psnGPCR

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Orange: nodes, hubs and links specific of adrenergic_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of adrenergic_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	adrenergic_off Int. Strength	adrenergic_on Int. Strength	adrenergic_off Hub1?	adrenergic_on Hub1?	adrenergic_off Hub2?	adrenergic_on Hub2?	ConSurf1	ConSurf2
1	1x46	7x46	adrenergic_off	100	0	No	No	No	No	7	9
2	1x53	7x53	adrenergic_off	100	0	No	No	Yes	Yes	9	9
3	1x60	I1x49	adrenergic_off	100	0	Yes	Yes	No	No	6	5
4	2x39	3x50	adrenergic_off	100	0	No	No	Yes	No	8	9
5	2x42	3x46	adrenergic_off	100	0	Yes	Yes	No	No	8	9
6	2x43	7x53	adrenergic_off	100	0	No	No	Yes	Yes	7	9
7	2x53	2x56	adrenergic_off	100	0	No	No	No	No	8	7
8	2x59	3x24	adrenergic_off	100	0	No	No	No	No	4	4
9	2x62	E1x52	adrenergic_off	100	0	No	No	Yes	Yes	4	5
10	E1x49	E1x51	adrenergic_off	100	0	No	No	No	No	3	4
11	3x26	4x64	adrenergic_off	100	0	No	No	No	No	6	5
12	3x28	Lig	adrenergic_off	100	0	Yes	Yes	Yes	Yes	6	0
13	3x29	E2x52	adrenergic_off	100	0	No	No	No	No	6	4
14	3x34	4x50	adrenergic_off	100	0	No	No	Yes	No	5	9
15	3x37	4x57	adrenergic_off	100	0	Yes	No	No	No	6	7
16	3x38	4x53	adrenergic_off	100	0	No	No	No	No	7	8
17	3x39	6x44	adrenergic_off	100	0	No	No	Yes	Yes	9	9
18	3x41	4x53	adrenergic_off	100	0	Yes	No	No	No	6	8
19	3x43	6x44	adrenergic_off	100	0	No	No	Yes	Yes	8	9
20	3x47	5x57	adrenergic_off	100	0	No	No	No	No	8	6
21	3x49	3x50	adrenergic_off	100	0	Yes	Yes	Yes	No	9	9
22	3x50	6x34	adrenergic_off	100	0	Yes	No	No	No	9	7
23	3x55	3x56	adrenergic_off	100	0	No	No	No	No	7	6
24	4x41	I2x56	adrenergic_off	100	0	No	No	No	No	7	5
25	E2	Lig	adrenergic_off	100	0	Yes	Yes	Yes	Yes	3	0
26	5x48	6x56	adrenergic_off	100	0	No	No	No	No	5	5
27	5x51	6x45	adrenergic_off	100	0	No	No	No	No	6	5
28	5x54	6x41	adrenergic_off	100	0	No	No	Yes	No	8	8
29	6x35	7x55	adrenergic_off	100	0	No	No	No	No	7	7
30	6x36	7x55	adrenergic_off	100	0	No	No	No	No	8	7
31	6x40	7x49	adrenergic_off	100	0	No	No	No	Yes	8	9
32	6x40	7x52	adrenergic_off	100	0	No	No	No	No	8	8
33	6x40	7x53	adrenergic_off	100	0	No	No	Yes	Yes	8	9
34	6x44	7x45	adrenergic_off	100	0	Yes	Yes	No	No	9	9
35	6x48	6x51	adrenergic_off	100	0	Yes	Yes	Yes	Yes	8	7
36	6x54	E3	adrenergic_off	100	0	No	No	Yes	Yes	4	4
37	7x49	7x53	adrenergic_off	100	0	No	Yes	Yes	Yes	9	9
38	7x53	8x50	adrenergic_off	100	0	Yes	Yes	Yes	Yes	9	8
39	8x48	8x51	adrenergic_off	100	0	No	No	No	No	6	8
40	6x29	6x30	adrenergic_off	100	0	No	No	No	No	6	7
41	I2x50	I2x51	adrenergic_off	100	0	No	No	No	No	8	6
42	I2x52	I2x53	adrenergic_off	100	0	No	Yes	Yes	Yes	5	7
43	6x30	I2x53	adrenergic_off	100	0	No	No	Yes	Yes	7	7
44	6x26	6x35	adrenergic_off	100	0	No	No	No	No	0	7
45	7x31	7x35	adrenergic_off	100	0	No	No	No	No	3	4
46	Lig	Lig	adrenergic_off	100	0	Yes	Yes	Yes	Yes	0	0
47	2x39	I2x57	adrenergic_off	100	0	No	No	Yes	No	8	6
48	3x43	6x41	adrenergic_off	60.7143	0	No	No	Yes	No	8	8
49	6x54	7x34	adrenergic_off	53.5714	0	No	No	No	No	4	4
50	5x65	6x31	adrenergic_off	50	0	No	No	Yes	No	8	5
51	3x24	3x27	adrenergic_off	62.5	0	No	No	No	No	4	4
52	2x41	4x43	adrenergic_off	50	0	No	No	No	No	5	4
53	6x28	6x31	adrenergic_off	62.5	0	No	No	Yes	No	0	5
54	3x50	6x37	adrenergic_off	50	0	Yes	No	No	No	9	8
55	3x51	5x61	adrenergic_off	62.5	0	No	Yes	No	No	8	9
56	2x40	2x43	adrenergic_off	53.5714	0	No	Yes	No	No	9	7
57	4x39	I1x48	adrenergic_off	50	0	No	No	No	No	3	6
58	5x58	6x38	adrenergic_off	57.1429	0	Yes	Yes	No	No	9	5
59	3x48	5x57	adrenergic_off	50	0	No	No	No	No	6	6
60	2x66	E1x51	adrenergic_off	50	0	No	No	No	No	4	4
61	5x58	5x62	adrenergic_off	62.5	0	Yes	Yes	No	Yes	9	6
62	5x68	6x27	adrenergic_off	50	0	No	No	No	No	7	0
63	5x37	6x59	adrenergic_off	50	0	No	No	No	No	5	5
64	5x41	6x59	adrenergic_off	50	0	No	No	No	No	5	5
65	E2	NT	adrenergic_off	50	0	Yes	Yes	No	No	3	0
66	5x68	I2x52	adrenergic_off	50	0	No	No	No	Yes	7	5
67	5x64	5x68	adrenergic_off	25	0	No	No	No	No	6	7
68	3x23	3x27	adrenergic_off	32.1429	0	No	No	No	No	2	4
