psnGPCR

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Orange: nodes, hubs and links specific of at1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of at1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	at1_off Int. Strength	at1_on Int. Strength	at1_off Hub1?	at1_on Hub1?	at1_off Hub2?	at1_on Hub2?	ConSurf1	ConSurf2
1	NT.I12	NT.N14	at1_off	3.54	0	No	No	No	No	4	3
2	E2.F170	NT.L13	at1_off	3.655	0	No	No	No	No	3	4
3	7x27	NT.C18	at1_off	3.61	0	No	No	No	No	3	8
4	NT.K20	NT.R23	at1_off	4.335	0	No	No	No	No	6	4
5	1x32	NT.R23	at1_off	5.34	0	No	No	No	No	4	4
6	1x30	7x32	at1_off	4.37	0	No	No	Yes	No	6	1
7	1x31	7x32	at1_off	3.8	0	Yes	No	Yes	No	3	1
8	1x34	7x36	at1_off	5.83	0	No	No	Yes	No	4	6
9	1x35	2x64	at1_off	8.36	0	Yes	Yes	No	No	6	5
10	1x39	Lig	at1_off	9.995	0	Yes	Yes	Yes	Yes	7	0
11	1x42	7x43	at1_off	8.165	0	No	No	No	No	7	5
12	1x42	7x47	at1_off	5.725	0	No	No	No	No	7	8
13	1x47	2x54	at1_off	4.28	0	Yes	No	No	No	6	6
14	1x50	2x51	at1_off	3.43	0	No	No	No	No	9	7
15	1x53	7x53	at1_off	11.985	0	No	Yes	No	Yes	9	9
16	1x54	2x44	at1_off	3.725	0	No	No	No	No	7	5
17	1x58	I1x50	at1_off	3.515	0	No	No	No	No	4	7
18	2x38	3x49	at1_off	8.03	0	No	No	No	No	7	8
19	2x42	4x46	at1_off	4.89	0	Yes	Yes	No	No	7	7
20	2x43	7x53	at1_off	7.62	0	No	No	No	Yes	8	9
21	2x52	4x50	at1_off	3.265	0	No	No	Yes	Yes	7	9
22	2x53	2x57	at1_off	6.7	0	Yes	No	Yes	Yes	6	8
23	2x53	3x32	at1_off	6.55	0	Yes	No	No	No	6	6
24	2x53	7x42	at1_off	14.44	0	Yes	No	Yes	No	6	7
25	2x53	7x46	at1_off	13.895	0	Yes	No	Yes	No	6	9
26	2x59	E1x50	at1_off	3.42	0	No	No	Yes	Yes	6	9
27	2x60	E1x50	at1_off	10.31	0	Yes	Yes	Yes	Yes	7	9
28	2x60	3x29	at1_off	4.94	0	Yes	Yes	No	No	7	5
29	2x60	E2x50	at1_off	3.265	0	Yes	Yes	No	No	7	9
30	2x63	E2.V179	at1_off	3.155	0	Yes	Yes	No	No	5	3
31	7x35	E1.Y92	at1_off	3.475	0	No	No	Yes	Yes	5	4
32	3x26	E2.N168	at1_off	6.295	0	No	No	No	No	6	3
33	3x29	Lig	at1_off	3.345	0	No	No	Yes	Yes	5	0
34	3x34	4x57	at1_off	3.3	0	Yes	Yes	No	No	5	7
35	3x35	7x42	at1_off	6.975	0	No	No	Yes	No	8	7
36	3x35	7x46	at1_off	12.26	0	No	No	Yes	No	8	9
37	3x39	6x44	at1_off	5.285	0	No	No	Yes	No	9	9
38	3x41	4x49	at1_off	5.65	0	No	No	No	No	5	7
39	3x43	6x41	at1_off	5.215	0	No	No	No	No	8	8
40	3x43	6x44	at1_off	6.7	0	No	No	Yes	No	8	9
41	3x44	5x54	at1_off	7.6	0	No	No	Yes	No	7	8
42	3x46	6x37	at1_off	9.99	0	No	No	Yes	No	9	7
43	3x49	3x50	at1_off	6.55	0	No	No	No	No	8	9
44	3x50	3x53	at1_off	4.15	0	No	No	No	No	9	8
45	3x50	6x37	at1_off	3.76	0	No	No	Yes	No	9	7
46	3x51	5x57	at1_off	4.455	0	Yes	Yes	No	No	8	7
47	4x38	I2x54	at1_off	3.235	0	Yes	No	No	No	7	4
48	4x51	4x55	at1_off	4.15	0	No	No	No	No	4	4
49	4x63	4x64	at1_off	9.28	0	No	No	No	No	4	4
50	4x64	E2x52	at1_off	14.71	0	No	No	Yes	Yes	4	4
51	4x65	Lig	at1_off	24.47	0	No	No	Yes	Yes	5	0
52	E2.F170	E2.N168	at1_off	7.855	0	No	No	No	No	3	3
53	E2.T178	E2.V169	at1_off	4.76	0	No	No	No	No	4	5
54	E2.I172	E2.I177	at1_off	6.625	0	No	No	No	No	5	1
55	5x39	5x42	at1_off	3.685	0	No	No	No	No	5	3
56	5x44	5x47	at1_off	6.645	0	Yes	No	Yes	Yes	4	8
57	5x44	5x48	at1_off	5.49	0	Yes	No	No	No	4	4
58	5x49	5x53	at1_off	4.395	0	No	No	No	No	6	7
59	5x54	5x58	at1_off	3.63	0	Yes	No	Yes	Yes	8	9
60	5x54	6x45	at1_off	4.395	0	Yes	No	Yes	Yes	8	5
61	5x61	6x34	at1_off	8.795	0	No	No	No	Yes	8	6
62	5x65	6x31	at1_off	6.105	0	No	No	No	No	8	4
63	5x66	5x67	at1_off	3.59	0	No	No	No	No	5	4
64	6x30	6x31	at1_off	4.71	0	No	No	No	No	6	4
65	6x32	6x35	at1_off	3.455	0	No	No	No	No	7	5
66	6x32	8x49	at1_off	5.53	0	No	No	No	No	7	6
67	6x35	7x55	at1_off	10.545	0	No	No	No	No	5	6
68	6x36	7x53	at1_off	4.23	0	No	No	No	Yes	8	9
69	6x36	7x55	at1_off	3.77	0	No	No	No	No	8	6
70	6x40	7x49	at1_off	8.5	0	No	No	No	No	8	9
71	6x40	7x52	at1_off	3.77	0	No	No	Yes	No	8	8
72	6x41	6x45	at1_off	3.275	0	No	No	Yes	Yes	8	5
73	6x44	6x45	at1_off	5.895	0	Yes	No	Yes	Yes	9	5
74	6x44	7x45	at1_off	7.855	0	Yes	No	No	No	9	9
75	6x48	6x51	at1_off	3.175	0	Yes	Yes	Yes	Yes	8	6
76	6x48	7x41	at1_off	9.725	0	Yes	Yes	No	No	8	8
77	6x48	7x42	at1_off	7.235	0	Yes	Yes	Yes	No	8	7
78	6x58	6x62	at1_off	9.14	0	No	No	No	No	4	3
79	6x58	7x34	at1_off	5.545	0	No	No	No	No	4	4
80	6x61	7x27	at1_off	3.25	0	No	No	No	No	2	3
81	6x63	E3.I270	at1_off	4.995	0	Yes	No	No	No	1	2
82	7x23	7x26	at1_off	11.895	0	No	No	No	No	4	1
83	7x25	7x29	at1_off	4.385	0	No	No	No	No	2	1
84	7x42	Lig	at1_off	3.76	0	Yes	No	Yes	Yes	7	0
85	7x43	7x47	at1_off	3.49	0	No	No	No	No	5	8
86	7x45	7x46	at1_off	8.175	0	No	No	Yes	No	9	9
87	7x45	7x49	at1_off	11.58	0	No	No	No	No	9	9
88	7x48	7x52	at1_off	4.26	0	No	No	Yes	No	6	8
89	3x54	6x30	at1_off	4.25	0	No	No	No	No	8	6
90	5x47	5x51	at1_off	6.965	0	Yes	Yes	No	No	8	6
91	6x34	6x38	at1_off	3.11	0	No	Yes	No	No	6	4
92	E3.R272	NT.D17	at1_off	2.98	0	No	No	No	No	1	6
93	6x33	6x37	at1_off	2.94	0	No	No	Yes	No	7	7
94	6x58	7x30	at1_off	2.92	0	No	No	Yes	No	4	4
95	7x30	7x31	at1_off	2.92	0	Yes	No	No	No	4	4
96	4x59	4x63	at1_off	2.855	0	No	No	No	No	4	4
