psnGPCR

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Orange: nodes, hubs and links specific of cb2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cb2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	cb2_off Int. Strength	cb2_on Int. Strength	cb2_off Hub1?	cb2_on Hub1?	cb2_off Hub2?	cb2_on Hub2?	ConSurf1	ConSurf2
1	NT.P20	NT.Y25	cb2_off	6.95	0	Yes	No	No	No	7	4
2	E2.C179	NT.P20	cb2_off	3.77	0	No	No	Yes	No	9	7
3	NT.K23	NT.P21	cb2_off	6.69	0	No	No	No	No	4	4
4	NT.D24	NT.P21	cb2_off	9.66	0	No	No	No	No	4	4
5	NT.D24	NT.K23	cb2_off	6.91	0	No	No	No	No	4	4
6	7x28	NT.I27	cb2_off	7	0	No	No	No	No	3	5
7	1x32	NT.L28	cb2_off	11.28	0	No	Yes	No	No	5	6
8	E1.H98	NT.L28	cb2_off	7.71	0	No	No	No	No	4	6
9	1x28	1x31	cb2_off	7.22	0	No	No	No	No	7	5
10	1x28	7x32	cb2_off	4.59	0	No	No	No	No	7	2
11	1x32	1x33	cb2_off	3	0	No	Yes	No	No	5	4
12	1x35	2x61	cb2_off	3.93	0	No	No	Yes	Yes	5	6
13	1x38	7x39	cb2_off	7.07	0	No	No	No	No	5	5
14	1x43	7x42	cb2_off	3.42	0	No	No	No	No	7	6
15	1x45	1x49	cb2_off	3.98	0	No	No	Yes	No	4	8
16	1x46	7x46	cb2_off	3.26	0	No	No	No	No	7	9
17	8x49	I1x49	cb2_off	5.1	0	Yes	Yes	No	No	6	6
18	8x53	I1x50	cb2_off	3	0	Yes	No	No	No	7	8
19	4x39	I1.R66	cb2_off	8.53	0	No	No	No	No	3	7
20	2x38	I2x53	cb2_off	4.17	0	No	No	Yes	Yes	5	7
21	2x39	2x40	cb2_off	5.09	0	No	No	Yes	Yes	8	8
22	2x39	3x50	cb2_off	5.27	0	No	No	Yes	No	8	9
23	2x40	6x33	cb2_off	5.86	0	Yes	Yes	No	No	8	7
24	2x43	7x53	cb2_off	8.46	0	No	No	Yes	Yes	8	9
25	2x46	2x50	cb2_off	5.43	0	Yes	Yes	Yes	No	9	9
26	2x48	2x52	cb2_off	6.92	0	No	No	No	No	7	7
27	2x49	3x39	cb2_off	3.42	0	No	No	No	No	8	9
28	2x50	3x39	cb2_off	4.42	0	Yes	No	No	No	9	9
29	2x54	7x42	cb2_off	3	0	No	No	No	No	8	6
30	2x63	E1.G99	cb2_off	3.39	0	No	No	No	No	3	5
31	3x22	E2.T173	cb2_off	3	0	No	No	Yes	No	3	5
32	3x24	3x28	cb2_off	3.04	0	No	No	No	No	4	5
33	3x26	E2.T173	cb2_off	4.42	0	No	No	Yes	No	5	5
34	3x29	E2.F183	cb2_off	3.77	0	Yes	No	No	Yes	4	6
35	3x37	4x57	cb2_off	3.2	0	No	No	No	No	6	7
36	3x42	4x49	cb2_off	3.07	0	No	No	No	No	8	6
37	3x48	5x57	cb2_off	3.04	0	No	No	No	No	6	6
38	3x49	3x50	cb2_off	4.76	0	Yes	Yes	Yes	No	9	9
39	3x50	6x30	cb2_off	3.57	0	Yes	No	No	Yes	9	7
40	3x50	6x33	cb2_off	8.5	0	Yes	No	No	No	9	7
41	3x53	6x30	cb2_off	6.22	0	No	No	No	Yes	8	7
42	3x54	5x68	cb2_off	7.71	0	No	No	Yes	No	9	7
43	I2x53	I2x57	cb2_off	14.07	0	Yes	Yes	No	No	7	6
44	I2x56	I2x57	cb2_off	4.15	0	No	No	No	No	4	6
45	4x59	5x39	cb2_off	5.86	0	No	No	Yes	Yes	5	7
46	4x60	E2.I186	cb2_off	3.39	0	No	No	Yes	Yes	5	5
47	5x38	E2.W172	cb2_off	10.05	0	No	No	Yes	Yes	4	5
48	5x36	E2.R177	cb2_off	4.32	0	Yes	Yes	Yes	No	4	3
49	E2.I186	E2.S180	cb2_off	3.1	0	Yes	Yes	No	No	5	4
50	5x36	5x38	cb2_off	3.22	0	Yes	Yes	No	No	4	4
51	5x39	Lig	cb2_off	3.29	0	Yes	Yes	Yes	Yes	7	0
52	5x40	6x59	cb2_off	6.92	0	No	No	No	No	5	3
53	5x51	6x45	cb2_off	4.87	0	No	Yes	No	No	7	6
54	5x58	5x61	cb2_off	5.05	0	Yes	Yes	No	No	9	9
55	5x58	5x62	cb2_off	10.55	0	Yes	Yes	No	No	9	6
56	5x58	6x38	cb2_off	5.79	0	Yes	Yes	No	No	9	6
57	5x60	5x63	cb2_off	3.17	0	No	No	No	No	5	3
58	5x63	5x64	cb2_off	3.48	0	No	No	No	No	3	6
59	5x68	I3.R236	cb2_off	9.03	0	Yes	No	No	No	7	3
60	5x68	6x31	cb2_off	4.15	0	Yes	No	No	No	7	5
61	5x69	I3.A235	cb2_off	3.39	0	No	No	No	No	5	1
62	6x28	6x29	cb2_off	3.64	0	Yes	No	Yes	No	4	5
63	6x28	8x48	cb2_off	8.14	0	Yes	No	No	No	4	4
64	6x29	6x32	cb2_off	5.3	0	Yes	No	No	No	5	8
65	6x29	8x48	cb2_off	5.3	0	Yes	No	No	No	5	4
66	6x29	8x49	cb2_off	5.3	0	Yes	No	Yes	Yes	5	6
67	6x32	8x48	cb2_off	10.15	0	No	No	No	No	8	4
68	6x35	7x56	cb2_off	4.95	0	No	No	No	No	7	7
69	6x40	7x49	cb2_off	5.91	0	No	No	No	No	8	9
70	6x43	7x48	cb2_off	6.41	0	No	No	No	No	7	6
71	6x44	7x45	cb2_off	5.49	0	No	No	No	No	9	9
72	6x47	7x43	cb2_off	3.27	0	No	No	No	No	8	4
73	6x48	6x52	cb2_off	3.42	0	Yes	Yes	No	No	8	6
74	6x48	Lig	cb2_off	7.98	0	Yes	Yes	Yes	Yes	8	0
75	6x51	7x41	cb2_off	3.42	0	No	No	No	No	6	7
76	6x51	Lig	cb2_off	3.13	0	No	No	Yes	Yes	6	0
77	6x55	Lig	cb2_off	5.95	0	No	Yes	Yes	Yes	6	0
78	6x58	E3.L273	cb2_off	3	0	No	No	Yes	No	3	1
79	7x27	7x29	cb2_off	5.78	0	No	No	No	No	2	3
80	7x41	Lig	cb2_off	3.34	0	No	No	Yes	Yes	7	0
81	7x53	8x50	cb2_off	3.63	0	Yes	Yes	Yes	No	9	8
82	8x50	8x53	cb2_off	3.1	0	Yes	No	Yes	No	8	7
83	1x57	2x43	cb2_off	2.94	0	No	No	No	No	8	8
84	7x29	7x30	cb2_off	2.87	0	No	No	No	No	3	3
85	3x48	3x52	cb2_off	2.85	0	No	No	No	No	6	5
86	4x48	4x52	cb2_off	2.85	0	No	No	No	No	3	4
87	5x54	6x41	cb2_off	2.85	0	No	No	No	No	8	7
88	3x50	6x34	cb2_off	2.77	0	Yes	No	No	No	9	8
89	3x52	I2x56	cb2_off	2.77	0	No	No	No	No	5	4
90	5x68	I3.M237	cb2_off	2.63	0	Yes	No	No	No	7	4
91	6x36	7x53	cb2_off	2.5	0	No	No	Yes	Yes	8	9
92	5x42	E2.W172	cb2_off	2.47	0	No	No	Yes	Yes	5	5
93	2x51	2x52	cb2_off	2.44	0	Yes	Yes	No	No	7	7
94	3x25	E1.D101	cb2_off	2.39	0	Yes	Yes	No	No	9	2
95	2x48	4x50	cb2_off	2.28	0	No	No	No	Yes	7	9
96	NT.P20	NT.P21	cb2_off	1.95	0	Yes	No	No	No	7	4
