psnGPCR

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Orange: nodes, hubs and links specific of angiotensin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of angiotensin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	angiotensin_off Int. Strength	angiotensin_on Int. Strength	angiotensin_off Hub1?	angiotensin_on Hub1?	angiotensin_off Hub2?	angiotensin_on Hub2?	ConSurf1	ConSurf2
1	1x39	Lig	angiotensin_off	9.995	0	Yes	Yes	Yes	Yes	7	0
2	4x65	Lig	angiotensin_off	24.47	0	No	No	Yes	Yes	5	0
3	7x42	Lig	angiotensin_off	3.76	0	Yes	No	Yes	Yes	7	0
4	E3	NT	angiotensin_off	3.675	0	Yes	No	Yes	Yes	1	4
5	7x27	NT	angiotensin_off	4.505	0	No	No	Yes	Yes	3	4
6	1x32	NT	angiotensin_off	5.34	0	No	No	Yes	Yes	4	4
7	1x30	7x32	angiotensin_off	4.37	0	No	No	No	No	6	1
8	1x31	7x32	angiotensin_off	3.8	0	No	No	No	No	3	1
9	1x34	7x36	angiotensin_off	5.83	0	No	No	Yes	No	4	6
10	1x35	2x64	angiotensin_off	8.36	0	Yes	Yes	No	No	6	5
11	1x42	7x43	angiotensin_off	8.165	0	No	No	No	No	7	5
12	1x42	7x47	angiotensin_off	5.725	0	No	No	No	No	7	8
13	1x47	2x54	angiotensin_off	4.28	0	Yes	No	No	No	6	6
14	1x53	7x53	angiotensin_off	11.985	0	No	Yes	No	Yes	9	9
15	1x54	2x44	angiotensin_off	3.725	0	No	No	Yes	No	7	5
16	1x57	I1x50	angiotensin_off	4.28	0	No	No	Yes	No	7	7
17	1x57	2x40	angiotensin_off	3.87	0	No	No	Yes	No	7	8
18	1x58	I1x50	angiotensin_off	4.1	0	No	No	Yes	No	4	7
19	1x58	2x44	angiotensin_off	6.45	0	No	No	Yes	No	4	5
20	2x38	3x49	angiotensin_off	8.03	0	No	No	No	No	7	8
21	2x42	4x46	angiotensin_off	4.89	0	Yes	Yes	No	No	7	7
22	2x43	7x53	angiotensin_off	7.62	0	No	No	No	Yes	8	9
23	2x53	2x57	angiotensin_off	6.7	0	Yes	No	Yes	Yes	6	8
24	2x53	3x32	angiotensin_off	6.55	0	Yes	No	No	No	6	6
25	2x53	7x42	angiotensin_off	14.44	0	Yes	No	Yes	No	6	7
26	2x53	7x46	angiotensin_off	13.895	0	Yes	No	Yes	No	6	9
27	2x60	E1x50	angiotensin_off	10.31	0	Yes	Yes	Yes	Yes	7	9
28	2x60	3x29	angiotensin_off	4.94	0	Yes	Yes	No	No	7	5
29	7x35	E1	angiotensin_off	3.475	0	No	No	Yes	Yes	5	4
30	3x26	E2	angiotensin_off	6.295	0	No	No	Yes	Yes	6	4
31	3x35	7x42	angiotensin_off	6.975	0	No	No	Yes	No	8	7
32	3x35	7x46	angiotensin_off	12.26	0	No	No	Yes	No	8	9
33	3x39	6x44	angiotensin_off	5.285	0	No	No	Yes	No	9	9
34	3x41	4x49	angiotensin_off	5.65	0	No	No	No	No	5	7
35	3x43	6x41	angiotensin_off	5.215	0	No	No	No	No	8	8
36	3x43	6x44	angiotensin_off	6.7	0	No	No	Yes	No	8	9
37	3x44	5x54	angiotensin_off	7.6	0	No	No	Yes	No	7	8
38	3x46	6x37	angiotensin_off	9.99	0	No	No	Yes	No	9	7
39	3x49	3x50	angiotensin_off	6.55	0	No	No	Yes	No	8	9
40	3x50	3x53	angiotensin_off	4.15	0	Yes	No	No	No	9	8
41	3x50	6x30	angiotensin_off	4.22	0	Yes	No	Yes	No	9	6
42	3x50	6x37	angiotensin_off	3.76	0	Yes	No	Yes	No	9	7
43	3x51	5x57	angiotensin_off	4.455	0	Yes	Yes	No	No	8	7
44	3x54	6x30	angiotensin_off	9.205	0	No	No	Yes	No	8	6
45	I2x54	I2x56	angiotensin_off	5.33	0	No	No	No	No	4	4
46	I2x54	I2x57	angiotensin_off	4.8	0	No	No	No	Yes	4	6
47	4x51	4x55	angiotensin_off	4.15	0	No	No	No	No	4	4
48	4x63	4x64	angiotensin_off	9.28	0	No	No	No	No	4	4
49	4x64	E2x52	angiotensin_off	14.71	0	No	No	No	Yes	4	4
50	5x44	5x47	angiotensin_off	4.23	0	No	No	Yes	Yes	4	8
51	5x45	5x48	angiotensin_off	3.57	0	No	No	No	No	5	4
52	5x45	5x49	angiotensin_off	9.42	0	No	No	Yes	No	5	6
53	5x48	5x49	angiotensin_off	6.7	0	No	No	Yes	No	4	6
54	5x54	5x58	angiotensin_off	3.63	0	Yes	No	Yes	Yes	8	9
55	5x54	6x45	angiotensin_off	4.395	0	Yes	No	Yes	Yes	8	5
56	5x61	6x34	angiotensin_off	8.795	0	No	No	No	Yes	8	6
57	5x65	6x30	angiotensin_off	6.865	0	No	No	Yes	No	8	6
58	6x30	6x31	angiotensin_off	4.715	0	Yes	No	No	No	6	4
59	6x32	6x35	angiotensin_off	3.455	0	No	No	No	No	7	5
60	6x35	7x55	angiotensin_off	9.305	0	No	No	No	No	5	6
61	6x36	7x53	angiotensin_off	4.23	0	No	No	No	Yes	8	9
62	6x36	7x55	angiotensin_off	3.77	0	No	No	No	No	8	6
63	6x40	7x49	angiotensin_off	8.5	0	No	No	No	No	8	9
64	6x40	7x52	angiotensin_off	3.77	0	No	No	Yes	No	8	8
65	6x44	6x45	angiotensin_off	5.895	0	Yes	No	Yes	Yes	9	5
66	6x44	7x45	angiotensin_off	7.855	0	Yes	No	No	No	9	9
67	6x48	7x41	angiotensin_off	9.725	0	Yes	Yes	No	No	8	8
68	6x48	7x42	angiotensin_off	7.235	0	Yes	Yes	Yes	No	8	7
69	6x58	6x62	angiotensin_off	9.14	0	No	No	No	No	4	3
70	6x58	7x34	angiotensin_off	5.545	0	No	No	No	No	4	4
71	6x63	E3	angiotensin_off	4.995	0	Yes	No	Yes	No	1	1
72	7x23	7x26	angiotensin_off	11.895	0	No	No	No	No	4	1
73	7x25	7x29	angiotensin_off	4.385	0	No	No	No	No	2	1
74	7x43	7x47	angiotensin_off	3.49	0	No	No	No	No	5	8
75	7x45	7x46	angiotensin_off	8.175	0	No	No	Yes	No	9	9
76	7x45	7x49	angiotensin_off	11.58	0	No	No	No	No	9	9
77	7x48	7x52	angiotensin_off	4.26	0	No	No	Yes	No	6	8
78	8x53	8x57	angiotensin_off	4.69	0	No	Yes	No	No	5	4
79	5x47	5x51	angiotensin_off	6.965	0	Yes	Yes	No	No	8	6
80	1x50	2x51	angiotensin_off	3.43	0	No	No	No	No	9	7
