psnGPCR

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Orange: nodes, hubs and links specific of beta_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	beta_off Int. Strength	beta_on Int. Strength	beta_off Hub1?	beta_on Hub1?	beta_off Hub2?	beta_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x61	beta_off	100	0	No	No	No	No	6	6
2	1x53	7x53	beta_off	100	0	No	No	Yes	Yes	9	9
3	8x49	I1x50	beta_off	100	0	No	No	No	No	6	8
4	2x39	3x50	beta_off	100	0	No	No	Yes	No	8	9
5	2x42	3x46	beta_off	100	0	Yes	Yes	No	No	8	9
6	2x43	7x53	beta_off	100	0	No	No	Yes	Yes	7	9
7	2x53	2x56	beta_off	100	0	No	No	No	No	8	7
8	2x59	E1x50	beta_off	100	0	Yes	No	Yes	Yes	4	7
9	2x59	3x24	beta_off	100	0	Yes	No	No	No	4	4
10	2x62	E1x52	beta_off	100	0	No	No	Yes	Yes	4	5
11	3x24	3x27	beta_off	100	0	No	No	Yes	No	4	4
12	3x26	4x62	beta_off	100	0	No	No	No	No	6	4
13	3x26	4x64	beta_off	100	0	No	No	No	No	6	5
14	3x29	E2x52	beta_off	100	0	No	No	Yes	No	6	4
15	3x34	4x50	beta_off	100	0	No	No	Yes	No	5	9
16	3x37	4x57	beta_off	100	0	No	No	No	No	6	7
17	3x39	6x44	beta_off	100	0	No	No	Yes	Yes	9	9
18	3x41	4x53	beta_off	100	0	Yes	No	No	No	6	8
19	3x43	6x44	beta_off	100	0	No	No	Yes	Yes	8	9
20	3x49	3x50	beta_off	100	0	Yes	No	Yes	No	9	9
21	3x50	3x53	beta_off	100	0	Yes	No	No	No	9	8
22	3x54	5x68	beta_off	100	0	No	No	No	No	9	7
23	4x58	4x62	beta_off	100	0	No	Yes	No	No	5	4
24	5x39	E2x52	beta_off	100	0	Yes	Yes	Yes	No	7	4
25	5x37	E3	beta_off	100	0	No	No	Yes	Yes	5	4
26	5x41	6x59	beta_off	100	0	No	No	Yes	No	5	5
27	5x51	6x45	beta_off	100	0	No	No	No	No	6	5
28	5x54	6x41	beta_off	100	0	No	No	Yes	No	8	8
29	5x65	6x31	beta_off	100	0	No	No	Yes	No	8	5
30	6x35	7x55	beta_off	100	0	No	No	No	Yes	7	7
31	6x40	7x49	beta_off	100	0	No	No	No	Yes	8	9
32	6x40	7x52	beta_off	100	0	No	No	No	No	8	8
33	6x40	7x53	beta_off	100	0	No	No	Yes	Yes	8	9
34	6x44	6x48	beta_off	100	0	Yes	Yes	Yes	Yes	9	8
35	6x44	7x45	beta_off	100	0	Yes	Yes	No	No	9	9
36	6x48	Lig	beta_off	100	0	Yes	Yes	Yes	Yes	8	0
37	6x55	Lig	beta_off	100	0	No	No	Yes	Yes	6	0
38	7x32	7x33	beta_off	100	0	No	No	No	No	3	4
39	7x49	7x53	beta_off	100	0	No	Yes	Yes	Yes	9	9
40	7x53	8x50	beta_off	100	0	Yes	Yes	Yes	Yes	9	8
41	8x48	8x51	beta_off	100	0	No	No	No	No	6	8
42	2x41	4x43	beta_off	100	0	No	No	No	No	5	4
43	6x29	6x30	beta_off	100	0	No	No	No	No	6	7
44	2x38	I2x55	beta_off	100	0	No	No	No	No	6	5
45	3x49	I2x55	beta_off	100	0	Yes	No	No	No	9	5
46	I2x52	I2x53	beta_off	100	0	No	No	Yes	Yes	5	7
47	5x68	I2x52	beta_off	100	0	No	No	No	No	7	5
48	6x30	I2x53	beta_off	100	0	No	No	Yes	Yes	7	7
49	6x31	I2x53	beta_off	100	0	Yes	No	Yes	Yes	5	7
50	5x58	5x61	beta_off	100	0	Yes	Yes	No	No	9	9
51	5x58	5x62	beta_off	100	0	Yes	Yes	No	Yes	9	6
52	6x26	6x35	beta_off	100	0	No	No	No	No	0	7
53	6x28	6x30	beta_off	100	0	No	No	No	No	0	7
54	6x28	6x31	beta_off	100	0	No	No	Yes	No	0	5
55	3x50	6x34	beta_off	71.4286	0	Yes	No	No	No	9	7
56	8x58	CT	beta_off	75	0	No	No	No	No	6	0
57	6x54	7x37	beta_off	50	0	No	No	No	Yes	4	5
58	3x48	5x57	beta_off	50	0	No	No	No	No	6	6
59	1x43	2x57	beta_off	25	0	No	No	No	No	5	7
60	3x45	4x45	beta_off	0	0	No	No	No	No	5	6
61	6x43	7x45	beta_off	14.2857	0	No	No	No	No	6	9
62	3x46	6x37	beta_off	32.1429	0	No	No	No	No	9	8
63	3x46	6x41	beta_off	0	0	No	No	Yes	No	9	8
64	3x55	5x64	beta_off	21.4286	0	No	No	No	No	7	6
65	7x54	8x54	beta_off	0	0	No	No	No	No	6	7
66	3x56	I2x56	beta_off	50	0	Yes	No	No	No	6	5
67	5x66	6x25	beta_off	50	0	No	No	No	No	5	0
68	4x41	I2x57	beta_off	50	0	No	No	No	No	7	6
69	3x47	5x57	beta_off	25	0	No	No	No	No	8	6
70	E1x49	E1x51	beta_off	21.4286	0	No	No	No	No	3	4
71	7x31	E2x51	beta_off	50	0	No	No	No	No	3	5
72	3x47	6x41	beta_off	25	0	No	No	Yes	No	8	8
73	3x27	3x31	beta_off	50	0	Yes	No	No	No	4	5
74	3x56	I2x51	beta_off	50	0	Yes	No	No	No	6	6
75	6x47	7x40	beta_off	0	0	No	No	No	No	8	7
76	3x23	3x27	beta_off	39.2857	0	No	No	Yes	No	2	4
77	6x29	6x32	beta_off	50	0	No	No	No	No	6	8
78	1x52	8x57	beta_off	14.2857	0	No	No	No	No	6	6
79	7x35	7x39	beta_off	0	0	No	No	Yes	Yes	4	6