97	6x50	7x37	cb2_off	1.88	0	No	No	No	No	9	4
98	NT.A19	NT.P20	cb2_off	1.87	0	No	No	Yes	No	5	7
99	1x53	7x50	cb2_off	1.77	0	No	No	No	No	9	9
100	E1.G99	NT.M26	cb2_off	1.75	0	No	No	No	No	5	6
101	4x60	E2.T173	cb2_off	1.75	0	No	No	Yes	No	5	5
102	1x59	8x57	cb2_off	1.72	0	No	No	No	No	5	6
103	1x60	8x57	cb2_off	1.72	0	No	No	No	No	7	6
104	6x43	6x47	cb2_off	1.71	0	No	No	No	No	7	8
105	5x65	6x31	cb2_off	1.7	0	No	No	No	No	8	5
106	3x46	6x37	cb2_off	1.58	0	No	No	No	No	9	8
107	3x47	6x37	cb2_off	1.58	0	No	No	No	No	9	8
108	6x28	I3.A235	cb2_off	1.38	0	Yes	No	No	No	4	1
109	I1x48	I1x49	cb2_off	1.24	0	No	No	No	No	5	6
110	5x45	5x49	cb2_off	1.22	0	No	No	No	No	3	4
111	2x41	4x39	cb2_off	1.21	0	No	No	No	No	4	3
112	I1.R66	I1x51	cb2_off	1.07	0	No	No	No	No	7	3
113	3x25	NT.M22	Shared	12.44	3.31833	Yes	Yes	No	Yes	9	7
114	E2.P184	NT.Y25	Shared	23.64	14.6017	No	No	No	No	5	4
115	2x64	NT.M26	Shared	9.95	6.01167	Yes	Yes	No	No	3	6
116	E1.H98	NT.M26	Shared	7.88	4.59667	No	No	No	No	4	6
117	7x31	NT.I27	Shared	4.36	7.27	No	No	No	No	2	5
118	7x32	NT.I27	Shared	4.36	2.90833	No	No	No	No	2	5
119	1x29	1x30	Shared	4.06	4.06	No	No	No	No	4	4
120	1x29	1x32	Shared	5.23	2.32333	No	No	No	Yes	4	5
121	1x35	7x36	Shared	3.93	2.62	No	No	No	No	5	4
122	1x36	2x66	Shared	3.39	3.95833	No	No	No	Yes	5	4
123	1x38	1x42	Shared	5.54	3.69	No	No	No	Yes	5	6
124	1x39	2x61	Shared	4.19	3.26	No	No	Yes	Yes	6	6
125	1x39	7x39	Shared	4.86	4.32	No	No	No	No	6	5
126	1x45	7x47	Shared	4.24	4.475	No	No	No	Yes	4	6
127	1x46	2x54	Shared	6.52	5.43333	No	No	No	No	7	8
128	1x46	7x47	Shared	3.07	4.09	No	No	No	Yes	7	6
129	1x49	7x47	Shared	6.77	3.15667	Yes	No	No	Yes	8	6
130	1x49	7x50	Shared	7.86	5.5	Yes	No	No	No	8	9
131	1x50	2x50	Shared	6.73	11.22	No	No	Yes	No	9	9
132	1x50	7x50	Shared	4.89	5.97667	No	No	No	No	9	9
133	1x53	2x47	Shared	3.39	2.545	No	No	No	No	9	9
134	1x54	2x47	Shared	3.15	2.10333	No	No	No	No	7	9
135	1x55	1x59	Shared	11.45	11.2333	No	No	No	No	5	5
136	1x55	8x61	Shared	4.82	2.25	No	No	No	No	5	3
137	1x56	8x53	Shared	4.5	3.00167	No	No	Yes	No	8	7
138	1x56	8x54	Shared	3.15	2.62667	No	No	No	No	8	6
139	1x60	I1x50	Shared	6.01	8.76	No	No	No	No	7	8
140	1x60	8x53	Shared	4.89	2.71667	No	No	Yes	No	7	7
141	2x40	I1x50	Shared	10.55	6.83833	Yes	Yes	No	No	8	8
142	2x37	2x40	Shared	4.78	8.75833	No	No	Yes	Yes	6	8
143	2x37	8x49	Shared	6.75	4.275	No	No	Yes	Yes	6	6
144	2x40	2x43	Shared	3.63	2.01667	Yes	Yes	No	No	8	8
145	2x40	8x47	Shared	3.82	8.05333	Yes	Yes	No	No	8	8
146	2x40	8x49	Shared	15.71	9.165	Yes	Yes	Yes	Yes	8	6
147	2x40	8x50	Shared	4.84	5.23833	Yes	Yes	Yes	No	8	8
148	2x42	3x49	Shared	9.55	4.77667	No	Yes	Yes	Yes	8	9
149	2x42	4x46	Shared	3.65	3.855	No	Yes	No	Yes	8	8
150	2x45	3x42	Shared	4.89	4.34667	No	No	No	No	9	8
151	2x45	4x46	Shared	9.01	9.01	No	No	No	Yes	9	8
152	2x45	4x50	Shared	6.18	4.53333	No	No	No	Yes	9	9
153	2x46	3x39	Shared	3	1.5	Yes	Yes	No	No	9	9
154	2x46	7x49	Shared	4.12	3.66167	Yes	Yes	No	No	9	9
155	2x50	7x46	Shared	7.36	8.34333	Yes	No	No	No	9	9
156	2x51	2x55	Shared	3.93	3.93167	Yes	Yes	No	No	7	4
157	2x53	3x35	Shared	3.36	3.63833	No	No	No	No	8	7
158	2x57	2x61	Shared	3.22	5.535	No	Yes	Yes	Yes	6	6
159	2x57	Lig	Shared	10.25	9.48333	No	Yes	Yes	Yes	6	0
160	2x60	Lig	Shared	3.16	3.76	No	No	Yes	Yes	4	0
161	2x61	2x65	Shared	12.44	13.1983	Yes	Yes	No	Yes	6	4
162	2x61	Lig	Shared	3.42	3.82167	Yes	Yes	Yes	Yes	6	0
163	2x62	2x66	Shared	4.81	3.205	No	No	No	Yes	5	4
164	2x64	2x65	Shared	6.79	7.35167	Yes	Yes	No	Yes	3	4
165	2x64	3x25	Shared	3.22	3.93	Yes	Yes	Yes	Yes	3	9
166	2x64	Lig	Shared	6.83	10.785	Yes	Yes	Yes	Yes	3	0
167	2x66	E1.F97	Shared	5.24	2.185	No	Yes	No	No	4	3
168	3x24	E1.D101	Shared	5.84	2.43333	No	No	No	No	4	2
169	3x28	E1.D101	Shared	12.44	3.91833	No	No	No	No	5	2
170	3x21	3x24	Shared	3.23	4.31167	No	No	No	No	6	4
171	3x22	E2.L185	Shared	5.64	4.23	No	No	No	No	3	4
172	3x25	3x29	Shared	3.77	6.28	Yes	Yes	Yes	No	9	4
173	3x25	E2.P184	Shared	8.67	5.05333	Yes	Yes	No	No	9	5
174	3x29	E2.I186	Shared	5.89	3.435	Yes	No	Yes	Yes	4	5
175	3x29	Lig	Shared	5	6.56833	Yes	No	Yes	Yes	4	0
176	3x30	4x58	Shared	4.35	2.9	No	No	No	Yes	6	4
177	3x31	4x58	Shared	5.09	3.81833	No	No	No	Yes	4	4
178	3x32	Lig	Shared	5.22	3.88	No	No	Yes	Yes	5	0
179	3x33	4x57	Shared	6.4	5.06333	No	No	No	No	4	7
180	3x33	5x43	Shared	4.85	4.64667	No	No	Yes	Yes	4	5
181	3x33	Lig	Shared	5.17	10.95	No	No	Yes	Yes	4	0
182	3x34	4x54	Shared	3.22	1.87833	No	Yes	No	No	5	3
183	3x34	4x57	Shared	4.6	5.11	No	Yes	No	No	5	7
184	3x34	4x58	Shared	5.99	9.38	No	Yes	No	Yes	5	4
185	3x36	6x48	Shared	4.01	7.685	No	Yes	Yes	Yes	6	8
186	3x36	Lig	Shared	10.25	3.995	No	Yes	Yes	Yes	6	0
187	3x37	4x53	Shared	4.8	3.73333	No	No	No	No	6	8
188	3x37	5x43	Shared	3.64	6.06333	No	No	Yes	Yes	6	5
189	3x38	4x50	Shared	7.78	7.34667	No	No	No	Yes	7	9
190	3x38	4x53	Shared	3.42	3.42	No	No	No	No	7	8
191	3x40	5x50	Shared	5.96	3.97333	No	No	No	Yes	8	7