81	3x34	4x57	angiotensin_off	3.3	0	Yes	Yes	No	No	5	7
82	2x52	4x50	angiotensin_off	3.265	0	No	No	Yes	Yes	7	9
83	6x61	7x27	angiotensin_off	3.25	0	No	No	No	No	2	3
84	7x28	NT	angiotensin_off	3.225	0	No	No	Yes	Yes	4	4
85	6x33	6x37	angiotensin_off	2.94	0	No	No	Yes	No	7	7
86	4x59	4x63	angiotensin_off	2.855	0	No	No	No	No	4	4
87	5x37	6x63	angiotensin_off	2.855	0	No	No	Yes	No	2	1
88	2x42	4x42	angiotensin_off	2.77	0	Yes	Yes	No	No	7	7
89	2x46	3x42	angiotensin_off	2.77	0	No	Yes	No	No	9	7
90	3x34	3x38	angiotensin_off	2.77	0	Yes	Yes	No	No	5	7
91	6x54	7x30	angiotensin_off	2.62	0	No	No	No	No	5	4
92	5x40	5x43	angiotensin_off	2.615	0	No	No	No	Yes	5	5
93	6x46	6x49	angiotensin_off	2.51	0	No	No	No	Yes	6	5
94	5x46	5x49	angiotensin_off	2.435	0	No	No	Yes	No	4	6
95	1x60	8x49	angiotensin_off	2.39	0	Yes	Yes	No	No	4	6
96	2x38	4x38	angiotensin_off	2.38	0	No	No	No	No	7	7
97	6x47	7x40	angiotensin_off	2.325	0	No	No	No	No	8	8
98	2x39	3x49	angiotensin_off	2.315	0	No	No	No	No	7	8
99	2x41	I1x50	angiotensin_off	2.235	0	Yes	Yes	Yes	No	6	7
100	4x38	I2x55	angiotensin_off	2.21	0	No	No	No	No	7	4
101	5x35	E2	angiotensin_off	2.165	0	No	No	Yes	Yes	1	4
102	4x48	4x52	angiotensin_off	2.14	0	No	No	No	No	3	4
103	I1x51	I2x55	angiotensin_off	2.115	0	No	No	No	No	7	4
104	1x60	8x50	angiotensin_off	2.065	0	Yes	Yes	No	Yes	4	8
105	5x41	5x44	angiotensin_off	2.06	0	No	No	No	No	4	4
106	4x61	Lig	angiotensin_off	2.02	0	No	No	Yes	Yes	4	0
107	1x43	1x44	angiotensin_off	1.965	0	Yes	No	No	No	6	5
108	2x49	3x38	angiotensin_off	1.79	0	No	No	No	No	8	7
109	3x30	4x61	angiotensin_off	1.79	0	No	No	No	No	5	4
110	5x37	5x38	angiotensin_off	1.765	0	No	No	No	No	2	4
111	1x45	7x47	angiotensin_off	1.71	0	No	No	No	No	5	8
112	2x48	4x50	angiotensin_off	1.71	0	No	No	Yes	Yes	5	9
113	2x56	3x28	angiotensin_off	1.68	0	No	No	No	No	7	6
114	5x42	5x45	angiotensin_off	1.52	0	No	No	No	No	3	5
115	5x39	5x42	angiotensin_off	1.475	0	No	No	No	No	5	3
116	1x37	1x38	angiotensin_off	1.47	0	No	No	No	No	6	5
117	7x36	7x40	angiotensin_off	1.47	0	Yes	No	No	No	6	8
118	1x31	7x36	angiotensin_off	1.47	0	No	No	Yes	No	3	6
119	8x48	8x51	angiotensin_off	1.435	0	No	No	No	No	5	8
120	3x24	3x27	angiotensin_off	1.425	0	No	No	No	No	5	6
121	7x48	7x51	angiotensin_off	1.385	0	No	No	No	No	6	6
122	5x48	5x52	angiotensin_off	1.38	0	No	No	No	No	4	3
123	1x44	1x48	angiotensin_off	1.31	0	No	No	No	No	5	4
124	1x56	1x60	angiotensin_off	1.26	0	No	No	Yes	Yes	7	4
125	6x63	6x64	angiotensin_off	0.855	0	Yes	No	No	No	1	2
126	E2	E2x51	angiotensin_off	0.85	0	Yes	Yes	No	No	4	5
127	3x54	5x64	angiotensin_off	0.81	0	No	No	No	No	8	5
128	5x61	5x64	angiotensin_off	0.81	0	No	No	No	No	8	5
129	1x55	1x56	angiotensin_off	0.77	0	No	No	No	No	3	7
130	8x47	8x50	angiotensin_off	0.755	0	No	No	No	Yes	8	8
131	7x54	7x55	angiotensin_off	0.755	0	No	No	No	No	7	6
132	5x59	5x63	angiotensin_off	0.75	0	No	No	No	No	3	3
133	I2x51	I2x52	angiotensin_off	0.72	0	No	No	No	No	6	4
134	1x47	2x55	angiotensin_off	0.715	0	Yes	No	No	No	6	4
135	4x48	4x51	angiotensin_off	0.715	0	No	No	No	No	3	4
136	1x52	1x55	angiotensin_off	0.715	0	No	No	No	No	6	3
137	3x52	I2x51	angiotensin_off	0.705	0	No	No	No	No	5	6
138	8x57	8x58	angiotensin_off	0.69	0	No	No	No	No	4	6
139	I2x52	I2x54	angiotensin_off	0.62	0	No	No	No	No	4	4
140	8x49	8x52	angiotensin_off	0.62	0	No	No	No	No	6	5
141	2x60	Lig	Shared	27.54	16.21	Yes	Yes	Yes	Yes	7	0
142	3x32	Lig	Shared	15.23	3.93	No	No	Yes	Yes	6	0
143	3x33	Lig	Shared	13.42	5.28	No	No	Yes	Yes	4	0
144	E2x52	Lig	Shared	5.88	6.19	No	Yes	Yes	Yes	4	0
145	7x38	Lig	Shared	9.15	6.41	No	No	Yes	Yes	6	0
146	NT	NT	Shared	18.76	17	Yes	Yes	Yes	Yes	4	4
147	E2	NT	Shared	9.17	74.91	Yes	Yes	Yes	Yes	4	4
148	7x24	NT	Shared	7.28	7.28	No	No	Yes	Yes	7	4
149	7x31	NT	Shared	6.31	6.31	No	No	Yes	Yes	4	4
150	E1	NT	Shared	6.175	7.2	Yes	Yes	Yes	Yes	4	4
151	1x28	1x30	Shared	9.255	10.89	No	Yes	No	No	4	6
152	1x28	7x28	Shared	10.715	7.56	No	Yes	No	No	4	4
153	1x28	7x32	Shared	7.53	5.48	No	Yes	No	No	4	1
154	1x30	1x31	Shared	5.44	7.25	No	No	No	No	6	3
155	1x32	2x67	Shared	15.74	16.32	No	No	No	No	4	3
156	1x32	E1	Shared	6.705	4.13	No	No	Yes	Yes	4	4
157	1x35	1x39	Shared	7.25	6.04	Yes	Yes	Yes	Yes	6	7
158	1x36	2x65	Shared	3.74	3.74	No	No	No	No	5	3
159	1x39	2x57	Shared	7.615	8.21	Yes	Yes	Yes	Yes	7	8
160	1x39	7x39	Shared	5.375	4.03	Yes	Yes	No	No	7	5
161	1x43	1x47	Shared	8.79	5.02	Yes	No	Yes	No	6	6
162	1x43	2x58	Shared	11.555	14.45	Yes	No	No	No	6	9
163	1x49	7x50	Shared	4.06	2.03	No	No	No	No	7	9
164	1x50	2x50	Shared	9.425	6.73	No	No	Yes	Yes	9	9
165	1x50	7x50	Shared	11.4	11.4	No	No	No	No	9	9
166	1x57	2x44	Shared	12.135	4.28	No	No	Yes	No	7	5
167	1x60	8x53	Shared	4.47	10.92	Yes	Yes	No	Yes	4	5
168	2x40	I1x48	Shared	5.365	7.67	Yes	No	No	No	8	5
169	2x40	I1x50	Shared	3.755	3	Yes	No	Yes	No	8	7