80	5x69	6x31	beta_off	50	0	No	No	Yes	No	5	5
81	6x26	I2x54	beta_off	50	0	No	No	No	No	0	5
82	5x41	5x45	beta_off	0	0	No	No	No	No	5	4
83	3x44	5x54	beta_off	25	0	No	No	No	No	6	8
84	6x59	6x60	beta_off	25	0	Yes	No	No	No	5	5
85	2x41	I1x51	beta_off	21.4286	0	No	No	No	No	5	7
86	1x56	8x53	beta_off	0	0	No	No	No	No	7	7
87	1x28	1x30	beta_off	28.5714	0	No	No	No	No	0	2
88	5x68	6x27	beta_off	50	0	No	No	No	No	7	0
89	5x58	6x38	beta_off	14.2857	0	Yes	Yes	No	No	9	5
90	1x42	7x43	beta_off	28.5714	0	No	No	No	No	6	4
91	4x40	4x43	beta_off	28.5714	0	No	No	No	No	5	4
92	6x41	6x42	beta_off	0	0	Yes	No	No	No	8	5
93	1x36	2x65	beta_off	0	0	No	No	No	No	5	5
94	5x72	6x24	beta_off	25	0	No	No	No	No	0	0
95	4x56	4x57	beta_off	0	0	No	No	No	No	5	7
96	8x48	8x52	beta_off	0	0	No	No	No	No	6	4
97	6x24	6x28	beta_off	25	0	No	No	No	No	0	0
98	1x27	1x31	beta_off	7.14286	0	No	No	No	Yes	0	3
99	1x33	1x37	beta_off	0	0	No	No	No	No	5	4
100	8x55	8x60	beta_off	25	0	No	No	No	No	4	7
101	5x66	5x70	beta_off	25	0	No	No	No	No	5	0
102	7x33	7x36	beta_off	0	0	No	No	No	No	4	5
103	1x30	1x33	beta_off	0	0	No	No	No	No	2	5
104	1x38	1x41	beta_off	0	0	No	No	No	No	5	4
105	5x67	5x71	beta_off	0	0	No	No	No	No	4	0
106	1x38	1x42	beta_off	0	0	No	No	No	No	5	6
107	1x29	1x33	beta_off	0	0	No	No	No	No	0	5
108	6x25	I3	beta_off	0	0	No	No	No	Yes	0	0
109	7x48	7x51	beta_off	0	0	No	No	No	No	6	6
110	1x31	1x35	Shared	100	33.3333	No	Yes	No	No	3	4
111	1x39	7x39	Shared	100	100	No	No	Yes	Yes	6	6
112	1x46	2x54	Shared	100	100	No	No	No	No	7	7
113	1x46	7x46	Shared	100	100	No	No	No	No	7	9
114	1x47	2x55	Shared	100	16.6667	No	No	No	No	6	5
115	1x49	7x50	Shared	100	58.3333	No	No	No	No	8	9
116	1x50	2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
117	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
118	1x51	2x51	Shared	100	41.6667	No	No	No	No	3	7
119	1x52	8x54	Shared	100	100	No	No	No	No	6	7
120	1x52	8x58	Shared	100	50	No	No	No	No	6	6
121	1x57	2x40	Shared	100	100	No	No	No	Yes	7	9
122	1x57	2x44	Shared	100	100	No	No	No	No	7	5
123	1x57	8x50	Shared	100	100	No	No	Yes	Yes	7	8
124	1x60	I1x50	Shared	100	100	Yes	Yes	No	No	6	8
125	8x49	I1x49	Shared	100	100	No	No	No	No	6	5
126	8x50	I1x50	Shared	100	100	Yes	Yes	No	No	8	8
127	2x37	2x40	Shared	100	100	No	No	No	Yes	7	9
128	2x40	8x50	Shared	100	100	No	Yes	Yes	Yes	9	8
129	2x41	4x39	Shared	100	100	No	No	No	No	5	3
130	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	5
131	2x42	3x49	Shared	100	100	Yes	Yes	Yes	No	8	9
132	2x42	4x46	Shared	100	100	Yes	Yes	No	Yes	8	7
133	2x45	3x42	Shared	100	100	No	No	No	No	9	8
134	2x45	4x46	Shared	100	100	No	No	No	Yes	9	7
135	2x45	4x50	Shared	100	100	No	No	Yes	No	9	9
136	2x46	3x43	Shared	100	100	No	Yes	No	No	9	8
137	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
138	2x50	7x49	Shared	100	100	No	Yes	No	Yes	9	9
139	2x51	2x55	Shared	100	33.3333	No	No	No	No	7	5
140	2x53	3x35	Shared	100	100	No	No	No	No	8	6
141	2x53	7x46	Shared	100	100	No	No	No	No	8	9
142	2x56	3x32	Shared	100	100	No	No	No	No	7	7
143	2x56	7x42	Shared	100	100	No	No	Yes	Yes	7	7
144	2x57	7x42	Shared	100	83.3333	No	No	Yes	Yes	7	7
145	2x59	E1x52	Shared	100	100	Yes	No	Yes	Yes	4	5
146	2x59	3x28	Shared	100	100	Yes	No	No	Yes	4	6
147	2x60	3x28	Shared	100	100	No	No	No	Yes	6	6
148	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	5	7
149	2x64	7x39	Shared	100	50	No	No	Yes	Yes	5	6
150	2x66	E1x51	Shared	100	33.3333	No	No	No	No	4	4
151	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	7	5
152	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	7
153	3x28	E1x50	Shared	100	100	No	Yes	Yes	Yes	6	7
154	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	7	9
155	E1x51	E1x52	Shared	100	100	No	No	Yes	Yes	4	5
156	3x22	E2	Shared	100	100	No	No	Yes	Yes	4	3
157	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
158	3x26	E2	Shared	100	100	No	No	Yes	Yes	6	3
159	3x27	4x58	Shared	100	66.6667	Yes	No	No	Yes	4	5
160	3x30	4x58	Shared	100	100	No	No	No	Yes	6	5
