psnGPCR

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Orange: nodes, hubs and links specific of alpha1a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha1a_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	alpha1a_off Int. Strength	alpha1a_on Int. Strength	alpha1a_off Hub1?	alpha1a_on Hub1?	alpha1a_off Hub2?	alpha1a_on Hub2?	ConSurf1	ConSurf2
1	1x30	1x33	alpha1a_off	100	0	No	No	No	No	4	6
2	1x53	8x54	alpha1a_off	100	0	No	No	Yes	No	9	7
3	1x54	2x47	alpha1a_off	100	0	No	No	No	No	7	9
4	1x60	I1x49	alpha1a_off	100	0	Yes	Yes	No	No	6	6
5	2x41	I1x51	alpha1a_off	100	0	No	No	No	No	5	8
6	2x39	3x50	alpha1a_off	100	0	No	No	Yes	Yes	8	9
7	2x42	3x46	alpha1a_off	100	0	Yes	Yes	No	No	8	9
8	2x42	4x46	alpha1a_off	100	0	Yes	Yes	No	No	8	8
9	2x43	7x53	alpha1a_off	100	0	No	No	No	Yes	7	9
10	2x53	2x56	alpha1a_off	100	0	Yes	No	Yes	Yes	8	8
11	2x59	3x24	alpha1a_off	100	0	No	No	No	No	5	5
12	2x63	Lig	alpha1a_off	100	0	No	No	Yes	Yes	4	0
13	2x64	Lig	alpha1a_off	100	0	No	No	Yes	Yes	5	0
14	3x22	E2.P170	alpha1a_off	100	0	Yes	No	No	No	5	4
15	3x28	Lig	alpha1a_off	100	0	Yes	Yes	Yes	Yes	5	0
16	3x34	4x54	alpha1a_off	100	0	No	No	No	No	6	4
17	3x39	7x45	alpha1a_off	100	0	Yes	No	Yes	No	9	9
18	3x39	7x49	alpha1a_off	100	0	Yes	No	Yes	Yes	9	9
19	3x41	4x53	alpha1a_off	100	0	Yes	No	No	No	6	8
20	3x41	5x49	alpha1a_off	100	0	Yes	No	No	No	6	5
21	3x41	5x50	alpha1a_off	100	0	Yes	No	No	No	6	9
22	4x60	4x64	alpha1a_off	100	0	Yes	No	No	No	7	6
23	4x60	5x42	alpha1a_off	100	0	Yes	No	No	No	7	5
24	4x61	5x39	alpha1a_off	100	0	No	No	Yes	Yes	5	8
25	4x64	5x38	alpha1a_off	100	0	No	No	No	No	6	5
26	5x36	E2.Q167	alpha1a_off	100	0	No	No	No	No	6	5
27	5x36	E2.N179	alpha1a_off	100	0	No	No	No	No	6	5
28	5x54	6x41	alpha1a_off	100	0	No	No	No	No	8	8
29	5x58	I3.L235	alpha1a_off	100	0	Yes	Yes	No	No	9	5
30	5x68	5x71	alpha1a_off	100	0	No	No	No	No	7	4
31	5x69	5x70	alpha1a_off	100	0	No	No	Yes	No	5	5
32	5x70	I3.D224	alpha1a_off	100	0	Yes	No	No	No	5	3
33	5x71	I3.D224	alpha1a_off	100	0	No	No	No	No	4	3
34	5x71	I3.L227	alpha1a_off	100	0	No	No	No	No	4	3
35	5x72	I3.K223	alpha1a_off	100	0	No	No	No	No	6	3
36	5x74	I3.K223	alpha1a_off	100	0	No	No	No	No	4	3
37	5x76	I3.R225	alpha1a_off	100	0	No	No	No	No	2	1
38	I3.D224	I3.R228	alpha1a_off	100	0	No	No	No	No	3	1
39	I3.N226	I3.R225	alpha1a_off	100	0	No	No	No	No	1	1
40	I3.R225	I3.R229	alpha1a_off	100	0	No	No	No	No	1	3
41	6x39	7x52	alpha1a_off	100	0	No	No	No	No	7	8
42	6x39	7x56	alpha1a_off	100	0	No	No	Yes	No	7	7
43	6x43	7x52	alpha1a_off	100	0	No	No	No	No	7	8
44	6x48	6x51	alpha1a_off	100	0	Yes	Yes	Yes	Yes	8	7
45	6x54	E3.P303	alpha1a_off	100	0	No	No	No	No	5	4
46	E3.D300	E3.P299	alpha1a_off	100	0	No	No	No	No	1	2
47	7x34	Lig	alpha1a_off	100	0	No	No	Yes	Yes	4	0
48	7x38	7x39	alpha1a_off	100	0	Yes	Yes	Yes	Yes	6	6
49	7x54	8x54	alpha1a_off	100	0	No	No	Yes	No	7	7
50	8x55	8x59	alpha1a_off	100	0	No	No	No	No	5	5
51	Lig	Lig	alpha1a_off	100	0	Yes	Yes	Yes	Yes	0	0
52	E3.P299	Lig	alpha1a_off	100	0	No	No	Yes	Yes	2	0
53	E2.E180	Lig	alpha1a_off	100	0	No	No	Yes	Yes	5	0
54	5x37	Lig	alpha1a_off	100	0	No	No	Yes	Yes	4	0
55	E2.I175	Lig	alpha1a_off	100	0	No	Yes	Yes	Yes	5	0
56	E2x51	Lig	alpha1a_off	100	0	No	No	Yes	Yes	5	0
57	7x31	Lig	alpha1a_off	100	0	No	No	Yes	Yes	2	0
58	E2x52	Lig	alpha1a_off	100	0	No	No	Yes	Yes	6	0
59	E1x49	Lig	alpha1a_off	100	0	No	No	Yes	Yes	4	0
60	2x46	3x39	alpha1a_off	100	0	No	No	Yes	No	9	9
61	3x21	E2.E173	alpha1a_off	100	0	No	No	No	No	8	4
62	I2x52	I2x56	alpha1a_off	100	0	No	No	No	No	5	5
63	4x52	4x56	alpha1a_off	100	0	No	No	No	No	5	6
64	4x62	E2.Q167	alpha1a_off	100	0	No	No	No	No	4	5
65	E2.A169	E2.R166	alpha1a_off	100	0	No	No	No	No	3	5
66	E2.E180	E2x51	alpha1a_off	100	0	No	No	No	No	5	5
67	5x58	I3.G275	alpha1a_off	100	0	Yes	Yes	No	No	9	0
68	5x74	5x76	alpha1a_off	100	0	No	No	No	No	4	2
69	7x56	I3.T273	alpha1a_off	100	0	Yes	No	No	No	7	6
70	6x44	7x45	alpha1a_off	100	0	Yes	Yes	Yes	No	9	9
71	6x48	7x42	alpha1a_off	100	0	Yes	Yes	Yes	Yes	8	7
72	6x54	7x34	alpha1a_off	100	0	No	No	No	No	5	4
73	8x52	8x56	alpha1a_off	100	0	No	No	No	No	5	5
74	7x53	8x50	alpha1a_off	50	0	No	Yes	No	No	9	8
75	5x58	I3.V234	alpha1a_off	50	0	Yes	Yes	No	No	9	2
76	6x60	Lig	alpha1a_off	50	0	No	No	Yes	Yes	5	0
77	3x45	4x45	alpha1a_off	0	0	Yes	No	No	No	7	6
78	3x50	I3.L227	alpha1a_off	50	0	Yes	Yes	No	No	9	3
79	3x37	4x57	alpha1a_off	0	0	Yes	No	Yes	No	7	8
80	8x47	I3.T273	alpha1a_off	50	0	No	No	No	No	8	6
81	5x58	5x61	alpha1a_off	50	0	Yes	Yes	No	No	9	9
