psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F105	19.97	Yes	Yes	0	0	8
2	L:L:?1	R:R:K116	12.17	Yes	Yes	1	0	6
3	L:L:?1	R:R:F178	6.31	Yes	Yes	1	0	6
4	L:L:?1	R:R:R202	6.29	Yes	No	0	0	4
5	L:L:?1	R:R:Y205	4.05	Yes	Yes	1	0	7
6	L:L:?1	R:R:V206	9	Yes	No	0	0	5
7	L:L:?1	R:R:I209	4.93	Yes	Yes	1	0	5
8	L:L:?1	R:R:F287	3.15	Yes	Yes	1	0	6
9	L:L:?1	R:R:Q291	19.53	Yes	No	1	0	6
10	L:L:?1	R:R:F307	9.46	Yes	No	0	0	5
11	R:R:L35	R:R:R38	7.29	No	No	0	4	5
12	R:R:A39	R:R:L36	3.15	No	No	0	4	4
13	R:R:E40	R:R:L36	13.25	No	No	0	5	4
14	R:R:E40	R:R:V308	5.7	No	No	0	5	4
15	R:R:L41	R:R:L97	5.54	No	No	0	4	6
16	R:R:L41	R:R:W99	4.56	No	No	0	4	5
17	R:R:L312	R:R:L43	4.15	No	No	0	4	5
18	R:R:L44	R:R:L97	5.54	No	No	0	7	6
19	R:R:L312	R:R:V47	7.45	No	No	0	4	7
20	R:R:S315	R:R:V47	3.23	No	No	0	7	7
21	R:R:F48	R:R:L94	8.53	No	No	0	6	8
22	R:R:N55	R:R:V51	4.43	Yes	No	0	9	7
23	R:R:A89	R:R:V51	5.09	No	No	0	7	7
24	R:R:C319	R:R:V51	3.42	No	No	0	7	7
25	R:R:L53	R:R:L57	4.15	No	No	0	4	5
26	R:R:P322	R:R:S54	8.91	Yes	No	0	9	8
27	R:R:S54	R:R:W323	4.94	No	No	0	8	6
28	R:R:C82	R:R:N55	3.15	No	Yes	0	9	9
29	R:R:D85	R:R:N55	12.12	Yes	Yes	3	9	9
30	R:R:L86	R:R:N55	5.49	No	Yes	0	7	9
31	R:R:N55	R:R:P322	13.03	Yes	Yes	3	9	9
32	R:R:P322	R:R:V58	5.3	Yes	No	0	9	8
33	R:R:A61	R:R:V332	3.39	No	No	0	7	8
34	R:R:H75	R:R:L62	9	No	No	0	9	7
35	R:R:L62	R:R:Y325	3.52	No	Yes	0	7	9
36	R:R:R64	R:R:R68	4.26	No	No	0	6	6
37	R:R:E335	R:R:R64	15.12	No	No	0	6	6
38	R:R:H70	R:R:R65	6.77	No	Yes	4	8	5
39	R:R:R65	R:R:S331	7.91	Yes	Yes	4	5	7
40	R:R:R65	R:R:S334	3.95	Yes	No	0	5	5
41	R:R:E335	R:R:R65	5.82	No	Yes	0	6	5
42	R:R:H70	R:R:S331	8.37	No	Yes	4	8	7
43	R:R:H75	R:R:W71	5.29	No	No	0	9	7
44	R:R:G153	R:R:W71	5.63	No	No	0	4	7
45	R:R:P73	R:R:Y148	5.56	No	No	0	7	6
46	R:R:I74	R:R:R137	3.76	No	Yes	0	8	9
47	R:R:N157	R:R:V76	7.39	Yes	No	0	4	4
48	R:R:F77	R:R:M133	3.73	Yes	No	0	8	9
49	R:R:D136	R:R:F77	14.33	Yes	Yes	0	9	8
50	R:R:F77	R:R:N157	7.25	Yes	Yes	2	8	4
51	R:R:F77	R:R:P159	4.33	Yes	No	2	8	6
52	R:R:F77	R:R:V160	5.24	Yes	No	2	8	7
53	R:R:I78	R:R:Y325	20.55	No	Yes	0	8	9
54	R:R:C82	R:R:G79	3.92	No	No	0	9	5
55	R:R:H80	R:R:L83	3.86	Yes	No	0	9	6
56	R:R:H80	R:R:V160	13.84	Yes	No	0	9	7
57	R:R:H80	R:R:W164	5.29	Yes	Yes	0	9	9
58	R:R:L81	R:R:M129	5.65	No	No	0	9	8
59	R:R:L81	R:R:N321	5.49	No	Yes	0	9	9
60	R:R:D85	R:R:S318	7.36	Yes	No	0	9	9
61	R:R:D85	R:R:N321	5.39	Yes	Yes	0	9	9
62	R:R:D85	R:R:P322	3.22	Yes	Yes	3	9	9
63	R:R:S126	R:R:V88	3.23	No	No	0	9	7
64	R:R:S318	R:R:V88	6.46	No	No	0	9	7
65	R:R:F91	R:R:L118	10.96	No	No	0	4	5
66	R:R:Q92	R:R:W284	5.48	No	Yes	0	6	8
67	R:R:M311	R:R:Q92	5.44	No	No	0	5	6
68	R:R:S315	R:R:V93	3.23	No	No	0	7	7
69	R:R:L94	R:R:P95	3.28	No	Yes	0	8	5
70	R:R:P95	R:R:Q96	4.74	Yes	No	1	5	7
71	R:R:P95	R:R:V115	3.53	Yes	No	1	5	5
72	R:R:P95	R:R:Q119	3.16	Yes	Yes	1	5	7
73	R:R:Q119	R:R:Q96	8.96	Yes	No	1	7	7
