psnGPCR

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Orange: nodes, hubs and links specific of bb2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of bb2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	bb2_off Int. Strength	bb2_on Int. Strength	bb2_off Hub1?	bb2_on Hub1?	bb2_off Hub2?	bb2_on Hub2?	ConSurf1	ConSurf2
1	1x31	1x34	bb2_off	6.14	0	No	No	No	No	4	5
2	1x36	2x64	bb2_off	9.74	0	No	No	Yes	Yes	6	4
3	1x39	1x43	bb2_off	10.88	0	Yes	Yes	Yes	No	7	7
4	1x42	7x42	bb2_off	6.28	0	No	No	Yes	Yes	7	7
5	1x43	2x54	bb2_off	4.28	0	Yes	No	No	No	7	6
6	1x43	7x42	bb2_off	7.54	0	Yes	No	Yes	Yes	7	7
7	1x49	7x50	bb2_off	4.06	0	No	No	No	No	8	9
8	1x50	2x47	bb2_off	4.69	0	Yes	No	No	No	9	9
9	1x50	2x51	bb2_off	5.49	0	Yes	No	No	No	9	8
10	1x51	2x51	bb2_off	4.28	0	No	No	No	No	4	8
11	1x53	8x50	bb2_off	7.31	0	No	No	Yes	No	9	9
12	1x54	2x44	bb2_off	6.19	0	No	No	No	No	7	5
13	1x57	2x41	bb2_off	4.87	0	No	No	No	No	7	6
14	2x38	2x42	bb2_off	3.93	0	Yes	No	Yes	Yes	7	7
15	2x38	4x42	bb2_off	5.09	0	Yes	No	No	No	7	7
16	2x39	3x49	bb2_off	6.44	0	No	No	No	No	8	8
17	2x39	6x33	bb2_off	6.57	0	No	No	No	No	8	8
18	2x42	3x42	bb2_off	3.89	0	Yes	Yes	Yes	No	7	8
19	2x45	4x50	bb2_off	4.94	0	No	No	Yes	No	9	9
20	2x52	3x31	bb2_off	4.28	0	No	No	No	No	7	5
21	2x551	3x28	bb2_off	4.56	0	No	No	No	Yes	5	5
22	2x58	E1x52	bb2_off	4.33	0	No	No	No	Yes	9	7
23	2x62	E1x52	bb2_off	3.96	0	No	No	No	Yes	4	7
24	E1.D104	E2.E186	bb2_off	10.39	0	No	No	Yes	Yes	4	3
25	E1x49	E2.F193	bb2_off	4.28	0	No	No	No	Yes	4	1
26	E1x50	E2.L181	bb2_off	4.56	0	Yes	Yes	Yes	No	8	4
27	3x22	E2.L181	bb2_off	6.07	0	No	No	Yes	No	4	4
28	3x26	E2.D180	bb2_off	9.68	0	No	No	No	No	7	4
29	3x27	3x31	bb2_off	7.14	0	No	No	No	No	5	5
30	3x30	3x34	bb2_off	3.89	0	Yes	Yes	No	No	6	5
31	3x33	4x57	bb2_off	4.73	0	No	No	No	No	4	7
32	3x33	4x61	bb2_off	9.28	0	No	No	Yes	Yes	4	5
33	3x36	6x48	bb2_off	4.9	0	No	No	Yes	Yes	7	8
34	3x39	6x44	bb2_off	7.44	0	Yes	No	No	No	9	9
35	3x39	7x45	bb2_off	9.79	0	Yes	No	Yes	Yes	9	9
36	3x39	7x46	bb2_off	4.59	0	Yes	No	Yes	No	9	8
37	3x40	6x44	bb2_off	6.55	0	No	No	No	No	8	9
38	3x41	5x46	bb2_off	4.29	0	Yes	No	No	Yes	5	6
39	3x42	4x49	bb2_off	4.56	0	Yes	No	No	No	8	7
40	3x46	6x37	bb2_off	7.45	0	No	No	No	No	9	8
41	3x49	3x50	bb2_off	5.96	0	No	No	Yes	Yes	8	9
42	3x50	3x53	bb2_off	4.15	0	Yes	Yes	No	No	9	8
43	3x50	6x33	bb2_off	13.36	0	Yes	Yes	No	No	9	8
44	3x50	6x37	bb2_off	3.92	0	Yes	Yes	No	No	9	8
45	3x53	6x30	bb2_off	4.53	0	No	No	No	No	8	7
46	3x56	I2x51	bb2_off	6.2	0	No	No	No	No	6	5
47	I2x54	I2x57	bb2_off	4.95	0	No	No	No	No	5	7
48	4x60	4x64	bb2_off	4.33	0	No	No	No	No	7	5
49	4x65	E2x52	bb2_off	5.34	0	No	No	No	No	5	4
50	E2.I194	E2.L181	bb2_off	4.28	0	No	No	Yes	No	4	4
51	E2.E187	E2.H185	bb2_off	4.92	0	No	No	No	No	4	2
52	E2.Q191	E2.T189	bb2_off	5.67	0	No	No	No	No	2	1
53	E2.F193	E2.Q191	bb2_off	15.23	0	No	Yes	No	No	1	2
54	6x58	E2.Y199	bb2_off	4.12	0	No	No	Yes	Yes	4	5
55	E2.Y199	Lig	bb2_off	13.06	0	Yes	Yes	Yes	Yes	5	0
56	5x29	E3.S292	bb2_off	9.76	0	No	No	No	No	3	1
57	5x35	E3.Y291	bb2_off	6.95	0	No	No	Yes	Yes	3	1
58	5x35	Lig	bb2_off	8.23	0	No	No	Yes	Yes	3	0
59	5x38	Lig	bb2_off	7.16	0	Yes	No	Yes	Yes	6	0
60	5x39	6x60	bb2_off	3.82	0	No	No	No	No	5	5
61	5x47	5x51	bb2_off	8.21	0	Yes	No	No	No	8	6
62	5x53	5x57	bb2_off	3.63	0	No	No	No	No	7	7
63	5x58	6x38	bb2_off	14.07	0	Yes	Yes	No	No	8	5
64	5x65	6x31	bb2_off	4.23	0	No	No	No	No	8	5
65	6x26	6x30	bb2_off	12.74	0	No	No	No	No	3	7
66	6x39	7x56	bb2_off	5.96	0	No	No	No	No	6	7
67	6x40	7x53	bb2_off	8.53	0	No	No	No	No	7	9
68	6x43	7x45	bb2_off	4.12	0	No	No	Yes	Yes	7	9
69	6x47	7x45	bb2_off	4.72	0	No	No	Yes	Yes	8	9
70	6x48	6x51	bb2_off	4.52	0	Yes	Yes	Yes	No	8	5
71	6x48	7x41	bb2_off	6.48	0	Yes	Yes	No	No	8	8
72	6x51	7x37	bb2_off	4.69	0	Yes	No	No	No	5	6
73	6x61	E3.E293	bb2_off	8.62	0	No	No	No	No	2	5
74	7x30	7x33	bb2_off	4.11	0	No	Yes	No	No	4	4
75	7x53	8x50	bb2_off	13.4	0	No	No	Yes	No	9	9
76	6x40	7x49	bb2_off	3.62	0	No	No	No	Yes	7	9
77	1x32	2x64	bb2_off	3.52	0	No	No	Yes	Yes	4	4
78	1x42	7x47	bb2_off	3.27	0	No	No	No	No	7	7
79	5x68	6x27	bb2_off	3.1	0	No	No	No	No	6	4
80	1x56	1x60	bb2_off	3.07	0	No	No	Yes	No	7	6
81	5x68	6x31	bb2_off	3.06	0	No	No	No	No	6	5
82	2x38	4x39	bb2_off	2.98	0	Yes	No	No	No	7	2
83	2x59	2x60	bb2_off	2.92	0	No	Yes	No	Yes	6	6
84	6x26	6x29	bb2_off	2.89	0	No	No	No	No	3	5
85	4x52	4x55	bb2_off	2.85	0	No	No	No	No	4	4
86	5x40	5x44	bb2_off	2.83	0	No	No	No	No	4	4
87	2x49	4x50	bb2_off	2.81	0	No	No	Yes	No	8	9
88	3x24	E1x50	bb2_off	2.81	0	No	No	Yes	Yes	6	8
89	5x63	5x64	bb2_off	2.8	0	No	No	No	No	3	5
90	2x42	4x46	bb2_off	2.77	0	Yes	Yes	No	No	7	7
91	6x25	6x28	bb2_off	2.7	0	No	No	No	No	4	4
92	1x39	2x57	bb2_off	2.67	0	Yes	Yes	No	No	7	7
93	5x47	6x45	bb2_off	2.67	0	Yes	No	No	No	8	6
94	5x58	6x34	bb2_off	2.67	0	Yes	Yes	No	No	8	6
95	E3.S292	E3.Y291	bb2_off	2.54	0	No	No	Yes	Yes	1	1
96	E2.E186	E2.F184	bb2_off	2.33	0	Yes	Yes	No	Yes	3	2