82	1x47	1x51	alpha1a_off	0	0	No	No	No	No	6	4
83	I2x56	I2x57	alpha1a_off	50	0	No	No	Yes	Yes	5	6
84	2x51	2x55	alpha1a_off	50	0	No	No	No	No	7	5
85	1x52	8x57	alpha1a_off	0	0	No	No	No	No	7	6
86	1x55	8x57	alpha1a_off	50	0	No	No	No	No	4	6
87	6x40	7x49	alpha1a_off	50	0	No	No	Yes	Yes	8	9
88	E2.D172	Lig	alpha1a_off	50	0	No	No	Yes	Yes	3	0
89	3x48	3x52	alpha1a_off	0	0	No	No	No	No	6	5
90	3x48	5x57	alpha1a_off	50	0	No	No	No	No	6	6
91	3x43	5x54	alpha1a_off	50	0	No	Yes	No	No	8	8
92	3x22	E2.A169	alpha1a_off	50	0	Yes	No	No	No	5	3
93	1x57	8x50	alpha1a_off	50	0	No	No	No	No	8	8
94	5x63	5x67	alpha1a_off	50	0	No	No	No	No	4	5
95	5x58	I3.T231	alpha1a_off	50	0	Yes	Yes	No	No	9	5
96	5x70	5x75	alpha1a_off	50	0	Yes	No	No	No	5	2
97	5x72	I2x50	alpha1a_off	50	0	No	No	No	No	6	8
98	7x40	7x41	alpha1a_off	0	0	No	No	No	No	7	7
99	5x70	5x73	alpha1a_off	50	0	Yes	No	No	No	5	4
100	1x31	1x32	alpha1a_off	50	0	No	No	No	No	3	4
101	6x41	6x45	alpha1a_off	0	0	No	No	No	No	8	5
102	I2x55	I2x56	alpha1a_off	0	0	No	No	No	No	4	5
103	3x47	I3.L274	alpha1a_off	0	0	No	No	No	No	9	0
104	5x72	I3.L227	alpha1a_off	0	0	No	No	No	No	6	3
105	1x38	1x42	alpha1a_off	0	0	No	No	No	No	5	7
106	2x49	3x39	alpha1a_off	0	0	No	No	Yes	No	8	9
107	3x50	I3.A270	alpha1a_off	0	0	Yes	Yes	No	No	9	0
108	5x65	I3.R228	alpha1a_off	0	0	No	No	No	No	8	1
109	3x50	I3.I230	alpha1a_off	50	0	Yes	Yes	No	No	9	4
110	4x56	5x46	alpha1a_off	0	0	No	No	No	No	6	5
111	6x57	6x58	alpha1a_off	0	0	No	No	No	No	5	4
112	7x55	7x56	alpha1a_off	0	0	No	No	Yes	No	5	7
113	1x35	1x36	alpha1a_off	0	0	No	No	No	No	5	6
114	1x40	1x44	alpha1a_off	0	0	No	No	No	No	3	4
115	5x61	I3.A271	alpha1a_off	0	0	No	No	No	No	9	0
116	7x54	8x51	alpha1a_off	0	0	No	No	No	No	7	8
117	3x29	E2x52	alpha1a_off	0	0	No	No	No	No	6	6
118	4x44	4x48	alpha1a_off	0	0	No	No	No	No	3	2
119	1x33	1x37	alpha1a_off	0	0	No	No	No	No	6	5
120	3x23	3x27	alpha1a_off	0	0	No	No	No	No	3	5
121	3x27	3x31	alpha1a_off	0	0	No	No	No	No	5	5
122	7x32	7x36	alpha1a_off	0	0	No	No	No	No	1	5
123	7x56	I3.L233	alpha1a_off	0	0	Yes	No	No	No	7	6
124	6x39	I3.K272	alpha1a_off	0	0	No	No	No	No	7	0
125	5x63	5x66	alpha1a_off	0	0	No	No	No	No	4	5
126	1x57	I1x51	alpha1a_off	0	0	No	No	No	No	8	8
127	8x55	8x58	alpha1a_off	0	0	No	No	No	No	5	7
128	1x39	7x39	Shared	100	100	No	Yes	Yes	Yes	7	6
129	1x42	7x43	Shared	100	0	No	No	No	No	7	5
130	1x43	2x57	Shared	100	100	No	No	No	No	5	8
131	1x45	7x51	Shared	100	100	No	No	No	No	5	6
132	1x46	7x47	Shared	100	100	No	No	No	No	8	6
133	1x49	7x50	Shared	100	75	No	No	No	No	9	9
134	1x50	2x50	Shared	100	100	No	Yes	Yes	Yes	9	9
135	1x50	7x50	Shared	100	100	No	Yes	No	No	9	9
136	1x51	2x51	Shared	100	100	No	No	No	No	4	7
137	1x52	8x54	Shared	100	100	No	No	Yes	No	7	7
138	1x53	2x47	Shared	100	100	No	No	No	No	9	9
139	1x56	8x54	Shared	100	25	No	No	Yes	No	8	7
140	1x57	2x44	Shared	100	100	No	No	No	No	8	6
141	1x60	I1x50	Shared	100	100	Yes	Yes	Yes	Yes	6	8
142	1x60	8x53	Shared	100	25	Yes	Yes	No	No	6	7
143	1x60	8x56	Shared	100	25	Yes	Yes	No	No	6	5
144	I1x48	I1x51	Shared	100	50	No	No	No	No	7	8
145	I1x49	I1x50	Shared	100	25	No	No	Yes	Yes	6	8
146	2x40	I1x50	Shared	100	100	No	No	Yes	Yes	8	8
147	8x49	I1x50	Shared	100	50	No	No	Yes	Yes	7	8
148	2x37	2x39	Shared	100	50	No	No	No	No	7	8
149	2x37	2x40	Shared	100	100	No	No	No	No	7	8
150	2x38	2x42	Shared	100	100	No	No	Yes	Yes	7	8
151	2x39	3x49	Shared	100	100	No	No	Yes	Yes	8	9
152	2x42	3x45	Shared	100	100	Yes	Yes	Yes	No	8	7
153	2x42	3x49	Shared	100	100	Yes	Yes	Yes	Yes	8	9
154	2x45	4x46	Shared	100	100	No	No	No	No	9	8
155	2x45	4x50	Shared	100	100	No	No	No	No	9	9
156	2x50	3x39	Shared	100	100	Yes	Yes	Yes	No	9	9
157	2x50	7x49	Shared	100	100	Yes	Yes	Yes	Yes	9	9
158	2x53	3x35	Shared	100	100	Yes	No	No	No	8	6
159	2x53	7x46	Shared	100	100	Yes	No	No	No	8	9
160	2x55	2x551	Shared	100	100	No	No	No	No	5	6
161	2x56	3x28	Shared	100	100	Yes	Yes	Yes	Yes	8	5
162	2x56	3x32	Shared	100	100	Yes	Yes	No	No	8	7
163	2x57	7x42	Shared	100	100	No	No	Yes	Yes	8	7
164	2x59	3x28	Shared	100	100	No	No	Yes	Yes	5	5
165	2x60	3x28	Shared	100	100	No	No	Yes	Yes	7	5
166	2x62	2x66	Shared	100	100	No	No	No	Yes	5	5
167	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	4	8
168	2x64	7x35	Shared	100	100	No	No	No	No	5	5
169	2x64	7x39	Shared	100	100	No	No	Yes	Yes	5	6
170	E1x50	E1x52	Shared	100	100	Yes	Yes	No	No	8	5
171	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	8
172	3x28	E1x50	Shared	100	100	Yes	Yes	Yes	Yes	5	8
