psnGPCR

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Orange: nodes, hubs and links specific of amine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of amine_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	amine_off Int. Strength	amine_on Int. Strength	amine_off Hub1?	amine_on Hub1?	amine_off Hub2?	amine_on Hub2?	ConSurf1	ConSurf2
1	1x53	7x53	amine_off	100	0	No	No	Yes	Yes	9	9
2	8x49	I1x50	amine_off	100	0	No	No	No	No	6	8
3	2x39	3x50	amine_off	100	0	No	No	Yes	No	8	9
4	2x41	4x39	amine_off	100	0	No	No	No	No	5	3
5	2x42	4x46	amine_off	100	0	Yes	Yes	No	No	8	7
6	2x43	7x53	amine_off	100	0	No	No	Yes	Yes	7	9
7	2x53	2x56	amine_off	100	0	No	No	No	No	8	7
8	2x59	3x24	amine_off	100	0	No	No	No	No	4	4
9	2x60	7x39	amine_off	100	0	Yes	No	Yes	Yes	6	6
10	3x37	4x57	amine_off	100	0	Yes	Yes	No	No	6	7
11	3x43	6x44	amine_off	100	0	No	No	Yes	Yes	8	9
12	3x44	5x54	amine_off	100	0	No	No	No	No	6	8
13	3x48	3x52	amine_off	100	0	No	No	No	No	6	5
14	3x49	3x50	amine_off	100	0	Yes	Yes	Yes	No	9	9
15	3x50	6x34	amine_off	100	0	Yes	No	No	No	9	7
16	5x48	6x56	amine_off	100	0	No	No	No	No	5	5
17	5x51	6x45	amine_off	100	0	No	No	No	No	6	5
18	5x54	6x41	amine_off	100	0	No	No	No	Yes	8	8
19	6x40	7x49	amine_off	100	0	No	No	Yes	Yes	8	9
20	6x40	7x52	amine_off	100	0	No	No	No	No	8	8
21	6x44	7x45	amine_off	100	0	Yes	Yes	Yes	No	9	9
22	6x48	6x51	amine_off	100	0	Yes	Yes	Yes	Yes	8	7
23	6x54	7x34	amine_off	100	0	No	No	Yes	No	4	4
24	6x55	7x34	amine_off	100	0	Yes	No	Yes	No	6	4
25	6x55	Lig	amine_off	100	0	Yes	No	Yes	Yes	6	0
26	E3	E3	amine_off	100	0	Yes	Yes	Yes	Yes	4	4
27	7x49	7x53	amine_off	100	0	Yes	Yes	Yes	Yes	9	9
28	7x53	8x50	amine_off	100	0	Yes	Yes	Yes	Yes	9	8
29	7x54	8x54	amine_off	100	0	No	No	No	Yes	6	7
30	3x41	5x50	amine_off	100	0	No	No	No	No	6	9
31	5x58	6x38	amine_off	100	0	Yes	Yes	No	No	9	5
32	Lig	Lig	amine_off	100	0	Yes	Yes	Yes	Yes	0	0
33	NT	NT	amine_off	100	0	Yes	No	Yes	No	0	0
34	2x60	7x38	amine_off	100	0	Yes	No	Yes	No	6	6
35	1x46	2x54	amine_off	67.1667	0	No	No	No	No	7	7
36	3x50	6x37	amine_off	57.5556	0	Yes	No	No	No	9	8
37	7x34	E3	amine_off	30	0	Yes	No	Yes	Yes	4	4
38	7x55	7x56	amine_off	34.4444	0	No	No	No	No	7	0
39	2x64	7x39	amine_off	65	0	No	No	Yes	Yes	5	6
40	3x38	4x53	amine_off	56	0	No	No	No	No	7	8
41	E1x49	E2	amine_off	57.7778	0	No	No	Yes	Yes	3	3
42	3x50	6x33	amine_off	66.2963	0	Yes	No	No	No	9	8
43	1x57	2x40	amine_off	45.5	0	No	No	No	No	7	9
44	6x39	7x56	amine_off	46.9444	0	No	No	No	No	7	0
45	1x54	2x47	amine_off	41.5476	0	No	No	No	No	7	8
46	5x41	5x45	amine_off	34.4444	0	No	No	No	No	5	4
47	1x56	8x53	amine_off	32.9167	0	No	No	No	No	7	7
48	2x62	2x66	amine_off	34.9907	0	No	No	No	No	4	4
49	5x58	5x62	amine_off	52.5	0	Yes	Yes	No	Yes	9	6
50	5x41	6x59	amine_off	32.2222	0	No	No	No	No	5	5
51	5x65	6x31	amine_off	46.2222	0	No	No	Yes	No	8	5
52	3x33	4x61	amine_off	50.3333	0	No	No	No	No	6	6
53	3x50	6x30	amine_off	54.1667	0	Yes	No	No	No	9	7
54	5x36	5x37	amine_off	48.8889	0	Yes	No	No	No	5	5
55	8x51	8x55	amine_off	41	0	No	No	No	No	8	4
56	5x66	6x31	amine_off	44	0	No	No	Yes	No	5	5
57	7x33	7x37	amine_off	42.2222	0	No	No	No	No	4	5
58	4x52	4x56	amine_off	33	0	No	No	No	No	4	5
59	6x59	6x60	amine_off	35.8333	0	No	No	No	No	5	5
60	7x31	7x35	amine_off	47.2222	0	No	No	No	No	3	4
61	5x63	5x67	amine_off	27.9167	0	No	No	No	No	4	4
62	1x42	2x57	amine_off	19.2778	0	No	No	Yes	Yes	6	7
63	6x29	6x30	amine_off	32	0	No	No	No	No	6	7
64	5x51	5x55	amine_off	30.5556	0	No	No	No	No	6	5
65	6x43	7x45	amine_off	21.4286	0	No	No	Yes	No	6	9
66	6x26	6x29	amine_off	29	0	No	No	No	No	0	6
67	1x42	7x43	amine_off	16.0238	0	No	No	No	No	6	4
68	I2x50	I2x51	amine_off	41.3333	0	No	No	No	No	8	6
69	1x52	8x57	amine_off	10.9841	0	No	No	No	No	6	6
70	5x69	6x31	amine_off	30	0	No	No	Yes	No	5	5
71	1x49	7x51	amine_off	40	0	No	No	No	No	8	6
72	1x55	1x59	amine_off	14.6667	0	No	No	No	No	4	5
73	6x29	6x32	amine_off	26.3333	0	No	No	No	No	6	8
74	5x68	6x31	amine_off	29.4365	0	No	No	Yes	No	7	5
75	8x52	8x56	amine_off	14.1667	0	No	No	No	No	4	4
76	6x27	6x30	amine_off	15.6667	0	No	No	No	No	0	7
77	I2x54	I2x56	amine_off	25	0	No	No	Yes	No	5	5
78	3x21	3x23	amine_off	22.2222	0	No	No	No	No	7	2
79	1x31	1x35	amine_off	21.3333	0	No	Yes	Yes	No	3	4
80	6x28	6x31	amine_off	21.0556	0	No	No	Yes	No	0	5
81	8x55	CT	amine_off	20	0	No	No	No	No	4	0
82	2x41	4x43	amine_off	18.8889	0	No	No	No	No	5	4
83	1x58	2x44	amine_off	24.3704	0	No	No	No	No	2	5
84	1x40	2x61	amine_off	22.2222	0	No	No	No	No	4	6