161	3x30	4x61	Shared	100	100	No	No	No	No	6	6
162	3x30	4x62	Shared	100	33.3333	No	No	No	No	6	4
163	3x32	7x42	Shared	100	100	No	No	Yes	Yes	7	7
164	3x32	Lig	Shared	100	100	No	No	Yes	Yes	7	0
165	3x33	4x57	Shared	100	100	No	No	No	No	6	7
166	3x33	Lig	Shared	100	100	No	No	Yes	Yes	6	0
167	3x36	6x48	Shared	100	100	No	No	Yes	Yes	6	8
168	3x36	Lig	Shared	100	100	No	No	Yes	Yes	6	0
169	3x37	4x53	Shared	100	100	No	No	No	No	6	8
170	3x37	5x461	Shared	100	100	No	No	No	No	6	6
171	3x38	4x50	Shared	100	100	No	No	Yes	No	7	9
172	3x40	5x50	Shared	100	100	No	No	No	Yes	8	9
173	3x40	6x44	Shared	100	100	No	No	Yes	Yes	8	9
174	3x41	4x49	Shared	100	100	Yes	No	No	No	6	6
175	3x41	4x52	Shared	100	33.3333	Yes	No	No	No	6	4
176	3x49	I2x53	Shared	100	100	Yes	No	Yes	Yes	9	7
177	3x51	3x55	Shared	100	100	No	Yes	No	No	8	7
178	3x51	5x60	Shared	100	100	No	Yes	No	Yes	8	5
179	3x53	I2x53	Shared	100	100	No	No	Yes	Yes	8	7
180	3x54	5x64	Shared	100	25	No	No	No	No	9	6
181	I2x53	I2x57	Shared	100	100	Yes	Yes	No	No	7	6
182	4x38	4x41	Shared	100	100	No	No	No	No	8	7
183	4x61	E2	Shared	100	100	No	No	Yes	Yes	6	3
184	4x63	E2	Shared	100	100	No	No	Yes	Yes	5	3
185	4x64	E2	Shared	100	100	No	No	Yes	Yes	5	3
186	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
187	E2	E2x52	Shared	100	100	Yes	Yes	Yes	No	3	4
188	5x39	E2	Shared	100	100	Yes	Yes	Yes	Yes	7	3
189	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	5
190	E2x52	Lig	Shared	100	100	Yes	No	Yes	Yes	4	0
191	5x37	6x59	Shared	100	50	No	No	Yes	No	5	5
192	5x39	5x43	Shared	100	100	Yes	Yes	No	No	7	6
193	5x43	Lig	Shared	100	100	No	No	Yes	Yes	6	0
194	5x461	Lig	Shared	100	100	No	No	Yes	Yes	6	0
195	5x47	5x48	Shared	100	100	Yes	Yes	No	No	7	5
196	5x47	5x51	Shared	100	100	Yes	Yes	No	No	7	6
197	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	7	7
198	5x48	6x56	Shared	100	100	No	No	No	No	5	5
199	5x49	5x50	Shared	100	33.3333	No	No	No	Yes	5	9
200	5x51	5x55	Shared	100	50	No	No	No	No	6	5
201	5x56	5x60	Shared	100	41.6667	No	No	No	Yes	5	5
202	5x58	6x41	Shared	100	100	Yes	Yes	Yes	No	9	8
203	5x62	5x66	Shared	100	100	No	Yes	No	No	6	5
204	5x64	5x67	Shared	100	100	No	No	No	No	6	4
205	6x36	7x55	Shared	100	33.3333	No	No	No	Yes	8	7
206	6x39	7x52	Shared	100	33.3333	No	No	No	No	7	8
207	6x39	7x55	Shared	100	33.3333	No	No	No	Yes	7	7
208	6x47	7x45	Shared	100	100	No	No	No	No	8	9
209	6x48	6x51	Shared	100	100	Yes	Yes	Yes	Yes	8	7
210	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
211	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	6
212	6x49	6x53	Shared	100	100	No	Yes	No	No	7	6
213	6x50	7x37	Shared	100	100	No	No	No	Yes	9	5
214	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	7	7
215	6x51	7x34	Shared	100	100	Yes	Yes	No	Yes	7	4
216	6x51	7x38	Shared	100	100	Yes	Yes	No	No	7	6
217	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
218	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
219	6x54	E3	Shared	100	100	No	No	Yes	Yes	4	4
220	6x55	7x34	Shared	100	100	No	No	No	Yes	6	4
221	6x61	E3	Shared	100	100	No	No	Yes	Yes	4	4
222	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	4	4
223	7x30	7x32	Shared	100	100	No	No	No	No	5	3
224	7x33	7x37	Shared	100	100	No	No	No	Yes	4	5
225	7x38	7x42	Shared	100	100	No	No	Yes	Yes	6	7
226	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
227	7x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
228	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
229	8x47	8x48	Shared	100	100	No	No	No	No	8	6
230	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	8
231	8x50	8x54	Shared	100	100	Yes	Yes	No	No	8	7
232	5x60	5x63	Shared	100	16.6667	No	Yes	No	No	5	4
233	6x58	E3	Shared	100	100	No	No	Yes	Yes	4	4
234	3x41	5x50	Shared	100	100	Yes	No	No	Yes	6	9
235	5x36	5x39	Shared	57.1429	100	No	No	Yes	Yes	5	7
236	6x54	7x34	Shared	57.1429	100	No	No	No	Yes	4	4
237	2x52	3x35	Shared	57.1429	100	No	No	No	No	6	6
238	1x32	2x65	Shared	57.1429	33.3333	No	No	No	No	5	5
239	2x46	3x42	Shared	57.1429	100	No	Yes	No	No	9	8