173	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	8	9
174	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
175	3x32	7x42	Shared	100	100	No	No	Yes	Yes	7	7
176	3x32	Lig	Shared	100	100	No	No	Yes	Yes	7	0
177	3x33	4x57	Shared	100	100	No	No	Yes	No	6	8
178	3x34	4x57	Shared	100	100	No	No	Yes	No	6	8
179	3x36	Lig	Shared	100	100	No	No	Yes	Yes	6	0
180	3x37	3x41	Shared	100	25	Yes	No	Yes	No	7	6
181	3x37	4x53	Shared	100	100	Yes	No	No	No	7	8
182	3x37	5x461	Shared	100	100	Yes	No	No	No	7	6
183	3x38	4x50	Shared	100	100	No	No	No	No	8	9
184	3x38	4x53	Shared	100	100	No	No	No	No	8	8
185	3x40	5x50	Shared	100	100	No	No	No	No	8	9
186	3x40	6x44	Shared	100	100	No	No	Yes	Yes	8	9
187	3x41	4x52	Shared	100	100	Yes	No	No	No	6	5
188	3x43	6x44	Shared	100	100	No	Yes	Yes	Yes	8	9
189	3x44	5x53	Shared	100	100	No	No	No	No	6	6
190	3x45	4x49	Shared	100	75	Yes	No	No	No	7	6
191	3x47	5x54	Shared	100	100	No	No	No	No	9	8
192	3x48	5x53	Shared	100	0	No	No	No	No	6	6
193	3x49	I2x53	Shared	100	100	Yes	Yes	Yes	Yes	9	7
194	3x49	I2x57	Shared	100	100	Yes	Yes	Yes	Yes	9	6
195	3x51	3x55	Shared	100	100	No	No	No	No	8	7
196	3x51	5x57	Shared	100	100	No	No	No	No	8	6
197	3x52	I2x57	Shared	100	100	No	No	Yes	Yes	5	6
198	3x53	I2x53	Shared	100	100	No	No	Yes	Yes	8	7
199	3x54	5x61	Shared	100	50	No	No	No	No	8	9
200	3x55	3x56	Shared	100	100	No	No	No	No	7	6
201	I2x53	I2x54	Shared	100	100	Yes	Yes	No	No	7	6
202	I2x53	I2x57	Shared	100	100	Yes	Yes	Yes	Yes	7	6
203	4x38	4x41	Shared	100	50	No	No	No	No	7	6
204	4x40	4x44	Shared	100	25	No	No	No	No	5	3
205	4x57	4x58	Shared	100	50	Yes	No	No	No	8	4
206	4x59	4x60	Shared	100	100	No	No	Yes	No	7	7
207	4x60	5x39	Shared	100	100	Yes	No	Yes	Yes	7	8
208	4x64	5x39	Shared	100	100	No	No	Yes	Yes	6	8
209	E2.P168	E2.Q167	Shared	100	100	No	No	No	No	4	5
210	E2.I175	E2.P170	Shared	100	100	No	Yes	No	No	5	4
211	E2.D172	E2.T174	Shared	100	100	No	No	No	No	3	1
212	5x39	E2.N179	Shared	100	100	Yes	Yes	No	No	8	5
213	5x39	5x43	Shared	100	100	Yes	Yes	No	No	8	7
214	5x40	6x55	Shared	100	100	No	No	No	No	6	7
215	5x40	6x59	Shared	100	100	No	No	No	No	6	5
216	5x41	6x60	Shared	100	100	No	No	No	No	6	5
217	5x44	6x52	Shared	100	0	No	No	Yes	Yes	7	7
218	5x47	5x48	Shared	100	100	Yes	Yes	No	No	8	6
219	5x47	5x51	Shared	100	100	Yes	Yes	No	No	8	6
220	5x47	6x44	Shared	100	100	Yes	Yes	Yes	Yes	8	9
221	5x47	6x49	Shared	100	100	Yes	Yes	No	Yes	8	7
222	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
223	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
224	6x47	7x45	Shared	100	100	No	No	Yes	No	8	9
225	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
226	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
227	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	8	9
228	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	7	7
229	6x51	6x55	Shared	100	100	Yes	Yes	No	No	7	7
230	6x51	7x38	Shared	100	100	Yes	Yes	Yes	Yes	7	6
231	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
232	6x55	6x56	Shared	100	100	No	No	No	No	7	6
233	7x38	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
234	7x38	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
235	7x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
236	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
237	7x49	7x53	Shared	100	100	Yes	Yes	No	Yes	9	9
238	8x47	8x50	Shared	100	100	No	No	No	No	8	8
239	1x35	1x39	Shared	100	0	No	No	No	Yes	5	7
240	1x52	8x58	Shared	100	25	No	No	No	No	7	7
241	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
242	2x53	7x42	Shared	100	100	Yes	No	Yes	Yes	8	7
243	2x66	E1x49	Shared	100	100	No	Yes	No	No	5	4
244	3x51	5x60	Shared	100	100	No	No	No	No	8	6
245	6x49	6x53	Shared	100	100	No	Yes	No	No	7	6
246	6x61	E3.F301	Shared	100	100	No	Yes	No	Yes	4	3
247	7x43	7x48	Shared	100	25	No	No	No	No	5	6
248	6x60	6x61	Shared	50	25	No	No	No	Yes	5	4
249	E1x49	E1x51	Shared	50	25	No	No	No	No	4	3
250	7x33	E3.P303	Shared	50	25	No	No	No	No	5	4
251	3x42	3x45	Shared	50	75	No	No	Yes	No	7	7
252	6x51	7x37	Shared	50	100	Yes	Yes	No	No	7	5
253	1x56	8x53	Shared	50	25	No	No	No	No	8	7
254	1x43	2x58	Shared	50	100	No	No	No	No	5	9
255	E3.K302	E3.P303	Shared	50	100	No	No	No	No	3	4
256	6x49	6x50	Shared	50	50	No	Yes	No	No	7	9
257	7x30	7x33	Shared	50	0	No	No	No	No	5	5
258	3x22	3x26	Shared	50	25	Yes	No	No	No	5	6
259	2x56	3x31	Shared	0	50	Yes	Yes	No	No	8	5
260	1x39	2x61	Shared	0	50	No	Yes	No	No	7	6
261	5x36	5x37	Shared	0	100	No	No	No	No	6	4
262	3x22	E2.E173	Shared	50	25	Yes	No	No	No	5	4