74	R:R:T102	R:R:W99	7.28	No	No	0	5	5
75	R:R:F105	R:R:T102	10.38	Yes	No	0	8	5
76	R:R:D191	R:R:R104	5.96	No	No	0	4	4
77	R:R:D191	R:R:F105	4.78	No	Yes	0	4	8
78	R:R:C192	R:R:F105	4.19	No	Yes	0	9	8
79	R:R:G107	R:R:P108	4.06	No	No	0	6	8
80	R:R:L111	R:R:P108	3.28	No	No	0	5	8
81	R:R:D109	R:R:R113	7.15	No	No	0	4	7
82	R:R:C112	R:R:C192	7.28	No	No	0	9	9
83	R:R:Q119	R:R:V115	4.3	Yes	No	1	7	5
84	R:R:K116	R:R:Q119	5.42	Yes	Yes	1	6	7
85	R:R:K116	R:R:Q174	6.78	Yes	No	0	6	5
86	R:R:F178	R:R:K116	12.41	Yes	Yes	1	6	6
87	R:R:V121	R:R:Y117	8.83	Yes	Yes	5	5	5
88	R:R:L168	R:R:Y117	5.86	No	Yes	0	4	5
89	R:R:S171	R:R:Y117	7.63	No	Yes	5	7	5
90	R:R:L172	R:R:Y117	5.86	No	Yes	0	4	5
91	R:R:L175	R:R:Y117	7.03	No	Yes	0	4	5
92	R:R:M120	R:R:M123	7.22	Yes	No	0	5	7
93	R:R:M120	R:R:Y124	3.59	Yes	Yes	0	5	7
94	R:R:M120	R:R:S171	4.6	Yes	No	0	5	7
95	R:R:M120	R:R:Q174	9.52	Yes	No	0	5	5
96	R:R:G122	R:R:V121	3.68	No	Yes	0	8	5
97	R:R:S167	R:R:V121	4.85	No	Yes	0	8	5
98	R:R:S171	R:R:V121	3.23	No	Yes	5	7	5
99	R:R:M123	R:R:V213	6.09	No	No	1	7	5
100	R:R:F288	R:R:M123	4.98	Yes	No	1	7	7
101	R:R:Y124	R:R:Y128	4.96	Yes	Yes	1	7	6
102	R:R:L170	R:R:Y124	9.38	No	Yes	1	4	7
103	R:R:I209	R:R:Y124	4.84	Yes	Yes	1	5	7
104	R:R:M212	R:R:Y124	4.79	No	Yes	0	3	7
105	R:R:V213	R:R:Y124	8.83	No	Yes	1	5	7
106	R:R:A125	R:R:W164	5.19	No	Yes	0	7	9
107	R:R:A125	R:R:S167	3.42	No	No	0	7	8
108	R:R:P217	R:R:S127	3.56	No	No	0	9	8
109	R:R:S127	R:R:Y280	6.36	No	Yes	0	8	9
110	R:R:L131	R:R:Y128	4.69	No	Yes	0	7	6
111	R:R:L170	R:R:Y128	3.52	No	Yes	1	4	6
112	R:R:P217	R:R:Y128	8.34	No	Yes	0	9	6
113	R:R:A163	R:R:M129	3.22	No	No	0	7	8
114	R:R:M129	R:R:W164	9.31	No	Yes	0	8	9
115	R:R:I130	R:R:I276	4.42	No	No	0	8	8
116	R:R:I130	R:R:Y280	6.04	No	Yes	0	8	9
117	R:R:I221	R:R:L131	5.71	No	No	0	8	7
118	R:R:M133	R:R:T273	4.52	No	No	0	9	8
119	R:R:I221	R:R:T134	9.12	No	No	0	8	8
120	R:R:Q225	R:R:T134	7.09	No	No	0	9	8
121	R:R:L135	R:R:R139	3.64	No	No	0	6	5
122	R:R:D136	R:R:R137	8.34	Yes	Yes	0	9	9
123	R:R:R137	R:R:T269	7.76	Yes	No	0	9	7
124	R:R:R137	R:R:T273	5.17	Yes	No	0	9	8
125	R:R:C142	R:R:H138	14.74	No	Yes	0	6	8
126	R:R:H138	R:R:L227	7.71	Yes	No	0	8	4
127	R:R:H138	R:R:I228	3.98	Yes	No	0	8	8
128	R:R:A147	R:R:R139	5.53	No	No	0	6	5
129	R:R:I141	R:R:I232	4.42	No	No	0	8	9
130	R:R:I141	R:R:V266	4.61	No	No	0	8	7
131	R:R:C142	R:R:E231	6.08	No	No	0	6	5
132	R:R:H150	R:R:R149	3.39	No	No	0	5	4
133	R:R:H150	R:R:R158	5.64	No	No	0	5	3
134	R:R:A154	R:R:S152	3.42	No	No	0	4	7
135	R:R:S152	R:R:W156	8.65	No	No	0	7	7
136	R:R:N157	R:R:P159	9.77	Yes	No	2	4	6
137	R:R:N157	R:R:V160	7.39	Yes	No	2	4	7
138	R:R:P173	R:R:Y205	5.56	No	Yes	0	8	7
139	R:R:Q174	R:R:Y205	5.64	No	Yes	0	5	7
140	R:R:F176	R:R:L175	4.87	No	No	0	4	4
141	R:R:F178	R:R:I177	3.77	Yes	No	0	6	5
142	R:R:I177	R:R:Y205	3.63	No	Yes	0	5	7
143	R:R:A194	R:R:F178	5.55	No	Yes	0	5	6
144	R:R:C195	R:R:R181	5.57	No	No	0	2	1