97	5x37	6x63	at1_off	2.855	0	No	No	Yes	No	2	1
98	2x42	4x42	at1_off	2.77	0	Yes	Yes	No	No	7	7
99	2x46	3x42	at1_off	2.77	0	No	Yes	No	No	9	7
100	3x34	3x38	at1_off	2.77	0	Yes	Yes	No	No	5	7
101	6x54	7x30	at1_off	2.62	0	No	No	Yes	No	5	4
102	5x40	5x43	at1_off	2.615	0	No	No	No	Yes	5	5
103	E1x49	E2.T178	at1_off	2.585	0	No	No	No	No	5	4
104	1x31	7x35	at1_off	2.54	0	Yes	No	No	No	3	5
105	6x46	6x49	at1_off	2.51	0	No	No	No	Yes	6	5
106	4x64	E2.E185	at1_off	2.46	0	No	No	No	No	4	5
107	1x60	I1x48	at1_off	2.395	0	Yes	Yes	No	No	4	5
108	2x38	4x38	at1_off	2.38	0	No	No	Yes	No	7	7
109	7x25	7x28	at1_off	2.38	0	No	No	No	No	2	4
110	E2.E173	NT.P19	at1_off	2.36	0	No	No	No	Yes	0	4
111	8x53	8x57	at1_off	2.345	0	No	Yes	No	No	5	4
112	6x47	7x40	at1_off	2.325	0	No	No	No	No	8	8
113	2x39	3x49	at1_off	2.315	0	No	No	No	No	7	8
114	4x38	I2x55	at1_off	2.21	0	Yes	No	No	No	7	4
115	E2.E173	NT.S15	at1_off	2.155	0	No	No	No	No	0	4
116	4x48	4x52	at1_off	2.14	0	No	No	No	No	3	4
117	I1x51	I2x55	at1_off	2.115	0	No	No	No	No	7	4
118	8x57	8x58	at1_off	2.075	0	No	No	No	No	4	6
119	1x60	8x50	at1_off	2.065	0	Yes	Yes	No	Yes	4	8
120	5x41	5x44	at1_off	2.06	0	No	No	Yes	No	4	4
121	4x61	Lig	at1_off	2.02	0	No	No	Yes	Yes	4	0
122	1x43	1x44	at1_off	1.965	0	Yes	No	No	No	6	5
123	E1x49	E2.N176	at1_off	1.81	0	No	No	No	No	5	0
124	2x49	3x38	at1_off	1.79	0	No	No	No	No	8	7
125	3x30	4x61	at1_off	1.79	0	No	No	No	No	5	4
126	5x37	5x38	at1_off	1.765	0	No	No	No	No	2	4
127	1x45	7x47	at1_off	1.71	0	No	No	No	No	5	8
128	2x48	4x50	at1_off	1.71	0	No	No	Yes	Yes	5	9
129	5x46	5x461	at1_off	1.71	0	No	No	No	No	4	5
130	2x56	3x28	at1_off	1.68	0	No	No	No	No	7	6
131	5x35	5x36	at1_off	1.64	0	No	No	No	No	1	3
132	I2x54	I2x57	at1_off	1.6	0	No	No	No	Yes	4	6
133	5x42	5x45	at1_off	1.52	0	No	No	No	No	3	5
134	5x59	5x63	at1_off	1.5	0	No	No	No	No	3	3
135	5x35	E2.S189	at1_off	1.5	0	No	No	No	No	1	0
136	NT.D17	NT.S16	at1_off	1.47	0	No	No	No	No	6	4
137	1x37	1x38	at1_off	1.47	0	No	No	No	No	6	5
138	7x36	7x40	at1_off	1.47	0	Yes	No	No	No	6	8
139	1x31	7x36	at1_off	1.47	0	Yes	No	Yes	No	3	6
140	8x48	8x49	at1_off	1.435	0	No	No	No	No	5	6
141	8x48	8x51	at1_off	1.435	0	No	No	No	No	5	8
142	3x24	3x27	at1_off	1.425	0	No	No	No	No	5	6
143	7x48	7x51	at1_off	1.385	0	No	No	No	No	6	6
144	1x44	1x48	at1_off	1.31	0	No	No	No	No	5	4
145	1x56	1x60	at1_off	1.26	0	No	No	Yes	Yes	7	4
146	NT.P19	NT.S16	at1_off	0.89	0	No	Yes	No	No	4	4
147	6x63	6x64	at1_off	0.855	0	Yes	No	No	No	1	2
148	E2.V179	E2x51	at1_off	0.85	0	No	No	No	No	3	5
149	3x54	5x64	at1_off	0.81	0	No	No	No	No	8	5
150	5x61	5x64	at1_off	0.81	0	No	No	No	No	8	5
151	8x47	8x50	at1_off	0.755	0	No	No	No	Yes	8	8
152	7x54	7x55	at1_off	0.755	0	No	No	No	No	7	6
153	5x59	5x60	at1_off	0.735	0	No	No	No	No	3	3
154	1x47	2x55	at1_off	0.715	0	Yes	No	No	No	6	4
155	4x48	4x51	at1_off	0.715	0	No	No	No	No	3	4
156	1x52	1x55	at1_off	0.715	0	No	No	No	No	6	3
157	E2.I172	NT.N14	at1_off	0.71	0	No	No	No	No	5	3
158	E2.N174	NT.I12	at1_off	0.71	0	No	No	No	No	0	4
159	5x48	5x52	at1_off	0.69	0	No	No	No	No	4	3
160	7x24	NT.C18	Shared	7.28	7.28	No	No	No	No	7	8
161	7x31	NT.A21	Shared	4.63	4.63	No	No	No	No	4	4
162	E1.Y92	NT.R23	Shared	6.175	7.2	Yes	Yes	No	No	4	4
163	1x28	1x30	Shared	9.255	10.89	No	Yes	No	No	4	6
164	1x28	7x28	Shared	10.715	7.56	No	Yes	No	No	4	4
165	1x28	7x32	Shared	7.53	5.48	No	Yes	Yes	No	4	1
166	1x30	1x31	Shared	5.44	7.25	No	No	Yes	No	6	3
167	1x32	2x67	Shared	15.74	16.32	No	No	No	No	4	3
168	1x32	E1.Y92	Shared	6.705	4.13	No	No	Yes	Yes	4	4
169	1x35	1x36	Shared	3.39	3.39	Yes	Yes	No	No	6	5
170	1x35	1x39	Shared	7.25	6.04	Yes	Yes	Yes	Yes	6	7
171	1x35	7x35	Shared	3.39	5.08	Yes	Yes	No	No	6	5
172	1x36	2x65	Shared	3.74	3.74	No	No	No	No	5	3
173	1x39	2x57	Shared	7.615	8.21	Yes	Yes	Yes	Yes	7	8
174	1x39	2x61	Shared	3.335	2.67	Yes	Yes	No	No	7	7
175	1x39	7x39	Shared	5.375	4.03	Yes	Yes	No	No	7	5
176	1x43	1x47	Shared	8.79	5.02	Yes	No	Yes	No	6	6
177	1x43	2x58	Shared	11.555	14.45	Yes	No	No	No	6	9
178	1x46	2x54	Shared	3.42	1.71	No	Yes	No	No	8	6
179	1x49	7x50	Shared	4.06	2.03	No	No	No	No	7	9
180	1x50	2x50	Shared	9.425	6.73	No	No	Yes	Yes	9	9
181	1x50	7x50	Shared	11.4	11.4	No	No	No	No	9	9
182	1x57	2x44	Shared	9.995	4.28	No	No	No	No	7	5
183	2x40	I1x48	Shared	5.365	7.67	No	No	No	No	8	5
184	2x40	I1x50	Shared	3.755	3	No	No	No	No	8	7
185	2x44	I1x50	Shared	4.845	5.54	No	No	No	No	5	7
186	2x42	3x45	Shared	12.57	4.19	Yes	Yes	No	No	7	7
187	2x42	3x46	Shared	4.875	3.65	Yes	Yes	No	No	7	9
188	2x42	4x45	Shared	4.54	5.19	Yes	Yes	No	No	7	5
189	2x43	3x46	Shared	4.845	2.77	No	No	No	No	8	9
190	2x45	4x46	Shared	11.02	7.87	No	No	No	No	9	7
191	2x45	4x50	Shared	4.52	6.78	No	No	Yes	Yes	9	9
192	2x46	2x50	Shared	4.75	4.07	No	Yes	Yes	Yes	9	9
193	2x50	7x46	Shared	12.115	4.63	Yes	Yes	Yes	No	9	9
194	2x50	7x49	Shared	6.06	6.73	Yes	Yes	No	No	9	9
195	2x53	3x35	Shared	13.29	1.56	Yes	No	No	No	6	8