263	1x54	2x48	Shared	0	25	No	No	No	No	7	6
264	2x54	2x57	Shared	0	100	No	No	No	No	7	8
265	2x42	4x42	Shared	0	50	Yes	Yes	No	No	8	7
266	1x51	1x55	Shared	0	0	No	No	No	No	4	4
267	1x40	1x41	Shared	0	0	No	No	No	No	3	5
268	8x48	8x51	Shared	50	25	No	No	No	No	5	8
269	3x47	5x58	Shared	50	100	No	No	Yes	Yes	9	9
270	2x66	2x67	Shared	0	0	No	Yes	No	No	5	4
271	1x32	2x65	Shared	0	0	No	No	No	No	4	5
272	1x46	1x50	Shared	0	0	No	No	No	Yes	8	9
273	3x54	5x64	Shared	0	50	No	No	No	No	8	6
274	7x30	7x32	Shared	0	100	No	No	No	No	5	1
275	2x52	3x35	Shared	0	50	No	No	No	No	6	6
276	3x30	4x61	Shared	0	25	No	No	No	No	6	5
277	1x45	1x46	Shared	0	0	No	No	No	No	5	8
278	1x59	1x60	Shared	0	100	No	No	Yes	Yes	5	6
279	7x48	7x52	Shared	0	100	No	No	No	No	6	8
280	2x38	4x39	Shared	0	25	No	No	No	No	7	4
281	5x51	5x55	Shared	0	100	No	No	No	No	6	5
282	5x56	5x60	Shared	0	100	No	No	No	No	4	6
283	5x64	5x67	Shared	0	50	No	No	No	No	6	5
284	4x38	4x40	Shared	0	0	No	No	No	No	7	5
285	6x57	6x61	Shared	0	100	No	No	No	Yes	5	4
286	I2x51	I2x52	Shared	0	50	No	No	No	No	7	5
287	1x36	2x65	Shared	0	0	No	No	No	No	6	5
288	6x41	6x42	Shared	0	0	No	No	No	No	8	5
289	1x40	1x43	Shared	0	50	No	No	No	No	3	5
290	5x45	5x46	Shared	0	25	No	No	No	No	4	5
291	4x62	4x63	Shared	0	50	No	No	No	No	4	5
292	4x43	4x47	Shared	0	0	No	No	No	No	5	4
293	4x39	4x43	Shared	0	0	No	No	No	No	4	5
294	1x50	2x51	alpha1a_on	0	100	No	Yes	No	No	9	7
295	1x53	7x54	alpha1a_on	0	100	No	No	No	No	9	7
296	1x57	I1x50	alpha1a_on	0	100	No	No	Yes	Yes	8	8
297	2x38	I2x57	alpha1a_on	0	100	No	No	Yes	Yes	7	6
298	2x40	8x50	alpha1a_on	0	100	No	No	No	No	8	8
299	2x41	4x39	alpha1a_on	0	100	No	No	No	No	5	4
300	2x43	8x50	alpha1a_on	0	100	No	No	No	No	7	8
301	2x46	2x50	alpha1a_on	0	100	No	No	Yes	Yes	9	9
302	2x46	3x43	alpha1a_on	0	100	No	No	No	Yes	9	8
303	2x46	7x49	alpha1a_on	0	100	No	No	Yes	Yes	9	9
304	2x56	7x42	alpha1a_on	0	100	Yes	Yes	Yes	Yes	8	7
305	2x59	E1x52	alpha1a_on	0	100	No	No	No	No	5	5
306	2x60	7x39	alpha1a_on	0	100	No	No	Yes	Yes	7	6
307	2x60	7x42	alpha1a_on	0	100	No	No	Yes	Yes	7	7
308	3x21	E1x50	alpha1a_on	0	100	No	No	Yes	Yes	8	8
309	3x33	Lig	alpha1a_on	0	100	No	No	Yes	Yes	6	0
310	3x36	6x48	alpha1a_on	0	100	No	No	Yes	Yes	6	8
311	3x40	6x48	alpha1a_on	0	100	No	No	Yes	Yes	8	8
312	3x41	4x49	alpha1a_on	0	100	Yes	No	No	No	6	6
313	3x43	7x49	alpha1a_on	0	100	No	Yes	Yes	Yes	8	9
314	3x43	7x53	alpha1a_on	0	100	No	Yes	No	Yes	8	9
315	3x46	3x50	alpha1a_on	0	100	No	No	Yes	Yes	9	9
316	3x46	7x53	alpha1a_on	0	100	No	No	No	Yes	9	9
317	3x47	5x57	alpha1a_on	0	100	No	No	No	No	9	6
318	3x50	5x58	alpha1a_on	0	100	Yes	Yes	Yes	Yes	9	9
319	3x50	7x53	alpha1a_on	0	100	Yes	Yes	No	Yes	9	9
320	3x50	7x56	alpha1a_on	0	100	Yes	Yes	Yes	No	9	7
321	3x56	I2x52	alpha1a_on	0	100	No	No	No	No	6	5
322	4x60	E2.N179	alpha1a_on	0	100	Yes	No	No	No	7	5
323	4x64	5x36	alpha1a_on	0	100	No	No	No	No	6	6
324	E2.Q167	E2.R166	alpha1a_on	0	100	No	No	No	No	5	5
325	E2.N179	E2.R166	alpha1a_on	0	100	No	No	No	No	5	5
326	E2.D172	E2.I175	alpha1a_on	0	100	No	No	No	Yes	3	5
327	E2.I175	E2x51	alpha1a_on	0	100	No	Yes	No	No	5	5
328	E2.E180	E2x52	alpha1a_on	0	100	No	No	No	No	5	6
329	5x43	Lig	alpha1a_on	0	100	No	No	Yes	Yes	7	0
330	5x461	6x52	alpha1a_on	0	100	No	No	Yes	Yes	6	7
331	5x47	6x48	alpha1a_on	0	100	Yes	Yes	Yes	Yes	8	8
332	5x49	5x50	alpha1a_on	0	100	No	No	No	No	5	9
333	5x54	6x44	alpha1a_on	0	100	No	No	Yes	Yes	8	9
334	5x58	6x40	alpha1a_on	0	100	Yes	Yes	No	No	9	8
335	5x58	6x41	alpha1a_on	0	100	Yes	Yes	No	No	9	8
336	5x62	5x66	alpha1a_on	0	100	No	Yes	No	No	5	5
337	5x62	6x34	alpha1a_on	0	100	No	Yes	No	No	5	0
338	5x66	6x30	alpha1a_on	0	100	No	No	No	No	5	0
339	5x67	6x29	alpha1a_on	0	100	No	No	No	No	5	0
340	6x26	6x30	alpha1a_on	0	100	No	No	No	No	0	0
341	6x48	Lig	alpha1a_on	0	100	Yes	Yes	Yes	Yes	8	0
342	6x52	Lig	alpha1a_on	0	100	Yes	Yes	Yes	Yes	7	0
343	6x54	7x37	alpha1a_on	0	100	No	No	No	No	5	5
344	6x57	E3.F301	alpha1a_on	0	100	No	No	No	Yes	5	3
345	7x30	7x31	alpha1a_on	0	100	No	No	No	No	5	2
346	7x45	7x49	alpha1a_on	0	100	Yes	No	Yes	Yes	9	9
347	7x52	7x53	alpha1a_on	0	100	No	No	No	Yes	8	9
348	5x58	6x37	alpha1a_on	0	100	Yes	Yes	No	No	9	0
349	6x59	6x60	alpha1a_on	0	100	No	No	No	No	5	5
350	E3.D300	E3.F301	alpha1a_on	0	100	No	No	No	Yes	1	3
351	6x43	7x48	alpha1a_on	0	75	No	No	No	No	7	6
352	E3.F301	E3.P303	alpha1a_on	0	25	No	Yes	No	No	3	4
353	1x47	2x54	alpha1a_on	0	50	No	No	No	No	6	7
354	2x551	2x56	alpha1a_on	0	50	No	No	Yes	Yes	6	8
355	7x38	E2x52	alpha1a_on	0	50	Yes	Yes	No	No	6	6
