psnGPCR

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Orange: nodes, hubs and links specific of cannabinoid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cannabinoid_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	cannabinoid_off Int. Strength	cannabinoid_on Int. Strength	cannabinoid_off Hub1?	cannabinoid_on Hub1?	cannabinoid_off Hub2?	cannabinoid_on Hub2?	ConSurf1	ConSurf2
1	2x60	NT	cannabinoid_off	100	0	No	No	Yes	Yes	4	4
2	3x25	NT	cannabinoid_off	100	0	No	No	Yes	Yes	9	4
3	3x28	NT	cannabinoid_off	100	0	No	No	Yes	Yes	6	4
4	Lig	NT	cannabinoid_off	100	0	Yes	Yes	Yes	Yes	0	4
5	2x57	NT	cannabinoid_off	100	0	No	Yes	Yes	Yes	7	4
6	7x28	NT	cannabinoid_off	100	0	No	No	Yes	Yes	3	4
7	1x28	NT	cannabinoid_off	100	0	No	No	Yes	Yes	6	4
8	1x39	2x61	cannabinoid_off	100	0	No	No	Yes	No	7	5
9	1x45	1x49	cannabinoid_off	100	0	No	No	Yes	No	4	8
10	I1x48	I1x51	cannabinoid_off	100	0	No	No	No	No	6	8
11	2x41	4x46	cannabinoid_off	100	0	No	No	No	Yes	3	8
12	2x42	2x43	cannabinoid_off	100	0	Yes	Yes	No	No	8	8
13	2x42	6x37	cannabinoid_off	100	0	Yes	Yes	No	Yes	8	8
14	2x43	7x53	cannabinoid_off	100	0	No	No	No	Yes	8	9
15	2x46	7x53	cannabinoid_off	100	0	No	No	No	Yes	9	9
16	3x28	E1	cannabinoid_off	100	0	No	No	Yes	Yes	6	4
17	3x45	4x46	cannabinoid_off	100	0	No	No	No	Yes	6	8
18	3x49	3x50	cannabinoid_off	100	0	Yes	Yes	Yes	No	9	9
19	3x50	3x53	cannabinoid_off	100	0	Yes	No	No	No	9	8
20	3x50	5x61	cannabinoid_off	100	0	Yes	No	No	No	9	9
21	3x50	6x30	cannabinoid_off	100	0	Yes	No	Yes	Yes	9	7
22	3x50	6x33	cannabinoid_off	100	0	Yes	No	No	No	9	8
23	3x53	6x30	cannabinoid_off	100	0	No	No	Yes	Yes	8	7
24	I2x53	I2x57	cannabinoid_off	100	0	Yes	Yes	No	No	7	6
25	4x49	4x50	cannabinoid_off	100	0	No	No	Yes	Yes	6	9
26	4x60	E2	cannabinoid_off	100	0	No	No	Yes	Yes	6	4
27	6x55	E2	cannabinoid_off	100	0	No	No	Yes	Yes	6	4
28	5x40	6x59	cannabinoid_off	100	0	No	No	No	No	5	4
29	5x58	6x38	cannabinoid_off	100	0	Yes	Yes	No	No	9	6
30	5x63	5x64	cannabinoid_off	100	0	No	No	Yes	No	3	5
31	5x64	5x67	cannabinoid_off	100	0	Yes	No	No	No	5	5
32	6x25	6x28	cannabinoid_off	100	0	No	No	No	No	3	4
33	6x26	6x30	cannabinoid_off	100	0	No	No	Yes	Yes	5	7
34	6x32	8x48	cannabinoid_off	100	0	No	No	No	No	7	5
35	6x40	7x49	cannabinoid_off	100	0	No	No	Yes	No	8	9
36	6x43	7x48	cannabinoid_off	100	0	No	No	No	No	6	6
37	6x44	7x45	cannabinoid_off	100	0	No	No	Yes	No	9	9
38	6x48	Lig	cannabinoid_off	100	0	Yes	Yes	Yes	Yes	8	0
39	6x50	7x37	cannabinoid_off	100	0	No	No	No	No	9	5
40	6x51	7x34	cannabinoid_off	100	0	No	No	No	No	7	4
41	6x51	7x41	cannabinoid_off	100	0	No	No	No	No	7	7
42	6x51	Lig	cannabinoid_off	100	0	No	No	Yes	Yes	7	0
43	6x58	E3	cannabinoid_off	100	0	No	No	No	Yes	4	1
44	7x27	7x29	cannabinoid_off	100	0	No	No	No	No	1	4
45	7x27	7x30	cannabinoid_off	100	0	No	No	No	No	1	3
46	7x39	Lig	cannabinoid_off	100	0	No	No	Yes	Yes	5	0
47	7x41	Lig	cannabinoid_off	100	0	No	No	Yes	Yes	7	0
48	7x49	7x53	cannabinoid_off	100	0	Yes	No	No	Yes	9	9
49	2x39	3x50	cannabinoid_off	100	0	No	No	Yes	No	8	9
50	4x59	5x39	cannabinoid_off	100	0	No	No	No	Yes	5	7
51	5x37	6x59	cannabinoid_off	100	0	No	No	No	No	3	4
52	5x59	5x63	cannabinoid_off	100	0	No	No	No	No	3	3
53	6x35	7x56	cannabinoid_off	100	0	No	No	Yes	No	7	7
54	6x44	6x48	cannabinoid_off	100	0	No	No	Yes	Yes	9	8
55	2x48	2x52	cannabinoid_off	100	0	No	No	No	No	6	6
56	3x54	5x68	cannabinoid_off	100	0	No	No	No	No	9	7
57	5x58	5x62	cannabinoid_off	100	0	Yes	Yes	No	No	9	6
58	5x68	I3	cannabinoid_off	100	0	No	No	No	Yes	7	3.4
59	6x28	8x48	cannabinoid_off	100	0	No	No	No	No	4	5
60	1x53	2x47	cannabinoid_off	25	0	No	No	No	No	9	9
61	3x22	3x23	cannabinoid_off	50	0	No	No	No	No	3	1
62	2x48	4x50	cannabinoid_off	50	0	No	No	Yes	Yes	6	9
63	1x47	2x54	cannabinoid_off	50	0	No	No	No	No	6	7
64	3x36	3x40	cannabinoid_off	50	0	Yes	Yes	No	No	7	7
65	5x42	E2	cannabinoid_off	50	0	No	No	Yes	Yes	6	4
66	5x43	5x44	cannabinoid_off	50	0	Yes	Yes	No	No	6	5
67	1x57	I1x50	cannabinoid_off	50	0	No	No	No	No	7	9
68	5x51	6x45	cannabinoid_off	50	0	No	Yes	No	No	6	6
69	2x42	3x46	cannabinoid_off	50	0	Yes	Yes	No	No	8	9
70	I2x52	I2x55	cannabinoid_off	50	0	No	No	No	No	5	4
71	1x40	2x61	cannabinoid_off	50	0	No	No	Yes	No	3	5
72	1x29	1x32	cannabinoid_off	50	0	No	No	No	No	2	4
73	2x46	3x39	cannabinoid_off	0	0	No	No	No	No	9	9
74	3x52	I2x57	cannabinoid_off	50	0	No	No	No	No	5	6