196	2x56	3x31	Shared	7.995	6.4	No	No	No	No	7	5
197	2x59	E1x52	Shared	11.57	4.87	No	No	Yes	Yes	6	6
198	2x60	2x63	Shared	4.82	3.86	Yes	Yes	Yes	Yes	7	5
199	2x60	3x28	Shared	3.89	3.89	Yes	Yes	No	No	7	6
200	2x60	Lig	Shared	27.54	16.21	Yes	Yes	Yes	Yes	7	0
201	2x62	E1x52	Shared	3.275	2.62	No	No	Yes	Yes	4	6
202	2x63	E1.Y92	Shared	6.45	10.92	Yes	Yes	Yes	Yes	5	4
203	2x63	E1x50	Shared	8.2	10.61	Yes	Yes	Yes	Yes	5	9
204	2x64	E1.Y92	Shared	5.62	7.49	No	No	Yes	Yes	5	4
205	2x66	E1x51	Shared	4.19	3.35	No	No	No	No	5	3
206	E1x49	E2.I177	Shared	10.02	5.01	No	No	No	No	5	1
207	E1x50	E1x52	Shared	12.025	17.04	Yes	Yes	Yes	Yes	9	6
208	3x25	E1x50	Shared	4.57	9.14	No	No	Yes	Yes	9	9
209	E1x50	E2x50	Shared	11.1	15.67	Yes	Yes	No	No	9	9
210	E1x51	E1x52	Shared	13	7.22	No	No	Yes	Yes	3	6
211	3x24	E1x52	Shared	4.26	6.09	No	No	Yes	Yes	5	6
212	3x22	3x26	Shared	4.2	8.39	No	No	No	No	3	6
213	3x22	E2.N168	Shared	9.54	6.81	No	No	No	No	3	3
214	3x22	E2.V169	Shared	5.17	5.91	No	No	No	No	3	5
215	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
216	3x29	4x65	Shared	13.835	15.81	No	No	No	No	5	5
217	3x30	4x62	Shared	3.25	4.87	No	No	No	No	5	5
218	3x32	7x42	Shared	5.05	3.79	No	No	Yes	No	6	7
219	3x32	Lig	Shared	15.23	3.93	No	No	Yes	Yes	6	0
220	3x33	4x57	Shared	3.26	6.52	No	No	No	No	4	7
221	3x33	Lig	Shared	13.42	5.28	No	No	Yes	Yes	4	0
222	3x34	4x50	Shared	10.02	7.02	Yes	Yes	Yes	Yes	5	9
223	3x34	4x53	Shared	6.24	2.77	Yes	Yes	No	No	5	8
224	3x36	6x48	Shared	13.67	3.42	No	No	Yes	Yes	7	8
225	3x37	3x41	Shared	3.61	6.19	No	Yes	No	No	7	5
226	3x37	4x56	Shared	9.34	8.01	No	Yes	No	No	7	5
227	3x37	5x43	Shared	5.975	4.78	No	Yes	No	Yes	7	5
228	3x40	5x50	Shared	3.53	3.53	No	No	Yes	Yes	8	8
229	3x42	4x49	Shared	4.28	2.85	No	No	No	No	7	7
230	3x47	5x54	Shared	10.065	4.64	No	No	Yes	No	9	8
231	3x47	5x57	Shared	3.26	4.89	No	No	No	No	9	7
232	3x47	5x58	Shared	11.45	5.09	No	No	Yes	Yes	9	9
233	3x51	3x52	Shared	3.52	3.52	Yes	Yes	No	No	8	5
234	3x51	3x55	Shared	11.36	11.36	Yes	Yes	No	No	8	7
235	3x51	3x56	Shared	7.08	8.71	Yes	Yes	No	No	8	6
236	3x51	5x60	Shared	5.275	8.21	Yes	Yes	No	No	8	3
237	3x54	5x61	Shared	11.775	4.42	No	No	No	No	8	8
238	3x55	3x56	Shared	7.61	11.07	No	No	No	No	7	6
239	4x65	E2x52	Shared	3.21	17.1	No	No	Yes	Yes	5	4
240	E2.F171	E2.T178	Shared	4.54	2.59	No	No	No	No	6	4
241	E2.I172	E2.V179	Shared	5.375	3.07	No	No	No	No	5	3
242	E2.Y184	E2x52	Shared	12.895	4.13	No	Yes	Yes	Yes	4	4
243	E2x52	Lig	Shared	5.88	6.19	Yes	Yes	Yes	Yes	4	0
244	6x62	E2.Y184	Shared	9.585	12.4	No	No	No	Yes	3	4
245	5x47	6x45	Shared	4.285	6.43	Yes	Yes	Yes	Yes	8	5
246	5x47	6x52	Shared	13.47	10.54	Yes	Yes	No	No	8	8
247	5x49	5x50	Shared	4.33	1.44	No	No	Yes	Yes	6	8
248	5x51	6x45	Shared	23.58	9.65	No	No	Yes	Yes	6	5
249	5x58	6x37	Shared	4.235	3.63	Yes	Yes	Yes	No	9	7
250	5x58	6x41	Shared	10.095	5.05	Yes	Yes	No	No	9	8
251	5x62	5x66	Shared	6.38	3.48	No	Yes	No	No	5	5
252	5x62	6x34	Shared	3.51	10.02	No	Yes	No	Yes	5	6
253	6x31	6x32	Shared	3.325	10.65	No	No	No	No	4	7
254	6x36	7x56	Shared	3.57	4.28	No	No	No	No	8	7
255	6x39	7x52	Shared	8.32	2.77	No	No	Yes	No	5	8
256	6x43	6x47	Shared	7.265	3.96	No	Yes	No	No	6	8
257	6x43	7x48	Shared	9.135	7.31	No	Yes	No	No	6	6
258	6x43	7x52	Shared	4.29	11.79	No	Yes	Yes	No	6	8
259	6x44	6x48	Shared	8.015	5.01	Yes	No	Yes	Yes	9	8
260	6x49	6x50	Shared	3.39	5.08	No	Yes	No	No	5	9
261	6x51	6x55	Shared	5.475	6.85	Yes	Yes	No	No	6	6
262	6x51	7x37	Shared	8.895	8.21	Yes	Yes	No	No	6	7
263	6x51	7x38	Shared	9.28	3.98	Yes	Yes	No	No	6	6
264	6x54	7x33	Shared	7.625	8.32	No	No	No	No	5	5
265	6x56	6x60	Shared	6.09	6.09	No	No	No	No	5	3
266	6x57	7x30	Shared	5.215	2.98	No	No	Yes	No	5	4
267	6x60	E3.I270	Shared	4.28	5.71	No	No	No	No	3	2
268	6x60	E3.I271	Shared	3.57	4.28	No	No	No	No	3	1
269	6x61	7x30	Shared	4.61	4.61	No	No	Yes	No	2	4
270	7x26	E3.I271	Shared	5.89	4.42	No	No	No	No	1	1
271	7x23	7x25	Shared	4.165	4.76	No	No	No	No	4	2
272	7x38	Lig	Shared	9.15	6.41	No	No	Yes	Yes	6	0
273	5x44	6x52	Shared	5.94	3.96	Yes	No	No	No	4	8
274	E2.E185	E2.H183	Shared	3.075	4.92	No	No	No	Yes	5	3
275	1x53	1x57	Shared	3.07	3.07	No	Yes	No	No	9	7
276	E2.I177	E2.T175	Shared	3.04	9.12	No	No	No	No	1	0
277	6x59	6x63	Shared	2.98	1.49	No	No	Yes	No	4	1
278	3x48	5x53	Shared	2.94	2.94	No	No	No	No	6	7
279	6x49	6x53	Shared	2.94	4.42	No	Yes	No	No	5	6
280	1x42	2x57	Shared	2.85	2.85	No	No	Yes	Yes	7	8
281	6x38	6x42	Shared	2.825	2.83	No	No	No	No	4	5
282	3x21	E1x50	Shared	2.81	2.81	No	No	Yes	Yes	8	9
283	3x44	5x50	Shared	2.625	3.5	No	No	Yes	Yes	7	8
284	6x50	7x37	Shared	2.625	3.5	No	No	No	No	9	7
285	1x53	2x47	Shared	2.545	1.7	No	Yes	No	No	9	8
286	2x41	4x42	Shared	2.545	5.09	No	Yes	No	No	6	7
287	1x60	8x53	Shared	2.48	10.92	Yes	Yes	No	Yes	4	5
288	1x43	2x57	Shared	2.435	3.65	Yes	No	Yes	Yes	6	8
289	3x41	4x52	Shared	2.435	3.65	No	No	No	No	5	4
290	2x37	2x40	Shared	2.4	4.8	No	No	No	No	8	8
