psnGPCR

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Orange: nodes, hubs and links specific of 5ht_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht_off Int. Strength	5ht_on Int. Strength	5ht_off Hub1?	5ht_on Hub1?	5ht_off Hub2?	5ht_on Hub2?	ConSurf1	ConSurf2
1	1x46	2x54	5ht_off	100	0	No	No	No	No	7	6
2	1x46	2x57	5ht_off	100	0	No	No	Yes	Yes	7	8
3	1x57	2x40	5ht_off	100	0	No	No	No	No	7	9
4	8x49	I1x50	5ht_off	100	0	No	No	Yes	No	6	8
5	2x41	4x39	5ht_off	100	0	Yes	No	No	No	4	4
6	2x42	4x46	5ht_off	100	0	No	Yes	No	No	8	8
7	2x43	7x53	5ht_off	100	0	No	No	No	Yes	8	9
8	2x53	2x56	5ht_off	100	0	No	No	No	No	7	8
9	2x57	7x39	5ht_off	100	0	Yes	Yes	Yes	Yes	8	6
10	2x60	7x42	5ht_off	100	0	Yes	No	Yes	Yes	7	7
11	2x61	7x39	5ht_off	100	0	No	No	Yes	Yes	6	6
12	7x35	E1	5ht_off	100	0	No	No	No	No	4	3
13	3x25	E2	5ht_off	100	0	No	No	Yes	Yes	9	3
14	3x37	Lig	5ht_off	100	0	No	No	Yes	Yes	7	0
15	3x40	5x50	5ht_off	100	0	No	No	No	No	8	9
16	3x40	6x44	5ht_off	100	0	No	No	Yes	Yes	8	9
17	3x41	3x44	5ht_off	100	0	No	No	No	No	6	6
18	3x43	6x44	5ht_off	100	0	No	No	Yes	Yes	8	9
19	3x44	5x54	5ht_off	100	0	No	No	No	No	6	8
20	3x50	6x37	5ht_off	100	0	Yes	No	No	No	9	8
21	3x54	5x64	5ht_off	100	0	No	No	No	No	9	6
22	I2x54	I2x56	5ht_off	100	0	No	No	No	No	6	4
23	4x52	4x56	5ht_off	100	0	Yes	No	No	No	5	6
24	5x44	Lig	5ht_off	100	0	No	No	Yes	Yes	6	0
25	5x51	6x45	5ht_off	100	0	No	No	No	No	6	6
26	5x54	6x41	5ht_off	100	0	No	No	Yes	No	8	8
27	5x58	5x62	5ht_off	100	0	Yes	Yes	No	No	9	5
28	6x40	7x52	5ht_off	100	0	No	No	No	No	8	8
29	6x44	7x45	5ht_off	100	0	Yes	Yes	Yes	No	9	9
30	6x48	6x51	5ht_off	100	0	Yes	Yes	Yes	Yes	8	7
31	6x48	Lig	5ht_off	100	0	Yes	Yes	Yes	Yes	8	0
32	6x51	6x55	5ht_off	100	0	Yes	Yes	Yes	No	7	7
33	6x55	7x34	5ht_off	100	0	Yes	No	Yes	Yes	7	3
34	E3	E3	5ht_off	100	0	Yes	Yes	Yes	Yes	3	3
35	7x38	Lig	5ht_off	100	0	No	No	Yes	Yes	6	0
36	7x42	Lig	5ht_off	100	0	Yes	Yes	Yes	Yes	7	0
37	8x48	8x52	5ht_off	100	0	No	No	No	No	5	4
38	4x38	I2x53	5ht_off	100	0	Yes	No	Yes	Yes	7	7
39	6x37	6x41	5ht_off	100	0	No	No	Yes	No	8	8
40	6x44	6x45	5ht_off	100	0	Yes	Yes	No	No	9	6
41	5x66	6x31	5ht_off	100	0	Yes	Yes	Yes	No	6	5
42	2x60	2x64	5ht_off	100	0	Yes	No	No	No	7	5
43	NT	NT	5ht_off	100	0	Yes	No	Yes	No	0	0
44	1x32	NT	5ht_off	100	0	No	No	Yes	No	6	0
45	1x49	7x51	5ht_off	100	0	Yes	No	No	No	8	6
46	I2x50	I2x51	5ht_off	100	0	No	No	No	No	8	7
47	2x67	NT	5ht_off	100	0	No	No	Yes	No	5	0
48	2x63	E2	5ht_off	100	0	No	No	Yes	Yes	5	3
49	3x55	5x60	5ht_off	100	0	No	No	No	No	6	5
50	4x63	5x36	5ht_off	100	0	No	No	Yes	No	5	5
51	6x26	6x29	5ht_off	100	0	No	No	No	No	5	6
52	7x33	7x36	5ht_off	100	0	No	No	No	No	4	4
53	8x55	CT	5ht_off	100	0	No	No	Yes	No	3	5
54	3x49	4x38	5ht_off	100	0	Yes	Yes	Yes	No	9	7
55	5x66	5x68	5ht_off	100	0	Yes	Yes	No	No	6	7
56	5x67	6x31	5ht_off	100	0	No	No	Yes	No	5	5
57	5x36	5x39	5ht_off	33.3333	0	Yes	No	No	No	5	7
58	1x50	2x47	5ht_off	66.6667	0	No	Yes	No	No	9	9
59	6x40	7x49	5ht_off	66.6667	0	No	No	Yes	Yes	8	9
60	3x50	3x53	5ht_off	35.1852	0	Yes	No	No	No	9	8
61	5x64	5x68	5ht_off	44.4444	0	No	No	No	No	6	7
62	7x53	8x50	5ht_off	66.6667	0	No	Yes	Yes	Yes	9	8
63	3x51	3x52	5ht_off	35.1852	0	Yes	Yes	No	No	8	5
64	2x52	2x551	5ht_off	40.7407	0	No	No	No	No	7	5
65	3x30	4x62	5ht_off	33.3333	0	No	No	No	No	6	5
66	2x66	E1x51	5ht_off	33.3333	0	No	No	No	No	4	3
67	1x47	2x55	5ht_off	33.3333	0	No	No	No	No	5	4
68	1x52	1x56	5ht_off	33.3333	0	No	No	No	No	6	7
69	1x56	8x50	5ht_off	33.3333	0	No	No	Yes	Yes	7	8
70	2x65	7x39	5ht_off	33.3333	0	No	No	Yes	Yes	5	6
71	6x58	7x30	5ht_off	66.6667	0	Yes	No	No	No	4	4
72	3x49	4x45	5ht_off	33.3333	0	Yes	Yes	No	No	9	6
73	3x50	6x33	5ht_off	48.1481	0	Yes	No	No	No	9	8
74	7x54	8x54	5ht_off	33.3333	0	No	No	No	No	7	6
75	2x39	4x38	5ht_off	33.3333	0	No	No	Yes	No	8	7
76	1x47	2x51	5ht_off	11.1111	0	No	No	No	No	5	7
77	1x43	2x58	5ht_off	37.037	0	No	No	No	No	6	8
78	1x49	7x54	5ht_off	33.3333	0	Yes	No	No	No	8	7
79	1x33	NT	5ht_off	33.3333	0	No	No	Yes	No	5	0
80	I2x53	I2x56	5ht_off	33.3333	0	Yes	Yes	No	No	7	4
81	4x39	4x43	5ht_off	66.6667	0	No	No	No	No	4	4
82	I2x55	I2x56	5ht_off	33.3333	0	No	No	No	No	4	4
83	1x42	2x57	5ht_off	5.55556	0	No	No	Yes	Yes	7	8
84	6x39	7x52	5ht_off	35.1852	0	No	No	No	No	6	8
85	7x35	NT	5ht_off	33.3333	0	No	No	Yes	No	4	0
86	6x49	6x50	5ht_off	33.3333	0	No	No	No	No	6	9
87	1x28	NT	5ht_off	33.3333	0	No	No	Yes	No	3	0
88	6x58	6x59	5ht_off	33.3333	0	Yes	No	No	No	4	5
