Yes	0	5	7
77	R:R:A179	R:R:R181	10.0194	1.38	No	No	2	4	1
78	L:L:?1	R:R:V206	33.3463	9.31	Yes	No	0	0	5
79	R:R:R202	R:R:V206	28.6281	5.23	No	No	0	4	5
80	R:R:R202	R:R:W200	24.4695	2	No	No	0	4	1
81	R:R:R203	R:R:W200	21.8111	7	Yes	No	0	4	1
82	R:R:F214	R:R:F288	15.6393	12.86	No	Yes	0	8	7
83	R:R:F287	R:R:L310	44.213	2.44	Yes	No	0	6	5
84	R:R:L310	R:R:V290	41.2981	5.96	No	No	0	5	5
85	R:R:V290	R:R:W293	24.0187	1.23	No	Yes	0	5	5
86	R:R:F307	R:R:V290	14.9398	2.62	No	No	0	5	5
87	R:R:V332	R:R:Y325	11.3486	11.36	No	Yes	5	8	9
88	R:R:F48	R:R:V49	10.8434	1.31	No	No	0	6	5
89	R:R:M120	R:R:Q174	10.3925	6.8	Yes	Yes	1	5	5
90	R:R:S167	R:R:V121	13.4085	4.85	No	Yes	0	8	5
91	R:R:S171	R:R:Y124	14.2324	7.63	No	Yes	1	7	7
92	R:R:P217	R:R:S127	25.5422	3.56	No	No	0	9	8
93	R:R:N317	R:R:Y280	17.9168	6.98	Yes	Yes	1	9	9
94	R:R:F288	R:R:W284	15.0408	8.02	Yes	Yes	1	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Q92	16.63	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:K116	11.74	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Q119	5.54	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:M120	5.89	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M123	3.92	1	Yes	No	0	7	0	1
L:L:?1	R:R:Q174	10.16	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y205	3.25	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:V206	9.31	1	Yes	No	0	5	0	1
L:L:?1	R:R:I209	6.93	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F287	4.23	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Q291	16.63	1	Yes	No	0	6	0	1
L:L:?1	R:R:M311	19.62	1	Yes	No	0	5	0	1
R:R:Q92	R:R:V88	10.03	1	Yes	No	6	7	1	2
R:R:Q119	R:R:Q92	3.84	1	Yes	Yes	7	6	1	1
R:R:M123	R:R:Q92	5.44	1	No	Yes	7	6	1	1
R:R:M311	R:R:Q96	5.44	0	No	No	5	7	1	2
R:R:Q119	R:R:V115	4.3	1	Yes	No	7	5	1	2
R:R:K116	R:R:Q119	9.49	1	Yes	Yes	6	7	1	1
R:R:K116	R:R:Q174	6.78	1	Yes	Yes	6	5	1	1
R:R:F178	R:R:K116	23.58	1	Yes	Yes	6	6	2	1
R:R:M120	R:R:M123	4.33	1	Yes	No	5	7	1	1
R:R:M120	R:R:Y124	5.99	1	Yes	Yes	5	7	1	2
R:R:M120	R:R:S171	6.13	1	Yes	No	5	7	1	2
R:R:M120	R:R:Q174	6.8	1	Yes	Yes	5	5	1	1
R:R:S171	R:R:Y124	7.63	1	No	Yes	7	7	2	2
R:R:I209	R:R:Y124	4.84	1	Yes	Yes	5	7	1	2
R:R:P173	R:R:Y205	4.17	0	No	Yes	8	7	2	1
R:R:F178	R:R:Q174	4.68	1	Yes	Yes	6	5	2	1
R:R:Q174	R:R:Y205	7.89	1	Yes	Yes	5	7	1	1
R:R:I177	R:R:Y205	7.25	0	No	Yes	5	7	2	1
R:R:R202	R:R:V206	5.23	0	No	No	4	5	2	1
R:R:W208	R:R:Y205	3.86	1	Yes	Yes	3	7	2	1
R:R:I209	R:R:Y205	3.63	1	Yes	Yes	5	7	1	1
R:R:A295	R:R:V206	5.09	0	No	No	5	5	2	1
R:R:I209	R:R:W208	3.52	1	Yes	Yes	5	3	1	2
R:R:F287	R:R:W284	7.02	1	Yes	Yes	6	8	1	2
R:R:F288	R:R:W284	8.02	1	Yes	Yes	7	8	2	2
R:R:F287	R:R:F288	6.43	1	Yes	Yes	6	7	1	2
R:R:F287	R:R:Q291	5.86	1	Yes	No	6	6	1	1
R:R:F287	R:R:L310	2.44	1	Yes	No	6	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9U81_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.14
Number of Linked Nodes	242
Number of Links	271
Number of Hubs	39
Number of Links mediated by Hubs	144
Number of Communities	6
Number of Nodes involved in Communities	41
Number of Links involved in Communities	59

Path Summary
Number Of Nodes in MetaPath	95
Number Of Links MetaPath	94
Number of Shortest Paths	40561
Length Of Smallest Path	3
Average Path Length	12.9753
Length of Longest Path	32
Minimum Path Strength	1.355
Average Path Strength	5.90155
Maximum Path Strength	18.3133
Minimum Path Correlation	0.7
Average Path Correlation	0.917043
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	47.1196
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.2698
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• regulation of body fluid levels • hemostasis • biological regulation • regulation of biological quality • regulation of tube diameter • multicellular organismal process • regulation of biological process • system process • regulation of tube size • regulation of system process • positive regulation of biological process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • renal system process • transport • homeostatic process • fluid transport • establishment of localization • water transport • renal water transport • localization • multicellular organismal-level homeostasis • chemical homeostasis • renal absorption • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water absorption • renal water homeostasis • regulation of biosynthetic process • regulation of cellular process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • cellular