192	3x40	5x51	Shared	3.93	5.67833	No	No	No	Yes	8	7
193	3x41	4x49	Shared	3.49	4.075	No	No	No	No	5	6
194	3x44	5x54	Shared	5.71	4.04333	No	Yes	No	No	6	8
195	3x45	4x49	Shared	4.24	5.18167	No	No	No	No	6	6
196	3x49	I2x53	Shared	8.05	9.96167	Yes	Yes	Yes	Yes	9	7
197	3x49	I2x57	Shared	5.43	6.335	Yes	Yes	No	No	9	6
198	3x51	3x55	Shared	13.38	11.8333	No	No	No	No	8	6
199	3x53	I2x53	Shared	4.03	8.06333	No	No	Yes	Yes	8	7
200	3x55	3x56	Shared	19.55	20.5767	No	No	No	Yes	6	5
201	I2x50	I2x51	Shared	5.84	7.465	No	No	No	No	8	7
202	4x38	4x41	Shared	11.64	4.74167	No	No	No	No	9	6
203	4x56	5x46	Shared	5.24	7.64833	No	No	No	No	5	5
204	4x59	E2.W172	Shared	5.69	4.175	No	No	Yes	Yes	5	5
205	4x60	5x39	Shared	12.52	12.285	No	No	Yes	Yes	5	7
206	E2.R177	E2.W172	Shared	8	2.33167	Yes	No	Yes	Yes	3	5
207	5x39	E2.W172	Shared	9.65	4.66167	Yes	Yes	Yes	Yes	7	5
208	E2.C174	E2.C179	Shared	7.28	7.28	No	No	No	No	5	9
209	5x36	E2.C174	Shared	5.65	4.08	Yes	Yes	No	No	4	5
210	E2.C175	E2.P176	Shared	3.77	2.82167	No	No	No	No	3	4
211	5x38	E2.R177	Shared	10.72	6.35333	No	No	Yes	No	4	3
212	5x37	E2.S180	Shared	4.47	3.22833	No	No	No	No	4	4
213	E2.E181	E3.L273	Shared	5.3	5.52167	No	No	Yes	No	4	1
214	7x31	E2.E181	Shared	9.45	4.05	No	No	No	No	2	4
215	E2.F183	E2.L182	Shared	3.65	4.265	No	Yes	No	No	6	4
216	6x58	E2.L182	Shared	4.5	7.50833	No	No	No	No	3	4
217	7x34	E2.L182	Shared	14.61	9.135	No	Yes	No	No	4	4
218	E2.F183	Lig	Shared	21.35	26.845	No	Yes	Yes	Yes	6	0
219	5x36	E2.I186	Shared	3.39	3.95333	Yes	Yes	Yes	Yes	4	5
220	E2.I186	Lig	Shared	5	3.33667	Yes	Yes	Yes	Yes	5	0
221	5x37	6x59	Shared	5.49	3.43333	No	No	No	No	4	3
222	5x41	6x59	Shared	4.15	5.075	No	No	No	No	4	3
223	5x43	5x47	Shared	10.57	11.7433	Yes	Yes	No	No	5	7
224	5x43	Lig	Shared	10.38	13.5033	Yes	Yes	Yes	Yes	5	0
225	5x46	5x50	Shared	10.96	5.48167	No	No	No	Yes	5	7
226	5x56	5x60	Shared	15.24	8.71167	No	No	No	No	4	5
227	5x58	6x37	Shared	3.52	9.965	Yes	Yes	No	No	9	8
228	5x58	6x41	Shared	3.52	7.23	Yes	Yes	No	No	9	7
229	5x63	5x67	Shared	4.38	5.84333	No	No	No	No	3	5
230	5x64	5x67	Shared	6.78	3.39167	No	No	No	No	6	5
231	6x30	I3.M237	Shared	5.54	2.30833	No	Yes	No	No	7	4
232	6x28	6x32	Shared	3.49	2.31	Yes	No	No	No	4	8
233	6x36	7x56	Shared	9.06	12.7183	No	No	No	No	8	7
234	6x39	7x56	Shared	6.07	4.65667	No	No	No	No	6	7
235	6x40	7x53	Shared	3.79	7.57	No	No	Yes	Yes	8	9
236	6x44	6x48	Shared	4.56	3.23	No	No	Yes	Yes	9	8
237	6x47	7x45	Shared	7.87	7.87167	No	No	No	No	8	9
238	6x48	7x41	Shared	3.92	7.40333	Yes	Yes	No	No	8	7
239	6x49	6x50	Shared	4.33	3.12667	No	No	No	No	5	9
240	6x54	7x34	Shared	3.65	5.48167	No	No	No	Yes	4	4
241	6x54	7x37	Shared	3.17	1.58667	No	No	No	No	4	4
242	6x57	6x61	Shared	6.85	3.19667	No	No	No	No	4	3
243	7x38	Lig	Shared	3.16	7.32	No	No	Yes	Yes	5	0
244	7x48	7x52	Shared	3.07	4.09667	No	No	No	Yes	6	9
245	7x55	8x51	Shared	3.64	1.01167	No	No	No	No	6	8
246	8x47	8x50	Shared	9.29	5.67333	No	No	Yes	No	8	8
247	7x30	E3.L273	Shared	2.98	3.725	No	No	Yes	No	3	1
248	2x52	3x35	Shared	2.95	3.685	No	No	No	No	7	7
249	E2.P178	E2.R177	Shared	2.88	3.6	No	No	Yes	No	4	3
250	3x44	3x48	Shared	2.85	3.33	No	Yes	No	No	6	6
251	5x55	6x41	Shared	2.85	3.32833	No	No	No	No	5	7
252	5x44	6x55	Shared	2.83	5.18	No	No	No	Yes	4	6
253	8x58	8x62	Shared	2.82	2.115	No	No	No	No	6	4
254	1x44	1x48	Shared	2.77	1.15167	No	No	No	No	5	4
255	1x47	2x51	Shared	2.77	3.00167	No	No	Yes	Yes	6	7
256	2x42	4x42	Shared	2.77	2.77167	No	Yes	No	No	8	7
257	2x46	3x43	Shared	2.77	5.07667	Yes	Yes	No	No	9	8
258	3x26	4x61	Shared	2.77	3.22667	No	No	No	Yes	5	6
259	3x43	6x44	Shared	2.77	2.99667	No	No	No	No	8	9
260	5x41	5x45	Shared	2.77	1.845	No	No	No	No	4	3
261	6x49	6x53	Shared	2.77	2.77167	No	No	No	No	5	5
262	1x51	2x51	Shared	2.62	4.58833	No	No	Yes	Yes	5	7
263	6x57	E3.L273	Shared	2.57	2.785	No	No	Yes	No	4	1
264	5x47	5x51	Shared	2.51	4.605	No	No	No	Yes	7	7
265	3x51	5x57	Shared	2.5	3.33	No	No	No	No	8	6
266	3x55	5x64	Shared	2.48	5.36167	No	No	No	No	6	6
267	1x43	2x58	Shared	1.95	1.3	No	No	No	No	7	6
268	2x44	2x47	Shared	1.95	1.95	No	No	No	No	7	9
269	2x55	2x59	Shared	1.71	0.57	No	No	No	No	4	7
270	E2.C175	E2.T173	Shared	1.69	3.38	No	No	Yes	No	3	5
271	6x60	6x61	Shared	1.68	0.84	No	No	No	No	4	3
272	6x50	7x40	Shared	1.64	2.18667	No	No	No	No	9	8
273	2x56	3x31	Shared	1.62	3.23167	No	No	No	No	4	4
274	1x37	1x41	Shared	1.49	0.745	No	No	No	No	5	4
275	7x51	7x55	Shared	1.49	2.48333	No	No	No	No	6	6
276	2x65	7x35	Shared	1.46	1.465	No	Yes	No	No	4	4
277	1x49	7x51	Shared	1.43	1.90167	Yes	No	No	No	8	6
278	4x45	4x48	Shared	1.43	1.52	No	No	No	No	6	3
279	4x61	4x62	Shared	1.41	2.59	No	Yes	No	No	6	4
280	E2.E181	E3.T272	Shared	1.41	4.23333	No	No	No	No	4	1
281	2x41	4x43	Shared	1.38	3.46	No	No	No	No	4	1
282	3x27	4x61	Shared	1.38	2.76667	No	No	No	Yes	4	6
283	3x56	I2x52	Shared	1.27	2.33	No	Yes	No	No	5	5
284	I1.R66	I1x48	Shared	1.13	1.88167	No	No	No	No	7	5
