psnGPCR

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Orange: nodes, hubs and links specific of beta1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	beta1_off Int. Strength	beta1_on Int. Strength	beta1_off Hub1?	beta1_on Hub1?	beta1_off Hub2?	beta1_on Hub2?	ConSurf1	ConSurf2
1	1x31	1x35	beta1_off	100	0	No	No	No	No	3	4
2	1x32	2x65	beta1_off	100	0	No	No	No	No	5	5
3	1x51	2x51	beta1_off	100	0	No	No	No	No	3	7
4	1x53	7x53	beta1_off	100	0	No	No	Yes	Yes	9	9
5	1x60	I1x49	beta1_off	100	0	Yes	No	No	No	6	5
6	8x49	I1x50	beta1_off	100	0	No	No	Yes	No	6	8
7	2x38	I2x53	beta1_off	100	0	No	No	Yes	Yes	6	7
8	2x39	3x50	beta1_off	100	0	No	No	Yes	No	8	9
9	2x42	3x46	beta1_off	100	0	Yes	Yes	No	No	8	9
10	2x43	7x53	beta1_off	100	0	No	No	Yes	Yes	7	9
11	2x53	2x56	beta1_off	100	0	No	No	Yes	No	8	7
12	2x53	7x46	beta1_off	100	0	No	No	No	No	8	9
13	2x62	E1x52	beta1_off	100	0	No	No	Yes	Yes	4	5
14	2x63	E1x50	beta1_off	100	0	No	No	Yes	Yes	5	7
15	3x26	E2.W182	beta1_off	100	0	Yes	No	Yes	Yes	6	5
16	3x26	E2.R183	beta1_off	100	0	Yes	No	Yes	No	6	4
17	3x30	4x62	beta1_off	100	0	No	No	No	No	6	4
18	3x33	4x57	beta1_off	100	0	No	No	No	No	6	7
19	3x33	4x61	beta1_off	100	0	No	No	Yes	No	6	6
20	3x34	4x50	beta1_off	100	0	No	No	Yes	No	5	9
21	3x37	4x57	beta1_off	100	0	Yes	Yes	No	No	6	7
22	3x38	4x53	beta1_off	100	0	No	No	No	No	7	8
23	3x39	6x44	beta1_off	100	0	No	No	Yes	Yes	9	9
24	3x40	5x51	beta1_off	100	0	No	No	No	No	8	6
25	3x41	4x53	beta1_off	100	0	Yes	No	No	No	6	8
26	3x42	4x49	beta1_off	100	0	No	No	No	No	8	6
27	3x43	6x44	beta1_off	100	0	No	No	Yes	Yes	8	9
28	3x44	5x54	beta1_off	100	0	No	No	No	No	6	8
29	3x47	6x41	beta1_off	100	0	No	No	Yes	No	8	8
30	3x48	5x57	beta1_off	100	0	No	No	No	No	6	6
31	3x49	3x50	beta1_off	100	0	Yes	Yes	Yes	No	9	9
32	3x50	3x53	beta1_off	100	0	Yes	No	No	No	9	8
33	3x50	I2x53	beta1_off	100	0	Yes	No	Yes	Yes	9	7
34	3x50	6x34	beta1_off	100	0	Yes	No	No	No	9	7
35	3x51	5x61	beta1_off	100	0	No	Yes	No	No	8	9
36	3x54	5x68	beta1_off	100	0	No	No	No	No	9	7
37	4x58	4x62	beta1_off	100	0	No	Yes	No	No	5	4
38	4x61	E2x52	beta1_off	100	0	Yes	No	Yes	Yes	6	4
39	E2.W182	E2.Y193	beta1_off	100	0	Yes	Yes	Yes	No	5	3
40	E2.W182	E2x52	beta1_off	100	0	Yes	Yes	Yes	Yes	5	4
41	E2.D186	E2.Q188	beta1_off	100	0	No	No	No	No	1	2
42	E2.C192	E2x51	beta1_off	100	0	No	No	No	No	4	5
43	5x39	E2x52	beta1_off	100	0	Yes	Yes	Yes	Yes	7	4
44	5x39	E2.T203	beta1_off	100	0	Yes	Yes	No	No	7	4
45	5x37	6x59	beta1_off	100	0	No	No	Yes	No	5	5
46	5x37	E3.R317	beta1_off	100	0	No	No	No	No	5	1
47	5x39	Lig	beta1_off	100	0	Yes	Yes	Yes	Yes	7	0
48	5x41	6x59	beta1_off	100	0	No	No	Yes	No	5	5
49	5x44	5x48	beta1_off	100	0	No	No	Yes	No	6	5
50	5x48	6x52	beta1_off	100	0	Yes	No	Yes	Yes	5	7
51	5x51	6x45	beta1_off	100	0	No	No	No	No	6	5
52	5x56	5x60	beta1_off	100	0	No	No	No	Yes	5	5
53	6x29	6x32	beta1_off	100	0	No	No	No	No	6	8
54	6x35	7x55	beta1_off	100	0	No	No	Yes	No	7	7
55	6x36	7x55	beta1_off	100	0	No	No	Yes	No	8	7
56	6x40	7x49	beta1_off	100	0	No	No	Yes	Yes	8	9
57	6x40	7x52	beta1_off	100	0	No	No	No	No	8	8
58	6x40	7x53	beta1_off	100	0	No	No	Yes	Yes	8	9
59	6x44	6x48	beta1_off	100	0	Yes	Yes	Yes	Yes	9	8
60	6x44	7x45	beta1_off	100	0	Yes	Yes	No	No	9	9
61	6x47	7x40	beta1_off	100	0	No	No	No	No	8	7
62	6x47	7x48	beta1_off	100	0	No	No	No	No	8	6
63	6x48	Lig	beta1_off	100	0	Yes	Yes	Yes	Yes	8	0
64	6x55	Lig	beta1_off	100	0	No	Yes	Yes	Yes	6	0
65	7x30	7x33	beta1_off	100	0	No	No	Yes	No	5	4
66	7x39	7x42	beta1_off	100	0	Yes	Yes	Yes	Yes	6	7
67	7x49	7x50	beta1_off	100	0	Yes	Yes	Yes	No	9	9
68	7x53	8x50	beta1_off	100	0	Yes	Yes	Yes	Yes	9	8
69	8x48	8x51	beta1_off	100	0	No	No	No	No	6	8
70	8x51	8x55	beta1_off	100	0	No	No	No	No	8	4
71	3x50	6x30	beta1_off	100	0	Yes	No	No	No	9	7
72	6x26	I2x54	beta1_off	100	0	No	No	No	No	0	5
73	5x68	6x27	beta1_off	100	0	No	No	No	No	7	0
74	2x42	4x45	beta1_off	50	0	Yes	Yes	No	No	8	6
75	5x72	6x24	beta1_off	50	0	No	No	No	No	0	0
76	5x68	6x31	beta1_off	50	0	No	No	No	No	7	5
77	2x56	3x28	beta1_off	50	0	Yes	No	Yes	Yes	7	6
78	3x23	3x24	beta1_off	50	0	No	No	No	No	2	4
79	3x54	3x55	beta1_off	0	0	No	No	No	No	9	7
80	1x47	2x51	beta1_off	50	0	No	No	No	No	6	7