69	3x50	6x33	adrenergic_off	50	0	Yes	No	No	No	9	8
70	1x42	7x43	adrenergic_off	26.7857	0	No	No	No	No	6	4
71	2x51	2x55	adrenergic_off	56.25	0	No	No	No	No	7	5
72	2x38	4x42	adrenergic_off	19.6429	0	No	No	No	No	6	7
73	3x49	I2x55	adrenergic_off	50	0	Yes	Yes	No	No	9	5
74	5x69	6x31	adrenergic_off	50	0	No	Yes	Yes	No	5	5
75	3x44	5x54	adrenergic_off	12.5	0	No	No	No	No	6	8
76	6x29	6x32	adrenergic_off	25	0	No	No	No	No	6	8
77	I2x54	I2x57	adrenergic_off	50	0	No	No	Yes	No	5	6
78	5x45	5x49	adrenergic_off	12.5	0	No	No	No	No	4	5
79	4x40	4x43	adrenergic_off	39.2857	0	No	No	No	No	5	4
80	5x58	I3	adrenergic_off	25	0	Yes	Yes	Yes	No	9	0
81	6x47	7x40	adrenergic_off	0	0	No	No	No	No	8	7
82	8x58	CT	adrenergic_off	37.5	0	No	No	No	No	6	0
83	6x25	6x26	adrenergic_off	37.5	0	No	No	No	No	0	0
84	5x76	I3	adrenergic_off	25	0	No	No	Yes	No	0	0
85	5x71	I3	adrenergic_off	25	0	No	No	Yes	No	0	0
86	5x72	I3	adrenergic_off	25	0	No	No	Yes	No	0	0
87	6x58	6x62	adrenergic_off	25	0	No	No	No	No	4	0
88	1x34	NT	adrenergic_off	25	0	No	No	No	No	4	0
89	4x43	4x47	adrenergic_off	12.5	0	No	No	No	No	4	4
90	1x30	1x33	adrenergic_off	12.5	0	No	No	No	No	2	5
91	1x33	1x37	adrenergic_off	0	0	No	No	No	No	5	4
92	4x60	5x42	adrenergic_off	25	0	No	No	No	No	7	4
93	1x28	1x30	adrenergic_off	14.2857	0	No	No	No	No	0	2
94	5x72	6x24	adrenergic_off	12.5	0	No	No	No	No	0	0
95	4x44	4x48	adrenergic_off	0	0	No	No	No	No	3	3
96	8x56	8x60	adrenergic_off	12.5	0	No	No	No	No	4	7
97	1x41	1x45	adrenergic_off	0	0	No	No	No	No	4	5
98	5x70	I3	adrenergic_off	12.5	0	No	No	Yes	No	0	0
99	5x74	I3	adrenergic_off	12.5	0	No	No	Yes	No	0	0
100	1x27	1x31	adrenergic_off	3.57143	0	No	No	No	Yes	0	3
101	1x58	1x59	adrenergic_off	0	0	No	No	No	No	2	5
102	6x43	6x46	adrenergic_off	0	0	No	No	No	No	6	5
103	5x70	5x75	adrenergic_off	6.25	0	No	No	No	No	0	0
104	5x70	5x73	adrenergic_off	6.25	0	No	No	No	No	0	0
105	1x29	1x33	adrenergic_off	0	0	No	No	No	No	0	5
106	1x31	1x35	Shared	100	25	No	Yes	No	No	3	4
107	1x39	2x61	Shared	100	100	No	No	No	No	6	6
108	1x39	7x39	Shared	100	100	No	No	Yes	Yes	6	6
109	1x49	7x50	Shared	100	62.5	No	No	No	No	8	9
110	1x50	2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
111	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
112	1x51	2x51	Shared	100	50	No	No	No	No	3	7
113	1x52	8x54	Shared	100	100	No	No	Yes	Yes	6	7
114	1x57	2x44	Shared	100	100	No	No	No	No	7	5
115	1x60	I1x50	Shared	100	100	Yes	Yes	No	No	6	8
116	8x49	I1x49	Shared	100	100	No	No	No	No	6	5
117	8x50	I1x50	Shared	100	100	Yes	Yes	No	No	8	8
118	2x37	2x40	Shared	100	100	No	No	No	Yes	7	9
119	2x39	3x49	Shared	100	100	No	No	Yes	Yes	8	9
120	2x41	4x39	Shared	100	75	No	No	No	No	5	3
121	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	5
122	2x42	4x46	Shared	100	54.1667	Yes	Yes	No	No	8	7
123	2x45	3x42	Shared	100	100	No	No	No	No	9	8
124	2x45	4x46	Shared	100	100	No	No	No	No	9	7
125	2x45	4x50	Shared	100	100	No	No	Yes	No	9	9
126	2x46	3x43	Shared	100	100	No	Yes	No	No	9	8
127	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
128	2x50	7x49	Shared	100	100	No	Yes	No	Yes	9	9
129	2x52	3x35	Shared	100	100	No	No	No	No	6	6
130	2x53	3x35	Shared	100	100	No	No	No	No	8	6
131	2x53	7x46	Shared	100	100	No	No	No	No	8	9
132	2x56	3x32	Shared	100	100	No	No	No	No	7	7
133	2x56	7x42	Shared	100	100	No	No	Yes	Yes	7	7
134	2x57	7x42	Shared	100	100	No	No	Yes	Yes	7	7
135	2x59	E1x52	Shared	100	100	No	No	Yes	Yes	4	5
136	2x59	3x28	Shared	100	100	No	No	Yes	Yes	4	6
137	2x60	3x28	Shared	100	100	No	No	Yes	Yes	6	6
138	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	5	7
139	2x64	7x35	Shared	100	100	No	No	No	No	5	4
140	2x64	7x39	Shared	100	100	No	No	Yes	Yes	5	6
141	E1x49	E2	Shared	100	56.25	No	No	Yes	Yes	3	3
142	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	7	5
143	3x28	E1x50	Shared	100	100	Yes	Yes	Yes	Yes	6	7
144	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	7	9
145	E1x51	E1x52	Shared	100	52.0833	No	No	Yes	Yes	4	5
146	3x22	E2	Shared	100	100	No	No	Yes	Yes	4	3