145	R:R:F196	R:R:R202	7.48	No	No	0	5	4
146	R:R:R203	R:R:W296	21.99	No	No	0	4	4
147	R:R:W208	R:R:Y205	4.82	No	Yes	1	3	7
148	R:R:I209	R:R:Y205	8.46	Yes	Yes	1	5	7
149	R:R:A295	R:R:V206	5.09	No	No	0	5	5
150	R:R:T207	R:R:W296	3.64	No	No	0	5	4
151	R:R:I209	R:R:W208	5.87	Yes	No	1	5	3
152	R:R:M212	R:R:W208	13.96	No	No	0	3	3
153	R:R:A210	R:R:L292	4.73	No	No	0	5	5
154	R:R:F288	R:R:V213	6.55	Yes	No	1	7	5
155	R:R:F214	R:R:T218	7.78	Yes	No	0	8	6
156	R:R:A285	R:R:F214	4.16	No	Yes	0	6	8
157	R:R:F214	R:R:F288	13.93	Yes	Yes	0	8	7
158	R:R:T218	R:R:V281	3.17	No	No	0	6	5
159	R:R:I221	R:R:V277	4.61	No	No	0	8	8
160	R:R:L274	R:R:Q225	9.32	No	No	0	5	9
161	R:R:I228	R:R:V270	4.61	No	No	0	8	6
162	R:R:F229	R:R:H233	7.92	No	No	0	5	4
163	R:R:F328	R:R:R271	8.55	Yes	No	0	7	7
164	R:R:M272	R:R:Y325	4.79	No	Yes	0	8	9
165	R:R:F328	R:R:M272	11.2	Yes	No	0	7	8
166	R:R:I324	R:R:V275	6.14	No	No	0	8	6
167	R:R:I276	R:R:N321	11.33	No	Yes	0	8	9
168	R:R:I276	R:R:I324	5.89	No	No	0	8	8
169	R:R:W284	R:R:Y280	9.65	Yes	Yes	1	8	9
170	R:R:N317	R:R:Y280	5.81	Yes	Yes	1	9	9
171	R:R:C283	R:R:L313	4.76	No	No	0	8	7
172	R:R:C283	R:R:L316	3.17	No	No	0	8	6
173	R:R:C283	R:R:N317	3.15	No	Yes	0	8	9
174	R:R:F287	R:R:W284	6.01	Yes	Yes	1	6	8
175	R:R:F288	R:R:W284	4.01	Yes	Yes	1	7	8
176	R:R:A314	R:R:W284	10.37	No	Yes	0	7	8
177	R:R:N317	R:R:W284	5.65	Yes	Yes	1	9	8
178	R:R:A285	R:R:L289	3.15	No	No	0	6	5
179	R:R:L313	R:R:P286	3.28	No	No	0	7	9
180	R:R:F287	R:R:F288	11.79	Yes	Yes	1	6	7
181	R:R:F287	R:R:Q291	9.37	Yes	No	1	6	6
182	R:R:Q291	R:R:V290	5.73	No	No	0	6	5
183	R:R:A294	R:R:W293	3.89	No	No	0	4	5
184	R:R:P301	R:R:W293	10.81	No	No	0	4	5
185	R:R:L302	R:R:P301	3.28	No	No	0	3	4
186	R:R:C319	R:R:L316	3.17	No	No	0	7	6
187	R:R:N317	R:R:N321	6.81	Yes	Yes	0	9	9
188	R:R:S329	R:R:Y325	13.99	No	Yes	0	8	9
189	R:R:A326	R:R:V332	3.39	No	No	0	7	8
190	R:R:S329	R:R:S331	3.26	No	Yes	0	8	7
191	R:R:S329	R:R:V332	4.85	No	No	0	8	8
192	R:R:I141	R:R:V270	3.07	No	No	0	8	6
193	R:R:I324	R:R:T320	3.04	No	No	0	8	6
194	R:R:L111	R:R:V115	2.98	No	No	0	5	5
195	R:R:L211	R:R:V215	2.98	No	No	0	5	4
196	R:R:L219	R:R:V215	2.98	No	No	0	3	4
197	R:R:L274	R:R:V278	2.98	No	No	0	5	4
198	R:R:L282	R:R:V281	2.98	No	No	0	5	5
199	R:R:N317	R:R:V279	2.96	Yes	No	0	9	6
200	R:R:C224	R:R:H138	2.95	No	Yes	0	5	8
201	R:R:I74	R:R:I78	2.94	No	No	0	8	8
202	R:R:A72	R:R:H75	2.93	No	No	0	7	9
203	R:R:G66	R:R:W71	2.81	No	No	0	8	7
204	R:R:L312	R:R:L44	2.77	No	No	0	4	7
205	R:R:A52	R:R:F48	2.77	No	No	0	5	6
206	R:R:L59	R:R:L83	2.77	No	No	0	7	6
207	R:R:A132	R:R:F77	2.77	No	Yes	0	7	8
208	R:R:A87	R:R:F91	2.77	No	No	0	6	4
209	R:R:A179	R:R:R113	2.77	No	No	0	4	7
210	R:R:L169	R:R:L172	2.77	No	No	0	4	4
211	R:R:F166	R:R:V162	2.62	No	No	0	3	3
212	R:R:D109	R:R:Q180	2.61	No	No	0	4	4
213	R:R:A84	R:R:W164	2.59	No	Yes	0	8	9
214	R:R:F328	R:R:K268	2.48	Yes	No	0	7	8
215	R:R:F48	R:R:L90	2.44	No	No	0	6	5
