Orange: nodes, hubs and links specific of beta1_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta1_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner beta1_on_gp Avg Int. Strength beta1_off Avg Int. Strength beta1_on_gp Num Of Links beta1_off Num Of Links ConSurf
1b.1x4 beta1_on_gp500508
2b.1x7 beta1_on_gp00408
3b.1x11 beta1_on_gp00408
4b.1x15 beta1_on_gp500407
5b.lhb1x3 beta1_on_gp500502
6b.lhb1x6 beta1_on_gp500503
7b.lhb1x11 beta1_on_gp500404
8b.l1x3 beta1_on_gp1000609
9b.l1x6 beta1_on_gp500409
10b.b2x1 beta1_on_gp500508
11b.b2x3 beta1_on_gp500506
12b.b2x5 beta1_on_gp1000507
13b.b3x3 beta1_on_gp1000408
14b.l3x2 beta1_on_gp1000709
15b.b4x3 beta1_on_gp1000607
16b.b4x6 beta1_on_gp1000709
17b.l4x2 beta1_on_gp1000604
18b.b5x3 beta1_on_gp1000709
19b.b5x5 beta1_on_gp00405
20b.b5x7 beta1_on_gp1000407
21b.l5x1 beta1_on_gp1000408
22b.l5x5 beta1_on_gp1000609
23b.b6x1 beta1_on_gp500409
24b.b6x5 beta1_on_gp1000506
25b.b7x1 beta1_on_gp500404
26b.b7x4 beta1_on_gp1000408
27b.b8x3 beta1_on_gp500506
28b.b8x4 beta1_on_gp1000506
29b.b9x3 beta1_on_gp500406
30b.l9x3 beta1_on_gp1000609
31b.l9x6 beta1_on_gp1000708
32b.b10x5 beta1_on_gp500509
33b.b11x4 beta1_on_gp1000409
34b.l11x2 beta1_on_gp1000409
35b.b12x6 beta1_on_gp1000708
36b.b13x7 beta1_on_gp1000507
37b.l13x3 beta1_on_gp1000609
38b.l13x6 beta1_on_gp1000409
39b.b15x1 beta1_on_gp500509
40b.b15x2 beta1_on_gp1000406
41b.l15x1 beta1_on_gp1000407
42b.l15x2 beta1_on_gp1000409
43b.b16x4 beta1_on_gp1000406
44b.b16x5 beta1_on_gp500405
45b.b16x6 beta1_on_gp1000608
46b.b16x7 beta1_on_gp00409
47b.b17x5 beta1_on_gp500407
48b.b17x7 beta1_on_gp1000408
49b.l17x3 beta1_on_gp1000609
50b.l17x6 beta1_on_gp1000509
51b.b18x3 beta1_on_gp1000408
52b.b18x5 beta1_on_gp1000405
53b.l18x1 beta1_on_gp1000606
54b.l18x2 beta1_on_gp1000407
55b.l18x3 beta1_on_gp500405
56b.b19x2 beta1_on_gp1000606
57b.b19x4 beta1_on_gp500408
58b.l19x1 beta1_on_gp500409
59b.l19x2 beta1_on_gp500509
60b.b20x4 beta1_on_gp1000608
61b.b20x6 beta1_on_gp1000606
62b.b21x1 beta1_on_gp1000407
63b.b21x2 beta1_on_gp500406
64b.b21x3 beta1_on_gp00406
65b.b21x5 beta1_on_gp500404
66b.b21x7 beta1_on_gp1000605
67b.l21x2 beta1_on_gp500404
68b.l21x5 beta1_on_gp00404
69b.b22x5 beta1_on_gp500607
70b.l22x5 beta1_on_gp1000509
71b.b23x6 beta1_on_gp1000507
72b.l23x1 beta1_on_gp500506
73b.b24x4 beta1_on_gp1000506
74b.b24x6 beta1_on_gp1000408
75b.l24x2 beta1_on_gp00406
76b.l24x3 beta1_on_gp500405
77b.l25x3 beta1_on_gp1000509
78b.l25x6 beta1_on_gp500508
79b.l26x5 beta1_on_gp1000405
80b.l27x1 beta1_on_gp1000709
81b.l27x2 beta1_on_gp500409
82b.b28x2 beta1_on_gp00404
83b.b28x3 beta1_on_gp1000607