147	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
148	3x26	E2	Shared	100	56.25	No	No	Yes	Yes	6	3
149	3x30	4x58	Shared	100	100	No	No	No	No	6	5
150	3x30	4x61	Shared	100	100	No	No	No	No	6	6
151	3x32	7x42	Shared	100	100	No	No	Yes	Yes	7	7
152	3x32	Lig	Shared	100	100	No	No	Yes	Yes	7	0
153	3x33	4x57	Shared	100	100	No	No	No	No	6	7
154	3x33	Lig	Shared	100	100	No	No	Yes	Yes	6	0
155	3x36	6x48	Shared	100	100	No	No	Yes	Yes	6	8
156	3x36	Lig	Shared	100	100	No	No	Yes	Yes	6	0
157	3x37	4x53	Shared	100	100	Yes	No	No	No	6	8
158	3x37	5x461	Shared	100	100	Yes	No	No	No	6	6
159	3x38	4x50	Shared	100	100	No	No	Yes	No	7	9
160	3x40	5x50	Shared	100	66.6667	No	No	No	Yes	8	9
161	3x40	6x44	Shared	100	100	No	No	Yes	Yes	8	9
162	3x41	4x49	Shared	100	100	Yes	No	No	No	6	6
163	3x41	4x52	Shared	100	41.6667	Yes	No	No	No	6	4
164	3x44	5x53	Shared	100	100	No	No	No	No	6	6
165	3x49	I2x53	Shared	100	100	Yes	Yes	Yes	Yes	9	7
166	3x51	3x55	Shared	100	100	No	Yes	No	No	8	7
167	3x51	5x60	Shared	100	100	No	Yes	No	No	8	5
168	3x52	I2x53	Shared	100	50	No	Yes	Yes	Yes	5	7
169	3x53	I2x53	Shared	100	100	No	No	Yes	Yes	8	7
170	I2x53	I2x57	Shared	100	100	Yes	Yes	Yes	No	7	6
171	4x38	4x41	Shared	100	100	No	No	No	No	8	7
172	4x63	E2	Shared	100	50	No	No	Yes	Yes	5	3
173	4x64	E2	Shared	100	100	No	No	Yes	Yes	5	3
174	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
175	E2	E2x52	Shared	100	100	Yes	Yes	No	No	3	4
176	5x39	E2	Shared	100	100	No	No	Yes	Yes	7	3
177	5x36	E2	Shared	100	100	No	No	Yes	Yes	5	3
178	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	5
179	E2x52	Lig	Shared	100	100	No	No	Yes	Yes	4	0
180	5x39	5x43	Shared	100	100	No	No	No	No	7	6
181	5x43	Lig	Shared	100	100	No	No	Yes	Yes	6	0
182	5x47	5x48	Shared	100	100	Yes	Yes	No	No	7	5
183	5x47	5x51	Shared	100	100	Yes	Yes	No	No	7	6
184	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	7	7
185	5x58	6x41	Shared	100	100	Yes	Yes	Yes	No	9	8
186	5x62	5x66	Shared	100	100	No	Yes	No	No	6	5
187	5x64	5x67	Shared	100	100	No	No	No	No	6	4
188	6x39	7x52	Shared	100	18.75	No	No	No	No	7	8
189	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
190	6x47	7x45	Shared	100	100	No	No	No	No	8	9
191	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
192	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	6
193	6x49	6x53	Shared	100	100	No	Yes	No	No	7	6
194	6x50	7x37	Shared	100	100	No	No	No	Yes	9	5
195	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	7	7
196	6x51	7x34	Shared	100	100	Yes	Yes	No	No	7	4
197	6x51	7x38	Shared	100	100	Yes	Yes	No	No	7	6
198	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
199	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
200	6x54	7x37	Shared	100	100	No	No	No	Yes	4	5
201	6x55	7x34	Shared	100	100	No	Yes	No	No	6	4
202	6x55	Lig	Shared	100	100	No	Yes	Yes	Yes	6	0
203	6x57	E3	Shared	100	54.1667	No	No	Yes	Yes	5	4
204	6x61	E3	Shared	100	100	No	No	Yes	Yes	4	4
205	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	4	4
206	7x30	7x32	Shared	100	100	No	No	No	No	5	3
207	7x30	7x33	Shared	100	50	No	No	No	No	5	4
208	7x33	7x37	Shared	100	75	No	No	No	Yes	4	5
209	7x38	7x42	Shared	100	100	No	No	Yes	Yes	6	7
210	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
211	7x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
212	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
213	7x54	8x54	Shared	100	100	No	No	Yes	Yes	6	7
214	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	8
215	8x50	8x54	Shared	100	100	Yes	Yes	Yes	Yes	8	7
216	3x34	4x57	Shared	100	100	No	No	No	No	5	7
217	6x58	E3	Shared	100	100	No	No	Yes	Yes	4	4
218	3x41	5x50	Shared	100	50	Yes	No	No	Yes	6	9
219	3x49	I2x57	Shared	100	100	Yes	Yes	Yes	No	9	6
220	5x40	6x55	Shared	100	100	No	No	No	Yes	6	6
221	5x58	5x61	Shared	100	12.5	Yes	Yes	No	No	9	9
222	6x27	6x31	Shared	100	18.75	No	No	Yes	No	0	5
223	1x46	2x54	Shared	62.5	54.1667	No	No	No	No	7	7
224	2x42	3x49	Shared	87.5	100	Yes	Yes	Yes	Yes	8	9
225	2x42	4x42	Shared	75	100	Yes	Yes	No	No	8	7
226	I1x48	I1x51	Shared	75	100	No	No	No	No	6	7