291	1x38	7x39	Shared	2.38	6.35	No	No	No	No	5	5
292	3x34	4x54	Shared	2.26	3.01	Yes	Yes	No	No	5	3
293	5x36	E2.Y184	Shared	2.085	4.17	No	No	No	Yes	3	4
294	1x58	1x59	Shared	2.06	7.22	No	No	No	No	4	4
295	5x461	5x50	Shared	2.03	4.06	No	No	Yes	Yes	5	8
296	I2x51	I2x54	Shared	1.86	1.24	No	No	No	No	6	4
297	7x32	NT.G22	Shared	1.82	1.82	Yes	No	No	No	1	2
298	4x59	4x60	Shared	1.64	3.28	No	No	No	No	4	6
299	4x38	4x41	Shared	1.585	3.17	Yes	No	No	No	7	4
300	1x41	1x45	Shared	1.54	1.54	No	No	No	No	5	5
301	4x44	4x48	Shared	1.54	3.07	No	No	No	No	3	3
302	2x41	4x39	Shared	1.52	1.52	No	Yes	No	No	6	1
303	2x41	4x43	Shared	1.52	4.55	No	Yes	No	No	6	3
304	5x42	5x46	Shared	1.475	2.95	No	No	No	No	3	4
305	5x55	5x59	Shared	1.475	2.95	No	No	No	No	5	3
306	1x35	7x36	Shared	1.47	2.94	Yes	Yes	Yes	No	6	6
307	1x55	1x59	Shared	1.255	3.77	No	No	No	No	3	4
308	8x52	8x56	Shared	1.17	8.18	No	No	No	No	5	3
309	NT.C18	NT.P19	Shared	0.94	1.88	No	No	No	Yes	8	4
310	1x47	1x51	Shared	0.775	1.55	Yes	No	No	No	6	3
311	3x56	I2x50	Shared	0.765	1.53	No	No	No	No	6	8
312	4x40	4x44	Shared	0.745	1.49	No	No	No	No	4	3
313	E2.V169	NT.I11	at1_on	0	4.61	No	No	No	No	5	0
314	NT.I14	NT.K12	at1_on	0	5.82	No	No	No	No	0	0
315	E2.F170	NT.K12	at1_on	0	6.2	No	No	No	No	3	0
316	E2.F171	NT.R13	at1_on	0	8.55	No	No	No	No	6	0
317	E2.E173	NT.R13	at1_on	0	4.65	No	No	No	No	0	0
318	E2.F170	NT.I14	at1_on	0	10.05	No	No	No	No	3	0
319	E2.H183	NT.I14	at1_on	0	13.26	No	Yes	No	No	3	0
320	E2.E173	NT.Q15	at1_on	0	7.65	No	No	No	No	0	0
321	E2.N174	NT.Q15	at1_on	0	3.96	No	No	No	No	0	0
322	NT.D16	NT.P19	at1_on	0	6.44	No	No	No	Yes	0	4
323	Lig	NT.D16	at1_on	0	7.25	Yes	Yes	No	No	0	0
324	Lig	NT.D17	at1_on	0	4.22	Yes	Yes	No	No	0	6
325	E2.N174	NT.P19	at1_on	0	3.26	No	No	No	Yes	0	4
326	Lig	NT.R23	at1_on	0	3.76	Yes	Yes	No	No	0	4
327	1x28	1x31	at1_on	0	5.3	No	Yes	Yes	No	4	3
328	1x39	7x38	at1_on	0	6.04	Yes	Yes	No	No	7	6
329	1x52	7x55	at1_on	0	3.65	No	No	No	No	6	6
330	1x52	8x54	at1_on	0	6.09	No	No	No	No	6	7
331	1x53	7x50	at1_on	0	3.53	No	Yes	No	No	9	9
332	1x56	8x50	at1_on	0	3.93	No	No	No	Yes	7	8
333	1x56	8x53	at1_on	0	3.79	No	No	No	Yes	7	5
334	1x60	8x56	at1_on	0	7.89	Yes	Yes	No	No	4	3
335	1x60	8x57	at1_on	0	8.21	Yes	Yes	No	No	4	4
336	1x60	8x60	at1_on	0	3.97	Yes	Yes	No	No	4	0
337	I1x49	I1x51	at1_on	0	5.75	No	No	No	No	5	7
338	2x42	3x49	at1_on	0	9.55	Yes	Yes	No	No	7	8
339	2x45	3x42	at1_on	0	4.12	No	No	No	No	9	7
340	2x46	3x43	at1_on	0	5.54	No	Yes	No	No	9	8
341	2x46	7x49	at1_on	0	4.12	No	Yes	No	No	9	9
342	2x46	7x53	at1_on	0	3.52	No	Yes	No	Yes	9	9
343	2x50	3x39	at1_on	0	5.89	Yes	Yes	No	No	9	9
344	2x52	3x35	at1_on	0	6.3	No	No	No	No	7	8
345	2x56	2x59	at1_on	0	4.42	No	No	No	No	7	6
346	2x56	2x60	at1_on	0	4.85	No	No	Yes	Yes	7	7
347	2x57	7x42	at1_on	0	8.21	Yes	Yes	Yes	No	8	7
348	2x63	Lig	at1_on	0	4.84	Yes	Yes	Yes	Yes	5	0
349	2x67	E1x49	at1_on	0	10.47	No	No	No	No	3	5
350	E1.Y92	Lig	at1_on	0	10.64	Yes	Yes	Yes	Yes	4	0
351	3x33	4x61	at1_on	0	3.42	No	No	No	No	4	4
352	3x34	3x35	at1_on	0	4.83	Yes	Yes	No	No	5	8
353	3x36	7x42	at1_on	0	7.03	No	No	Yes	No	7	7
354	3x36	Lig	at1_on	0	4.87	No	No	Yes	Yes	7	0
355	3x37	5x42	at1_on	0	4.99	No	Yes	No	No	7	3
356	3x37	Lig	at1_on	0	4.13	No	Yes	Yes	Yes	7	0
357	3x38	4x50	at1_on	0	6.48	No	No	Yes	Yes	7	9
358	3x40	6x48	at1_on	0	4.9	No	No	Yes	Yes	8	8
359	3x43	7x53	at1_on	0	5.86	No	No	No	Yes	8	9
360	3x44	5x53	at1_on	0	6.08	No	No	No	No	7	7
361	3x45	4x49	at1_on	0	3.27	No	No	No	No	7	7
362	3x49	I2x57	at1_on	0	10.72	No	No	No	Yes	8	6
363	3x50	5x58	at1_on	0	8.23	No	No	Yes	Yes	9	9
364	3x50	7x53	at1_on	0	7.2	No	No	No	Yes	9	9
365	3x51	5x61	at1_on	0	3.63	Yes	Yes	No	No	8	8
366	3x52	I2x57	at1_on	0	3.64	No	No	No	Yes	5	6
367	3x53	I2x57	at1_on	0	5.53	No	No	No	Yes	8	6
368	3x55	5x64	at1_on	0	5.09	No	No	No	No	7	5
369	I2x53	I2x57	at1_on	0	6.59	No	No	No	Yes	6	6
370	4x64	5x36	at1_on	0	4.58	No	No	No	No	4	3
371	E2.V169	E2x50	at1_on	0	5.12	No	No	No	No	5	9
372	E2.F170	E2.H183	at1_on	0	3.39	No	No	No	Yes	3	3
373	E2.F171	E2.N176	at1_on	0	3.62	No	No	No	No	6	0
374	E2.E173	E2.N174	at1_on	0	3.94	No	No	No	No	0	0
375	E2.V179	Lig	at1_on	0	4.67	No	No	Yes	Yes	3	0
376	E2x51	Lig	at1_on	0	4.95	No	No	Yes	Yes	5	0
377	5x39	E2x52	at1_on	0	4.87	No	No	Yes	Yes	5	4
378	E2.H183	Lig	at1_on	0	16.04	No	Yes	Yes	Yes	3	0
379	E2.Y184	Lig	at1_on	0	12.09	No	Yes	Yes	Yes	4	0
380	E2.E185	E2.S189	at1_on	0	4.31	No	No	No	No	5	0
381	E2.N188	E2.Q187	at1_on	0	13.2	No	No	No	No	0	0
382	5x36	E2.S189	at1_on	0	8.91	No	No	No	No	3	0
383	6x62	E2.S189	at1_on	0	5.78	No	No	No	No	3	0
384	5x37	6x62	at1_on	0	6.86	No	No	No	No	2	3
385	5x43	6x51	at1_on	0	7.86	No	Yes	Yes	Yes	5	6
386	5x43	6x55	at1_on	0	10.51	No	Yes	No	No	5	6
387	5x43	Lig	at1_on	0	24.77	No	Yes	Yes	Yes	5	0
388	5x44	6x56	at1_on	0	3.62	Yes	No	No	No	4	5
389	5x47	6x49	at1_on	0	3.77	Yes	Yes	No	Yes	8	5
390	5x51	5x55	at1_on	0	6.09	No	No	No	No	6	5
391	5x54	6x44	at1_on	0	5.02	Yes	No	Yes	No	8	9