84b.b28x4 beta1_on_gp1000406
85b.b28x6 beta1_on_gp1000509
86b.b28x7 beta1_on_gp1000409
87G.S1.02 beta1_on_gp1000406
88G.S1.06 beta1_on_gp00408
89G.S2.01 beta1_on_gp00409
90G.S3.01 beta1_on_gp500406
91G.S3.04 beta1_on_gp500407
92G.S3.05 beta1_on_gp500408
93G.S3.06 beta1_on_gp1000506
94G.S3.07 beta1_on_gp00409
95G.s3h2.03 beta1_on_gp00409
96G.H2.04 beta1_on_gp00409
97G.H2.06 beta1_on_gp1000609
98G.H2.07 beta1_on_gp1000609
99G.H2.09 beta1_on_gp500408
100G.h2s4.01 beta1_on_gp1000509
101G.h2s4.02 beta1_on_gp00408
102G.S4.02 beta1_on_gp00408
103G.S4.03 beta1_on_gp500408
104G.S4.04 beta1_on_gp500509
105G.s4h3.01 beta1_on_gp00407
106G.H3.03 beta1_on_gp00404
107G.H3.06 beta1_on_gp00406
108G.H3.09 beta1_on_gp1000509
109G.H3.13 beta1_on_gp500506
110G.H3.17 beta1_on_gp1000705
111G.H3.18 beta1_on_gp500509
112G.S5.03 beta1_on_gp500409
113G.S5.04 beta1_on_gp500409
114G.S5.05 beta1_on_gp1000509
115G.HG.01 beta1_on_gp500506
116G.hgh4.02 beta1_on_gp1000708
117G.hgh4.05 beta1_on_gp500406
118G.H4.03 beta1_on_gp500404
119G.H4.05 beta1_on_gp00405
120G.H4.10 beta1_on_gp500406
121G.H4.12 beta1_on_gp500405
122G.H4.14 beta1_on_gp500406
123G.H4.15 beta1_on_gp500408
124G.S6.02 beta1_on_gp1000508
125G.S6.04 beta1_on_gp500409
126G.S6.05 beta1_on_gp500505
127G.s6h5.01 beta1_on_gp500409
128G.H5.03 beta1_on_gp500409
129G.H5.08 beta1_on_gp1000509
130G.H5.17 beta1_on_gp500506
131G.H5.20 beta1_on_gp500408
132G.H5.25 beta1_on_gp1000509
133G.H5.26 beta1_on_gp500607
134g.h1x11 beta1_on_gp00409
135g.l1x4 beta1_on_gp00408
136g.h2x11 beta1_on_gp1000406
137g.ctx3 beta1_on_gp1000509
138g.ctx14 beta1_on_gp1000409
139g.ctx15 beta1_on_gp1000409
140g.ctx16 beta1_on_gp1000808
141g.ctx17 beta1_on_gp500407
1422x46 beta1_on_gp1000429
1433x32 beta1_on_gp1000437
1443x33 beta1_on_gp500426
1453x51 beta1_on_gp500438
146I2x51 beta1_on_gp1000626
1474x58 beta1_on_gp5016.6667635
1484x61 beta1_on_gp10033.3333436
149E2.R183 beta1_on_gp10033.3333434
150E2.D184 beta1_on_gp00534
151E2.T203 beta1_on_gp5016.6667434
1525x47 beta1_on_gp10016.6667637
1535x58 beta1_on_gp1000719
1545x60 beta1_on_gp500435
1556x29 beta1_on_gp00436
1566x49 beta1_on_gp1000417
1576x54 beta1_on_gp500434
1586x55 beta1_on_gp1000426
1597x34 beta1_on_gp1000434
1607x49 beta1_on_gp10033.3333539
1611x46 Shared500447
1621x57 Shared5016.6667447
1632x40 Shared5033.3333449
1642x42 Shared100100568
1652x50 Shared10016.6667549
166E1x50 Shared100100677
167E1x52 Shared50100455
1683x28 Shared10033.3333446
1693x34 Shared500445
1703x37 Shared5050446
1713x49 Shared10066.6667449
1723x50 Shared100100469
1734x50 Shared00449
174E2.W182 Shared100100565
175E2.Y193 Shared00443