75	6x29	6x32	cannabinoid_off	50	0	No	No	No	No	6	7
76	6x54	7x30	cannabinoid_off	50	0	No	No	No	No	4	3
77	6x32	7x56	cannabinoid_off	50	0	No	No	Yes	No	7	7
78	1x47	2x55	cannabinoid_off	50	0	No	No	No	No	6	4
79	2x38	I2x53	cannabinoid_off	50	0	No	No	Yes	Yes	5	7
80	6x30	I3	cannabinoid_off	50	0	Yes	Yes	No	Yes	7	3.4
81	6x26	6x29	cannabinoid_off	50	0	No	No	No	No	5	6
82	8x49	I1x49	cannabinoid_off	50	0	No	Yes	No	No	6	5
83	3x31	4x58	cannabinoid_off	50	0	No	No	Yes	No	4	5
84	4x58	4x62	cannabinoid_off	50	0	Yes	No	No	No	5	5
85	6x47	7x43	cannabinoid_off	25	0	No	No	No	No	8	5
86	3x43	5x58	cannabinoid_off	50	0	No	No	Yes	Yes	8	9
87	2x38	4x42	cannabinoid_off	25	0	No	No	No	No	5	7
88	6x43	7x45	cannabinoid_off	25	0	No	No	Yes	No	6	9
89	1x57	2x44	cannabinoid_off	0	0	No	No	No	No	7	6
90	3x30	4x58	cannabinoid_off	50	0	No	No	Yes	No	6	5
91	1x43	7x42	cannabinoid_off	50	0	No	No	No	No	6	7
92	3x36	6x52	cannabinoid_off	50	0	Yes	Yes	No	No	7	7
93	4x54	4x58	cannabinoid_off	0	0	No	No	Yes	No	4	5
94	3x50	6x34	cannabinoid_off	0	0	Yes	No	No	No	9	7
95	5x68	6x31	cannabinoid_off	50	0	No	No	No	No	7	5
96	5x65	6x31	cannabinoid_off	0	0	No	No	No	No	8	5
97	2x41	4x39	cannabinoid_off	25	0	No	No	No	No	3	1
98	1x60	I1x48	cannabinoid_off	50	0	Yes	No	No	No	6	6
99	1x35	2x61	cannabinoid_off	50	0	No	No	Yes	No	5	5
100	8x51	8x55	cannabinoid_off	50	0	No	No	No	No	8	5
101	7x55	8x51	cannabinoid_off	50	0	No	No	No	No	5	8
102	5x69	I3	cannabinoid_off	0	0	No	No	No	Yes	5	3.4
103	5x66	6x31	cannabinoid_off	25	0	No	No	No	No	5	5
104	6x60	6x61	cannabinoid_off	0	0	No	No	No	No	5	3
105	7x35	NT	cannabinoid_off	25	0	No	No	Yes	Yes	4	4
106	7x30	7x33	cannabinoid_off	0	0	No	No	No	No	3	4
107	4x55	4x59	cannabinoid_off	0	0	No	No	No	No	3	5
108	5x49	5x53	cannabinoid_off	25	0	No	No	No	No	6	6
109	1x60	8x57	cannabinoid_off	0	0	Yes	No	No	No	6	5
110	4x43	4x47	cannabinoid_off	0	0	No	No	No	No	1	4
111	1x54	1x58	cannabinoid_off	0	0	No	No	No	No	7	4
112	8x54	8x58	cannabinoid_off	0	0	No	No	No	No	7	5
113	6x24	6x27	cannabinoid_off	0	0	No	No	No	No	2	4
114	5x69	6x27	cannabinoid_off	0	0	No	No	No	No	5	4
115	1x44	2x58	cannabinoid_off	0	0	No	No	No	No	5	7
116	1x33	1x37	cannabinoid_off	0	0	No	No	No	No	5	4
117	1x52	1x56	cannabinoid_off	0	0	No	No	No	No	7	8
118	1x59	8x56	cannabinoid_off	0	0	No	No	No	No	5	3
119	NT	NT	Shared	100	100	Yes	Yes	Yes	Yes	4	4
120	E1	NT	Shared	100	100	Yes	Yes	Yes	Yes	4	4
121	E2	NT	Shared	100	100	Yes	Yes	Yes	Yes	4	4
122	2x64	NT	Shared	100	100	No	Yes	Yes	Yes	4	4
123	7x31	NT	Shared	100	100	No	No	Yes	Yes	2	4
124	7x32	NT	Shared	100	100	No	No	Yes	Yes	1	4
125	1x32	NT	Shared	100	50	No	No	Yes	Yes	4	4
126	1x39	7x39	Shared	100	100	No	No	No	No	7	5
127	1x46	2x54	Shared	100	100	No	No	No	No	7	7
128	1x46	7x47	Shared	100	100	No	No	No	Yes	7	7
129	1x49	7x47	Shared	100	100	Yes	No	No	Yes	8	7
130	1x49	7x50	Shared	100	100	Yes	No	No	No	8	9
131	1x50	2x50	Shared	100	100	No	Yes	No	Yes	9	9
132	1x50	7x50	Shared	100	100	No	Yes	No	No	9	9
133	1x59	8x57	Shared	100	100	No	No	No	No	5	5
134	1x60	I1x50	Shared	100	100	Yes	No	No	No	6	9
135	1x60	8x53	Shared	100	58.3333	Yes	No	No	No	6	7
136	2x40	I1x50	Shared	100	100	Yes	Yes	No	No	9	9
137	2x37	2x40	Shared	100	100	No	No	Yes	Yes	5	9
138	2x37	8x49	Shared	100	100	No	No	No	Yes	5	6
139	2x39	2x40	Shared	100	58.3333	No	No	Yes	Yes	8	9
140	2x40	8x47	Shared	100	100	Yes	Yes	No	No	9	8
141	2x40	8x49	Shared	100	100	Yes	Yes	No	Yes	9	6
142	2x45	3x42	Shared	100	100	No	No	No	No	9	8
143	2x45	4x46	Shared	100	100	No	No	No	Yes	9	8
144	2x45	4x50	Shared	100	100	No	No	Yes	Yes	9	9
145	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
146	2x50	7x49	Shared	100	100	No	Yes	Yes	No	9	9
147	2x51	2x55	Shared	100	50	No	Yes	No	No	7	4
148	2x57	7x42	Shared	100	100	No	Yes	No	No	7	7
149	2x57	Lig	Shared	100	100	No	Yes	Yes	Yes	7	0
150	2x59	2x63	Shared	100	100	No	No	No	No	7	3
151	2x60	3x28	Shared	100	100	No	No	No	No	4	6
152	2x61	2x65	Shared	100	100	Yes	No	No	Yes	5	4
153	2x62	2x66	Shared	100	66.6667	No	No	No	No	5	4
154	2x63	E1	Shared	100	100	No	No	Yes	Yes	3	4
155	2x64	2x65	Shared	100	100	No	Yes	No	Yes	4	4
156	2x66	E1	Shared	100	100	No	No	Yes	Yes	4	4
157	3x24	E1	Shared	100	100	No	No	Yes	Yes	5	4
158	3x21	3x24	Shared	100	100	No	No	No	No	7	5
159	3x22	E2	Shared	100	100	No	No	Yes	Yes	3	4
160	3x25	E2	Shared	100	100	No	No	Yes	Yes	9	4
161	3x26	4x61	Shared	100	100	No	No	No	No	5	5