89	5x58	5x59	5ht_off	33.3333	0	Yes	Yes	No	No	9	1
90	6x57	E3	5ht_off	33.3333	0	No	No	Yes	Yes	4	3
91	6x35	7x56	5ht_off	44.4444	0	No	No	No	Yes	7	7
92	2x41	4x46	5ht_off	33.3333	0	Yes	No	No	No	4	8
93	5x36	5x37	5ht_off	44.4444	0	Yes	No	No	No	5	4
94	2x62	E1x52	5ht_off	44.4444	0	No	No	Yes	No	4	5
95	3x21	E1x52	5ht_off	33.3333	0	No	No	Yes	No	7	5
96	5x66	5x69	5ht_off	33.3333	0	Yes	Yes	No	No	6	5
97	2x62	E1x51	5ht_off	22.2222	0	No	No	No	No	4	3
98	7x37	7x40	5ht_off	37.037	0	Yes	Yes	No	No	5	7
99	6x31	6x32	5ht_off	33.3333	0	Yes	No	No	No	5	8
100	1x28	1x29	5ht_off	33.3333	0	No	No	No	No	3	3
101	4x57	4x58	5ht_off	33.3333	0	Yes	No	No	No	7	0
102	1x42	7x43	5ht_off	33.3333	0	No	No	No	No	7	4
103	8x49	I1x49	5ht_off	33.3333	0	No	No	No	No	6	6
104	1x55	8x57	5ht_off	33.3333	0	No	No	Yes	No	4	4
105	7x32	NT	5ht_off	33.3333	0	No	No	Yes	No	1	0
106	5x65	6x34	5ht_off	0	0	No	No	No	No	8	7
107	8x53	8x57	5ht_off	33.3333	0	No	No	Yes	No	7	4
108	1x52	8x57	5ht_off	16.6667	0	No	No	Yes	No	6	4
109	3x21	3x23	5ht_off	11.1111	0	No	No	No	No	7	1
110	1x34	1x35	5ht_off	33.3333	0	No	No	No	No	4	3
111	4x64	5x36	5ht_off	33.3333	0	No	No	Yes	No	4	5
112	1x60	CT	5ht_off	33.3333	0	No	Yes	Yes	No	6	5
113	5x69	6x27	5ht_off	12.963	0	No	No	No	No	5	5
114	3x50	6x30	5ht_off	33.3333	0	Yes	No	No	Yes	9	8
115	5x65	6x31	5ht_off	11.1111	0	No	No	Yes	No	8	5
116	1x57	1x58	5ht_off	33.3333	0	No	No	No	No	7	1
117	7x27	E2	5ht_off	33.3333	0	No	No	Yes	Yes	3	3
118	6x28	6x32	5ht_off	0	0	No	No	No	No	6	8
119	1x30	1x31	5ht_off	0	0	No	No	No	No	1	3
120	1x40	1x43	5ht_off	0	0	No	No	No	No	3	6
121	5x45	5x46	5ht_off	33.3333	0	No	No	No	No	4	4
122	4x56	5x42	5ht_off	0	0	No	No	No	No	6	4
123	4x40	4x44	5ht_off	0	0	No	No	No	No	5	3
124	I2x51	I2x52	5ht_off	16.6667	0	No	No	No	No	7	5
125	6x42	6x46	5ht_off	33.3333	0	No	No	No	No	5	5
126	5x41	5x45	5ht_off	0	0	No	No	No	No	6	4
127	4x52	4x55	5ht_off	0	0	Yes	No	No	No	5	4
128	8x58	CT	5ht_off	0	0	No	No	Yes	No	6	5
129	7x29	7x33	5ht_off	11.1111	0	No	No	No	No	5	4
130	1x33	1x37	5ht_off	11.1111	0	No	No	No	No	5	4
131	8x59	CT	5ht_off	11.1111	0	No	No	Yes	No	4	5
132	1x35	1x38	5ht_off	0	0	No	No	No	No	3	4
133	5x52	5x55	5ht_off	0	0	No	No	No	No	3	5
134	4x47	4x51	5ht_off	0	0	No	No	No	No	2	4
135	1x27	1x30	5ht_off	3.7037	0	No	No	No	No	2	1
136	1x41	1x411	5ht_off	0	0	No	No	No	No	4	0
137	4x51	4x52	5ht_off	0	0	No	No	Yes	No	4	5
138	6x24	I3	5ht_off	0	0	No	No	No	No	0	0
139	6x24	6x27	5ht_off	0	0	No	No	No	No	0	5
140	1x39	2x61	Shared	100	100	No	No	No	No	6	6
141	1x39	7x39	Shared	100	100	No	No	Yes	Yes	6	6
142	1x43	2x57	Shared	100	100	No	No	Yes	Yes	6	8
143	1x46	7x47	Shared	100	100	No	No	No	No	7	6
144	1x49	7x50	Shared	100	45	Yes	No	No	No	8	9
145	1x50	2x50	Shared	100	100	No	Yes	Yes	Yes	9	9
146	1x50	7x50	Shared	100	100	No	Yes	No	No	9	9
147	1x52	8x54	Shared	100	50	No	No	No	No	6	6
148	1x54	2x48	Shared	100	100	No	No	No	No	6	6
149	1x60	I1x50	Shared	100	100	No	Yes	Yes	No	6	8
150	8x50	I1x50	Shared	100	100	Yes	Yes	Yes	No	8	8
151	2x37	2x40	Shared	100	100	No	No	No	No	7	9
152	2x42	3x46	Shared	100	100	No	Yes	No	No	8	9
153	2x45	3x42	Shared	100	100	No	No	Yes	Yes	9	8
154	2x45	4x46	Shared	100	100	No	No	No	No	9	8
155	2x45	4x50	Shared	100	100	No	No	Yes	Yes	9	9
156	2x46	2x50	Shared	100	100	No	Yes	Yes	Yes	9	9
157	2x46	7x49	Shared	100	100	No	Yes	Yes	Yes	9	9
158	2x49	4x50	Shared	100	62.5	No	No	Yes	Yes	8	9
159	2x50	3x39	Shared	100	58.3333	Yes	Yes	No	No	9	9
160	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
161	2x50	7x49	Shared	100	100	Yes	Yes	Yes	Yes	9	9
162	2x52	3x35	Shared	100	100	No	No	No	No	7	7
163	2x53	7x46	Shared	100	100	No	No	No	No	7	9
164	2x551	3x31	Shared	100	33.3333	No	No	No	No	5	5
165	2x56	3x32	Shared	100	100	No	No	No	No	8	8
166	2x56	7x42	Shared	100	100	No	No	Yes	Yes	8	7
167	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	8	7
168	2x59	3x28	Shared	100	100	No	No	No	No	4	5
169	2x60	7x39	Shared	100	55.5556	Yes	No	Yes	Yes	7	6
170	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	5	7
171	2x64	7x39	Shared	100	100	No	No	Yes	Yes	5	6
172	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	No	7	5
173	3x24	E1x50	Shared	100	100	No	No	Yes	Yes	5	7
174	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	7
175	3x28	E1x50	Shared	100	100	No	No	Yes	Yes	5	7
176	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	7	9
177	3x24	E1x52	Shared	100	100	No	No	Yes	No	5	5
178	3x22	E2	Shared	100	100	No	No	Yes	Yes	3	3