176E2x52 Shared0100464
1775x39 Shared100100677
1786x44 Shared100100459
1796x48 Shared100100768
1806x51 Shared100100657
1816x52 Shared100100667
182E3.V320 Shared10033.3333545
1837x39 Shared083.3333556
1847x42 Shared100100567
1857x53 Shared10083.3333459
1868x50 Shared100100668
187Lig Shared10010015130
188I1x50 beta1_off5016.6667348
1892x56 beta1_off033.3333247
1903x41 beta1_off066.6667356
191I2x53 beta1_off0100357
1925x48 beta1_off050255
1935x68 beta1_off500347
1946x31 beta1_off033.3333145
1956x59 beta1_off00245
1967x33 beta1_off033.3333344
1978x54 beta1_off500247
   
Orange: nodes, hubs and links specific of beta1_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta1_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner beta1_on_gp Recurrence beta1_off Recurrence beta1_on_gp Hub1? beta1_off Hub1? beta1_on_gp Hub2? beta1_off Hub2? ConSurf1 ConSurf2
1b.1x10 b.1x9 beta1_on_gp12.19090NoNoNoNo14
2b.1x10 b.1x11 beta1_on_gp13.55350NoNoYesNo18
3b.1x11 b.1x7 beta1_on_gp13.46590YesNoYesNo88
4b.1x15 g.h1x11 beta1_on_gp35.13510YesNoYesNo79
5b.1x11 g.h1x11 beta1_on_gp31.06230YesNoYesNo89
6b.1x15 b.1x19 beta1_on_gp13.53530YesNoNoNo76
7b.1x15 g.l1x4 beta1_on_gp27.02860YesNoYesNo78
8b.1x19 b.b21x1 beta1_on_gp15.77680NoNoYesNo67
9b.b21x1 g.l1x4 beta1_on_gp14.41640YesNoYesNo78
10b.b17x5 b.b21x1 beta1_on_gp30.63090YesNoYesNo77
11b.b16x5 b.b17x5 beta1_on_gp45.50860YesNoYesNo57
12b.b15x2 b.b16x5 beta1_on_gp50.24520YesNoYesNo65
13b.b15x2 b.b18x5 beta1_on_gp63.0850YesNoYesNo65
14b.b18x5 b.l18x4 beta1_on_gp64.350YesNoNoNo57
15b.l18x3 b.l18x4 beta1_on_gp65.19160YesNoNoNo57
16b.l18x1 b.l18x3 beta1_on_gp67.97050YesNoYesNo65
17b.b22x5 b.l18x1 beta1_on_gp71.37840YesNoYesNo76
18b.b22x5 b.b23x2 beta1_on_gp75.56730YesNoNoNo76
19b.b21x7 b.b23x2 beta1_on_gp75.97890YesNoNoNo56
20b.b21x5 b.b21x7 beta1_on_gp85.29090YesNoYesNo45
21g.l1x2 g.l1x4 beta1_on_gp14.41470NoNoYesNo28
22b.b17x5 g.l1x2 beta1_on_gp14.86230YesNoNoNo72
23b.b21x5 b.h2x1 beta1_on_gp88.91250YesNoNoNo45
24b.h2x1 b.h2x5 beta1_on_gp91.48070NoNoNoNo55
25b.h2x5 b.l24x2 beta1_on_gp91.87970NoNoYesNo56
26b.l22x5 b.l24x2 beta1_on_gp92.27940YesNoYesNo96
27b.l22x5 b.lhb1x6 beta1_on_gp90.69370YesNoYesNo93
28b.lhb1x6 b.lhb1x9 beta1_on_gp95.06630YesNoNoNo33
29b.lhb1x11 b.lhb1x9 beta1_on_gp95.79480YesNoNoNo43
30b.b28x7 b.lhb1x11 beta1_on_gp15.6210YesNoYesNo94
31b.b25x7 b.lhb1x11 beta1_on_gp1000NoNoYesNo74
32b.b25x7 b.b28x6 beta1_on_gp57.7030NoNoYesNo79
33b.b28x4 b.b28x6 beta1_on_gp29.70050YesNoYesNo69
34b.b28x7 g.ctx16 beta1_on_gp12.18350YesNoYesNo98
35b.b2x5 b.l4x1 beta1_on_gp21.38860YesNoNoNo75
36b.b2x3 b.b2x5 beta1_on_gp21.47080YesNoYesNo67