162	3x26	E2	Shared	100	100	No	No	Yes	Yes	5	4
163	3x29	E2	Shared	100	100	No	No	Yes	Yes	4	4
164	3x29	Lig	Shared	100	100	No	No	Yes	Yes	4	0
165	3x32	Lig	Shared	100	100	No	No	Yes	Yes	7	0
166	3x33	5x43	Shared	100	100	No	Yes	Yes	Yes	6	6
167	3x33	Lig	Shared	100	100	No	Yes	Yes	Yes	6	0
168	3x36	6x48	Shared	100	100	Yes	Yes	Yes	Yes	7	8
169	3x37	4x53	Shared	100	100	No	No	No	No	6	8
170	3x37	5x43	Shared	100	100	No	No	Yes	Yes	6	6
171	3x38	4x50	Shared	100	100	No	No	Yes	Yes	7	9
172	3x40	5x50	Shared	100	100	No	No	No	Yes	7	8
173	3x40	5x51	Shared	100	100	No	No	No	Yes	7	6
174	3x41	4x49	Shared	100	100	No	No	No	No	5	6
175	3x44	3x48	Shared	100	100	Yes	Yes	No	No	7	7
176	3x44	5x50	Shared	100	100	Yes	Yes	No	Yes	7	8
177	3x44	5x54	Shared	100	100	Yes	Yes	No	No	7	8
178	3x45	4x49	Shared	100	100	No	No	No	No	6	6
179	3x49	I2x53	Shared	100	100	Yes	Yes	Yes	Yes	9	7
180	3x49	I2x57	Shared	100	100	Yes	Yes	No	No	9	6
181	3x51	3x55	Shared	100	100	No	No	No	Yes	8	6
182	3x52	I2x56	Shared	100	25	No	No	No	No	5	4
183	3x53	I2x53	Shared	100	100	No	No	Yes	Yes	8	7
184	3x55	3x56	Shared	100	100	No	Yes	No	No	6	5
185	4x38	4x41	Shared	100	100	No	No	No	No	8	5
186	4x59	E2	Shared	100	100	No	No	Yes	Yes	5	4
187	4x60	5x39	Shared	100	100	No	No	No	Yes	6	7
188	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	4	4
189	5x36	E2	Shared	100	100	No	No	Yes	Yes	5	4
190	5x38	E2	Shared	100	100	No	No	Yes	Yes	5	4
191	5x39	E2	Shared	100	100	No	Yes	Yes	Yes	7	4
192	5x37	E2	Shared	100	100	No	No	Yes	Yes	3	4
193	6x58	E2	Shared	100	100	No	No	Yes	Yes	4	4
194	E2	E3	Shared	100	100	Yes	Yes	No	Yes	4	1
195	7x31	E2	Shared	100	100	No	No	Yes	Yes	2	4
196	7x34	E2	Shared	100	100	No	No	Yes	Yes	4	4
197	E2	Lig	Shared	100	100	Yes	Yes	Yes	Yes	4	0
198	5x40	E2	Shared	100	100	No	No	Yes	Yes	5	4
199	5x36	5x38	Shared	100	100	No	No	No	No	5	5
200	5x41	6x59	Shared	100	100	No	No	No	No	4	4
201	5x43	5x47	Shared	100	100	Yes	Yes	No	No	6	8
202	5x43	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
203	5x46	5x50	Shared	100	100	No	No	No	Yes	6	8
204	5x58	6x37	Shared	100	100	Yes	Yes	No	Yes	9	8
205	5x58	6x41	Shared	100	100	Yes	Yes	No	No	9	8
206	5x60	5x64	Shared	100	100	No	Yes	Yes	No	4	5
207	6x36	7x56	Shared	100	100	No	No	Yes	No	8	7
208	6x39	7x56	Shared	100	100	No	No	Yes	No	7	7
209	6x47	7x45	Shared	100	100	No	No	Yes	No	8	9
210	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
211	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	8	9
212	6x49	6x50	Shared	100	100	No	No	No	No	5	9
213	6x54	7x34	Shared	100	100	No	No	No	No	4	4
214	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
215	7x45	7x49	Shared	100	100	Yes	No	Yes	No	9	9
216	8x47	8x50	Shared	100	100	No	No	No	No	8	8
217	8x48	8x51	Shared	100	100	No	No	No	No	5	8
218	1x28	1x31	Shared	100	100	No	No	No	No	6	2
219	4x39	I1	Shared	100	41.6667	No	No	No	No	1	7
220	3x33	4x57	Shared	100	100	No	Yes	No	No	6	7
221	5x56	5x60	Shared	100	100	No	No	No	Yes	4	4
222	1x38	7x39	Shared	100	100	No	No	No	No	5	5
223	1x55	1x59	Shared	100	100	No	No	No	No	4	5
224	2x42	3x49	Shared	100	100	Yes	Yes	Yes	Yes	8	9
225	2x64	Lig	Shared	100	100	No	Yes	Yes	Yes	4	0
226	3x36	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
227	6x57	6x61	Shared	100	50	No	No	No	No	4	3
228	3x51	5x60	Shared	50	100	No	No	No	Yes	8	4
229	5x55	6x41	Shared	50	100	No	No	No	No	5	8
230	3x54	5x64	Shared	50	100	No	No	Yes	No	9	5
231	1x56	8x54	Shared	25	50	No	No	No	No	8	7
232	3x34	4x57	Shared	50	100	No	No	No	No	5	7
233	6x57	E3	Shared	50	100	No	No	No	Yes	4	1
234	4x38	4x40	Shared	50	100	No	No	No	No	8	4
235	3x56	I2x52	Shared	50	16.6667	No	No	No	No	5	5
236	1x51	2x51	Shared	50	50	No	No	No	Yes	3	7
237	2x46	3x42	Shared	50	100	No	No	No	No	9	8
238	3x34	4x58	Shared	50	100	No	No	Yes	No	5	5
239	2x52	3x35	Shared	0	66.6667	No	No	No	No	6	7
240	1x54	2x48	Shared	50	100	No	No	No	No	7	6
241	I2x50	I2x51	Shared	50	100	No	No	No	No	8	7
242	1x42	7x47	Shared	25	100	No	No	No	Yes	6	7
243	2x41	4x43	Shared	50	50	No	No	No	No	3	1
244	1x54	2x47	Shared	0	66.6667	No	No	No	No	7	9
245	1x56	8x53	Shared	50	25	No	No	No	No	8	7
246	3x47	5x58	Shared	50	100	No	No	Yes	Yes	8	9
247	4x56	5x46	Shared	50	100	No	No	No	No	5	6
248	6x40	7x52	Shared	50	100	No	No	No	Yes	8	9
249	2x53	3x35	Shared	25	100	No	No	No	No	8	7
250	4x63	E2	Shared	50	58.3333	No	No	Yes	Yes	5	4
251	2x49	4x50	Shared	0	33.3333	No	No	Yes	Yes	8	9