179	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
180	3x26	E2	Shared	100	37.5	No	No	Yes	Yes	6	3
181	3x29	E2x52	Shared	100	100	No	No	No	No	5	4
182	3x30	4x57	Shared	100	36.6667	No	No	Yes	No	6	7
183	3x32	7x42	Shared	100	100	No	No	Yes	Yes	8	7
184	3x32	Lig	Shared	100	100	No	No	Yes	Yes	8	0
185	3x33	4x57	Shared	100	100	No	No	Yes	No	6	7
186	3x33	Lig	Shared	100	100	No	No	Yes	Yes	6	0
187	3x34	4x57	Shared	100	100	No	No	Yes	No	6	7
188	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	8
189	3x36	Lig	Shared	100	100	No	No	Yes	Yes	7	0
190	3x37	4x53	Shared	100	100	No	No	No	No	7	8
191	3x37	5x461	Shared	100	100	No	No	No	No	7	6
192	3x38	4x50	Shared	100	100	No	No	Yes	Yes	8	9
193	3x41	5x50	Shared	100	100	No	No	No	No	6	9
194	3x42	4x49	Shared	100	100	Yes	Yes	No	No	8	6
195	3x42	4x50	Shared	100	100	Yes	Yes	Yes	Yes	8	9
196	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	6
197	3x51	5x57	Shared	100	100	Yes	Yes	No	No	8	5
198	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	5
199	3x56	I2x52	Shared	100	50	No	No	No	No	6	5
200	4x59	4x60	Shared	100	100	No	No	No	No	4	7
201	4x60	5x39	Shared	100	100	No	No	No	No	7	7
202	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
203	5x36	E2	Shared	100	100	Yes	No	Yes	Yes	5	3
204	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	4
205	E2x52	Lig	Shared	100	100	No	No	Yes	Yes	4	0
206	5x36	5x38	Shared	100	100	Yes	No	No	No	5	3
207	5x43	Lig	Shared	100	100	No	No	Yes	Yes	6	0
208	5x44	5x48	Shared	100	100	No	No	Yes	Yes	6	5
209	5x44	6x52	Shared	100	100	No	No	Yes	Yes	6	7
210	5x45	5x48	Shared	100	100	No	No	Yes	Yes	4	5
211	5x47	5x48	Shared	100	100	No	Yes	Yes	Yes	8	5
212	5x47	6x52	Shared	100	100	No	Yes	Yes	Yes	8	7
213	5x48	6x56	Shared	100	100	Yes	Yes	No	No	5	5
214	5x49	5x50	Shared	100	100	No	No	No	No	5	9
215	5x58	6x38	Shared	100	16.6667	Yes	Yes	No	No	9	6
216	6x36	7x56	Shared	100	100	No	No	No	Yes	8	7
217	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
218	6x47	7x45	Shared	100	100	No	No	Yes	No	8	9
219	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
220	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
221	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	8	9
222	6x50	7x37	Shared	100	100	No	No	Yes	Yes	9	5
223	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	7	7
224	6x51	7x34	Shared	100	100	Yes	Yes	Yes	Yes	7	3
225	6x51	7x38	Shared	100	100	Yes	Yes	No	No	7	6
226	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
227	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
228	6x54	7x37	Shared	100	100	No	No	Yes	Yes	5	5
229	6x55	Lig	Shared	100	100	Yes	No	Yes	Yes	7	0
230	7x33	7x37	Shared	100	58.3333	No	No	Yes	Yes	4	5
231	7x38	7x42	Shared	100	100	No	No	Yes	Yes	6	7
232	7x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
233	8x47	8x49	Shared	100	100	No	No	No	No	9	6
234	8x47	8x50	Shared	100	100	No	No	Yes	Yes	9	8
235	8x48	8x51	Shared	100	28.8889	No	No	No	No	5	9
236	2x46	3x42	Shared	100	100	No	Yes	Yes	Yes	9	8
237	5x47	5x51	Shared	100	100	No	Yes	No	No	8	6
238	5x58	6x41	Shared	100	100	Yes	Yes	Yes	No	9	8
239	5x62	5x66	Shared	100	100	No	No	Yes	Yes	5	6
240	1x47	2x54	Shared	100	38.8889	No	No	No	No	5	6
241	3x41	4x52	Shared	100	100	No	No	Yes	No	6	5
242	3x48	3x52	Shared	100	100	No	No	No	No	6	5
243	3x55	3x56	Shared	100	50	No	No	No	No	6	6
244	5x59	5x63	Shared	100	25.5556	No	No	No	No	1	4
245	7x45	7x49	Shared	100	100	Yes	No	Yes	Yes	9	9
246	7x43	7x48	Shared	100	47.2222	No	No	No	No	4	6
247	I2x53	I2x57	Shared	100	100	Yes	Yes	No	No	7	6
248	6x29	6x32	Shared	100	25	No	No	No	No	6	8
249	6x58	7x34	Shared	100	100	Yes	No	Yes	Yes	4	3
250	3x26	4x61	Shared	100	36.6667	No	No	No	No	6	6
251	3x45	4x45	Shared	100	50	No	No	No	No	7	6
252	3x49	I2x53	Shared	100	100	Yes	Yes	Yes	Yes	9	7
253	3x49	I2x57	Shared	100	100	Yes	Yes	No	No	9	6
254	3x52	I2x53	Shared	100	100	No	No	Yes	Yes	5	7
255	4x63	E2	Shared	100	100	No	No	Yes	Yes	5	3
256	6x54	7x34	Shared	66.6667	100	No	No	Yes	Yes	5	3
257	2x41	4x42	Shared	37.037	36.6667	Yes	No	No	No	4	7
258	1x57	2x44	Shared	33.3333	100	No	No	No	No	7	5
259	I1x48	I1x51	Shared	66.6667	28.8889	No	No	No	No	6	7
260	1x54	2x47	Shared	66.6667	21.3889	No	No	No	No	6	9
261	2x42	3x49	Shared	77.7778	100	No	Yes	Yes	Yes	8	9
262	2x38	4x39	Shared	33.3333	42.7778	No	No	No	No	5	4
263	2x60	3x28	Shared	35.1852	54.1667	Yes	No	No	No	7	5
264	3x51	5x61	Shared	33.3333	50	Yes	Yes	No	No	8	9