240	1x50	2x47	Shared	28.5714	33.3333	Yes	Yes	No	No	9	8
241	3x44	5x53	Shared	32.1429	100	No	No	No	No	6	6
242	1x54	2x47	Shared	32.1429	50	No	No	No	No	7	8
243	5x44	6x52	Shared	50	100	No	No	Yes	Yes	6	7
244	1x43	2x58	Shared	75	100	No	No	No	No	5	9
245	4x60	5x39	Shared	50	100	No	No	Yes	Yes	7	7
246	2x42	4x42	Shared	50	8.33333	Yes	Yes	No	No	8	7
247	1x46	7x47	Shared	32.1429	33.3333	No	No	No	No	7	6
248	6x57	E3	Shared	39.2857	33.3333	No	No	Yes	Yes	5	4
249	6x43	7x48	Shared	57.1429	50	No	No	No	No	6	6
250	5x47	6x49	Shared	32.1429	100	Yes	Yes	No	Yes	7	7
251	8x51	8x55	Shared	50	50	No	No	No	No	8	4
252	7x43	7x48	Shared	50	16.6667	No	No	No	No	4	6
253	3x21	E1x50	Shared	0	33.3333	No	No	Yes	Yes	7	7
254	3x48	3x52	Shared	0	16.6667	No	No	No	No	6	5
255	I1x48	I1x51	Shared	50	100	No	No	No	No	6	7
256	3x56	I2x50	Shared	14.2857	0	Yes	No	No	No	6	8
257	1x60	8x53	Shared	50	100	Yes	Yes	No	No	6	7
258	2x49	4x50	Shared	0	33.3333	No	No	Yes	No	8	9
259	2x551	3x31	Shared	50	50	No	No	No	No	4	5
260	1x60	8x56	Shared	50	100	Yes	Yes	No	No	6	4
261	4x56	5x46	Shared	50	50	No	No	No	No	5	4
262	3x55	3x56	Shared	50	16.6667	No	No	Yes	No	7	6
263	1x55	8x57	Shared	50	25	No	No	No	No	4	6
264	1x35	1x39	Shared	0	33.3333	No	No	No	No	4	6
265	1x48	1x49	Shared	0	8.33333	No	No	No	No	4	8
266	5x36	5x38	Shared	0	100	No	No	No	No	5	4
267	1x50	2x51	Shared	0	41.6667	Yes	Yes	No	No	9	7
268	4x48	4x52	Shared	0	8.33333	No	No	No	No	3	4
269	1x35	2x65	Shared	0	33.3333	No	No	No	No	4	5
270	3x34	4x54	Shared	7.14286	0	No	No	No	No	5	3
271	1x59	1x60	Shared	7.14286	33.3333	No	No	Yes	Yes	5	6
272	4x59	4x60	Shared	7.14286	100	No	No	No	No	6	7
273	1x54	2x48	Shared	0	41.6667	No	No	No	No	7	5
274	5x40	6x59	Shared	0	33.3333	No	No	Yes	No	6	5
275	4x55	4x59	Shared	14.2857	25	No	No	No	No	4	6
276	4x38	4x40	Shared	0	33.3333	No	No	No	No	8	5
277	4x44	4x48	Shared	0	0	No	No	No	No	3	3
278	1x45	7x47	Shared	0	16.6667	No	No	No	No	5	6
279	1x44	1x48	Shared	7.14286	33.3333	No	No	No	No	5	4
280	5x55	5x59	Shared	0	0	No	No	No	No	5	2
281	1x37	1x41	Shared	0	8.33333	No	No	No	No	4	4
282	1x58	1x59	Shared	0	0	No	No	No	No	2	5
283	2x67	E1x49	Shared	0	0	No	No	No	No	4	3
284	4x47	4x51	Shared	7.14286	8.33333	No	No	No	No	4	4
285	1x34	1x37	Shared	0	0	No	No	No	No	4	4
286	4x51	4x55	Shared	0	0	No	No	No	No	4	4
287	6x46	6x47	Shared	0	0	No	No	No	No	5	8
288	1x53	2x47	beta_on	0	100	No	No	No	No	9	8
289	1x53	7x54	beta_on	0	100	No	No	No	No	9	6
290	2x40	I1x50	beta_on	0	100	No	Yes	No	No	9	8
291	2x39	3x49	beta_on	0	100	No	No	Yes	No	8	9
292	2x46	2x50	beta_on	0	100	No	Yes	No	Yes	9	9
293	2x46	7x49	beta_on	0	100	No	Yes	No	Yes	9	9
294	2x50	3x39	beta_on	0	100	No	Yes	No	No	9	9
295	2x57	2x58	beta_on	0	100	No	No	No	No	7	9
296	2x61	7x39	beta_on	0	100	No	No	Yes	Yes	6	6
297	3x24	E1x52	beta_on	0	100	No	No	Yes	Yes	4	5
298	3x28	Lig	beta_on	0	100	No	Yes	Yes	Yes	6	0
299	3x34	4x57	beta_on	0	100	No	No	No	No	5	7
300	3x34	4x58	beta_on	0	100	No	No	No	Yes	5	5
301	3x38	4x53	beta_on	0	100	No	No	No	No	7	8
302	3x40	6x48	beta_on	0	100	No	No	Yes	Yes	8	8
303	3x43	7x49	beta_on	0	100	No	No	No	Yes	8	9
304	3x43	7x53	beta_on	0	100	No	No	Yes	Yes	8	9
305	3x46	7x53	beta_on	0	100	No	No	Yes	Yes	9	9
306	3x47	5x58	beta_on	0	100	No	No	Yes	Yes	8	9
307	3x50	5x58	beta_on	0	100	Yes	No	Yes	Yes	9	9
308	3x50	7x53	beta_on	0	100	Yes	No	Yes	Yes	9	9
309	3x51	5x57	beta_on	0	100	No	Yes	No	No	8	6
310	3x55	5x60	beta_on	0	100	No	No	No	Yes	7	5
311	3x56	I2x52	beta_on	0	100	Yes	No	No	No	6	5
312	4x57	4x58	beta_on	0	100	No	No	No	Yes	7	5
313	4x61	5x39	beta_on	0	100	No	No	Yes	Yes	6	7
314	5x36	E2	beta_on	0	100	No	No	Yes	Yes	5	3
315	E2	E3	beta_on	0	100	Yes	Yes	Yes	Yes	3	4
316	5x37	6x60	beta_on	0	100	No	No	No	No	5	5
317	5x44	6x55	beta_on	0	100	No	No	No	No	6	6
318	5x44	6x56	beta_on	0	100	No	No	No	No	6	5
319	5x47	6x44	beta_on	0	100	Yes	Yes	Yes	Yes	7	9
320	5x51	6x44	beta_on	0	100	No	No	Yes	Yes	6	9
321	5x54	5x58	beta_on	0	100	No	No	Yes	Yes	8	9
322	5x54	6x44	beta_on	0	100	No	No	Yes	Yes	8	9