85	2x67	NT	amine_off	20	0	No	No	Yes	No	4	0
86	1x32	NT	amine_off	20	0	No	No	Yes	No	5	0
87	4x64	4x67	amine_off	20	0	No	No	No	No	5	0
88	8x59	CT	amine_off	7.55556	0	No	No	No	No	3	0
89	7x35	E1	amine_off	20	0	No	No	No	No	4	0
90	6x42	6x46	amine_off	12	0	No	No	No	No	5	5
91	1x34	1x35	amine_off	8.88889	0	No	No	Yes	No	4	4
92	5x68	6x25	amine_off	20	0	No	No	No	No	7	0
93	4x52	4x55	amine_off	2.22222	0	No	No	No	No	4	4
94	4x43	4x47	amine_off	7.5	0	No	No	No	No	4	4
95	1x33	NT	amine_off	6.66667	0	No	No	Yes	No	5	0
96	4x40	4x44	amine_off	3.83333	0	No	No	No	No	5	3
97	5x69	6x24	amine_off	4	0	No	No	No	No	5	0
98	1x27	NT	amine_off	4	0	No	No	Yes	No	0	0
99	1x28	1x29	amine_off	6.66667	0	No	No	No	No	0	0
100	1x28	1x30	amine_off	4.19048	0	No	No	No	No	0	2
101	5x58	I3	amine_off	5	0	Yes	Yes	Yes	No	9	0
102	4x36	4x40	amine_off	6.66667	0	No	No	No	No	0	5
103	I2	I2x56	amine_off	6.66667	0	No	No	Yes	No	0	5
104	4x69	E2	amine_off	4	0	No	No	Yes	Yes	0	3
105	5x72	I3	amine_off	5	0	No	No	Yes	No	0	0
106	7x27	E2	amine_off	6.66667	0	No	No	Yes	Yes	0	3
107	6x58	6x62	amine_off	5	0	No	No	No	No	4	0
108	8x60	CT	amine_off	4.44444	0	No	No	No	No	7	0
109	7x29	7x33	amine_off	2.22222	0	No	No	No	No	0	4
110	5x74	I3	amine_off	2.5	0	No	No	Yes	No	0	0
111	4x34	4x38	amine_off	2.22222	0	No	No	No	Yes	0	8
112	8x59	8x61	amine_off	0	0	No	No	No	No	3	0
113	4x35	4x39	amine_off	2.22222	0	No	No	No	No	0	3
114	5x70	5x75	amine_off	1.25	0	No	No	No	No	0	0
115	5x70	5x73	amine_off	1.25	0	No	No	No	No	0	0
116	1x41	1x411	amine_off	0	0	No	No	No	No	4	0
117	1x39	2x61	Shared	100	100	No	No	No	No	6	6
118	1x39	7x39	Shared	100	100	No	No	Yes	Yes	6	6
119	1x43	2x57	Shared	100	100	No	No	Yes	Yes	5	7
120	1x43	2x58	Shared	100	42.4158	No	No	No	No	5	9
121	1x46	2x57	Shared	100	73.4722	No	No	Yes	Yes	7	7
122	1x46	7x47	Shared	100	100	No	No	No	No	7	6
123	1x49	7x50	Shared	100	39.6759	No	No	No	No	8	9
124	1x50	2x50	Shared	100	100	No	Yes	Yes	Yes	9	9
125	1x50	7x50	Shared	100	100	No	Yes	No	No	9	9
126	1x52	8x54	Shared	100	100	No	No	No	Yes	6	7
127	1x57	2x44	Shared	100	100	No	No	No	No	7	5
128	1x60	I1x49	Shared	100	100	Yes	Yes	No	No	6	5
129	1x60	I1x50	Shared	100	100	Yes	Yes	No	No	6	8
130	I1x48	I1x51	Shared	100	100	No	No	No	No	6	7
131	8x50	I1x50	Shared	100	100	Yes	Yes	No	No	8	8
132	2x37	2x40	Shared	100	100	No	No	No	No	7	9
133	2x38	I2x57	Shared	100	100	No	No	No	No	6	6
134	2x40	8x50	Shared	100	100	No	No	Yes	Yes	9	8
135	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	5
136	2x42	3x46	Shared	100	63.6785	Yes	Yes	No	Yes	8	9
137	2x42	3x49	Shared	100	100	Yes	Yes	Yes	Yes	8	9
138	2x45	3x42	Shared	100	100	No	No	No	No	9	8
139	2x45	4x46	Shared	100	100	No	No	No	No	9	7
140	2x45	4x50	Shared	100	100	No	No	No	No	9	9
141	2x46	3x42	Shared	100	100	No	Yes	No	No	9	8
142	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
143	2x50	7x49	Shared	100	100	Yes	Yes	Yes	Yes	9	9
144	2x52	3x35	Shared	100	100	No	No	No	No	6	6
145	2x53	7x46	Shared	100	100	No	No	No	No	8	9
146	2x551	3x31	Shared	100	53.2513	No	No	No	No	4	5
147	2x56	3x32	Shared	100	100	No	No	No	No	7	7
148	2x56	7x42	Shared	100	100	No	No	Yes	Yes	7	7
149	2x57	7x39	Shared	100	100	Yes	Yes	Yes	Yes	7	6
150	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	7
151	2x59	3x28	Shared	100	100	No	No	No	No	4	6
152	2x60	3x28	Shared	100	100	Yes	No	No	No	6	6
153	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	5	7
154	2x64	7x35	Shared	100	100	No	No	No	No	5	4
155	E1x50	E1x52	Shared	100	100	Yes	Yes	No	Yes	7	5
156	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	7
157	3x28	E1x50	Shared	100	100	No	No	Yes	Yes	6	7
158	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	7	9
159	3x22	E2	Shared	100	100	No	No	Yes	Yes	4	3
160	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
161	3x26	E2	Shared	100	100	No	No	Yes	Yes	6	3
162	3x29	E2x52	Shared	100	68.8026	No	No	No	No	6	4
163	3x32	7x42	Shared	100	100	No	No	Yes	Yes	7	7
164	3x32	Lig	Shared	100	100	No	No	Yes	Yes	7	0
165	3x33	4x57	Shared	100	100	No	No	No	No	6	7
166	3x33	Lig	Shared	100	100	No	No	Yes	Yes	6	0
167	3x34	4x54	Shared	100	42.3611	No	No	No	No	5	3
168	3x36	6x48	Shared	100	100	No	No	Yes	Yes	6	8
169	3x36	Lig	Shared	100	100	No	No	Yes	Yes	6	0
170	3x37	3x41	Shared	100	36.7003	Yes	Yes	No	No	6	6
171	3x37	4x53	Shared	100	100	Yes	Yes	No	No	6	8
172	3x37	5x461	Shared	100	100	Yes	Yes	No	No	6	6
173	3x38	4x50	Shared	100	100	No	No	No	No	7	9
174	3x40	5x50	Shared	100	51.5678	No	No	No	No	8	9