285	4x39	I1x51	Shared	1.07	2.84333	No	No	No	No	3	3
286	NT.M22	NT.Y25	cb2_on	0	3.19167	No	Yes	No	No	7	4
287	2x64	NT.M22	cb2_on	0	3.11167	Yes	Yes	No	Yes	3	7
288	2x65	NT.L28	cb2_on	0	3.85667	No	Yes	No	No	4	6
289	1x28	1x32	cb2_on	0	3.06	No	No	No	Yes	7	5
290	1x31	7x36	cb2_on	0	8.785	No	No	No	No	5	4
291	1x32	E1.H98	cb2_on	0	3.71167	No	Yes	No	No	5	4
292	1x42	7x42	cb2_on	0	3.23	No	Yes	No	No	6	6
293	1x42	7x43	cb2_on	0	3.33	No	Yes	No	No	6	4
294	1x42	7x47	cb2_on	0	4.71	No	Yes	No	Yes	6	6
295	1x50	2x51	cb2_on	0	4.63167	No	No	Yes	Yes	9	7
296	8x49	I1x50	cb2_on	0	4.42	Yes	Yes	No	No	6	8
297	2x38	I2x57	cb2_on	0	4.10333	No	No	No	No	5	6
298	2x39	3x49	cb2_on	0	6.13667	No	No	Yes	Yes	8	9
299	2x42	3x45	cb2_on	0	9.54	No	Yes	No	No	8	6
300	2x46	3x42	cb2_on	0	5.50667	Yes	Yes	No	No	9	8
301	2x46	7x53	cb2_on	0	4.10333	Yes	Yes	Yes	Yes	9	9
302	2x50	7x49	cb2_on	0	3.81333	Yes	No	No	No	9	9
303	2x53	3x36	cb2_on	0	3.92833	No	No	No	Yes	8	6
304	2x57	3x32	cb2_on	0	4.58667	No	Yes	No	No	6	5
305	2x57	3x36	cb2_on	0	4.82333	No	Yes	No	Yes	6	6
306	2x57	7x38	cb2_on	0	4.62333	No	Yes	No	No	6	5
307	2x57	7x42	cb2_on	0	5.88667	No	Yes	No	No	6	6
308	2x60	3x28	cb2_on	0	5.865	No	No	No	No	4	5
309	3x34	4x50	cb2_on	0	3.10333	No	Yes	No	Yes	5	9
310	3x36	7x41	cb2_on	0	5.35333	No	Yes	No	No	6	7
311	3x37	5x47	cb2_on	0	3.29333	No	No	No	No	6	7
312	3x40	6x48	cb2_on	0	3.065	No	No	Yes	Yes	8	8
313	3x43	7x53	cb2_on	0	7.425	No	No	Yes	Yes	8	9
314	3x45	4x45	cb2_on	0	3.68333	No	No	No	No	6	6
315	3x46	7x53	cb2_on	0	4.37	No	No	Yes	Yes	9	9
316	3x47	5x57	cb2_on	0	3.35833	No	No	No	No	9	6
317	3x47	5x58	cb2_on	0	7.11667	No	No	Yes	Yes	9	9
318	3x50	5x58	cb2_on	0	6.17167	Yes	No	Yes	Yes	9	9
319	3x50	7x53	cb2_on	0	8.40333	Yes	No	Yes	Yes	9	9
320	3x51	5x60	cb2_on	0	7.62167	No	No	No	No	8	5
321	3x54	5x61	cb2_on	0	3.47667	No	No	No	No	9	9
322	3x56	I2x56	cb2_on	0	3.125	No	Yes	No	No	5	4
323	I2x53	I2x54	cb2_on	0	4.18	Yes	Yes	No	No	7	5
324	4x46	4x50	cb2_on	0	4.555	No	Yes	No	Yes	8	9
325	5x36	E2.W172	cb2_on	0	8.33167	Yes	Yes	Yes	Yes	4	5
326	5x40	E2.S180	cb2_on	0	3	No	No	No	No	5	4
327	E2.F183	E2.I186	cb2_on	0	3.76833	No	Yes	Yes	Yes	6	5
328	6x55	E2.F183	cb2_on	0	4.56167	No	Yes	No	Yes	6	6
329	7x34	E2.F183	cb2_on	0	5.895	No	Yes	No	Yes	4	6
330	E2.P184	Lig	cb2_on	0	4.84	No	No	Yes	Yes	5	0
331	5x39	E2.I186	cb2_on	0	3.42667	Yes	Yes	Yes	Yes	7	5
332	5x36	5x39	cb2_on	0	3.01167	Yes	Yes	Yes	Yes	4	7
333	5x39	5x43	cb2_on	0	4.98167	Yes	Yes	Yes	Yes	7	5
334	5x40	6x55	cb2_on	0	3.53333	No	No	No	Yes	5	6
335	5x43	6x55	cb2_on	0	3.87667	Yes	Yes	No	Yes	5	6
336	5x51	6x44	cb2_on	0	4.26167	No	Yes	No	No	7	9
337	5x51	6x48	cb2_on	0	8.01667	No	Yes	Yes	Yes	7	8
338	5x58	6x40	cb2_on	0	3.57667	Yes	Yes	No	No	9	8
339	5x58	7x53	cb2_on	0	3.47333	Yes	Yes	Yes	Yes	9	9
340	5x61	6x37	cb2_on	0	2.98	No	No	No	No	9	8
341	5x62	6x37	cb2_on	0	3.69	No	No	No	No	6	8
342	5x66	6x30	cb2_on	0	7.56	No	No	No	Yes	5	7
343	5x69	6x29	cb2_on	0	3.725	No	No	Yes	No	5	5
344	5x69	6x30	cb2_on	0	8.52	No	No	No	Yes	5	7
345	6x43	7x52	cb2_on	0	3.84167	No	No	No	Yes	7	9
346	6x48	7x45	cb2_on	0	6.40333	Yes	Yes	No	No	8	9
347	7x29	7x32	cb2_on	0	10.8483	No	No	No	No	3	2
348	7x34	Lig	cb2_on	0	6.41	No	Yes	Yes	Yes	4	0
349	7x45	7x49	cb2_on	0	8.40167	No	No	No	No	9	9
350	8x48	8x51	cb2_on	0	5.00333	No	No	No	No	4	8
351	1x31	NT.L28	cb2_on	0	3.32667	No	No	No	No	5	6
352	7x32	NT.L28	cb2_on	0	3.525	No	No	No	No	2	6
353	1x54	2x48	cb2_on	0	3.135	No	No	No	No	7	7
354	I1.R66	I1x49	cb2_on	0	4.09	No	No	No	No	7	6
355	6x31	6x35	cb2_on	0	3.28833	No	No	No	No	5	7
356	8x60	8x61	cb2_on	0	4.585	No	No	No	No	5	3
357	2x61	7x39	cb2_on	0	3.52333	Yes	Yes	No	No	6	5
358	3x46	3x50	cb2_on	0	3.44833	No	No	Yes	No	9	9
359	2x41	4x42	cb2_on	0	2.89167	No	No	No	No	4	7
360	6x39	7x52	cb2_on	0	2.855	No	No	No	Yes	6	9
361	6x51	7x34	cb2_on	0	2.83833	No	No	No	Yes	6	4
362	1x53	7x54	cb2_on	0	2.82833	No	No	No	No	9	8
363	7x52	7x53	cb2_on	0	2.82167	No	Yes	Yes	Yes	9	9
364	1x53	1x57	cb2_on	0	2.815	No	No	No	No	9	8
365	2x49	4x50	cb2_on	0	2.80667	No	No	No	Yes	8	9
366	2x37	2x38	cb2_on	0	2.79	No	No	No	No	6	5
367	3x44	5x50	cb2_on	0	2.76667	No	Yes	No	Yes	6	7
368	4x58	4x61	cb2_on	0	2.73333	No	Yes	No	Yes	4	6
369	7x28	7x30	cb2_on	0	2.67833	No	No	No	No	3	3
370	6x47	7x40	cb2_on	0	2.645	No	No	No	No	8	8
371	3x25	E2.L185	cb2_on	0	2.63833	Yes	Yes	No	No	9	4
372	5x51	6x52	cb2_on	0	2.63833	No	Yes	No	No	7	6
373	1x60	I1x49	cb2_on	0	2.405	No	No	No	No	7	6
374	1x56	8x57	cb2_on	0	2.37833	No	No	No	No	8	6
375	I3.H226	I3.Q227	cb2_on	0	2.26833	No	No	No	No	0	0
376	7x54	8x50	cb2_on	0	2.16333	No	No	Yes	No	8	8
377	5x68	6x29	cb2_on	0	2.14167	Yes	No	Yes	No	7	5
378	I3.Q227	I3.Q230	cb2_on	0	2.13333	No	No	No	No	0	0
379	5x62	6x34	cb2_on	0	2.10333	No	No	No	No	6	8
380	6x29	6x33	cb2_on	0	2.07667	Yes	No	No	No	5	7
381	3x54	6x33	cb2_on	0	2.075	No	No	No	No	9	7
382	4x39	4x43	cb2_on	0	2.02333	No	No	No	No	3	1