392	5x58	6x40	at1_on	0	4.84	Yes	Yes	No	No	9	8
393	5x62	6x37	at1_on	0	5.87	No	Yes	Yes	No	5	7
394	5x62	6x38	at1_on	0	4.65	No	Yes	No	No	5	4
395	5x65	6x34	at1_on	0	4.87	No	No	No	Yes	8	6
396	5x66	6x34	at1_on	0	8.69	No	No	No	Yes	5	6
397	6x28	I3.Y226	at1_on	0	5.56	No	No	No	Yes	0	0
398	6x30	I3.Y226	at1_on	0	6.98	No	No	No	Yes	6	0
399	6x33	I3.Y226	at1_on	0	4.84	No	No	No	Yes	7	0
400	6x29	I3.K232	at1_on	0	3.71	No	No	No	No	0	0
401	6x28	6x30	at1_on	0	6.52	No	No	No	No	0	6
402	6x30	6x34	at1_on	0	6.04	No	No	No	Yes	6	6
403	6x33	6x34	at1_on	0	3.77	No	No	No	Yes	7	6
404	6x40	7x53	at1_on	0	8.46	No	No	No	Yes	8	9
405	6x43	7x45	at1_on	0	6.04	No	Yes	No	No	6	9
406	6x45	6x46	at1_on	0	10.72	Yes	Yes	No	No	5	6
407	6x45	6x49	at1_on	0	7.54	Yes	Yes	No	Yes	5	5
408	6x47	7x45	at1_on	0	8.94	No	No	No	No	8	9
409	6x48	6x52	at1_on	0	3.29	Yes	Yes	No	No	8	8
410	6x48	7x45	at1_on	0	7.91	Yes	Yes	No	No	8	9
411	6x50	7x40	at1_on	0	5.08	No	No	No	No	9	8
412	6x51	7x34	at1_on	0	3.94	Yes	Yes	No	No	6	4
413	6x51	Lig	at1_on	0	7.92	Yes	Yes	Yes	Yes	6	0
414	6x58	Lig	at1_on	0	14.05	No	No	Yes	Yes	4	0
415	6x61	E3.I271	at1_on	0	5.89	No	No	No	No	2	1
416	6x61	Lig	at1_on	0	5.01	No	No	Yes	Yes	2	0
417	7x24	7x27	at1_on	0	3.61	No	No	No	No	7	3
418	7x26	7x29	at1_on	0	4.42	No	No	No	No	1	1
419	7x28	7x32	at1_on	0	4.34	No	No	Yes	No	4	1
420	7x31	Lig	at1_on	0	22.07	No	No	Yes	Yes	4	0
421	7x34	Lig	at1_on	0	13.98	No	No	Yes	Yes	4	0
422	7x35	Lig	at1_on	0	7.63	No	No	Yes	Yes	5	0
423	7x40	7x43	at1_on	0	5.02	No	No	No	No	8	5
424	7x49	7x53	at1_on	0	3.49	No	No	No	Yes	9	9
425	7x55	8x50	at1_on	0	5.36	No	No	No	Yes	6	8
426	8x49	8x53	at1_on	0	9.55	No	No	No	Yes	6	5
427	8x50	8x53	at1_on	0	4.13	No	Yes	No	Yes	8	5
428	8x52	8x53	at1_on	0	11.32	No	No	No	Yes	5	5
429	8x53	8x56	at1_on	0	4.51	No	Yes	No	No	5	3
430	Lig	Lig	at1_on	0	30	Yes	Yes	Yes	Yes	0	0
431	1x59	1x60	at1_on	0	3.09	No	No	Yes	Yes	4	4
432	7x54	8x50	at1_on	0	3.01	No	No	No	Yes	7	8
433	1x31	1x35	at1_on	0	2.94	Yes	No	Yes	Yes	3	6
434	4x62	4x63	at1_on	0	2.94	No	No	No	No	5	4
435	6x36	6x40	at1_on	0	2.94	No	No	No	No	8	8
436	1x34	1x35	at1_on	0	2.92	No	No	Yes	Yes	4	6
437	E2.E185	E2.S186	at1_on	0	2.87	No	No	No	No	5	0
438	1x47	2x51	at1_on	0	2.85	Yes	No	No	No	6	7
439	3x54	5x65	at1_on	0	2.85	No	No	No	No	8	8
440	5x61	5x65	at1_on	0	2.85	No	No	No	No	8	8
441	2x44	2x48	at1_on	0	2.77	No	No	No	No	5	5
442	3x41	4x53	at1_on	0	2.77	No	No	No	No	5	8
443	6x31	6x35	at1_on	0	2.77	No	No	No	No	4	5
444	7x51	7x56	at1_on	0	2.77	No	No	No	No	6	7
445	1x53	7x55	at1_on	0	2.62	No	Yes	No	No	9	6
446	2x38	2x42	at1_on	0	2.62	No	No	Yes	Yes	7	7
447	2x38	I2x57	at1_on	0	2.62	No	No	No	Yes	7	6
448	2x49	4x50	at1_on	0	2.59	No	No	Yes	Yes	8	9
449	6x54	7x37	at1_on	0	2.59	No	No	No	No	5	7
450	4x64	5x35	at1_on	0	2.57	No	No	No	No	4	1
451	7x25	7x26	at1_on	0	2.51	No	No	No	No	2	1
452	5x47	5x48	at1_on	0	2.44	Yes	Yes	No	No	8	4
453	5x62	5x63	at1_on	0	2.32	No	Yes	No	No	5	3
454	1x46	7x47	at1_on	0	1.96	No	Yes	No	No	8	8
455	1x45	1x46	at1_on	0	1.84	No	No	No	Yes	5	8
456	5x40	6x59	at1_on	0	1.84	No	No	No	No	5	4
457	2x41	4x46	at1_on	0	1.71	No	Yes	No	No	6	7
458	3x30	4x57	at1_on	0	1.71	No	No	No	No	5	7
459	5x39	5x40	at1_on	0	1.71	No	No	No	No	5	5
460	1x46	1x50	at1_on	0	1.7	No	Yes	No	No	8	9
461	1x54	2x47	at1_on	0	1.7	No	No	No	No	7	8
462	2x37	2x39	at1_on	0	1.68	No	No	No	No	8	7
463	NT.K20	NT.P19	at1_on	0	1.67	No	No	No	Yes	6	4
464	4x60	5x39	at1_on	0	1.64	No	No	No	No	6	5
465	4x41	4x45	at1_on	0	1.59	No	No	No	No	4	5
466	1x40	1x41	at1_on	0	1.55	No	No	No	No	5	5
467	1x37	1x41	at1_on	0	1.52	No	No	No	No	6	5
468	2x38	4x39	at1_on	0	1.52	No	No	No	No	7	1
469	1x48	1x49	at1_on	0	1.51	No	No	No	No	4	7
470	E2.N188	E2.S186	at1_on	0	1.49	No	No	No	No	0	0
471	4x38	4x40	at1_on	0	1.47	Yes	No	No	No	7	4
472	4x47	4x48	at1_on	0	1.47	No	No	No	No	4	3
473	5x56	5x60	at1_on	0	1.47	No	No	No	No	4	3
474	5x67	I3.I228	at1_on	0	1.45	No	No	No	No	4	0
475	8x55	8x59	at1_on	0	1.41	No	No	No	No	3	0
476	8x55	8x58	at1_on	0	1.38	No	No	No	No	3	6
477	I3.E227	I3.I228	at1_on	0	1.37	No	No	No	No	0	0
478	I3.I228	I3.Q229	at1_on	0	1.37	No	No	No	No	0	0
479	5x68	I3.Y226	at1_on	0	1.33	No	No	No	Yes	0	0
480	I3.N231	I3.Q229	at1_on	0	1.32	No	No	No	No	0	0
481	3x52	I2x56	at1_on	0	1.21	No	No	No	No	5	4
482	I2x55	I2x56	at1_on	0	1.21	No	No	No	No	4	4
483	6x29	6x31	at1_on	0	1.19	No	No	No	No	0	4
484	8x59	8x60	at1_on	0	1.19	No	No	No	No	0	0

Orange: nodes, hubs and links specific of at1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of at1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	at1_off Avg Int. Strength	at1_on Avg Int. Strength	at1_off Num Of Links	at1_on Num Of Links	ConSurf
1	1x31	at1_off	3.3125	5.16333	4	3	3
2	1x43	at1_off	6.18625	7.70667	4	3	6
3	1x47	at1_off	3.64	3.14	4	3	6
4	2x53	at1_off	10.975	1.56	5	1	6
5	4x38	at1_off	2.3525	2.32	4	2	7
6	5x44	at1_off	5.03375	3.79	4	2	4
7	5x54	at1_off	6.4225	4.83	4	2	8