356	4x56	5x43	alpha1a_on	0	25	No	No	No	No	6	7
357	5x61	6x37	alpha1a_on	0	25	No	No	No	No	9	0
358	6x45	6x49	alpha1a_on	0	50	No	No	No	Yes	5	7
359	3x23	3x24	alpha1a_on	0	50	No	No	No	No	3	5
360	6x50	7x40	alpha1a_on	0	25	No	No	No	No	9	7
361	3x44	5x54	alpha1a_on	0	25	No	No	No	No	6	8
362	4x56	5x42	alpha1a_on	0	25	No	No	No	No	6	5
363	6x27	6x31	alpha1a_on	0	25	No	No	No	No	0	0
364	3x26	E2.R166	alpha1a_on	0	25	No	No	No	No	6	5
365	7x34	7x38	alpha1a_on	0	25	No	No	Yes	Yes	4	6
366	5x67	5x68	alpha1a_on	0	25	No	No	No	No	5	7
367	6x58	E3.K302	alpha1a_on	0	50	No	No	No	No	4	3
368	2x49	4x50	alpha1a_on	0	0	No	No	No	No	8	9
369	3x52	I2x56	alpha1a_on	0	50	No	No	No	No	5	5
370	5x62	6x37	alpha1a_on	0	0	No	Yes	No	No	5	0
371	I2x52	I2x55	alpha1a_on	0	0	No	No	No	No	5	4
372	4x62	4x64	alpha1a_on	0	25	No	No	No	No	4	6
373	6x32	6x36	alpha1a_on	0	25	No	No	No	No	0	0
374	1x53	7x50	alpha1a_on	0	25	No	No	No	No	9	9
375	E1x49	E2.T174	alpha1a_on	0	25	No	No	No	No	4	1
376	1x54	2x51	alpha1a_on	0	25	No	No	No	No	7	7
377	3x24	E1x52	alpha1a_on	0	25	No	No	No	No	5	5
378	4x58	4x61	alpha1a_on	0	50	No	No	No	No	4	5
379	3x22	E2.I175	alpha1a_on	0	25	Yes	No	No	Yes	5	5
380	E2.A169	E2.P170	alpha1a_on	0	0	No	No	No	No	3	4
381	I1x48	I1x50	alpha1a_on	0	25	No	No	Yes	Yes	7	8
382	6x61	E3.P299	alpha1a_on	0	0	No	Yes	No	No	4	2
383	6x31	6x35	alpha1a_on	0	25	No	No	No	No	0	0
384	5x65	6x33	alpha1a_on	0	0	No	No	No	No	8	0
385	7x36	7x40	alpha1a_on	0	25	No	No	No	No	5	7
386	4x54	4x58	alpha1a_on	0	0	No	No	No	No	4	4
387	3x26	3x27	alpha1a_on	0	25	No	No	No	No	6	5
388	5x45	5x48	alpha1a_on	0	0	No	No	No	No	4	6
389	4x48	4x52	alpha1a_on	0	0	No	No	No	No	2	5
390	8x57	8x58	alpha1a_on	0	25	No	No	No	No	6	7
391	3x56	I2x50	alpha1a_on	0	0	No	No	No	No	6	8
392	5x62	6x33	alpha1a_on	0	0	No	Yes	No	No	5	0
393	2x42	4x45	alpha1a_on	0	0	Yes	Yes	No	No	8	6
394	1x48	1x49	alpha1a_on	0	0	No	No	No	No	4	9
395	5x38	5x41	alpha1a_on	0	0	No	No	No	No	5	6
396	6x39	6x40	alpha1a_on	0	0	No	No	No	No	7	8
397	6x35	6x39	alpha1a_on	0	25	No	No	No	No	0	7
398	1x31	1x35	alpha1a_on	0	25	No	No	No	No	3	5
399	8x51	8x55	alpha1a_on	0	25	No	No	No	No	8	5
400	8x52	8x55	alpha1a_on	0	25	No	No	No	No	5	5
401	6x38	6x41	alpha1a_on	0	0	No	No	No	No	0	8
402	1x41	1x44	alpha1a_on	0	0	No	No	No	No	5	4
403	7x55	8x51	alpha1a_on	0	25	No	No	No	No	5	8
404	1x37	1x38	alpha1a_on	0	0	No	No	No	No	5	5
405	2x65	2x66	alpha1a_on	0	0	No	No	No	Yes	5	5
406	4x54	4x55	alpha1a_on	0	0	No	No	No	No	4	4
407	1x33	1x34	alpha1a_on	0	0	No	No	No	No	6	4
408	5x63	5x68	alpha1a_on	0	0	No	No	No	No	4	7
409	3x28	3x29	alpha1a_on	0	0	Yes	Yes	No	No	5	6
410	6x46	6x47	alpha1a_on	0	0	No	No	No	No	5	8
411	6x36	6x40	alpha1a_on	0	0	No	No	No	No	0	8
412	E2.E171	E2.P170	alpha1a_on	0	0	No	No	No	No	3	4
413	6x25	6x28	alpha1a_on	0	0	No	No	No	No	0	0
414	1x38	1x39	alpha1a_on	0	0	No	No	No	Yes	5	7
415	6x25	6x26	alpha1a_on	0	0	No	No	No	No	0	0
416	1x31	1x34	alpha1a_on	0	0	No	No	No	No	3	4
417	5x59	5x60	alpha1a_on	0	0	No	No	No	No	3	6
418	8x49	8x52	alpha1a_on	0	0	No	No	No	No	7	5

Orange: nodes, hubs and links specific of alpha1a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha1a_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	alpha1a_off Avg Int. Strength	alpha1a_on Avg Int. Strength	alpha1a_off Num Of Links	alpha1a_on Num Of Links	ConSurf
1	2x53	alpha1a_off	0	50	4	3	8
2	3x22	alpha1a_off	0	0	4	3	5
3	3x37	alpha1a_off	0	0	4	3	7
4	3x39	alpha1a_off	50	0	5	1	9
5	3x41	alpha1a_off	100	0	5	3	6
6	3x45	alpha1a_off	0	0	4	3	7
7	4x57	alpha1a_off	0	0	4	3	8
8	4x60	alpha1a_off	50	25	4	3	7
9	5x70	alpha1a_off	50	0	4	0	5
10	7x45	alpha1a_off	50	0	4	3	9
11	7x56	alpha1a_off	0	0	4	1	7
12	8x54	alpha1a_off	50	0	4	2	7
13	1x60	Shared	50	0	5	4	6
14	I1x50	Shared	50	75	4	6	8
15	2x42	Shared	100	50	6	5	8
16	2x50	Shared	50	100	4	5	9
17	2x56	Shared	0	50	4	5	8
18	E1x50	Shared	100	100	5	6	8
19	3x28	Shared	100	25	5	5	5
20	3x49	Shared	50	50	4	4	9
21	3x50	Shared	0	50	4	4	9
22	I2x53	Shared	100	75	4	4	7
23	I2x57	Shared	0	50	4	4	6
24	5x39	Shared	100	75	5	4	8
25	5x47	Shared	100	100	5	6	8
26	5x58	Shared	50	100	6	5	9
27	6x44	Shared	100	100	5	5	9
28	6x48	Shared	100	100	6	8	8
29	6x51	Shared	100	50	6	5	7
30	6x52	Shared	50	100	4	6	7
31	7x38	Shared	50	50	4	5	6
32	7x39	Shared	0	50	4	4	6
33	7x42	Shared	100	100	7	8	7
34	7x49	Shared	50	100	4	5	9
35	Lig	Shared	100	100	21	9	0
36	1x39	alpha1a_on	0	0	3	4	7
37	1x50	alpha1a_on	0	0	3	4	9
38	2x66	alpha1a_on	0	0	3	4	5
39	3x43	alpha1a_on	0	75	2	4	8