81	5x65	6x31	beta1_off	50	0	No	No	No	No	8	5
82	3x46	6x41	beta1_off	0	0	No	No	Yes	No	9	8
83	E2.V202	E2x51	beta1_off	50	0	No	No	No	No	4	5
84	1x35	1x39	beta1_off	0	0	No	No	No	No	4	6
85	3x46	6x37	beta1_off	50	0	No	No	No	No	9	8
86	3x48	3x52	beta1_off	0	0	No	No	No	No	6	5
87	7x54	8x54	beta1_off	0	0	No	No	No	No	6	7
88	I2x51	I2x52	beta1_off	50	0	No	No	No	No	6	5
89	E2.E185	E2.L190	beta1_off	50	0	No	No	No	No	2	1
90	5x56	5x57	beta1_off	0	0	No	No	No	No	5	6
91	6x25	6x29	beta1_off	50	0	No	No	No	No	0	6
92	3x47	5x57	beta1_off	50	0	No	No	No	No	8	6
93	E2.V202	E2.Y193	beta1_off	0	0	No	No	Yes	No	4	3
94	8x48	8x52	beta1_off	50	0	No	No	No	No	6	4
95	6x24	6x28	beta1_off	50	0	No	No	No	No	0	0
96	6x27	I2x50	beta1_off	50	0	No	No	No	No	0	8
97	7x35	7x39	beta1_off	0	0	No	No	Yes	Yes	4	6
98	3x23	3x27	beta1_off	50	0	No	No	No	No	2	4
99	8x58	CT.F359	beta1_off	50	0	No	No	No	No	6	0
100	E2.L190	E2.Y193	beta1_off	0	0	No	No	Yes	No	1	3
101	1x35	2x65	beta1_off	0	0	No	No	No	No	4	5
102	1x52	8x57	beta1_off	0	0	No	No	No	No	6	6
103	I2x51	I2x55	beta1_off	50	0	No	No	No	No	6	5
104	8x55	8x60	beta1_off	50	0	No	No	No	No	4	7
105	5x66	5x70	beta1_off	50	0	No	No	No	No	5	0
106	4x41	I2x56	beta1_off	0	0	No	No	No	No	7	5
107	6x37	6x38	beta1_off	0	0	No	No	No	No	8	5
108	2x44	2x48	beta1_off	0	0	No	No	No	No	5	5
109	4x56	5x461	beta1_off	0	0	No	No	No	No	5	6
110	7x43	7x48	beta1_off	0	0	No	No	No	No	4	6
111	6x57	E3.V320	beta1_off	50	0	No	No	No	Yes	5	5
112	1x44	1x48	beta1_off	0	0	No	No	No	No	5	4
113	1x56	I1x50	beta1_off	0	0	No	No	Yes	No	7	8
114	8x53	I1x50	beta1_off	0	0	No	No	Yes	No	7	8
115	7x33	7x36	beta1_off	0	0	Yes	No	No	No	4	5
116	1x30	1x33	beta1_off	0	0	No	No	No	No	2	5
117	2x52	2x551	beta1_off	0	0	No	No	No	No	6	4
118	2x52	3x31	beta1_off	0	0	No	No	No	No	6	5
119	6x57	E3.L319	beta1_off	0	0	No	No	No	No	5	6
120	5x69	5x72	beta1_off	0	0	No	No	No	No	5	0
121	1x32	1x36	beta1_off	0	0	No	No	No	No	5	5
122	6x26	6x27	beta1_off	0	0	No	No	No	No	0	0
123	1x38	1x41	beta1_off	0	0	No	No	No	No	5	4
124	1x57	I1x51	beta1_off	0	0	No	Yes	No	No	7	7
125	4x60	E2.W181	beta1_off	0	0	No	No	No	No	7	6
126	5x67	5x71	beta1_off	0	0	No	No	No	No	4	0
127	1x42	1x43	beta1_off	0	0	No	No	No	No	6	5
128	1x42	2x57	beta1_off	0	0	No	No	Yes	No	6	7
129	1x59	1x60	beta1_off	0	0	No	No	Yes	No	5	6
130	6x25	I3.K274	beta1_off	0	0	No	No	No	No	0	0
131	I2x55	I2x56	beta1_off	0	0	No	No	No	No	5	5
132	2x41	4x43	beta1_off	0	0	No	No	No	No	5	4
133	6x24	I3.A272	beta1_off	0	0	No	No	No	No	0	0
134	6x32	7x55	beta1_off	0	0	No	No	Yes	No	8	7
135	1x39	2x61	Shared	100	0	No	No	No	No	6	6
136	1x39	7x39	Shared	100	100	No	No	Yes	Yes	6	6
137	1x43	2x57	Shared	100	0	No	No	Yes	No	5	7
138	1x46	2x54	Shared	100	100	No	Yes	No	No	7	7
139	1x46	7x46	Shared	100	100	No	Yes	No	No	7	9
140	1x46	7x47	Shared	100	0	No	Yes	No	No	7	6
141	1x47	2x55	Shared	100	0	No	No	No	No	6	5
142	1x49	7x50	Shared	100	100	No	No	Yes	No	8	9
143	1x50	2x50	Shared	100	100	No	No	No	Yes	9	9
144	1x50	7x50	Shared	100	100	No	No	Yes	No	9	9
145	1x52	8x54	Shared	100	50	No	No	No	No	6	7
146	1x53	2x47	Shared	100	0	No	No	No	No	9	8
147	1x53	7x50	Shared	100	100	No	No	Yes	No	9	9
148	1x54	2x47	Shared	100	0	No	No	No	No	7	8
149	1x57	2x40	Shared	100	100	No	Yes	No	Yes	7	9
150	1x57	2x44	Shared	100	100	No	Yes	No	No	7	5
151	1x60	I1x50	Shared	100	100	Yes	No	Yes	No	6	8
152	I1x48	I1x51	Shared	100	100	No	No	No	No	6	7
153	8x49	I1x49	Shared	100	100	No	No	No	No	6	5
154	8x50	I1x50	Shared	100	100	Yes	Yes	Yes	No	8	8
155	2x37	2x40	Shared	100	100	No	No	No	Yes	7	9
156	2x39	3x49	Shared	100	100	No	No	Yes	Yes	8	9
157	2x40	8x50	Shared	100	100	No	Yes	Yes	Yes	9	8
158	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	5
159	2x42	3x49	Shared	100	100	Yes	Yes	Yes	Yes	8	9
160	2x42	4x42	Shared	100	0	Yes	Yes	No	No	8	7
161	2x42	4x46	Shared	100	100	Yes	Yes	No	No	8	7
162	2x45	3x42	Shared	100	100	No	No	No	No	9	8
163	2x45	4x46	Shared	100	100	No	No	No	No	9	7
164	2x45	4x50	Shared	100	100	No	No	Yes	No	9	9
165	2x46	3x42	Shared	100	100	No	Yes	No	No	9	8
166	2x46	3x43	Shared	100	100	No	Yes	No	No	9	8
167	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