97	6x42	6x45	bb2_off	1.95	0	No	No	No	No	5	6
98	5x28	Lig	bb2_off	1.83	0	No	No	Yes	Yes	5	0
99	1x54	1x58	bb2_off	1.64	0	No	No	No	No	7	3
100	5x28	5x31	bb2_off	1.63	0	No	No	No	No	5	2
101	5x55	5x56	bb2_off	1.62	0	No	No	No	No	5	4
102	3x26	4x62	bb2_off	1.61	0	No	No	No	No	7	5
103	E3.T296	E3.V294	bb2_off	1.59	0	No	No	No	No	3	5
104	7x43	7x48	bb2_off	1.59	0	No	No	No	No	5	6
105	2x66	E1x51	bb2_off	1.58	0	No	No	No	No	4	3
106	6x43	7x52	bb2_off	1.58	0	No	No	No	No	7	8
107	1x55	1x59	bb2_off	1.5	0	No	No	No	No	4	5
108	5x30	5x31	bb2_off	1.49	0	No	No	No	No	3	2
109	3x52	4x45	bb2_off	1.44	0	No	No	No	No	4	6
110	I2x54	I2x56	bb2_off	1.44	0	No	No	No	No	5	5
111	1x31	1x32	bb2_off	1.43	0	No	No	No	No	4	4
112	6x35	7x56	bb2_off	1.41	0	No	No	No	No	6	7
113	I2x53	I2x54	bb2_off	1.37	0	No	No	No	No	6	5
114	6x32	8x49	bb2_off	1.32	0	No	No	No	No	8	6
115	I1x48	I1x51	bb2_off	1.24	0	No	No	No	No	5	7
116	7x39	7x42	bb2_off	1.22	0	No	No	Yes	Yes	5	7
117	2x64	2x65	bb2_off	1.17	0	Yes	Yes	No	No	4	4
118	1x35	2x64	Shared	9.67	3.025	No	No	Yes	Yes	6	4
119	1x39	2x60	Shared	12.64	5.175	Yes	Yes	No	Yes	7	6
120	1x39	7x42	Shared	14.44	4.13	Yes	Yes	Yes	Yes	7	7
121	1x44	1x48	Shared	7.14	5.71	No	No	No	No	5	5
122	1x45	7x51	Shared	5.02	2.51	No	No	No	No	6	5
123	1x50	2x50	Shared	5.39	6.73	Yes	No	Yes	Yes	9	9
124	1x50	7x50	Shared	11.4	4.89	Yes	No	No	No	9	9
125	1x52	8x54	Shared	11.67	14.27	No	No	Yes	Yes	7	7
126	1x53	2x43	Shared	4.28	4.28	No	No	No	No	9	8
127	1x55	8x57	Shared	13.56	7.46	No	No	No	No	4	5
128	1x56	8x57	Shared	4.12	8.235	No	No	No	No	7	5
129	1x57	I1x51	Shared	4.28	14.97	No	No	No	No	7	7
130	1x57	2x44	Shared	5.28	9.25	No	No	No	No	7	5
131	1x60	I1x50	Shared	6.09	8.37	Yes	No	No	No	6	7
132	2x40	I1x50	Shared	4.21	4.21	No	No	No	No	8	7
133	2x37	2x39	Shared	8.15	11.4	No	No	No	No	8	8
134	2x37	2x40	Shared	13.62	8.17	No	No	No	No	8	8
135	2x38	3x49	Shared	8.76	4.38	Yes	No	No	No	7	8
136	2x42	3x45	Shared	6.93	4.16	Yes	Yes	No	No	7	7
137	2x42	3x46	Shared	7.31	2.44	Yes	Yes	No	No	7	9
138	2x42	4x45	Shared	6.2	5.58	Yes	Yes	No	No	7	6
139	2x45	3x42	Shared	4.8	6.4	No	No	Yes	No	9	8
140	2x46	3x42	Shared	7.37	2.95	No	Yes	Yes	No	9	8
141	2x46	3x43	Shared	4.15	6.92	No	Yes	No	No	9	9
142	2x48	4x50	Shared	6.83	3.42	No	No	Yes	No	7	9
143	2x50	3x39	Shared	11.06	5.89	Yes	Yes	Yes	No	9	9
144	2x50	7x46	Shared	10.31	10.31	Yes	Yes	Yes	No	9	8
145	2x50	7x49	Shared	5.39	6.73	Yes	Yes	No	Yes	9	9
146	2x53	3x35	Shared	6.01	3	No	Yes	No	No	7	8
147	2x53	7x46	Shared	4.5	4.5	No	Yes	Yes	No	7	8
148	2x54	7x46	Shared	4.5	7.51	No	No	Yes	No	6	8
149	2x551	3x31	Shared	4.56	4.56	No	No	No	No	5	5
150	2x56	3x32	Shared	4.58	10.68	No	Yes	No	Yes	7	6
151	2x57	2x58	Shared	3.74	1.87	No	No	No	No	7	9
152	2x63	E1x50	Shared	6	5	No	No	Yes	Yes	5	8
153	E1x49	E1x51	Shared	7.29	5.465	No	No	No	No	4	3
154	E1x50	E1x52	Shared	15.03	15.03	Yes	Yes	No	Yes	8	7
155	3x25	E1x50	Shared	3.92	5.22	No	No	Yes	Yes	9	8
156	E1x50	E2x50	Shared	6.53	17.63	Yes	Yes	No	No	8	9
157	3x22	E2.D180	Shared	13.1	13.1	No	No	No	No	4	4
158	3x25	E2.L181	Shared	4.76	3.17	No	No	Yes	No	9	4
159	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
160	3x28	3x32	Shared	4.12	4.12	No	Yes	No	Yes	5	6
161	3x29	4x61	Shared	6.29	3.145	No	Yes	Yes	Yes	5	5
162	3x29	4x65	Shared	5.34	6.235	No	Yes	No	No	5	5
163	3x29	Lig	Shared	10.97	15.255	No	Yes	Yes	Yes	5	0
164	3x30	4x54	Shared	6.22	3.73	Yes	Yes	No	No	6	4
165	3x30	4x57	Shared	4.16	5.545	Yes	Yes	No	No	6	7
166	3x30	4x59	Shared	3.77	4.395	Yes	Yes	No	No	6	4
167	3x32	Lig	Shared	10.38	4.54	No	Yes	Yes	Yes	6	0
168	3x34	4x54	Shared	7.53	9.035	No	No	No	No	5	4
169	3x37	3x41	Shared	6.02	3.01	No	Yes	Yes	No	6	5
170	3x37	4x53	Shared	3.71	3.71	No	Yes	No	No	6	8
171	3x38	4x50	Shared	15.94	19.615	No	No	Yes	No	7	9
172	3x40	3x41	Shared	3.93	7.87	No	No	Yes	No	8	5
173	3x40	5x50	Shared	5.3	5.3	No	No	No	No	8	9
174	3x41	4x49	Shared	6.28	3.77	Yes	No	No	No	5	7
175	3x44	5x54	Shared	6.08	3.8	No	No	No	No	7	8
176	3x47	5x54	Shared	10.84	7.74	No	No	No	No	9	8
177	3x47	5x58	Shared	5.09	12.085	No	No	Yes	Yes	9	8
178	3x48	5x57	Shared	5.34	5.34	No	No	No	No	7	7
179	3x51	3x55	Shared	17.66	12.62	Yes	Yes	No	No	8	7
180	3x51	5x57	Shared	8.94	12.41	Yes	Yes	No	No	8	7
181	3x51	5x60	Shared	4.13	4.13	Yes	Yes	No	Yes	8	3
182	3x51	5x61	Shared	3.63	3.63	Yes	Yes	No	Yes	8	8
183	3x55	5x64	Shared	8.87	8.87	No	No	No	No	7	5
184	4x48	4x52	Shared	3.77	7.535	No	No	No	No	3	4
185	4x56	5x46	Shared	3.65	4.26	No	No	No	Yes	6	6
186	4x61	5x38	Shared	3.69	7.39	Yes	Yes	Yes	No	5	6
187	4x61	Lig	Shared	16.23	4.925	Yes	Yes	Yes	Yes	5	0
188	E2.H182	E2x51	Shared	4.39	5.12	No	Yes	No	No	1	1
189	E2.H185	E2.N190	Shared	8.93	1.915	No	No	No	No	2	3
190	E2.E186	E2.S188	Shared	10.06	4.31	Yes	Yes	No	No	3	3
191	E2.E186	E2.T189	Shared	8.47	15.52	Yes	Yes	No	No	3	1
192	E2.Y199	E2x52	Shared	5.56	13.91	Yes	Yes	No	No	5	4