252	1x44	1x48	Shared	0	8.33333	No	No	No	No	5	3
253	1x55	8x61	Shared	50	16.6667	No	No	No	No	4	0
254	6x54	7x37	Shared	25	41.6667	No	No	No	No	4	5
255	3x51	5x57	Shared	25	100	No	No	No	No	8	7
256	1x49	7x51	Shared	0	100	Yes	No	No	No	8	6
257	1x29	1x30	Shared	50	50	No	No	No	No	2	5
258	6x47	7x40	Shared	0	16.6667	No	No	No	No	8	7
259	1x35	7x36	Shared	50	100	No	No	No	No	5	4
260	2x56	3x32	Shared	0	50	No	No	No	No	5	7
261	1x43	2x58	Shared	0	0	No	No	No	No	6	7
262	1x36	2x66	Shared	0	50	No	No	No	No	5	4
263	3x45	4x45	Shared	25	50	No	No	No	No	6	5
264	6x42	6x46	Shared	0	16.6667	No	No	No	No	6	5
265	1x32	1x33	Shared	0	16.6667	No	No	No	No	4	5
266	4x48	4x52	Shared	0	50	No	No	No	Yes	3	5
267	8x58	8x62	Shared	0	16.6667	No	No	No	No	5	0
268	5x45	5x48	Shared	25	16.6667	No	No	No	No	3	5
269	5x41	5x45	Shared	0	8.33333	No	No	No	No	4	3
270	6x49	6x53	Shared	0	16.6667	No	No	No	No	5	5
271	3x44	5x53	Shared	25	100	Yes	Yes	No	No	7	6
272	3x27	4x61	Shared	0	75	No	No	No	No	5	5
273	5x44	6x56	Shared	0	16.6667	No	No	No	No	5	6
274	1x37	1x41	Shared	0	16.6667	No	No	No	No	4	4
275	4x44	4x48	Shared	0	0	No	No	No	No	3	3
276	8x52	8x56	Shared	25	8.33333	No	No	No	No	4	3
277	5x66	5x70	Shared	25	50	No	No	No	No	5	5
278	6x38	6x42	Shared	0	0	No	No	No	No	6	6
279	4x52	4x56	Shared	0	25	No	Yes	No	No	5	5
280	3x56	I2x50	Shared	0	16.6667	No	No	No	No	5	8
281	4x39	4x40	Shared	0	8.33333	No	No	No	No	1	4
282	I2x53	I2x54	Shared	0	100	Yes	Yes	No	No	7	4
283	4x51	4x52	Shared	0	16.6667	No	No	No	Yes	4	5
284	1x31	NT	cannabinoid_on	0	100	No	No	Yes	Yes	2	4
285	1x28	1x29	cannabinoid_on	0	100	No	No	No	No	6	2
286	1x31	7x36	cannabinoid_on	0	100	No	No	No	No	2	4
287	1x47	2x51	cannabinoid_on	0	100	No	No	No	Yes	6	7
288	1x57	2x40	cannabinoid_on	0	100	No	No	Yes	Yes	7	9
289	8x49	I1x50	cannabinoid_on	0	100	No	Yes	No	No	6	9
290	2x38	I2x57	cannabinoid_on	0	100	No	No	No	No	5	6
291	2x39	3x49	cannabinoid_on	0	100	No	No	Yes	Yes	8	9
292	2x40	8x50	cannabinoid_on	0	100	Yes	Yes	No	No	9	8
293	2x42	3x45	cannabinoid_on	0	100	Yes	Yes	No	No	8	6
294	2x46	3x43	cannabinoid_on	0	100	No	No	No	No	9	8
295	2x46	7x49	cannabinoid_on	0	100	No	No	Yes	No	9	9
296	2x57	2x61	cannabinoid_on	0	100	No	Yes	Yes	No	7	5
297	2x57	7x38	cannabinoid_on	0	100	No	Yes	No	No	7	6
298	2x60	Lig	cannabinoid_on	0	100	No	No	Yes	Yes	4	0
299	2x61	Lig	cannabinoid_on	0	100	Yes	No	Yes	Yes	5	0
300	2x65	Lig	cannabinoid_on	0	100	No	Yes	Yes	Yes	4	0
301	3x25	E1	cannabinoid_on	0	100	No	No	Yes	Yes	9	4
302	3x26	4x60	cannabinoid_on	0	100	No	No	No	No	5	6
303	3x36	7x41	cannabinoid_on	0	100	Yes	Yes	No	No	7	7
304	3x43	7x53	cannabinoid_on	0	100	No	No	No	Yes	8	9
305	3x46	3x50	cannabinoid_on	0	100	No	No	Yes	No	9	9
306	3x46	7x53	cannabinoid_on	0	100	No	No	No	Yes	9	9
307	3x50	5x58	cannabinoid_on	0	100	Yes	No	Yes	Yes	9	9
308	3x50	7x53	cannabinoid_on	0	100	Yes	No	No	Yes	9	9
309	3x54	5x61	cannabinoid_on	0	100	No	No	No	No	9	9
310	3x55	5x60	cannabinoid_on	0	100	No	Yes	No	Yes	6	4
311	4x46	4x50	cannabinoid_on	0	100	No	Yes	Yes	Yes	8	9
312	5x39	Lig	cannabinoid_on	0	100	No	Yes	Yes	Yes	7	0
313	5x43	6x55	cannabinoid_on	0	100	Yes	Yes	No	No	6	6
314	5x44	6x55	cannabinoid_on	0	100	No	No	No	No	5	6
315	5x47	5x51	cannabinoid_on	0	100	No	No	No	Yes	8	6
316	5x51	6x44	cannabinoid_on	0	100	No	Yes	No	No	6	9
317	5x51	6x48	cannabinoid_on	0	100	No	Yes	Yes	Yes	6	8
318	5x58	6x40	cannabinoid_on	0	100	Yes	Yes	No	No	9	8
319	5x58	7x53	cannabinoid_on	0	100	Yes	Yes	No	Yes	9	9
320	5x60	5x63	cannabinoid_on	0	100	No	Yes	No	No	4	3
321	5x62	6x37	cannabinoid_on	0	100	No	No	No	Yes	6	8
322	5x66	6x30	cannabinoid_on	0	100	No	No	Yes	Yes	5	7
323	5x69	6x30	cannabinoid_on	0	100	No	No	Yes	Yes	5	7
324	6x28	6x32	cannabinoid_on	0	100	No	No	No	No	4	7
325	6x39	7x52	cannabinoid_on	0	100	No	No	No	Yes	7	9
326	6x40	7x53	cannabinoid_on	0	100	No	No	No	Yes	8	9
327	6x43	7x52	cannabinoid_on	0	100	No	No	No	Yes	6	9
328	7x30	E3	cannabinoid_on	0	100	No	No	No	Yes	3	1
329	7x34	Lig	cannabinoid_on	0	100	No	No	Yes	Yes	4	0
330	7x48	7x52	cannabinoid_on	0	100	No	No	No	Yes	6	9
331	7x51	7x55	cannabinoid_on	0	100	No	No	No	No	6	5
332	2x65	NT	cannabinoid_on	0	100	No	Yes	Yes	Yes	4	4
333	4x39	I1x51	cannabinoid_on	0	100	No	No	No	No	1	8
334	2x57	3x32	cannabinoid_on	0	100	No	Yes	No	No	7	7
335	2x64	E1	cannabinoid_on	0	100	No	Yes	Yes	Yes	4	4
336	3x25	3x29	cannabinoid_on	0	100	No	No	No	No	9	4