168	2x50	7x49	Shared	100	100	No	Yes	Yes	Yes	9	9
169	2x52	3x35	Shared	100	0	No	No	No	No	6	6
170	2x53	3x35	Shared	100	0	No	No	No	No	8	6
171	2x551	3x31	Shared	100	100	No	No	No	No	4	5
172	2x56	3x32	Shared	100	100	Yes	No	No	Yes	7	7
173	2x56	7x42	Shared	100	100	Yes	No	Yes	Yes	7	7
174	2x57	2x58	Shared	100	100	Yes	No	No	No	7	9
175	2x57	7x39	Shared	100	0	Yes	No	Yes	Yes	7	6
176	2x59	E1x50	Shared	100	100	No	Yes	Yes	Yes	4	7
177	2x59	E1x52	Shared	100	100	No	Yes	Yes	Yes	4	5
178	2x59	3x28	Shared	100	100	No	Yes	Yes	Yes	4	6
179	2x60	3x28	Shared	100	50	No	No	Yes	Yes	6	6
180	2x64	7x39	Shared	100	100	No	No	Yes	Yes	5	6
181	2x66	E1x51	Shared	100	100	No	No	No	No	4	4
182	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	7	5
183	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	7
184	3x28	E1x50	Shared	100	100	Yes	Yes	Yes	Yes	6	7
185	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	7	9
186	E1x51	E1x52	Shared	100	100	No	No	Yes	Yes	4	5
187	3x22	E2.P196	Shared	100	0	No	No	No	No	4	3
188	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
189	3x26	4x62	Shared	100	100	Yes	No	No	No	6	4
190	3x26	4x64	Shared	100	100	Yes	No	No	No	6	5
191	3x29	E2x52	Shared	100	50	No	No	Yes	Yes	6	4
192	3x30	4x58	Shared	100	100	No	No	No	Yes	6	5
193	3x30	4x61	Shared	100	100	No	No	Yes	No	6	6
194	3x32	7x42	Shared	100	100	No	Yes	Yes	Yes	7	7
195	3x32	Lig	Shared	100	100	No	Yes	Yes	Yes	7	0
196	3x33	Lig	Shared	100	100	No	No	Yes	Yes	6	0
197	3x36	6x48	Shared	100	100	No	No	Yes	Yes	6	8
198	3x36	Lig	Shared	100	100	No	No	Yes	Yes	6	0
199	3x37	3x41	Shared	100	100	Yes	Yes	Yes	No	6	6
200	3x37	4x53	Shared	100	100	Yes	Yes	No	No	6	8
201	3x37	5x461	Shared	100	100	Yes	Yes	No	No	6	6
202	3x38	4x50	Shared	100	100	No	No	Yes	No	7	9
203	3x40	5x50	Shared	100	0	No	No	No	No	8	9
204	3x40	6x44	Shared	100	100	No	No	Yes	Yes	8	9
205	3x41	4x49	Shared	100	100	Yes	No	No	No	6	6
206	3x41	4x52	Shared	100	100	Yes	No	No	No	6	4
207	3x44	5x53	Shared	100	100	No	No	No	No	6	6
208	3x49	I2x53	Shared	100	100	Yes	Yes	Yes	Yes	9	7
209	3x51	3x55	Shared	100	100	No	Yes	No	No	8	7
210	3x53	I2x53	Shared	100	100	No	No	Yes	Yes	8	7
211	3x55	3x56	Shared	100	0	No	No	No	No	7	6
212	I2x53	I2x57	Shared	100	100	Yes	Yes	No	No	7	6
213	4x38	4x41	Shared	100	100	No	No	No	No	8	7
214	4x56	5x46	Shared	100	100	No	No	No	No	5	4
215	4x61	E2.W182	Shared	100	100	Yes	No	Yes	Yes	6	5
216	4x63	E2.W181	Shared	100	100	No	No	No	No	5	6
217	4x64	E2.R183	Shared	100	100	No	No	Yes	No	5	4
218	E2.R183	E2.W182	Shared	100	100	Yes	No	Yes	Yes	4	5
219	E2.T203	E2.W182	Shared	100	100	No	No	Yes	Yes	4	5
220	5x39	E2.W182	Shared	100	100	Yes	Yes	Yes	Yes	7	5
221	E2.R183	E2.Y193	Shared	100	100	Yes	No	Yes	No	4	3
222	E2.D184	E2.D186	Shared	100	100	No	No	No	No	4	1
223	5x36	E2.D184	Shared	100	100	No	No	No	No	5	4
224	E2.D186	E2.P187	Shared	100	50	No	No	No	No	1	1
225	E2.A189	E2.Y193	Shared	100	100	No	No	Yes	No	4	3
226	E2.C192	E2.C198	Shared	100	100	No	No	No	No	4	5
227	E2.D195	E2.P196	Shared	100	100	No	No	No	No	3	3
228	E2.D195	E2.G197	Shared	100	0	No	No	No	No	3	4
229	E2.C198	E2.D195	Shared	100	100	No	No	No	No	5	3
230	E2.C198	E2x51	Shared	100	100	No	No	No	No	5	5
231	E2.T203	E2x52	Shared	100	100	No	No	Yes	Yes	4	4
232	E2x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	4	0
233	5x36	5x39	Shared	100	0	No	No	Yes	Yes	5	7
234	5x39	5x43	Shared	100	100	Yes	Yes	No	No	7	6
235	5x43	Lig	Shared	100	100	No	No	Yes	Yes	6	0
236	5x461	Lig	Shared	100	100	No	No	Yes	Yes	6	0
237	5x47	5x48	Shared	100	100	No	Yes	Yes	No	7	5
238	5x47	6x52	Shared	100	100	No	Yes	Yes	Yes	7	7
239	5x48	6x56	Shared	100	100	Yes	No	No	No	5	5
240	5x49	5x50	Shared	100	0	No	No	No	No	5	9
241	5x51	5x55	Shared	100	100	No	No	No	No	6	5
242	5x54	6x41	Shared	100	100	No	No	Yes	No	8	8
243	5x62	5x66	Shared	100	100	No	No	No	No	6	5
244	5x64	5x67	Shared	100	0	No	No	No	No	6	4
245	6x35	6x39	Shared	100	50	No	No	No	No	7	7
246	6x39	7x52	Shared	100	0	No	No	No	No	7	8
247	6x39	7x55	Shared	100	0	No	No	Yes	No	7	7
248	6x43	7x48	Shared	100	50	No	No	No	No	6	6
249	6x47	7x45	Shared	100	100	No	No	No	No	8	9
250	6x48	6x51	Shared	100	100	Yes	Yes	Yes	Yes	8	7
251	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