193	E2x52	Lig	Shared	15.54	17.935	No	No	Yes	Yes	4	0
194	E2.Y199	E3.Y291	Shared	11.91	15.885	Yes	Yes	Yes	Yes	5	1
195	5x32	E3.Y291	Shared	16.83	0.56	No	No	Yes	Yes	1	1
196	5x33	5x37	Shared	5.71	4.28	No	No	No	No	1	4
197	5x36	6x60	Shared	16.72	13.14	No	No	No	No	3	5
198	5x38	5x42	Shared	4.18	6.97	Yes	No	No	No	6	6
199	5x38	6x55	Shared	6.53	4.9	Yes	No	Yes	Yes	6	5
200	5x39	6x56	Shared	9.01	3	No	No	No	No	5	5
201	5x39	6x59	Shared	6.52	6.52	No	No	No	No	5	4
202	5x42	6x55	Shared	7.63	3.18	No	No	Yes	Yes	6	5
203	5x43	5x47	Shared	8.25	8.25	No	Yes	Yes	No	6	8
204	5x43	5x48	Shared	6.55	3.275	No	Yes	No	No	6	5
205	5x43	6x52	Shared	6.79	9.615	No	Yes	No	Yes	6	7
206	5x44	5x48	Shared	4.47	3.725	No	No	No	No	4	5
207	5x45	5x46	Shared	5.24	4.59	No	No	No	Yes	5	6
208	5x47	6x49	Shared	9.38	5.86	Yes	No	No	No	8	6
209	5x47	6x52	Shared	7.62	5.44	Yes	No	No	Yes	8	7
210	5x54	6x41	Shared	6.14	3.84	No	No	No	No	8	7
211	5x58	5x61	Shared	12.09	3.63	Yes	Yes	No	Yes	8	8
212	5x58	6x37	Shared	5.05	8.2	Yes	Yes	No	No	8	8
213	5x59	5x60	Shared	9.28	5.16	No	No	No	Yes	3	3
214	6x36	6x40	Shared	3.89	2.59	No	No	No	No	8	7
215	6x36	7x56	Shared	10.32	10.32	No	No	No	No	8	7
216	6x44	6x48	Shared	14.03	13.03	No	No	Yes	Yes	9	8
217	6x46	7x40	Shared	6.09	6.7	No	No	No	No	6	8
218	6x47	7x40	Shared	4.76	3.965	No	No	No	No	8	8
219	6x48	Lig	Shared	8.24	4.03	Yes	Yes	Yes	Yes	8	0
220	6x51	7x41	Shared	4.69	5.47	Yes	No	No	No	5	8
221	6x51	Lig	Shared	4.59	8.165	Yes	No	Yes	Yes	5	0
222	6x52	Lig	Shared	6.44	5.09	No	Yes	Yes	Yes	7	0
223	6x54	7x33	Shared	4.56	3.04	No	No	No	No	5	4
224	6x55	6x59	Shared	5.09	6.995	Yes	Yes	No	No	5	4
225	6x55	Lig	Shared	26.11	5.65	Yes	Yes	Yes	Yes	5	0
226	6x57	6x61	Shared	28.31	6.53	No	No	No	No	4	2
227	7x27	E3.D295	Shared	7.36	5.89	No	No	No	No	3	1
228	7x30	E3.D295	Shared	8.82	3.15	No	Yes	No	No	4	1
229	7x30	7x34	Shared	6.97	6.97	No	Yes	No	No	4	4
230	7x31	7x35	Shared	10.05	7.54	No	Yes	No	No	4	4
231	7x38	Lig	Shared	10.15	11.745	No	Yes	Yes	Yes	5	0
232	7x45	7x49	Shared	8.17	10.9	Yes	Yes	No	Yes	9	9
233	7x54	8x51	Shared	11.32	11.835	Yes	Yes	No	No	7	8
234	7x54	8x54	Shared	9.28	8.765	Yes	Yes	Yes	Yes	7	7
235	7x54	8x55	Shared	5.81	5.81	Yes	Yes	No	No	7	4
236	8x47	8x49	Shared	4.89	4.89	No	No	No	No	8	6
237	8x48	8x51	Shared	4.95	1.855	No	No	No	No	4	8
238	8x50	8x54	Shared	8.57	4.29	Yes	No	Yes	Yes	9	7
239	8x54	8x58	Shared	6.09	4.87	Yes	Yes	No	No	7	7
240	1x48	1x49	Shared	3.53	3.53	No	No	No	No	5	8
241	4x59	4x60	Shared	3.39	3.39	No	No	No	No	4	7
242	5x49	5x50	Shared	3.39	3.39	No	No	No	No	5	9
243	6x49	6x50	Shared	3.28	2.46	No	No	No	No	6	9
244	1x54	2x47	Shared	3.25	2.435	No	No	No	No	7	9
245	1x60	I1x49	Shared	3.23	3.23	Yes	No	No	No	6	6
246	1x60	8x53	Shared	2.87	2.87	Yes	No	No	No	6	6
247	E3.E293	E3.S292	Shared	2.87	5.75	No	No	No	No	5	1
248	1x43	1x47	Shared	2.85	2.85	Yes	No	No	No	7	6
249	3x54	5x65	Shared	2.85	2.85	No	No	No	No	8	8
250	4x51	4x55	Shared	2.85	0.715	No	No	No	No	5	4
251	4x52	4x56	Shared	2.85	2.14	No	No	No	No	4	6
252	5x61	5x65	Shared	2.85	2.85	No	Yes	No	No	8	8
253	5x40	6x56	Shared	2.83	3.535	No	No	No	No	4	5
254	3x21	E1x50	Shared	2.81	2.81	No	No	Yes	Yes	8	8
255	E2.F184	E2.S195	Shared	2.64	4.62	No	Yes	No	No	2	4
256	8x47	8x50	Shared	2.64	2.64	No	No	Yes	No	8	9
257	4x40	I2x57	Shared	2.63	3.94	No	No	No	No	3	7
258	5x56	5x60	Shared	2.62	3.275	No	No	No	Yes	4	3
259	E2.D180	E2.H182	Shared	2.52	5.04	No	No	No	Yes	4	1
260	6x54	6x58	Shared	2.51	6.26	No	No	No	No	5	4
261	7x54	7x55	Shared	2.34	1.76	Yes	Yes	No	No	7	6
262	4x64	5x34	Shared	2.26	12.445	No	No	No	Yes	5	1
263	1x46	7x47	Shared	1.96	1.96	No	No	No	No	8	7
264	1x40	1x43	Shared	1.76	3.53	No	No	Yes	No	4	7
265	1x45	1x46	Shared	1.76	1.76	No	No	No	No	6	8
266	3x23	3x24	Shared	1.76	0.88	No	No	No	No	2	6
267	7x47	7x48	Shared	1.71	1.71	No	No	No	No	7	6
268	2x38	4x38	Shared	1.7	1.7	Yes	No	No	No	7	7
269	5x48	5x52	Shared	1.62	1.62	No	No	No	No	5	3
270	2x41	4x43	Shared	1.59	3.17	No	No	No	No	6	1
271	1x38	1x42	Shared	1.54	2.305	No	No	No	No	6	7
272	E2.H182	E2.P183	Shared	1.53	1.53	No	Yes	No	No	1	2
273	6x49	6x53	Shared	1.49	2.98	No	No	No	No	6	7
274	7x29	7x33	Shared	1.47	2.95	No	No	No	No	2	4
275	1x30	1x33	Shared	1.45	2.175	No	No	No	No	3	3
276	1x47	2x55	Shared	1.43	4.28	No	No	No	No	6	5
277	I2x51	I2x52	Shared	1.39	8.32	No	No	No	No	5	5
278	E2.H185	E2.T192	Shared	1.37	2.74	No	No	No	No	2	4
279	1x33	1x37	bb2_on	0	4.005	No	No	No	No	3	6
280	1x35	1x36	bb2_on	0	3.39	No	No	No	No	6	6
281	1x35	1x39	bb2_on	0	6.045	No	No	Yes	Yes	6	7
282	1x39	7x38	bb2_on	0	3.09	Yes	Yes	No	Yes	7	5
283	1x39	7x39	bb2_on	0	11.72	Yes	Yes	No	No	7	5
284	1x43	2x57	bb2_on	0	3.25	Yes	No	No	No	7	7
285	1x49	7x51	bb2_on	0	4.52	No	No	No	No	8	5
286	1x52	8x58	bb2_on	0	7.37	No	No	No	No	7	7
287	1x53	2x47	bb2_on	0	4.73	No	No	No	No	9	9
288	1x53	7x50	bb2_on	0	3.28	No	No	No	No	9	9
289	1x56	8x50	bb2_on	0	3.77	No	No	Yes	No	7	9
290	1x59	8x57	bb2_on	0	13.465	No	No	No	No	5	5