175	3x40	6x44	Shared	100	100	No	No	Yes	Yes	8	9
176	3x41	4x52	Shared	100	41.7929	No	No	No	No	6	4
177	3x42	4x49	Shared	100	100	No	No	No	No	8	6
178	3x45	4x45	Shared	100	100	No	No	No	No	5	6
179	3x47	5x54	Shared	100	100	No	No	No	No	8	8
180	3x47	5x57	Shared	100	100	No	No	No	No	8	6
181	3x48	5x57	Shared	100	100	No	No	No	No	6	6
182	3x49	I2x53	Shared	100	100	Yes	Yes	Yes	Yes	9	7
183	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	7
184	3x51	5x57	Shared	100	100	Yes	Yes	No	No	8	6
185	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	5
186	3x52	I2x53	Shared	100	100	No	No	Yes	Yes	5	7
187	3x56	I2x52	Shared	100	100	No	No	No	No	6	5
188	I2x53	I2x57	Shared	100	100	Yes	Yes	No	No	7	6
189	4x64	E2	Shared	100	100	No	No	Yes	Yes	5	3
190	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
191	E2	E2x52	Shared	100	100	Yes	Yes	No	No	3	4
192	5x39	E2	Shared	100	100	Yes	Yes	Yes	Yes	7	3
193	5x36	E2	Shared	100	100	Yes	No	Yes	Yes	5	3
194	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	5
195	E2x52	Lig	Shared	100	100	No	No	Yes	Yes	4	0
196	5x36	5x38	Shared	100	57.5442	Yes	No	No	No	5	4
197	5x36	5x39	Shared	100	100	Yes	No	Yes	Yes	5	7
198	5x39	5x43	Shared	100	100	Yes	Yes	No	No	7	6
199	5x43	Lig	Shared	100	100	No	No	Yes	Yes	6	0
200	5x461	Lig	Shared	100	100	No	No	Yes	Yes	6	0
201	5x47	5x48	Shared	100	100	No	Yes	No	No	7	5
202	5x47	5x51	Shared	100	100	No	Yes	No	No	7	6
203	5x47	6x52	Shared	100	100	No	Yes	Yes	Yes	7	7
204	5x58	6x41	Shared	100	100	Yes	Yes	No	Yes	9	8
205	5x62	5x66	Shared	100	100	No	Yes	No	No	6	5
206	6x39	7x52	Shared	100	26.7361	No	No	No	No	7	8
207	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
208	6x47	7x45	Shared	100	100	No	No	Yes	No	8	9
209	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
210	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	6
211	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	8	9
212	6x48	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
213	6x50	7x37	Shared	100	100	No	No	No	No	9	5
214	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	7	7
215	6x51	6x55	Shared	100	100	Yes	Yes	Yes	No	7	6
216	6x51	7x34	Shared	100	67.7083	Yes	Yes	Yes	No	7	4
217	6x51	7x38	Shared	100	100	Yes	Yes	Yes	No	7	6
218	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
219	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
220	6x54	7x37	Shared	100	100	No	No	No	No	4	5
221	6x61	E3	Shared	100	100	No	No	Yes	Yes	4	4
222	7x30	7x33	Shared	100	53.4259	No	Yes	No	No	5	4
223	7x38	7x42	Shared	100	100	Yes	No	Yes	Yes	6	7
224	7x38	Lig	Shared	100	100	Yes	No	Yes	Yes	6	0
225	7x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
226	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
227	8x47	8x49	Shared	100	100	No	No	No	No	8	6
228	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	8
229	8x48	8x52	Shared	100	19.4444	No	No	No	No	6	4
230	8x50	8x54	Shared	100	57.0707	Yes	Yes	No	Yes	8	7
231	1x60	8x53	Shared	100	65.3093	Yes	Yes	No	No	6	7
232	2x50	3x39	Shared	100	100	Yes	Yes	No	No	9	9
233	6x58	E3	Shared	100	100	No	No	Yes	Yes	4	4
234	3x49	I2x57	Shared	100	100	Yes	Yes	No	No	9	6
235	5x40	6x55	Shared	100	100	No	No	Yes	No	6	6
236	7x45	7x49	Shared	100	100	Yes	No	Yes	Yes	9	9
237	2x60	7x42	Shared	100	100	Yes	No	Yes	Yes	6	7
238	6x36	7x56	Shared	100	100	No	No	No	No	8	0
239	4x65	E2	Shared	100	19.4444	No	No	Yes	Yes	0	3
240	3x44	5x53	Shared	55.5556	100	No	No	No	No	6	6
241	3x30	4x62	Shared	56	31.4078	No	No	No	No	6	4
242	1x53	2x47	Shared	52.0661	100	No	No	No	No	9	8
243	2x55	2x551	Shared	50.0926	33.0177	No	No	No	No	5	4
244	3x30	4x61	Shared	65.7037	53.3333	No	No	No	No	6	6
245	6x57	E3	Shared	58.3333	32.037	No	No	Yes	Yes	5	4
246	5x49	5x50	Shared	59.1667	100	No	No	No	No	5	9
247	3x55	3x56	Shared	60	42.8346	No	No	No	No	7	6
248	3x51	5x61	Shared	56.1667	48.2639	Yes	Yes	No	No	8	9
249	6x49	6x53	Shared	53.8889	48.5017	No	Yes	No	No	7	6
250	6x49	6x50	Shared	51.0556	46.8161	No	Yes	No	No	7	9
251	1x51	2x51	Shared	58.6667	40.9722	No	No	No	No	3	7
252	2x42	4x42	Shared	49.6667	53.3796	Yes	Yes	No	No	8	7
253	7x43	7x48	Shared	53.3333	26.9676	No	No	No	No	4	6
254	3x34	4x57	Shared	60	50	No	No	No	No	5	7
255	2x53	3x35	Shared	45.1111	100	No	No	No	No	8	6
256	8x48	8x51	Shared	71.6667	18.1671	No	No	No	No	6	8
257	5x44	6x52	Shared	53.3333	100	No	No	Yes	Yes	6	7
258	3x54	5x64	Shared	36.6667	33.1439	No	No	No	No	9	6
259	5x64	5x67	Shared	63.3333	22.138	No	No	No	No	6	4
260	1x50	2x51	Shared	42.2222	100	No	Yes	No	No	9	7