252	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	6
253	6x49	6x53	Shared	100	100	No	No	No	No	7	6
254	6x50	7x37	Shared	100	100	No	No	No	No	9	5
255	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	7	7
256	6x51	7x34	Shared	100	100	Yes	Yes	Yes	Yes	7	4
257	6x51	7x38	Shared	100	100	Yes	Yes	No	No	7	6
258	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
259	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
260	6x54	E3.V320	Shared	100	100	No	No	No	Yes	4	5
261	6x54	7x34	Shared	100	100	No	No	Yes	Yes	4	4
262	6x55	7x34	Shared	100	100	No	Yes	Yes	Yes	6	4
263	6x59	6x60	Shared	100	50	Yes	No	No	No	5	5
264	6x61	E3.L319	Shared	100	100	No	No	No	No	4	6
265	7x30	E3.V320	Shared	100	100	No	No	No	Yes	5	5
266	7x30	7x32	Shared	100	100	No	No	No	No	5	3
267	7x32	7x33	Shared	100	100	No	No	Yes	No	3	4
268	7x33	7x37	Shared	100	100	Yes	No	No	No	4	5
269	7x38	7x42	Shared	100	100	No	No	Yes	Yes	6	7
270	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
271	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
272	7x49	7x53	Shared	100	100	Yes	Yes	Yes	Yes	9	9
273	8x47	8x48	Shared	100	100	No	No	No	No	8	6
274	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	8
275	8x50	8x54	Shared	100	100	Yes	Yes	No	No	8	7
276	5x47	6x49	Shared	50	100	No	Yes	No	No	7	7
277	4x48	4x52	Shared	0	0	No	No	No	No	3	4
278	6x58	7x34	Shared	50	100	No	No	Yes	Yes	4	4
279	5x41	5x45	Shared	0	0	No	No	No	No	5	4
280	5x45	5x49	Shared	0	0	No	No	No	No	4	5
281	3x24	E1x52	Shared	50	0	No	No	Yes	Yes	4	5
282	3x21	E1x50	Shared	0	0	No	No	Yes	Yes	7	7
283	1x52	8x58	Shared	50	50	No	No	No	No	6	6
284	3x54	5x64	Shared	50	0	No	No	No	No	9	6
285	5x60	5x63	Shared	50	50	No	Yes	No	No	5	4
286	2x49	4x50	Shared	0	0	No	No	Yes	No	8	9
287	1x45	7x47	Shared	0	50	No	No	No	No	5	6
288	5x36	5x38	Shared	50	0	No	No	No	No	5	4
289	E1x49	E1x51	Shared	0	0	No	No	No	No	3	4
290	5x55	5x59	Shared	0	0	No	No	No	No	5	2
291	4x60	5x39	Shared	0	100	No	No	Yes	Yes	7	7
292	1x50	2x51	Shared	0	0	No	No	No	No	9	7
293	3x51	5x60	Shared	0	100	No	Yes	No	Yes	8	5
294	3x56	I2x52	Shared	0	50	No	No	No	No	6	5
295	1x48	1x49	Shared	0	0	No	No	No	No	4	8
296	2x38	4x39	Shared	0	0	No	No	No	No	6	3
297	2x41	4x39	Shared	50	100	No	No	No	No	5	3
298	2x67	E1x49	Shared	0	0	No	No	No	No	4	3
299	1x56	8x53	Shared	0	0	No	No	No	No	7	7
300	E3.D318	E3.R317	Shared	0	0	No	No	No	No	2	1
301	6x41	6x42	Shared	0	0	Yes	No	No	No	8	5
302	5x40	6x59	Shared	0	100	No	No	Yes	No	6	5
303	4x38	4x40	Shared	0	0	No	No	No	No	8	5
304	1x58	I1x51	Shared	0	0	No	No	No	No	2	7
305	4x59	4x60	Shared	0	100	No	No	No	No	6	7
306	5x58	6x41	Shared	0	100	No	Yes	Yes	No	9	8
307	4x44	4x48	Shared	0	0	No	No	No	No	3	3
308	3x34	4x54	Shared	0	0	No	No	No	No	5	3
309	4x55	4x59	Shared	0	50	No	No	No	No	4	6
310	1x34	1x37	Shared	0	0	No	No	No	No	4	4
311	1x55	8x57	Shared	0	0	No	No	No	No	4	6
312	1x60	8x56	Shared	0	100	Yes	No	No	No	6	4
313	5x70	5x71	Shared	0	50	No	No	No	No	0	0
314	1x53	7x54	beta1_on	0	100	No	No	No	No	9	6
315	1x57	8x50	beta1_on	0	100	No	Yes	Yes	Yes	7	8
316	1x59	8x56	beta1_on	0	100	No	No	No	No	5	4
317	2x40	I1x50	beta1_on	0	100	No	Yes	Yes	No	9	8
318	2x38	I2x57	beta1_on	0	100	No	No	No	No	6	6
319	2x40	2x43	beta1_on	0	100	No	Yes	No	No	9	7
320	2x46	2x50	beta1_on	0	100	No	Yes	No	Yes	9	9
321	2x46	7x49	beta1_on	0	100	No	Yes	Yes	Yes	9	9
322	2x50	3x39	beta1_on	0	100	No	Yes	No	No	9	9
323	2x51	2x55	beta1_on	0	100	No	No	No	No	7	5
324	2x53	2x54	beta1_on	0	100	No	No	No	No	8	7
325	3x27	4x58	beta1_on	0	100	No	No	No	Yes	4	5
326	3x27	4x62	beta1_on	0	100	No	No	No	No	4	4
327	3x28	Lig	beta1_on	0	100	Yes	Yes	Yes	Yes	6	0
328	3x31	4x58	beta1_on	0	100	No	No	No	Yes	5	5
329	3x32	3x36	beta1_on	0	100	No	Yes	No	No	7	6
330	3x34	4x57	beta1_on	0	100	No	No	No	No	5	7
331	3x34	4x58	beta1_on	0	100	No	No	No	Yes	5	5
332	3x40	6x48	beta1_on	0	100	No	No	Yes	Yes	8	8
333	3x43	7x49	beta1_on	0	100	No	No	Yes	Yes	8	9
334	3x43	7x53	beta1_on	0	100	No	No	Yes	Yes	8	9
335	3x46	3x50	beta1_on	0	100	No	No	Yes	No	9	9
336	3x47	5x58	beta1_on	0	100	No	No	No	Yes	8	9
337	3x49	I2x57	beta1_on	0	100	Yes	Yes	No	No	9	6
338	3x50	5x58	beta1_on	0	100	Yes	No	No	Yes	9	9