291	2x38	2x39	bb2_on	0	3.53	Yes	No	No	No	7	8
292	2x42	3x49	bb2_on	0	5.975	Yes	Yes	No	No	7	8
293	2x43	3x46	bb2_on	0	3.565	No	No	No	No	8	9
294	2x46	2x50	bb2_on	0	7.465	No	Yes	Yes	Yes	9	9
295	2x46	3x39	bb2_on	0	3	No	Yes	Yes	No	9	9
296	2x46	7x49	bb2_on	0	6.87	No	Yes	No	Yes	9	9
297	2x52	3x35	bb2_on	0	6.01	No	No	No	No	7	8
298	2x53	2x56	bb2_on	0	4.76	No	Yes	No	Yes	7	7
299	2x56	7x42	bb2_on	0	4.89	No	Yes	Yes	Yes	7	7
300	2x56	Lig	bb2_on	0	5.545	No	Yes	Yes	Yes	7	0
301	2x57	7x42	bb2_on	0	4.16	No	No	Yes	Yes	7	7
302	2x59	E1x52	bb2_on	0	6.555	No	Yes	No	Yes	6	7
303	2x59	3x28	bb2_on	0	4.61	No	Yes	No	Yes	6	5
304	2x59	3x32	bb2_on	0	4.3	No	Yes	No	Yes	6	6
305	2x60	2x63	bb2_on	0	4.17	No	Yes	No	No	6	5
306	2x60	2x64	bb2_on	0	9.195	No	Yes	Yes	Yes	6	4
307	2x60	7x38	bb2_on	0	4.76	No	Yes	No	Yes	6	5
308	2x60	Lig	bb2_on	0	4.71	No	Yes	Yes	Yes	6	0
309	2x63	Lig	bb2_on	0	15.3	No	No	Yes	Yes	5	0
310	2x64	7x31	bb2_on	0	5.675	Yes	Yes	No	Yes	4	4
311	2x64	7x34	bb2_on	0	3.18	Yes	Yes	No	No	4	4
312	2x64	7x35	bb2_on	0	4.23	Yes	Yes	No	No	4	4
313	2x64	Lig	bb2_on	0	14.95	Yes	Yes	Yes	Yes	4	0
314	E1.D104	E1x49	bb2_on	0	3.57	No	No	No	No	4	4
315	E1.D104	E2.F193	bb2_on	0	4.18	No	No	No	Yes	4	1
316	E1.D104	Lig	bb2_on	0	4.715	No	No	Yes	Yes	4	0
317	E1x50	Lig	bb2_on	0	5.965	Yes	Yes	Yes	Yes	8	0
318	3x28	E1x52	bb2_on	0	6.28	No	Yes	No	Yes	5	7
319	3x22	3x26	bb2_on	0	3.715	No	No	No	No	4	7
320	3x28	3x29	bb2_on	0	3.39	No	Yes	No	Yes	5	5
321	3x30	4x62	bb2_on	0	3.465	Yes	Yes	No	No	6	5
322	3x33	5x46	bb2_on	0	8.53	No	No	No	Yes	4	6
323	3x33	Lig	bb2_on	0	5.04	No	No	Yes	Yes	4	0
324	3x34	4x57	bb2_on	0	3.36	No	No	No	No	5	7
325	3x36	3x37	bb2_on	0	3.68	No	No	No	Yes	7	6
326	3x36	5x46	bb2_on	0	4.585	No	No	No	Yes	7	6
327	3x36	Lig	bb2_on	0	5.51	No	No	Yes	Yes	7	0
328	3x37	5x46	bb2_on	0	3.765	No	Yes	No	Yes	6	6
329	3x38	4x53	bb2_on	0	4.85	No	No	No	No	7	8
330	3x43	7x49	bb2_on	0	9.61	No	No	No	Yes	9	9
331	3x44	5x53	bb2_on	0	4.56	No	No	No	No	7	7
332	3x46	3x50	bb2_on	0	3.64	No	No	Yes	Yes	9	9
333	3x50	5x58	bb2_on	0	8.23	Yes	Yes	Yes	Yes	9	8
334	3x50	7x53	bb2_on	0	3.64	Yes	Yes	No	No	9	9
335	I2x56	I2x57	bb2_on	0	3.485	No	No	No	No	5	7
336	4x61	4x65	bb2_on	0	4.31	Yes	Yes	No	No	5	5
337	4x61	E2x52	bb2_on	0	7.075	Yes	Yes	No	No	5	4
338	4x63	4x64	bb2_on	0	3.93	No	No	No	No	4	5
339	4x65	Lig	bb2_on	0	4.88	No	No	Yes	Yes	5	0
340	5x28	E2.H182	bb2_on	0	6.1	No	No	No	Yes	5	1
341	E2.H182	E3.Y291	bb2_on	0	3.27	No	Yes	Yes	Yes	1	1
342	5x29	E2.F184	bb2_on	0	9.615	No	No	No	Yes	3	2
343	E2.F184	E3.Y291	bb2_on	0	7.735	No	Yes	Yes	Yes	2	1
344	E2.F184	E3.V294	bb2_on	0	3.93	No	Yes	No	No	2	5
345	E2.F184	Lig	bb2_on	0	15.73	No	Yes	Yes	Yes	2	0
346	E2.E186	E3.T296	bb2_on	0	4.94	Yes	Yes	No	No	3	3
347	E2.E186	Lig	bb2_on	0	11.345	Yes	Yes	Yes	Yes	3	0
348	E2.F193	Lig	bb2_on	0	10.385	No	Yes	Yes	Yes	1	0
349	E2.S195	Lig	bb2_on	0	12.725	No	No	Yes	Yes	4	0
350	E2x50	Lig	bb2_on	0	4.45	No	No	Yes	Yes	9	0
351	5x34	E2.Y199	bb2_on	0	7.62	No	Yes	Yes	Yes	1	5
352	5x35	E2.Y199	bb2_on	0	12.52	No	No	Yes	Yes	3	5
353	6x59	E2.Y199	bb2_on	0	5.725	No	No	Yes	Yes	4	5
354	5x28	5x30	bb2_on	0	3.56	No	No	No	No	5	3
355	5x29	E3.Y291	bb2_on	0	22.325	No	No	Yes	Yes	3	1
356	5x31	5x34	bb2_on	0	6.38	No	No	No	Yes	2	1
357	5x34	5x35	bb2_on	0	4.58	No	Yes	No	No	1	3
358	5x39	6x55	bb2_on	0	5.09	No	No	Yes	Yes	5	5
359	5x40	6x60	bb2_on	0	3.59	No	No	No	No	4	5
360	5x43	5x44	bb2_on	0	3.045	No	Yes	No	No	6	4
361	5x51	5x55	bb2_on	0	3.75	No	No	No	No	6	5
362	5x51	6x44	bb2_on	0	6.7	No	No	No	No	6	9
363	5x51	6x45	bb2_on	0	3.15	No	No	No	No	6	6
364	5x55	6x41	bb2_on	0	3.23	No	No	No	No	5	7
365	5x58	6x41	bb2_on	0	3.79	Yes	Yes	No	No	8	7
366	5x61	6x37	bb2_on	0	3.07	No	Yes	No	No	8	8
367	5x62	6x38	bb2_on	0	4.73	No	No	No	No	6	5
368	5x65	6x33	bb2_on	0	4.15	No	No	No	No	8	8
369	5x66	5x70	bb2_on	0	3.63	No	No	No	Yes	4	0
370	5x66	6x34	bb2_on	0	3.25	No	No	No	No	4	6
371	5x68	6x30	bb2_on	0	3.95	No	No	No	No	6	7
372	5x70	6x31	bb2_on	0	7.765	No	Yes	No	No	0	5
373	5x72	5x73	bb2_on	0	4.93	No	No	No	No	0	0
374	5x72	6x23	bb2_on	0	4.47	No	No	No	Yes	0	0
375	5x72	6x30	bb2_on	0	4.855	No	No	No	No	0	7
376	6x23	I3.V246	bb2_on	0	4.81	No	Yes	No	No	0	0
377	6x22	I3.G248	bb2_on	0	3.18	No	No	No	No	0	0
378	6x22	I3.I250	bb2_on	0	10.61	No	No	No	No	0	0
379	6x23	6x27	bb2_on	0	3.07	No	Yes	No	No	0	4
380	6x25	6x26	bb2_on	0	5.42	No	No	No	No	4	3
381	6x27	6x31	bb2_on	0	4.36	No	No	No	No	4	5
382	6x32	7x56	bb2_on	0	4.86	No	No	No	No	8	7
383	6x39	6x43	bb2_on	0	2.98	No	No	No	No	6	7
384	6x40	7x52	bb2_on	0	4.16	No	No	No	No	7	8
385	6x43	7x48	bb2_on	0	4.47	No	No	No	No	7	6
386	6x44	7x45	bb2_on	0	6.04	No	No	Yes	Yes	9	9
387	6x48	6x52	bb2_on	0	4.23	Yes	Yes	No	Yes	8	7
388	6x48	7x45	bb2_on	0	9.04	Yes	Yes	Yes	Yes	8	9
389	6x50	7x37	bb2_on	0	3.74	No	No	No	No	9	6
390	6x50	7x40	bb2_on	0	4.93	No	No	No	No	9	8
391	6x51	7x38	bb2_on	0	9.04	Yes	No	No	Yes	5	5