337	3x55	5x64	cannabinoid_on	0	100	No	Yes	Yes	No	6	5
338	5x39	5x43	cannabinoid_on	0	100	No	Yes	Yes	Yes	7	6
339	6x48	6x51	cannabinoid_on	0	100	Yes	Yes	No	No	8	7
340	6x48	6x52	cannabinoid_on	0	100	Yes	Yes	No	No	8	7
341	7x29	7x32	cannabinoid_on	0	100	No	No	No	No	4	1
342	2x57	3x36	cannabinoid_on	0	100	No	Yes	Yes	Yes	7	7
343	5x63	5x67	cannabinoid_on	0	100	No	No	No	No	3	5
344	I3	I3	cannabinoid_on	0	100	No	Yes	No	Yes	3.4	3.4
345	1x45	7x47	cannabinoid_on	0	50	No	No	No	Yes	4	7
346	3x30	3x33	cannabinoid_on	0	75	No	No	No	Yes	6	6
347	1x53	7x54	cannabinoid_on	0	75	No	No	No	No	9	7
348	1x59	I1x48	cannabinoid_on	0	50	No	No	No	No	5	6
349	5x61	6x37	cannabinoid_on	0	33.3333	No	No	No	Yes	9	8
350	5x69	6x29	cannabinoid_on	0	66.6667	No	No	No	No	5	6
351	5x68	5x72	cannabinoid_on	0	50	No	No	No	No	7	0
352	1x35	7x39	cannabinoid_on	0	58.3333	No	No	No	No	5	5
353	1x50	2x51	cannabinoid_on	0	50	No	Yes	No	Yes	9	7
354	1x56	8x57	cannabinoid_on	0	41.6667	No	No	No	No	8	5
355	2x50	3x39	cannabinoid_on	0	50	No	Yes	No	No	9	9
356	1x60	I1x51	cannabinoid_on	0	50	Yes	No	No	No	6	8
357	6x59	6x60	cannabinoid_on	0	50	No	No	No	No	4	5
358	7x54	8x50	cannabinoid_on	0	33.3333	No	No	No	No	7	8
359	5x62	6x34	cannabinoid_on	0	25	No	No	No	No	6	7
360	6x30	6x31	cannabinoid_on	0	58.3333	Yes	Yes	No	No	7	5
361	8x48	8x49	cannabinoid_on	0	50	No	No	No	Yes	5	6
362	1x50	2x47	cannabinoid_on	0	50	No	Yes	No	No	9	9
363	6x57	6x59	cannabinoid_on	0	50	No	No	No	No	4	4
364	2x42	4x42	cannabinoid_on	0	41.6667	Yes	Yes	No	No	8	7
365	3x21	3x23	cannabinoid_on	0	50	No	No	No	No	7	1
366	8x60	8x61	cannabinoid_on	0	50	No	No	No	No	0	0
367	1x43	1x46	cannabinoid_on	0	50	No	No	No	No	6	7
368	2x42	4x46	cannabinoid_on	0	50	Yes	Yes	No	Yes	8	8
369	2x56	3x31	cannabinoid_on	0	66.6667	No	No	No	No	5	4
370	3x52	I2x53	cannabinoid_on	0	16.6667	No	No	Yes	Yes	5	7
371	5x42	5x46	cannabinoid_on	0	50	No	No	No	No	6	6
372	I1	I1x49	cannabinoid_on	0	50	No	No	No	No	7	5
373	3x34	4x54	cannabinoid_on	0	33.3333	No	No	No	No	5	4
374	2x53	3x36	cannabinoid_on	0	50	No	No	Yes	Yes	8	7
375	2x44	2x47	cannabinoid_on	0	0	No	No	No	No	6	9
376	5x68	6x29	cannabinoid_on	0	16.6667	No	No	No	No	7	6
377	1x42	7x43	cannabinoid_on	0	50	No	No	No	No	6	5
378	2x40	2x43	cannabinoid_on	0	33.3333	Yes	Yes	No	No	9	8
379	7x27	E3	cannabinoid_on	0	16.6667	No	No	No	Yes	1	1
380	8x52	8x55	cannabinoid_on	0	50	No	No	No	No	4	5
381	2x41	4x42	cannabinoid_on	0	25	No	No	No	No	3	7
382	6x31	6x35	cannabinoid_on	0	50	No	No	No	No	5	7
383	6x50	7x40	cannabinoid_on	0	25	No	No	No	No	9	7
384	5x65	6x33	cannabinoid_on	0	0	No	No	No	No	8	8
385	7x27	7x28	cannabinoid_on	0	33.3333	No	No	No	No	1	3
386	6x29	6x33	cannabinoid_on	0	8.33333	No	No	No	No	6	8
387	5x72	I3	cannabinoid_on	0	33.3333	No	No	No	Yes	0	3.4
388	6x28	6x31	cannabinoid_on	0	25	No	No	No	No	4	5
389	6x33	6x37	cannabinoid_on	0	8.33333	No	No	No	Yes	8	8
390	4x61	4x62	cannabinoid_on	0	16.6667	No	No	No	No	5	5
391	8x48	8x52	cannabinoid_on	0	16.6667	No	No	No	No	5	4
392	1x41	1x42	cannabinoid_on	0	16.6667	No	No	No	No	4	6
393	1x52	8x54	cannabinoid_on	0	16.6667	No	No	No	No	7	7
394	1x58	I1x51	cannabinoid_on	0	16.6667	No	No	No	No	4	8
395	8x60	8x63	cannabinoid_on	0	8.33333	No	No	No	No	0	0
396	2x65	7x35	cannabinoid_on	0	0	No	Yes	No	No	4	4
397	5x55	6x45	cannabinoid_on	0	8.33333	No	No	No	No	5	6
398	6x27	6x30	cannabinoid_on	0	16.6667	No	No	Yes	Yes	4	7
399	1x39	1x40	cannabinoid_on	0	16.6667	No	No	No	No	7	3
400	5x49	5x50	cannabinoid_on	0	0	No	No	No	Yes	6	8
401	4x52	4x55	cannabinoid_on	0	8.33333	No	Yes	No	No	5	3
402	6x46	6x47	cannabinoid_on	0	0	No	No	No	No	5	8
403	6x54	7x33	cannabinoid_on	0	0	No	No	No	No	4	4
404	5x75	5x76	cannabinoid_on	0	0	No	No	No	No	0	0
405	5x59	6x41	cannabinoid_on	0	0	No	No	No	No	3	8
406	5x67	5x71	cannabinoid_on	0	0	No	No	No	No	5	0
407	4x46	4x47	cannabinoid_on	0	0	No	Yes	No	No	8	4
408	I2x55	I2x56	cannabinoid_on	0	0	No	No	No	No	4	4
409	1x34	1x38	cannabinoid_on	0	0	No	No	No	No	5	5
410	5x73	I3	cannabinoid_on	0	0	No	No	No	Yes	0	3.4
411	5x76	I3	cannabinoid_on	0	0	No	No	No	Yes	0	3.4
412	1x45	1x48	cannabinoid_on	0	0	No	No	No	No	4	3
413	8x55	8x58	cannabinoid_on	0	0	No	No	No	No	5	5
414	5x52	5x53	cannabinoid_on	0	0	No	No	No	No	4	6
415	5x73	5x74	cannabinoid_on	0	0	No	No	No	No	0	0