383	2x63	E1.F97	cb2_on	0	2.01333	No	No	No	No	3	3
384	8x60	8x63	cb2_on	0	1.965	No	No	No	No	5	2
385	E1.H98	NT.K23	cb2_on	0	1.965	No	No	No	No	4	4
386	6x28	6x31	cb2_on	0	1.96333	Yes	No	No	No	4	5
387	3x52	3x56	cb2_on	0	1.95	No	No	No	Yes	5	5
388	3x52	I2x53	cb2_on	0	1.95	No	No	Yes	Yes	5	7
389	NT.D24	NT.Y25	cb2_on	0	1.91667	No	No	No	No	4	4
390	I1x48	I1x51	cb2_on	0	1.88167	No	No	No	No	5	3
391	6x28	6x30	cb2_on	0	1.78667	Yes	No	No	Yes	4	7
392	1x32	2x66	cb2_on	0	1.77167	No	Yes	No	Yes	5	4
393	4x39	4x40	cb2_on	0	1.75	No	No	No	No	3	4
394	4x52	5x46	cb2_on	0	1.625	No	No	No	No	4	5
395	1x58	I1x51	cb2_on	0	1.61833	No	No	No	No	4	3
396	3x54	5x65	cb2_on	0	1.58	No	No	No	No	9	8
397	5x65	6x33	cb2_on	0	1.58	No	No	No	No	8	7
398	E2.P176	E2.W172	cb2_on	0	1.57667	No	No	Yes	Yes	4	5
399	1x43	1x46	cb2_on	0	1.55	No	No	No	No	7	7
400	3x44	5x53	cb2_on	0	1.425	No	Yes	No	No	6	5
401	6x45	6x49	cb2_on	0	1.42	No	No	No	No	6	5
402	E1.D101	E1.G99	cb2_on	0	1.39667	No	No	No	No	2	5
403	3x56	I2x50	cb2_on	0	1.39	No	Yes	No	No	5	8
404	5x44	6x56	cb2_on	0	1.31667	No	No	No	No	4	5
405	5x49	5x50	cb2_on	0	1.22	No	No	No	Yes	4	7
406	4x62	4x63	cb2_on	0	1.16667	No	No	No	No	4	4
407	3x21	3x23	cb2_on	0	1.14	No	No	No	No	6	1
408	I3.M234	I3.Q230	cb2_on	0	1.13333	No	No	No	No	0	0
409	8x51	8x55	cb2_on	0	1.13	No	No	No	No	8	4
410	1x55	8x57	cb2_on	0	1.12	No	No	No	No	5	6
411	NT.M22	NT.P21	cb2_on	0	1.11833	No	Yes	No	No	7	4
412	5x72	I3.Q227	cb2_on	0	1.10833	No	No	No	No	0	0
413	7x27	E3.T272	cb2_on	0	1.06667	No	No	No	No	2	1
414	5x39	5x42	cb2_on	0	1.06	Yes	Yes	No	No	7	5
415	4x38	4x40	cb2_on	0	0.91	No	No	No	No	9	4
416	5x68	5x72	cb2_on	0	0.858333	Yes	No	No	No	7	0
417	4x46	4x47	cb2_on	0	0.855	No	Yes	No	No	8	4
418	1x40	2x62	cb2_on	0	0.795	No	No	No	No	5	5
419	4x44	4x48	cb2_on	0	0.77	No	No	No	No	3	3
420	4x55	4x56	cb2_on	0	0.745	No	No	No	No	3	5
421	8x49	8x52	cb2_on	0	0.72	Yes	Yes	No	No	6	4
422	8x52	8x56	cb2_on	0	0.696667	No	No	No	No	4	5
423	1x41	1x42	cb2_on	0	0.691667	No	No	No	Yes	4	6
424	I3.P232	I3.V231	cb2_on	0	0.588333	No	No	No	No	0	0
425	5x70	5x73	cb2_on	0	0.57	No	No	No	Yes	5	0
426	1x33	1x34	cb2_on	0	0.56	No	No	No	No	4	5
427	6x46	6x47	cb2_on	0	0.546667	No	No	No	No	5	8
428	5x69	5x73	cb2_on	0	0.54	No	No	No	Yes	5	0
429	E1.V100	NT.M22	cb2_on	0	0.506667	No	No	No	Yes	4	7
430	5x71	I3.H226	cb2_on	0	0.465	No	No	No	No	3	0
431	1x34	7x36	cb2_on	0	0.461667	No	No	No	No	5	4
432	1x45	1x48	cb2_on	0	0.46	No	No	No	No	4	4
433	8x55	8x58	cb2_on	0	0.428333	No	No	No	No	4	6
434	5x52	5x53	cb2_on	0	0.31	No	No	No	No	3	5
435	5x73	5x74	cb2_on	0	0.31	No	Yes	No	No	0	0
436	6x42	6x46	cb2_on	0	0.27	No	No	No	No	5	5
437	5x73	I3.V231	cb2_on	0	0.27	No	Yes	No	No	0	0
438	7x29	7x33	cb2_on	0	0.253333	No	No	No	No	3	3
439	I3.P232	I3.R229	cb2_on	0	0.24	No	No	No	No	0	0
440	I3.D228	I3.R229	cb2_on	0	0.198333	No	No	No	No	0	0

Orange: nodes, hubs and links specific of cb2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cb2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	cb2_off Avg Int. Strength	cb2_on Avg Int. Strength	cb2_off Num Of Links	cb2_on Num Of Links	ConSurf
1	NT.P20	cb2_off	3.635	0	4	0	7
2	1x49	cb2_off	5.01	3.51944	4	3	8
3	2x50	cb2_off	5.985	7.79222	4	3	9
4	3x29	cb2_off	4.6075	5.42778	4	3	4
5	3x50	cb2_off	4.974	6.00778	5	3	9
6	E2.T173	cb2_off	2.715	3.38	4	1	5
7	E2.R177	cb2_off	6.48	4.095	4	3	3
8	5x68	cb2_off	5.88	1.5	4	2	7
9	6x28	cb2_off	4.1625	2.02	4	3	4
10	6x29	cb2_off	4.885	2.64778	4	3	5
11	E3.L273	cb2_off	3.4625	4.01056	4	3	1
12	8x50	cb2_off	5.215	4.35833	4	3	8
13	8x53	cb2_off	3.8725	2.85917	4	2	7
14	2x40	Shared	6.785	6.67833	8	6	8
15	2x46	Shared	3.83	3.96967	4	5	9
16	2x51	Shared	2.94	4.03833	4	4	7
17	2x61	Shared	5.44	5.86767	5	5	6
18	2x64	Shared	6.6975	6.238	4	5	3
19	3x25	Shared	6.098	4.244	5	5	9
20	3x49	Shared	6.9475	6.8025	4	4	9
21	I2x53	Shared	7.58	6.03875	4	4	7
22	E2.W172	Shared	7.172	4.21533	5	5	5
23	E2.I186	Shared	4.154	3.584	5	5	5
24	5x36	Shared	4.145	4.84417	4	4	4
25	5x39	Shared	7.83	4.90444	4	6	7
26	5x43	Shared	7.36	7.46917	4	6	5
27	5x58	Shared	5.686	6.25555	5	6	9
28	6x48	Shared	4.778	5.96722	5	6	8
29	7x53	Shared	4.595	5.45238	4	7	9
30	8x49	Shared	8.215	4.645	4	4	6
31	Lig	Shared	6.64	8.24988	17	14	0
32	NT.M22	cb2_on	12.44	2.24933	1	5	7
33	1x32	cb2_on	6.50333	2.71667	3	4	5
34	1x42	cb2_on	5.54	3.13033	1	5	6
35	2x42	cb2_on	5.32333	5.23583	3	4	8
36	2x57	cb2_on	6.735	5.82306	2	6	6
37	2x65	cb2_on	6.89667	6.46792	3	4	4
38	2x66	cb2_on	4.48	2.78	3	4	4
39	3x34	cb2_on	4.60333	4.86792	3	4	5
40	3x36	cb2_on	7.13	5.157	2	5	6
41	3x44	cb2_on	4.28	2.89125	2	4	6
42	3x56	cb2_on	10.41	5.87433	2	5	5
43	4x46	cb2_on	6.33	4.56875	2	4	8
44	4x50	cb2_on	5.41333	4.469	3	5	9
45	4x58	cb2_on	5.14333	4.70792	3	4	4
46	4x61	cb2_on	1.85333	2.82917	3	4	6
47	E2.F183	cb2_on	9.59	9.067	3	5	6
48	5x50	cb2_on	8.46	3.36042	2	4	7
49	5x51	cb2_on	3.77	5.04	3	5	7
50	5x73	cb2_on	0	0.4225	0	4	0