392	6x54	7x38	bb2_on	0	5.635	No	No	No	Yes	5	5
393	6x56	6x60	bb2_on	0	3.52	No	No	No	No	5	5
394	6x57	E3.D295	bb2_on	0	5.175	No	No	No	No	4	1
395	6x57	7x30	bb2_on	0	3.27	No	No	No	Yes	4	4
396	6x58	7x30	bb2_on	0	7.9	No	No	No	Yes	4	4
397	6x58	7x38	bb2_on	0	6.93	No	No	No	Yes	4	5
398	E3.V294	Lig	bb2_on	0	8.52	No	No	Yes	Yes	5	0
399	E3.T296	Lig	bb2_on	0	5.625	No	No	Yes	Yes	3	0
400	7x30	Lig	bb2_on	0	3.705	No	Yes	Yes	Yes	4	0
401	7x31	Lig	bb2_on	0	15.535	No	Yes	Yes	Yes	4	0
402	7x42	Lig	bb2_on	0	3.09	Yes	Yes	Yes	Yes	7	0
403	7x49	7x50	bb2_on	0	3.26	No	Yes	No	No	9	9
404	Lig	Lig	bb2_on	0	37.66	Yes	Yes	Yes	Yes	0	0
405	1x29	1x33	bb2_on	0	5.565	No	No	No	No	0	3
406	1x36	2x65	bb2_on	0	4.105	No	No	No	No	6	4
407	2x53	Lig	bb2_on	0	3.535	No	Yes	Yes	Yes	7	0
408	E2.F184	E2.F193	bb2_on	0	3.215	No	Yes	No	Yes	2	1
409	E2.E186	E2.F193	bb2_on	0	4.665	Yes	Yes	No	Yes	3	1
410	E2.E187	E3.E293	bb2_on	0	6.975	No	No	No	No	4	5
411	E2.Q191	Lig	bb2_on	0	4.09	No	No	Yes	Yes	2	0
412	5x70	5x71	bb2_on	0	4.07	No	Yes	No	No	0	0
413	7x45	7x48	bb2_on	0	2.96	Yes	Yes	No	No	9	6
414	3x54	5x61	bb2_on	0	2.94	No	No	No	Yes	8	8
415	6x23	6x26	bb2_on	0	2.87	No	Yes	No	No	0	3
416	5x67	5x70	bb2_on	0	2.82	No	No	No	Yes	4	0
417	2x42	4x42	bb2_on	0	2.77	Yes	Yes	No	No	7	7
418	5x69	6x30	bb2_on	0	2.77	No	No	No	No	3	7
419	5x64	5x67	bb2_on	0	2.64	No	No	No	No	5	4
420	2x45	4x46	bb2_on	0	2.565	No	No	No	No	9	7
421	3x34	4x50	bb2_on	0	2.43	No	No	Yes	No	5	9
422	6x32	7x55	bb2_on	0	2.43	No	No	No	No	8	6
423	1x57	2x40	bb2_on	0	2.42	No	No	No	No	7	8
424	4x39	4x43	bb2_on	0	2.38	No	No	No	No	2	1
425	2x41	4x42	bb2_on	0	2.365	No	No	No	No	6	7
426	1x38	7x39	bb2_on	0	2.235	No	No	No	No	6	5
427	2x51	2x55	bb2_on	0	2.14	No	No	No	No	8	5
428	3x50	6x40	bb2_on	0	2.14	Yes	Yes	No	No	9	7
429	4x40	4x44	bb2_on	0	2.12	No	No	No	No	3	3
430	1x32	2x65	bb2_on	0	2.075	No	No	No	No	4	4
431	2x49	3x38	bb2_on	0	1.84	No	No	No	No	8	7
432	I3.G248	I3.V246	bb2_on	0	1.84	No	No	No	No	0	0
433	5x62	6x34	bb2_on	0	1.79	No	No	No	No	6	6
434	1x46	2x54	bb2_on	0	1.71	No	No	No	No	8	6
435	3x24	3x27	bb2_on	0	1.71	No	No	No	No	6	5
436	7x32	7x36	bb2_on	0	1.71	No	No	No	No	1	4
437	1x58	1x59	bb2_on	0	1.69	No	No	No	No	3	5
438	2x551	2x56	bb2_on	0	1.69	No	No	No	Yes	5	7
439	E2.I194	E2.P183	bb2_on	0	1.69	No	No	No	No	4	2
440	7x43	7x47	bb2_on	0	1.69	No	No	No	No	5	7
441	I3.E247	I3.G248	bb2_on	0	1.64	No	No	No	No	0	0
442	2x59	2x62	bb2_on	0	1.62	No	Yes	No	No	6	4
443	4x41	I2x55	bb2_on	0	1.61	No	No	No	No	4	5
444	1x34	1x38	bb2_on	0	1.6	No	No	No	No	5	6
445	1x41	1x45	bb2_on	0	1.54	No	No	No	No	4	6
446	7x28	7x32	bb2_on	0	1.52	No	No	No	No	3	1
447	3x24	E1x52	bb2_on	0	1.51	No	No	No	Yes	6	7
448	1x51	1x55	bb2_on	0	1.455	No	No	No	No	4	4
449	3x56	I2x50	bb2_on	0	1.44	No	No	No	No	6	8
450	4x55	4x59	bb2_on	0	1.43	No	No	No	No	4	4
451	5x31	5x33	bb2_on	0	1.37	No	No	No	No	2	1
452	3x55	3x56	bb2_on	0	1.31	No	No	No	No	7	6
453	1x31	7x31	bb2_on	0	1.26	No	No	No	Yes	4	4
454	3x52	3x56	bb2_on	0	1.24	No	No	No	No	4	6
455	7x28	7x31	bb2_on	0	1.24	No	No	No	Yes	3	4
456	8x52	8x56	bb2_on	0	0.75	No	No	No	No	4	4
457	E2.E186	E2.E187	bb2_on	0	0.635	Yes	Yes	No	No	3	4
458	5x60	5x63	bb2_on	0	0.62	No	Yes	No	No	3	3

Orange: nodes, hubs and links specific of bb2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of bb2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	bb2_off Avg Int. Strength	bb2_on Avg Int. Strength	bb2_off Num Of Links	bb2_on Num Of Links	ConSurf
1	1x43	bb2_off	5.462	3.21	5	3	7
2	1x50	bb2_off	6.7425	5.81	4	2	9
3	1x60	bb2_off	3.815	4.82333	4	3	6
4	2x38	bb2_off	4.492	3.20333	5	3	7
5	3x39	bb2_off	8.22	4.445	4	2	9
6	3x41	bb2_off	5.13	4.88333	4	3	5
7	3x42	bb2_off	5.155	4.675	4	2	8
8	4x50	bb2_off	7.63	8.48833	4	3	9
9	E2.L181	bb2_off	4.9175	3.17	4	1	4
10	5x38	bb2_off	5.39	6.42	4	3	6
11	5x47	bb2_off	7.226	6.51667	5	3	8
12	6x51	bb2_off	4.6225	7.55833	4	3	5
13	7x46	bb2_off	5.975	7.44	4	3	8
14	8x50	bb2_off	7.98	3.56667	4	3	9
15	1x39	Shared	10.1575	6.032	4	5	7
16	2x42	Shared	5.17167	4.185	6	5	7
17	2x50	Shared	8.0375	7.425	4	5	9
18	2x64	Shared	6.025	6.70917	4	6	4
19	E1x50	Shared	5.95143	8.60917	7	6	8
20	3x30	Shared	4.51	4.28375	4	4	6
21	3x50	Shared	6.8475	4.4125	4	4	9
22	3x51	Shared	8.59	8.1975	4	4	8
23	4x61	Shared	8.8725	5.369	4	5	5
24	E2.E186	Shared	7.8125	6.9025	4	6	3
25	E2.Y199	Shared	8.6625	11.132	4	5	5
26	5x58	Shared	7.794	7.187	5	5	8
27	6x48	Shared	7.634	7.5825	5	4	8
28	6x55	Shared	11.34	5.163	4	5	5
29	E3.Y291	Shared	9.5575	9.955	4	5	1
30	7x42	Shared	7.37	4.0675	4	4	7
31	7x45	Shared	6.7	7.235	4	4	9
32	7x54	Shared	7.1875	7.0425	4	4	7
33	8x54	Shared	8.9025	8.04875	4	4	7
34	Lig	Shared	10.6869	9.93766	13	32	0
35	2x46	bb2_on	5.76	5.441	2	5	9
36	2x53	bb2_on	5.255	3.94875	2	4	7
37	2x56	bb2_on	4.58	5.513	1	5	7
38	2x59	bb2_on	2.92	4.27125	1	4	6
39	2x60	bb2_on	7.78	5.602	2	5	6
40	E1x52	bb2_on	7.77333	7.34375	3	4	7
41	3x28	bb2_on	4.34	4.6	2	4	5