Orange: nodes, hubs and links specific of cannabinoid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cannabinoid_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	cannabinoid_off Avg Int. Strength	cannabinoid_on Avg Int. Strength	cannabinoid_off Num Of Links	cannabinoid_on Num Of Links	ConSurf
1	1x49	cannabinoid_off	0	0	4	3	8
2	1x60	cannabinoid_off	0	0	4	3	6
3	2x61	cannabinoid_off	75	75	4	3	5
4	3x50	cannabinoid_off	100	0	7	3	9
5	4x58	cannabinoid_off	0	0	5	1	5
6	5x64	cannabinoid_off	0	0	4	3	5
7	7x45	cannabinoid_off	50	0	5	3	9
8	7x49	cannabinoid_off	25	0	4	3	9
9	7x56	cannabinoid_off	0	0	4	2	7
10	NT	Shared	100	83.3333	16	10	4
11	2x40	Shared	100	100	5	8	9
12	2x42	Shared	25	0	4	4	8
13	E1	Shared	100	100	5	6	4
14	3x36	Shared	50	41.6667	4	5	7
15	3x44	Shared	0	0	4	4	7
16	3x49	Shared	50	50	4	4	9
17	I2x53	Shared	100	0	5	4	7
18	4x50	Shared	50	25	5	4	9
19	E2	Shared	100	100	22	19	4
20	5x43	Shared	100	100	5	6	6
21	5x58	Shared	75	100	6	6	9
22	6x30	Shared	0	0	4	4	7
23	6x48	Shared	100	100	5	6	8
24	Lig	Shared	100	100	14	14	0
25	1x50	cannabinoid_on	0	0	2	4	9
26	2x50	cannabinoid_on	50	33.3333	3	4	9
27	2x51	cannabinoid_on	0	0	2	4	7
28	2x57	cannabinoid_on	50	50	3	6	7
29	2x64	cannabinoid_on	0	41.6667	3	4	4
30	2x65	cannabinoid_on	0	33.3333	2	5	4
31	3x33	cannabinoid_on	0	0	3	4	6
32	3x55	cannabinoid_on	0	0	2	4	6
33	4x46	cannabinoid_on	0	0	3	4	8
34	4x52	cannabinoid_on	0	0	3	4	5
35	5x39	cannabinoid_on	0	0	3	4	7
36	5x50	cannabinoid_on	0	0	3	4	8
37	5x51	cannabinoid_on	0	50	2	4	6
38	5x60	cannabinoid_on	0	50	3	5	4
39	6x37	cannabinoid_on	0	0	2	4	8
40	E3	cannabinoid_on	0	33.3333	3	4	1
41	7x47	cannabinoid_on	0	0	3	4	7
42	7x52	cannabinoid_on	0	33.3333	1	4	9
43	7x53	cannabinoid_on	25	75	3	5	9
44	8x49	cannabinoid_on	50	16.6667	3	4	6
45	I3	cannabinoid_on	0	0	3	5	3.4

Orange: nodes, hubs and links specific of cannabinoid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cannabinoid_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	cannabinoid_off Recurrence	cannabinoid_on Recurrence	cannabinoid_off Hub1?	cannabinoid_on Hub1?	cannabinoid_off Hub2?	cannabinoid_on Hub2?	ConSurf1	ConSurf2
1	Lig	NT	cannabinoid_off	20.4618	0	Yes	Yes	Yes	Yes	0	4
2	6x48	Lig	cannabinoid_off	79.578	0	Yes	Yes	Yes	Yes	8	0
3	2x39	3x50	cannabinoid_off	31.8869	0	No	No	Yes	No	8	9
4	3x49	3x50	cannabinoid_off	70.6409	0	Yes	Yes	Yes	No	9	9
5	2x42	2x43	cannabinoid_off	85.002	0	Yes	Yes	No	No	8	8
6	2x43	7x53	cannabinoid_off	85.5394	0	No	No	No	Yes	8	9
7	7x49	7x53	cannabinoid_off	97.0342	0	Yes	No	No	Yes	9	9
8	2x41	4x46	cannabinoid_off	11.1714	0	No	No	No	Yes	3	8
9	2x46	7x53	cannabinoid_off	36.3505	0	No	No	No	Yes	9	9
10	2x45	4x50	cannabinoid_off	17.6304	3.19253	No	No	Yes	Yes	9	9
11	3x33	Lig	cannabinoid_off	10.5046	6.74591	No	Yes	Yes	Yes	6	0
12	3x36	3x40	cannabinoid_off	19.4367	0	Yes	Yes	No	No	7	7
13	3x51	5x60	cannabinoid_off	11.2609	2.56846	No	No	No	Yes	8	4
14	5x60	5x64	cannabinoid_off	13.9779	8.67332	No	Yes	Yes	No	4	5
15	3x54	5x68	cannabinoid_off	20.5165	0	No	No	No	No	9	7
16	5x68	I3	cannabinoid_off	26.0848	0	No	No	No	Yes	7	3.4
17	6x30	I3	cannabinoid_off	30.0856	0	Yes	Yes	No	Yes	7	3.4
18	3x50	6x30	cannabinoid_off	44.0635	0	Yes	No	Yes	Yes	9	7
19	2x42	6x37	cannabinoid_off	13.2962	0	Yes	Yes	No	Yes	8	8
20	6x29	6x32	cannabinoid_off	14.7641	0	No	No	No	No	6	7
21	6x26	6x29	cannabinoid_off	16.0928	0	No	No	No	No	5	6
22	6x26	6x30	cannabinoid_off	17.1726	0	No	No	Yes	Yes	5	7
23	6x54	7x37	cannabinoid_off	12.296	1.29484	No	No	No	No	4	5
24	6x54	7x34	cannabinoid_off	27.4482	3.86754	No	No	No	No	4	4
25	7x34	E2	cannabinoid_off	13.0573	1.02314	No	No	Yes	Yes	4	4
26	6x54	7x30	cannabinoid_off	12.296	0	No	No	No	No	4	3
27	2x48	4x50	cannabinoid_off	11.1764	0	No	No	Yes	Yes	6	9
28	6x51	Lig	cannabinoid_off	10.843	0	No	No	Yes	Yes	7	0
29	6x51	7x34	cannabinoid_off	17.0482	0	No	No	No	No	7	4
30	1x49	7x50	Shared	15.212	18.8453	Yes	No	No	No	8	9
31	1x50	7x50	Shared	16.5356	20.034	No	Yes	No	No	9	9
32	1x50	2x50	Shared	17.8493	30.3502	No	Yes	No	Yes	9	9
33	2x50	7x49	Shared	20.4469	33.6362	No	Yes	Yes	No	9	9
34	7x45	7x49	Shared	100	99.7708	Yes	No	Yes	No	9	9
35	6x48	7x45	Shared	99.5571	100	Yes	Yes	Yes	No	8	9
36	1x49	7x47	Shared	11.1813	15.2282	Yes	No	No	Yes	8	7
37	1x60	I1x50	Shared	19.9045	24.0501	Yes	No	No	No	6	9
38	2x40	I1x50	Shared	23.7858	24.4407	Yes	Yes	No	No	9	9
39	2x39	2x40	Shared	30.9365	41.5581	No	No	Yes	Yes	8	9
40	2x42	3x49	Shared	77.8662	50.9361	Yes	Yes	Yes	Yes	8	9