40	E2.I175	alpha1a_on	0	25	2	4	5
41	5x62	alpha1a_on	0	0	0	4	5
42	6x49	alpha1a_on	0	0	3	4	7
43	6x61	alpha1a_on	0	0	3	4	4
44	E3.F301	alpha1a_on	0	0	1	4	3
45	7x53	alpha1a_on	0	100	3	5	9

Orange: nodes, hubs and links specific of alpha1a_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha1a_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	alpha1a_off Recurrence	alpha1a_on Recurrence	alpha1a_off Hub1?	alpha1a_on Hub1?	alpha1a_off Hub2?	alpha1a_on Hub2?	ConSurf1	ConSurf2
1	7x53	8x50	alpha1a_off	27.6689	0	No	Yes	No	No	9	8
2	8x47	8x50	alpha1a_off	19.2164	1.71432	No	No	No	No	8	8
3	8x47	I3.T273	alpha1a_off	17.6902	0	No	No	No	No	8	6
4	7x56	I3.T273	alpha1a_off	16.4524	0	Yes	No	No	No	7	6
5	6x39	7x56	alpha1a_off	12.1139	0	No	No	Yes	No	7	7
6	6x48	7x42	alpha1a_off	59.8446	0	Yes	Yes	Yes	Yes	8	7
7	3x39	7x45	alpha1a_off	32.8286	0	Yes	No	Yes	No	9	9
8	3x39	7x49	alpha1a_off	24.4642	0	Yes	No	Yes	Yes	9	9
9	3x40	6x44	alpha1a_off	100	1.84088	No	No	Yes	Yes	8	9
10	3x40	5x50	alpha1a_off	99.4111	4.2973	No	No	No	No	8	9
11	3x41	5x50	alpha1a_off	98.8142	0	Yes	No	No	No	6	9
12	3x41	4x53	alpha1a_off	87.8861	0	Yes	No	No	No	6	8
13	3x38	4x50	alpha1a_off	88.8996	8.4853	No	No	No	No	8	9
14	2x45	4x50	alpha1a_off	88.1745	4.26279	No	No	No	No	9	9
15	2x45	4x46	alpha1a_off	87.4414	2.13427	No	No	No	No	9	8
16	2x42	4x46	alpha1a_off	86.7003	0	Yes	Yes	No	No	8	8
17	1x56	8x53	alpha1a_off	26.4351	9.37122	No	No	No	No	8	7
18	1x56	8x54	alpha1a_off	25.1893	7.26572	No	No	Yes	No	8	7
19	1x52	8x54	alpha1a_off	14.9341	5.55715	No	No	Yes	No	7	7
20	2x39	3x50	alpha1a_off	26.7396	0	No	No	Yes	Yes	8	9
21	3x28	Lig	alpha1a_off	12.2501	0	Yes	Yes	Yes	Yes	5	0
22	E2.I175	Lig	alpha1a_off	14.1009	0	No	Yes	Yes	Yes	5	0
23	E2.I175	E2.P170	alpha1a_off	12.6027	5.84479	No	Yes	No	No	5	4
24	3x22	E2.P170	alpha1a_off	10.784	0	Yes	No	No	No	5	4
25	3x49	I2x57	alpha1a_off	19.9455	6.48335	Yes	Yes	Yes	Yes	9	6
26	3x52	I2x57	alpha1a_off	13.6162	7.68567	No	No	Yes	Yes	5	6
27	3x48	3x52	alpha1a_off	12.2902	0	No	No	No	No	6	5
28	3x43	5x54	alpha1a_off	22.3531	0	No	Yes	No	No	8	8
29	5x37	Lig	alpha1a_off	28.5863	0	No	No	Yes	Yes	4	0
30	5x36	5x37	alpha1a_off	27.1562	1.95593	No	No	No	No	6	4
31	5x36	E2.N179	alpha1a_off	18.3031	0	No	No	No	No	6	5
32	6x60	Lig	alpha1a_off	10.7599	0	No	No	Yes	Yes	5	0
33	3x50	I3.L227	alpha1a_off	23.4507	0	Yes	Yes	No	No	9	3
34	5x71	I3.L227	alpha1a_off	12.2902	0	No	No	No	No	4	3
35	5x72	I3.L227	alpha1a_off	10.7119	0	No	No	No	No	6	3
36	7x34	Lig	alpha1a_off	14.177	0	No	No	Yes	Yes	4	0
37	6x54	7x34	alpha1a_off	12.6708	0	No	No	No	No	5	4
38	6x54	E3.P303	alpha1a_off	11.0764	0	No	No	No	No	5	4
39	6x44	7x45	alpha1a_off	18.7998	0	Yes	Yes	Yes	No	9	9
40	6x48	6x51	alpha1a_off	44.4338	0	Yes	Yes	Yes	Yes	8	7
41	1x39	7x39	Shared	11.7574	12.2418	No	Yes	Yes	Yes	7	6
42	7x39	7x42	Shared	10.2952	16.2227	Yes	Yes	Yes	Yes	6	7
43	2x53	7x42	Shared	15.1705	23.9257	Yes	No	Yes	Yes	8	7
44	2x53	7x46	Shared	11.9417	20.5948	Yes	No	No	No	8	9
45	2x50	7x46	Shared	11.5932	20.1116	Yes	Yes	No	No	9	9
46	7x49	7x53	Shared	30.2368	20.8192	Yes	Yes	No	Yes	9	9
47	6x48	7x45	Shared	16.228	35.2873	Yes	Yes	Yes	No	8	9
48	6x44	6x48	Shared	87.5496	69.5104	Yes	Yes	Yes	Yes	9	8
49	3x38	4x53	Shared	89.6166	10.5793	No	No	No	No	8	8
50	2x42	3x49	Shared	77.9874	60.2255	Yes	Yes	Yes	Yes	8	9
51	2x39	3x49	Shared	61.1465	49.4046	No	No	Yes	Yes	8	9
52	2x37	2x39	Shared	38.4529	47.5752	No	No	No	No	7	8
53	2x37	2x40	Shared	37.2872	45.7113	No	No	No	No	7	8
54	2x40	I1x50	Shared	36.1134	38.7275	No	No	Yes	Yes	8	8
55	1x60	I1x50	Shared	32.444	16.9016	Yes	Yes	Yes	Yes	6	8
56	1x60	8x53	Shared	27.673	11.0683	Yes	Yes	No	No	6	7
57	7x42	Lig	Shared	51.332	75.1711	Yes	Yes	Yes	Yes	7	0
58	3x43	6x44	Shared	23.6069	26.7733	No	Yes	Yes	Yes	8	9
59	3x47	5x54	Shared	17.2575	74.9698	No	No	No	No	9	8
60	3x47	5x58	Shared	14.866	52.8792	No	No	Yes	Yes	9	9
61	5x39	E2.N179	Shared	16.5084	40.6604	Yes	Yes	No	No	8	5
62	6x51	Lig	Shared	44.5459	29.2297	Yes	Yes	Yes	Yes	7	0
63	2x57	7x42	alpha1a_on	8.74494	15.1355	No	No	Yes	Yes	8	7
64	1x50	2x50	alpha1a_on	7.2307	40.2175	No	Yes	Yes	Yes	9	9
65	1x46	1x50	alpha1a_on	4.11809	10.3262	No	No	No	Yes	8	9
66	1x50	2x51	alpha1a_on	0	12.8804	No	Yes	No	No	9	7
67	1x50	7x50	alpha1a_on	2.14317	15.4231	No	Yes	No	No	9	9
68	6x52	Lig	alpha1a_on	0	49.0192	Yes	Yes	Yes	Yes	7	0
69	5x461	6x52	alpha1a_on	0	100	No	No	Yes	Yes	6	7
70	3x37	5x461	alpha1a_on	1.39406	98.5273	Yes	No	No	No	7	6