216	R:R:F91	R:R:L90	2.44	No	No	0	4	5
217	R:R:L227	R:R:R230	2.43	No	No	0	4	4
218	R:R:D103	R:R:R104	2.38	No	No	0	5	4
219	R:R:D136	R:R:Y148	2.3	Yes	No	0	9	6
220	R:R:L161	R:R:W156	2.28	No	No	0	2	7
221	R:R:H138	R:R:R143	2.26	Yes	No	0	8	6
222	R:R:D191	R:R:W193	2.23	No	No	0	4	4
223	R:R:H150	R:R:W156	2.12	No	No	0	5	7
224	R:R:G304	R:R:P306	2.03	No	No	0	4	4
225	R:R:R181	R:R:W193	2	No	No	0	1	4
226	R:R:A216	R:R:P217	1.87	No	No	0	5	9
227	R:R:A300	R:R:P301	1.87	No	No	0	1	4
228	R:R:A305	R:R:P306	1.87	No	No	0	2	4
229	R:R:G153	R:R:S152	1.86	No	No	0	4	7
230	R:R:G201	R:R:T204	1.82	No	No	0	3	3
231	R:R:A50	R:R:C319	1.81	No	No	0	6	7
232	R:R:A179	R:R:C195	1.81	No	No	0	4	2
233	R:R:A101	R:R:A98	1.79	No	No	0	4	4
234	R:R:A42	R:R:S45	1.71	No	No	0	5	5
235	R:R:G56	R:R:L59	1.71	No	No	0	3	7
236	R:R:C224	R:R:T134	1.69	No	No	0	5	8
237	R:R:L310	R:R:P286	1.64	No	No	0	5	9
238	R:R:S330	R:R:S331	1.63	No	Yes	0	5	7
239	R:R:A37	R:R:L35	1.58	No	No	0	5	4
240	R:R:I46	R:R:S45	1.55	No	No	0	4	5
241	R:R:I46	R:R:V47	1.54	No	No	0	4	7
242	R:R:A110	R:R:D109	1.54	No	No	0	2	4
243	R:R:A140	R:R:D136	1.54	No	Yes	0	8	9
244	R:R:A37	R:R:E40	1.51	No	No	0	5	5
245	R:R:A234	R:R:E231	1.51	No	No	0	4	5
246	R:R:G69	R:R:R68	1.5	No	No	0	5	6
247	R:R:L227	R:R:V226	1.49	No	No	0	4	3
248	R:R:L292	R:R:T207	1.47	No	No	0	5	5
249	R:R:P144	R:R:R143	1.44	No	No	0	9	6
250	R:R:L146	R:R:M145	1.41	No	No	0	5	7
251	R:R:A210	R:R:F288	1.39	No	Yes	0	5	7
252	R:R:L309	R:R:L310	1.38	No	No	0	4	5
253	R:R:F328	R:R:S327	1.32	Yes	No	0	7	5
254	R:R:F214	R:R:V215	1.31	Yes	No	0	8	4
255	R:R:A300	R:R:W296	1.3	No	No	0	1	4
256	R:R:R203	R:R:T204	1.29	No	No	0	4	3
257	R:R:F166	R:R:L170	1.22	No	No	0	3	4
258	R:R:H155	R:R:H80	1.19	No	Yes	0	4	9
259	R:R:R139	R:R:Y148	1.03	No	No	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.486	10	1	0
2	R:R:N55	7.644	5	3	9
3	R:R:R65	6.1125	4	4	5
4	R:R:F77	6.275	6	2	8
5	R:R:H80	6.045	4	0	9
6	R:R:D85	7.0225	4	3	9
7	R:R:P95	3.6775	4	1	5
8	R:R:F105	9.83	4	0	8
9	R:R:K116	9.195	4	1	6
10	R:R:Y117	7.042	5	5	5
11	R:R:Q119	5.46	4	1	7
12	R:R:M120	6.2325	4	0	5
13	R:R:V121	5.1475	4	5	5
14	R:R:Y124	6.065	6	1	7
15	R:R:Y128	5.3775	4	1	6
16	R:R:D136	6.6275	4	0	9
17	R:R:R137	6.2575	4	0	9
18	R:R:H138	6.328	5	0	8
19	R:R:N157	7.95	4	2	4
20	R:R:W164	5.595	4	0	9
21	R:R:F178	7.01	4	1	6
22	R:R:Y205	5.36	6	1	7
23	R:R:I209	6.025	4	1	5
24	R:R:F214	6.795	4	0	8
25	R:R:Y280	6.965	4	1	9
26	R:R:W284	6.86167	6	1	8
27	R:R:F287	7.58	4	1	6
28	R:R:F288	7.10833	6	1	7
29	R:R:N317	4.876	5	1	9
30	R:R:N321	7.255	4	0	9
31	R:R:P322	7.615	4	3	9
32	R:R:Y325	10.7125	4	0	9
33	R:R:F328	5.8875	4	0	7
34	R:R:S331	5.2925	4	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F105	63.6934	19.97	Yes	Yes	0	0	8
2	R:R:F105	R:R:T102	32.5103	10.38	Yes	No	0	8	5
3	R:R:T102	R:R:W99	30.1029	7.28	No	No	0	5	5
4	R:R:L41	R:R:W99	27.6749	4.56	No	No	0	4	5