339	3x50	7x53	beta1_on	0	100	Yes	No	Yes	Yes	9	9
340	3x51	5x56	beta1_on	0	100	No	Yes	No	No	8	5
341	3x51	5x57	beta1_on	0	100	No	Yes	No	No	8	6
342	3x54	5x61	beta1_on	0	100	No	No	No	No	9	9
343	3x55	5x60	beta1_on	0	100	No	No	No	Yes	7	5
344	I2x52	I2x56	beta1_on	0	100	No	No	No	No	5	5
345	4x57	4x58	beta1_on	0	100	No	No	No	Yes	7	5
346	4x59	E2.W181	beta1_on	0	100	No	No	No	No	6	6
347	4x61	5x39	beta1_on	0	100	Yes	No	Yes	Yes	6	7
348	6x55	E2x52	beta1_on	0	100	No	Yes	Yes	Yes	6	4
349	E2.V202	E3.R317	beta1_on	0	100	No	No	No	No	4	1
350	5x37	6x60	beta1_on	0	100	No	No	No	No	5	5
351	5x44	6x52	beta1_on	0	100	No	No	Yes	Yes	6	7
352	5x44	6x55	beta1_on	0	100	No	No	No	Yes	6	6
353	5x44	6x56	beta1_on	0	100	No	No	No	No	6	5
354	5x47	5x51	beta1_on	0	100	No	Yes	No	No	7	6
355	5x47	6x44	beta1_on	0	100	No	Yes	Yes	Yes	7	9
356	5x51	6x44	beta1_on	0	100	No	No	Yes	Yes	6	9
357	5x54	6x44	beta1_on	0	100	No	No	Yes	Yes	8	9
358	5x58	6x37	beta1_on	0	100	No	Yes	No	No	9	8
359	5x58	6x40	beta1_on	0	100	No	Yes	No	No	9	8
360	5x60	5x64	beta1_on	0	100	No	Yes	No	No	5	6
361	5x62	6x34	beta1_on	0	100	No	No	No	No	6	7
362	5x66	6x30	beta1_on	0	100	No	No	No	No	5	7
363	5x67	5x70	beta1_on	0	100	No	No	No	No	4	0
364	5x68	5x71	beta1_on	0	100	No	No	No	No	7	0
365	5x69	6x29	beta1_on	0	100	No	No	No	No	5	6
366	5x69	6x30	beta1_on	0	100	No	No	No	No	5	7
367	5x72	6x29	beta1_on	0	100	No	No	No	No	0	6
368	5x73	I3.R247	beta1_on	0	100	No	No	No	No	0	0
369	6x43	7x52	beta1_on	0	100	No	No	No	No	6	8
370	6x45	6x49	beta1_on	0	100	No	No	No	No	5	7
371	6x48	7x45	beta1_on	0	100	Yes	Yes	No	No	8	9
372	6x58	E3.R317	beta1_on	0	100	No	No	No	No	4	1
373	E3.L319	E3.V320	beta1_on	0	100	No	No	No	Yes	6	5
374	7x33	E3.V320	beta1_on	0	100	Yes	No	No	Yes	4	5
375	7x36	7x37	beta1_on	0	100	No	No	No	No	5	5
376	7x36	7x40	beta1_on	0	100	No	No	No	No	5	7
377	7x45	7x49	beta1_on	0	100	No	No	Yes	Yes	9	9
378	7x52	7x53	beta1_on	0	100	No	No	Yes	Yes	8	9
379	7x54	8x50	beta1_on	0	100	No	No	Yes	Yes	6	8
380	7x55	8x51	beta1_on	0	100	Yes	No	No	No	7	8
381	8x56	8x57	beta1_on	0	100	No	No	No	No	4	6
382	2x63	Lig	beta1_on	0	100	No	No	Yes	Yes	5	0
383	6x51	6x55	beta1_on	0	100	Yes	Yes	No	Yes	7	6
384	7x35	Lig	beta1_on	0	100	No	No	Yes	Yes	4	0
385	7x39	Lig	beta1_on	0	100	Yes	Yes	Yes	Yes	6	0
386	5x62	6x37	beta1_on	0	0	No	No	No	No	6	8
387	1x56	8x54	beta1_on	0	50	No	No	No	No	7	7
388	E2.K191	E2.Q188	beta1_on	0	50	No	No	No	No	3	2
389	3x44	3x48	beta1_on	0	0	No	No	No	No	6	6
390	3x37	4x56	beta1_on	0	0	Yes	Yes	No	No	6	5
391	1x42	1x46	beta1_on	0	0	No	No	No	Yes	6	7
392	3x45	4x45	beta1_on	0	0	No	No	No	No	5	6
393	5x49	5x53	beta1_on	0	0	No	No	No	No	5	6
394	5x40	E2.T203	beta1_on	0	0	No	No	No	No	6	4
395	5x57	5x58	beta1_on	0	0	No	No	No	Yes	6	9
396	1x54	2x48	beta1_on	0	0	No	No	No	No	7	5
397	3x52	I2x53	beta1_on	0	0	No	No	Yes	Yes	5	7
398	8x47	8x49	beta1_on	0	0	No	No	No	No	8	6
399	E2.C192	E2.Y193	beta1_on	0	0	No	No	Yes	No	4	3
400	7x51	7x55	beta1_on	0	0	No	No	Yes	No	6	7
401	5x73	6x29	beta1_on	0	50	No	No	No	No	0	6
402	3x56	I2x50	beta1_on	0	0	No	No	No	No	6	8
403	6x54	6x57	beta1_on	0	0	No	No	No	No	4	5
404	1x47	1x51	beta1_on	0	0	No	No	No	No	6	3
405	1x38	1x42	beta1_on	0	0	No	No	No	No	5	6
406	2x59	2x62	beta1_on	0	0	No	Yes	No	No	4	4
407	E2.D184	E2.E185	beta1_on	0	0	No	No	No	No	4	2
408	6x31	I3.R247	beta1_on	0	0	No	No	No	No	5	0
409	1x57	1x58	beta1_on	0	0	No	Yes	No	No	7	2
410	E2.P187	E2.Q188	beta1_on	0	0	No	No	No	No	1	2
411	1x35	2x64	beta1_on	0	0	No	No	No	No	4	5
412	6x36	6x40	beta1_on	0	0	No	No	No	No	8	8
413	6x32	6x36	beta1_on	0	0	No	No	No	No	8	8
414	E2.L190	E2.Q194	beta1_on	0	0	No	No	No	No	1	3
415	3x23	4x62	beta1_on	0	0	No	No	No	No	2	4
416	I3.F248	I3.R247	beta1_on	0	0	No	No	No	No	0	0

Orange: nodes, hubs and links specific of beta1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	beta1_off Avg Int. Strength	beta1_on Avg Int. Strength	beta1_off Num Of Links	beta1_on Num Of Links	ConSurf
1	1x60	beta1_off	0	0	4	2	6
2	I1x50	beta1_off	0	0	5	3	8
3	2x56	beta1_off	50	0	4	2	7
4	2x57	beta1_off	50	0	4	3	7
5	3x26	beta1_off	50	0	4	2	6
6	3x41	beta1_off	100	0	4	3	6
7	3x50	beta1_off	100	0	6	3	9