227	1x50	2x47	Shared	51.7857	41.6667	Yes	Yes	No	No	9	8
228	5x47	6x49	Shared	66.0714	100	Yes	Yes	No	Yes	7	7
229	5x56	5x60	Shared	50	47.9167	No	No	No	No	5	5
230	5x44	6x52	Shared	75	100	No	No	Yes	Yes	6	7
231	6x43	7x52	Shared	57.1429	100	No	No	No	No	6	8
232	1x57	2x40	Shared	62.5	100	No	No	No	Yes	7	9
233	2x38	4x39	Shared	50	35.4167	No	No	No	No	6	3
234	1x43	2x58	Shared	68.75	66.6667	No	No	No	No	5	9
235	5x49	5x50	Shared	62.5	43.75	No	No	No	Yes	5	9
236	1x46	7x47	Shared	47.3214	66.6667	No	No	No	No	7	6
237	5x40	6x59	Shared	50	66.6667	No	No	No	No	6	5
238	3x48	3x52	Shared	25	58.3333	No	No	No	Yes	6	5
239	6x35	6x39	Shared	57.1429	43.75	No	No	No	No	7	7
240	2x551	3x31	Shared	75	33.3333	No	No	No	No	4	5
241	1x43	2x57	Shared	25	100	No	No	No	No	5	7
242	4x60	5x39	Shared	50	100	No	No	No	No	7	7
243	3x31	3x35	Shared	50	25	No	No	No	No	5	6
244	1x54	2x47	Shared	41.0714	37.5	No	No	No	No	7	8
245	3x54	5x64	Shared	50	37.5	No	No	No	No	9	6
246	4x61	E2	Shared	56.25	100	No	No	Yes	Yes	6	3
247	1x52	8x58	Shared	62.5	45.8333	No	No	No	No	6	6
248	5x51	5x55	Shared	75	50	No	No	No	No	6	5
249	1x47	2x55	Shared	62.5	8.33333	No	No	No	No	6	5
250	4x59	4x60	Shared	53.5714	100	No	No	No	No	6	7
251	2x42	4x45	Shared	37.5	29.1667	Yes	Yes	No	No	8	6
252	1x45	7x51	Shared	50	25	No	No	No	No	5	6
253	1x60	8x53	Shared	62.5	56.25	Yes	Yes	No	No	6	7
254	3x37	4x56	Shared	50	75	Yes	No	No	No	6	5
255	1x32	2x65	Shared	28.5714	20.8333	No	No	No	No	5	5
256	3x30	4x62	Shared	50	16.6667	No	No	No	No	6	4
257	5x36	5x38	Shared	25	54.1667	No	No	No	No	5	4
258	7x43	7x48	Shared	50	14.5833	No	No	No	No	4	6
259	1x55	8x57	Shared	31.25	37.5	No	No	No	No	4	6
260	1x52	8x57	Shared	7.14286	37.5	No	No	No	No	6	6
261	6x43	7x48	Shared	28.5714	45.8333	No	No	No	No	6	6
262	1x56	8x54	Shared	25	31.25	No	No	Yes	Yes	7	7
263	1x50	2x51	Shared	0	70.8333	Yes	Yes	No	No	9	7
264	7x55	7x56	Shared	50	25	No	No	No	No	7	0
265	5x60	5x63	Shared	50	20.8333	No	No	No	No	5	4
266	3x34	4x54	Shared	16.0714	0	No	No	No	No	5	3
267	2x49	4x50	Shared	0	20.8333	No	No	Yes	No	8	9
268	3x21	E1x50	Shared	0	41.6667	No	No	Yes	Yes	7	7
269	8x51	8x55	Shared	25	31.25	No	No	No	No	8	4
270	1x60	8x56	Shared	37.5	56.25	Yes	Yes	No	No	6	4
271	8x47	8x48	Shared	50	50	No	No	No	No	8	6
272	4x56	5x46	Shared	25	25	No	No	No	No	5	4
273	1x48	1x49	Shared	0	6.25	No	No	No	No	4	8
274	1x54	2x48	Shared	0	27.0833	No	No	No	No	7	5
275	1x45	7x47	Shared	12.5	25	No	No	No	No	5	6
276	3x56	I2x50	Shared	7.14286	0	No	No	No	No	6	8
277	4x38	4x40	Shared	0	20.8333	No	No	No	No	8	5
278	1x35	1x39	Shared	6.25	16.6667	No	No	No	No	4	6
279	1x35	2x65	Shared	0	16.6667	No	No	No	No	4	5
280	8x48	8x52	Shared	12.5	50	No	No	No	No	6	4
281	5x41	6x60	Shared	12.5	16.6667	No	No	No	No	5	5
282	1x59	1x60	Shared	3.57143	41.6667	No	No	Yes	Yes	5	6
283	4x48	4x52	Shared	0	6.25	No	No	No	No	3	4
284	4x47	4x51	Shared	3.57143	4.16667	No	No	No	No	4	4
285	6x41	6x42	Shared	0	0	Yes	No	No	No	8	5
286	7x36	7x40	Shared	12.5	66.6667	No	No	No	No	5	7
287	8x58	8x59	Shared	12.5	2.08333	No	No	No	No	6	3
288	1x36	2x65	Shared	0	4.16667	No	No	No	No	5	5
289	4x55	4x59	Shared	7.14286	14.5833	No	No	No	No	4	6
290	1x44	1x48	Shared	3.57143	18.75	No	No	No	No	5	4
291	5x55	5x59	Shared	0	0	No	No	No	No	5	2
292	5x52	5x56	Shared	0	4.16667	No	No	No	No	3	5
293	1x34	1x37	Shared	0	4.16667	No	No	No	No	4	4
294	1x38	7x39	Shared	12.5	16.6667	No	No	Yes	Yes	5	6
295	1x40	1x43	Shared	0	12.5	No	No	No	No	4	5
296	2x67	E1x49	Shared	0	0	No	No	No	No	4	3
297	1x53	7x54	adrenergic_on	0	100	No	No	No	No	9	6
298	2x40	I1x50	adrenergic_on	0	100	No	Yes	No	No	9	8
299	2x40	8x50	adrenergic_on	0	100	No	Yes	Yes	Yes	9	8
300	2x46	2x50	adrenergic_on	0	100	No	Yes	No	Yes	9	9
301	2x46	3x42	adrenergic_on	0	100	No	Yes	No	No	9	8
302	2x46	7x49	adrenergic_on	0	100	No	Yes	No	Yes	9	9
303	2x50	3x39	adrenergic_on	0	100	No	Yes	No	No	9	9
304	2x56	3x28	adrenergic_on	0	100	No	No	Yes	Yes	7	6
305	3x25	E1x50	adrenergic_on	0	100	No	No	Yes	Yes	9	7
306	3x40	6x48	adrenergic_on	0	100	No	No	Yes	Yes	8	8