261	2x62	E1x52	Shared	57.8889	33.0177	No	No	No	Yes	4	5
262	2x49	4x50	Shared	20	100	No	No	No	No	8	9
263	4x63	E2	Shared	45	56.0606	No	No	Yes	Yes	5	3
264	4x60	5x39	Shared	50	100	No	No	Yes	Yes	7	7
265	4x41	I2x56	Shared	46.6667	26.0417	No	No	Yes	No	7	5
266	6x50	7x40	Shared	55	16.5278	No	No	No	No	9	7
267	4x59	4x60	Shared	57.381	58.3333	No	No	No	No	6	7
268	3x30	4x58	Shared	40	100	No	No	No	No	6	5
269	4x38	4x41	Shared	51.6667	47.2222	No	Yes	No	No	8	7
270	3x53	I2x53	Shared	46.6667	100	No	No	Yes	Yes	8	7
271	1x54	2x48	Shared	41.3333	37.8472	No	No	No	No	7	5
272	1x47	2x55	Shared	33.8333	23.6322	No	No	No	No	6	5
273	3x27	3x31	Shared	25	34.8611	No	No	No	No	4	5
274	E1x49	E1x51	Shared	48	39.5833	No	No	No	No	3	4
275	1x47	2x51	Shared	30.5317	32.5231	No	No	No	No	6	7
276	1x55	8x57	Shared	41.8056	33.9815	No	No	No	No	4	6
277	5x45	5x48	Shared	46.9286	100	No	No	No	No	4	5
278	3x54	5x61	Shared	35.418	100	No	No	No	No	9	9
279	5x56	5x60	Shared	42	100	No	No	No	No	5	5
280	1x45	7x47	Shared	12.7222	36.048	No	No	No	No	5	6
281	7x30	7x32	Shared	33.8889	29.4192	No	Yes	No	No	5	3
282	5x59	5x63	Shared	40	39.4444	No	No	No	No	2	4
283	2x38	4x39	Shared	29.6667	39.7159	No	No	No	No	6	3
284	2x41	I1x51	Shared	46.9762	29.6296	No	No	No	No	5	7
285	1x36	2x65	Shared	27.037	21.5278	No	No	No	No	5	5
286	1x32	2x65	Shared	32.381	15.1957	No	No	No	No	5	5
287	4x38	4x40	Shared	15.6667	37.197	No	Yes	No	No	8	5
288	4x65	4x66	Shared	20	16.6667	No	No	No	No	0	0
289	3x56	I2x50	Shared	13.0952	24.3813	No	No	No	No	6	8
290	I2x52	I2x56	Shared	31.6667	47.2306	No	No	Yes	No	5	5
291	3x23	3x27	Shared	26.4286	4.81481	No	No	No	No	2	4
292	6x35	6x39	Shared	23.0952	24.6486	No	No	No	No	7	7
293	4x68	E2	Shared	26.6667	7.98611	No	No	Yes	Yes	0	3
294	1x48	1x49	Shared	6.66667	10.2168	No	No	No	No	4	8
295	4x56	5x46	Shared	26.8519	25.463	No	No	No	No	5	4
296	1x52	8x58	Shared	19.537	18.6111	No	No	No	No	6	6
297	5x42	5x46	Shared	20	7.32323	No	No	No	No	4	4
298	1x60	8x56	Shared	25.8333	24.5013	Yes	Yes	No	No	6	4
299	1x35	2x65	Shared	8	15.0694	Yes	No	No	No	4	5
300	1x35	1x39	Shared	12.9167	11.1322	Yes	No	No	No	4	6
301	I2x55	I2x56	Shared	11.6667	11.8981	No	No	Yes	No	5	5
302	7x36	7x40	Shared	7.5	34.3013	No	No	No	No	5	7
303	1x34	1x38	Shared	20	9.14352	No	No	No	No	4	5
304	4x44	4x48	Shared	8.44444	4.76641	No	No	No	No	3	3
305	4x47	4x51	Shared	5.71429	17.3611	No	No	No	No	4	4
306	1x28	1x31	Shared	20.7407	4.72222	No	No	No	Yes	0	3
307	1x41	1x45	Shared	6.22222	10.08	No	No	No	No	4	5
308	6x41	6x42	Shared	0	2.08333	No	Yes	No	No	8	5
309	5x66	5x70	Shared	9.16667	19.4444	No	No	No	No	5	0
310	5x67	5x71	Shared	6.66667	12.6136	No	No	No	No	4	0
311	1x33	1x37	Shared	3.55556	0.694444	No	No	No	No	5	4
312	5x52	5x56	Shared	0	6.25	No	No	No	No	3	5
313	1x44	1x48	Shared	4.71429	14.2361	No	No	No	No	5	4
314	7x26	7x29	Shared	6.66667	2.77778	No	No	No	No	0	0
315	7x26	7x28	Shared	6.66667	2.77778	No	No	No	No	0	0
316	5x76	I3	Shared	5	5.55556	No	No	Yes	No	0	0
317	4x34	4x37	Shared	6.66667	4.16667	No	No	No	No	0	0
318	2x40	I1x50	amine_on	0	100	No	No	No	No	9	8
319	2x39	3x49	amine_on	0	100	No	No	Yes	Yes	8	9
320	2x46	2x50	amine_on	0	100	No	Yes	Yes	Yes	9	9
321	2x46	3x43	amine_on	0	100	No	Yes	No	No	9	8
322	2x46	7x49	amine_on	0	100	No	Yes	Yes	Yes	9	9
323	3x24	E1x52	amine_on	0	100	No	No	No	Yes	4	5
324	3x40	6x48	amine_on	0	100	No	No	Yes	Yes	8	8
325	3x43	7x49	amine_on	0	100	No	No	Yes	Yes	8	9
326	3x43	7x53	amine_on	0	100	No	No	Yes	Yes	8	9
327	3x46	3x50	amine_on	0	100	No	Yes	Yes	No	9	9
328	3x46	7x53	amine_on	0	100	No	Yes	Yes	Yes	9	9
329	3x47	5x58	amine_on	0	100	No	No	Yes	Yes	8	9
330	3x50	5x58	amine_on	0	100	Yes	No	Yes	Yes	9	9
331	3x50	7x53	amine_on	0	100	Yes	No	Yes	Yes	9	9
332	5x40	E2	amine_on	0	100	No	No	Yes	Yes	6	3
333	5x37	6x60	amine_on	0	100	No	No	No	No	5	5
334	5x44	6x56	amine_on	0	100	No	No	No	No	6	5
335	5x47	6x44	amine_on	0	100	No	Yes	Yes	Yes	7	9
336	5x47	6x48	amine_on	0	100	No	Yes	Yes	Yes	7	8
337	5x47	6x49	amine_on	0	100	No	Yes	No	Yes	7	7
338	5x51	6x44	amine_on	0	100	No	No	Yes	Yes	6	9
339	5x54	6x44	amine_on	0	100	No	No	Yes	Yes	8	9
340	5x58	6x37	amine_on	0	100	Yes	Yes	No	No	9	8
341	5x58	6x40	amine_on	0	100	Yes	Yes	No	No	9	8
342	5x62	6x34	amine_on	0	100	No	Yes	No	No	6	7
343	5x66	6x30	amine_on	0	100	No	No	No	No	5	7
344	6x40	7x53	amine_on	0	100	No	No	Yes	Yes	8	9
345	7x52	7x53	amine_on	0	100	No	No	Yes	Yes	8	9
346	7x54	8x50	amine_on	0	100	No	No	Yes	Yes	6	8
347	4x61	E2	amine_on	0	56.0396	No	No	Yes	Yes	6	3