8	6x37	at1_off	5.23125	4.75	4	2	7
9	6x44	at1_off	6.75	5.015	5	2	9
10	6x63	at1_off	2.92125	1.49	4	1	1
11	7x30	at1_off	3.657	3.795	5	2	4
12	7x32	at1_off	4.38	3.88	4	3	1
13	7x36	at1_off	2.56	2.94	4	1	6
14	7x42	at1_off	7.492	6.34333	5	3	7
15	7x46	at1_off	11.6112	4.63	4	1	9
16	7x52	at1_off	5.16	7.28	4	2	8
17	1x35	Shared	4.772	3.885	5	6	6
18	1x39	Shared	6.714	5.398	5	5	7
19	1x60	Shared	2.05	6.816	4	5	4
20	2x42	Shared	5.929	5.04	5	5	7
21	2x50	Shared	8.0875	5.61	4	5	9
22	2x57	Shared	4.9	5.73	4	4	8
23	2x60	Shared	9.1275	7.2025	6	4	7
24	2x63	Shared	5.65625	7.5575	4	4	5
25	E1.Y92	Shared	5.685	8.076	5	5	4
26	E1x50	Shared	7.49071	11.054	7	5	9
27	E1x52	Shared	8.826	7.568	5	5	6
28	3x34	Shared	4.918	4.4075	5	4	5
29	3x51	Shared	6.338	7.086	5	5	8
30	4x50	Shared	4.87875	5.7175	4	4	9
31	E2x52	Shared	9.17375	8.0725	4	4	4
32	5x47	Shared	7.84125	5.795	4	4	8
33	5x50	Shared	3.12875	3.1325	4	4	8
34	5x58	Shared	7.3525	5.368	4	5	9
35	6x45	Shared	8.286	8.585	5	4	5
36	6x48	Shared	8.364	4.906	5	5	8
37	6x51	Shared	6.70625	6.46	4	6	6
38	Lig	Shared	11.481	10.8364	10	25	0
39	NT.P19	at1_on	1.39667	3.3125	3	4	4
40	1x28	at1_on	9.16667	7.3075	3	4	4
41	1x46	at1_on	3.42	1.8025	1	4	8
42	1x53	at1_on	5.86667	2.73	3	4	9
43	2x41	at1_on	1.86167	3.2175	3	4	6
44	2x46	at1_on	3.76	4.3125	2	4	9
45	3x37	at1_on	6.30833	5.62	3	5	7
46	I2x57	at1_on	1.6	5.82	1	5	6
47	E2.H183	at1_on	3.075	9.4025	1	4	3
48	E2.Y184	at1_on	8.18833	8.1975	3	4	4
49	5x43	at1_on	4.295	11.98	2	4	5
50	5x62	at1_on	4.945	5.268	2	5	5
51	I3.Y226	at1_on	0	4.6775	0	4	0
52	6x34	at1_on	5.13833	6.678	3	5	6
53	6x43	at1_on	6.89667	7.275	3	4	6
54	6x49	at1_on	2.94667	5.2025	3	4	5
55	7x53	at1_on	7.945	5.706	3	5	9
56	8x50	at1_on	1.41	4.1075	2	4	8
57	8x53	at1_on	2.4125	7.37	2	6	5

Orange: nodes, hubs and links specific of at1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of at1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	at1_off Recurrence	at1_on Recurrence	at1_off Hub1?	at1_on Hub1?	at1_off Hub2?	at1_on Hub2?	ConSurf1	ConSurf2
1	E1x49	E2.I177	at1_off	10.9052	2.1544	No	No	No	No	5	1
2	E2.I172	E2.I177	at1_off	12.8393	0	No	No	No	No	5	1
3	6x61	7x27	at1_off	10.3325	0	No	No	No	No	2	3
4	6x61	7x30	at1_off	11.4863	2.12506	No	No	Yes	No	2	4
5	6x58	7x30	at1_off	18.3195	0	No	No	Yes	No	4	4
6	6x58	6x62	at1_off	20.3321	0	No	No	No	No	4	3
7	6x62	E2.Y184	at1_off	21.2122	3.12767	No	No	No	Yes	3	4
8	E2.Y184	E2x52	at1_off	25.1781	0.173624	No	Yes	Yes	Yes	4	4
9	E2x52	Lig	at1_off	32.1429	8.94285	Yes	Yes	Yes	Yes	4	0
10	2x60	Lig	at1_off	34.6539	4.99597	Yes	Yes	Yes	Yes	7	0
11	2x60	2x63	at1_off	20.7881	0.20786	Yes	Yes	Yes	Yes	7	5
12	2x63	E2.V179	at1_off	18.8094	0	Yes	Yes	No	No	5	3
13	E2.I172	E2.V179	at1_off	16.907	1.06375	No	No	No	No	5	3
14	1x28	1x30	at1_off	24.6352	0.00733622	No	Yes	No	No	4	6
15	1x30	1x31	at1_off	26.3022	1.05397	No	No	Yes	No	6	3
16	1x31	7x35	at1_off	29.9924	0	Yes	No	No	No	3	5
17	1x28	7x32	at1_off	25.1082	2.12017	No	Yes	Yes	No	4	1
18	1x31	7x32	at1_off	28.4421	0	Yes	No	Yes	No	3	1
19	1x28	7x28	at1_off	46.3692	1.05886	No	Yes	No	No	4	4
20	1x35	7x36	at1_off	31.1079	1.06375	Yes	Yes	Yes	No	6	6
21	1x31	7x36	at1_off	27.7189	0	Yes	No	Yes	No	3	6
22	1x39	Lig	at1_off	59.2255	0	Yes	Yes	Yes	Yes	7	0
23	1x39	2x57	at1_off	10.5998	5.14758	Yes	Yes	Yes	Yes	7	8
24	1x43	2x57	at1_off	12.8245	8.32416	Yes	No	Yes	Yes	6	8
25	2x50	7x46	at1_off	27.9691	2.55545	Yes	Yes	Yes	No	9	9
26	2x53	7x46	at1_off	23.4094	0	Yes	No	Yes	No	6	9
27	2x53	7x42	at1_off	13.5201	0	Yes	No	Yes	No	6	7
28	7x42	Lig	at1_off	81.057	0	Yes	No	Yes	Yes	7	0
29	1x53	7x53	at1_off	41.7162	0	No	Yes	No	Yes	9	9
30	2x43	7x53	at1_off	85.7185	0	No	No	No	Yes	8	9
31	2x43	3x46	at1_off	87.5891	1.6482	No	No	No	No	8	9
32	2x42	3x46	at1_off	20.6905	3.29396	Yes	Yes	No	No	7	9
33	2x42	4x46	at1_off	19.1169	0	Yes	Yes	No	No	7	7
34	2x45	4x46	at1_off	19.1127	5.92522	No	No	No	No	9	7
35	3x34	4x57	at1_off	23.087	0	Yes	Yes	No	No	5	7
36	3x33	4x57	at1_off	23.6172	4.233	No	No	No	No	4	7
37	3x33	Lig	at1_off	24.2344	6.32137	No	No	Yes	Yes	4	0
38	3x46	6x37	at1_off	79.0253	0	No	No	Yes	No	9	7
39	5x54	5x58	at1_off	34.8448	0	Yes	No	Yes	Yes	8	9
40	5x54	6x45	at1_off	45.9302	0	Yes	No	Yes	Yes	8	5
41	6x44	6x45	at1_off	81.1334	0	Yes	No	Yes	Yes	9	5
42	6x48	7x42	at1_off	79.7315	0	Yes	Yes	Yes	No	8	7
43	5x58	6x41	at1_off	65.028	1.02952	Yes	Yes	No	No	9	8
44	6x41	6x45	at1_off	33.445	0	No	No	Yes	Yes	8	5
45	3x43	6x41	at1_off	32.6137	0	No	No	No	No	8	8
46	3x43	6x44	at1_off	32.9191	0	No	No	Yes	No	8	9
47	2x40	I1x48	at1_off	16.2093	2.55545	No	No	No	No	8	5
48	2x38	3x49	at1_off	13.8722	0	No	No	No	No	7	8
49	3x49	3x50	at1_off	17.3927	0	No	No	No	No	8	9
50	3x50	6x37	at1_off	20.8538	0	No	No	Yes	No	9	7
51	7x45	7x49	at1_off	17.3821	0	No	No	No	No	9	9
52	7x45	7x46	at1_off	21.1444	0	No	No	Yes	No	9	9
53	6x44	7x45	at1_off	33.9307	0	Yes	No	No	No	9	9