265	4x68	E2	Shared	33.3333	16.6667	No	No	Yes	Yes	4	3
266	3x47	5x57	Shared	33.3333	40	No	No	No	No	9	5
267	6x49	6x53	Shared	44.4444	45.5556	No	No	No	No	6	6
268	6x61	E3	Shared	33.3333	48.3333	No	No	Yes	Yes	3	3
269	2x55	2x551	Shared	12.963	33.3333	No	No	No	No	4	5
270	2x41	I1x51	Shared	66.6667	33.3333	Yes	No	No	No	4	7
271	E1x49	E2	Shared	44.4444	100	No	No	Yes	Yes	4	3
272	1x53	2x47	Shared	59.2593	100	No	No	No	No	9	9
273	3x44	5x53	Shared	66.6667	63.8889	No	No	No	No	6	6
274	1x45	7x47	Shared	33.3333	22.2222	No	No	No	No	4	6
275	6x58	E3	Shared	33.3333	100	Yes	No	Yes	Yes	4	3
276	7x26	7x29	Shared	33.3333	16.6667	No	No	No	No	1	5
277	5x51	5x55	Shared	44.4444	100	No	No	No	No	6	5
278	3x34	4x54	Shared	11.1111	29.1667	No	No	No	No	6	4
279	2x66	2x67	Shared	33.3333	11.6667	No	No	No	No	4	5
280	4x38	4x41	Shared	33.3333	33.3333	Yes	No	No	No	7	6
281	2x40	I1x50	Shared	33.3333	100	No	No	Yes	No	9	8
282	1x32	1x35	Shared	33.3333	19.4444	No	No	No	No	6	3
283	6x43	7x52	Shared	33.3333	45.5556	No	No	No	No	6	8
284	1x59	8x57	Shared	33.3333	100	No	No	Yes	No	5	4
285	6x35	6x39	Shared	33.3333	44.1667	No	No	No	No	7	6
286	6x25	6x29	Shared	33.3333	6.66667	No	No	No	No	5	6
287	1x36	2x65	Shared	35.1852	22.2222	No	No	No	No	6	5
288	4x44	4x48	Shared	0	8.33333	No	No	No	No	3	2
289	7x55	7x56	Shared	22.2222	38.8889	No	No	No	Yes	5	7
290	4x38	4x40	Shared	33.3333	34.1667	Yes	No	No	No	7	5
291	1x51	2x51	Shared	33.3333	58.3333	No	No	No	No	3	7
292	7x26	7x28	Shared	33.3333	16.6667	No	No	No	No	1	2
293	5x40	6x55	Shared	33.3333	33.3333	No	No	Yes	No	6	7
294	8x51	8x55	Shared	33.3333	0	No	No	No	No	9	3
295	6x41	6x42	Shared	0	9.72222	Yes	No	No	No	8	5
296	1x60	8x56	Shared	33.3333	23.3333	No	Yes	No	No	6	4
297	1x48	1x49	Shared	0	0	No	No	Yes	No	4	8
298	1x29	1x30	Shared	33.3333	0	No	No	No	No	3	1
299	4x65	E2	Shared	22.2222	16.6667	No	No	Yes	Yes	7	3
300	8x60	CT	Shared	22.2222	0	No	No	Yes	No	8	5
301	3x26	4x66	Shared	11.1111	12.5	No	No	No	No	6	5
302	5x56	5x60	Shared	0	100	No	No	No	No	5	5
303	3x23	3x27	Shared	0	28.8889	No	No	No	No	1	4
304	1x41	1x45	Shared	11.1111	47.2222	No	No	No	No	4	4
305	7x31	7x35	Shared	11.1111	50	No	No	No	No	2	4
306	1x40	1x44	Shared	0	0	No	No	No	No	3	4
307	5x41	6x60	Shared	11.1111	28.8889	No	No	No	No	6	4
308	4x63	4x67	Shared	0	0	No	No	No	No	5	6
309	1x50	2x51	5ht_on	0	100	No	Yes	No	No	9	7
310	2x40	8x50	5ht_on	0	100	No	No	Yes	Yes	9	8
311	2x46	3x43	5ht_on	0	100	No	Yes	No	No	9	8
312	2x53	3x35	5ht_on	0	100	No	No	No	No	7	7
313	2x54	2x57	5ht_on	0	100	No	No	Yes	Yes	6	8
314	2x64	7x35	5ht_on	0	100	No	No	No	No	5	4
315	2x66	E1x49	5ht_on	0	100	No	No	No	No	4	4
316	3x40	6x48	5ht_on	0	100	No	No	Yes	Yes	8	8
317	3x41	4x49	5ht_on	0	100	No	No	No	No	6	6
318	3x43	7x49	5ht_on	0	100	No	No	Yes	Yes	8	9
319	3x43	7x53	5ht_on	0	100	No	No	No	Yes	8	9
320	3x46	3x50	5ht_on	0	100	No	No	Yes	No	9	9
321	3x46	7x53	5ht_on	0	100	No	No	No	Yes	9	9
322	3x47	5x58	5ht_on	0	100	No	No	Yes	Yes	9	9
323	3x50	7x53	5ht_on	0	100	Yes	No	No	Yes	9	9
324	4x38	4x39	5ht_on	0	100	Yes	No	No	No	7	4
325	5x39	5x43	5ht_on	0	100	No	No	No	No	7	6
326	5x44	6x56	5ht_on	0	100	No	No	No	No	6	5
327	5x47	6x44	5ht_on	0	100	No	Yes	Yes	Yes	8	9
328	5x47	6x49	5ht_on	0	100	No	Yes	No	No	8	6
329	5x51	6x44	5ht_on	0	100	No	No	Yes	Yes	6	9
330	5x54	5x58	5ht_on	0	100	No	No	Yes	Yes	8	9
331	5x54	6x44	5ht_on	0	100	No	No	Yes	Yes	8	9
332	5x58	6x37	5ht_on	0	100	Yes	Yes	No	No	9	8
333	5x58	6x40	5ht_on	0	100	Yes	Yes	No	No	9	8
334	5x62	6x34	5ht_on	0	100	No	No	No	No	5	7
335	5x66	6x30	5ht_on	0	100	Yes	Yes	No	Yes	6	8
336	7x49	7x53	5ht_on	0	100	Yes	Yes	No	Yes	9	9
337	7x52	7x53	5ht_on	0	100	No	No	No	Yes	8	9
338	7x54	8x50	5ht_on	0	100	No	No	Yes	Yes	7	8
339	3x47	5x54	5ht_on	0	100	No	No	No	No	9	8
340	3x53	I2x53	5ht_on	0	100	No	No	Yes	Yes	8	7
341	3x54	5x61	5ht_on	0	100	No	No	No	No	9	9
342	4x41	4x45	5ht_on	0	100	No	No	No	No	6	6
343	5x39	E2	5ht_on	0	100	No	No	Yes	Yes	7	3
344	7x34	E3	5ht_on	0	100	Yes	Yes	Yes	Yes	3	3
345	5x37	6x59	5ht_on	0	100	No	No	No	No	4	5
346	3x30	4x58	5ht_on	0	100	No	No	No	No	6	0
347	5x461	Lig	5ht_on	0	75	No	No	Yes	Yes	6	0
348	2x42	4x42	5ht_on	0	63.3333	No	Yes	No	No	8	7
349	2x42	4x45	5ht_on	0	48.3333	No	Yes	No	No	8	6
350	5x62	6x37	5ht_on	0	58.3333	No	No	No	No	5	8
351	3x37	4x56	5ht_on	0	50	No	No	No	No	7	6
352	1x57	8x50	5ht_on	0	47.2222	No	No	Yes	Yes	7	8
353	2x62	2x66	5ht_on	0	53.3333	No	No	No	No	4	4
354	I2x52	I2x56	5ht_on	0	53.3333	No	No	No	No	5	4