170	2x44	I1x50	Shared	4.845	5.54	Yes	No	Yes	No	5	7
171	2x42	3x45	Shared	12.57	4.19	Yes	Yes	No	No	7	7
172	2x42	3x46	Shared	4.875	3.65	Yes	Yes	No	No	7	9
173	2x42	4x45	Shared	4.54	5.19	Yes	Yes	No	No	7	5
174	2x43	3x46	Shared	4.845	2.77	No	No	No	No	8	9
175	2x45	4x46	Shared	11.02	7.87	No	No	No	No	9	7
176	2x45	4x50	Shared	4.52	6.78	No	No	Yes	Yes	9	9
177	2x46	2x50	Shared	4.75	4.07	No	Yes	Yes	Yes	9	9
178	2x50	7x46	Shared	12.115	4.63	Yes	Yes	Yes	No	9	9
179	2x50	7x49	Shared	6.06	6.73	Yes	Yes	No	No	9	9
180	2x53	3x35	Shared	13.29	1.56	Yes	No	No	No	6	8
181	2x56	3x31	Shared	7.995	6.4	No	No	No	No	7	5
182	2x59	E1x52	Shared	11.57	4.87	No	No	Yes	Yes	6	6
183	2x60	2x63	Shared	4.82	3.86	Yes	Yes	No	Yes	7	5
184	2x60	3x28	Shared	3.89	3.89	Yes	Yes	No	No	7	6
185	2x63	E1	Shared	6.45	10.92	No	Yes	Yes	Yes	5	4
186	2x63	E1x50	Shared	8.2	10.61	No	Yes	Yes	Yes	5	9
187	2x64	E1	Shared	5.62	7.49	No	No	Yes	Yes	5	4
188	2x66	E1x51	Shared	4.19	3.35	No	No	No	No	5	3
189	E1x49	E2	Shared	14.415	5.01	No	No	Yes	Yes	5	4
190	E1x50	E1x52	Shared	12.025	17.04	Yes	Yes	Yes	Yes	9	6
191	3x25	E1x50	Shared	4.57	9.14	No	No	Yes	Yes	9	9
192	E1x50	E2x50	Shared	11.1	15.67	Yes	Yes	No	No	9	9
193	E1x51	E1x52	Shared	13	7.22	No	No	Yes	Yes	3	6
194	3x24	E1x52	Shared	4.26	6.09	No	No	Yes	Yes	5	6
195	3x22	3x26	Shared	4.2	8.39	No	No	No	No	3	6
196	3x22	E2	Shared	14.71	12.72	No	No	Yes	Yes	3	4
197	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
198	3x29	4x65	Shared	13.835	15.81	No	No	No	No	5	5
199	3x32	7x42	Shared	5.05	3.79	No	No	Yes	No	6	7
200	3x34	4x50	Shared	10.02	7.02	Yes	Yes	Yes	Yes	5	9
201	3x34	4x53	Shared	6.24	2.77	Yes	Yes	No	No	5	8
202	3x36	6x48	Shared	13.67	3.42	No	No	Yes	Yes	7	8
203	3x37	3x41	Shared	3.61	6.19	No	Yes	No	No	7	5
204	3x37	4x56	Shared	9.34	8.01	No	Yes	No	No	7	5
205	3x37	5x43	Shared	3.585	4.78	No	Yes	No	Yes	7	5
206	3x40	5x50	Shared	3.53	3.53	No	No	Yes	Yes	8	8
207	3x42	4x49	Shared	4.28	2.85	No	No	No	No	7	7
208	3x47	5x54	Shared	10.065	4.64	No	No	Yes	No	9	8
209	3x47	5x58	Shared	11.45	5.09	No	No	Yes	Yes	9	9
210	3x51	3x52	Shared	3.52	3.52	Yes	Yes	No	No	8	5
211	3x51	3x55	Shared	11.36	11.36	Yes	Yes	No	No	8	7
212	3x51	3x56	Shared	7.08	8.71	Yes	Yes	No	No	8	6
213	3x51	5x60	Shared	5.275	8.21	Yes	Yes	No	No	8	3
214	3x54	5x61	Shared	11.775	4.42	No	No	No	No	8	8
215	3x55	3x56	Shared	7.61	11.07	No	No	No	No	7	6
216	E2	E2	Shared	40.29	65.49	Yes	Yes	Yes	Yes	4	4
217	E2	E2x52	Shared	12.895	4.13	Yes	Yes	No	Yes	4	4
218	6x62	E2	Shared	9.585	18.18	No	No	Yes	Yes	3	4
219	5x47	6x45	Shared	4.285	6.43	Yes	Yes	Yes	Yes	8	5
220	5x47	6x52	Shared	13.47	10.54	Yes	Yes	No	No	8	8
221	5x51	6x45	Shared	23.045	9.65	No	No	Yes	Yes	6	5
222	5x58	6x37	Shared	4.235	3.63	Yes	Yes	Yes	No	9	7
223	5x58	6x41	Shared	10.095	5.05	Yes	Yes	No	No	9	8
224	5x62	5x66	Shared	6.38	3.48	No	Yes	No	No	5	5
225	5x62	6x34	Shared	4.01	10.02	No	Yes	No	Yes	5	6
226	5x62	6x38	Shared	5.235	4.65	No	Yes	No	No	5	4
227	6x31	6x32	Shared	8.65	10.65	No	No	No	No	4	7
228	6x39	7x52	Shared	8.32	2.77	No	No	Yes	No	5	8
229	6x43	6x47	Shared	7.265	3.96	No	Yes	No	No	6	8
230	6x43	7x48	Shared	9.135	7.31	No	Yes	No	No	6	6
231	6x43	7x52	Shared	4.29	11.79	No	Yes	Yes	No	6	8
232	6x44	6x48	Shared	8.015	5.01	Yes	No	Yes	Yes	9	8
233	6x51	6x55	Shared	5.475	6.85	No	Yes	No	No	6	6
234	6x51	7x37	Shared	8.895	8.21	No	Yes	No	No	6	7
235	6x51	7x38	Shared	9.28	3.98	No	Yes	No	No	6	6
236	6x54	7x33	Shared	7.625	8.32	No	No	No	No	5	5
237	6x56	6x60	Shared	6.09	6.09	No	No	No	No	5	3
238	6x57	7x30	Shared	5.215	2.98	No	No	No	No	5	4
239	6x60	E3	Shared	7.85	9.99	No	No	Yes	No	3	1
240	6x61	7x30	Shared	4.61	4.61	No	No	No	No	2	4
241	7x26	E3	Shared	5.89	4.42	No	No	Yes	No	1	1
242	7x23	7x25	Shared	4.165	4.76	No	No	No	No	4	2
243	5x44	6x52	Shared	5.94	3.96	No	No	No	No	4	8
244	1x46	2x54	Shared	3.42	1.71	No	Yes	No	No	8	6
245	1x35	1x36	Shared	3.39	3.39	Yes	Yes	No	No	6	5
246	6x49	6x50	Shared	3.39	5.08	No	Yes	No	No	5	9
247	1x39	2x61	Shared	3.335	2.67	Yes	Yes	No	No	7	7
248	2x62	E1x52	Shared	3.275	2.62	No	No	Yes	Yes	4	6
249	3x47	5x57	Shared	3.26	4.89	No	No	No	No	9	7
250	3x30	4x62	Shared	3.25	4.87	No	No	No	No	5	5
251	3x48	5x53	Shared	2.94	2.94	No	No	No	No	6	7
252	6x49	6x53	Shared	2.94	4.42	No	Yes	No	No	5	6
253	5x49	5x50	Shared	2.885	1.44	Yes	No	Yes	Yes	6	8
254	1x42	2x57	Shared	2.85	2.85	No	No	Yes	Yes	7	8
255	6x38	6x42	Shared	2.825	2.83	No	No	No	No	4	5
256	3x21	E1x50	Shared	2.81	2.81	No	No	Yes	Yes	8	9
257	3x44	5x50	Shared	2.625	3.5	No	No	Yes	Yes	7	8
258	6x50	7x37	Shared	2.625	3.5	No	No	No	No	9	7
259	1x53	2x47	Shared	2.545	1.7	No	Yes	No	No	9	8
260	2x41	4x42	Shared	2.545	5.09	Yes	Yes	No	No	6	7
261	1x43	2x57	Shared	2.435	3.65	Yes	No	Yes	Yes	6	8
262	3x41	4x52	Shared	2.435	3.65	No	No	No	No	5	4
263	2x37	2x40	Shared	2.4	4.8	No	No	Yes	No	8	8
264	1x38	7x39	Shared	2.38	6.35	No	No	No	No	5	5