5	R:R:L41	R:R:L97	25.607	5.54	No	No	0	4	6
6	R:R:L44	R:R:L97	23.1379	5.54	No	No	0	7	6
7	R:R:L312	R:R:L44	20.6481	2.77	No	No	0	4	7
8	R:R:L312	R:R:V47	15.607	7.45	No	No	0	4	7
9	L:L:?1	R:R:K116	26.1934	12.17	Yes	Yes	1	0	6
10	R:R:K116	R:R:Q119	35.8333	5.42	Yes	Yes	1	6	7
11	R:R:P95	R:R:Q119	20.7202	3.16	Yes	Yes	1	5	7
12	R:R:L94	R:R:P95	18.858	3.28	No	Yes	0	8	5
13	R:R:F48	R:R:L94	16.2243	8.53	No	No	0	6	8
14	L:L:?1	R:R:F287	61.286	3.15	Yes	Yes	1	0	6
15	R:R:F287	R:R:W284	50.2881	6.01	Yes	Yes	1	6	8
16	R:R:N317	R:R:W284	74.5679	5.65	Yes	Yes	1	9	8
17	R:R:N317	R:R:N321	77.5823	6.81	Yes	Yes	0	9	9
18	R:R:D85	R:R:N321	32.8909	5.39	Yes	Yes	0	9	9
19	R:R:D85	R:R:N55	15.1955	12.12	Yes	Yes	3	9	9
20	R:R:C283	R:R:N317	20.5658	3.15	No	Yes	0	8	9
21	R:R:L81	R:R:N321	67.3354	5.49	No	Yes	0	9	9
22	R:R:L81	R:R:M129	66.4403	5.65	No	No	0	9	8
23	R:R:M129	R:R:W164	64.8148	9.31	No	Yes	0	8	9
24	R:R:H80	R:R:W164	100	5.29	Yes	Yes	0	9	9
25	R:R:H80	R:R:V160	93.7654	13.84	Yes	No	0	9	7
26	R:R:F77	R:R:V160	86.893	5.24	Yes	No	2	8	7
27	R:R:D136	R:R:F77	79.9794	14.33	Yes	Yes	0	9	8
28	R:R:D136	R:R:R137	69.7222	8.34	Yes	Yes	0	9	9
29	R:R:I74	R:R:R137	67.0885	3.76	No	Yes	0	8	9
30	R:R:I74	R:R:I78	65.5967	2.94	No	No	0	8	8
31	R:R:I78	R:R:Y325	63.9095	20.55	No	Yes	0	8	9
32	R:R:S329	R:R:Y325	28.2202	13.99	No	Yes	0	8	9
33	R:R:L62	R:R:Y325	28.9506	3.52	No	Yes	0	7	9
34	R:R:H75	R:R:L62	26.9033	9	No	No	0	9	7
35	R:R:S329	R:R:S331	19.6605	3.26	No	Yes	0	8	7
36	R:R:R65	R:R:S331	13.2099	7.91	Yes	Yes	4	5	7
37	R:R:H75	R:R:W71	22.6235	5.29	No	No	0	9	7
38	R:R:G153	R:R:W71	18.2613	5.63	No	No	0	4	7
39	R:R:F48	R:R:L90	10.8951	2.44	No	No	0	6	5
40	R:R:Q119	R:R:V115	10.5453	4.3	Yes	No	1	7	5
41	R:R:D191	R:R:F105	28.0556	4.78	No	Yes	0	4	8
42	R:R:D191	R:R:W193	20.6481	2.23	No	No	0	4	4
43	R:R:R181	R:R:W193	18.1379	2	No	No	0	1	4
44	R:R:C195	R:R:R181	15.607	5.57	No	No	0	2	1
45	R:R:A179	R:R:C195	13.0556	1.81	No	No	0	4	2
46	R:R:A179	R:R:R113	10.4835	2.77	No	No	0	4	7
47	R:R:K116	R:R:Q174	22.6955	6.78	Yes	No	0	6	5
48	R:R:M120	R:R:Q174	30.0926	9.52	Yes	No	0	5	5
49	R:R:M120	R:R:S171	58.642	4.6	Yes	No	0	5	7
50	R:R:S171	R:R:V121	42.6852	3.23	No	Yes	5	7	5
51	L:L:?1	R:R:I209	23.7551	4.93	Yes	Yes	1	0	5
52	R:R:I209	R:R:Y124	24.2901	4.84	Yes	Yes	1	5	7
53	R:R:M120	R:R:Y124	33.1379	3.59	Yes	Yes	0	5	7
54	R:R:S171	R:R:Y117	14.3107	7.63	No	Yes	5	7	5
55	R:R:S167	R:R:V121	45.2572	4.85	No	Yes	0	8	5
56	R:R:V213	R:R:Y124	12.7675	8.83	No	Yes	1	5	7
57	R:R:F287	R:R:F288	14.8251	11.79	Yes	Yes	1	6	7
58	R:R:Y124	R:R:Y128	44.4444	4.96	Yes	Yes	1	7	6
59	R:R:A125	R:R:S167	44.1461	3.42	No	No	0	7	8
60	R:R:P217	R:R:Y128	14.0123	8.34	No	Yes	0	9	6
61	R:R:S127	R:R:Y280	15.0823	6.36	No	Yes	0	8	9
62	R:R:L131	R:R:Y128	50.5658	4.69	No	Yes	0	7	6
63	R:R:I221	R:R:L131	48.4671	5.71	No	No	0	8	7
64	R:R:I221	R:R:T134	44.2078	9.12	No	No	0	8	8
65	R:R:D136	R:R:Y148	11.0082	2.3	Yes	No	0	9	6