355	1x60	I1x49	5ht_on	0	75	No	Yes	No	No	6	6
356	5x37	6x60	5ht_on	0	50	No	No	No	No	4	4
357	5x70	5x74	5ht_on	0	16.6667	No	No	No	No	0	0
358	4x58	4x62	5ht_on	0	48.3333	No	No	No	No	0	5
359	1x56	8x54	5ht_on	0	45.8333	No	No	No	No	7	6
360	7x30	7x33	5ht_on	0	40	No	No	No	No	4	4
361	1x60	8x53	5ht_on	0	58.3333	No	Yes	No	No	6	7
362	2x43	8x50	5ht_on	0	40	No	No	Yes	Yes	8	8
363	1x46	1x50	5ht_on	0	48.3333	No	No	No	Yes	7	9
364	2x39	3x49	5ht_on	0	33.3333	No	No	Yes	Yes	8	9
365	2x51	2x55	5ht_on	0	41.6667	No	No	No	No	7	4
366	6x45	6x49	5ht_on	0	58.3333	No	No	No	No	6	6
367	5x67	5x71	5ht_on	0	28.3333	No	No	No	No	5	0
368	5x40	6x59	5ht_on	0	40	No	No	No	No	6	5
369	3x44	5x50	5ht_on	0	45.8333	No	No	No	No	6	9
370	7x30	7x32	5ht_on	0	27.7778	No	No	No	No	4	1
371	E1x51	E1x52	5ht_on	0	40.5556	No	No	Yes	No	3	5
372	1x53	7x54	5ht_on	0	37.5	No	No	No	No	9	7
373	8x50	8x54	5ht_on	0	33.3333	Yes	Yes	No	No	8	6
374	2x48	2x52	5ht_on	0	25.8333	No	No	No	No	6	7
375	1x55	1x59	5ht_on	0	45	No	No	No	No	4	5
376	5x42	5x46	5ht_on	0	16.6667	No	No	No	No	4	4
377	5x69	6x30	5ht_on	0	30.5556	No	No	No	Yes	5	8
378	6x40	7x56	5ht_on	0	16.6667	No	No	No	Yes	8	7
379	6x39	7x56	5ht_on	0	36.6667	No	No	No	Yes	6	7
380	7x36	7x37	5ht_on	0	37.5	No	No	Yes	Yes	4	5
381	1x35	2x65	5ht_on	0	17.5	No	No	No	No	3	5
382	7x48	7x52	5ht_on	0	25	No	No	No	No	6	8
383	3x52	I2	5ht_on	0	16.6667	No	No	No	No	5	0
384	I2x54	I2x55	5ht_on	0	21.6667	No	No	No	No	6	4
385	2x57	2x58	5ht_on	0	0	Yes	Yes	No	No	8	8
386	3x55	5x64	5ht_on	0	20	No	No	No	No	6	6
387	4x64	E2	5ht_on	0	36.6667	No	No	Yes	Yes	4	3
388	1x42	7x47	5ht_on	0	25.5556	No	No	No	No	7	6
389	5x73	5x77	5ht_on	0	16.6667	No	No	No	No	0	0
390	8x61	8x62	5ht_on	0	16.6667	No	No	No	No	0	0
391	4x43	4x47	5ht_on	0	33.3333	No	No	No	No	4	2
392	5x52	5x56	5ht_on	0	33.3333	No	No	No	No	3	5
393	3x27	3x30	5ht_on	0	20	No	No	No	No	4	6
394	2x61	2x65	5ht_on	0	30.5556	No	No	No	No	6	5
395	5x67	5x70	5ht_on	0	20	No	No	No	No	5	0
396	7x28	7x32	5ht_on	0	16.6667	No	No	No	No	2	1
397	1x33	1x35	5ht_on	0	16.6667	No	No	No	No	5	3
398	8x49	8x52	5ht_on	0	16.6667	No	No	No	No	6	4
399	1x38	1x42	5ht_on	0	16.6667	No	No	No	No	4	7
400	6x57	6x61	5ht_on	0	13.0556	No	No	No	No	4	3
401	7x55	8x51	5ht_on	0	20	No	No	No	No	5	9
402	7x51	7x55	5ht_on	0	27.2222	No	No	No	No	6	5
403	4x51	4x55	5ht_on	0	16.6667	No	No	No	No	4	4
404	1x34	1x37	5ht_on	0	5.55556	No	No	No	No	4	4
405	5x65	6x33	5ht_on	0	0.833333	No	No	No	No	8	8
406	5x71	5x72	5ht_on	0	16.6667	No	No	No	No	0	0
407	7x27	E3	5ht_on	0	16.6667	No	No	Yes	Yes	3	3
408	4x48	4x52	5ht_on	0	11.6667	No	No	Yes	No	2	5
409	4x54	4x55	5ht_on	0	16.6667	No	No	No	No	4	4
410	2x41	4x43	5ht_on	0	16.6667	Yes	No	No	No	4	4
411	8x58	8x59	5ht_on	0	25	No	No	No	No	6	4
412	3x56	I2x50	5ht_on	0	0.833333	No	No	No	No	6	8
413	6x32	6x36	5ht_on	0	16.6667	No	No	No	No	8	8
414	I2x51	I2x55	5ht_on	0	21.6667	No	No	No	No	7	4
415	5x76	I3	5ht_on	0	16.6667	No	No	No	No	0	0
416	3x21	E1x50	5ht_on	0	0	No	No	Yes	Yes	7	7
417	5x70	6x30	5ht_on	0	16.6667	No	No	No	Yes	0	8
418	1x56	8x57	5ht_on	0	3.33333	No	No	Yes	No	7	4
419	5x68	5x71	5ht_on	0	14.1667	No	No	No	No	7	0
420	4x52	5x46	5ht_on	0	0	Yes	No	No	No	5	4
421	1x40	2x61	5ht_on	0	0	No	No	No	No	3	6
422	I2x54	I2x57	5ht_on	0	16.6667	No	No	No	No	6	6
423	1x32	1x34	5ht_on	0	16.6667	No	No	No	No	6	4
424	6x47	7x40	5ht_on	0	16.6667	No	No	No	No	8	7
425	5x74	5x75	5ht_on	0	16.6667	No	No	No	No	0	0
426	1x58	1x59	5ht_on	0	4.16667	No	No	No	No	1	5
427	6x28	6x31	5ht_on	0	5.55556	No	No	Yes	No	6	5
428	5x74	5x77	5ht_on	0	16.6667	No	No	No	No	0	0
429	6x31	6x35	5ht_on	0	3.33333	Yes	No	No	No	5	7
430	6x27	6x30	5ht_on	0	10.5556	No	No	No	Yes	5	8
431	5x65	5x66	5ht_on	0	16.6667	No	No	Yes	Yes	8	6
432	8x56	8x60	5ht_on	0	16.6667	No	No	No	No	4	8
433	2x63	E1	5ht_on	0	16.6667	No	No	No	No	5	3
434	5x63	5x66	5ht_on	0	4.16667	No	No	Yes	Yes	4	6
435	1x28	1x31	5ht_on	0	3.33333	No	No	No	No	3	3
436	6x46	6x47	5ht_on	0	4.16667	No	No	No	No	5	8
437	6x24	6x26	5ht_on	0	8.33333	No	No	No	No	0	5
438	2x67	2x68	5ht_on	0	0	No	No	No	No	5	0
439	8x55	8x59	5ht_on	0	8.33333	No	No	No	No	3	4
440	6x26	6x27	5ht_on	0	9.72222	No	No	No	No	5	5
441	5x78	5x79	5ht_on	0	0	No	No	No	No	0	0
442	5x73	I3	5ht_on	0	3.33333	No	No	No	No	0	0
443	6x20	6x23	5ht_on	0	3.33333	No	No	No	No	0	0
444	1x28	1x30	5ht_on	0	3.33333	No	No	No	No	3	1
445	1x29	NT	5ht_on	0	3.33333	No	No	Yes	No	3	0
446	6x19	6x23	5ht_on	0	3.33333	No	No	No	No	0	0