51	6x30	cb2_on	5.11	5.04375	3	4	7
52	6x55	cb2_on	4.39	4.28792	2	4	6
53	7x34	cb2_on	9.13	5.952	2	5	4
54	7x47	cb2_on	4.69333	4.10792	3	4	6
55	7x52	cb2_on	3.07	3.40375	1	4	9

Orange: nodes, hubs and links specific of cb2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cb2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	cb2_off Recurrence	cb2_on Recurrence	cb2_off Hub1?	cb2_on Hub1?	cb2_off Hub2?	cb2_on Hub2?	ConSurf1	ConSurf2
1	NT.P20	NT.P21	cb2_off	12.3775	0	Yes	No	No	No	7	4
2	3x25	E2.P184	cb2_off	19.266	3.52563	Yes	Yes	No	No	9	5
3	E2.P184	NT.Y25	cb2_off	16.5312	2.68108	No	No	No	No	5	4
4	NT.P20	NT.Y25	cb2_off	13.7642	0	Yes	No	No	No	7	4
5	2x64	3x25	cb2_off	17.1569	3.97247	Yes	Yes	Yes	Yes	3	9
6	6x58	E3.L273	cb2_off	27.6638	0	No	No	Yes	No	3	1
7	6x58	E2.L182	cb2_off	29.4053	2.94919	No	No	No	No	3	4
8	E2.F183	E2.L182	cb2_off	42.7116	3.12346	No	Yes	No	No	6	4
9	3x25	3x29	cb2_off	18.8725	4.27186	Yes	Yes	Yes	No	9	4
10	3x29	Lig	cb2_off	16.6538	4.55784	Yes	No	Yes	Yes	4	0
11	5x36	E2.I186	cb2_off	17.2665	9.36592	Yes	Yes	Yes	Yes	4	5
12	5x36	E2.C174	cb2_off	10.5973	5.17003	Yes	Yes	No	No	4	5
13	1x46	2x54	cb2_off	10.6747	1.85442	No	No	No	No	7	8
14	1x46	7x46	cb2_off	18.1566	0	No	No	No	No	7	9
15	2x50	7x46	cb2_off	20.7043	1.83654	Yes	No	No	No	9	9
16	2x46	2x50	cb2_off	51.2061	0	Yes	Yes	Yes	No	9	9
17	6x48	Lig	cb2_off	87.3645	0	Yes	Yes	Yes	Yes	8	0
18	1x53	7x50	cb2_off	10.6747	0	No	No	No	No	9	9
19	8x50	8x53	cb2_off	13.532	0	Yes	No	Yes	No	8	7
20	7x53	8x50	cb2_off	56.9724	0	Yes	Yes	Yes	No	9	8
21	6x40	7x53	cb2_off	100	1.42544	No	No	Yes	Yes	8	9
22	6x40	7x49	cb2_off	99.5292	0	No	No	No	No	8	9
23	2x40	2x43	cb2_off	45.5947	1.76505	Yes	Yes	No	No	8	8
24	2x43	7x53	cb2_off	46.0333	0	No	No	Yes	Yes	8	9
25	2x40	8x49	cb2_off	46.5622	0.134054	Yes	Yes	Yes	Yes	8	6
26	8x49	I1x49	cb2_off	23.71	0	Yes	Yes	No	No	6	6
27	4x39	I1.R66	cb2_off	10.0684	0	No	No	No	No	3	7
28	I1.R66	I1x48	cb2_off	16.9247	4.26293	No	No	No	No	7	5
29	I1x48	I1x49	cb2_off	20.3238	0	No	No	No	No	5	6
30	2x45	4x50	cb2_off	57.4497	6.64015	No	No	No	Yes	9	9
31	2x39	2x40	cb2_off	36.6099	0	No	No	Yes	Yes	8	8
32	3x49	3x50	cb2_off	65.8088	0	Yes	Yes	Yes	No	9	9
33	2x40	6x33	cb2_off	36.5583	0	Yes	Yes	No	No	8	7
34	2x48	4x50	cb2_off	18.563	0	No	No	No	Yes	7	9
35	2x48	2x52	cb2_off	16.557	0	No	No	No	No	7	7
36	2x51	2x52	cb2_off	10.4425	0	Yes	Yes	No	No	7	7
37	3x25	E1.D101	cb2_off	11.6551	0	Yes	Yes	No	No	9	2
38	4x60	E2.T173	cb2_off	29.3086	0	No	No	Yes	No	5	5
39	4x60	E2.I186	cb2_off	17.9889	0	No	No	Yes	Yes	5	5
40	3x26	E2.T173	cb2_off	13.1514	0	No	No	Yes	No	5	5
41	3x44	3x48	cb2_off	29.8633	2.92685	No	Yes	No	No	6	6
42	3x48	3x52	cb2_off	58.1721	0	No	No	No	No	6	5
43	3x52	I2x56	cb2_off	60.6682	0	No	No	No	No	5	4
44	I2x56	I2x57	cb2_off	63.1514	0	No	No	No	No	4	6
45	3x44	5x54	cb2_off	27.2123	2.92685	No	Yes	No	No	6	8
46	3x48	5x57	cb2_off	27.2123	0	No	No	No	No	6	6
47	3x50	6x30	cb2_off	20.6592	0	Yes	No	No	Yes	9	7
48	5x68	I3.M237	cb2_off	14.7833	0	Yes	No	No	No	7	4
49	6x30	I3.M237	cb2_off	17.7051	1.68015	No	Yes	No	No	7	4
50	4x60	5x39	cb2_off	15.0219	2.48447	No	No	Yes	Yes	5	7
51	5x39	Lig	cb2_off	24.9355	0	Yes	Yes	Yes	Yes	7	0
52	E2.I186	E2.S180	cb2_off	13.0869	0	Yes	Yes	No	No	5	4
53	7x34	E2.L182	cb2_off	13.1063	2.59618	No	Yes	No	No	4	4
54	3x55	5x64	cb2_off	13.7642	4.86617	No	No	No	No	6	6
55	5x58	6x41	cb2_off	19.1757	3.33795	Yes	Yes	No	No	9	7
56	5x54	6x41	cb2_off	24.5485	0	No	No	No	No	8	7
57	6x28	6x29	cb2_off	10.307	0	Yes	No	Yes	No	4	5
58	6x29	8x49	cb2_off	20.3173	0	Yes	No	Yes	Yes	5	6
59	6x36	7x53	cb2_off	11.8034	0	No	No	Yes	Yes	8	9
60	6x44	7x45	cb2_off	15.6282	0	No	No	No	No	9	9
61	6x54	7x34	cb2_off	11.41	3.36476	No	No	No	Yes	4	4
62	E2.F183	Lig	cb2_off	38.1643	9.28102	No	Yes	Yes	Yes	6	0
63	2x39	3x50	cb2_off	34.6556	0	No	No	Yes	No	8	9
64	3x50	6x33	cb2_off	34.8104	0	Yes	No	No	No	9	7
65	2x64	NT.M26	Shared	15.9572	19.2234	Yes	Yes	No	No	3	6
66	E1.H98	NT.M26	Shared	10.7521	17.7979	No	No	No	No	4	6
67	7x31	E2.E181	Shared	11.41	28.3882	No	No	No	No	2	4
68	E2.E181	E3.L273	Shared	15.1122	19.0044	No	No	Yes	No	4	1
69	2x61	Lig	Shared	15.5895	29.8539	Yes	Yes	Yes	Yes	6	0
70	2x64	Lig	Shared	34.3911	51.4053	Yes	Yes	Yes	Yes	3	0
71	E2.I186	Lig	Shared	40.338	15.9569	Yes	Yes	Yes	Yes	5	0
72	2x46	3x43	Shared	92.0924	12.1677	Yes	Yes	No	No	9	8
73	3x43	6x44	Shared	91.6602	57.8355	No	No	No	No	8	9
74	6x44	6x48	Shared	88.7255	43.1878	No	No	Yes	Yes	9	8
75	1x49	7x50	Shared	13.2869	12.9765	Yes	No	No	No	8	9
76	1x50	7x50	Shared	25.8965	13.1105	No	No	No	No	9	9
77	1x50	2x50	Shared	28.4443	22.0117	No	No	Yes	No	9	9
78	2x46	7x49	Shared	99.2131	28.1469	Yes	Yes	No	No	9	9
79	2x40	I1x50	Shared	10.436	20.269	Yes	Yes	No	No	8	8
80	2x40	8x50	Shared	47.2136	13.6601	Yes	Yes	Yes	No	8	8
81	2x42	3x49	Shared	56.4628	75.1687	No	Yes	Yes	Yes	8	9
82	2x42	4x46	Shared	55.9533	100	No	Yes	No	Yes	8	8