66	R:R:C224	R:R:T134	35.4424	1.69	No	No	0	5	8
67	R:R:C224	R:R:H138	33.1996	2.95	No	Yes	0	5	8
68	R:R:H138	R:R:I228	12.0885	3.98	Yes	No	0	8	8
69	R:R:G153	R:R:S152	16.0494	1.86	No	No	0	4	7
70	R:R:S152	R:R:W156	11.5638	8.65	No	No	0	7	7
71	R:R:A210	R:R:F288	27.644	1.39	No	Yes	0	5	7
72	R:R:A210	R:R:L292	25.4527	4.73	No	No	0	5	5
73	R:R:L292	R:R:T207	23.2407	1.47	No	No	0	5	5
74	R:R:T207	R:R:W296	21.0082	3.64	No	No	0	5	4
75	R:R:F214	R:R:F288	20.8333	13.93	Yes	Yes	0	8	7
76	R:R:M272	R:R:Y325	11.2654	4.79	No	Yes	0	8	9
77	R:R:I276	R:R:I324	10.0926	5.89	No	No	0	8	8
78	R:R:A300	R:R:W296	11.8724	1.3	No	No	0	1	4
79	R:R:F288	R:R:V213	12.356	6.55	Yes	No	1	7	5
80	R:R:A125	R:R:W164	43.1584	5.19	No	Yes	0	7	9
81	R:R:P217	R:R:S127	13.7243	3.56	No	No	0	9	8
82	R:R:F288	R:R:W284	32.6029	4.01	Yes	Yes	1	7	8
83	R:R:N317	R:R:Y280	11.8107	5.81	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F105	19.97	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:K116	12.17	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F178	6.31	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:R202	6.29	1	Yes	No	0	4	0	1
L:L:?1	R:R:Y205	4.05	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:V206	9	1	Yes	No	0	5	0	1
L:L:?1	R:R:I209	4.93	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F287	3.15	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Q291	19.53	1	Yes	No	0	6	0	1
L:L:?1	R:R:F307	9.46	1	Yes	No	0	5	0	1
R:R:F105	R:R:T102	10.38	0	Yes	No	8	5	1	2
R:R:D191	R:R:F105	4.78	0	No	Yes	4	8	2	1
R:R:C192	R:R:F105	4.19	0	No	Yes	9	8	2	1
R:R:K116	R:R:Q119	5.42	1	Yes	Yes	6	7	1	2
R:R:K116	R:R:Q174	6.78	1	Yes	No	6	5	1	2
R:R:F178	R:R:K116	12.41	1	Yes	Yes	6	6	1	1
R:R:I209	R:R:Y124	4.84	1	Yes	Yes	5	7	1	2
R:R:P173	R:R:Y205	5.56	0	No	Yes	8	7	2	1
R:R:Q174	R:R:Y205	5.64	0	No	Yes	5	7	2	1
R:R:F178	R:R:I177	3.77	1	Yes	No	6	5	1	2
R:R:I177	R:R:Y205	3.63	0	No	Yes	5	7	2	1
R:R:A194	R:R:F178	5.55	0	No	Yes	5	6	2	1
R:R:F196	R:R:R202	7.48	0	No	No	5	4	2	1
R:R:W208	R:R:Y205	4.82	1	No	Yes	3	7	2	1
R:R:I209	R:R:Y205	8.46	1	Yes	Yes	5	7	1	1
R:R:A295	R:R:V206	5.09	0	No	No	5	5	2	1
R:R:I209	R:R:W208	5.87	1	Yes	No	5	3	1	2
R:R:F287	R:R:W284	6.01	1	Yes	Yes	6	8	1	2
R:R:F288	R:R:W284	4.01	1	Yes	Yes	7	8	2	2
R:R:F287	R:R:F288	11.79	1	Yes	Yes	6	7	1	2
R:R:F287	R:R:Q291	9.37	1	Yes	No	6	6	1	1
R:R:Q291	R:R:V290	5.73	1	No	No	6	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9U80_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	240
Number of Links	259
Number of Hubs	34
Number of Links mediated by Hubs	125
Number of Communities	5
Number of Nodes involved in Communities	34
Number of Links involved in Communities	45

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	27551
Length Of Smallest Path	3
Average Path Length	13.1209
Length of Longest Path	35
Minimum Path Strength	1.51
Average Path Strength	6.36685