71	3x37	3x41	alpha1a_on	7.17462	87.8962	Yes	No	Yes	No	7	6
72	3x41	4x49	alpha1a_on	0	83.1675	Yes	No	No	No	6	6
73	3x45	4x49	alpha1a_on	1.39406	81.5682	Yes	No	No	No	7	6
74	2x42	3x45	alpha1a_on	5.5402	78.2143	Yes	Yes	Yes	No	8	7
75	2x38	2x42	alpha1a_on	5.5402	14.9341	No	No	Yes	Yes	7	8
76	3x37	4x53	alpha1a_on	2.4356	12.6618	Yes	No	No	No	7	8
77	6x48	Lig	alpha1a_on	0	72.9909	Yes	Yes	Yes	Yes	8	0
78	2x50	7x49	alpha1a_on	8.68886	30.2134	Yes	Yes	Yes	Yes	9	9
79	7x45	7x49	alpha1a_on	0	31.8357	Yes	No	Yes	Yes	9	9
80	2x56	7x42	alpha1a_on	0	29.5864	Yes	Yes	Yes	Yes	8	7
81	2x60	3x28	alpha1a_on	1.45816	23.7991	No	No	Yes	Yes	7	5
82	2x59	3x28	alpha1a_on	3.32893	19.0301	No	No	Yes	Yes	5	5
83	2x59	E1x52	alpha1a_on	0	14.3071	No	No	No	No	5	5
84	3x28	E1x50	alpha1a_on	6.38144	37.1915	Yes	Yes	Yes	Yes	5	8
85	E1x50	E1x52	alpha1a_on	3.12462	14.3819	Yes	Yes	No	No	8	5
86	5x43	Lig	alpha1a_on	0	58.9599	No	No	Yes	Yes	7	0
87	5x39	5x43	alpha1a_on	1.86276	54.1794	Yes	Yes	No	No	8	7
88	E2.N179	E2.R166	alpha1a_on	0	39.5674	No	No	No	No	5	5
89	3x26	E2.R166	alpha1a_on	0	34.3612	No	No	No	No	6	5
90	3x22	3x26	alpha1a_on	1.86276	31.1684	Yes	No	No	No	5	6
91	3x22	E2.I175	alpha1a_on	0	27.6017	Yes	No	No	Yes	5	5
92	E2.D172	E2.I175	alpha1a_on	0	18.4836	No	No	No	Yes	3	5
93	E2.D172	E2.T174	alpha1a_on	1.86276	16.6254	No	No	No	No	3	1
94	E1x49	E2.T174	alpha1a_on	0	14.7558	No	No	No	No	4	1
95	2x66	E1x49	alpha1a_on	5.57225	10.982	No	Yes	No	No	5	4
96	3x33	Lig	alpha1a_on	0	15.3656	No	No	Yes	Yes	6	0
97	3x33	4x57	alpha1a_on	1.39406	13.4844	No	No	Yes	No	6	8
98	5x54	6x44	alpha1a_on	0	82.4311	No	No	Yes	Yes	8	9
99	3x43	7x53	alpha1a_on	0	16.4011	No	Yes	No	Yes	8	9
100	3x47	5x57	alpha1a_on	0	27.5211	No	No	No	No	9	6
101	3x51	5x57	alpha1a_on	6.90622	25.0762	No	No	No	No	8	6
102	3x51	3x55	alpha1a_on	2.78412	15.1815	No	No	No	No	8	7
103	3x55	3x56	alpha1a_on	1.39406	12.6791	No	No	No	No	7	6
104	7x38	7x42	alpha1a_on	1.10564	11.051	Yes	Yes	Yes	Yes	6	7
105	6x51	7x38	alpha1a_on	1.43813	11.4192	Yes	Yes	Yes	Yes	7	6
106	6x51	6x55	alpha1a_on	4.72299	58.4709	Yes	Yes	No	No	7	7
107	5x40	6x55	alpha1a_on	2.37552	52.5111	No	No	No	No	6	7
108	5x40	6x59	alpha1a_on	1.18976	49.5139	No	No	No	No	6	5
109	5x47	6x48	alpha1a_on	0	10.4067	Yes	Yes	Yes	Yes	8	8
110	5x47	6x52	alpha1a_on	4.53471	39.4351	Yes	Yes	Yes	Yes	8	7
111	5x47	6x49	alpha1a_on	3.86572	15.6935	Yes	Yes	No	Yes	8	7
112	5x58	6x40	alpha1a_on	0	15.2218	Yes	Yes	No	No	9	8
113	5x58	6x37	alpha1a_on	0	34.8214	Yes	Yes	No	No	9	0
114	5x62	6x37	alpha1a_on	0	18.3973	No	Yes	No	No	5	0
115	5x61	6x37	alpha1a_on	0	15.2505	No	No	No	No	9	0
116	3x54	5x61	alpha1a_on	6.66587	12.9839	No	No	No	No	8	9
117	3x54	5x64	alpha1a_on	5.53619	11.1373	No	No	No	No	8	6
118	6x59	6x60	alpha1a_on	0	46.5052	No	No	No	No	5	5
119	6x60	6x61	alpha1a_on	7.41497	37.4101	No	No	No	Yes	5	4
120	6x61	E3.F301	alpha1a_on	1.86276	28.1597	No	Yes	No	Yes	4	3
121	E3.F301	E3.P303	alpha1a_on	0	22.0215	No	Yes	No	No	3	4
122	7x33	E3.P303	alpha1a_on	7.41497	12.6503	No	No	No	No	5	4
123	7x52	7x53	alpha1a_on	0	19.6399	No	No	No	Yes	8	9
124	7x48	7x52	alpha1a_on	6.39346	15.7338	No	No	No	No	6	8
125	3x24	E1x52	alpha1a_on	0	19.1049	No	No	No	No	5	5
126	3x50	7x53	alpha1a_on	0	13.4787	Yes	Yes	No	Yes	9	9
127	8x49	I1x50	alpha1a_on	1.39406	10.3032	No	No	Yes	Yes	7	8
128	2x56	3x28	alpha1a_on	2.52374	40.879	Yes	Yes	Yes	Yes	8	5
129	2x60	7x42	alpha1a_on	0	24.3456	No	No	Yes	Yes	7	7
130	6x48	6x52	alpha1a_on	2.41558	43.0248	Yes	Yes	Yes	Yes	8	7
131	6x51	6x52	alpha1a_on	3.34896	29.5173	Yes	Yes	Yes	Yes	7	7
132	5x47	6x44	alpha1a_on	6.32937	31.8242	Yes	Yes	Yes	Yes	8	9
133	3x32	Lig	alpha1a_on	1.41409	24.012	No	No	Yes	Yes	7	0
134	2x56	3x32	alpha1a_on	3.9178	22.7924	Yes	Yes	No	No	8	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	2x56	alpha1a_off	4.47	0	0	0	2	2
2x56	3x28	Shared	3.675	5.515	0	1	2	1
2x56	3x32	Shared	5.11	9.1275	0	1	2	1
2x57	7x42	Shared	8.205	9.9625	0	0	2	1
2x59	3x28	Shared	3.005	5.5125	0	0	2	1
2x60	3x28	Shared	3.71	4.635	0	1	2	1
2x63	E1x50	Shared	8.015	3.5075	1	0	1	2
2x63	Lig	alpha1a_off	14.47	0	1	0	1	0
2x64	7x35	Shared	10.125	7.425	1	0	1	2
2x64	7x39	Shared	5.45	4.905	1	0	1	2
2x64	Lig	alpha1a_off	9.025	0	1	0	1	0
3x28	E1x50	Shared	6.56	5.625	1	0	1	2
3x22	E2.P170	alpha1a_off	6.485	0	0	0	2	2
3x28	Lig	alpha1a_off	7.945	0	1	0	1	0
3x32	7x42	Shared	6.9	10.63	1	1	1	1
3x32	Lig	Shared	9.245	12.5075	1	1	1	0
3x33	4x57	Shared	4.04	4.0375	0	0	1	2
3x36	Lig	Shared	2.945	8.1225	0	1	1	0
3x40	6x44	Shared	8.165	3.77	0	1	2	2