447	1x31	1x32	5ht_on	0	0.833333	No	No	No	No	3	6
448	6x18	6x22	5ht_on	0	0.833333	No	No	No	No	0	0
449	6x14	6x15	5ht_on	0	0.833333	No	No	No	No	0	0
450	6x15	6x18	5ht_on	0	0.833333	No	No	No	No	0	0
451	6x15	6x16	5ht_on	0	0	No	No	No	No	0	0
452	6x16	6x20	5ht_on	0	0.833333	No	No	No	No	0	0
453	6x22	6x25	5ht_on	0	0	No	No	No	No	0	5
454	6x16	6x17	5ht_on	0	0	No	No	No	No	0	0
455	6x17	6x20	5ht_on	0	0	No	No	No	No	0	0
456	6x21	6x24	5ht_on	0	0	No	No	No	No	0	0

Orange: nodes, hubs and links specific of 5ht_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	5ht_off Avg Int. Strength	5ht_on Avg Int. Strength	5ht_off Num Of Links	5ht_on Num Of Links	ConSurf
1	1x49	5ht_off	33.3333	0	4	2	8
2	I1x50	5ht_off	22.2222	10	4	3	8
3	2x41	5ht_off	0	11.1111	4	3	4
4	2x60	5ht_off	0	0	4	2	7
5	E1x52	5ht_off	0	0	4	3	5
6	3x50	5ht_off	33.3333	0	4	2	9
7	4x38	5ht_off	0	11.1111	5	3	7
8	4x52	5ht_off	0	0	4	3	5
9	4x57	5ht_off	0	0	4	3	7
10	5x36	5ht_off	0	0	6	2	5
11	6x31	5ht_off	0	0	4	2	5
12	6x41	5ht_off	29.6296	0	4	2	8
13	6x55	5ht_off	0	16.6667	4	2	7
14	6x58	5ht_off	0	16.6667	4	2	4
15	7x45	5ht_off	33.3333	16.6667	4	3	9
16	8x57	5ht_off	18.5185	0	4	2	4
17	CT	5ht_off	12.963	0	5	1	5
18	NT	5ht_off	44.4444	0	8	1	0
19	2x50	Shared	88.8889	74.1667	5	5	9
20	2x57	Shared	100	0	5	4	8
21	E1x50	Shared	100	71.6667	6	7	7
22	3x42	Shared	88.8889	50	4	4	8
23	3x49	Shared	66.6667	0	5	4	9
24	3x51	Shared	33.3333	49.4444	5	4	8
25	I2x53	Shared	33.3333	46.6667	5	4	7
26	4x50	Shared	55.5556	0	4	4	9
27	E2	Shared	100	98.3333	13	12	3
28	5x48	Shared	33.3333	5.83333	4	4	5
29	5x58	Shared	0	50	4	6	9
30	5x66	Shared	0	0	4	4	6
31	6x44	Shared	98.1482	30	5	4	9
32	6x48	Shared	100	100	7	6	8
33	6x51	Shared	100	24.1667	6	4	7
34	6x52	Shared	98.1482	89.1667	5	5	7
35	E3	Shared	33.3333	16.6667	5	4	3
36	7x34	Shared	0	16.6667	4	4	3
37	7x37	Shared	33.3333	6.66667	4	4	5
38	7x39	Shared	94.4445	55	7	4	6
39	7x42	Shared	100	100	7	5	7
40	7x49	Shared	38.8889	40.8333	4	5	9
41	8x50	Shared	33.3333	91.6667	4	7	8
42	Lig	Shared	100	100	13	9	0
43	1x50	5ht_on	0	8.33333	3	4	9
44	1x60	5ht_on	5.55556	8.33333	3	4	6
45	2x42	5ht_on	33.3333	25	3	4	8
46	2x46	5ht_on	0	26.6667	3	4	9
47	5x47	5ht_on	33.3333	81.9444	3	5	8
48	6x30	5ht_on	0	0	1	4	8
49	7x53	5ht_on	0	78.3333	2	5	9
50	7x56	5ht_on	0	0	3	4	7

Orange: nodes, hubs and links specific of 5ht_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht_off Recurrence	5ht_on Recurrence	5ht_off Hub1?	5ht_on Hub1?	5ht_off Hub2?	5ht_on Hub2?	ConSurf1	ConSurf2
1	1x46	2x57	5ht_off	28.8385	0	No	No	Yes	Yes	7	8
2	1x46	2x54	5ht_off	19.1756	0	No	No	No	No	7	6
3	2x56	7x42	5ht_off	39.751	0.118779	No	No	Yes	Yes	8	7
4	2x53	2x56	5ht_off	40.371	0	No	No	No	No	7	8
5	1x50	7x50	5ht_off	41.0685	3.88012	No	Yes	No	No	9	9
6	1x49	7x50	5ht_off	39.8818	2.59183	Yes	No	No	No	8	9
7	1x49	7x54	5ht_off	36.254	0	Yes	No	No	No	8	7
8	7x54	8x54	5ht_off	34.9123	0	No	No	No	No	7	6
9	1x52	8x54	5ht_off	33.9097	1.28221	No	No	No	No	6	6
10	1x52	1x56	5ht_off	28.3542	0	No	No	No	No	6	7
11	1x56	8x50	5ht_off	26.9641	0	No	No	Yes	Yes	7	8
12	8x50	I1x50	5ht_off	20.0475	7.88816	Yes	Yes	Yes	No	8	8
13	2x46	2x50	5ht_off	28.514	2.8172	No	Yes	Yes	Yes	9	9
14	2x45	3x42	5ht_off	63.3391	2.76238	No	No	Yes	Yes	9	8
15	2x45	4x46	5ht_off	62.2397	1.39185	No	No	No	No	9	8
16	2x41	4x46	5ht_off	11.3823	0	Yes	No	No	No	4	8
17	7x42	Lig	5ht_off	77.4048	0	Yes	Yes	Yes	Yes	7	0
18	6x48	Lig	5ht_off	63.4602	0	Yes	Yes	Yes	Yes	8	0
19	2x42	4x46	5ht_off	50.8331	0	No	Yes	No	No	8	8
20	1x47	2x54	5ht_off	17.0832	2.46086	No	No	No	No	5	6
21	1x47	2x55	5ht_off	10.7478	0	No	No	No	No	5	4
22	2x63	E1x50	5ht_off	30.8098	4.28824	No	No	Yes	Yes	5	7
23	E1x50	E1x52	5ht_off	40.0029	4.91259	Yes	Yes	Yes	No	7	5
24	3x25	E1x50	5ht_off	30.7033	2.45782	No	No	Yes	Yes	9	7
25	2x63	E2	5ht_off	29.0904	0	No	No	Yes	Yes	5	3
26	3x25	E2	5ht_off	29.0904	0	No	No	Yes	Yes	9	3
27	3x40	6x44	5ht_off	55.4054	0	No	No	Yes	Yes	8	9
28	3x40	5x50	5ht_off	54.243	0	No	No	No	No	8	9
29	3x41	5x50	5ht_off	51.889	5.53999	No	No	No	No	6	9
30	3x41	3x44	5ht_off	43.345	0	No	No	No	No	6	6
31	3x44	5x54	5ht_off	40.8166	0	No	No	No	No	6	8
32	5x54	6x41	5ht_off	39.5379	0	No	No	Yes	No	8	8
33	3x49	I2x53	5ht_off	30.4756	6.27703	Yes	Yes	Yes	Yes	9	7
34	3x52	I2x53	5ht_off	24.7554	3.67607	No	No	Yes	Yes	5	7
35	3x51	3x52	5ht_off	20.9774	0	Yes	Yes	No	No	8	5
36	5x58	6x41	5ht_off	30.1269	3.41719	Yes	Yes	Yes	No	9	8