41	2x45	4x46	Shared	14.9831	59.0108	No	No	No	Yes	9	8
42	2x45	3x42	Shared	32.8374	63.0142	No	No	No	No	9	8
43	2x46	3x42	Shared	34.0217	63.8124	No	No	No	No	9	8
44	3x40	5x50	Shared	15.6748	27.4549	No	No	No	Yes	7	8
45	3x54	5x64	Shared	19.2874	18.7221	No	No	Yes	No	9	5
46	5x58	6x37	Shared	12.2363	43.4642	Yes	Yes	No	Yes	9	8
47	E2	Lig	Shared	39.9881	38.4929	Yes	Yes	Yes	Yes	4	0
48	3x36	6x48	Shared	12.2363	90.8682	Yes	Yes	Yes	Yes	7	8
49	1x31	NT	cannabinoid_on	0	34.9735	No	No	Yes	Yes	2	4
50	1x31	7x36	cannabinoid_on	0	22.3732	No	No	No	No	2	4
51	1x35	7x36	cannabinoid_on	2.4582	19.2019	No	No	No	No	5	4
52	1x35	7x39	cannabinoid_on	0	16.0221	No	No	No	No	5	5
53	3x36	Lig	cannabinoid_on	9.49443	84.9713	Yes	Yes	Yes	Yes	7	0
54	2x64	Lig	cannabinoid_on	6.53861	24.6614	No	Yes	Yes	Yes	4	0
55	2x64	NT	cannabinoid_on	1.81131	15.3173	No	Yes	Yes	Yes	4	4
56	2x65	Lig	cannabinoid_on	0	16.9136	No	Yes	Yes	Yes	4	0
57	2x65	NT	cannabinoid_on	0	15.831	No	Yes	Yes	Yes	4	4
58	E2	NT	cannabinoid_on	6.20521	20.3142	Yes	Yes	Yes	Yes	4	4
59	1x56	8x53	cannabinoid_on	6.88197	12.2564	No	No	No	No	8	7
60	1x60	8x53	cannabinoid_on	8.28026	13.3093	Yes	No	No	No	6	7
61	2x39	3x49	cannabinoid_on	0	42.5472	No	No	Yes	Yes	8	9
62	2x42	4x46	cannabinoid_on	0	58.0471	Yes	Yes	No	Yes	8	8
63	2x46	7x49	cannabinoid_on	0	94.3536	No	No	Yes	No	9	9
64	2x46	3x43	cannabinoid_on	0	58.6839	No	No	No	No	9	8
65	5x43	Lig	cannabinoid_on	7.44924	14.3069	Yes	Yes	Yes	Yes	6	0
66	3x40	5x51	cannabinoid_on	2.75179	29.238	No	No	No	Yes	7	6
67	5x47	5x51	cannabinoid_on	0	16.8584	No	No	No	Yes	8	6
68	5x43	5x47	cannabinoid_on	1.37341	16.7862	Yes	Yes	No	No	6	8
69	5x51	6x48	cannabinoid_on	0	25.2728	No	Yes	Yes	Yes	6	8
70	3x43	7x53	cannabinoid_on	0	57.7712	No	No	No	Yes	8	9
71	5x58	7x53	cannabinoid_on	0	47.4591	Yes	Yes	No	Yes	9	9
72	3x54	5x61	cannabinoid_on	0	19.7156	No	No	No	No	9	9
73	5x61	6x37	cannabinoid_on	0	20.8661	No	No	No	Yes	9	8
74	1x60	I1x51	cannabinoid_on	0	10.2908	Yes	No	No	No	6	8
75	E2	E3	cannabinoid_on	5.16023	14.3197	Yes	Yes	No	Yes	4	1
76	5x69	6x30	cannabinoid_on	0	10.1167	No	No	Yes	Yes	5	7
77	5x69	6x29	cannabinoid_on	0	11.1738	No	No	No	No	5	6
78	6x29	6x33	cannabinoid_on	0	19.966	No	No	No	No	6	8
79	6x33	6x37	cannabinoid_on	0	22.1354	No	No	No	Yes	8	8
80	6x47	7x45	cannabinoid_on	4.26453	10.2866	No	No	Yes	No	8	9
81	4x56	5x46	cannabinoid_on	6.54857	11.0253	No	No	No	No	5	6
82	5x46	5x50	cannabinoid_on	7.88217	14.7357	No	No	No	Yes	6	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
NT	NT	Shared	35.72	8.69167	1	1	1	1
E1	NT	Shared	16.55	9.90583	1	1	2	1
E2	NT	Shared	25.2225	14.0042	1	1	1	1
2x64	NT	Shared	18.6725	7.84167	1	1	1	1
2x60	NT	cannabinoid_off	5.7075	0	1	0	1	1
3x25	NT	cannabinoid_off	9.7025	0	1	1	2	1
3x28	NT	cannabinoid_off	4.655	0	1	0	2	1
Lig	NT	cannabinoid_off	14.4425	0	1	1	0	1
2x57	NT	cannabinoid_off	3.42	0	1	1	1	1
7x31	NT	Shared	6.445	6.64667	1	1	2	1
7x28	NT	cannabinoid_off	4.43	0	0	0	2	1
7x32	NT	Shared	5.685	3.99167	0	1	2	1
1x28	NT	cannabinoid_off	4.2075	0	1	0	2	1
1x32	NT	Shared	9.64	2.36083	1	1	2	1
1x39	2x61	cannabinoid_off	4.4075	0	0	0	2	1
1x39	7x39	Shared	3.9625	3.18333	0	0	2	1
2x57	7x42	Shared	6.395	3.35	1	1	1	2
2x57	Lig	Shared	11.2675	8.99667	1	1	1	0
2x60	3x28	Shared	3.825	6.7575	1	0	1	2
2x61	2x65	Shared	14.42	9.99417	0	1	1	1
2x64	2x65	Shared	8.77	8.95417	1	1	1	1
3x28	E1	cannabinoid_off	11.06	0	1	0	2	2
3x22	E2	Shared	12.9875	12.8	1	0	2	1
3x25	E2	Shared	14.15	11.5092	1	1	2	1
3x26	E2	Shared	6.945	4.49833	1	1	2	1
3x29	E2	Shared	10.5725	5.235	1	1	1	1
3x29	Lig	Shared	3.995	5.1025	1	1	1	0
3x32	Lig	Shared	10.3725	4.06333	0	1	1	0
3x33	5x43	Shared	7.8825	4.14333	1	1	1	1
3x33	Lig	Shared	3.5	9.98333	1	1	1	0
3x36	6x48	Shared	16.7875	4.00917	1	1	1	1
3x37	5x43	Shared	4.8525	5.45667	0	0	2	1
3x40	5x51	Shared	4.2	3.58417	0	0	2	2
4x59	E2	Shared	5.975	3.9875	1	0	2	1
4x60	E2	cannabinoid_off	4.075	0	1	0	2	1
4x60	5x39	Shared	15.995	9.38583	1	0	2	1
E2	E2	Shared	54.025	45.2975	1	1	1	1
5x36	E2	Shared	16.9075	16.3692	1	1	2	1
5x38	E2	Shared	11.295	5.19583	1	1	2	1
5x39	E2	Shared	13.935	7.58417	1	1	1	1
5x37	E2	Shared	7.7625	7.35833	1	0	2	1
6x58	E2	Shared	10.2525	10.5125	1	0	2	1
E2	E3	Shared	9.3125	12.2742	1	1	1	2
7x31	E2	Shared	6.1375	4.12667	1	1	2	1
6x55	E2	cannabinoid_off	6.26	0	0	0	2	1
7x34	E2	Shared	14.425	10.6167	1	1	1	1
E2	Lig	Shared	16.71	27.3458	1	1	1	0