54	3x41	4x49	at1_off	20.8347	0	No	No	No	No	5	7
55	3x42	4x49	at1_off	22.7413	7.68102	No	No	No	No	7	7
56	2x46	3x42	at1_off	24.6437	0	No	Yes	No	No	9	7
57	3x54	6x30	at1_off	19.1699	0	No	No	No	No	8	6
58	6x30	6x31	at1_off	21.3374	0	No	No	No	No	6	4
59	6x31	6x32	at1_off	25.5726	0.00733622	No	No	No	No	4	7
60	6x32	6x35	at1_off	33.4026	0	No	No	No	No	7	5
61	6x35	7x55	at1_off	35.5383	0	No	No	No	No	5	6
62	6x36	7x55	at1_off	39.8096	0	No	No	No	No	8	6
63	6x36	7x53	at1_off	43.7394	0	No	No	No	Yes	8	9
64	3x54	5x61	at1_off	14.8074	0.141834	No	No	No	No	8	8
65	2x38	4x38	at1_off	12.2222	0	No	No	Yes	No	7	7
66	3x41	4x52	at1_off	11.6538	1.09799	No	No	No	No	5	4
67	5x61	6x34	at1_off	12.64	0	No	No	No	Yes	8	6
68	6x60	E3.I271	at1_off	26.4761	1.42323	No	No	No	No	3	1
69	7x26	E3.I271	at1_off	29.8757	4.20365	No	No	No	No	1	1
70	7x23	7x26	at1_off	33.2711	0	No	No	No	No	4	1
71	7x23	7x25	at1_off	36.6623	1.05642	No	No	No	No	4	2
72	7x25	7x28	at1_off	43.4319	0	No	No	No	No	2	4
73	6x60	E3.I270	at1_off	19.6641	1.0662	No	No	No	No	3	2
74	6x63	E3.I270	at1_off	16.2517	0	Yes	No	No	No	1	2
75	1x60	I1x48	at1_off	14.0333	0	Yes	Yes	No	No	4	5
76	1x35	1x39	at1_off	60.3516	0.777639	Yes	Yes	Yes	Yes	6	7
77	2x53	2x57	at1_off	19.5071	0	Yes	No	Yes	Yes	6	8
78	1x35	7x35	Shared	28.4018	10.7304	Yes	Yes	No	No	6	5
79	2x45	4x50	Shared	19.4711	14.2885	No	No	Yes	Yes	9	9
80	3x34	4x50	Shared	20.7754	16.8342	Yes	Yes	Yes	Yes	5	9
81	5x58	6x37	Shared	100	39.9139	Yes	Yes	Yes	No	9	7
82	6x44	6x48	Shared	83.8501	94.3927	Yes	No	Yes	Yes	9	8
83	1x57	2x44	Shared	35.5892	17.8001	No	No	No	No	7	5
84	1x53	1x57	Shared	37.7248	20.3238	No	Yes	No	No	9	7
85	2x44	I1x50	Shared	31.3306	12.7381	No	No	No	No	5	7
86	2x40	I1x50	Shared	20.559	10.1998	No	No	No	No	8	7
87	2x46	2x50	Shared	26.5418	53.5911	No	Yes	Yes	Yes	9	9
88	2x50	7x49	Shared	12.4258	53.4639	Yes	Yes	No	No	9	9
89	2x63	E1x50	at1_on	2.09747	14.4744	Yes	Yes	Yes	Yes	5	9
90	2x63	Lig	at1_on	0	14.939	Yes	Yes	Yes	Yes	5	0
91	E2.H183	Lig	at1_on	0	10.2071	No	Yes	Yes	Yes	3	0
92	NT.D16	NT.P19	at1_on	0	12.4691	No	No	No	Yes	0	4
93	Lig	NT.D16	at1_on	0	13.4766	Yes	Yes	No	No	0	0
94	7x35	Lig	at1_on	0	11.5521	No	No	Yes	Yes	5	0
95	2x57	7x42	at1_on	0	11.2244	Yes	Yes	Yes	No	8	7
96	3x36	7x42	at1_on	0	10.4199	No	No	Yes	No	7	7
97	3x36	Lig	at1_on	0	80.9845	No	No	Yes	Yes	7	0
98	1x50	2x50	at1_on	7.78546	100	No	No	Yes	Yes	9	9
99	2x46	7x53	at1_on	0	54.5986	No	Yes	No	Yes	9	9
100	3x50	7x53	at1_on	0	55.2784	No	No	No	Yes	9	9
101	3x50	5x58	at1_on	0	55.6257	No	No	Yes	Yes	9	9
102	3x47	5x58	at1_on	1.81753	95.0089	No	No	Yes	Yes	9	9
103	3x47	5x54	at1_on	6.45996	94.6715	No	No	Yes	No	9	8
104	5x54	6x44	at1_on	0	94.5174	Yes	No	Yes	No	8	9
105	3x36	6x48	at1_on	1.10918	86.3326	No	No	Yes	Yes	7	8
106	7x49	7x53	at1_on	0	54.5815	No	No	No	Yes	9	9
107	6x40	7x53	at1_on	0	55.99	No	No	No	Yes	8	9
108	5x58	6x40	at1_on	0	57.4646	Yes	Yes	No	No	9	8
109	1x50	7x50	at1_on	3.90015	80.965	No	No	No	No	9	9
110	1x53	7x55	at1_on	0	46.8882	No	Yes	No	No	9	6
111	1x53	7x50	at1_on	0	73.7461	No	Yes	No	No	9	9
112	1x60	8x53	at1_on	5.79615	22.1529	Yes	Yes	No	Yes	4	5
113	8x50	8x53	at1_on	0	32.1767	No	Yes	No	Yes	8	5
114	7x55	8x50	at1_on	0	39.6718	No	No	No	Yes	6	8
115	3x34	4x53	at1_on	0.871649	21.0892	Yes	Yes	No	No	5	8
116	3x41	4x53	at1_on	0	21.9671	No	No	No	No	5	8
117	3x37	3x41	at1_on	7.36978	23.7229	No	Yes	No	No	7	5
118	3x37	Lig	at1_on	0	25.6156	No	Yes	Yes	Yes	7	0
119	2x42	4x45	at1_on	1.04131	11.3345	Yes	Yes	No	No	7	5
120	2x38	I2x57	at1_on	0	13.1734	No	No	No	Yes	7	6
121	3x51	5x61	at1_on	0	27.2125	Yes	Yes	No	No	8	8
122	5x61	5x65	at1_on	0	27.8458	No	No	No	No	8	8
123	5x65	6x34	at1_on	0	29.4647	No	No	No	Yes	8	6
124	5x62	6x34	at1_on	6.06973	35.2897	No	Yes	No	Yes	5	6
125	5x62	6x37	at1_on	0	39.2268	No	Yes	Yes	No	5	7
126	3x52	I2x57	at1_on	0	21.2066	No	No	No	Yes	5	6
127	6x48	6x52	at1_on	0	13.2688	Yes	Yes	No	No	8	8
128	1x46	1x50	at1_on	0	17.8001	No	Yes	No	No	8	9
129	1x45	1x46	at1_on	0	10.1998	No	No	No	Yes	5	8
130	3x51	3x52	at1_on	0.771972	21.7935	Yes	Yes	No	No	8	5

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
NT.K20	NT.R23	at1_off	4.335	0	0	0	2	1
7x31	NT.A21	Shared	4.63	4.63	0	1	1	2
1x32	NT.R23	at1_off	5.34	0	1	0	2	1
E1.Y92	NT.R23	Shared	6.175	7.2	1	1	1	1
1x32	E1.Y92	Shared	6.705	4.13	1	0	2	1
1x35	1x39	Shared	7.25	6.04	0	0	2	1
1x35	2x64	at1_off	8.36	0	0	0	2	2
1x35	7x35	Shared	3.39	5.08	0	0	2	1
1x39	2x57	Shared	7.615	8.21	0	0	1	2
1x39	2x61	Shared	3.335	2.67	0	0	1	2
1x39	7x39	Shared	5.375	4.03	0	0	1	2
1x39	Lig	at1_off	9.995	0	0	0	1	0
2x53	2x57	at1_off	6.7	0	1	0	2	2
2x53	3x32	at1_off	6.55	0	1	0	2	1
2x53	3x35	Shared	13.29	1.56	1	0	2	2
2x53	7x42	at1_off	14.44	0	1	0	2	1
2x60	2x63	Shared	4.82	3.86	1	1	1	1
2x60	E1x50	at1_off	10.31	0	1	1	1	2
2x60	3x28	Shared	3.89	3.89	1	1	1	2
2x60	3x29	at1_off	4.94	0	1	1	1	1
2x60	E2x50	at1_off	3.265	0	1	1	1	2
2x60	Lig	Shared	27.54	16.21	1	1	1	0