37b.b27x3 b.b28x6 beta1_on_gp29.69920NoNoYesNo89
38b.b27x3 b.l25x3 beta1_on_gp36.22750NoNoYesNo89
39b.l25x3 b.l27x2 beta1_on_gp64.25140YesNoYesNo99
40b.b28x4 b.l25x3 beta1_on_gp29.42230YesNoYesNo69
41b.b24x3 b.b25x7 beta1_on_gp42.60030NoNoNoNo57
42b.b24x3 b.b26x3 beta1_on_gp43.02430NoNoNoNo56
43b.b22x2 b.b26x3 beta1_on_gp51.55840NoNoNoNo86
44b.b22x1 b.b22x2 beta1_on_gp51.74180NoNoNoNo88
45b.b22x1 b.l25x6 beta1_on_gp30.39830NoNoYesNo88
46G.H2.09 b.b2x1 beta1_on_gp12.61830YesNoYesNo88
47G.H3.17 b.l25x6 beta1_on_gp21.42560YesNoYesNo58
48G.H3.17 b.l23x1 beta1_on_gp22.0330YesNoYesNo56
49b.b22x1 b.l23x1 beta1_on_gp21.5530NoNoYesNo86
50b.b2x1 b.b6x1 beta1_on_gp14.97410YesNoYesNo89
51b.b26x2 b.b2x3 beta1_on_gp23.22390NoNoYesNo76
52b.b6x1 b.l9x6 beta1_on_gp16.86320YesNoYesNo98
53b.l11x1 b.l9x6 beta1_on_gp25.1320NoNoYesNo98
54b.b11x6 b.l11x1 beta1_on_gp25.03730NoNoNoNo99
55b.b11x6 b.l9x3 beta1_on_gp23.43670NoNoYesNo99
56b.b11x4 b.l9x3 beta1_on_gp12.98720YesNoYesNo99
57b.b10x3 b.b11x4 beta1_on_gp13.01020NoNoYesNo89
58b.b10x3 b.b6x2 beta1_on_gp12.74110NoNoNoNo88
59b.b10x2 b.b6x2 beta1_on_gp12.47170NoNoNoNo68
60b.b10x2 b.b14x3 beta1_on_gp12.2020NoNoNoNo65
61b.l2x5 b.l4x2 beta1_on_gp25.36040NoNoYesNo54
62b.l2x3 b.l2x5 beta1_on_gp25.35920NoNoNoNo85
63b.b3x1 b.l2x3 beta1_on_gp25.07870NoNoNoNo58
64b.b3x1 b.b6x5 beta1_on_gp18.30750NoNoYesNo56
65b.b3x3 b.b6x5 beta1_on_gp17.16580YesNoYesNo86
66b.b3x3 b.b4x3 beta1_on_gp16.29860YesNoYesNo87
67G.S1.03 G.S3.06 beta1_on_gp10.89460NoNoYesNo96
68G.S1.03 G.hns1.01 beta1_on_gp10.73880NoNoNoNo93
69G.H2.07 b.l9x6 beta1_on_gp15.23010YesNoYesNo98
70G.H2.08 G.H3.18 beta1_on_gp60.72540NoNoYesNo99
71G.H3.15 G.H3.18 beta1_on_gp59.63720NoNoYesNo89
72G.H3.15 G.H3.17 beta1_on_gp59.62970NoNoYesNo85
73b.l25x4 b.l27x2 beta1_on_gp63.1360NoNoYesNo59
74b.b26x1 b.b26x2 beta1_on_gp23.29860NoNoNoNo97
75G.H5.17 G.S6.02 beta1_on_gp12.87380YesNoYesNo68
76G.S6.02 G.h4s6.12 beta1_on_gp16.75850YesNoNoNo82
77G.h3s5.02 G.h4s6.12 beta1_on_gp50.30210NoNoNoNo42
78G.h3s5.02 G.h3s5.03 beta1_on_gp50.42090NoNoNoNo47
79G.H3.18 G.h3s5.03 beta1_on_gp47.59750YesNoNoNo97
80G.H5.10 G.S6.02 beta1_on_gp15.51880NoNoYesNo78
81G.H2.04 G.H2.08 beta1_on_gp52.26240YesNoNoNo99
82G.H2.04 G.H3.08 beta1_on_gp64.26710YesNoNoNo99
83G.H3.08 G.S4.04 beta1_on_gp64.07110NoNoYesNo99
84G.S4.04 G.S4.06 beta1_on_gp13.27960YesNoNoNo97
85G.H3.09 G.S4.04 beta1_on_gp29.08460YesNoYesNo99
86G.S4.04 G.S5.04 beta1_on_gp21.57330YesNoYesNo99
87G.H4.15 G.S4.06 beta1_on_gp12.80730YesNoNoNo87
88G.H3.09 G.H4.15 beta1_on_gp13.00210YesNoYesNo98
89G.H4.15 G.S5.04 beta1_on_gp12.99570YesNoYesNo89