307	3x43	7x49	adrenergic_on	0	100	No	No	No	Yes	8	9
308	3x43	7x53	adrenergic_on	0	100	No	No	Yes	Yes	8	9
309	3x46	3x50	adrenergic_on	0	100	No	No	Yes	No	9	9
310	3x46	7x53	adrenergic_on	0	100	No	No	Yes	Yes	9	9
311	3x47	5x58	adrenergic_on	0	100	No	No	Yes	Yes	8	9
312	3x50	5x58	adrenergic_on	0	100	Yes	No	Yes	Yes	9	9
313	3x50	7x53	adrenergic_on	0	100	Yes	No	Yes	Yes	9	9
314	3x51	5x57	adrenergic_on	0	100	No	Yes	No	No	8	6
315	3x56	I2x52	adrenergic_on	0	100	No	No	No	Yes	6	5
316	4x60	E2	adrenergic_on	0	100	No	No	Yes	Yes	7	3
317	5x44	6x56	adrenergic_on	0	100	No	No	No	No	6	5
318	5x461	Lig	adrenergic_on	0	100	No	No	Yes	Yes	6	0
319	5x47	6x44	adrenergic_on	0	100	Yes	Yes	Yes	Yes	7	9
320	5x51	6x44	adrenergic_on	0	100	No	No	Yes	Yes	6	9
321	5x54	6x44	adrenergic_on	0	100	No	No	Yes	Yes	8	9
322	5x58	6x37	adrenergic_on	0	100	Yes	Yes	No	No	9	8
323	5x58	6x40	adrenergic_on	0	100	Yes	Yes	No	No	9	8
324	5x62	6x34	adrenergic_on	0	100	No	Yes	No	No	6	7
325	5x66	6x30	adrenergic_on	0	100	No	No	No	No	5	7
326	6x48	7x45	adrenergic_on	0	100	Yes	Yes	No	No	8	9
327	6x49	6x50	adrenergic_on	0	100	No	Yes	No	No	7	9
328	6x51	7x37	adrenergic_on	0	100	Yes	Yes	No	Yes	7	5
329	7x45	7x49	adrenergic_on	0	100	No	No	No	Yes	9	9
330	7x52	7x53	adrenergic_on	0	100	No	No	Yes	Yes	8	9
331	7x54	8x50	adrenergic_on	0	100	No	No	Yes	Yes	6	8
332	6x51	6x55	adrenergic_on	0	100	Yes	Yes	No	Yes	7	6
333	2x66	E1x49	adrenergic_on	0	100	No	No	No	No	4	3
334	6x45	6x49	adrenergic_on	0	68.75	No	No	No	Yes	5	7
335	3x51	3x52	adrenergic_on	0	62.5	No	Yes	No	Yes	8	5
336	5x69	6x29	adrenergic_on	0	58.3333	No	Yes	No	No	5	6
337	3x24	E1x52	adrenergic_on	0	68.75	No	No	Yes	Yes	4	5
338	5x37	6x60	adrenergic_on	0	68.75	No	No	No	No	5	5
339	1x53	2x47	adrenergic_on	0	62.5	No	No	No	No	9	8
340	5x62	6x37	adrenergic_on	0	52.0833	No	Yes	No	No	6	8
341	2x54	2x57	adrenergic_on	0	54.1667	No	No	No	No	7	7
342	8x47	8x49	adrenergic_on	0	41.6667	No	No	No	No	8	6
343	3x52	3x56	adrenergic_on	0	54.1667	No	Yes	No	No	5	6
344	2x38	I2x57	adrenergic_on	0	45.8333	No	No	Yes	No	6	6
345	6x36	7x56	adrenergic_on	0	50	No	No	No	No	8	0
346	3x44	5x50	adrenergic_on	0	39.5833	No	No	No	Yes	6	9
347	3x54	5x61	adrenergic_on	0	47.9167	No	No	No	No	9	9
348	E2	E3	adrenergic_on	0	50	Yes	Yes	Yes	Yes	3	4
349	5x65	6x33	adrenergic_on	0	50	No	No	No	No	8	8
350	6x31	6x35	adrenergic_on	0	56.25	Yes	No	No	No	5	7
351	I2x53	I2x54	adrenergic_on	0	50	Yes	Yes	No	No	7	5
352	1x42	7x39	adrenergic_on	0	52.0833	No	No	Yes	Yes	6	6
353	2x55	2x551	adrenergic_on	0	41.6667	No	No	No	No	5	4
354	4x39	4x43	adrenergic_on	0	50	No	No	No	No	3	4
355	5x69	6x30	adrenergic_on	0	25	No	Yes	No	No	5	7
356	2x43	8x50	adrenergic_on	0	18.75	No	No	Yes	Yes	7	8
357	7x31	7x32	adrenergic_on	0	43.75	No	No	No	No	3	3
358	7x55	8x51	adrenergic_on	0	31.25	No	No	No	No	7	8
359	I2x52	I2x56	adrenergic_on	0	35.4167	No	Yes	No	No	5	5
360	6x59	6x60	adrenergic_on	0	37.5	No	No	No	No	5	5
361	5x62	6x33	adrenergic_on	0	29.1667	No	Yes	No	No	6	8
362	3x28	3x29	adrenergic_on	0	8.33333	Yes	Yes	No	No	6	6
363	5x45	5x48	adrenergic_on	0	20.8333	No	No	No	No	4	5
364	5x74	5x75	adrenergic_on	0	16.6667	No	No	No	No	0	0
365	5x73	I3	adrenergic_on	0	33.3333	No	No	Yes	No	0	0
366	8x52	8x55	adrenergic_on	0	31.25	No	No	No	No	4	4
367	7x36	7x37	adrenergic_on	0	29.1667	No	No	No	Yes	5	5
368	6x32	6x36	adrenergic_on	0	20.8333	No	No	No	No	8	8
369	5x75	I3	adrenergic_on	0	16.6667	No	No	Yes	No	0	0
370	3x27	4x58	adrenergic_on	0	33.3333	No	No	No	No	4	5
371	2x62	2x66	adrenergic_on	0	25	No	No	No	No	4	4
372	5x69	6x26	adrenergic_on	0	25	No	Yes	No	No	5	0
373	3x23	3x24	adrenergic_on	0	14.5833	No	No	No	No	2	4
374	4x41	I2x53	adrenergic_on	0	25	No	No	Yes	Yes	7	7
375	5x68	5x71	adrenergic_on	0	20.8333	No	No	No	No	7	0
376	I2x51	I2x52	adrenergic_on	0	8.33333	No	No	No	Yes	6	5
377	5x67	5x70	adrenergic_on	0	16.6667	No	No	No	No	4	0
378	5x67	5x68	adrenergic_on	0	6.25	No	No	No	No	4	7
379	4x40	4x44	adrenergic_on	0	14.5833	No	No	No	No	5	3
380	5x72	6x29	adrenergic_on	0	16.6667	No	No	No	No	0	6