8	4x50	beta1_off	0	0	4	3	9
9	4x61	beta1_off	50	0	4	3	6
10	E2.R183	beta1_off	100	0	4	3	4
11	E2.Y193	beta1_off	0	0	5	3	3
12	5x48	beta1_off	50	0	4	2	5
13	6x41	beta1_off	0	0	5	3	8
14	6x59	beta1_off	0	0	4	2	5
15	7x33	beta1_off	50	0	4	3	4
16	7x50	beta1_off	100	0	4	3	9
17	7x55	beta1_off	0	0	4	3	7
18	2x42	Shared	100	50	6	4	8
19	E1x50	Shared	100	100	7	6	7
20	E1x52	Shared	100	0	5	4	5
21	3x28	Shared	50	50	4	4	6
22	3x37	Shared	100	0	4	4	6
23	3x49	Shared	50	100	4	4	9
24	I2x53	Shared	100	0	5	4	7
25	E2.W182	Shared	100	100	7	4	5
26	E2x52	Shared	100	0	6	4	4
27	5x39	Shared	100	100	7	5	7
28	6x44	Shared	100	100	5	4	9
29	6x48	Shared	100	100	6	6	8
30	6x51	Shared	100	100	5	6	7
31	6x52	Shared	100	100	5	5	7
32	7x34	Shared	0	50	4	4	4
33	7x39	Shared	50	0	5	4	6
34	7x42	Shared	100	100	5	4	7
35	7x49	Shared	100	100	4	5	9
36	7x53	Shared	100	50	5	4	9
37	8x50	Shared	100	100	5	6	8
38	Lig	Shared	100	100	13	14	0
39	1x46	beta1_on	0	0	3	4	7
40	1x57	beta1_on	0	0	3	4	7
41	2x40	beta1_on	0	100	3	5	9
42	2x46	beta1_on	0	50	2	4	9
43	2x50	beta1_on	0	100	3	5	9
44	2x59	beta1_on	0	0	3	4	4
45	3x32	beta1_on	0	50	3	4	7
46	3x51	beta1_on	0	50	3	4	8
47	4x58	beta1_on	0	100	2	5	5
48	5x47	beta1_on	0	100	3	5	7
49	5x58	beta1_on	0	100	1	6	9
50	5x60	beta1_on	0	50	3	4	5
51	6x55	beta1_on	0	50	2	4	6
52	E3.V320	beta1_on	50	50	3	4	5

Orange: nodes, hubs and links specific of beta1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	beta1_off Recurrence	beta1_on Recurrence	beta1_off Hub1?	beta1_on Hub1?	beta1_off Hub2?	beta1_on Hub2?	ConSurf1	ConSurf2
1	7x39	7x42	beta1_off	10.9147	0	Yes	Yes	Yes	Yes	6	7
2	2x56	7x42	beta1_off	66.3711	0.590201	Yes	No	Yes	Yes	7	7
3	2x53	2x56	beta1_off	97.7824	0	No	No	Yes	No	8	7
4	2x53	7x46	beta1_off	91.9389	0	No	No	No	No	8	9
5	7x53	8x50	beta1_off	41.8283	0	Yes	Yes	Yes	Yes	9	8
6	2x40	8x50	beta1_off	11.1248	4.31208	No	Yes	Yes	Yes	9	8
7	8x50	I1x50	beta1_off	12.6493	9.12102	Yes	Yes	Yes	No	8	8
8	7x42	Lig	beta1_off	69.2026	1.83986	Yes	Yes	Yes	Yes	7	0
9	3x37	3x41	beta1_off	36.4437	6.89271	Yes	Yes	Yes	No	6	6
10	3x41	4x49	beta1_off	34.4031	1.38818	Yes	No	No	No	6	6
11	3x42	4x49	beta1_off	33.9312	0	No	No	No	No	8	6
12	3x49	I2x53	beta1_off	12.3728	4.76377	Yes	Yes	Yes	Yes	9	7
13	6x48	Lig	beta1_off	45.1464	0	Yes	Yes	Yes	Yes	8	0
14	6x44	6x48	beta1_off	47.9778	0	Yes	Yes	Yes	Yes	9	8
15	3x43	6x44	beta1_off	37.2935	0	No	No	Yes	Yes	8	9
16	2x46	3x43	beta1_off	36.7995	3.0022	No	Yes	No	No	9	8
17	3x37	4x53	beta1_off	36.4161	1.38818	Yes	Yes	No	No	6	8
18	3x38	4x53	beta1_off	35.9018	0	No	No	No	No	7	8
19	3x38	4x50	beta1_off	35.3838	1.68328	No	No	Yes	No	7	9
20	2x45	4x50	beta1_off	33.474	5.03779	No	No	Yes	No	9	9
21	2x42	3x46	beta1_off	70.8708	0	Yes	Yes	No	No	8	9
22	2x56	3x28	beta1_off	35.7746	0	Yes	No	Yes	Yes	7	6
23	2x59	E1x52	beta1_off	12.6051	8.07311	No	Yes	Yes	Yes	4	5
24	E1x50	E1x52	beta1_off	12.6733	8.10925	Yes	Yes	Yes	Yes	7	5
25	E2.W182	E2x52	beta1_off	15.3333	0	Yes	Yes	Yes	Yes	5	4
26	E2.W182	E2.Y193	beta1_off	24.2221	0	Yes	Yes	Yes	No	5	3
27	E2.V202	E2.Y193	beta1_off	16.3637	0	No	No	Yes	No	4	3
28	E2.V202	E2x51	beta1_off	14.4927	0	No	No	No	No	4	5
29	E2.C198	E2x51	beta1_off	10.5147	2.7613	No	No	No	No	5	5
30	5x39	Lig	beta1_off	26.6885	0	Yes	Yes	Yes	Yes	7	0
31	3x40	6x44	beta1_off	11.2244	5.38408	No	No	Yes	Yes	8	9
32	3x46	6x41	beta1_off	65.8752	0	No	No	Yes	No	9	8
33	3x47	6x41	beta1_off	55.4601	0	No	No	Yes	No	8	8
34	3x47	5x57	beta1_off	53.7163	0	No	No	No	No	8	6
35	5x56	5x57	beta1_off	48.7023	0	No	No	No	No	5	6
36	5x56	5x60	beta1_off	46.9418	0	No	No	No	Yes	5	5
37	3x51	5x60	beta1_off	43.4099	8.96143	No	Yes	No	Yes	8	5
38	3x51	3x55	beta1_off	39.8632	4.98058	No	Yes	No	No	8	7
39	3x54	3x55	beta1_off	23.9585	0	No	No	No	No	9	7
40	3x54	5x68	beta1_off	11.6778	0	No	No	No	No	9	7
41	3x55	3x56	beta1_off	14.5111	4.10431	No	No	No	No	7	6
42	3x56	I2x52	beta1_off	12.677	2.06269	No	No	No	No	6	5
43	I2x51	I2x52	beta1_off	10.8391	0	No	No	No	No	6	5
44	3x54	5x64	beta1_off	10.5755	2.05366	No	No	No	No	9	6
45	6x40	7x49	beta1_off	12.8502	0	No	No	Yes	Yes	8	9
46	6x40	7x52	beta1_off	12.0742	0	No	No	No	No	8	8
47	6x39	7x52	beta1_off	10.6732	7.54012	No	No	No	No	7	8