90G.H3.03 G.H3.07 beta1_on_gp10.70230YesNoNoNo45
91G.H3.03 G.hgh4.02 beta1_on_gp17.55030YesNoYesNo48
92G.H3.06 G.hgh4.02 beta1_on_gp35.86090YesNoYesNo68
93G.H3.06 G.H4.15 beta1_on_gp37.80790YesNoYesNo68
94G.H3.06 G.h4s6.01 beta1_on_gp12.68140YesNoNoNo65
95G.H3.09 G.h4s6.01 beta1_on_gp13.16580YesNoNoNo95
96G.H3.06 G.H4.14 beta1_on_gp13.62290YesNoYesNo66
97G.H4.10 G.hgh4.05 beta1_on_gp15.68960YesNoYesNo66
98G.H4.10 G.hgh4.02 beta1_on_gp11.82160YesNoYesNo68
99G.H4.10 G.H4.14 beta1_on_gp11.67130YesNoYesNo66
100G.H5.21 G.h4s6.12 beta1_on_gp33.46290NoNoNoNo52
101G.H5.21 G.H5.26 beta1_on_gp33.31580NoNoYesNo57
1022x39 3x49 beta1_on_gp54.87241.2735NoNoYesYes89
1032x37 2x39 beta1_on_gp54.840NoNoNoNo78
1042x37 2x40 beta1_on_gp54.85571.84289NoNoYesYes79
1052x40 I1x50 beta1_on_gp53.83430.107145YesYesNoYes98
1061x60 I1x50 beta1_on_gp57.51725.31439NoNoNoYes68
1071x60 8x56 beta1_on_gp57.98713.46538NoNoNoNo64
1088x56 b.l25x4 beta1_on_gp58.32230NoNoNoNo45
109G.H5.20 G.H5.26 beta1_on_gp40.09040YesNoYesNo87
110G.H5.20 G.H5.25 beta1_on_gp39.45240YesNoYesNo89
111G.H5.23 G.H5.25 beta1_on_gp12.00570NoNoYesNo49
1123x50 G.H5.23 beta1_on_gp11.92740YesYesNoNo94
1133x46 3x50 beta1_on_gp38.5910NoNoYesYes99
1142x42 3x46 beta1_on_gp38.55664.2858YesYesNoNo89
1156x37 G.H5.25 beta1_on_gp27.09150NoNoYesNo89
1166x48 7x45 beta1_on_gp25.34980YesYesNoNo89
1177x45 7x49 beta1_on_gp25.72010NoNoYesNo99
1183x50 7x53 beta1_on_gp32.31390YesYesYesYes99
1196x48 6x51 beta1_on_gp15.09914.57356YesYesYesYes87
1205x47 6x52 beta1_on_gp21.48219.2359YesNoYesYes77
1215x47 6x44 beta1_on_gp27.49210YesNoYesYes79
1225x54 6x44 beta1_on_gp32.60080NoNoYesYes89
1235x54 5x58 beta1_on_gp32.77380NoNoYesNo89
1243x50 5x58 beta1_on_gp10.48120YesYesYesNo99
1253x38 4x53 beta1_on_gp15.3033.946NoNoNoNo78
1263x38 4x50 beta1_on_gp15.52823.21129NoNoYesYes79
1273x28 Lig beta1_on_gp14.7160YesYesYesYes60
128E2.R183 E2.W182 beta1_on_gp14.62596.56646YesNoYesYes45
129E2.R183 E2.Y193 beta1_on_gp10.77540.113268YesNoYesYes43
130b.b26x1 b.l27x1 beta1_on_gp23.37530NoNoYesNo99
131G.H3.17 b.l27x1 beta1_on_gp16.22670YesNoYesNo59
1325x58 6x37 beta1_on_gp26.28220YesNoNoNo98
133b.l4x1 b.l4x2 beta1_on_gp15.79240NoNoYesNo54
134G.H2.04 G.H2.07 beta1_on_gp12.41330YesNoYesNo99
1352x42 3x49 Shared55.185571.7474YesYesYesYes89
1367x49 7x53 Shared29.560952.0511YesNoYesYes99
1376x52 Lig Shared24.008714.3972YesYesYesYes70
1382x45 4x50 Shared16.211371.7474NoNoYesYes99
1392x45 4x46 Shared18.752380.2853NoNoNoNo97
1402x42 4x46 Shared20.51979.2537YesYesNoNo87
1413x28 E1x50 Shared12.715739.8671YesYesYesYes67
142E1x50 E1x52 Shared10.051331.8098YesYesYesYes75