323	5x58	6x37	beta_on	0	100	Yes	Yes	No	No	9	8
324	5x58	6x40	beta_on	0	100	Yes	Yes	No	No	9	8
325	5x62	6x34	beta_on	0	100	No	Yes	No	No	6	7
326	5x62	6x37	beta_on	0	100	No	Yes	No	No	6	8
327	5x66	6x30	beta_on	0	100	No	No	No	No	5	7
328	I3	I3	beta_on	0	100	No	Yes	No	Yes	0	0
329	6x43	7x52	beta_on	0	100	No	No	No	No	6	8
330	6x45	6x49	beta_on	0	100	No	No	No	Yes	5	7
331	6x48	7x45	beta_on	0	100	Yes	Yes	No	No	8	9
332	6x49	6x50	beta_on	0	100	No	Yes	No	No	7	9
333	6x51	7x37	beta_on	0	100	Yes	Yes	No	Yes	7	5
334	6x58	7x34	beta_on	0	100	No	No	No	Yes	4	4
335	7x30	7x33	beta_on	0	100	No	No	No	No	5	4
336	7x45	7x49	beta_on	0	100	No	No	No	Yes	9	9
337	7x52	7x53	beta_on	0	100	No	No	Yes	Yes	8	9
338	7x54	8x50	beta_on	0	100	No	No	Yes	Yes	6	8
339	6x51	6x55	beta_on	0	100	Yes	Yes	No	No	7	6
340	1x42	7x39	beta_on	0	100	No	No	Yes	Yes	6	6
341	4x39	4x43	beta_on	0	100	No	No	No	No	3	4
342	E1x49	E2	beta_on	0	100	No	No	Yes	Yes	3	3
343	6x31	6x35	beta_on	0	100	Yes	No	No	No	5	7
344	3x51	3x52	beta_on	0	50	No	Yes	No	No	8	5
345	5x69	6x29	beta_on	0	66.6667	No	No	No	No	5	6
346	3x54	5x61	beta_on	0	66.6667	No	No	No	No	9	9
347	3x37	4x56	beta_on	0	50	No	No	No	No	6	5
348	1x56	8x54	beta_on	0	25	No	No	No	No	7	7
349	1x60	I1x49	beta_on	0	50	Yes	Yes	No	No	6	5
350	2x40	2x43	beta_on	0	50	No	Yes	No	No	9	7
351	5x69	6x30	beta_on	0	41.6667	No	No	No	No	5	7
352	7x55	8x51	beta_on	0	50	No	Yes	No	No	7	8
353	5x74	5x75	beta_on	0	33.3333	No	No	No	No	0	0
354	2x38	I2x57	beta_on	0	33.3333	No	No	No	No	6	6
355	5x73	I3	beta_on	0	66.6667	No	No	No	Yes	0	0
356	5x75	I3	beta_on	0	33.3333	No	No	No	Yes	0	0
357	7x35	Lig	beta_on	0	66.6667	No	No	Yes	Yes	4	0
358	3x44	5x50	beta_on	0	50	No	No	No	Yes	6	9
359	6x31	6x34	beta_on	0	41.6667	Yes	No	No	No	5	7
360	7x31	7x32	beta_on	0	50	No	No	No	No	3	3
361	I2x52	I2x56	beta_on	0	66.6667	No	No	No	No	5	5
362	2x52	3x31	beta_on	0	33.3333	No	No	No	No	6	5
363	2x42	4x45	beta_on	0	8.33333	Yes	Yes	No	No	8	6
364	I2x53	I2x54	beta_on	0	50	Yes	Yes	No	No	7	5
365	5x40	E2	beta_on	0	33.3333	No	No	Yes	Yes	6	3
366	5x57	5x58	beta_on	0	33.3333	No	No	Yes	Yes	6	9
367	8x56	8x57	beta_on	0	33.3333	No	No	No	No	4	6
368	5x60	5x64	beta_on	0	50	No	Yes	No	No	5	6
369	5x37	5x41	beta_on	0	8.33333	No	No	No	No	5	5
370	5x68	5x71	beta_on	0	41.6667	No	No	No	No	7	0
371	3x28	3x29	beta_on	0	8.33333	No	Yes	No	No	6	6
372	2x41	4x46	beta_on	0	8.33333	No	No	No	Yes	5	7
373	5x67	5x70	beta_on	0	33.3333	No	No	No	No	4	0
374	5x45	5x49	beta_on	0	0	No	No	No	No	4	5
375	7x36	7x37	beta_on	0	33.3333	No	No	No	Yes	5	5
376	7x36	7x40	beta_on	0	33.3333	No	No	No	No	5	7
377	5x72	6x29	beta_on	0	33.3333	No	No	No	No	0	6
378	2x62	E1x51	beta_on	0	33.3333	No	No	No	No	4	4
379	5x69	5x73	beta_on	0	33.3333	No	No	No	No	5	0
380	5x72	5x76	beta_on	0	8.33333	No	No	No	No	0	0
381	1x38	7x39	beta_on	0	33.3333	No	No	Yes	Yes	5	6
382	1x29	1x31	beta_on	0	33.3333	No	No	No	Yes	0	3
383	1x60	I1x48	beta_on	0	33.3333	Yes	Yes	No	No	6	6
384	8x52	8x56	beta_on	0	16.6667	No	No	No	No	4	4
385	5x70	5x71	beta_on	0	16.6667	No	No	No	No	0	0
386	2x38	4x38	beta_on	0	16.6667	No	No	No	No	6	8
387	5x65	6x33	beta_on	0	0	No	No	No	No	8	8
388	6x27	6x30	beta_on	0	8.33333	No	No	No	No	0	7
389	6x32	6x35	beta_on	0	25	No	No	No	No	8	7
390	1x36	1x39	beta_on	0	0	No	No	No	No	5	6
391	6x28	6x29	beta_on	0	8.33333	No	No	No	No	0	6
392	5x62	6x33	beta_on	0	8.33333	No	Yes	No	No	6	8
393	7x51	7x55	beta_on	0	0	No	No	No	Yes	6	7
394	I2x55	I2x56	beta_on	0	8.33333	No	No	No	No	5	5
395	6x42	6x45	beta_on	0	0	No	No	No	No	5	5
396	1x31	1x34	beta_on	0	0	No	Yes	No	No	3	4
397	3x22	3x23	beta_on	0	8.33333	No	No	No	No	4	2
398	1x30	1x31	beta_on	0	8.33333	No	No	No	Yes	2	3
399	1x40	1x43	beta_on	0	8.33333	No	No	No	No	4	5
400	4x46	4x47	beta_on	0	8.33333	No	Yes	No	No	7	4
401	6x38	6x42	beta_on	0	0	No	No	No	No	5	5
402	1x32	1x33	beta_on	0	0	No	No	No	No	5	5
403	8x58	8x59	beta_on	0	0	No	No	No	No	6	3
404	I2x51	I2x52	beta_on	0	0	No	No	No	No	6	5