381	5x69	5x73	adrenergic_on	0	16.6667	No	Yes	No	No	5	0
382	4x56	5x42	adrenergic_on	0	6.25	No	No	No	No	5	4
383	5x72	5x76	adrenergic_on	0	4.16667	No	No	No	No	0	0
384	2x41	I1x51	adrenergic_on	0	10.4167	No	No	No	No	5	7
385	1x29	1x31	adrenergic_on	0	18.75	No	No	No	Yes	0	3
386	I2x52	I2x55	adrenergic_on	0	0	No	Yes	No	No	5	5
387	1x31	1x34	adrenergic_on	0	4.16667	No	Yes	No	No	3	4
388	1x54	1x58	adrenergic_on	0	2.08333	No	No	No	No	7	2
389	1x40	1x41	adrenergic_on	0	0	No	No	No	No	4	4
390	6x46	6x47	adrenergic_on	0	2.08333	No	No	No	No	5	8
391	6x28	6x29	adrenergic_on	0	4.16667	No	No	No	No	0	6
392	1x30	1x31	adrenergic_on	0	6.25	No	No	No	Yes	2	3
393	6x38	6x41	adrenergic_on	0	0	No	No	Yes	No	5	8
394	4x46	4x47	adrenergic_on	0	4.16667	No	No	No	No	7	4
395	1x33	1x34	adrenergic_on	0	0	No	No	No	No	5	4
396	6x25	6x28	adrenergic_on	0	0	No	No	No	No	0	0
397	6x23	6x26	adrenergic_on	0	2.08333	No	No	No	No	0	0
398	6x24	6x25	adrenergic_on	0	0	No	No	No	No	0	0
399	6x22	6x24	adrenergic_on	0	0	No	No	No	No	0	0

Orange: nodes, hubs and links specific of adrenergic_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of adrenergic_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	adrenergic_off Avg Int. Strength	adrenergic_on Avg Int. Strength	adrenergic_off Num Of Links	adrenergic_on Num Of Links	ConSurf
1	3x37	adrenergic_off	0	0	4	3	6
2	3x41	adrenergic_off	25	0	4	3	6
3	3x50	adrenergic_off	25	0	5	3	9
4	I2x57	adrenergic_off	12.5	0	4	3	6
5	4x50	adrenergic_off	0	0	4	3	9
6	6x31	adrenergic_off	0	0	4	2	5
7	6x41	adrenergic_off	0	0	4	3	8
8	I3	adrenergic_off	0	0	6	2	0
9	1x50	Shared	0	0	4	4	9
10	1x60	Shared	0	0	5	4	6
11	2x42	Shared	46.4286	0	6	5	8
12	E1x50	Shared	62.5	68.75	5	6	7
13	E1x52	Shared	42.8571	0	4	4	5
14	3x28	Shared	43.75	22.9167	4	5	6
15	3x49	Shared	58.9286	12.5	6	4	9
16	I2x53	Shared	50	0	6	6	7
17	E2	Shared	100	75	14	14	3
18	5x47	Shared	25	97.9167	4	5	7
19	5x58	Shared	0	97.9167	5	6	9
20	6x44	Shared	75	77.0833	5	5	9
21	6x48	Shared	96.4286	100	5	6	8
22	6x51	Shared	96.4286	75	5	6	7
23	6x52	Shared	83.9286	95.8333	5	5	7
24	E3	Shared	74.1071	33.3333	6	6	4
25	7x39	Shared	0	0	4	5	6
26	7x42	Shared	87.5	97.9167	6	6	7
27	7x53	Shared	50	70.8333	5	4	9
28	8x50	Shared	50	62.5	4	6	8
29	8x54	Shared	0	0	4	4	7
30	Lig	Shared	100	100	14	11	0
31	1x31	adrenergic_on	0	0	2	4	3
32	2x40	adrenergic_on	0	33.3333	3	4	9
33	2x46	adrenergic_on	0	29.1667	1	4	9
34	2x50	adrenergic_on	6.25	66.6667	3	5	9
35	3x51	adrenergic_on	0	0	3	4	8
36	3x52	adrenergic_on	0	0	2	4	5
37	I2x52	adrenergic_on	0	0	2	4	5
38	5x50	adrenergic_on	0	0	3	4	9
39	5x62	adrenergic_on	0	0	2	4	6
40	5x69	adrenergic_on	0	0	1	4	5
41	6x49	adrenergic_on	0	8.33333	2	4	7
42	6x55	adrenergic_on	0	0	3	4	6
43	7x37	adrenergic_on	0	0	3	5	5
44	7x49	adrenergic_on	0	75	3	4	9

Orange: nodes, hubs and links specific of adrenergic_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of adrenergic_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	adrenergic_off Recurrence	adrenergic_on Recurrence	adrenergic_off Hub1?	adrenergic_on Hub1?	adrenergic_off Hub2?	adrenergic_on Hub2?	ConSurf1	ConSurf2
1	2x53	2x56	adrenergic_off	100	0	No	No	No	No	8	7
2	2x53	7x46	adrenergic_off	93.3517	8.35008	No	No	No	No	8	9
3	2x50	7x46	adrenergic_off	83.8528	9.52271	No	Yes	No	No	9	9
4	7x49	7x53	adrenergic_off	44.0382	0	No	Yes	Yes	Yes	9	9
5	7x53	8x50	adrenergic_off	35.3908	0	Yes	Yes	Yes	Yes	9	8
6	8x50	8x54	adrenergic_off	13.0166	0.340189	Yes	Yes	Yes	Yes	8	7
7	8x50	I1x50	adrenergic_off	13.415	5.39147	Yes	Yes	No	No	8	8
8	1x60	I1x50	adrenergic_off	12.2083	4.53327	Yes	Yes	No	No	6	8
9	3x33	Lig	adrenergic_off	38.1526	4.67759	No	No	Yes	Yes	6	0
10	3x33	4x57	adrenergic_off	37.4513	3.51528	No	No	No	No	6	7
11	3x34	4x57	adrenergic_off	31.0876	2.34782	No	No	No	No	5	7
12	3x34	4x50	adrenergic_off	29.594	0	No	No	Yes	No	5	9
13	2x45	4x50	adrenergic_off	33.2028	3.25241	No	No	Yes	No	9	9
14	2x42	4x42	adrenergic_off	10.3003	1.07211	Yes	Yes	No	No	8	7