265	3x44	5x53	Shared	2.28	6.08	No	No	No	No	7	7
266	3x34	4x54	Shared	2.26	3.01	Yes	Yes	No	No	5	3
267	6x59	6x63	Shared	2.235	1.49	No	No	Yes	No	4	1
268	6x36	7x56	Shared	2.14	4.28	No	No	No	No	8	7
269	5x36	E2	Shared	2.085	13.08	No	No	Yes	Yes	3	4
270	5x461	5x50	Shared	2.03	4.06	No	No	Yes	Yes	5	8
271	5x51	5x55	Shared	1.825	6.09	No	No	No	No	6	5
272	4x59	4x60	Shared	1.64	3.28	No	No	No	No	4	6
273	4x38	4x41	Shared	1.585	3.17	No	No	No	No	7	4
274	1x41	1x45	Shared	1.54	1.54	No	No	No	No	5	5
275	4x44	4x48	Shared	1.54	3.07	No	No	No	No	3	3
276	2x41	4x39	Shared	1.52	1.52	Yes	Yes	No	No	6	1
277	2x41	4x43	Shared	1.52	4.55	Yes	Yes	No	No	6	3
278	5x55	5x59	Shared	1.475	2.95	No	No	No	No	5	3
279	1x35	7x36	Shared	1.47	2.94	Yes	Yes	Yes	No	6	6
280	1x55	1x59	Shared	1.255	3.77	No	No	No	No	3	4
281	1x58	1x59	Shared	1.03	7.22	No	No	No	No	4	4
282	1x47	1x51	Shared	0.775	1.55	Yes	No	No	No	6	3
283	3x56	I2x50	Shared	0.765	1.53	No	No	No	No	6	8
284	4x40	4x44	Shared	0.745	1.49	No	No	No	No	4	3
285	Lig	NT	angiotensin_on	0	16.75	Yes	Yes	Yes	Yes	0	4
286	1x28	1x31	angiotensin_on	0	5.3	No	Yes	No	No	4	3
287	1x35	7x35	angiotensin_on	0	5.08	Yes	Yes	No	No	6	5
288	1x39	7x38	angiotensin_on	0	6.04	Yes	Yes	No	No	7	6
289	1x52	7x55	angiotensin_on	0	3.65	No	No	No	No	6	6
290	1x52	8x54	angiotensin_on	0	6.09	No	No	No	No	6	7
291	1x53	1x57	angiotensin_on	0	3.07	No	Yes	No	No	9	7
292	1x53	7x50	angiotensin_on	0	3.53	No	Yes	No	No	9	9
293	1x56	8x50	angiotensin_on	0	3.93	No	No	No	Yes	7	8
294	1x56	8x53	angiotensin_on	0	3.79	No	No	No	Yes	7	5
295	1x59	1x60	angiotensin_on	0	3.09	No	No	Yes	Yes	4	4
296	1x60	8x56	angiotensin_on	0	7.89	Yes	Yes	No	No	4	3
297	1x60	8x57	angiotensin_on	0	8.21	Yes	Yes	No	No	4	4
298	1x60	8x60	angiotensin_on	0	3.97	Yes	Yes	No	No	4	0
299	I1x49	I1x51	angiotensin_on	0	5.75	No	No	No	No	5	7
300	2x42	3x49	angiotensin_on	0	9.55	Yes	Yes	No	No	7	8
301	2x45	3x42	angiotensin_on	0	4.12	No	No	No	No	9	7
302	2x46	3x43	angiotensin_on	0	5.54	No	Yes	No	No	9	8
303	2x46	7x49	angiotensin_on	0	4.12	No	Yes	No	No	9	9
304	2x46	7x53	angiotensin_on	0	3.52	No	Yes	No	Yes	9	9
305	2x50	3x39	angiotensin_on	0	5.89	Yes	Yes	No	No	9	9
306	2x52	3x35	angiotensin_on	0	6.3	No	No	No	No	7	8
307	2x56	2x59	angiotensin_on	0	4.42	No	No	No	No	7	6
308	2x56	2x60	angiotensin_on	0	4.85	No	No	Yes	Yes	7	7
309	2x57	7x42	angiotensin_on	0	8.21	Yes	Yes	Yes	No	8	7
310	2x63	Lig	angiotensin_on	0	4.84	No	Yes	Yes	Yes	5	0
311	2x67	E1x49	angiotensin_on	0	10.47	No	No	No	No	3	5
312	E1	Lig	angiotensin_on	0	10.64	Yes	Yes	Yes	Yes	4	0
313	3x33	4x57	angiotensin_on	0	6.52	No	No	No	No	4	7
314	3x33	4x61	angiotensin_on	0	3.42	No	No	No	No	4	4
315	3x34	3x35	angiotensin_on	0	4.83	Yes	Yes	No	No	5	8
316	3x36	7x42	angiotensin_on	0	7.03	No	No	Yes	No	7	7
317	3x36	Lig	angiotensin_on	0	4.87	No	No	Yes	Yes	7	0
318	3x37	5x42	angiotensin_on	0	4.99	No	Yes	No	No	7	3
319	3x37	Lig	angiotensin_on	0	4.13	No	Yes	Yes	Yes	7	0
320	3x38	4x50	angiotensin_on	0	6.48	No	No	Yes	Yes	7	9
321	3x40	6x48	angiotensin_on	0	4.9	No	No	Yes	Yes	8	8
322	3x43	7x53	angiotensin_on	0	5.86	No	No	No	Yes	8	9
323	3x45	4x49	angiotensin_on	0	3.27	No	No	No	No	7	7
324	3x49	I2x57	angiotensin_on	0	10.72	No	No	No	Yes	8	6
325	3x50	5x58	angiotensin_on	0	8.23	Yes	No	Yes	Yes	9	9
326	3x50	7x53	angiotensin_on	0	7.2	Yes	No	No	Yes	9	9
327	3x51	5x61	angiotensin_on	0	3.63	Yes	Yes	No	No	8	8
328	3x52	I2x57	angiotensin_on	0	3.64	No	No	No	Yes	5	6
329	3x53	I2x57	angiotensin_on	0	5.53	No	No	No	Yes	8	6
330	3x55	5x64	angiotensin_on	0	5.09	No	No	No	No	7	5
331	I2x53	I2x57	angiotensin_on	0	6.59	No	No	No	Yes	6	6
332	4x64	5x36	angiotensin_on	0	4.58	No	No	No	No	4	3
333	4x65	E2x52	angiotensin_on	0	17.1	No	No	No	Yes	5	4
334	E2	E2x50	angiotensin_on	0	5.12	Yes	Yes	No	No	4	9
335	E2	Lig	angiotensin_on	0	34.3	Yes	Yes	Yes	Yes	4	0
336	E2x51	Lig	angiotensin_on	0	4.95	No	No	Yes	Yes	5	0
337	5x39	E2x52	angiotensin_on	0	4.87	No	No	No	Yes	5	4
338	5x37	6x62	angiotensin_on	0	6.86	No	No	No	No	2	3
339	5x43	6x51	angiotensin_on	0	7.86	No	Yes	No	Yes	5	6
340	5x43	6x55	angiotensin_on	0	10.51	No	Yes	No	No	5	6
341	5x43	Lig	angiotensin_on	0	24.77	No	Yes	Yes	Yes	5	0
342	5x44	6x56	angiotensin_on	0	3.62	No	No	No	No	4	5
343	5x47	6x49	angiotensin_on	0	3.77	Yes	Yes	No	Yes	8	5
344	5x51	6x44	angiotensin_on	0	3.22	No	No	Yes	No	6	9
345	5x54	6x44	angiotensin_on	0	5.02	Yes	No	Yes	No	8	9
346	5x58	6x40	angiotensin_on	0	4.84	Yes	Yes	No	No	9	8
347	5x62	6x37	angiotensin_on	0	5.87	No	Yes	Yes	No	5	7
348	5x65	6x34	angiotensin_on	0	4.87	No	No	No	Yes	8	6
349	5x66	6x34	angiotensin_on	0	8.69	No	No	No	Yes	5	6
350	6x28	I3	angiotensin_on	0	5.56	No	No	No	Yes	0	0
351	6x30	I3	angiotensin_on	0	6.98	Yes	No	No	Yes	6	0
352	6x33	I3	angiotensin_on	0	4.84	No	No	No	Yes	7	0
353	I3	I3	angiotensin_on	0	4.06	No	Yes	No	Yes	0	0