42	3x29	bb2_on	7.53333	7.00625	3	4	5
43	3x32	bb2_on	6.36	5.91	3	4	6
44	3x37	bb2_on	4.865	3.54125	2	4	6
45	E2.H182	bb2_on	2.81333	4.212	3	5	1
46	E2.F184	bb2_on	2.485	7.47417	2	6	2
47	E2.F193	bb2_on	9.755	5.61125	2	4	1
48	5x34	bb2_on	2.26	7.75625	1	4	1
49	5x43	bb2_on	7.19667	6.04625	3	4	6
50	5x46	bb2_on	4.39333	5.146	3	5	6
51	5x60	bb2_on	5.34333	3.29625	3	4	3
52	5x61	bb2_on	6.19	3.224	3	5	8
53	5x70	bb2_on	0	4.57125	0	4	0
54	6x23	bb2_on	0	3.805	0	4	0
55	6x52	bb2_on	6.95	6.09375	3	4	7
56	7x30	bb2_on	6.63333	4.999	3	5	4
57	7x31	bb2_on	10.05	6.25	1	5	4
58	7x38	bb2_on	10.15	6.86667	1	6	5
59	7x49	bb2_on	5.72667	7.474	3	5	9

Orange: nodes, hubs and links specific of bb2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of bb2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	bb2_off Recurrence	bb2_on Recurrence	bb2_off Hub1?	bb2_on Hub1?	bb2_off Hub2?	bb2_on Hub2?	ConSurf1	ConSurf2
1	1x42	7x42	bb2_off	11.2003	0	No	No	Yes	Yes	7	7
2	1x39	1x43	bb2_off	28.4023	0	Yes	Yes	Yes	No	7	7
3	1x43	2x54	bb2_off	45.0944	0	Yes	No	No	No	7	6
4	1x50	2x50	bb2_off	22.219	6.56257	Yes	No	Yes	Yes	9	9
5	1x50	2x47	bb2_off	12.8648	0	Yes	No	No	No	9	9
6	2x50	7x49	bb2_off	27.4118	6.94043	Yes	Yes	No	Yes	9	9
7	6x40	7x49	bb2_off	45.1119	0	No	No	No	Yes	7	9
8	6x40	7x53	bb2_off	34.3629	0	No	No	No	No	7	9
9	7x53	8x50	bb2_off	32.1416	0	No	No	Yes	No	9	9
10	1x54	2x47	bb2_off	11.4817	1.82818	No	No	No	No	7	9
11	3x39	7x46	bb2_off	39.9601	0	Yes	No	Yes	No	9	8
12	3x39	6x44	bb2_off	100	0	Yes	No	No	No	9	9
13	3x40	6x44	bb2_off	88.1901	0	No	No	No	No	8	9
14	3x40	3x41	bb2_off	86.3088	4.92887	No	No	Yes	No	8	5
15	3x41	4x49	bb2_off	79.2756	1.65037	Yes	No	No	No	5	7
16	3x42	4x49	bb2_off	78.5078	0	Yes	No	No	No	8	7
17	2x42	3x42	bb2_off	71.9435	0	Yes	Yes	Yes	No	7	8
18	2x38	2x42	bb2_off	28.6895	0	Yes	No	Yes	Yes	7	7
19	2x39	3x49	bb2_off	17.1141	0	No	No	No	No	8	8
20	2x40	I1x50	bb2_off	13.1931	7.07935	No	No	No	No	8	7
21	1x60	I1x50	bb2_off	11.7278	5.27895	Yes	No	No	No	6	7
22	3x49	3x50	bb2_off	10.1043	0	No	No	Yes	Yes	8	9
23	3x46	6x37	bb2_off	38.9989	0	No	No	No	No	9	8
24	3x50	6x37	bb2_off	12.0326	0	Yes	Yes	No	No	9	8
25	3x32	Lig	bb2_off	10.7432	5.97355	No	Yes	Yes	Yes	6	0
26	1x39	2x57	bb2_off	26.3099	0	Yes	Yes	No	No	7	7
27	2x57	2x58	bb2_off	25.0908	1.78373	No	No	No	No	7	9
28	2x58	E1x52	bb2_off	23.8483	0	No	No	No	Yes	9	7
29	E1x50	E1x52	bb2_off	21.4981	6.71816	Yes	Yes	No	Yes	8	7
30	E1x50	E2.L181	bb2_off	12.4956	0	Yes	Yes	Yes	No	8	4
31	4x61	Lig	bb2_off	14.6759	2.93399	Yes	Yes	Yes	Yes	5	0
32	3x33	4x61	bb2_off	13.8143	0	No	No	Yes	Yes	4	5
33	3x33	4x57	bb2_off	12.3139	0	No	No	No	No	4	7
34	3x30	4x57	bb2_off	10.7959	9.53545	Yes	Yes	No	No	6	7
35	3x39	7x45	bb2_off	27.3004	0	Yes	No	Yes	Yes	9	9
36	3x41	5x46	bb2_off	10.7021	0	Yes	No	No	Yes	5	6
37	5x58	6x37	bb2_off	35.2538	1.56146	Yes	Yes	No	No	8	8
38	3x50	3x53	bb2_off	11.0011	0	Yes	Yes	No	No	9	8
39	E2.Y199	Lig	bb2_off	22.3245	0	Yes	Yes	Yes	Yes	5	0
40	6x58	E2.Y199	bb2_off	11.6223	0	No	No	Yes	Yes	4	5
41	E2.Y199	E3.Y291	bb2_off	10.4267	1.47255	Yes	Yes	Yes	Yes	5	1
42	5x35	Lig	bb2_off	11.1241	0	No	No	Yes	Yes	3	0
43	E3.S292	E3.Y291	bb2_off	14.588	0	No	No	Yes	Yes	1	1
44	6x54	6x58	bb2_off	10.3153	0.111136	No	No	No	No	5	4
45	1x43	7x42	bb2_off	12.5366	0	Yes	No	Yes	Yes	7	7
46	2x50	3x39	bb2_off	36.4494	2.53945	Yes	Yes	Yes	No	9	9
47	2x54	7x46	Shared	46.1024	14.6144	No	No	Yes	No	6	8
48	8x50	8x54	Shared	18.7962	16.5481	Yes	No	Yes	Yes	9	7
49	2x38	3x49	Shared	24.2234	20.9046	Yes	No	No	No	7	8
50	2x37	2x39	Shared	16.4166	15.9146	No	No	No	No	8	8
51	2x37	2x40	Shared	14.8107	14.1698	No	No	No	No	8	8
52	2x42	3x46	Shared	40.0422	34.2132	Yes	Yes	No	No	7	9
53	6x44	6x48	Shared	85.6816	71.7215	No	No	Yes	Yes	9	8
54	6x48	Lig	Shared	81.3973	100	Yes	Yes	Yes	Yes	8	0
55	5x58	5x61	Shared	25.8	58.7242	Yes	Yes	No	Yes	8	8
56	3x51	5x61	Shared	17.0789	53.6897	Yes	Yes	No	Yes	8	8
57	6x55	Lig	Shared	11.8392	13.4808	Yes	Yes	Yes	Yes	5	0
58	6x52	Lig	Shared	19.2474	12.3972	No	Yes	Yes	Yes	7	0
59	5x47	6x52	Shared	10.456	13.3307	Yes	No	No	Yes	8	7
60	7x54	8x54	Shared	11.8333	21.866	Yes	Yes	Yes	Yes	7	7
61	7x45	7x49	Shared	21.0468	38.2641	Yes	Yes	No	Yes	9	9
62	1x39	7x39	bb2_on	0	18.9764	Yes	Yes	No	No	7	5
63	2x57	7x42	bb2_on	0	12.2861	No	No	Yes	Yes	7	7
64	2x53	Lig	bb2_on	0	19.4321	No	Yes	Yes	Yes	7	0
65	2x53	7x46	bb2_on	2.86602	20.0433	No	Yes	Yes	No	7	8
66	1x46	2x54	bb2_on	0	12.2583	No	No	No	No	8	6
67	1x45	1x46	bb2_on	2.86602	15.0311	No	No	No	No	6	8
68	1x45	7x51	bb2_on	1.43594	10.0633	No	No	No	No	6	5
69	2x50	7x46	bb2_on	9.09038	16.8371	Yes	Yes	Yes	No	9	8
70	6x48	7x45	bb2_on	0	37.1694	Yes	Yes	Yes	Yes	8	9
71	7x49	7x50	bb2_on	0	37.4972	No	Yes	No	No	9	9
72	5x51	6x44	bb2_on	0	79.9733	No	No	No	No	6	9
73	5x51	5x55	bb2_on	0	78.6619	No	No	No	No	6	5
74	5x55	6x41	bb2_on	0	78.0118	No	No	No	No	5	7
75	5x58	6x41	bb2_on	0	74.2221	Yes	Yes	No	No	8	7