2x63	E1.Y92	Shared	6.45	10.92	1	1	1	1
2x63	E1x50	Shared	8.2	10.61	1	1	1	2
2x63	E2.V179	at1_off	3.155	0	1	1	1	1
2x64	E1.Y92	Shared	5.62	7.49	0	0	2	1
7x35	E1.Y92	at1_off	3.475	0	0	1	1	1
E1x50	E2x50	Shared	11.1	15.67	1	1	2	2
3x29	4x65	Shared	13.835	15.81	1	0	1	1
3x29	Lig	at1_off	3.345	0	1	0	1	0
3x32	7x42	Shared	5.05	3.79	1	1	1	1
3x32	Lig	Shared	15.23	3.93	1	1	1	0
3x33	4x57	Shared	3.26	6.52	0	1	1	2
3x33	Lig	Shared	13.42	5.28	0	1	1	0
3x35	7x42	at1_off	6.975	0	1	0	2	1
3x36	6x48	Shared	13.67	3.42	0	1	1	2
3x37	3x41	Shared	3.61	6.19	0	1	1	2
3x37	4x56	Shared	9.34	8.01	0	1	1	2
3x37	5x43	Shared	5.975	4.78	0	1	1	1
4x64	E2x52	at1_off	14.71	0	0	0	2	1
4x65	E2x52	Shared	3.21	17.1	1	0	1	1
4x65	Lig	at1_off	24.47	0	1	0	1	0
E2.I172	E2.V179	Shared	5.375	3.07	0	0	2	1
E2.Y184	E2x52	Shared	12.895	4.13	0	1	1	1
E2x52	Lig	Shared	5.88	6.19	1	1	1	0
6x62	E2.Y184	Shared	9.585	12.4	0	0	2	1
5x39	5x42	at1_off	3.685	0	0	0	2	2
6x48	6x51	at1_off	3.175	0	0	0	2	1
6x48	7x42	at1_off	7.235	0	0	0	2	1
6x51	6x55	Shared	5.475	6.85	0	1	1	2
6x51	7x37	Shared	8.895	8.21	0	1	1	2
6x51	7x38	Shared	9.28	3.98	0	1	1	1
6x58	6x62	at1_off	9.14	0	0	0	1	2
6x58	7x34	at1_off	5.545	0	0	0	1	1
6x61	7x27	at1_off	3.25	0	0	1	1	2
6x61	7x30	Shared	4.61	4.61	0	1	1	2
7x38	Lig	Shared	9.15	6.41	0	1	1	0
7x42	Lig	at1_off	3.76	0	1	0	1	0
E2.E185	E2.H183	Shared	3.075	4.92	0	0	2	1
E3.R272	NT.D17	at1_off	2.98	0	0	0	2	1
6x58	7x30	at1_off	2.92	0	0	0	1	2
7x30	7x31	at1_off	2.92	0	0	0	2	1
5x40	5x43	at1_off	2.615	0	0	0	2	1
1x31	7x35	at1_off	2.54	0	3	4	2	1
4x64	E2.E185	at1_off	2.46	0	0	0	2	2
5x36	E2.Y184	Shared	2.085	4.17	0	0	2	1
4x61	Lig	at1_off	2.02	0	0	0	1	0
3x30	4x61	at1_off	1.79	0	0	0	2	1
2x56	3x28	at1_off	1.68	0	0	0	2	2
NT.D17	NT.S16	at1_off	1.47	0	0	0	1	2
NT.P19	NT.S16	at1_off	0.89	0	0	0	2	2
E2.V179	E2x51	at1_off	0.85	0	0	1	1	1
E2.F170	NT.I14	at1_on	0	10.05	0	1	2	2
E2.H183	NT.I14	at1_on	0	13.26	0	1	1	2
NT.D16	NT.P19	at1_on	0	6.44	0	1	1	2
Lig	NT.D16	at1_on	0	7.25	1	1	0	1
Lig	NT.D17	at1_on	0	4.22	1	1	0	1
Lig	NT.R23	at1_on	0	3.76	1	1	0	1
1x39	7x38	at1_on	0	6.04	0	0	1	1
2x56	2x60	at1_on	0	4.85	0	0	2	1
2x57	7x42	at1_on	0	8.21	0	0	2	1
2x63	Lig	at1_on	0	4.84	1	1	1	0
E1.Y92	Lig	at1_on	0	10.64	1	1	1	0
3x33	4x61	at1_on	0	3.42	0	1	1	1
3x36	7x42	at1_on	0	7.03	0	1	1	1
3x36	Lig	at1_on	0	4.87	0	1	1	0
3x37	5x42	at1_on	0	4.99	0	1	1	2
3x37	Lig	at1_on	0	4.13	0	1	1	0
4x64	5x36	at1_on	0	4.58	0	0	2	2
E2.F170	E2.H183	at1_on	0	3.39	0	1	2	1
E2.V179	Lig	at1_on	0	4.67	0	1	1	0
E2x51	Lig	at1_on	0	4.95	0	0	1	0
5x39	E2x52	at1_on	0	4.87	0	0	2	1
E2.H183	Lig	at1_on	0	16.04	0	1	1	0
E2.Y184	Lig	at1_on	0	12.09	0	1	1	0
5x43	6x51	at1_on	0	7.86	0	1	1	1
5x43	6x55	at1_on	0	10.51	0	1	1	2
5x43	Lig	at1_on	0	24.77	0	1	1	0
6x51	7x34	at1_on	0	3.94	0	1	1	1
6x51	Lig	at1_on	0	7.92	0	1	1	0
6x58	Lig	at1_on	0	14.05	0	0	1	0
6x61	E3.I271	at1_on	0	5.89	0	1	1	2
6x61	Lig	at1_on	0	5.01	0	1	1	0
7x31	Lig	at1_on	0	22.07	0	1	1	0
7x34	Lig	at1_on	0	13.98	0	1	1	0
7x35	Lig	at1_on	0	7.63	0	1	1	0
1x31	1x35	at1_on	0	2.94	3	4	2	2
3x30	4x57	at1_on	0	1.71	0	0	2	2
5x39	5x40	at1_on	0	1.71	0	0	2	2
NT.K20	NT.P19	at1_on	0	1.67	0	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	at1_off	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
	at1_on	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2

Network Difference
Value	at1_off	at1_on
I_min	3.12	3.26
Number of Linked Nodes	281	289
Number of Specific Nodes	20 (7.12%)	28 (9.69%)
Number of Shared Nodes	261 (92.88%)	261 (90.31%)
Number of Links	312	325
Number of Specific Links	159 (50.96%)	172 (52.92%)
Number of Shared Links	153 (49.04%)	153 (47.08%)
Number of Hubs	38	41
Number of Specific Hubs	16 (42.11%)	19 (46.34%)
Number of Shared Hubs	22 (57.89%)	22 (53.66%)
Average % Shared Neighbours (Jaccard)	33.81
Average % Shared Neighbours (Otsuka)	43.30
Average % Shared Neighbours (Overlap Coefficient)	53.14
Average % Shared Cliques (k3-6)	76.06
Graphlets Similarity	0.58362

Paths Difference
Value	at1_off	at1_on
Number Of Nodes in MetaPath	81	53
Specific Nodes in MetaPath	50 (61.73%)	22 (41.51%)
Shared Nodes in MetaPath	261 (92.88%)	261 (92.88%)
Number Of Links MetaPath	88	53
Specific Links in MetaPath	77 (87.50%)	42 (79.25%)
Shared Links in MetaPath	153 (49.04%)	153 (49.04%)
Number of Shortest Paths	97674	77451
Length Of Smallest Path	3	3
Average Path Length	17.139	15.2114
Length of Longest Path	39	33
Minimum Path Strength	0.745	1.21
Average Path Strength	6.44623	5.55663
Maximum Path Strength	21.385	23.42
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.914387	0.934925
Maximum Path Correlation	0.985	1
Minimum % Of Corr. Nodes	2.7027	4.34783
Average % Of Corr. Nodes	33.0347	50.1002
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	43.1616	41.8676
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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