354	6x29	I3	angiotensin_on	0	3.71	No	No	No	Yes	0	0
355	6x28	6x30	angiotensin_on	0	6.52	No	No	Yes	No	0	6
356	6x30	6x34	angiotensin_on	0	6.04	Yes	No	No	Yes	6	6
357	6x33	6x34	angiotensin_on	0	3.77	No	No	No	Yes	7	6
358	6x40	7x53	angiotensin_on	0	8.46	No	No	No	Yes	8	9
359	6x43	7x45	angiotensin_on	0	6.04	No	Yes	No	No	6	9
360	6x45	6x46	angiotensin_on	0	10.72	Yes	Yes	No	No	5	6
361	6x45	6x49	angiotensin_on	0	7.54	Yes	Yes	No	Yes	5	5
362	6x47	7x45	angiotensin_on	0	8.94	No	No	No	No	8	9
363	6x48	6x52	angiotensin_on	0	3.29	Yes	Yes	No	No	8	8
364	6x48	7x45	angiotensin_on	0	7.91	Yes	Yes	No	No	8	9
365	6x50	7x40	angiotensin_on	0	5.08	No	No	No	No	9	8
366	6x51	7x34	angiotensin_on	0	3.94	No	Yes	No	No	6	4
367	6x51	Lig	angiotensin_on	0	7.92	No	Yes	Yes	Yes	6	0
368	6x58	Lig	angiotensin_on	0	14.05	No	No	Yes	Yes	4	0
369	6x61	E3	angiotensin_on	0	5.89	No	No	Yes	No	2	1
370	6x61	Lig	angiotensin_on	0	5.01	No	No	Yes	Yes	2	0
371	7x24	7x27	angiotensin_on	0	3.61	No	No	No	No	7	3
372	7x26	7x29	angiotensin_on	0	4.42	No	No	No	No	1	1
373	7x28	7x32	angiotensin_on	0	4.34	No	No	No	No	4	1
374	7x31	Lig	angiotensin_on	0	22.07	No	No	Yes	Yes	4	0
375	7x34	Lig	angiotensin_on	0	13.98	No	No	Yes	Yes	4	0
376	7x35	Lig	angiotensin_on	0	7.63	No	No	Yes	Yes	5	0
377	7x40	7x43	angiotensin_on	0	5.02	No	No	No	No	8	5
378	7x49	7x53	angiotensin_on	0	3.49	No	No	No	Yes	9	9
379	7x55	8x50	angiotensin_on	0	5.36	No	No	No	Yes	6	8
380	8x49	8x53	angiotensin_on	0	9.55	No	No	No	Yes	6	5
381	8x50	8x53	angiotensin_on	0	4.13	No	Yes	No	Yes	8	5
382	8x52	8x53	angiotensin_on	0	11.32	No	No	No	Yes	5	5
383	8x52	8x56	angiotensin_on	0	8.18	No	No	No	No	5	3
384	8x53	8x56	angiotensin_on	0	4.51	No	Yes	No	No	5	3
385	Lig	Lig	angiotensin_on	0	29.98	Yes	Yes	Yes	Yes	0	0
386	7x54	8x50	angiotensin_on	0	3.01	No	No	No	Yes	7	8
387	5x42	5x46	angiotensin_on	0	2.95	No	No	No	No	3	4
388	1x31	1x35	angiotensin_on	0	2.94	No	No	Yes	Yes	3	6
389	4x62	4x63	angiotensin_on	0	2.94	No	No	No	No	5	4
390	6x36	6x40	angiotensin_on	0	2.94	No	No	No	No	8	8
391	1x34	1x35	angiotensin_on	0	2.92	No	No	Yes	Yes	4	6
392	1x47	2x51	angiotensin_on	0	2.85	Yes	No	No	No	6	7
393	3x54	5x65	angiotensin_on	0	2.85	No	No	No	No	8	8
394	5x61	5x65	angiotensin_on	0	2.85	No	No	No	No	8	8
395	2x44	2x48	angiotensin_on	0	2.77	Yes	No	No	No	5	5
396	3x41	4x53	angiotensin_on	0	2.77	No	No	No	No	5	8
397	6x31	6x35	angiotensin_on	0	2.77	No	No	No	No	4	5
398	7x51	7x56	angiotensin_on	0	2.77	No	No	No	No	6	7
399	1x53	7x55	angiotensin_on	0	2.62	No	Yes	No	No	9	6
400	2x38	2x42	angiotensin_on	0	2.62	No	No	Yes	Yes	7	7
401	2x38	I2x57	angiotensin_on	0	2.62	No	No	No	Yes	7	6
402	2x49	4x50	angiotensin_on	0	2.59	No	No	Yes	Yes	8	9
403	6x54	7x37	angiotensin_on	0	2.59	No	No	No	No	5	7
404	4x64	5x35	angiotensin_on	0	2.57	No	No	No	No	4	1
405	7x25	7x26	angiotensin_on	0	2.51	No	No	No	No	2	1
406	5x47	5x48	angiotensin_on	0	2.44	Yes	Yes	No	No	8	4
407	5x62	5x63	angiotensin_on	0	2.32	No	Yes	No	No	5	3
408	1x46	7x47	angiotensin_on	0	1.96	No	Yes	No	No	8	8
409	1x45	1x46	angiotensin_on	0	1.84	No	No	No	Yes	5	8
410	5x40	6x59	angiotensin_on	0	1.84	No	No	No	No	5	4
411	2x41	4x46	angiotensin_on	0	1.71	Yes	Yes	No	No	6	7
412	3x30	4x57	angiotensin_on	0	1.71	No	No	No	No	5	7
413	5x39	5x40	angiotensin_on	0	1.71	No	No	No	No	5	5
414	1x46	1x50	angiotensin_on	0	1.7	No	Yes	No	No	8	9
415	1x54	2x47	angiotensin_on	0	1.7	No	No	No	No	7	8
416	2x37	2x39	angiotensin_on	0	1.68	No	No	No	No	8	7
417	4x60	5x39	angiotensin_on	0	1.64	No	No	No	No	6	5
418	4x41	4x45	angiotensin_on	0	1.59	No	No	No	No	4	5
419	1x40	1x41	angiotensin_on	0	1.55	No	No	No	No	5	5
420	1x37	1x41	angiotensin_on	0	1.52	No	No	No	No	6	5
421	2x38	4x39	angiotensin_on	0	1.52	No	No	No	No	7	1
422	1x48	1x49	angiotensin_on	0	1.51	No	No	No	No	4	7
423	4x38	4x40	angiotensin_on	0	1.47	No	No	No	No	7	4
424	4x47	4x48	angiotensin_on	0	1.47	No	No	No	No	4	3
425	5x56	5x60	angiotensin_on	0	1.47	No	No	No	No	4	3
426	5x67	I3	angiotensin_on	0	1.45	No	No	No	Yes	4	0
427	8x55	8x59	angiotensin_on	0	1.41	No	No	No	No	3	0
428	8x55	8x58	angiotensin_on	0	1.38	No	No	No	No	3	6
429	5x68	I3	angiotensin_on	0	1.33	No	No	No	Yes	0	0
430	I2x51	I2x54	angiotensin_on	0	1.24	No	No	No	No	6	4
431	3x52	I2x56	angiotensin_on	0	1.21	No	No	No	No	5	4
432	I2x55	I2x56	angiotensin_on	0	1.21	No	No	No	No	4	4
433	6x29	6x31	angiotensin_on	0	1.19	No	No	No	No	0	4
434	8x59	8x60	angiotensin_on	0	1.19	No	No	No	No	0	0

Orange: nodes, hubs and links specific of angiotensin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of angiotensin_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	angiotensin_off Avg Int. Strength	angiotensin_on Avg Int. Strength	angiotensin_off Num Of Links	angiotensin_on Num Of Links	ConSurf
1	1x43	angiotensin_off	6.18625	7.70667	4	3	6
2	1x47	angiotensin_off	3.64	3.14	4	3	6