process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • cellular response to stimulus • response to stimulus • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • response to peptide • response to cytokine • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of systemic arterial blood pressure • endocrine process • regulation of systemic arterial blood pressure by vasopressin • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of cell communication • regulation of signaling • positive regulation of signal transduction • positive regulation of intracellular signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • regulation of urine volume • renal water retention • negative regulation of urine volume • developmental process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • telencephalon development • system development • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • positive regulation of systemic arterial blood pressure • positive regulation of blood pressure • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular organelle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • vesicle • endocytic vesicle
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular organelle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • intracellular membrane-bounded organelle • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle • cytoplasm • organelle membrane • cell periphery • plasma membrane • Golgi apparatus • endomembrane system • endosome • perinuclear region of cytoplasm • endoplasmic reticulum
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30518
Sequence	>9U81_nogp_Chain_R L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G H W A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D R F R G P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R P M G S G A H W N R P V L V A W A F S L L L S L P Q L F I F A Q R N D C W A C F A E P W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D P E A P L E G A P F V L L M L L A S L N S C T N P W I Y A S F S S S V S S E L R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	doi.org/10.1126/science.1215904
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	doi.org/10.1126/science.1215904
	7KH0	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	chim(NtGi1-Gs)/β1/γ2	2.8	2021-05-26	doi.org/10.1038/s41422-021-00483-z
	7KH0 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		2.8	2021-05-26	doi.org/10.1038/s41422-021-00483-z
	7BB6	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	Gs/β1/γ2	4.2	2021-06-02	doi.org/10.1126/sciadv.abg5628
	7BB6 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		4.2	2021-06-02	doi.org/10.1126/sciadv.abg5628
	7BB7	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	Gs/β1/γ2	4.4	2021-06-02	doi.org/10.1126/sciadv.abg5628
	7BB7 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		4.4	2021-06-02	doi.org/10.1126/sciadv.abg5628
	7DW9	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	chim(NtGi1-Gs)/β1/γ2	2.6	2021-07-21	doi.org/10.1038/s41422-021-00480-2
	7DW9 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		2.6	2021-07-21	doi.org/10.1038/s41422-021-00480-2
	7R0C	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	Arrestin2	4.73	2022-09-14	doi.org/10.1126/sciadv.abo7761
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9HAP	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	Tolvaptan	-	-	2.5	2025-06-04	doi.org/10.1038/s41467-025-59114-5
	9HB3	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	Mambaquaretin-1	-	-	2.5	2025-06-04	doi.org/10.1038/s41467-025-59114-5
	9V2N	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Macimorelin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.63	2025-07-02	doi.org/10.1038/s41401-025-01606-7
	9V2N (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Macimorelin	-		2.63	2025-07-02	doi.org/10.1038/s41401-025-01606-7
	9U80	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	Conivaptan	-	-	2.94	2025-12-10	10.1038/s41467-025-64735-x
	9U80 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	Conivaptan	-		2.94	2025-12-10	10.1038/s41467-025-64735-x
	9U81	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	Tolvaptan	-	-	3.08	2025-12-10	10.1038/s41467-025-64735-x
	9U81 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	Tolvaptan	-		3.08	2025-12-10	10.1038/s41467-025-64735-x

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.