143E2.W182 E2x52 Shared10.719716.084YesYesYesYes54
144E2x52 Lig Shared15.360828.7914YesYesYesYes40
1451x35 2x65 beta1_off013.9135NoNoNoNo45
1461x32 2x65 beta1_off020.8229NoNoNoNo05
1471x32 2x66 beta1_off036.166NoNoNoNo04
1482x66 E1x51 beta1_off2.016239.6039NoNoNoNo44
149E1x51 E1x52 beta1_off8.0470849.8347NoNoYesYes45
1502x59 E1x52 beta1_off031.5741NoNoYesYes45
1512x59 3x28 beta1_off0.66908533.2425NoNoYesYes46
1522x56 3x28 beta1_off076.0424NoYesYesYes76
1532x56 7x42 beta1_off0.15967684.4609NoYesYesYes77
1542x53 2x56 beta1_off0100NoNoNoYes87
1552x53 7x46 beta1_off1.5891695.5642NoNoNoNo89
1561x46 7x46 beta1_off1.9859910.9441YesYesNoNo79
1572x56 3x32 beta1_off0.65878975.975NoYesYesNo77
1583x32 Lig beta1_off0.31243176.3607YesNoYesYes70
1593x33 Lig beta1_off2.9074172.3749YesNoYesYes60
1603x33 4x57 beta1_off5.9063171.579YesNoNoNo67
1613x34 4x57 beta1_off4.9551872.0994YesYesNoNo57
1623x34 4x58 beta1_off2.7367714.737YesYesYesNo55
1633x31 4x58 beta1_off0.62199215.6187NoNoYesNo55
1642x551 3x31 beta1_off0.31108111.1859NoNoNoNo45
1657x42 Lig beta1_off0.80850682.4558YesYesYesYes70
1664x61 E2x52 beta1_off010.8431YesNoYesYes64
1673x30 4x61 beta1_off1.902115.2973NoNoYesNo66
1683x30 4x58 beta1_off1.8862313.7574NoNoYesNo65
1692x50 7x46 beta1_off3.966484.9997YesYesNoNo99
1701x50 2x50 beta1_off3.1757913.9197NoNoYesYes99
1712x50 7x49 beta1_off5.7859668.9769YesYesYesNo99
1727x53 8x50 beta1_off048.5336YesYesYesYes98
1738x50 8x54 beta1_off3.2802716.1514YesYesNoYes87
1748x50 I1x50 beta1_off3.5299110.7053YesYesNoYes88
1753x34 4x50 beta1_off070.4494YesYesYesYes59
1763x49 I2x53 beta1_off1.3785111.2227YesYesNoYes97
1773x49 3x50 beta1_off058.3328YesYesYesYes99
1786x48 Lig beta1_off021.1719YesYesYesYes80
1796x44 6x48 beta1_off027.7353YesYesYesYes98
1803x43 6x44 beta1_off020.3147NoNoYesYes89
1812x46 3x43 beta1_off0.27124612.3247YesNoNoNo98
1822x46 3x42 beta1_off2.6520311.5227YesNoNoNo98
1835x39 Lig beta1_off038.162YesYesYesYes70
1845x39 E2.W182 beta1_off1.6303517.734YesYesYesYes75
1855x461 Lig beta1_off6.0713914.1278NoNoYesYes60
1863x37 5x461 beta1_off7.566212.3829YesYesNoNo66
1873x43 5x54 beta1_off011.789NoNoNoNo88
1883x50 6x34 beta1_off056.196YesYesNoNo97
1895x61 6x34 beta1_off055.1368NoNoNoNo97
1903x51 5x61 beta1_off053.9705YesNoNoNo89
1913x51 3x55 beta1_off1.3484749.2316YesNoNoNo87
1923x55 5x64 beta1_off037.0569NoNoNoNo76
1933x54 5x64 beta1_off030.6894NoNoNoNo96
1943x54 5x68 beta1_off029.3547NoNoNoYes97
1953x55 3x56 beta1_off1.0814412.4747NoNoNoNo76
196E2.W182 E2.Y193 beta1_off028.9016YesYesYesYes53
1975x36 5x39 beta1_off015.7442NoNoYesYes57
1985x36 E2.D184 beta1_off2.1502213.1482NoNoYesNo54