Orange: nodes, hubs and links specific of beta_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	beta_off Avg Int. Strength	beta_on Avg Int. Strength	beta_off Num Of Links	beta_on Num Of Links	ConSurf
1	2x59	beta_off	0	0	4	2	4
2	3x27	beta_off	0	0	4	1	4
3	3x41	beta_off	50	0	4	3	6
4	3x49	beta_off	67.8571	33.3333	4	3	9
5	3x50	beta_off	50	8.33333	4	2	9
6	3x56	beta_off	0	0	4	3	6
7	4x50	beta_off	0	16.6667	4	3	9
8	E2x52	beta_off	50	16.6667	4	2	4
9	6x31	beta_off	28.5714	0	4	2	5
10	6x41	beta_off	0	0	5	1	8
11	6x59	beta_off	0	0	4	2	5
12	1x50	Shared	0	0	4	4	9
13	1x60	Shared	0	25	4	6	6
14	2x42	Shared	92.8571	16.6667	5	5	8
15	E1x50	Shared	100	100	7	6	7
16	E1x52	Shared	85.7143	0	4	4	5
17	I2x53	Shared	50	8.33333	6	4	7
18	E2	Shared	100	100	10	14	3
19	5x39	Shared	50	75	5	5	7
20	5x47	Shared	0	100	4	5	7
21	5x58	Shared	50	100	4	7	9
22	6x44	Shared	100	91.6667	5	4	9
23	6x48	Shared	92.8571	100	6	6	8
24	6x51	Shared	92.8571	91.6667	5	7	7
25	6x52	Shared	92.8571	100	5	5	7
26	E3	Shared	85.7143	66.6667	7	7	4
27	7x39	Shared	25	0	4	6	6
28	7x42	Shared	100	100	6	6	7
29	7x53	Shared	100	58.3333	5	4	9
30	8x50	Shared	100	100	6	6	8
31	Lig	Shared	100	100	12	12	0
32	1x31	beta_on	0	0	2	4	3
33	2x40	beta_on	0	66.6667	3	5	9
34	2x46	beta_on	0	58.3333	2	4	9
35	2x50	beta_on	0	83.3333	3	5	9
36	3x28	beta_on	0	33.3333	3	5	6
37	3x51	beta_on	0	25	2	4	8
38	4x46	beta_on	0	0	2	4	7
39	4x58	beta_on	0	33.3333	3	4	5
40	5x50	beta_on	0	8.33333	3	4	9
41	5x60	beta_on	0	0	3	5	5
42	5x62	beta_on	0	0	2	4	6
43	I3	beta_on	0	8.33333	1	4	0
44	6x49	beta_on	0	16.6667	2	4	7
45	7x34	beta_on	0	16.6667	3	4	4
46	7x37	beta_on	0	0	3	4	5
47	7x49	beta_on	0	66.6667	3	4	9
48	7x55	beta_on	0	0	3	4	7

Orange: nodes, hubs and links specific of beta_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	beta_off Recurrence	beta_on Recurrence	beta_off Hub1?	beta_on Hub1?	beta_off Hub2?	beta_on Hub2?	ConSurf1	ConSurf2
1	2x56	7x42	beta_off	54.1199	2.00705	No	No	Yes	Yes	7	7
2	2x53	2x56	beta_off	100	0	No	No	No	No	8	7
3	7x49	7x53	beta_off	51.4429	0	No	Yes	Yes	Yes	9	9
4	7x53	8x50	beta_off	47.6142	0	Yes	Yes	Yes	Yes	9	8
5	6x48	Lig	beta_off	71.9029	0	Yes	Yes	Yes	Yes	8	0
6	6x44	6x48	beta_off	82.3922	0	Yes	Yes	Yes	Yes	9	8
7	3x43	6x44	beta_off	70.9163	0	No	No	Yes	Yes	8	9
8	3x49	I2x53	beta_off	38.9366	8.83509	Yes	No	Yes	Yes	9	7
9	I2x53	I2x57	beta_off	10.3041	5.57877	Yes	Yes	No	No	7	6
10	2x42	3x46	beta_off	20.497	0	Yes	Yes	No	No	8	9
11	3x26	E2	beta_off	23.2582	1.62202	No	No	Yes	Yes	6	3
12	3x26	4x62	beta_off	22.5107	0	No	No	No	No	6	4
13	4x58	4x62	beta_off	21.6857	0	No	Yes	No	No	5	4
14	3x27	4x58	beta_off	41.1927	1.65888	Yes	No	No	Yes	4	5
15	3x24	3x27	beta_off	32.67	0	No	No	Yes	No	4	4
16	2x59	3x24	beta_off	30.5149	0	Yes	No	No	No	4	4
17	4x61	E2	beta_off	23.2919	5.22241	No	No	Yes	Yes	6	3
18	3x30	4x61	beta_off	22.477	7.58581	No	No	No	No	6	6
19	3x30	4x58	beta_off	21.6217	4.07143	No	No	No	Yes	6	5
20	2x59	E1x50	beta_off	11.0045	0	Yes	No	Yes	Yes	4	7
21	2x59	E1x52	beta_off	13.2438	8.80233	Yes	No	Yes	Yes	4	5
22	I2x52	I2x53	beta_off	17.8132	0	No	No	Yes	Yes	5	7
23	5x68	I2x52	beta_off	16.702	0	No	No	No	No	7	5
24	3x54	5x68	beta_off	14.9106	0	No	No	No	No	9	7
25	3x54	5x64	beta_off	13.7926	2.96961	No	No	No	No	9	6
26	3x55	5x64	beta_off	10.6004	0	No	No	No	No	7	6
27	6x51	7x34	beta_off	24.9554	8.95797	Yes	Yes	No	Yes	7	4
28	6x54	7x34	beta_off	36.4246	4.08782	No	No	No	Yes	4	4
29	6x54	E3	beta_off	21.5241	3.01057	No	No	Yes	Yes	4	4
30	5x37	E3	beta_off	12.8633	0	No	No	Yes	Yes	5	4
31	6x55	Lig	beta_off	14.0856	0	No	No	Yes	Yes	6	0
32	6x55	7x34	beta_off	13.2236	0.299009	No	No	No	Yes	6	4
33	5x37	6x59	beta_off	11.0078	5.39035	No	No	Yes	No	5	5
34	3x46	6x41	beta_off	18.5776	0	No	No	Yes	No	9	8
35	6x40	7x49	beta_off	13.7825	0	No	No	No	Yes	8	9
36	6x40	7x52	beta_off	12.6713	0	No	No	No	No	8	8
37	6x44	7x45	beta_off	19.0356	0	Yes	Yes	No	No	9	9
38	6x54	7x37	beta_off	13.1865	0	No	No	No	Yes	4	5
39	8x47	8x50	beta_off	10.9944	4.4114	No	No	Yes	Yes	8	8
40	6x43	7x45	beta_off	14.6311	0	No	No	No	No	6	9