15	7x38	7x42	adrenergic_off	10.9742	1.42261	No	No	Yes	Yes	6	7
16	6x51	7x38	adrenergic_off	10.9287	1.79888	Yes	Yes	No	No	7	6
17	6x48	6x51	adrenergic_off	30.6801	0	Yes	Yes	Yes	Yes	8	7
18	6x44	6x48	adrenergic_off	68.7325	5.87083	Yes	Yes	Yes	Yes	9	8
19	3x43	6x44	adrenergic_off	54.869	0	No	No	Yes	Yes	8	9
20	6x51	Lig	adrenergic_off	28.1938	2.96634	Yes	Yes	Yes	Yes	7	0
21	3x28	Lig	adrenergic_off	13.8339	0	Yes	Yes	Yes	Yes	6	0
22	E2	Lig	adrenergic_off	23.2007	0	Yes	Yes	Yes	Yes	3	0
23	3x40	6x44	adrenergic_off	12.5316	0.275759	No	No	Yes	Yes	8	9
24	3x40	5x50	adrenergic_off	10.808	8.40936	No	No	No	Yes	8	9
25	3x43	6x41	adrenergic_off	51.0348	0	No	No	Yes	No	8	8
26	5x58	6x41	adrenergic_off	41.347	3.62868	Yes	Yes	Yes	No	9	8
27	5x58	5x61	adrenergic_off	20.2614	7.93516	Yes	Yes	No	No	9	9
28	3x51	5x61	adrenergic_off	18.2555	0	No	Yes	No	No	8	9
29	6x40	7x49	adrenergic_off	20.1248	0	No	No	No	Yes	8	9
30	6x40	7x52	adrenergic_off	19.4372	0	No	No	No	No	8	8
31	6x51	7x34	adrenergic_off	11.8485	0.719035	Yes	Yes	No	No	7	4
32	6x54	7x34	adrenergic_off	17.4245	0	No	No	No	No	4	4
33	6x55	Lig	adrenergic_off	12.7843	6.85016	No	Yes	Yes	Yes	6	0
34	5x58	I3	adrenergic_off	14.098	0	Yes	Yes	Yes	No	9	0
35	7x39	7x42	Shared	11.1382	17.3909	Yes	Yes	Yes	Yes	6	7
36	2x56	7x42	Shared	56.3375	19.3186	No	No	Yes	Yes	7	7
37	1x50	2x50	Shared	19.3689	44.3405	Yes	Yes	No	Yes	9	9
38	2x50	7x49	Shared	65.6201	42.472	No	Yes	No	Yes	9	9
39	7x42	Lig	Shared	55.4678	44.2219	Yes	Yes	Yes	Yes	7	0
40	2x45	4x46	Shared	31.9278	37.0677	No	No	No	No	9	7
41	2x42	4x46	Shared	31.2834	34.3539	Yes	Yes	No	No	8	7
42	2x42	3x49	Shared	20.0542	30.6221	Yes	Yes	Yes	Yes	8	9
43	3x36	Lig	Shared	21.1084	44.3018	No	No	Yes	Yes	6	0
44	3x36	6x48	Shared	20.612	44.4127	No	No	Yes	Yes	6	8
45	6x52	Lig	Shared	27.4379	48.2372	Yes	Yes	Yes	Yes	7	0
46	6x48	6x52	Shared	21.698	55.3167	Yes	Yes	Yes	Yes	8	7
47	3x49	I2x53	Shared	14.18	21.9963	Yes	Yes	Yes	Yes	9	7
48	2x56	3x32	Shared	44.9762	17.7929	No	No	No	No	7	7
49	3x32	Lig	Shared	45.402	18.6279	No	No	Yes	Yes	7	0
50	1x39	7x39	adrenergic_on	6.85777	12.6153	No	No	Yes	Yes	6	6
51	2x57	7x42	adrenergic_on	3.91385	11.3628	No	No	Yes	Yes	7	7
52	6x48	7x45	adrenergic_on	0	100	Yes	Yes	No	No	8	9
53	7x45	7x49	adrenergic_on	0	98.9562	No	No	No	Yes	9	9
54	1x50	2x47	adrenergic_on	4.90198	37.2507	Yes	Yes	No	No	9	8
55	1x53	2x47	adrenergic_on	0	33.0859	No	No	No	No	9	8
56	1x53	7x54	adrenergic_on	0	32.0319	No	No	No	No	9	6
57	7x54	8x50	adrenergic_on	0	23.5374	No	No	Yes	Yes	6	8
58	2x46	7x49	adrenergic_on	0	31.4494	No	Yes	No	Yes	9	9
59	2x46	3x42	adrenergic_on	0	41.4875	No	Yes	No	No	9	8
60	2x45	3x42	adrenergic_on	0.846975	40.6139	No	No	No	No	9	8
61	8x47	8x50	adrenergic_on	8.14872	12.2648	No	No	Yes	Yes	8	8
62	3x43	7x49	adrenergic_on	0	36.1399	No	No	No	Yes	8	9
63	2x56	3x28	adrenergic_on	0	35.2636	No	No	Yes	Yes	7	6
64	2x59	3x28	adrenergic_on	5.84914	10.6824	No	No	Yes	Yes	4	6
65	3x28	E1x50	adrenergic_on	6.59593	18.7774	Yes	Yes	Yes	Yes	6	7
66	E2x52	Lig	adrenergic_on	1.49359	25.1637	No	No	Yes	Yes	4	0
67	E2	E2x52	adrenergic_on	0.10701	24.3518	Yes	Yes	No	No	3	4
68	3x43	7x53	adrenergic_on	0	45.8971	No	No	Yes	Yes	8	9
69	3x50	7x53	adrenergic_on	0	35.8126	Yes	No	Yes	Yes	9	9
70	3x50	5x58	adrenergic_on	0	34.9363	Yes	No	Yes	Yes	9	9
71	3x52	I2x53	adrenergic_on	3.37652	15.6332	No	Yes	Yes	Yes	5	7
72	5x58	6x37	adrenergic_on	0	21.4963	Yes	Yes	No	No	9	8
73	5x62	6x37	adrenergic_on	0	20.334	No	Yes	No	No	6	8
74	5x62	5x66	adrenergic_on	2.04458	16.1512	No	Yes	No	No	6	5
75	5x66	6x30	adrenergic_on	0	15.0018	No	No	No	No	5	7
76	5x69	6x30	adrenergic_on	0	14.0173	No	Yes	No	No	5	7
77	1x35	1x39	adrenergic_on	5.38922	10.6464	No	No	No	No	4	6
78	2x46	2x50	adrenergic_on	0	11.5561	No	Yes	No	Yes	9	9
79	2x46	3x43	adrenergic_on	2.04458	10.8139	No	Yes	No	No	9	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	6.19196	8.9975	1	1	2	1
2x56	7x42	Shared	3.83375	4.08375	1	1	2	1
2x57	7x42	Shared	4.89402	5.17937	0	0	2	1
2x59	3x28	Shared	7.77902	7.27646	0	0	2	1