348	E2	E3	amine_on	0	27.9167	Yes	Yes	Yes	Yes	3	4
349	5x55	6x41	amine_on	0	67.5926	No	No	No	Yes	5	8
350	1x53	7x54	amine_on	0	62.3106	No	No	No	No	9	6
351	2x54	2x57	amine_on	0	67.3611	No	No	Yes	Yes	7	7
352	3x44	5x50	amine_on	0	58.3649	No	No	No	No	6	9
353	2x60	2x64	amine_on	0	41.6667	Yes	No	No	No	6	5
354	1x54	2x44	amine_on	0	44.5139	No	No	No	No	7	5
355	5x40	6x59	amine_on	0	51.1111	No	No	No	No	6	5
356	6x45	6x49	amine_on	0	50.1368	No	No	No	Yes	5	7
357	2x66	E1x51	amine_on	0	38.4028	No	No	No	No	4	4
358	5x37	6x59	amine_on	0	56.5025	No	No	No	No	5	5
359	1x56	8x54	amine_on	0	35.4377	No	No	No	Yes	7	7
360	6x43	7x52	amine_on	0	44.1035	No	No	No	No	6	8
361	5x65	6x33	amine_on	0	43.6574	No	No	No	No	8	8
362	1x59	8x57	amine_on	0	47.4747	No	No	No	No	5	6
363	E1x51	E1x52	amine_on	0	34.6633	No	No	No	Yes	4	5
364	1x59	1x60	amine_on	0	36.6667	No	No	Yes	Yes	5	6
365	5x62	6x37	amine_on	0	30.3346	No	Yes	No	No	6	8
366	1x50	2x47	amine_on	0	33.205	No	Yes	No	No	9	8
367	1x57	8x50	amine_on	0	35.3009	No	No	Yes	Yes	7	8
368	7x55	8x54	amine_on	0	38.9815	No	No	No	Yes	7	7
369	7x30	E3	amine_on	0	39.0046	No	Yes	Yes	Yes	5	4
370	6x43	7x48	amine_on	0	23.447	No	No	No	No	6	6
371	5x41	6x56	amine_on	0	19.9074	No	No	No	No	5	5
372	2x43	3x46	amine_on	0	26.2837	No	No	No	Yes	7	9
373	3x37	4x56	amine_on	0	32.9861	Yes	Yes	No	No	6	5
374	1x42	7x39	amine_on	0	39.0341	No	No	Yes	Yes	6	6
375	2x41	4x42	amine_on	0	25.0926	No	No	No	No	5	7
376	8x52	8x55	amine_on	0	23.8531	No	No	No	No	4	4
377	7x51	7x55	amine_on	0	27.9588	No	No	No	No	6	7
378	E1	E1x50	amine_on	0	16.6667	No	No	Yes	Yes	0	7
379	7x30	7x31	amine_on	0	25.5556	No	Yes	No	No	5	3
380	5x69	6x30	amine_on	0	27.4411	No	No	No	No	5	7
381	8x47	8x48	amine_on	0	28.4596	No	No	No	No	8	6
382	5x67	6x29	amine_on	0	21.875	No	No	No	No	4	6
383	I2x53	I2x54	amine_on	0	25	Yes	Yes	No	No	7	5
384	5x68	6x30	amine_on	0	23.6111	No	No	No	No	7	7
385	6x36	6x40	amine_on	0	9.30556	No	No	No	No	8	8
386	1x54	1x58	amine_on	0	17.5694	No	No	No	No	7	2
387	5x62	6x33	amine_on	0	6.71296	No	Yes	No	No	6	8
388	1x38	1x42	amine_on	0	18.0976	No	No	No	No	5	6
389	3x21	E1x50	amine_on	0	6.94444	No	No	Yes	Yes	7	7
390	4x48	4x52	amine_on	0	7.15278	No	No	No	No	3	4
391	5x70	5x74	amine_on	0	19.9074	No	No	No	No	0	0
392	1x30	1x31	amine_on	0	22.7168	No	No	No	Yes	2	3
393	4x51	4x55	amine_on	0	3.125	No	No	No	No	4	4
394	6x31	6x34	amine_on	0	21.5278	Yes	No	No	No	5	7
395	4x39	4x43	amine_on	0	10.7744	No	No	No	No	3	4
396	1x37	1x41	amine_on	0	13.1944	No	No	No	No	4	4
397	1x40	1x43	amine_on	0	8.68056	No	No	No	No	4	5
398	1x29	1x32	amine_on	0	19.4444	No	No	No	No	0	5
399	5x62	5x63	amine_on	0	5.68182	No	Yes	No	No	6	4
400	1x29	1x31	amine_on	0	12.5	No	No	No	Yes	0	3
401	1x30	NT	amine_on	0	9.17508	No	No	Yes	No	2	0
402	6x32	6x36	amine_on	0	7.29167	No	No	No	No	8	8
403	I2x51	I2x52	amine_on	0	5.06944	No	No	No	No	6	5
404	6x27	6x31	amine_on	0	7.98611	No	No	Yes	No	0	5
405	6x45	6x46	amine_on	0	8.33333	No	No	No	No	5	5
406	5x68	5x72	amine_on	0	6.80556	No	No	No	No	7	0
407	6x38	6x41	amine_on	0	8.33333	No	No	No	Yes	5	8
408	4x54	4x55	amine_on	0	6.94444	No	No	No	No	3	4
409	6x26	6x27	amine_on	0	2.89352	No	No	No	No	0	0
410	6x27	6x28	amine_on	0	8.33333	No	No	No	No	0	0
411	5x73	5x77	amine_on	0	4.75589	No	No	No	No	0	0
412	1x60	CT	amine_on	0	4.16667	Yes	Yes	No	No	6	0
413	2x66	2x67	amine_on	0	2.29167	No	No	No	No	4	4
414	5x74	5x75	amine_on	0	5.55556	No	No	No	No	0	0
415	6x25	6x29	amine_on	0	9.44444	No	No	No	No	0	6
416	5x72	5x76	amine_on	0	1.62037	No	No	No	No	0	0
417	4x40	I2	amine_on	0	4.16667	No	No	No	No	5	0
418	8x58	8x59	amine_on	0	4.51389	No	No	No	No	6	3
419	5x73	I3	amine_on	0	6.11111	No	No	Yes	No	0	0
420	8x61	8x62	amine_on	0	2.77778	No	No	No	No	0	0
421	4x67	4x68	amine_on	0	4.16667	No	No	No	No	0	0
422	7x28	7x32	amine_on	0	2.77778	No	No	No	No	0	3
423	7x27	E3	amine_on	0	2.77778	No	No	Yes	Yes	0	4
424	4x38	I2x58	amine_on	0	0	No	Yes	No	No	8	0
425	8x56	8x60	amine_on	0	2.77778	No	No	No	No	4	7
426	4x68	4x69	amine_on	0	0	No	No	No	No	0	0
427	5x77	5x78	amine_on	0	1.51515	No	No	No	No	0	0
428	5x79	5x80	amine_on	0	1.51515	No	No	No	No	0	0
429	5x78	5x79	amine_on	0	0	No	No	No	No	0	0
430	5x77	5x81	amine_on	0	0.462963	No	No	No	No	0	0
431	6x24	6x26	amine_on	0	1.38889	No	No	No	No	0	0
432	2x67	2x68	amine_on	0	0	No	No	No	No	4	0
433	2x37	I1x52	amine_on	0	0.462963	No	No	No	No	7	0
434	1x26	1x31	amine_on	0	1.04167	No	No	No	Yes	0	3
435	8x60	8x61	amine_on	0	0.462963	No	No	No	No	7	0