41	4x60	5x39	beta_off	11.2099	6.83215	No	No	Yes	Yes	7	7
42	6x43	7x48	beta_off	13.5131	4.4196	No	No	No	No	6	6
43	7x43	7x48	beta_off	11.257	2.21185	No	No	No	No	4	6
44	1x42	7x43	beta_off	10.1189	0	No	No	No	No	6	4
45	2x56	3x32	beta_off	47.3785	1.71213	No	No	No	No	7	7
46	3x32	Lig	beta_off	47.9678	3.2891	No	No	Yes	Yes	7	0
47	7x39	7x42	Shared	10.9674	35.2667	Yes	Yes	Yes	Yes	6	7
48	2x53	7x46	Shared	95.4541	10.9732	No	No	No	No	8	9
49	2x50	7x46	Shared	87.7429	21.7457	No	Yes	No	No	9	9
50	1x50	2x50	Shared	22.4231	81.6622	Yes	Yes	No	Yes	9	9
51	2x50	7x49	Shared	66.9057	84.1935	No	Yes	No	Yes	9	9
52	8x50	8x54	Shared	12.8599	10.5472	Yes	Yes	No	No	8	7
53	8x50	I1x50	Shared	16.5808	27.9512	Yes	Yes	No	No	8	8
54	1x60	I1x50	Shared	11.0045	26.0957	Yes	Yes	No	No	6	8
55	7x42	Lig	Shared	58.2315	38.1052	Yes	Yes	Yes	Yes	7	0
56	2x46	3x43	Shared	70.2428	19.6158	No	Yes	No	No	9	8
57	2x46	3x42	Shared	69.5626	18.9727	No	Yes	No	No	9	8
58	2x45	3x42	Shared	68.8756	17.3507	No	No	No	No	9	8
59	2x45	4x46	Shared	64.6126	18.6409	No	No	No	Yes	9	7
60	2x42	4x46	Shared	63.8785	15.0406	Yes	Yes	No	Yes	8	7
61	2x42	3x49	Shared	45.1561	10.8667	Yes	Yes	Yes	No	8	9
62	E2x52	Lig	Shared	59.3259	31.6581	Yes	No	Yes	Yes	4	0
63	E2	E2x52	Shared	49.84	30.3637	Yes	Yes	Yes	No	3	4
64	6x51	Lig	Shared	13.9172	34.2508	Yes	Yes	Yes	Yes	7	0
65	5x47	6x52	Shared	10.725	29.7534	Yes	Yes	Yes	Yes	7	7
66	6x39	7x52	Shared	10.8058	12.8205	No	No	No	No	7	8
67	1x39	7x39	beta_on	7.96713	25.256	No	No	Yes	Yes	6	6
68	6x51	7x38	beta_on	5.25979	10.0475	Yes	Yes	No	No	7	6
69	6x48	6x51	beta_on	7.14887	49.4225	Yes	Yes	Yes	Yes	8	7
70	6x48	7x45	beta_on	0	100	Yes	Yes	No	No	8	9
71	7x45	7x49	beta_on	0	96.9526	No	No	No	Yes	9	9
72	3x36	Lig	beta_on	0.905815	30.1016	No	No	Yes	Yes	6	0
73	3x36	6x48	beta_on	0.461326	30.4252	No	No	Yes	Yes	6	8
74	6x52	Lig	beta_on	8.25673	52.0726	Yes	Yes	Yes	Yes	7	0
75	6x48	6x52	beta_on	4.03408	34.3246	Yes	Yes	Yes	Yes	8	7
76	1x50	2x47	beta_on	5.69418	64.336	Yes	Yes	No	No	9	8
77	1x53	2x47	beta_on	0	58.4132	No	No	No	No	9	8
78	1x53	7x54	beta_on	0	56.4225	No	No	No	No	9	6
79	7x54	8x50	beta_on	0	54.4237	No	No	Yes	Yes	6	8
80	5x461	Lig	beta_on	7.66071	13.0827	No	No	Yes	Yes	6	0
81	3x37	5x461	beta_on	6.4855	11.6204	No	No	No	No	6	6
82	3x43	7x49	beta_on	0	30.4579	No	No	No	Yes	8	9
83	3x28	Lig	beta_on	0	32.5715	No	Yes	Yes	Yes	6	0
84	2x59	3x28	beta_on	4.44153	10.5349	Yes	No	No	Yes	4	6
85	3x28	E1x50	beta_on	0.0673469	17.4121	No	Yes	Yes	Yes	6	7
86	E1x51	E1x52	beta_on	8.95377	10.6128	No	No	Yes	Yes	4	5
87	3x33	Lig	beta_on	4.85571	12.7509	No	No	Yes	Yes	6	0
88	3x33	4x57	beta_on	3.67377	11.1944	No	No	No	No	6	7
89	5x43	Lig	beta_on	9.06152	14.4466	No	No	Yes	Yes	6	0
90	5x39	5x43	beta_on	8.41499	13.1605	Yes	Yes	No	No	7	6
91	3x40	6x48	beta_on	0	25.1864	No	No	Yes	Yes	8	8
92	3x40	5x50	beta_on	4.88265	20.0254	No	No	No	Yes	8	9
93	5x47	6x44	beta_on	0	25.5304	Yes	Yes	Yes	Yes	7	9
94	3x41	5x50	beta_on	2.64673	10.1131	Yes	No	No	Yes	6	9
95	3x43	7x53	beta_on	0	48.3411	No	No	Yes	Yes	8	9
96	5x54	6x44	beta_on	0	33.2309	No	No	Yes	Yes	8	9
97	5x54	5x58	beta_on	0	33.0794	No	No	Yes	Yes	8	9
98	5x57	5x58	beta_on	0	29.6715	No	No	Yes	Yes	6	9
99	3x51	5x57	beta_on	0	28.3403	No	Yes	No	No	8	6
100	3x51	3x55	beta_on	4.77826	10.0025	No	Yes	No	No	8	7
101	3x51	5x60	beta_on	3.59296	14.291	No	Yes	No	Yes	8	5
102	5x58	6x37	beta_on	0	27.1688	Yes	Yes	No	No	9	8
103	5x62	6x37	beta_on	0	25.7885	No	Yes	No	No	6	8
104	5x62	5x66	beta_on	4.13847	16.4209	No	Yes	No	No	6	5
105	5x60	5x64	beta_on	0	10.2851	No	Yes	No	No	5	6
106	7x52	7x53	beta_on	0	21.4426	No	No	Yes	Yes	8	9
107	6x51	7x37	beta_on	0	11.0224	Yes	Yes	No	Yes	7	5
108	5x66	6x30	beta_on	0	15.0078	No	No	No	No	5	7
109	5x69	6x30	beta_on	0	12.3781	No	No	No	No	5	7
110	6x39	7x55	beta_on	8.93019	10.9855	No	No	No	Yes	7	7
111	1x35	1x39	beta_on	6.19254	21.1887	No	No	No	No	4	6
112	1x31	1x35	beta_on	2.02041	12.7673	No	Yes	No	No	3	4
113	3x50	5x58	beta_on	0	29.5855	Yes	No	Yes	Yes	9	9
114	2x46	2x50	beta_on	0	19.5339	No	Yes	No	Yes	9	9