48	2x56	3x32	beta1_off	60.9516	1.02984	Yes	No	No	Yes	7	7
49	3x32	Lig	beta1_off	61.3589	1.05393	No	Yes	Yes	Yes	7	0
50	2x50	7x46	Shared	86.0032	15.1736	No	Yes	No	No	9	9
51	1x50	2x50	Shared	16.2642	52.7508	No	No	No	Yes	9	9
52	1x50	7x50	Shared	10.0243	46.0508	No	No	Yes	No	9	9
53	2x50	7x49	Shared	69.35	65.1179	No	Yes	Yes	Yes	9	9
54	7x49	7x53	Shared	46.6985	25.0775	Yes	Yes	Yes	Yes	9	9
55	5x461	Lig	Shared	69.068	13.5746	No	No	Yes	Yes	6	0
56	3x37	5x461	Shared	67.8735	12.3009	Yes	Yes	No	No	6	6
57	2x45	3x42	Shared	68.6901	28.5585	No	No	No	No	9	8
58	2x45	4x46	Shared	100	22.1868	No	No	No	No	9	7
59	2x42	4x46	Shared	98.3539	20.5788	Yes	Yes	No	No	8	7
60	2x42	3x49	Shared	22.6571	14.0504	Yes	Yes	Yes	Yes	8	9
61	2x46	3x42	Shared	36.3129	30.1364	No	Yes	No	No	9	8
62	2x59	3x28	Shared	13.9895	10.717	No	Yes	Yes	Yes	4	6
63	3x28	E1x50	Shared	19.3334	13.2283	Yes	Yes	Yes	Yes	6	7
64	E1x51	E1x52	Shared	11.2723	10.8133	No	No	Yes	Yes	4	5
65	E2x52	Lig	Shared	19.6302	24.659	Yes	Yes	Yes	Yes	4	0
66	5x39	E2.W182	Shared	15.6632	17.9319	Yes	Yes	Yes	Yes	7	5
67	6x51	7x34	Shared	12.371	15.553	Yes	Yes	Yes	Yes	7	4
68	6x54	7x34	Shared	16.7877	12.876	No	No	Yes	Yes	4	4
69	6x54	E3.V320	Shared	15.2798	10.9609	No	No	No	Yes	4	5
70	7x39	Lig	beta1_on	0	10.2954	Yes	Yes	Yes	Yes	6	0
71	3x36	Lig	beta1_on	0.623064	29.9136	No	No	Yes	Yes	6	0
72	3x36	6x48	beta1_on	0.199086	31.38	No	No	Yes	Yes	6	8
73	6x48	7x45	beta1_on	0	100	Yes	Yes	No	No	8	9
74	7x45	7x49	beta1_on	0	98.3378	No	No	Yes	Yes	9	9
75	1x46	7x46	beta1_on	5.74215	13.683	No	Yes	No	No	7	9
76	6x51	Lig	beta1_on	7.75881	33.7409	Yes	Yes	Yes	Yes	7	0
77	6x48	6x51	beta1_on	2.43143	46.3519	Yes	Yes	Yes	Yes	8	7
78	6x52	Lig	beta1_on	3.94669	45.2498	Yes	Yes	Yes	Yes	7	0
79	6x48	6x52	beta1_on	1.14659	32.4009	Yes	Yes	Yes	Yes	8	7
80	1x53	7x50	beta1_on	8.53119	41.9585	No	No	Yes	No	9	9
81	1x53	7x54	beta1_on	0	36.4088	No	No	No	No	9	6
82	7x54	8x50	beta1_on	0	35.0086	No	No	Yes	Yes	6	8
83	2x46	7x49	beta1_on	0	25.8996	No	Yes	Yes	Yes	9	9
84	5x43	Lig	beta1_on	0.81662	47.728	No	No	Yes	Yes	6	0
85	5x39	5x43	beta1_on	0.0718921	46.7584	Yes	Yes	No	No	7	6
86	4x61	5x39	beta1_on	0	13.2645	Yes	No	Yes	Yes	6	7
87	3x30	4x61	beta1_on	4.09785	13.0989	No	No	Yes	No	6	6
88	3x30	4x58	beta1_on	1.41019	11.9185	No	No	No	Yes	6	5
89	3x28	Lig	beta1_on	0	26.1766	Yes	Yes	Yes	Yes	6	0
90	E2.T203	E2x52	beta1_on	0.759475	30.2689	No	No	Yes	Yes	4	4
91	E2.T203	E2.W182	beta1_on	0.0423979	23.5478	No	No	Yes	Yes	4	5
92	E2.R183	E2.W182	beta1_on	4.14762	37.6223	Yes	No	Yes	Yes	4	5
93	4x64	E2.R183	beta1_on	2.09593	10.6266	No	No	Yes	No	5	4
94	3x40	6x48	beta1_on	0	15.1646	No	No	Yes	Yes	8	8
95	5x47	6x52	beta1_on	2.27105	20.3921	No	Yes	Yes	Yes	7	7
96	5x47	6x44	beta1_on	0	15.9535	No	Yes	Yes	Yes	7	9
97	3x40	5x50	beta1_on	7.57447	10.6417	No	No	No	No	8	9
98	5x54	6x44	beta1_on	0	20.0187	No	No	Yes	Yes	8	9
99	5x54	6x41	beta1_on	5.56703	19.6814	No	No	Yes	No	8	8
100	5x58	6x41	beta1_on	1.85629	19.3773	No	Yes	Yes	No	9	8
101	5x57	5x58	beta1_on	0	16.7876	No	No	No	Yes	6	9
102	3x51	5x57	beta1_on	0	15.8481	No	Yes	No	No	8	6
103	E2.R183	E2.Y193	beta1_on	0.0940127	24.5777	Yes	No	Yes	No	4	3
104	5x36	5x39	beta1_on	5.7827	10.6688	No	No	Yes	Yes	5	7
105	E2.C192	E2.Y193	beta1_on	0	19.2207	No	No	Yes	No	4	3
106	E2.C192	E2.C198	beta1_on	0.00737354	16.4925	No	No	No	No	4	5
107	E2.C198	E2.D195	beta1_on	8.42612	11.0181	No	No	No	No	5	3
108	5x58	6x37	beta1_on	0	11.6896	No	Yes	No	No	9	8
109	5x62	6x37	beta1_on	0	10.8284	No	No	No	No	6	8
110	7x52	7x53	beta1_on	0	12.2467	No	No	Yes	Yes	8	9
111	3x50	7x53	beta1_on	0	16.3751	Yes	No	Yes	Yes	9	9
112	3x50	5x58	beta1_on	0	14.1558	Yes	No	No	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x39	7x39	Shared	3.49	21.52	0	0	2	1
2x56	3x32	Shared	6.57	8.76	1	1	2	1
2x56	7x42	Shared	5.68	4.42	1	1	2	1
2x57	7x39	Shared	3.675	2.45	3	0	2	1
2x59	E1x50	Shared	5.51	4.01	1	1	2	2
2x59	3x28	Shared	5.515	7.515	1	1	2	1
2x60	3x28	Shared	4.925	3.515	0	0	2	1
2x63	E1x50	beta1_off	6.83	0	0	0	1	2
2x64	7x39	Shared	3.68	4.9	0	0	2	1
3x28	E1x50	Shared	12.185	10.31	1	1	1	2
3x29	E2x52	Shared	6.485	3.24	0	0	2	1