Maximum Path Strength	17.27
Minimum Path Correlation	0.7
Average Path Correlation	0.915229
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	49.7958
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.8293
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• regulation of body fluid levels • hemostasis • biological regulation • regulation of biological quality • regulation of tube diameter • multicellular organismal process • regulation of biological process • system process • regulation of tube size • regulation of system process • positive regulation of biological process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • renal system process • transport • homeostatic process • fluid transport • establishment of localization • water transport • renal water transport • localization • multicellular organismal-level homeostasis • chemical homeostasis • renal absorption • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water absorption • renal water homeostasis • regulation of biosynthetic process • regulation of cellular process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • cellular process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • cellular response to stimulus • response to stimulus • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • response to peptide • response to cytokine • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of systemic arterial blood pressure • endocrine process • regulation of systemic arterial blood pressure by vasopressin • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of cell communication • regulation of signaling • positive regulation of signal transduction • positive regulation of intracellular signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • regulation of urine volume • renal water retention • negative regulation of urine volume • developmental process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • telencephalon development • system development • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • positive regulation of systemic arterial blood pressure • positive regulation of blood pressure • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular organelle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • vesicle • endocytic vesicle
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular organelle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • intracellular membrane-bounded organelle • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle • cytoplasm • organelle membrane • cell periphery • plasma membrane • Golgi apparatus • endomembrane system • endosome • perinuclear region of cytoplasm • endoplasmic reticulum
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30518