199E2.A189 E2.Y193 beta1_off0.18161820.4127NoNoYesYes43
200E2.A189 E2.V202 beta1_off1.6527918.1687NoNoNoNo44
201E2.V202 E2x51 beta1_off015.9187NoNoNoNo45
202E2.C198 E2x51 beta1_off0.67212313.6625NoNoNoNo55
2036x40 7x49 beta1_off015.3432NoNoYesNo89
2046x40 7x52 beta1_off014.5197NoNoNoNo88
2056x51 Lig beta1_off6.6915219.1024YesYesYesYes70
2066x51 7x34 beta1_off8.853928.1945YesYesYesNo74
2076x54 7x34 beta1_off4.14643.1121YesNoYesNo44
2086x54 7x37 beta1_off015.4473YesNoNoNo45
2096x55 Lig beta1_off0.38585519.0167YesNoYesYes60
2106x55 7x34 beta1_off0.21942717.9544YesNoYesNo64
2116x54 E3.V320 beta1_off2.8447924.6954YesNoYesYes45
2126x57 E3.V320 beta1_off0.0023630612.4258NoNoYesYes55
2138x47 8x50 beta1_off3.9753510.7359NoNoYesYes88
2145x68 6x20 beta1_off017.9269NoYesNoNo70
2156x20 6x22 beta1_off016.7269NoNoNoNo00
2161x29 1x32 beta1_off012.3921NoNoNoNo00
2172x45 3x42 beta1_off2.5181810.8339NoNoNoNo98

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
1x397x39Shared7.5616711.050021
2x563x32Shared6.813337.31221
2x567x42Shared5.473.791221
2x577x39Shared4.086673.0651021
2x577x42beta1_off3.5783301021
2x59E1x50Shared5.511674.011222
2x593x28Shared7.016679.021221
2x603x28Shared5.163.5150021
2x63E1x50beta1_off4.1766700012
2x647x39Shared4.086673.0650021
3x28E1x50Shared10.9357.4951212
3x29E2x52Shared8.433.240021
3x327x42Shared10.723313.2151211
3x32LigShared18.9816.5951210
3x334x57Shared5.3853.230212
3x33LigShared11.981713.10210
3x366x48Shared9.603339.811211
3x36LigShared4.421676.7151210
3x374x57beta1_off3.7316704022
3x375x461Shared8.791678.794021
3x406x44Shared7.153335.650022
4x61E2.W182Shared5.676676.461222
4x61E2x52beta1_off3.5583301221
E2.W182E2x52Shared10.02333.0051221
E2.T203E2.W182Shared4.0453.641222
5x39E2.W182Shared6.434.341212
E2.T203E2x52Shared7.783.891221
5x39E2x52beta1_off5.8466701211
E2x52LigShared9.5466719.441210
5x39E2.T203Shared5.6153.1251212
5x365x39beta1_off3.4900021
5x395x43Shared14.83678.2651211
5x39Ligbeta1_off4.1416701210
5x43LigShared7.723337.381010
5x445x48beta1_off3.3901022
5x446x52Shared3.34.621021
5x461LigShared3.426674.3250210
5x475x48Shared8.766676.7051222
5x476x52Shared32.1520.361221
5x486x52beta1_off3.2633301021
6x446x48beta1_off10.356700221
6x447x45beta1_off7.2500222
6x486x51Shared6.013336.0151211
6x486x52Shared5.017.521211
6x487x41Shared12.29.851212
6x48Ligbeta1_off3.9366701210
6x516x52Shared9.2912.861211
6x517x34Shared6.073338.0351212
6x517x38Shared10.471713.8951211
6x51LigShared9.718338.511210
6x52LigShared11.50335.9851210
6x557x34Shared4.236.040212
6x55LigShared7.976674.6150210
7x387x42Shared12.988313.9551211