83	2x45	4x46	Shared	55.6179	37.4682	No	No	No	Yes	9	8
84	3x38	4x50	Shared	60.4876	14.7907	No	No	No	Yes	7	9
85	3x38	4x53	Shared	60.7521	14.8264	No	No	No	No	7	8
86	3x37	4x53	Shared	61.1649	15.2107	No	No	No	No	6	8
87	3x37	5x43	Shared	57.4239	10.1881	No	No	Yes	Yes	6	5
88	5x43	Lig	Shared	64.4092	15.1705	Yes	Yes	Yes	Yes	5	0
89	3x34	4x57	Shared	12.7257	59.0509	No	Yes	No	No	5	7
90	3x33	4x57	Shared	10.5457	59.2699	No	No	No	No	4	7
91	3x33	Lig	Shared	11.1649	49.3096	No	No	Yes	Yes	4	0
92	5x47	5x51	Shared	11.2552	16.9757	No	No	No	Yes	7	7
93	5x43	5x47	Shared	13.1063	11.971	Yes	Yes	No	No	5	7
94	3x49	I2x57	Shared	64.0093	64.842	Yes	Yes	No	No	9	6
95	3x51	5x57	Shared	24.5485	12.9452	No	No	No	No	8	6
96	3x51	3x55	Shared	21.8718	10.2105	No	No	No	No	8	6
97	5x37	E2.S180	Shared	11.2552	10.1122	No	No	No	No	4	4
98	6x47	7x45	Shared	13.0547	15.0811	No	No	No	No	8	9
99	7x31	NT.I27	cb2_on	9.53947	31.4983	No	No	No	No	2	5
100	7x32	NT.I27	cb2_on	5.7598	34.5994	No	No	No	No	2	5
101	7x32	NT.L28	cb2_on	0	43.8491	No	No	No	No	2	6
102	2x65	NT.L28	cb2_on	0	62.1073	No	Yes	No	No	4	6
103	2x64	2x65	cb2_on	4.32147	28.7904	Yes	Yes	No	Yes	3	4
104	1x32	E1.H98	cb2_on	0	14.9202	No	Yes	No	No	5	4
105	1x31	NT.L28	cb2_on	0	15.8586	No	No	No	No	5	6
106	1x31	7x36	cb2_on	0	12.7039	No	No	No	No	5	4
107	1x42	7x42	cb2_on	0	23.178	No	Yes	No	No	6	6
108	2x57	7x42	cb2_on	0	24.4649	No	Yes	No	No	6	6
109	2x57	Lig	cb2_on	1.81889	17.1545	No	Yes	Yes	Yes	6	0
110	2x61	2x65	cb2_on	4.11507	39.4522	Yes	Yes	No	Yes	6	4
111	1x42	7x47	cb2_on	0	16.7434	No	Yes	No	Yes	6	6
112	2x50	7x49	cb2_on	0	25.1665	Yes	No	No	No	9	9
113	7x45	7x49	cb2_on	0	22.9143	No	No	No	No	9	9
114	6x48	7x45	cb2_on	0	26.1719	Yes	Yes	No	No	8	9
115	3x36	6x48	cb2_on	0.819143	63.7249	No	Yes	Yes	Yes	6	8
116	3x36	Lig	cb2_on	1.30289	51.6109	No	Yes	Yes	Yes	6	0
117	1x49	7x47	cb2_on	0.374097	13.3473	Yes	No	No	Yes	8	6
118	1x55	8x57	cb2_on	0	16.7881	No	No	No	No	5	6
119	1x56	8x57	cb2_on	0	19.706	No	No	No	No	8	6
120	1x56	8x53	cb2_on	6.0565	26.3551	No	No	Yes	No	8	7
121	1x60	8x53	cb2_on	6.0952	29.6617	No	No	Yes	No	7	7
122	1x60	I1x50	cb2_on	4.44401	36.6013	No	No	No	No	7	8
123	2x37	2x40	cb2_on	3.36687	36.6817	No	No	Yes	Yes	6	8
124	2x37	2x38	cb2_on	0	61.9688	No	No	No	No	6	5
125	2x38	I2x57	cb2_on	0	63.3808	No	No	No	No	5	6
126	4x46	4x50	cb2_on	0	64.7705	No	Yes	No	Yes	8	9
127	3x34	4x50	cb2_on	0	57.2814	No	Yes	No	Yes	5	9
128	8x49	I1x50	cb2_on	0	19.5183	Yes	Yes	No	No	6	8
129	2x37	8x49	cb2_on	0.0773994	23.8885	No	No	Yes	Yes	6	6
130	2x41	4x42	cb2_on	0	17.7354	No	No	No	No	4	7
131	2x42	4x42	cb2_on	2.44453	19.4066	No	Yes	No	No	8	7
132	2x41	4x43	cb2_on	3.45717	16.1491	No	No	No	No	4	1
133	2x42	3x45	cb2_on	0	10.7735	No	Yes	No	No	8	6
134	2x45	3x42	cb2_on	8.45588	43.59	No	No	No	No	9	8
135	2x46	3x42	cb2_on	0	44.4792	Yes	Yes	No	No	9	8
136	3x43	7x53	cb2_on	0	45.5069	No	No	Yes	Yes	8	9
137	3x34	4x58	cb2_on	8.53328	14.2321	No	Yes	No	Yes	5	4
138	2x60	Lig	cb2_on	1.72214	11.0729	No	No	Yes	Yes	4	0
139	3x40	6x48	cb2_on	0	21.2655	No	No	Yes	Yes	8	8
140	3x40	5x50	cb2_on	5.62435	31.4804	No	No	No	Yes	8	7
141	3x44	5x50	cb2_on	0	14.5628	No	Yes	No	Yes	6	7
142	3x47	5x58	cb2_on	0	15.0722	No	No	Yes	Yes	9	9
143	5x58	7x53	cb2_on	0	58.5817	Yes	Yes	Yes	Yes	9	9
144	3x47	5x57	cb2_on	0	13.9282	No	No	No	No	9	6
145	3x49	I2x53	cb2_on	6.08875	14.7728	Yes	Yes	Yes	Yes	9	7
146	3x54	5x61	cb2_on	0	39.6041	No	No	No	No	9	9
147	5x61	6x37	cb2_on	0	41.0966	No	No	No	No	9	8
148	5x58	6x37	cb2_on	8.27528	45.4131	Yes	Yes	No	No	9	8
149	3x52	I2x53	cb2_on	0	10.6305	No	No	Yes	Yes	5	7
150	4x39	4x43	cb2_on	0	14.6253	No	No	No	No	3	1
151	5x46	5x50	cb2_on	3.72162	11.3991	No	No	No	Yes	5	7
152	5x39	E2.W172	cb2_on	8.03664	19.2636	Yes	Yes	Yes	Yes	7	5
153	5x39	5x43	cb2_on	0	22.8697	Yes	Yes	Yes	Yes	7	5
154	5x40	E2.S180	cb2_on	0	12.619	No	No	No	No	5	4
155	5x40	6x55	cb2_on	0	15.1169	No	No	No	Yes	5	6
156	5x43	6x55	cb2_on	0	16.3993	Yes	Yes	No	Yes	5	6
157	5x69	6x30	cb2_on	0	11.5778	No	No	No	Yes	5	7
158	5x69	6x29	cb2_on	0	23.5221	No	No	Yes	No	5	5
159	6x29	6x33	cb2_on	0	35.292	Yes	No	No	No	5	7
160	3x54	6x33	cb2_on	0	36.6638	No	No	No	No	9	7
161	1x49	7x51	cb2_on	8.02374	10.769	Yes	No	No	No	8	6
162	1x53	7x54	cb2_on	0	10.4786	No	No	No	No	9	8
163	7x54	8x50	cb2_on	0	12.1945	No	No	Yes	No	8	8
164	1x55	8x61	cb2_on	2.15428	10.0988	No	No	No	No	5	3
165	5x68	6x29	cb2_on	0	11.1042	Yes	No	Yes	No	7	5
166	5x69	5x73	cb2_on	0	10.9388	No	No	No	Yes	5	0
167	2x57	2x61	cb2_on	0.0451496	14.4421	No	Yes	Yes	Yes	6	6
168	2x57	3x36	cb2_on	0	16.5825	No	Yes	No	Yes	6	6
169	2x46	7x53	cb2_on	0	25.5507	Yes	Yes	Yes	Yes	9	9
170	3x33	5x43	cb2_on	0.793344	10.7377	No	No	Yes	Yes	4	5
171	5x51	6x44	cb2_on	0	15.0945	No	Yes	No	No	7	9
172	3x40	5x51	cb2_on	7.51419	13.0435	No	No	No	Yes	8	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
3x25	NT.M22	Shared	12.44	3.31833	0	1	2	2