76	3x50	5x58	bb2_on	0	42.7262	Yes	Yes	Yes	Yes	9	8
77	3x50	6x40	bb2_on	0	38.6753	Yes	Yes	No	No	9	7
78	6x36	6x40	bb2_on	9.25448	35.3745	No	No	No	No	8	7
79	6x36	7x56	bb2_on	6.88665	33.6964	No	No	No	No	8	7
80	6x32	7x56	bb2_on	0	32.1905	No	No	No	No	8	7
81	6x32	7x55	bb2_on	0	30.5012	No	No	No	No	8	6
82	7x54	7x55	bb2_on	2.38542	28.8008	Yes	Yes	No	No	7	6
83	1x53	7x50	bb2_on	0	42.3372	No	No	No	No	9	9
84	1x53	2x43	bb2_on	2.3737	40.0367	No	No	No	No	9	8
85	1x56	8x50	bb2_on	0	11.1303	No	No	Yes	No	7	9
86	2x43	3x46	bb2_on	0	39.2643	No	No	No	No	8	9
87	2x42	3x49	bb2_on	0	22.6161	Yes	Yes	No	No	7	8
88	2x38	2x39	bb2_on	0	17.6484	Yes	No	No	No	7	8
89	3x36	Lig	bb2_on	0	47.116	No	No	Yes	Yes	7	0
90	3x36	3x37	bb2_on	0	38.5697	No	No	No	Yes	7	6
91	3x37	4x53	bb2_on	1.55902	31.0013	No	Yes	No	No	6	8
92	3x38	4x53	bb2_on	0	29.5566	No	No	No	No	7	8
93	3x38	4x50	bb2_on	1.55902	26.6337	No	No	Yes	No	7	9
94	E1x50	Lig	bb2_on	0	12.5417	Yes	Yes	Yes	Yes	8	0
95	E2.F184	Lig	bb2_on	0	19.6377	No	Yes	Yes	Yes	2	0
96	E2.F184	E3.Y291	bb2_on	0	17.6595	No	Yes	Yes	Yes	2	1
97	E2.H182	E3.Y291	bb2_on	0	15.4423	No	Yes	Yes	Yes	1	1
98	3x34	4x50	bb2_on	0	23.6664	No	No	Yes	No	5	9
99	3x34	4x54	bb2_on	0	11.0858	No	No	No	No	5	4
100	3x34	4x57	bb2_on	0	11.0858	No	No	No	No	5	7
101	3x30	4x59	bb2_on	6.17161	12.7528	Yes	Yes	No	No	6	4
102	3x51	3x55	bb2_on	4.79428	43.5764	Yes	Yes	No	No	8	7
103	3x55	5x64	bb2_on	3.20595	37.5361	No	No	No	No	7	5
104	E2x52	Lig	bb2_on	2.63744	13.3696	No	No	Yes	Yes	4	0
105	E2.Y199	E2x52	bb2_on	0.18169	12.5361	Yes	Yes	No	No	5	4
106	5x34	E2.Y199	bb2_on	0	10.0967	No	Yes	Yes	Yes	1	5
107	5x47	6x49	bb2_on	4.65362	11.8582	Yes	No	No	No	8	6
108	5x64	5x67	bb2_on	0	36.0024	No	No	No	No	5	4
109	5x67	5x70	bb2_on	0	34.4577	No	No	No	Yes	4	0
110	5x70	6x31	bb2_on	0	25.1222	No	Yes	No	No	0	5
111	6x27	6x31	bb2_on	0	23.6886	No	No	No	No	4	5
112	6x23	6x27	bb2_on	0	22.2327	No	Yes	No	No	0	4
113	7x45	7x48	bb2_on	0	14.4143	Yes	Yes	No	No	9	6
114	7x30	Lig	bb2_on	0	10.4801	No	Yes	Yes	Yes	4	0
115	1x38	7x39	bb2_on	0	14.2476	No	No	No	No	6	5
116	7x38	Lig	bb2_on	1.50627	14.3365	No	Yes	Yes	Yes	5	0
117	7x42	Lig	bb2_on	0	19.371	Yes	Yes	Yes	Yes	7	0
118	3x46	3x50	bb2_on	0	21.0602	No	No	Yes	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x35	2x64	Shared	9.67	3.025	0	0	2	1
1x36	2x64	bb2_off	9.74	0	0	0	2	1
1x39	1x43	bb2_off	10.88	0	3	1	2	2
1x39	2x60	Shared	12.64	5.175	3	1	2	1
1x39	7x42	Shared	14.44	4.13	3	1	2	1
1x42	7x42	bb2_off	6.28	0	0	0	2	1
1x43	7x42	bb2_off	7.54	0	3	0	2	1
2x53	3x35	Shared	6.01	3	0	1	1	2
2x53	7x46	Shared	4.5	4.5	0	1	1	2
2x551	3x28	bb2_off	4.56	0	0	0	2	2
2x56	3x32	Shared	4.58	10.68	0	1	1	1
2x63	E1x50	Shared	6	5	0	1	1	1
E1.D104	E2.E186	bb2_off	10.39	0	0	1	1	1
E1x49	E2.F193	bb2_off	4.28	0	0	0	2	1
E1x50	E1x52	Shared	15.03	15.03	2	1	1	2
3x25	E1x50	Shared	3.92	5.22	2	1	2	1
E1x50	E2.L181	bb2_off	4.56	0	2	1	1	2
E1x50	E2x50	Shared	6.53	17.63	2	1	1	1
3x25	E2.L181	Shared	4.76	3.17	2	1	2	2
3x25	E2x50	Shared	7.28	7.28	2	1	2	1
3x28	3x32	Shared	4.12	4.12	0	1	2	1
3x29	4x61	Shared	6.29	3.145	1	1	1	1
3x29	4x65	Shared	5.34	6.235	1	1	1	1
3x29	Lig	Shared	10.97	15.255	1	1	1	0
3x32	Lig	Shared	10.38	4.54	0	1	1	0
3x33	4x57	bb2_off	4.73	0	0	1	1	2
3x33	4x61	bb2_off	9.28	0	0	1	1	1
3x36	6x48	bb2_off	4.9	0	0	1	1	1
4x61	5x38	Shared	3.69	7.39	1	1	1	1
4x61	Lig	Shared	16.23	4.925	1	1	1	0
4x65	E2x52	bb2_off	5.34	0	0	1	1	1
E2.E186	E2.S188	Shared	10.06	4.31	0	1	1	2
E2.E186	E2.T189	Shared	8.47	15.52	0	1	1	2
E2.Q191	E2.T189	bb2_off	5.67	0	0	0	1	2
E2.F193	E2.Q191	bb2_off	15.23	0	0	1	1	1
E2.Y199	E2x52	Shared	5.56	13.91	1	1	1	1
E2x52	Lig	Shared	15.54	17.935	1	1	1	0
6x58	E2.Y199	bb2_off	4.12	0	0	1	2	1
E2.Y199	E3.Y291	Shared	11.91	15.885	1	1	1	2
E2.Y199	Lig	bb2_off	13.06	0	1	1	1	0
5x35	E3.Y291	bb2_off	6.95	0	0	1	1	2
5x35	Lig	bb2_off	8.23	0	0	1	1	0
5x38	5x42	Shared	4.18	6.97	1	1	1	2
5x38	6x55	Shared	6.53	4.9	1	1	1	1
5x38	Lig	bb2_off	7.16	0	1	1	1	0
5x39	6x59	Shared	6.52	6.52	0	1	2	2
5x42	6x55	Shared	7.63	3.18	1	1	2	1
5x43	5x47	Shared	8.25	8.25	1	1	2	2
5x43	6x52	Shared	6.79	9.615	1	1	2	1
5x47	6x52	Shared	7.62	5.44	1	1	2	1
6x44	6x48	Shared	14.03	13.03	0	1	2	1
6x48	6x51	bb2_off	4.52	0	1	1	1	1
6x48	7x41	bb2_off	6.48	0	1	1	1	2
6x48	Lig	Shared	8.24	4.03	1	1	1	0
6x51	7x37	bb2_off	4.69	0	1	1	1	2
6x51	7x41	Shared	4.69	5.47	1	1	1	2
6x51	Lig	Shared	4.59	8.165	1	1	1	0
6x52	Lig	Shared	6.44	5.09	1	1	1	0
6x54	7x33	Shared	4.56	3.04	0	1	2	2
6x55	6x59	Shared	5.09	6.995	1	1	1	2
6x55	Lig	Shared	26.11	5.65	1	1	1	0
7x30	E3.D295	Shared	8.82	3.15	0	1	1	2
7x30	7x33	bb2_off	4.11	0	0	1	1	2
7x30	7x34	Shared	6.97	6.97	0	1	1	2
7x31	7x35	Shared	10.05	7.54	0	1	1	2
7x38	Lig	Shared	10.15	11.745	0	1	1	0
1x32	2x64	bb2_off	3.52	0	0	0	2	1
2x59	2x60	bb2_off	2.92	0	0	1	2	1
3x21	E1x50	Shared	2.81	2.81	0	0	2	1
3x24	E1x50	bb2_off	2.81	0	0	0	2	1