436	5x85	6x29	amine_on	0	0.462963	No	No	No	No	0	6
437	6x20	6x23	amine_on	0	0.555556	No	No	No	No	0	0
438	5x81	5x84	amine_on	0	0.462963	No	No	No	No	0	0
439	4x37	4x38	amine_on	0	0	No	No	No	Yes	0	8
440	4x36	4x37	amine_on	0	0	No	No	No	No	0	0
441	6x19	6x23	amine_on	0	0.555556	No	No	No	No	0	0
442	6x23	6x26	amine_on	0	0.347222	No	No	No	No	0	0
443	5x83	5x86	amine_on	0	0	No	No	No	No	0	0
444	1x27	1x31	amine_on	0	0	No	No	No	Yes	0	3
445	6x18	6x22	amine_on	0	0.138889	No	No	No	No	0	0
446	6x14	6x15	amine_on	0	0.138889	No	No	No	No	0	0
447	6x15	6x18	amine_on	0	0.138889	No	No	No	No	0	0
448	6x62	E3	amine_on	0	0	No	No	Yes	Yes	0	4
449	6x22	6x24	amine_on	0	0	No	No	No	No	0	0
450	5x80	5x83	amine_on	0	0	No	No	No	No	0	0
451	6x15	6x16	amine_on	0	0	No	No	No	No	0	0
452	6x16	6x17	amine_on	0	0	No	No	No	No	0	0
453	6x17	6x20	amine_on	0	0	No	No	No	No	0	0
454	6x21	6x24	amine_on	0	0	No	No	No	No	0	0

Orange: nodes, hubs and links specific of amine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of amine_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	amine_off Avg Int. Strength	amine_on Avg Int. Strength	amine_off Num Of Links	amine_on Num Of Links	ConSurf
1	1x35	amine_off	0	0	4	2	4
2	2x60	amine_off	22.6667	19.7917	4	3	6
3	3x50	amine_off	28	0	6	3	9
4	I2x56	amine_off	0	0	5	3	5
5	5x36	amine_off	0	0	4	3	5
6	6x31	amine_off	0	0	5	2	5
7	6x55	amine_off	6.66667	0	4	2	6
8	7x34	amine_off	20	2.77778	4	1	4
9	7x38	amine_off	21	19.7917	4	3	6
10	7x45	amine_off	37.6667	0	5	3	9
11	I3	amine_off	0	0	4	2	0
12	NT	amine_off	8.88889	0	6	1	0
13	1x60	Shared	0	4.54545	4	6	6
14	2x42	Shared	35.3333	8.33333	5	4	8
15	2x50	Shared	35.1111	71.6835	4	5	9
16	2x57	Shared	45.6667	17.4242	5	5	7
17	E1x50	Shared	82.5	75.6965	5	7	7
18	3x37	Shared	21.6667	9.375	4	4	6
19	3x49	Shared	25.119	10.4167	4	4	9
20	3x51	Shared	16	25.6944	4	4	8
21	I2x53	Shared	27.3333	23.0556	4	5	7
22	E2	Shared	100	95.5555	15	15	3
23	5x39	Shared	6.66667	12.037	4	4	7
24	5x58	Shared	0	63.5101	4	5	9
25	6x44	Shared	71.963	53.0324	4	5	9
26	6x48	Shared	94.2857	100	7	8	8
27	6x51	Shared	79.2857	75.5555	6	5	7
28	6x52	Shared	47.5265	62.0833	5	5	7
29	E3	Shared	52.5992	30.6503	6	7	4
30	7x39	Shared	55.3333	12.5	5	4	6
31	7x42	Shared	97.5	99.6528	7	7	7
32	7x49	Shared	0	31.3847	4	4	9
33	7x53	Shared	30	69.8737	4	5	9
34	8x50	Shared	47.7778	52.42	5	6	8
35	Lig	Shared	100	100	14	11	0
36	1x31	amine_on	0	0	2	5	3
37	1x50	amine_on	17.7778	4.54545	3	4	9
38	2x46	amine_on	0	19.9537	1	4	9
39	E1x52	amine_on	8.57143	0	2	4	5
40	3x46	amine_on	0	0	1	4	9
41	4x38	amine_on	0	0	3	4	8
42	5x47	amine_on	20	71.9381	3	6	7
43	5x62	amine_on	0	0	2	5	6
44	6x41	amine_on	0	0	3	4	8
45	6x49	amine_on	0	0	2	4	7
46	7x30	amine_on	0	0	2	4	5
47	8x54	amine_on	5	0	3	4	7

Orange: nodes, hubs and links specific of amine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of amine_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	amine_off Recurrence	amine_on Recurrence	amine_off Hub1?	amine_on Hub1?	amine_off Hub2?	amine_on Hub2?	ConSurf1	ConSurf2
1	2x56	7x42	amine_off	10.5387	0.957318	No	No	Yes	Yes	7	7
2	2x53	2x56	amine_off	13.5028	0	No	No	No	No	8	7
3	7x49	7x53	amine_off	45.3598	0	Yes	Yes	Yes	Yes	9	9
4	7x53	8x50	amine_off	38.4978	0	Yes	Yes	Yes	Yes	9	8
5	3x37	4x53	amine_off	100	1.27895	Yes	Yes	No	No	6	8
6	3x38	4x53	amine_off	99.2725	0	No	No	No	No	7	8
7	3x38	4x50	amine_off	98.5352	1.5249	No	No	No	No	7	9
8	2x45	4x50	amine_off	97.0311	4.55956	No	No	No	No	9	9
9	2x45	4x46	amine_off	93.9048	1.5249	No	No	No	No	9	7
10	2x42	4x46	amine_off	93.0987	0	Yes	Yes	No	No	8	7
11	3x49	I2x57	amine_off	11.163	5.5585	Yes	Yes	No	No	9	6
12	2x38	I2x57	amine_off	12.4853	4.5028	No	No	No	No	6	6
13	2x38	4x39	amine_off	11.3989	3.01574	No	No	No	No	6	3
14	3x49	3x50	amine_off	13.1488	0	Yes	Yes	Yes	No	9	9
15	3x37	3x41	amine_off	10.9172	5.08173	Yes	Yes	No	No	6	6
16	3x49	I2x53	amine_off	69.362	5.58499	Yes	Yes	Yes	Yes	9	7
17	3x52	I2x53	amine_off	70.0157	1.50976	No	No	Yes	Yes	5	7
18	3x48	3x52	amine_off	68.9589	0	No	No	No	No	6	5
19	3x48	5x57	amine_off	67.8578	2.19086	No	No	No	No	6	6
20	6x52	Lig	amine_off	11.7578	6.95853	Yes	Yes	Yes	Yes	7	0
21	5x47	6x52	amine_off	15.1888	9.19479	No	Yes	Yes	Yes	7	7
22	5x54	6x41	amine_off	27.964	0	No	No	No	Yes	8	8
23	5x58	6x41	amine_off	23.5745	7.9045	Yes	Yes	No	Yes	9	8
24	5x58	5x62	amine_off	16.2259	0	Yes	Yes	No	Yes	9	6
25	6x40	7x49	amine_off	10.7993	0	No	No	Yes	Yes	8	9
26	2x60	7x38	amine_off	16.8256	0	Yes	No	Yes	No	6	6