115	3x50	7x53	beta_on	0	29.5445	Yes	No	Yes	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	6.72643	9.00583	1	1	2	1
2x56	7x42	Shared	4.825	4.735	1	1	2	1
2x57	7x42	Shared	3.56179	3.2625	0	0	2	1
2x59	E1x50	beta_off	3.755	0	3	0	2	2
2x59	3x28	Shared	5.69179	8.53083	3	0	2	1
2x60	3x28	Shared	4.27107	3.635	0	0	2	1
3x28	E1x50	Shared	11.7161	10.7783	3	0	1	2
3x29	E2x52	beta_off	6.11536	0	0	0	2	1
3x32	7x42	Shared	9.84929	10.2475	1	1	1	1
3x32	Lig	Shared	18.755	15.7	1	1	1	0
3x33	4x57	Shared	5.82679	4.84583	0	0	1	2
3x33	Lig	Shared	9.71714	8.60917	0	0	1	0
3x36	6x48	Shared	9.67786	8.88917	1	0	1	1
3x36	Lig	Shared	4.91536	7.00333	1	0	1	0
3x37	4x57	beta_off	4.56893	0	0	0	2	2
3x37	5x461	Shared	8.45036	8.525	0	0	2	1
3x40	6x44	Shared	7.2225	5.02167	0	0	2	2
E2	E2	Shared	114.499	66.4617	1	1	2	2
E2	E2x52	Shared	14.78	7.49	1	1	2	1
5x39	E2	Shared	11.8896	8.71917	1	1	2	2
5x39	E2x52	beta_off	4.34929	0	1	1	2	1
E2x52	Lig	Shared	9.04571	18.1917	1	1	1	0
5x39	5x43	Shared	14.8064	8.4775	1	1	2	1
5x43	Lig	Shared	6.56786	7.21333	0	0	1	0
5x461	Lig	Shared	3.68821	5.45167	0	0	1	0
5x47	6x52	Shared	32.6093	18.2183	0	1	2	1
6x44	6x48	beta_off	10.7014	0	0	1	2	1
6x44	7x45	beta_off	6.9475	0	0	1	2	2
6x48	6x51	Shared	5.83321	4.845	1	1	1	1
6x48	6x52	Shared	5.405	7.1825	1	1	1	1
6x48	7x41	Shared	12.67	11.025	1	1	1	2
6x48	Lig	beta_off	3.70571	0	1	1	1	0
6x51	6x52	Shared	7.34964	9.28917	1	1	1	1
6x51	7x34	Shared	8.23321	5.91167	1	1	1	2
6x51	7x38	Shared	11.5214	17.9233	1	1	1	1
6x51	Lig	Shared	9.09857	6.11417	1	1	1	0
6x52	Lig	Shared	12.0896	6.01083	1	1	1	0
6x55	7x34	Shared	5.02143	5.525	0	1	1	2
6x55	Lig	beta_off	8.34179	0	0	1	1	0
7x38	7x42	Shared	12.4607	8.81917	1	1	1	1
7x38	Lig	Shared	14.5632	13.93	1	1	1	0
7x39	7x42	Shared	13.3989	3.4575	0	0	2	1
7x42	Lig	Shared	4.44964	4.69	1	1	1	0
5x44	6x52	Shared	3.20571	4.62083	0	0	2	1
7x35	7x39	beta_off	2.4	0	0	0	1	2
3x28	Lig	beta_on	0	5.9025	3	0	1	0
3x40	6x48	beta_on	0	7.14417	0	0	2	1
5x44	6x55	beta_on	0	3.725	0	0	2	1
5x47	6x44	beta_on	0	6.1625	0	1	2	2
6x48	7x45	beta_on	0	8.1925	1	1	1	2
6x51	7x37	beta_on	0	3.80583	1	1	1	2
6x51	6x55	beta_on	0	4.8325	1	1	1	1
7x35	Lig	beta_on	0	2.66417	0	0	1	0
3x28	3x29	beta_on	0	1.92	3	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	beta_off	beta1_off beta2_off
	beta_on	beta1_on beta2_on beta3_on

Network Difference
Value	beta_off	beta_on
I_min	3.5375	3.33833
Number of Linked Nodes	263	263
Number of Specific Nodes	7 (2.66%)	7 (2.66%)
Number of Shared Nodes	256 (97.34%)	256 (97.34%)
Number of Links	287	295
Number of Specific Links	109 (37.98%)	117 (39.66%)
Number of Shared Links	178 (62.02%)	178 (60.34%)
Number of Hubs	31	37
Number of Specific Hubs	11 (35.48%)	17 (45.95%)
Number of Shared Hubs	20 (64.52%)	20 (54.05%)
Average % Shared Neighbours (Jaccard)	48.53
Average % Shared Neighbours (Otsuka)	56.33
Average % Shared Neighbours (Overlap Coefficient)	63.88
Average % Shared Cliques (k3-6)	57.69
Graphlets Similarity	0.62643

Paths Difference
Value	beta_off	beta_on
Number Of Nodes in MetaPath	66	67
Specific Nodes in MetaPath	29 (43.94%)	30 (44.78%)
Shared Nodes in MetaPath	256 (97.34%)	256 (97.34%)
Number Of Links MetaPath	66	69
Specific Links in MetaPath	46 (69.70%)	49 (71.01%)
Shared Links in MetaPath	178 (62.02%)	178 (62.02%)
Number of Shortest Paths	58847	59503
Length Of Smallest Path	3	3
Average Path Length	15.3214	12.1404
Length of Longest Path	32	25
Minimum Path Strength	0.560714	0.39125
Average Path Strength	6.30913	5.89601
Maximum Path Strength	22.3495	15.1436
Minimum Path Correlation	0.701071	0.7025
Average Path Correlation	0.914908	0.923424
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.33333	4.7619
Average % Of Corr. Nodes	42.3264	49.6974
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	35.1853	47.4394
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download beta_off_on.zip<

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