5x40	E2	Shared	3.7175	6.43083	1	0	2	1
5x36	5x38	Shared	4.5	3.91	1	1	2	2
5x43	5x47	Shared	8.34	10.5367	1	1	1	2
5x43	Lig	Shared	6.3975	9.90333	1	1	1	0
6x44	7x45	cannabinoid_off	4.46	0	1	0	2	2
6x48	7x41	Shared	11.1	5.87833	1	1	1	1
6x48	7x45	Shared	4.2375	4.89667	1	1	1	2
6x48	Lig	cannabinoid_off	5.38	0	1	1	1	0
6x51	7x34	cannabinoid_off	4.355	0	1	0	1	1
6x51	7x41	cannabinoid_off	4.09	0	1	0	1	1
6x51	Lig	cannabinoid_off	3.9175	0	1	0	1	0
6x54	7x34	Shared	5.28	6.7175	0	0	2	1
6x58	E3	cannabinoid_off	4.2725	0	1	0	2	2
7x38	Lig	Shared	9.8825	5.46833	0	1	1	0
7x39	Lig	cannabinoid_off	4.14	0	0	0	1	0
7x41	Lig	cannabinoid_off	4.025	0	1	1	1	0
1x28	1x31	Shared	7.9025	8.50417	1	0	2	2
3x33	4x57	Shared	3.62	3.09167	1	1	1	2
4x59	5x39	cannabinoid_off	4.1025	0	1	0	2	1
6x44	6x48	cannabinoid_off	3.9875	0	1	0	2	1
1x38	7x39	Shared	3.535	3.53333	0	0	2	1
2x64	Lig	Shared	3.415	10.8925	1	1	1	0
3x36	Lig	Shared	5.125	4.3725	1	1	1	0
3x36	3x40	cannabinoid_off	3.2775	0	1	1	1	2
5x42	E2	cannabinoid_off	3.24	0	0	0	2	1
5x43	5x44	cannabinoid_off	3.2125	0	1	1	1	2
1x40	2x61	cannabinoid_off	3.045	0	0	0	2	1
4x63	E2	Shared	2.6025	2.74083	0	0	2	1
3x36	6x52	cannabinoid_off	2.13	0	1	1	1	2
1x35	2x61	cannabinoid_off	1.965	0	0	0	2	1
2x56	3x32	Shared	1.9525	2.34833	0	0	2	1
7x35	NT	cannabinoid_off	1.4425	0	0	0	2	1
1x31	NT	cannabinoid_on	0	4.77	0	1	2	1
2x57	2x61	cannabinoid_on	0	7.9475	1	1	1	1
2x57	7x38	cannabinoid_on	0	3.63167	1	1	1	1
2x60	Lig	cannabinoid_on	0	4.1	1	0	1	0
2x61	Lig	cannabinoid_on	0	3.64083	0	1	1	0
2x65	Lig	cannabinoid_on	0	4.515	0	1	1	0
3x25	E1	cannabinoid_on	0	4.18667	1	1	2	2
3x26	4x60	cannabinoid_on	0	3.83167	1	1	2	2
3x36	7x41	cannabinoid_on	0	7.1	1	1	1	1
5x39	Lig	cannabinoid_on	0	3.63333	1	1	1	0
5x43	6x55	cannabinoid_on	0	3.87667	1	1	1	2
5x44	6x55	cannabinoid_on	0	5.50667	0	0	2	2
5x47	5x51	cannabinoid_on	0	4.27417	0	0	2	2
5x51	6x44	cannabinoid_on	0	3.51417	0	0	2	2
5x51	6x48	cannabinoid_on	0	5.90833	0	0	2	1
7x34	Lig	cannabinoid_on	0	5.075	1	1	1	0
2x65	NT	cannabinoid_on	0	4.74167	0	1	1	1
2x57	3x32	cannabinoid_on	0	4.47833	1	1	1	1
2x64	E1	cannabinoid_on	0	4.61083	1	1	1	2
3x25	3x29	cannabinoid_on	0	4.96667	1	1	2	1
5x39	5x43	cannabinoid_on	0	3.61583	1	1	1	1
6x48	6x51	cannabinoid_on	0	3.1075	1	1	1	1
6x48	6x52	cannabinoid_on	0	3.22667	1	1	1	2
2x57	3x36	cannabinoid_on	0	3.48333	1	1	1	1
3x30	3x33	cannabinoid_on	0	2.88167	0	0	2	1
1x35	7x39	cannabinoid_on	0	2.57667	0	0	2	1
2x53	3x36	cannabinoid_on	0	1.96417	0	0	2	1
2x65	7x35	cannabinoid_on	0	0.975833	0	1	1	2
1x39	1x40	cannabinoid_on	0	0.75	0	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	cannabinoid_off	cb1_off cb2_off
	cannabinoid_on	cb1_on cb2_on

Network Difference
Value	cannabinoid_off	cannabinoid_on
I_min	3.41	2.8875
Number of Linked Nodes	257	265
Number of Specific Nodes	3 (1.17%)	11 (4.15%)
Number of Shared Nodes	254 (98.83%)	254 (95.85%)
Number of Links	283	297
Number of Specific Links	118 (41.70%)	132 (44.44%)
Number of Shared Links	165 (58.30%)	165 (55.56%)
Number of Hubs	24	36
Number of Specific Hubs	9 (37.50%)	21 (58.33%)
Number of Shared Hubs	15 (62.50%)	15 (41.67%)
Average % Shared Neighbours (Jaccard)	43.99
Average % Shared Neighbours (Otsuka)	52.84
Average % Shared Neighbours (Overlap Coefficient)	61.50
Average % Shared Cliques (k3-6)	78.05
Graphlets Similarity	0.556247

Paths Difference
Value	cannabinoid_off	cannabinoid_on
Number Of Nodes in MetaPath	48	51
Specific Nodes in MetaPath	17 (35.42%)	20 (39.22%)
Shared Nodes in MetaPath	254 (98.83%)	254 (98.83%)
Number Of Links MetaPath	48	53
Specific Links in MetaPath	29 (60.42%)	34 (64.15%)
Shared Links in MetaPath	165 (58.30%)	165 (58.30%)
Number of Shortest Paths	37857	46109
Length Of Smallest Path	3	3
Average Path Length	12.5271	13.4814
Length of Longest Path	28	31
Minimum Path Strength	0.5575	0.265417
Average Path Strength	5.63056	5.39166
Maximum Path Strength	21.065	21.8575
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.905334	0.922372
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.34783	3.7037
Average % Of Corr. Nodes	44.3578	46.559
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	41.0653	43.3337
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download cannabinoid_off_on.zip<

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