2x60	3x28	Shared	4.96179	3.98313	0	0	2	1
E1x49	E2	Shared	4.44348	2.69646	1	1	2	1
3x28	E1x50	Shared	8.12554	7.41792	1	0	1	2
3x22	E2	Shared	7.14071	4.05208	0	0	2	1
3x26	4x64	adrenergic_off	5.03446	0	1	0	2	2
3x26	E2	Shared	6.83054	3.02979	1	0	2	1
3x28	Lig	adrenergic_off	6.38509	0	1	0	1	0
3x29	E2x52	adrenergic_off	4.74768	0	0	0	2	1
3x32	7x42	Shared	8.51714	9.17083	1	1	1	1
3x32	Lig	Shared	19.1031	13.369	1	1	1	0
3x33	4x57	Shared	5.23589	3.93708	1	0	1	2
3x33	Lig	Shared	8.75982	9.71187	1	0	1	0
3x36	6x48	Shared	8.51205	6.94667	1	0	1	2
3x36	Lig	Shared	4.1133	7.77458	1	0	1	0
3x37	4x57	adrenergic_off	4.18446	0	0	0	2	2
3x37	5x461	Shared	8.22268	7.55958	0	0	2	1
4x63	E2	Shared	6.6275	2.42042	0	0	2	1
4x64	E2	Shared	11.2674	5.08771	1	0	2	1
E2	E2	Shared	69.7118	44.8317	1	1	1	1
E2	E2x52	Shared	7.65062	5.74667	1	1	1	1
5x39	E2	Shared	9.74545	7.89646	1	1	2	1
5x36	E2	Shared	5.55313	3.43437	1	1	2	1
E2	E2x51	Shared	8.82679	7.2125	1	1	1	2
E2x52	Lig	Shared	9.00286	10.085	1	1	1	0
E2	Lig	adrenergic_off	4.00339	0	1	1	1	0
5x39	5x43	Shared	12.6495	8.08104	1	1	2	1
5x43	Lig	Shared	4.57893	6.085	1	0	1	0
5x47	6x52	Shared	27.3565	18.1725	0	1	2	1
6x48	6x51	adrenergic_off	5.73598	0	1	1	2	1
6x48	6x52	Shared	5.3325	6.8275	1	1	2	1
6x51	6x52	Shared	8.6992	7.27958	1	1	1	1
6x51	7x34	Shared	5.85786	4.29562	1	1	1	2
6x51	7x38	Shared	9.45571	11.7077	1	1	1	1
6x51	Lig	Shared	10.4362	11.5465	1	1	1	0
6x52	Lig	Shared	8.97357	5.98104	1	1	1	0
6x55	7x34	Shared	3.92571	3.77104	1	1	1	2
6x55	Lig	Shared	5.72964	3.66188	1	1	1	0
E3	E3	Shared	5.16714	6.3775	4	1	2	2
7x38	7x42	Shared	8.60973	8.47042	1	1	1	1
7x38	Lig	Shared	14.471	14.7213	1	1	1	0
7x39	7x42	Shared	9.23071	5.20625	0	0	2	1
7x42	Lig	Shared	4.56857	6.62354	1	1	1	0
5x40	6x55	Shared	4.34839	3.54375	0	0	2	1
5x44	6x52	Shared	3.49161	3.87604	0	0	2	1
4x60	5x39	Shared	3.07786	7.33021	0	1	2	2
4x61	E2	Shared	3.03795	3.97542	1	1	2	1
E2	NT	adrenergic_off	2.43375	0	1	1	1	2
2x56	3x28	adrenergic_on	0	4.25812	1	1	2	1
4x60	E2	adrenergic_on	0	3.84583	0	1	2	1
5x461	Lig	adrenergic_on	0	4.11771	0	0	1	0
6x51	7x37	adrenergic_on	0	3.45146	1	1	1	2
6x51	6x55	adrenergic_on	0	5.66625	1	1	1	1
E2	E3	adrenergic_on	0	2.515	1	1	1	2
3x28	3x29	adrenergic_on	0	1.66646	1	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	adrenergic_off	beta_off alpha_off
	adrenergic_on	beta_on alpha_on

Network Difference
Value	adrenergic_off	adrenergic_on
I_min	3.6525	3.38188
Number of Linked Nodes	275	271
Number of Specific Nodes	6 (2.18%)	2 (0.74%)
Number of Shared Nodes	269 (97.82%)	269 (99.26%)
Number of Links	296	294
Number of Specific Links	105 (35.47%)	103 (35.03%)
Number of Shared Links	191 (64.53%)	191 (64.97%)
Number of Hubs	30	36
Number of Specific Hubs	8 (26.67%)	14 (38.89%)
Number of Shared Hubs	22 (73.33%)	22 (61.11%)
Average % Shared Neighbours (Jaccard)	53.22
Average % Shared Neighbours (Otsuka)	61.05
Average % Shared Neighbours (Overlap Coefficient)	69.32
Average % Shared Cliques (k3-6)	81.52
Graphlets Similarity	0.579545

Paths Difference
Value	adrenergic_off	adrenergic_on
Number Of Nodes in MetaPath	46	42
Specific Nodes in MetaPath	24 (52.17%)	20 (47.62%)
Shared Nodes in MetaPath	269 (97.82%)	269 (97.82%)
Number Of Links MetaPath	49	45
Specific Links in MetaPath	34 (69.39%)	30 (66.67%)
Shared Links in MetaPath	191 (64.53%)	191 (64.53%)
Number of Shortest Paths	76262	62972
Length Of Smallest Path	3	3
Average Path Length	13.891	13.7595
Length of Longest Path	29	30
Minimum Path Strength	0.602679	0.316458
Average Path Strength	5.90299	5.5321
Maximum Path Strength	18.4777	12.9583
Minimum Path Correlation	0.703214	0.700208
Average Path Correlation	0.91332	0.888712
Maximum Path Correlation	0.988125	0.986042
Minimum % Of Corr. Nodes	3.7037	3.7037
Average % Of Corr. Nodes	44.3252	38.9969
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	36.5726	46.4367
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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