1x39	2x57	bb2_off	2.67	0	3	1	2	2
E2.F184	E2.S195	Shared	2.64	4.62	0	1	1	1
6x54	6x58	Shared	2.51	6.26	0	1	2	2
E2.E186	E2.F184	bb2_off	2.33	0	0	1	1	1
5x28	Lig	bb2_off	1.83	0	0	0	1	0
5x28	5x31	bb2_off	1.63	0	0	0	1	2
E3.T296	E3.V294	bb2_off	1.59	0	0	1	1	1
5x30	5x31	bb2_off	1.49	0	0	0	2	2
1x31	1x32	bb2_off	1.43	0	0	0	2	2
7x39	7x42	bb2_off	1.22	0	0	0	2	1
2x64	2x65	bb2_off	1.17	0	0	1	1	2
1x35	1x36	bb2_on	0	3.39	0	0	2	2
1x35	1x39	bb2_on	0	6.045	0	0	2	2
1x39	7x38	bb2_on	0	3.09	3	1	2	1
1x39	7x39	bb2_on	0	11.72	3	1	2	2
1x43	2x57	bb2_on	0	3.25	3	0	2	2
2x53	2x56	bb2_on	0	4.76	0	1	1	1
2x56	7x42	bb2_on	0	4.89	0	1	1	1
2x56	Lig	bb2_on	0	5.545	0	1	1	0
2x57	7x42	bb2_on	0	4.16	0	0	2	1
2x59	E1x52	bb2_on	0	6.555	0	1	2	2
2x59	3x28	bb2_on	0	4.61	0	1	2	2
2x59	3x32	bb2_on	0	4.3	0	1	2	1
2x60	2x63	bb2_on	0	4.17	0	1	1	1
2x60	2x64	bb2_on	0	9.195	0	1	1	1
2x60	7x38	bb2_on	0	4.76	0	1	1	1
2x60	Lig	bb2_on	0	4.71	0	1	1	0
2x63	Lig	bb2_on	0	15.3	0	1	1	0
2x64	7x31	bb2_on	0	5.675	0	1	1	1
2x64	7x34	bb2_on	0	3.18	0	1	1	2
2x64	7x35	bb2_on	0	4.23	0	1	1	2
2x64	Lig	bb2_on	0	14.95	0	1	1	0
E1.D104	E1x49	bb2_on	0	3.57	0	1	1	2
E1.D104	E2.F193	bb2_on	0	4.18	0	1	1	1
E1.D104	Lig	bb2_on	0	4.715	0	1	1	0
E1x50	Lig	bb2_on	0	5.965	2	1	1	0
3x28	E1x52	bb2_on	0	6.28	0	1	2	2
3x28	3x29	bb2_on	0	3.39	0	1	2	1
3x33	5x46	bb2_on	0	8.53	0	1	1	2
3x33	Lig	bb2_on	0	5.04	0	1	1	0
3x36	3x37	bb2_on	0	3.68	0	1	1	2
3x36	5x46	bb2_on	0	4.585	0	1	1	2
3x36	Lig	bb2_on	0	5.51	0	1	1	0
3x37	5x46	bb2_on	0	3.765	0	1	2	2
4x61	4x65	bb2_on	0	4.31	1	1	1	1
4x61	E2x52	bb2_on	0	7.075	1	1	1	1
4x65	Lig	bb2_on	0	4.88	0	1	1	0
5x28	E2.H182	bb2_on	0	6.1	0	0	1	2
E2.H182	E3.Y291	bb2_on	0	3.27	0	0	2	2
5x29	E2.F184	bb2_on	0	9.615	0	1	2	1
E2.F184	E3.Y291	bb2_on	0	7.735	0	1	1	2
E2.F184	E3.V294	bb2_on	0	3.93	0	1	1	1
E2.F184	Lig	bb2_on	0	15.73	0	1	1	0
E2.E186	E3.T296	bb2_on	0	4.94	0	1	1	1
E2.E186	Lig	bb2_on	0	11.345	0	1	1	0
E2.F193	Lig	bb2_on	0	10.385	0	1	1	0
E2.S195	Lig	bb2_on	0	12.725	0	1	1	0
E2x50	Lig	bb2_on	0	4.45	2	1	1	0
5x34	E2.Y199	bb2_on	0	7.62	0	1	2	1
5x35	E2.Y199	bb2_on	0	12.52	0	1	1	1
6x59	E2.Y199	bb2_on	0	5.725	0	1	2	1
5x28	5x30	bb2_on	0	3.56	0	0	1	2
5x29	E3.Y291	bb2_on	0	22.325	0	1	2	2
5x31	5x34	bb2_on	0	6.38	0	0	2	2
5x34	5x35	bb2_on	0	4.58	0	1	2	1
5x39	6x55	bb2_on	0	5.09	0	1	2	1
6x44	7x45	bb2_on	0	6.04	0	1	2	2
6x48	6x52	bb2_on	0	4.23	1	1	1	1
6x48	7x45	bb2_on	0	9.04	1	1	1	2
6x51	7x38	bb2_on	0	9.04	1	1	1	1
6x54	7x38	bb2_on	0	5.635	0	1	2	1
6x57	E3.D295	bb2_on	0	5.175	0	1	2	2
6x57	7x30	bb2_on	0	3.27	0	1	2	1
6x58	7x30	bb2_on	0	7.9	0	1	2	1
6x58	7x38	bb2_on	0	6.93	0	1	2	1
E3.V294	Lig	bb2_on	0	8.52	0	1	1	0
E3.T296	Lig	bb2_on	0	5.625	0	1	1	0
7x30	Lig	bb2_on	0	3.705	0	1	1	0
7x31	Lig	bb2_on	0	15.535	0	1	1	0
7x42	Lig	bb2_on	0	3.09	3	1	1	0
1x36	2x65	bb2_on	0	4.105	0	0	2	2
2x53	Lig	bb2_on	0	3.535	0	1	1	0
E2.F184	E2.F193	bb2_on	0	3.215	0	1	1	1
E2.E186	E2.F193	bb2_on	0	4.665	0	1	1	1
E2.Q191	Lig	bb2_on	0	4.09	0	0	1	0
1x32	2x65	bb2_on	0	2.075	0	0	2	2
2x551	2x56	bb2_on	0	1.69	0	0	2	1
3x24	E1x52	bb2_on	0	1.51	0	0	2	2
1x31	7x31	bb2_on	0	1.26	0	0	2	1
7x28	7x31	bb2_on	0	1.24	0	0	2	1
E2.E186	E2.E187	bb2_on	0	0.635	0	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	bb2_off	7W41-BB₂-PD176252
	bb2_on	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2

Network Difference
Value	bb2_off	bb2_on
I_min	3.63	2.98
Number of Linked Nodes	270	288
Number of Specific Nodes	9 (3.33%)	27 (9.38%)
Number of Shared Nodes	261 (96.67%)	261 (90.63%)
Number of Links	278	341
Number of Specific Links	117 (42.09%)	180 (52.79%)
Number of Shared Links	161 (57.91%)	161 (47.21%)
Number of Hubs	34	45
Number of Specific Hubs	14 (41.18%)	25 (55.56%)
Number of Shared Hubs	20 (58.82%)	20 (44.44%)
Average % Shared Neighbours (Jaccard)	39.17
Average % Shared Neighbours (Otsuka)	48.23
Average % Shared Neighbours (Overlap Coefficient)	57.62
Average % Shared Cliques (k3-6)	51.89
Graphlets Similarity	0.562848

Paths Difference
Value	bb2_off	bb2_on
Number Of Nodes in MetaPath	60	74
Specific Nodes in MetaPath	26 (43.33%)	40 (54.05%)
Shared Nodes in MetaPath	261 (96.67%)	261 (96.67%)
Number Of Links MetaPath	61	72
Specific Links in MetaPath	46 (75.41%)	57 (79.17%)
Shared Links in MetaPath	161 (57.91%)	161 (57.91%)
Number of Shortest Paths	33345	47479
Length Of Smallest Path	3	3
Average Path Length	13.0645	11.9917
Length of Longest Path	31	31
Minimum Path Strength	1.405	1.0725
Average Path Strength	6.86461	5.69729
Maximum Path Strength	21.17	19.105
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.927095	0.934107
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.7619	4.16667
Average % Of Corr. Nodes	54.426	60.8322
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	42.526	41.6287
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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