3	I1x50	angiotensin_off	3.843	4.27	5	2	7
4	2x40	angiotensin_off	3.8475	5.15667	4	3	8
5	2x44	angiotensin_off	6.78875	4.19667	4	3	5
6	2x53	angiotensin_off	10.975	1.56	5	1	6
7	3x50	angiotensin_off	4.67	7.715	4	2	9
8	5x49	angiotensin_off	5.36	1.44	4	1	6
9	5x54	angiotensin_off	6.4225	4.83	4	2	8
10	6x30	angiotensin_off	6.25125	6.51333	4	3	6
11	6x37	angiotensin_off	5.23125	4.75	4	2	7
12	6x44	angiotensin_off	6.75	4.41667	5	3	9
13	6x63	angiotensin_off	2.735	1.49	4	1	1
14	E3	angiotensin_off	5.6025	6.76667	4	3	1
15	7x36	angiotensin_off	2.56	2.94	4	1	6
16	7x42	angiotensin_off	7.492	6.34333	5	3	7
17	7x46	angiotensin_off	11.6112	4.63	4	1	9
18	7x52	angiotensin_off	5.16	7.28	4	2	8
19	Lig	Shared	12.385	13.0424	9	21	0
20	NT	Shared	8.32	20.9214	10	7	4
21	1x35	Shared	5.1175	3.885	4	6	6
22	1x39	Shared	6.714	5.398	5	5	7
23	1x60	Shared	2.54625	6.816	4	5	4
24	2x41	Shared	1.955	3.2175	4	4	6
25	2x42	Shared	5.929	5.04	5	5	7
26	2x50	Shared	8.0875	5.61	4	5	9
27	2x57	Shared	4.9	5.73	4	4	8
28	2x60	Shared	10.3	7.2025	5	4	7
29	E1	Shared	5.685	8.076	5	5	4
30	E1x50	Shared	8.16917	11.054	6	5	9
31	E1x52	Shared	8.826	7.568	5	5	6
32	3x34	Shared	4.918	4.4075	5	4	5
33	3x51	Shared	6.338	7.086	5	5	8
34	4x50	Shared	4.87875	5.7175	4	4	9
35	E2	Shared	13.8864	29.843	11	10	4
36	5x47	Shared	7.2375	5.795	4	4	8
37	5x50	Shared	2.7675	3.1325	4	4	8
38	5x58	Shared	7.3525	5.368	4	5	9
39	6x45	Shared	9.405	8.585	4	4	5
40	6x48	Shared	9.66125	4.906	4	5	8
41	1x28	angiotensin_on	9.16667	7.3075	3	4	4
42	1x46	angiotensin_on	3.42	1.8025	1	4	8
43	1x53	angiotensin_on	7.265	2.73	2	4	9
44	2x46	angiotensin_on	3.76	4.3125	2	4	9
45	2x63	angiotensin_on	6.49	7.5575	3	4	5
46	3x37	angiotensin_on	5.51167	5.62	3	5	7
47	I2x57	angiotensin_on	4.8	5.82	1	5	6
48	E2x52	angiotensin_on	11.1617	8.0725	3	4	4
49	5x43	angiotensin_on	3.1	11.98	2	4	5
50	5x62	angiotensin_on	5.20833	5.268	3	5	5
51	I3	angiotensin_on	0	3.99875	0	8	0
52	6x34	angiotensin_on	6.4025	6.678	2	5	6
53	6x43	angiotensin_on	6.89667	7.275	3	4	6
54	6x49	angiotensin_on	2.94667	5.2025	3	4	5
55	6x51	angiotensin_on	7.88333	6.46	3	6	6
56	7x53	angiotensin_on	7.945	5.706	3	5	9
57	8x50	angiotensin_on	1.41	4.1075	2	4	8
58	8x53	angiotensin_on	4.58	7.37	2	6	5

Orange: nodes, hubs and links specific of angiotensin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of angiotensin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	angiotensin_off Recurrence	angiotensin_on Recurrence	angiotensin_off Hub1?	angiotensin_on Hub1?	angiotensin_off Hub2?	angiotensin_on Hub2?	ConSurf1	ConSurf2
1	1x39	Lig	angiotensin_off	17.5875	0	Yes	Yes	Yes	Yes	7	0
2	7x42	Lig	angiotensin_off	75.701	0	Yes	No	Yes	Yes	7	0
3	1x35	1x39	angiotensin_off	13.5895	0.684913	Yes	Yes	Yes	Yes	6	7
4	E3	NT	angiotensin_off	16.6142	0	Yes	No	Yes	Yes	1	4
5	E2x52	Lig	angiotensin_off	43.6195	8.94339	No	Yes	Yes	Yes	4	0
6	E2	E2x52	angiotensin_off	38.1707	0.492611	Yes	Yes	No	Yes	4	4
7	E2	NT	angiotensin_off	28.5285	0.297674	Yes	Yes	Yes	Yes	4	4
8	1x43	2x57	angiotensin_off	17.2546	7.88704	Yes	No	Yes	Yes	6	8
9	2x53	2x57	angiotensin_off	23.93	0	Yes	No	Yes	Yes	6	8
10	2x53	7x46	angiotensin_off	29.5235	0	Yes	No	Yes	No	6	9
11	2x50	7x46	angiotensin_off	34.6069	2.57369	Yes	Yes	Yes	No	9	9
12	6x48	7x42	angiotensin_off	73.2407	0	Yes	Yes	Yes	No	8	7
13	3x43	6x44	angiotensin_off	47.281	0	No	No	Yes	No	8	9
14	3x43	6x41	angiotensin_off	46.9735	0	No	No	No	No	8	8
15	5x58	6x41	angiotensin_off	46.6479	1.06425	Yes	Yes	No	No	9	8
16	3x46	6x37	angiotensin_off	69.6009	0	No	No	Yes	No	9	7
17	2x43	3x46	angiotensin_off	12.4643	1.7597	No	No	No	No	8	9
18	2x43	7x53	angiotensin_off	10.9845	0	No	No	No	Yes	8	9
19	6x44	6x45	angiotensin_off	69.0401	0	Yes	No	Yes	Yes	9	5
20	5x54	6x45	angiotensin_off	66.2614	0	Yes	No	Yes	Yes	8	5
21	5x54	5x58	angiotensin_off	51.8362	0	Yes	No	Yes	Yes	8	9
22	2x42	3x46	angiotensin_off	58.0882	3.51677	Yes	Yes	No	No	7	9
23	2x42	4x42	angiotensin_off	37.505	0	Yes	Yes	No	No	7	7
24	2x41	4x42	angiotensin_off	35.9673	1.1143	Yes	Yes	No	No	6	7
25	2x41	I1x50	angiotensin_off	31.3108	0	Yes	Yes	Yes	No	6	7
26	1x58	I1x50	angiotensin_off	20.0984	0	No	No	Yes	No	4	7
27	1x58	1x59	angiotensin_off	18.5933	2.57633	No	No	No	No	4	4
28	1x55	1x59	angiotensin_off	16.9652	2.57633	No	No	No	No	3	4
29	1x55	1x56	angiotensin_off	13.6872	0	No	No	No	No	3	7
30	1x56	1x60	angiotensin_off	12.0373	0	No	No	Yes	Yes	7	4
31	3x50	6x37	angiotensin_off	34.4224	0	Yes	No	Yes	No	9	7
32	3x49	3x50	angiotensin_off	11.1907	0	No	No	Yes	No	8	9
33	2x42	4x46	angiotensin_off	18.2496	0	Yes	Yes	No	No	7	7
34	2x45	4x46	angiotensin_off	16.6178	5.43189	No	No	No	No	9	7
35	7x45	7x46	angiotensin_off	28.8433	0	No	No	Yes	No	9	9
36	7x45	7x49	angiotensin_off	22.8626	0	No	No	No	No	9	9
37	2x60	Lig	angiotensin_off	24.5414	5.12631	Yes	Yes	Yes	Yes	7	0