37	5x58	5x62	5ht_off	24.6004	0	Yes	Yes	No	No	9	5
38	5x36	E2	5ht_off	23.9707	3.31668	Yes	No	Yes	Yes	5	3
39	5x36	5x39	5ht_off	10.7333	0	Yes	No	No	No	5	7
40	5x44	5x48	5ht_off	12.7337	1.77864	No	No	Yes	Yes	6	5
41	5x45	5x48	5ht_off	12.4867	2.11366	No	No	Yes	Yes	4	5
42	6x40	7x49	5ht_off	11.8909	0	No	No	Yes	Yes	8	9
43	6x40	7x52	5ht_off	10.4379	0	No	No	No	No	8	8
44	6x51	Lig	5ht_off	10.9077	2.36645	Yes	Yes	Yes	Yes	7	0
45	6x54	7x34	5ht_off	26.3731	9.99574	No	No	Yes	Yes	5	3
46	6x54	7x37	5ht_off	23.8158	8.92977	No	No	Yes	Yes	5	5
47	6x55	Lig	5ht_off	12.4528	9.66681	Yes	No	Yes	Yes	7	0
48	6x55	7x34	5ht_off	10.6074	0	Yes	No	Yes	Yes	7	3
49	6x58	7x34	5ht_off	15.1797	0.794908	Yes	No	Yes	Yes	4	3
50	7x33	7x37	5ht_off	10.8883	5.69836	No	No	Yes	Yes	4	5
51	5x66	6x31	5ht_off	12.8693	0	Yes	Yes	Yes	No	6	5
52	2x67	NT	5ht_off	26.1164	0	No	No	Yes	No	5	0
53	2x66	2x67	5ht_off	27.9328	2.8903	No	No	No	No	4	5
54	2x66	E1x51	5ht_off	29.7007	0	No	No	No	No	4	3
55	2x62	E1x51	5ht_off	31.4976	0	No	No	No	No	4	3
56	2x62	E1x52	5ht_off	33.1977	0	No	No	Yes	No	4	5
57	3x49	4x38	5ht_off	10.7914	0	Yes	Yes	Yes	No	9	7
58	1x60	I1x50	5ht_off	10.6074	6.66687	No	Yes	Yes	No	6	8
59	2x60	7x42	5ht_off	93.592	0	Yes	No	Yes	Yes	7	7
60	6x44	7x45	5ht_off	22.5225	0	Yes	Yes	Yes	No	9	9
61	6x48	6x51	5ht_off	14.5452	0	Yes	Yes	Yes	Yes	8	7
62	2x53	7x46	Shared	39.3781	35.7708	No	No	No	No	7	9
63	2x50	7x46	Shared	39.0003	36.8825	Yes	Yes	No	No	9	9
64	1x50	2x50	Shared	46.8565	18.8646	No	Yes	Yes	Yes	9	9
65	2x46	3x42	Shared	72.0043	22.7508	No	Yes	Yes	Yes	9	8
66	6x48	7x45	Shared	53.066	100	Yes	Yes	Yes	No	8	9
67	7x45	7x49	Shared	74.4503	97.3077	Yes	No	Yes	Yes	9	9
68	2x46	7x49	Shared	45.079	19.5742	No	Yes	Yes	Yes	9	9
69	2x60	3x28	Shared	100	24.8767	Yes	No	No	No	7	5
70	3x28	E1x50	Shared	97.709	20.695	No	No	Yes	Yes	5	7
71	6x44	6x48	Shared	35.5468	67.8595	Yes	Yes	Yes	Yes	9	8
72	2x42	3x49	Shared	47.2876	13.821	No	Yes	Yes	Yes	8	9
73	5x62	5x66	Shared	23.1958	29.7009	No	No	Yes	Yes	5	6
74	6x51	7x34	Shared	32.2096	15.4048	Yes	Yes	Yes	Yes	7	3
75	2x57	7x42	Shared	36.903	12.2556	Yes	Yes	Yes	Yes	8	7
76	2x50	7x49	Shared	23.8739	52.0284	Yes	Yes	Yes	Yes	9	9
77	6x48	6x52	Shared	10.2054	75.6898	Yes	Yes	Yes	Yes	8	7
78	1x39	7x39	5ht_on	1.30776	33.6876	No	No	Yes	Yes	6	6
79	7x39	7x42	5ht_on	6.41771	67.5489	Yes	Yes	Yes	Yes	6	7
80	3x32	7x42	5ht_on	0.484355	51.3523	No	No	Yes	Yes	8	7
81	3x32	Lig	5ht_on	2.23772	54.0933	No	No	Yes	Yes	8	0
82	3x36	Lig	5ht_on	0.833091	43.4793	No	No	Yes	Yes	7	0
83	3x36	6x48	5ht_on	0.837935	43.7991	No	No	Yes	Yes	7	8
84	6x52	Lig	5ht_on	2.99332	62.6272	Yes	Yes	Yes	Yes	7	0
85	7x38	7x42	5ht_on	9.5079	29.6309	No	No	Yes	Yes	6	7
86	6x51	7x38	5ht_on	9.62898	30.505	Yes	Yes	No	No	7	6
87	6x51	6x52	5ht_on	1.70493	40.8601	Yes	Yes	Yes	Yes	7	7
88	2x53	3x35	5ht_on	0	34.6531	No	No	No	No	7	7
89	2x52	3x35	5ht_on	2.16507	33.5293	No	No	No	No	7	7
90	2x48	2x52	5ht_on	0	32.3993	No	No	No	No	6	7
91	1x54	2x48	5ht_on	1.52088	31.2633	No	No	No	No	6	6
92	1x54	2x47	5ht_on	3.03691	30.1212	No	No	No	No	6	9
93	1x53	2x47	5ht_on	1.52088	28.973	No	No	No	No	9	9
94	1x53	7x54	5ht_on	0	27.8187	No	No	No	No	9	7
95	7x54	8x50	5ht_on	0	26.6583	No	No	Yes	Yes	7	8
96	7x49	7x53	5ht_on	0	37.0957	Yes	Yes	No	Yes	9	9
97	3x46	7x53	5ht_on	0	32.1283	No	No	No	Yes	9	9
98	2x42	3x46	5ht_on	1.94711	31.2694	No	Yes	No	No	8	9
99	2x60	7x39	5ht_on	8.55371	26.6614	Yes	No	Yes	Yes	7	6
100	5x43	Lig	5ht_on	1.54025	30.377	No	No	Yes	Yes	6	0
101	5x39	5x43	5ht_on	0	28.8421	No	No	No	No	7	6
102	5x39	E2	5ht_on	0	24.2005	No	No	Yes	Yes	7	3
103	3x33	Lig	5ht_on	9.71617	17.954	No	No	Yes	Yes	6	0
104	3x33	4x57	5ht_on	8.2292	16.352	No	No	Yes	No	6	7
105	3x42	4x49	5ht_on	2.00523	14.8748	Yes	Yes	No	No	8	6
106	3x41	4x49	5ht_on	0	13.5408	No	No	No	No	6	6
107	5x54	6x44	5ht_on	0	92.6479	No	No	Yes	Yes	8	9
108	3x47	5x54	5ht_on	0	20.6828	No	No	No	No	9	8
109	5x47	6x52	5ht_on	8.20498	32.1709	No	Yes	Yes	Yes	8	7
110	5x47	6x44	5ht_on	0	30.2887	No	Yes	Yes	Yes	8	9
111	5x54	5x58	5ht_on	0	70.6676	No	No	Yes	Yes	8	9
112	3x47	5x57	5ht_on	2.00523	21.3437	No	No	No	No	9	5
113	3x51	5x57	5ht_on	3.40986	19.7021	Yes	Yes	No	No	8	5
114	5x58	6x37	5ht_on	0	34.4704	Yes	Yes	No	No	9	8
115	5x58	6x40	5ht_on	0	35.5424	Yes	Yes	No	No	9	8
116	5x62	6x37	5ht_on	0	32.8562	No	No	No	No	5	8
117	6x40	7x56	5ht_on	0	33.9739	No	No	No	Yes	8	7
118	6x36	7x56	5ht_on	1.51119	16.4738	No	No	No	Yes	8	7