3x32	7x42	Shared	10.34	13.215	1	1	1	1
3x32	Lig	Shared	18.89	16.595	1	1	1	0
3x33	4x57	beta1_off	5.655	0	0	0	1	2
3x33	4x61	beta1_off	3.84	0	0	0	1	2
3x33	Lig	Shared	8.67	13.1	0	0	1	0
3x36	6x48	Shared	11.65	9.81	1	1	1	1
3x36	Lig	Shared	3.655	6.11	1	1	1	0
3x37	4x57	beta1_off	6.395	0	7	0	2	2
3x37	5x461	Shared	7.995	9.59	7	0	2	1
3x40	6x44	Shared	8.165	5.02	0	0	2	2
4x61	E2.W182	Shared	4.7	11.16	1	6	2	2
4x61	E2x52	beta1_off	4.395	0	1	6	2	1
E2.W182	E2x52	beta1_off	10.02	0	1	6	2	1
E2.T203	E2.W182	Shared	5.46	3.64	1	0	2	2
5x39	E2.W182	Shared	5.79	6.27	1	6	1	2
E2.T203	E2x52	Shared	7.78	4.54	1	0	2	1
5x39	E2x52	beta1_off	5.16	0	1	6	1	1
E2x52	Lig	Shared	8.87	21.42	1	0	1	0
5x39	E2.T203	beta1_off	5.615	0	1	6	1	2
5x36	5x39	Shared	3.49	2.91	0	0	2	1
5x39	5x43	Shared	15.26	8.9	1	6	1	1
5x39	Lig	beta1_off	4.09	0	1	6	1	0
5x43	Lig	Shared	7.87	7.38	1	0	1	0
5x44	5x48	beta1_off	3.815	0	0	0	2	2
5x461	Lig	Shared	3.645	4.935	0	0	1	0
5x47	5x48	Shared	8.25	7.22	1	1	2	2
5x47	6x52	Shared	32.15	19.825	1	1	2	1
5x48	6x52	beta1_off	4.125	0	1	0	2	1
6x44	6x48	beta1_off	9.52	0	0	1	2	1
6x44	7x45	beta1_off	6.645	0	0	1	2	2
6x48	6x51	Shared	6.515	5.515	1	1	1	1
6x48	6x52	Shared	5.51	8.52	1	1	1	1
6x48	7x41	Shared	12.67	11.26	1	1	1	2
6x48	Lig	beta1_off	3.59	0	1	1	1	0
6x51	6x52	Shared	8.575	11.255	1	1	1	1
6x51	7x34	Shared	4.825	9.11	1	1	1	2
6x51	7x38	Shared	11.48	17.52	1	1	1	1
6x51	Lig	Shared	9.81	7.515	1	1	1	0
6x52	Lig	Shared	11.885	4.995	1	1	1	0
6x55	7x34	Shared	4.23	7.855	0	1	1	2
6x55	Lig	beta1_off	7.625	0	0	1	1	0
7x38	7x42	Shared	11.63	12.795	1	1	1	1
7x38	Lig	Shared	14.855	16.03	1	1	1	0
7x39	7x42	beta1_off	12.055	0	0	0	1	1
7x42	Lig	Shared	3.665	7.145	1	1	1	0
2x56	3x28	beta1_off	3.065	0	1	1	2	1
7x35	7x39	beta1_off	2.45	0	0	0	1	1
4x60	5x39	Shared	2.085	4.17	0	0	2	1
4x56	5x461	beta1_off	1.62	0	0	0	2	1
3x28	Lig	beta1_on	0	7.995	1	1	1	0
3x32	3x36	beta1_on	0	3.65	1	1	1	1
3x40	6x48	beta1_on	0	8.22	0	0	2	1
4x61	5x39	beta1_on	0	6.65	1	6	2	1
6x55	E2x52	beta1_on	0	3.625	0	1	1	1
5x44	6x52	beta1_on	0	4.62	0	0	2	1
5x44	6x55	beta1_on	0	3.725	0	0	2	1
5x47	6x44	beta1_on	0	5.36	1	1	2	2
6x48	7x45	beta1_on	0	7.91	1	1	1	2
2x63	Lig	beta1_on	0	3.68	0	0	1	0
6x51	6x55	beta1_on	0	3.625	1	1	1	1
7x35	Lig	beta1_on	0	3.96	0	0	1	0
7x39	Lig	beta1_on	0	3.785	0	0	1	0
3x37	4x56	beta1_on	0	3.17	7	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	beta1_off	2VT4-β₁-Cyanopindolol 2YCZ-β₁-Iodocyanopindolol
	beta1_on	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2

Network Difference
Value	beta1_off	beta1_on
I_min	3.17	3.53
Number of Linked Nodes	276	256
Number of Specific Nodes	26 (9.42%)	6 (2.34%)
Number of Shared Nodes	250 (90.58%)	250 (97.66%)
Number of Links	313	282
Number of Specific Links	134 (42.81%)	103 (36.52%)
Number of Shared Links	179 (57.19%)	179 (63.48%)
Number of Hubs	38	35
Number of Specific Hubs	17 (44.74%)	14 (40.00%)
Number of Shared Hubs	21 (55.26%)	21 (60.00%)
Average % Shared Neighbours (Jaccard)	45.75
Average % Shared Neighbours (Otsuka)	54.40
Average % Shared Neighbours (Overlap Coefficient)	62.94
Average % Shared Cliques (k3-6)	54.79
Graphlets Similarity	0.675142

Paths Difference
Value	beta1_off	beta1_on
Number Of Nodes in MetaPath	66	61
Specific Nodes in MetaPath	28 (42.42%)	23 (37.70%)
Shared Nodes in MetaPath	250 (90.58%)	250 (90.58%)
Number Of Links MetaPath	69	63
Specific Links in MetaPath	49 (71.01%)	43 (68.25%)
Shared Links in MetaPath	179 (57.19%)	179 (57.19%)
Number of Shortest Paths	105385	60479
Length Of Smallest Path	3	3
Average Path Length	17.2247	13.1133
Length of Longest Path	39	26
Minimum Path Strength	0.7225	0.755
Average Path Strength	5.79424	6.82015
Maximum Path Strength	22.0175	23.37
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.919539	0.921131
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	2.77778	5
Average % Of Corr. Nodes	39.7332	46.064
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	41.5024	44.7869
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download beta1_off_on.zip<

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