38	2x60	E1x50	angiotensin_off	13.7776	0	Yes	Yes	Yes	Yes	7	9
39	E1x50	E1x52	angiotensin_off	10.3803	5.60048	Yes	Yes	Yes	Yes	9	6
40	2x46	3x42	angiotensin_off	30.8586	0	No	Yes	No	No	9	7
41	3x42	4x49	angiotensin_off	28.4923	7.06515	No	No	No	No	7	7
42	3x41	4x49	angiotensin_off	26.1189	0	No	No	No	No	5	7
43	3x44	5x54	angiotensin_off	13.1191	0	No	No	Yes	No	7	8
44	3x44	5x50	angiotensin_off	10.1994	3.1585	No	No	Yes	Yes	7	8
45	3x50	6x30	angiotensin_off	21.0572	0	Yes	No	Yes	No	9	6
46	3x47	5x57	angiotensin_off	11.3861	1.09586	No	No	No	No	9	7
47	3x51	5x57	angiotensin_off	10.4164	0	Yes	Yes	No	No	8	7
48	3x54	6x30	angiotensin_off	13.206	0	No	No	Yes	No	8	6
49	3x41	4x52	angiotensin_off	14.6062	1.1143	No	No	No	No	5	4
50	4x48	4x52	angiotensin_off	12.1893	0	No	No	No	No	3	4
51	6x40	7x49	angiotensin_off	10.9592	0	No	No	No	No	8	9
52	7x38	Lig	angiotensin_off	11.1654	6.60151	No	No	Yes	Yes	6	0
53	2x53	7x42	angiotensin_off	18.9153	0	Yes	No	Yes	No	6	7
54	6x44	7x45	angiotensin_off	45.32	0	Yes	No	No	No	9	9
55	6x44	6x48	Shared	74.1199	82.0553	Yes	No	Yes	Yes	9	8
56	5x58	6x37	Shared	100	49.9144	Yes	Yes	Yes	No	9	7
57	2x45	4x50	Shared	14.9788	12.9633	No	No	Yes	Yes	9	9
58	2x46	2x50	Shared	33.2176	53.5997	No	Yes	Yes	Yes	9	9
59	2x50	7x49	Shared	16.4948	53.4628	Yes	Yes	No	No	9	9
60	3x34	4x50	Shared	10.1125	15.3421	Yes	Yes	Yes	Yes	5	9
61	7x35	Lig	angiotensin_on	0	10.7452	No	No	Yes	Yes	5	0
62	E2	Lig	angiotensin_on	0	11.5777	Yes	Yes	Yes	Yes	4	0
63	2x57	7x42	angiotensin_on	0	11.3037	Yes	Yes	Yes	No	8	7
64	3x36	7x42	angiotensin_on	0	10.9929	No	No	Yes	No	7	7
65	3x36	Lig	angiotensin_on	0	69.4002	No	No	Yes	Yes	7	0
66	1x50	2x50	angiotensin_on	9.76519	100	No	No	Yes	Yes	9	9
67	2x46	7x53	angiotensin_on	0	54.5955	No	Yes	No	Yes	9	9
68	3x50	7x53	angiotensin_on	0	55.2093	Yes	No	No	Yes	9	9
69	3x50	5x58	angiotensin_on	0	55.5201	Yes	No	Yes	Yes	9	9
70	3x47	5x58	angiotensin_on	3.11516	90.7958	No	No	Yes	Yes	9	9
71	3x47	5x54	angiotensin_on	9.22971	90.2374	No	No	Yes	No	9	8
72	5x54	6x44	angiotensin_on	0	89.9739	Yes	No	Yes	No	8	9
73	3x36	6x48	angiotensin_on	1.38934	76.3521	No	No	Yes	Yes	7	8
74	7x49	7x53	angiotensin_on	0	54.5771	No	No	No	Yes	9	9
75	6x40	7x53	angiotensin_on	0	55.9864	No	No	No	Yes	8	9
76	5x58	6x40	angiotensin_on	0	57.3773	Yes	Yes	No	No	9	8
77	1x50	7x50	angiotensin_on	4.89526	80.9278	No	No	No	No	9	9
78	1x53	7x55	angiotensin_on	0	46.7269	No	Yes	No	No	9	6
79	1x53	7x50	angiotensin_on	0	73.6888	No	Yes	No	No	9	9
80	1x53	1x57	angiotensin_on	0	20.4605	No	Yes	No	No	9	7
81	1x60	8x53	angiotensin_on	4.43938	21.9673	Yes	Yes	No	Yes	4	5
82	8x50	8x53	angiotensin_on	0	32.0487	No	Yes	No	Yes	8	5
83	7x55	8x50	angiotensin_on	0	39.5854	No	No	No	Yes	6	8
84	1x57	2x44	angiotensin_on	0.0651254	17.921	No	No	Yes	No	7	5
85	2x40	I1x50	angiotensin_on	5.07616	10.2711	Yes	No	Yes	No	8	7
86	2x44	I1x50	angiotensin_on	3.29607	12.8263	Yes	No	Yes	No	5	7
87	3x34	4x53	angiotensin_on	1.7005	19.3198	Yes	Yes	No	No	5	8
88	3x41	4x53	angiotensin_on	0	20.197	No	No	No	No	5	8
89	3x37	3x41	angiotensin_on	9.30207	21.9515	No	Yes	No	No	7	5
90	3x37	Lig	angiotensin_on	0	24.051	No	Yes	Yes	Yes	7	0
91	2x42	4x45	angiotensin_on	1.7005	12.0887	Yes	Yes	No	No	7	5
92	3x51	5x61	angiotensin_on	0	30.555	Yes	Yes	No	No	8	8
93	5x61	5x65	angiotensin_on	0	31.1925	No	No	No	No	8	8
94	5x65	6x34	angiotensin_on	0	32.8232	No	No	No	Yes	8	6
95	5x62	6x34	angiotensin_on	6.53786	45.4783	No	Yes	No	Yes	5	6
96	5x62	6x37	angiotensin_on	0	49.2795	No	Yes	Yes	No	5	7
97	3x52	I2x57	angiotensin_on	0	24.0115	No	No	No	Yes	5	6
98	2x38	I2x57	angiotensin_on	0	14.4727	No	No	No	Yes	7	6
99	4x41	4x45	angiotensin_on	0	10.4923	No	No	No	No	4	5
100	5x51	6x44	angiotensin_on	0	11.3406	No	No	Yes	No	6	9
101	1x46	1x50	angiotensin_on	0	17.921	No	Yes	No	No	8	9
102	1x45	1x46	angiotensin_on	0	10.2711	No	No	No	Yes	5	8
103	3x51	3x52	angiotensin_on	5.45968	25.031	Yes	Yes	No	No	8	5

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x39	Lig	angiotensin_off	9.995	0	0	0	1	0
2x60	Lig	Shared	27.54	16.21	1	1	1	0
3x32	Lig	Shared	15.23	3.93	1	1	1	0
3x33	Lig	Shared	13.42	5.28	0	1	1	0
4x65	Lig	angiotensin_off	24.47	0	0	0	1	0
E2x52	Lig	Shared	5.88	6.19	1	1	1	0
7x38	Lig	Shared	9.15	6.41	0	1	1	0
7x42	Lig	angiotensin_off	3.76	0	1	0	1	0
NT	NT	Shared	18.76	17	1	1	1	1
E2	NT	Shared	9.17	74.91	1	1	1	1
E3	NT	angiotensin_off	3.675	0	1	0	2	1
7x24	NT	Shared	7.28	7.28	0	1	2	1
7x27	NT	angiotensin_off	4.505	0	1	0	2	1
7x31	NT	Shared	6.31	6.31	0	1	1	1
1x32	NT	angiotensin_off	5.34	0	1	0	2	1
E1	NT	Shared	6.175	7.2	1	1	1	1
1x32	E1	Shared	6.705	4.13	1	0	2	1
1x35	1x39	Shared	7.25	6.04	0	0	2	1
1x35	2x64	angiotensin_off	8.36	0	0	0	2	2
1x39	2x57	Shared	7.615	8.21	0	0	1	2
1x39	7x39	Shared	5.375	4.03	0	0	1	2
2x53	2x57	angiotensin_off	6.7	0	1	0	2	2
2x53	3x32	angiotensin_off	6.55	0	1	0	2	1