Sequence	>9U80_nogp_Chain_R L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G H W A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D R F R G P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R P M L A Y R H G S G A H W N R P V L V A W A F S L L L S L P Q L F I F A Q R D C W A C F W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D A P L E G A P F V L L M L L A S L N S C T N P W I Y A S F S S S V S S E L R S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	doi.org/10.1126/science.1215904
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	doi.org/10.1126/science.1215904
	7KH0	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	chim(NtGi1-Gs)/β1/γ2	2.8	2021-05-26	doi.org/10.1038/s41422-021-00483-z
	7KH0 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		2.8	2021-05-26	doi.org/10.1038/s41422-021-00483-z
	7BB6	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	Gs/β1/γ2	4.2	2021-06-02	doi.org/10.1126/sciadv.abg5628
	7BB6 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		4.2	2021-06-02	doi.org/10.1126/sciadv.abg5628
	7BB7	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	Gs/β1/γ2	4.4	2021-06-02	doi.org/10.1126/sciadv.abg5628
	7BB7 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		4.4	2021-06-02	doi.org/10.1126/sciadv.abg5628
	7DW9	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	chim(NtGi1-Gs)/β1/γ2	2.6	2021-07-21	doi.org/10.1038/s41422-021-00480-2
	7DW9 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		2.6	2021-07-21	doi.org/10.1038/s41422-021-00480-2
	7R0C	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	Arrestin2	4.73	2022-09-14	doi.org/10.1126/sciadv.abo7761
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9HAP	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	Tolvaptan	-	-	2.5	2025-06-04	doi.org/10.1038/s41467-025-59114-5
	9HB3	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	Mambaquaretin-1	-	-	2.5	2025-06-04	doi.org/10.1038/s41467-025-59114-5
	9V2N	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Macimorelin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.63	2025-07-02	doi.org/10.1038/s41401-025-01606-7
	9V2N (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Macimorelin	-		2.63	2025-07-02	doi.org/10.1038/s41401-025-01606-7
	9U80	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	Conivaptan	-	-	2.94	2025-12-10	10.1038/s41467-025-64735-x
	9U80 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	Conivaptan	-		2.94	2025-12-10	10.1038/s41467-025-64735-x
	9U81	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	Tolvaptan	-	-	3.08	2025-12-10	10.1038/s41467-025-64735-x
	9U81 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	Tolvaptan	-		3.08	2025-12-10	10.1038/s41467-025-64735-x

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9U80_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.