7x38LigShared12.301716.031210
7x397x42Shared13.186.271211
7x42LigShared4.408337.621210
2x563x28beta1_off2.8601221
7x357x39beta1_off2.4500011
4x605x39Shared1.853334.8650021
4x565x461beta1_off1.6200021
7x317x35beta1_off0.24333300021
2x63Ligbeta1_on_gp03.680010
3x28Ligbeta1_on_gp08.921210
3x323x36beta1_on_gp03.651211
3x334x61beta1_on_gp03.070212
3x335x39beta1_on_gp03.1550211
3x406x48beta1_on_gp09.3950021
4x615x39beta1_on_gp06.651221
5x446x55beta1_on_gp05.961021
5x4616x52beta1_on_gp04.6250211
5x476x44beta1_on_gp06.971222
5x476x48beta1_on_gp04.511221
6x487x45beta1_on_gp06.781212
6x516x55beta1_on_gp06.041211
7x35Ligbeta1_on_gp03.960010
7x39Ligbeta1_on_gp03.7851210
3x374x56beta1_on_gp01.5854022

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
beta1_on_gp 8DCR-β1-Dobutamine-Gs/β1/γ2
7S0F-β1-Isoprenaline-Gi1/β1/γ2
beta1_off 2VT4-β1-Cyanopindolol
2YCW-β1-S-Carazolol
2YCZ-β1-Iodocyanopindolol
5A8E-β1-7-Methylcyanopindolol-Na
3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
Network Difference
Value beta1_on_gp beta1_off
Imin 2.8 3.18667
Number of Linked Nodes 874 292
Number of Specific Nodes 611 (69.91%) 29  (9.93%)
Number of Shared Nodes 263 (30.09%) 263  (90.07%)
Number of Links 1091 329
Number of Specific Links 898 (82.31%) 136  (41.34%)
Number of Shared Links 193 (17.69%) 193  (58.66%)
Number of Hubs 187 37
Number of Specific Hubs 160 (85.56%) 10  (27.03%)
Number of Shared Hubs 27 (14.44%) 27  (72.97%)
Average % Shared Neighbours (Jaccard) 14.63
Average % Shared Neighbours (Otsuka) 17.49
Average % Shared Neighbours (Overlap Coefficient) 20.04
Average % Shared Cliques (k3-6) 51.83
Graphlets Similarity 0.780686
Paths Difference
Value beta1_on_gp beta1_off
Number Of Nodes in MetaPath 136 78
Specific Nodes in MetaPath 115 (84.56%) 57  (73.08%)
Shared Nodes in MetaPath 263 (30.09%) 263  (30.09%)
Number Of Links MetaPath 144 83
Specific Links in MetaPath 134 (93.06%) 73  (87.95%)
Shared Links in MetaPath 193 (17.69%) 193  (17.69%)
Number of Shortest Paths 1350034 84483
Length Of Smallest Path 3 3
Average Path Length 28.5067 15.1531
Length of Longest Path 61 36
Minimum Path Strength 0.7175 0.575556
Average Path Strength 5.95689 6.20999
Maximum Path Strength 25.43 21.9283
Minimum Path Correlation 0.7 0.7
Average Path Correlation 0.977111 0.922084
Maximum Path Correlation 1 0.99
Minimum % Of Corr. Nodes 1.96078 2.94118
Average % Of Corr. Nodes 43.0464 43.2036
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 54.1409 42.3338
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download beta1_off_on_gp.zip<



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