E2.P184	NT.Y25	Shared	23.64	14.6017	0	0	1	2
2x64	NT.M26	Shared	9.95	6.01167	0	1	1	2
1x35	2x61	cb2_off	3.93	0	0	0	2	1
1x39	2x61	Shared	4.19	3.26	0	1	2	1
1x39	7x39	Shared	4.86	4.32	0	1	2	2
2x57	2x61	Shared	3.22	5.535	1	1	1	1
2x57	Lig	Shared	10.25	9.48333	1	1	1	0
2x60	Lig	Shared	3.16	3.76	0	0	1	0
2x61	2x65	Shared	12.44	13.1983	1	1	1	2
2x61	Lig	Shared	3.42	3.82167	1	1	1	0
2x64	2x65	Shared	6.79	7.35167	0	1	1	2
2x64	3x25	Shared	3.22	3.93	0	1	1	2
2x64	Lig	Shared	6.83	10.785	0	1	1	0
3x25	3x29	Shared	3.77	6.28	0	1	2	1
3x25	E2.P184	Shared	8.67	5.05333	0	1	2	1
3x29	E2.F183	cb2_off	3.77	0	1	1	1	1
3x29	E2.I186	Shared	5.89	3.435	1	1	1	1
3x29	Lig	Shared	5	6.56833	1	1	1	0
3x32	Lig	Shared	5.22	3.88	0	1	1	0
3x33	4x57	Shared	6.4	5.06333	1	1	1	2
3x33	5x43	Shared	4.85	4.64667	1	1	1	1
3x33	Lig	Shared	5.17	10.95	1	1	1	0
3x36	6x48	Shared	4.01	7.685	1	1	1	1
3x36	Lig	Shared	10.25	3.995	1	1	1	0
3x37	4x57	cb2_off	3.2	0	0	1	2	2
3x37	5x43	Shared	3.64	6.06333	0	1	2	1
3x40	5x51	Shared	3.93	5.67833	0	1	2	2
4x59	E2.W172	Shared	5.69	4.175	1	0	2	2
4x59	5x39	cb2_off	5.86	0	1	0	2	1
4x60	E2.I186	cb2_off	3.39	0	0	0	2	1
4x60	5x39	Shared	12.52	12.285	0	0	2	1
5x39	E2.W172	Shared	9.65	4.66167	1	1	1	2
E2.I186	E2.S180	cb2_off	3.1	0	1	1	1	2
E2.F183	E2.L182	Shared	3.65	4.265	1	1	1	2
7x34	E2.L182	Shared	14.61	9.135	0	1	1	2
E2.F183	Lig	Shared	21.35	26.845	1	1	1	0
5x36	E2.I186	Shared	3.39	3.95333	1	1	2	1
E2.I186	Lig	Shared	5	3.33667	1	1	1	0
5x39	Lig	cb2_off	3.29	0	1	1	1	0
5x43	5x47	Shared	10.57	11.7433	1	1	1	2
5x43	Lig	Shared	10.38	13.5033	1	1	1	0
6x44	6x48	Shared	4.56	3.23	0	1	2	1
6x44	7x45	cb2_off	5.49	0	0	1	2	2
6x48	6x52	cb2_off	3.42	0	1	1	1	2
6x48	7x41	Shared	3.92	7.40333	1	1	1	1
6x48	Lig	cb2_off	7.98	0	1	1	1	0
6x51	7x41	cb2_off	3.42	0	1	0	1	1
6x51	Lig	cb2_off	3.13	0	1	0	1	0
6x54	7x34	Shared	3.65	5.48167	0	0	2	1
6x55	Lig	cb2_off	5.95	0	0	0	1	0
7x38	Lig	Shared	3.16	7.32	0	1	1	0
7x41	Lig	cb2_off	3.34	0	1	1	1	0
5x44	6x55	Shared	2.83	5.18	0	0	2	1
5x47	5x51	Shared	2.51	4.605	0	1	2	2
5x42	E2.W172	cb2_off	2.47	0	0	0	2	2
NT.M22	NT.Y25	cb2_on	0	3.19167	0	1	2	2
2x64	NT.M22	cb2_on	0	3.11167	0	1	1	2
2x53	3x36	cb2_on	0	3.92833	0	0	2	1
2x57	3x32	cb2_on	0	4.58667	1	1	1	1
2x57	3x36	cb2_on	0	4.82333	1	1	1	1
2x57	7x38	cb2_on	0	4.62333	1	1	1	1
2x57	7x42	cb2_on	0	5.88667	1	1	1	2
2x60	3x28	cb2_on	0	5.865	0	0	1	2
3x36	7x41	cb2_on	0	5.35333	1	1	1	1
3x37	5x47	cb2_on	0	3.29333	0	1	2	2
3x40	6x48	cb2_on	0	3.065	0	1	2	1
5x36	E2.W172	cb2_on	0	8.33167	1	1	2	2
5x40	E2.S180	cb2_on	0	3	0	0	2	2
E2.F183	E2.I186	cb2_on	0	3.76833	1	1	1	1
6x55	E2.F183	cb2_on	0	4.56167	0	0	1	1
7x34	E2.F183	cb2_on	0	5.895	0	1	1	1
E2.P184	Lig	cb2_on	0	4.84	0	0	1	0
5x39	E2.I186	cb2_on	0	3.42667	1	1	1	1
5x36	5x39	cb2_on	0	3.01167	1	1	2	1
5x39	5x43	cb2_on	0	4.98167	1	1	1	1
5x40	6x55	cb2_on	0	3.53333	0	0	2	1
5x43	6x55	cb2_on	0	3.87667	1	1	1	1
5x51	6x44	cb2_on	0	4.26167	0	1	2	2
5x51	6x48	cb2_on	0	8.01667	0	1	2	1
6x48	7x45	cb2_on	0	6.40333	1	1	1	2
7x34	Lig	cb2_on	0	6.41	0	1	1	0
2x61	7x39	cb2_on	0	3.52333	1	1	1	2
6x51	7x34	cb2_on	0	2.83833	1	0	1	1
5x51	6x52	cb2_on	0	2.63833	0	1	2	2
5x39	5x42	cb2_on	0	1.06	1	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	cb2_off	5ZTY-CB₂-AM10257
	cb2_on	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2

Network Difference
Value	cb2_off	cb2_on
I_min	3	2.97667
Number of Linked Nodes	258	290
Number of Specific Nodes	5 (1.94%)	37 (12.76%)
Number of Shared Nodes	253 (98.06%)	253 (87.24%)
Number of Links	285	328
Number of Specific Links	112 (39.30%)	155 (47.26%)
Number of Shared Links	173 (60.70%)	173 (52.74%)
Number of Hubs	31	42
Number of Specific Hubs	13 (41.94%)	24 (57.14%)
Number of Shared Hubs	18 (58.06%)	18 (42.86%)
Average % Shared Neighbours (Jaccard)	41.91
Average % Shared Neighbours (Otsuka)	51.38
Average % Shared Neighbours (Overlap Coefficient)	61.52
Average % Shared Cliques (k3-6)	52.78
Graphlets Similarity	0.583687

Paths Difference
Value	cb2_off	cb2_on
Number Of Nodes in MetaPath	94	97
Specific Nodes in MetaPath	38 (40.43%)	41 (42.27%)
Shared Nodes in MetaPath	253 (98.06%)	253 (98.06%)
Number Of Links MetaPath	98	108
Specific Links in MetaPath	64 (65.31%)	74 (68.52%)
Shared Links in MetaPath	173 (60.70%)	173 (60.70%)
Number of Shortest Paths	46894	66495
Length Of Smallest Path	3	3
Average Path Length	13.6086	13.4413
Length of Longest Path	31	32
Minimum Path Strength	1.1	0.29
Average Path Strength	5.45344	5.01632
Maximum Path Strength	16.465	17.3639
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.924288	0.925996
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.34783	3.57143
Average % Of Corr. Nodes	49.3217	48.8397
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	36.1497	42.0336
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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