27	6x51	7x38	amine_off	10.6518	1.38489	Yes	Yes	Yes	No	7	6
28	6x51	Lig	amine_off	15.8818	6.81474	Yes	Yes	Yes	Yes	7	0
29	6x51	7x34	amine_off	29.2666	1.7822	Yes	Yes	Yes	No	7	4
30	6x54	7x34	amine_off	31.7784	0	No	No	Yes	No	4	4
31	6x54	7x37	amine_off	29.188	1.69517	No	No	No	No	4	5
32	6x50	7x37	amine_off	13.4143	3.38656	No	No	No	No	9	5
33	6x55	Lig	amine_off	17.6317	0	Yes	No	Yes	Yes	6	0
34	6x55	7x34	amine_off	15.7098	0	Yes	No	Yes	No	6	4
35	7x34	E3	amine_off	11.9986	0	Yes	No	Yes	Yes	4	4
36	7x33	7x37	amine_off	13.4733	0	No	No	No	No	4	5
37	1x60	8x56	amine_off	11.6349	6.67852	Yes	Yes	No	No	6	4
38	8x52	8x56	amine_off	10.5731	0	No	No	No	No	4	4
39	6x48	6x51	amine_off	10.4994	0	Yes	Yes	Yes	Yes	8	7
40	7x38	Lig	amine_off	11.0598	0.961102	Yes	No	Yes	Yes	6	0
41	1x39	7x39	Shared	25.0393	13.3873	No	No	Yes	Yes	6	6
42	7x39	7x42	Shared	27.3398	17.5004	Yes	Yes	Yes	Yes	6	7
43	1x50	2x50	Shared	21.0087	100	No	Yes	Yes	Yes	9	9
44	7x42	Lig	Shared	52.8461	48.5129	Yes	Yes	Yes	Yes	7	0
45	6x48	Lig	Shared	56.6457	82.5904	Yes	Yes	Yes	Yes	8	0
46	6x48	7x45	Shared	65.1593	61.5938	Yes	Yes	Yes	No	8	9
47	7x45	7x49	Shared	65.9605	61.2835	Yes	No	Yes	Yes	9	9
48	8x50	I1x50	Shared	19.8978	22.2605	Yes	Yes	No	No	8	8
49	1x60	I1x50	Shared	17.5285	20.9815	Yes	Yes	No	No	6	8
50	5x461	Lig	Shared	98.0781	11.9759	No	No	Yes	Yes	6	0
51	3x37	5x461	Shared	97.7586	10.9127	Yes	Yes	No	No	6	6
52	2x42	3x49	Shared	88.8616	14.0571	Yes	Yes	Yes	Yes	8	9
53	1x50	2x51	Shared	12.8687	18.4918	No	Yes	No	No	9	7
54	1x47	2x51	Shared	10.0767	13.9133	No	No	No	No	6	7
55	2x60	3x28	Shared	26.6123	18.6242	Yes	No	No	No	6	6
56	3x28	E1x50	Shared	19.0572	16.5733	No	No	Yes	Yes	6	7
57	E2x52	Lig	Shared	23.1518	33.7937	No	No	Yes	Yes	4	0
58	E2	E2x52	Shared	21.1119	32.3748	Yes	Yes	No	No	3	4
59	3x47	5x57	Shared	33.607	55.9369	No	No	No	No	8	6
60	3x47	5x54	Shared	32.211	52.0546	No	No	No	No	8	8
61	3x51	5x57	Shared	39.3285	51.9638	Yes	Yes	No	No	8	6
62	3x51	3x55	Shared	24.1742	29.2606	Yes	Yes	No	No	8	7
63	3x55	3x56	Shared	22.6996	27.1719	No	No	No	No	7	6
64	3x56	I2x52	Shared	18.2167	22.9718	No	No	No	No	6	5
65	5x62	5x66	Shared	14.7021	29.6012	No	Yes	No	No	6	5
66	1x35	1x39	Shared	20.7088	11.2911	Yes	No	No	No	4	6
67	1x35	2x65	Shared	10.8976	10.0537	Yes	No	No	No	4	5
68	3x51	5x61	Shared	10.7354	15.389	Yes	Yes	No	No	8	9
69	I2x52	I2x56	Shared	16.6781	18.7415	No	No	Yes	No	5	5
70	4x41	I2x56	Shared	10.991	14.4619	No	No	Yes	No	7	5
71	2x57	7x42	Shared	17.3909	13.2322	Yes	Yes	Yes	Yes	7	7
72	2x60	7x42	Shared	12.1608	21.5302	Yes	No	Yes	Yes	6	7
73	2x50	7x49	Shared	20.5712	73.9519	Yes	Yes	Yes	Yes	9	9
74	1x50	2x47	amine_on	0	73.8308	No	Yes	No	No	9	8
75	1x53	2x47	amine_on	4.68443	71.7648	No	No	No	No	9	8
76	1x53	7x54	amine_on	0	69.6912	No	No	No	No	9	6
77	7x54	8x50	amine_on	0	67.6101	No	No	Yes	Yes	6	8
78	8x50	8x54	amine_on	9.48683	15.2944	Yes	Yes	No	Yes	8	7
79	1x57	8x50	amine_on	0	11.5975	No	No	Yes	Yes	7	8
80	3x43	7x49	amine_on	0	54.8093	No	No	Yes	Yes	8	9
81	3x43	7x53	amine_on	0	95.8945	No	No	Yes	Yes	8	9
82	3x46	7x53	amine_on	0	20.0166	No	Yes	Yes	Yes	9	9
83	2x42	3x46	amine_on	1.22886	23.9784	Yes	Yes	No	Yes	8	9
84	2x46	3x42	amine_on	1.62702	10.5381	No	Yes	No	No	9	8
85	6x44	6x48	amine_on	4.68443	43.3593	Yes	Yes	Yes	Yes	9	8
86	5x54	6x44	amine_on	0	52.4898	No	No	Yes	Yes	8	9
87	3x47	5x58	amine_on	0	63.1262	No	No	Yes	Yes	8	9
88	3x50	5x58	amine_on	0	41.7663	Yes	No	Yes	Yes	9	9
89	3x54	5x61	amine_on	9.15749	13.2435	No	No	No	No	9	9
90	6x51	6x55	amine_on	0.860204	11.5408	Yes	Yes	Yes	No	7	6
91	5x40	6x59	amine_on	0	10.1786	No	No	No	No	6	5
92	5x47	6x48	amine_on	0	10.2354	No	Yes	Yes	Yes	7	8
93	5x47	6x49	amine_on	0	15.0144	No	Yes	No	Yes	7	7
94	5x58	6x37	amine_on	0	64.5225	Yes	Yes	No	No	9	8
95	5x58	6x40	amine_on	0	37.7895	Yes	Yes	No	No	9	8
96	6x40	7x53	amine_on	0	38.6106	No	No	Yes	Yes	8	9
97	5x62	6x37	amine_on	0	62.7592	No	Yes	No	No	6	8
98	5x62	6x34	amine_on	0	25.0908	No	Yes	No	No	6	7
99	E2	E3	amine_on	0	13.4819	Yes	Yes	Yes	Yes	3	4
100	7x52	7x53	amine_on	0	10.1597	No	No	Yes	Yes	8	9
101	8x47	8x50	amine_on	3.0525	13.9133	No	No	Yes	Yes	8	8
102	1x47	2x55	amine_on	8.66595	11.6127	No	No	No	No	6	5
103	4x38	4x41	amine_on	9.87023	12.797	No	Yes	No	No	8	7
104	3x54	5x64	amine_on	7.5698	11.0792	No	No	No	No	9	6
105	5x66	6x30	amine_on	0	23.2178	No	No	No	No	5	7
106	5x68	6x30	amine_on	0	20.1907	No	No	No	No	7	7
107	6x31	6x34	amine_on	0	23.2329	Yes	No	No	No	5	7
108	3x50	7x53	amine_on	0	35.1143	Yes	No	Yes	Yes	9	9