119	5x66	6x30	5ht_on	0	21.627	Yes	Yes	No	Yes	6	8
120	5x70	6x30	5ht_on	0	14.0495	No	No	No	Yes	0	8
121	7x55	7x56	5ht_on	1.51603	10.8424	No	No	No	Yes	5	7
122	2x61	2x65	5ht_on	0	24.7914	No	No	No	No	6	5
123	1x39	2x61	5ht_on	0	31.9455	No	No	No	No	6	6
124	1x35	2x65	5ht_on	0	20.5945	No	No	No	No	3	5
125	1x32	1x35	5ht_on	5.77836	15.755	No	No	No	No	6	3
126	6x32	6x36	5ht_on	0	14.8444	No	No	No	No	8	8
127	6x29	6x32	5ht_on	3.76344	13.1662	No	No	No	No	6	8
128	6x25	6x29	5ht_on	1.10433	11.9693	No	No	No	No	5	6
129	6x22	6x25	5ht_on	0	10.7724	No	No	No	No	0	5

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	10.1426	8.50972	1	1	2	1
2x56	7x42	Shared	4.60556	3.90025	1	1	2	1
2x57	7x39	5ht_off	5.40685	0	1	0	2	2
2x57	7x42	Shared	5.01018	5.70719	1	0	2	1
2x60	7x39	Shared	7.49389	3.05756	1	0	2	2
2x60	7x42	5ht_off	4.71444	0	1	0	2	1
3x29	E2x52	Shared	3.58185	4.27364	0	0	2	1
3x32	7x42	Shared	9.17482	9.20428	1	1	1	1
3x32	Lig	Shared	14.4174	11.3949	1	1	1	0
3x33	4x57	Shared	4.3713	4.05761	0	0	1	2
3x33	Lig	Shared	5.88167	11.4948	0	0	1	0
3x36	6x48	Shared	3.80204	5.12467	1	0	1	1
3x36	Lig	Shared	6.52167	9.8132	1	0	1	0
3x37	4x53	Shared	5.51111	4.75589	0	0	1	2
3x37	5x461	Shared	4.97389	3.88683	0	0	1	1
3x37	Lig	5ht_off	4.08944	0	0	0	1	0
3x40	6x44	5ht_off	7.90722	0	0	0	2	2
E2x52	Lig	Shared	5.64537	3.62419	0	0	1	0
5x43	Lig	Shared	6.47389	4.60272	0	0	1	0
5x44	5x48	Shared	4.40333	3.58386	1	1	1	2
5x44	6x52	Shared	4.2313	4.87089	1	1	1	1
5x44	Lig	5ht_off	3.57574	0	1	1	1	0
5x47	5x48	Shared	8.65759	6.07303	0	1	2	2
5x47	6x52	Shared	26.852	20.8456	0	1	2	1
5x48	6x56	Shared	4.99944	4.96325	0	1	2	2
6x44	6x48	Shared	4.41741	5.03608	1	1	2	1
6x44	7x45	5ht_off	5.86518	0	1	1	2	2
6x48	6x51	5ht_off	7.44463	0	1	0	1	1
6x48	6x52	Shared	6.51407	5.40839	1	0	1	1
6x48	7x41	Shared	12.1217	6.99875	1	0	1	2
6x48	7x45	Shared	4.27815	10.2021	1	0	1	2
6x48	Lig	5ht_off	9.35315	0	1	0	1	0
6x51	6x52	Shared	9.62778	3.49669	1	1	1	1
6x51	6x55	5ht_off	7.01278	0	1	1	1	1
6x51	7x34	Shared	4.12519	3.19081	1	1	1	2
6x51	7x38	Shared	6.2487	5.13111	1	1	1	1
6x51	Lig	Shared	12.058	8.92347	1	1	1	0
6x52	Lig	Shared	11.1139	8.59681	1	1	1	0
6x55	7x34	5ht_off	3.86759	0	1	0	1	2
6x55	Lig	Shared	5.13759	6.44811	1	0	1	0
7x38	7x42	Shared	9.33315	8.02386	1	0	1	1
7x38	Lig	5ht_off	6.78574	0	1	0	1	0
7x39	7x42	Shared	8.59148	7.03947	1	0	2	1
7x42	Lig	5ht_off	3.94444	0	1	1	1	0
5x40	6x55	Shared	1.50907	1.92958	0	0	2	1
3x40	6x48	5ht_on	0	6.09014	0	0	2	1
5x39	5x43	5ht_on	0	6.04161	0	3	2	1
5x44	6x56	5ht_on	0	3.52053	1	1	1	2
5x47	6x44	5ht_on	0	4.30594	0	1	2	2
5x461	Lig	5ht_on	0	3.1565	0	0	1	0
3x37	4x56	5ht_on	0	3.09889	0	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	5ht_off	5ht2_off 5ht5_off 5ht1_off
	5ht_on	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on

Network Difference
Value	5ht_off	5ht_on
I_min	3.52741	3.17156
Number of Linked Nodes	277	299
Number of Specific Nodes	2 (0.72%)	24 (8.03%)
Number of Shared Nodes	275 (99.28%)	275 (91.97%)
Number of Links	308	317
Number of Specific Links	139 (45.13%)	148 (46.69%)
Number of Shared Links	169 (54.87%)	169 (53.31%)
Number of Hubs	42	32
Number of Specific Hubs	18 (42.86%)	8 (25.00%)
Number of Shared Hubs	24 (57.14%)	24 (75.00%)
Average % Shared Neighbours (Jaccard)	40.47
Average % Shared Neighbours (Otsuka)	48.82
Average % Shared Neighbours (Overlap Coefficient)	57.05
Average % Shared Cliques (k3-6)	55.15
Graphlets Similarity	0.613939

Paths Difference
Value	5ht_off	5ht_on
Number Of Nodes in MetaPath	73	66
Specific Nodes in MetaPath	41 (56.16%)	34 (51.52%)
Shared Nodes in MetaPath	275 (99.28%)	275 (99.28%)
Number Of Links MetaPath	77	68
Specific Links in MetaPath	61 (79.22%)	52 (76.47%)
Shared Links in MetaPath	169 (54.87%)	169 (54.87%)
Number of Shortest Paths	52378	71702
Length Of Smallest Path	3	3
Average Path Length	14.2392	14.6783
Length of Longest Path	32	35
Minimum Path Strength	0.276481	0.309381
Average Path Strength	5.33098	5.07796
Maximum Path Strength	18.983	14.7212
Minimum Path Correlation	0.70037	0.700333
Average Path Correlation	0.907178	0.9012
Maximum Path Correlation	0.986481	0.985028
Minimum % Of Corr. Nodes	3.33333	3.33333
Average % Of Corr. Nodes	41.4379	36.6314
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	46.2231	42.8215
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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