E2.I175	E2.P170	Shared	6.775	4.2325	1	0	1	2
E2.D172	E2.T174	Shared	6.505	6.505	1	0	1	2
5x39	5x43	Shared	6.36	7.3125	5	4	2	1
5x41	6x60	Shared	6.09	3.35	0	0	2	1
5x44	6x52	Shared	2.77	2.77	0	0	2	1
5x47	6x44	Shared	3.22	5.0925	0	1	2	2
5x47	6x52	Shared	20.895	19.29	0	1	2	1
6x44	6x48	Shared	7.015	5.765	1	1	2	1
6x48	6x51	alpha1a_off	6.515	0	1	1	1	1
6x48	6x52	Shared	4.01	5.26	1	1	1	1
6x48	7x41	Shared	9.15	8.7925	1	1	1	2
6x48	7x45	Shared	3.39	9.8875	1	1	1	2
6x51	6x52	Shared	3.755	5.6275	1	1	1	1
6x51	6x55	Shared	4.975	4.6625	1	1	1	2
6x51	7x38	Shared	3.75	6.9675	1	1	1	1
6x51	Lig	Shared	5.775	19.86	1	1	1	0
E3.D300	E3.P299	alpha1a_off	4.025	0	0	0	2	1
7x34	Lig	alpha1a_off	11.57	0	1	0	1	0
7x38	7x39	alpha1a_off	4.51	0	1	1	1	2
7x38	7x42	Shared	6.705	7.22	1	1	1	1
7x38	Lig	Shared	23.125	14.125	1	1	1	0
7x39	7x42	Shared	3.86	9.4075	1	1	2	1
7x42	Lig	Shared	3.37	8.2175	1	1	1	0
E3.P299	Lig	alpha1a_off	6.235	0	1	0	1	0
E2.E180	Lig	alpha1a_off	7.825	0	1	0	1	0
5x37	Lig	alpha1a_off	5.05	0	1	0	1	0
E2.I175	Lig	alpha1a_off	13.455	0	1	0	1	0
E2x51	Lig	alpha1a_off	11.595	0	1	0	1	0
7x31	Lig	alpha1a_off	7.065	0	0	0	1	0
E2x52	Lig	alpha1a_off	5.09	0	1	0	1	0
E1x49	Lig	alpha1a_off	7.445	0	1	0	1	0
2x53	7x42	Shared	2.93	4.3925	0	0	2	1
2x66	E1x49	Shared	4.105	11.43	0	0	2	1
E2.E180	E2x51	alpha1a_off	3.185	0	1	0	1	1
6x44	7x45	alpha1a_off	3.02	0	1	1	2	2
6x48	7x42	alpha1a_off	5.305	0	1	1	1	1
6x54	7x34	alpha1a_off	3.275	0	0	0	2	1
6x60	6x61	Shared	2.68	3.215	1	0	1	2
E1x49	E1x51	Shared	2.67	2	1	0	1	2
6x51	7x37	Shared	2.62	4.5875	1	1	1	2
6x60	Lig	alpha1a_off	2.51	0	1	0	1	0
5x36	5x37	Shared	2.355	3.93	0	0	2	1
E2.D172	Lig	alpha1a_off	2.21	0	1	0	1	0
3x29	E2x52	alpha1a_off	0.81	0	0	0	2	1
2x56	7x42	alpha1a_on	0	3.4725	0	1	2	1
2x60	7x39	alpha1a_on	0	4.015	0	1	2	2
2x60	7x42	alpha1a_on	0	7.3125	0	1	2	1
3x33	Lig	alpha1a_on	0	11.96	0	0	1	0
3x36	6x48	alpha1a_on	0	5.875	0	1	1	1
3x40	6x48	alpha1a_on	0	12.0375	0	1	2	1
E2.D172	E2.I175	alpha1a_on	0	5.6	1	0	1	1
E2.I175	E2x51	alpha1a_on	0	3.775	1	0	1	1
E2.E180	E2x52	alpha1a_on	0	6.8325	1	0	1	1
5x43	Lig	alpha1a_on	0	6.365	0	0	1	0
5x461	6x52	alpha1a_on	0	3.3	0	0	2	1
5x47	6x48	alpha1a_on	0	4.01	0	1	2	1
6x48	Lig	alpha1a_on	0	5.8375	1	1	1	0
6x52	Lig	alpha1a_on	0	7.2875	1	1	1	0
6x54	7x37	alpha1a_on	0	6.4125	0	0	2	2
7x30	7x31	alpha1a_on	0	5.03	0	0	2	1
6x59	6x60	alpha1a_on	0	3.965	0	0	2	1
7x38	E2x52	alpha1a_on	0	3.14	1	1	1	1
4x56	5x43	alpha1a_on	0	3.0975	0	0	2	1
7x34	7x38	alpha1a_on	0	2.68	1	0	1	1
E1x49	E2.T174	alpha1a_on	0	2.1875	1	0	1	2
3x22	E2.I175	alpha1a_on	0	1.88	0	0	2	1
6x61	E3.P299	alpha1a_on	0	1.8025	0	5	2	1
3x28	3x29	alpha1a_on	0	0.65	1	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	alpha1a_off	7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
	alpha1a_on	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2

Network Difference
Value	alpha1a_off	alpha1a_on
I_min	2.765	3.3
Number of Linked Nodes	275	268
Number of Specific Nodes	28 (10.18%)	21 (7.84%)
Number of Shared Nodes	247 (89.82%)	247 (92.16%)
Number of Links	293	291
Number of Specific Links	127 (43.34%)	125 (42.96%)
Number of Shared Links	166 (56.66%)	166 (57.04%)
Number of Hubs	35	33
Number of Specific Hubs	12 (34.29%)	10 (30.30%)
Number of Shared Hubs	23 (65.71%)	23 (69.70%)
Average % Shared Neighbours (Jaccard)	41.69
Average % Shared Neighbours (Otsuka)	49.47
Average % Shared Neighbours (Overlap Coefficient)	57.49
Average % Shared Cliques (k3-6)	79.63
Graphlets Similarity	0.519046

Paths Difference
Value	alpha1a_off	alpha1a_on
Number Of Nodes in MetaPath	61	85
Specific Nodes in MetaPath	25 (40.98%)	49 (57.65%)
Shared Nodes in MetaPath	247 (89.82%)	247 (89.82%)
Number Of Links MetaPath	62	94
Specific Links in MetaPath	40 (64.52%)	72 (76.60%)
Shared Links in MetaPath	166 (56.66%)	166 (56.66%)
Number of Shortest Paths	49949	55925
Length Of Smallest Path	3	3
Average Path Length	15.1759	12.8507
Length of Longest Path	40	32
Minimum Path Strength	0.6775	0.585
Average Path Strength	5.32224	5.89699
Maximum Path Strength	15.2033	16.1838
Minimum Path Correlation	0.7	0.7025
Average Path Correlation	0.925655	0.908962
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.125	3.33333
Average % Of Corr. Nodes	45.7575	44.1168
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	40.5392	41.4719
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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