109	6x27	6x31	amine_on	0	21.2956	No	No	Yes	No	0	5
110	5x68	5x72	amine_on	0	18.2534	No	No	No	No	7	0
111	6x26	6x27	amine_on	0	18.2534	No	No	No	No	0	0
112	5x72	5x76	amine_on	0	16.7323	No	No	No	No	0	0
113	5x76	I3	amine_on	1.1453	15.2111	No	No	Yes	No	0	0
114	5x73	I3	amine_on	0	13.69	No	No	Yes	No	0	0
115	5x73	5x77	amine_on	0	12.1689	No	No	No	No	0	0
116	2x46	2x50	amine_on	0	37.6911	No	Yes	Yes	Yes	9	9
117	2x46	3x43	amine_on	0	41.5658	No	Yes	No	No	9	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	8.07573	8.69229	1	1	2	1
2x56	7x42	Shared	5.23372	4.32038	1	1	2	1
2x57	7x39	Shared	3.99013	3.52152	1	1	2	2
2x57	7x42	Shared	5.64776	6.51864	1	1	2	1
2x60	7x39	amine_off	5.36956	0	1	0	2	2
3x29	E2x52	Shared	3.62787	3.13953	0	0	2	1
3x32	7x42	Shared	8.28145	9.45327	1	1	1	1
3x32	Lig	Shared	13.8604	11.6074	1	1	1	0
3x33	4x57	Shared	7.16548	7.53515	1	0	1	2
3x33	Lig	Shared	12.6951	12.7564	1	0	1	0
3x36	6x48	Shared	5.34228	4.56337	1	1	1	1
3x36	Lig	Shared	7.13221	8.37714	1	1	1	0
3x37	4x57	amine_off	4.13315	0	0	0	2	2
3x37	5x461	Shared	5.96745	5.30277	0	0	2	1
3x40	6x44	Shared	6.22475	3.57695	0	1	2	2
E2	E2	Shared	43.3017	49.8682	1	1	2	2
E2	E2x52	Shared	8.0274	7.06691	1	1	2	1
5x39	E2	Shared	6.89383	5.94861	1	1	2	2
E2x52	Lig	Shared	4.71609	3.69391	1	1	1	0
5x39	5x43	Shared	4.91902	5.15793	1	1	2	1
5x43	Lig	Shared	4.80817	3.67921	1	0	1	0
5x461	Lig	Shared	4.36226	3.59416	1	0	1	0
5x47	6x52	Shared	26.8282	18.5285	0	1	2	1
6x44	6x48	Shared	10.6633	5.36538	1	1	2	1
6x44	7x45	amine_off	6.82115	0	1	1	2	2
6x48	6x51	amine_off	5.24073	0	1	1	1	1
6x48	6x52	Shared	3.92302	4.87257	1	1	1	1
6x48	7x41	Shared	11.6868	8.57316	1	1	1	2
6x48	7x45	Shared	4.02268	9.57397	1	1	1	2
6x48	Lig	Shared	8.96077	4.38222	1	1	1	0
6x51	6x52	Shared	6.08988	5.5682	1	1	1	1
6x51	6x55	Shared	7.52625	5.09193	1	1	1	1
6x51	7x34	Shared	5.07759	3.12175	1	1	1	2
6x51	7x38	Shared	6.51115	5.89887	1	1	1	1
6x51	Lig	Shared	12.3818	12.0728	1	1	1	0
6x52	Lig	Shared	10.8017	5.93835	1	1	1	0
6x55	7x34	amine_off	3.74148	0	1	0	1	2
6x55	Lig	amine_off	4.68965	0	1	0	1	0
7x38	7x42	Shared	6.63363	6.44466	1	1	1	1
7x38	Lig	Shared	9.05479	7.49216	1	1	1	0
7x39	7x42	Shared	6.52592	7.22168	1	1	2	1
7x42	Lig	Shared	4.60857	5.41341	1	1	1	0
5x40	6x55	Shared	4.71704	3.92894	0	1	2	1
2x60	7x42	Shared	4.60153	5.50112	1	0	2	1
2x60	7x38	amine_off	4.42023	0	1	0	2	1
5x44	6x52	Shared	2.96611	3.81853	0	0	2	1
3x33	4x61	amine_off	2.5438	0	1	0	1	2
3x40	6x48	amine_on	0	8.88888	0	1	2	1
5x40	E2	amine_on	0	3.41791	0	1	2	2
5x47	6x44	amine_on	0	4.42017	0	1	2	2
5x47	6x48	amine_on	0	3.51465	0	1	2	1
4x61	E2	amine_on	0	3.27631	0	1	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	amine_off	adrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
	amine_on	adrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on

Network Difference
Value	amine_off	amine_on
I_min	3.50375	3.40806
Number of Linked Nodes	292	314
Number of Specific Nodes	2 (0.68%)	24 (7.64%)
Number of Shared Nodes	290 (99.32%)	290 (92.36%)
Number of Links	317	338
Number of Specific Links	116 (36.59%)	137 (40.53%)
Number of Shared Links	201 (63.41%)	201 (59.47%)
Number of Hubs	35	35
Number of Specific Hubs	12 (34.29%)	12 (34.29%)
Number of Shared Hubs	23 (65.71%)	23 (65.71%)
Average % Shared Neighbours (Jaccard)	48.06
Average % Shared Neighbours (Otsuka)	55.56
Average % Shared Neighbours (Overlap Coefficient)	63.67
Average % Shared Cliques (k3-6)	60.58
Graphlets Similarity	0.602626

Paths Difference
Value	amine_off	amine_on
Number Of Nodes in MetaPath	70	77
Specific Nodes in MetaPath	24 (34.29%)	31 (40.26%)
Shared Nodes in MetaPath	290 (99.32%)	290 (99.32%)
Number Of Links MetaPath	73	77
Specific Links in MetaPath	40 (54.79%)	44 (57.14%)
Shared Links in MetaPath	201 (63.41%)	201 (63.41%)
Number of Shortest Paths	48071	67721
Length Of Smallest Path	3	3
Average Path Length	14.6277	13.6887
Length of Longest Path	39	31
Minimum Path Strength	0.395675	0.240517
Average Path Strength	5.0463	4.64367
Maximum Path Strength	18.815	12.4444
Minimum Path Correlation	0.702272	0.700123
Average Path Correlation	0.896728	0.895776
Maximum Path Correlation	0.985717	0.985999
Minimum % Of Corr. Nodes	2.85714	3.7037
Average % Of Corr. Nodes	37.3256	37.8313
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	41.5572	41.7714
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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