2x53	3x35	Shared	13.29	1.56	1	0	2	2
2x53	7x42	angiotensin_off	14.44	0	1	0	2	1
2x60	2x63	Shared	4.82	3.86	1	1	1	1
2x60	E1x50	angiotensin_off	10.31	0	1	1	1	2
2x60	3x28	Shared	3.89	3.89	1	1	1	2
2x60	3x29	angiotensin_off	4.94	0	1	1	1	2
2x63	E1	Shared	6.45	10.92	1	1	1	1
2x63	E1x50	Shared	8.2	10.61	1	1	1	2
2x64	E1	Shared	5.62	7.49	0	0	2	1
7x35	E1	angiotensin_off	3.475	0	0	1	1	1
E1x49	E2	Shared	14.415	5.01	0	1	2	1
E1x50	E2x50	Shared	11.1	15.67	1	1	2	2
3x22	3x26	Shared	4.2	8.39	1	1	2	2
3x22	E2	Shared	14.71	12.72	1	1	2	1
3x26	E2	angiotensin_off	6.295	0	1	0	2	1
3x29	4x65	Shared	13.835	15.81	0	0	2	1
3x32	7x42	Shared	5.05	3.79	1	1	1	1
3x35	7x42	angiotensin_off	6.975	0	1	0	2	1
3x36	6x48	Shared	13.67	3.42	0	1	1	2
3x37	3x41	Shared	3.61	6.19	0	1	1	2
3x37	4x56	Shared	9.34	8.01	0	1	1	2
3x37	5x43	Shared	3.585	4.78	0	1	1	1
4x64	E2x52	angiotensin_off	14.71	0	0	0	2	1
E2	E2	Shared	40.29	65.49	1	1	1	1
E2	E2x52	Shared	12.895	4.13	1	1	1	1
6x62	E2	Shared	9.585	18.18	1	1	2	1
6x48	7x42	angiotensin_off	7.235	0	0	0	2	1
6x51	6x55	Shared	5.475	6.85	0	1	1	2
6x51	7x37	Shared	8.895	8.21	0	1	1	2
6x51	7x38	Shared	9.28	3.98	0	1	1	1
6x58	6x62	angiotensin_off	9.14	0	0	0	1	2
6x58	7x34	angiotensin_off	5.545	0	0	0	1	1
6x61	7x30	Shared	4.61	4.61	0	1	1	2
1x39	2x61	Shared	3.335	2.67	0	0	1	2
6x61	7x27	angiotensin_off	3.25	0	0	1	1	2
7x28	NT	angiotensin_off	3.225	0	1	4	2	1
5x40	5x43	angiotensin_off	2.615	0	0	0	2	1
5x35	E2	angiotensin_off	2.165	0	0	0	2	1
5x36	E2	Shared	2.085	13.08	0	1	2	1
4x61	Lig	angiotensin_off	2.02	0	0	0	1	0
3x30	4x61	angiotensin_off	1.79	0	0	0	2	1
2x56	3x28	angiotensin_off	1.68	0	0	0	2	2
5x39	5x42	angiotensin_off	1.475	0	0	0	2	2
E2	E2x51	angiotensin_off	0.85	0	1	1	1	1
Lig	NT	angiotensin_on	0	16.75	1	1	0	1
1x35	7x35	angiotensin_on	0	5.08	0	0	2	1
1x39	7x38	angiotensin_on	0	6.04	0	0	1	1
2x56	2x60	angiotensin_on	0	4.85	0	0	2	1
2x57	7x42	angiotensin_on	0	8.21	0	0	2	1
2x63	Lig	angiotensin_on	0	4.84	1	1	1	0
E1	Lig	angiotensin_on	0	10.64	1	1	1	0
3x33	4x57	angiotensin_on	0	6.52	0	1	1	2
3x33	4x61	angiotensin_on	0	3.42	0	1	1	1
3x36	7x42	angiotensin_on	0	7.03	0	1	1	1
3x36	Lig	angiotensin_on	0	4.87	0	1	1	0
3x37	5x42	angiotensin_on	0	4.99	0	1	1	2
3x37	Lig	angiotensin_on	0	4.13	0	1	1	0
4x64	5x36	angiotensin_on	0	4.58	0	0	2	2
4x65	E2x52	angiotensin_on	0	17.1	0	0	1	1
E2	E2x50	angiotensin_on	0	5.12	1	1	1	2
E2	Lig	angiotensin_on	0	34.3	1	1	1	0
E2x51	Lig	angiotensin_on	0	4.95	0	0	1	0
5x39	E2x52	angiotensin_on	0	4.87	0	0	2	1
5x43	6x51	angiotensin_on	0	7.86	0	1	1	1
5x43	6x55	angiotensin_on	0	10.51	0	1	1	2
5x43	Lig	angiotensin_on	0	24.77	0	1	1	0
6x51	7x34	angiotensin_on	0	3.94	0	1	1	1
6x51	Lig	angiotensin_on	0	7.92	0	1	1	0
6x58	Lig	angiotensin_on	0	14.05	0	0	1	0
6x61	E3	angiotensin_on	0	5.89	0	1	1	2
6x61	Lig	angiotensin_on	0	5.01	0	1	1	0
7x24	7x27	angiotensin_on	0	3.61	0	1	2	2
7x31	Lig	angiotensin_on	0	22.07	0	1	1	0
7x34	Lig	angiotensin_on	0	13.98	0	1	1	0
7x35	Lig	angiotensin_on	0	7.63	0	1	1	0
4x64	5x35	angiotensin_on	0	2.57	0	0	2	2
3x30	4x57	angiotensin_on	0	1.71	0	0	2	2
5x39	5x40	angiotensin_on	0	1.71	0	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	angiotensin_off	at1_off
	angiotensin_on	at1_on

Network Difference
Value	angiotensin_off	angiotensin_on
I_min	3.455	3.07
Number of Linked Nodes	253	253
Number of Specific Nodes	15 (5.93%)	15 (5.93%)
Number of Shared Nodes	238 (94.07%)	238 (94.07%)
Number of Links	284	294
Number of Specific Links	140 (49.30%)	150 (51.02%)
Number of Shared Links	144 (50.70%)	144 (48.98%)
Number of Hubs	40	40
Number of Specific Hubs	18 (45.00%)	18 (45.00%)
Number of Shared Hubs	22 (55.00%)	22 (55.00%)
Average % Shared Neighbours (Jaccard)	36.04
Average % Shared Neighbours (Otsuka)	45.41
Average % Shared Neighbours (Overlap Coefficient)	55.24
Average % Shared Cliques (k3-6)	76.11
Graphlets Similarity	0.54795

Paths Difference
Value	angiotensin_off	angiotensin_on
Number Of Nodes in MetaPath	59	49
Specific Nodes in MetaPath	35 (59.32%)	25 (51.02%)
Shared Nodes in MetaPath	238 (94.07%)	238 (94.07%)
Number Of Links MetaPath	60	49
Specific Links in MetaPath	54 (90.00%)	43 (87.76%)
Shared Links in MetaPath	144 (50.70%)	144 (50.70%)
Number of Shortest Paths	53737	68830
Length Of Smallest Path	3	3
Average Path Length	13.4631	15.3139
Length of Longest Path	29	33
Minimum Path Strength	0.7425	1.21
Average Path Strength	6.54261	5.63724
Maximum Path Strength	21.385	46.545
Minimum Path Correlation	0.705	0.7
Average Path Correlation	0.908626	0.93226
Maximum Path Correlation	0.985	1
Minimum % Of Corr. Nodes	3.7037	4.34783
Average % Of Corr. Nodes	39.8341	46.8589
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	53.7991	42.1279
Maximum Path Hubs %	100	100

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