psnGPCR

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Orange: nodes, hubs and links specific of cck_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cck_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	cck_off Int. Strength	cck_on Int. Strength	cck_off Hub1?	cck_on Hub1?	cck_off Hub2?	cck_on Hub2?	ConSurf1	ConSurf2
1	1x31	NT	cck_off	100	0	Yes	No	No	No	1	5
2	1x31	1x32	cck_off	100	0	Yes	No	No	No	1	4
3	1x43	2x54	cck_off	100	0	Yes	No	No	No	5	7
4	1x46	1x50	cck_off	100	0	Yes	No	Yes	No	8	9
5	1x49	7x50	cck_off	100	0	No	No	No	No	8	9
6	1x53	7x53	cck_off	100	0	No	Yes	No	Yes	9	9
7	1x59	1x60	cck_off	100	0	No	No	No	No	5	6
8	2x39	3x49	cck_off	100	0	No	No	No	Yes	8	9
9	2x39	3x50	cck_off	100	0	No	No	Yes	No	8	9
10	2x40	2x43	cck_off	100	0	No	No	No	No	9	8
11	2x46	3x39	cck_off	100	0	No	No	No	No	9	9
12	2x48	4x50	cck_off	100	0	No	No	Yes	No	6	9
13	2x49	3x35	cck_off	100	0	No	No	No	No	8	6
14	2x52	4x50	cck_off	100	0	No	No	Yes	No	7	9
15	2x53	3x32	cck_off	100	0	Yes	No	No	No	8	7
16	2x53	6x48	cck_off	100	0	Yes	No	Yes	Yes	8	8
17	2x53	7x42	cck_off	100	0	Yes	No	Yes	Yes	8	7
18	2x59	3x24	cck_off	100	0	No	No	No	No	6	5
19	2x60	7x38	cck_off	100	0	No	No	No	No	7	6
20	2x62	E1x52	cck_off	100	0	No	No	Yes	Yes	5	6
21	2x63	E1x52	cck_off	100	0	No	No	Yes	Yes	5	6
22	2x64	7x35	cck_off	100	0	No	No	No	No	6	5
23	2x66	E1x51	cck_off	100	0	No	No	No	No	4	4
24	E1x49	E1x51	cck_off	100	0	No	No	No	No	4	4
25	E1x50	E2	cck_off	100	0	Yes	Yes	Yes	Yes	8	3
26	3x26	E2	cck_off	100	0	No	No	Yes	Yes	5	3
27	3x29	Lig	cck_off	100	0	No	No	Yes	Yes	6	0
28	3x30	4x59	cck_off	100	0	No	Yes	No	No	6	4
29	3x31	4x54	cck_off	100	0	Yes	Yes	No	No	5	4
30	3x32	7x42	cck_off	100	0	No	No	Yes	Yes	7	7
31	3x36	6x52	cck_off	100	0	No	No	Yes	Yes	7	7
32	3x38	3x42	cck_off	100	0	Yes	No	No	No	8	8
33	3x38	4x49	cck_off	100	0	Yes	No	No	No	8	7
34	3x39	6x44	cck_off	100	0	No	No	Yes	No	9	9
35	3x40	3x41	cck_off	100	0	No	No	No	No	8	6
36	3x40	5x461	cck_off	100	0	No	No	No	No	8	7
37	3x41	3x44	cck_off	100	0	No	No	No	No	6	7
38	3x41	5x50	cck_off	100	0	No	No	No	No	6	9
39	3x42	4x49	cck_off	100	0	No	No	No	No	8	7
40	3x43	6x41	cck_off	100	0	No	No	No	No	8	8
41	3x43	6x44	cck_off	100	0	No	No	Yes	No	8	9
42	3x44	5x54	cck_off	100	0	No	No	No	No	7	8
43	3x46	6x37	cck_off	100	0	No	No	No	Yes	9	8
44	3x49	3x50	cck_off	100	0	No	Yes	Yes	No	9	9
45	3x50	3x53	cck_off	100	0	Yes	No	No	No	9	8
46	3x50	3x54	cck_off	100	0	Yes	No	No	No	9	9
47	3x50	6x34	cck_off	100	0	Yes	No	No	No	9	8
48	3x54	5x65	cck_off	100	0	No	No	No	No	9	9
49	3x56	I2x53	cck_off	100	0	Yes	No	No	No	6	8
50	I2x54	I2x57	cck_off	100	0	No	No	No	Yes	6	7
51	4x41	4x44	cck_off	100	0	Yes	Yes	No	No	7	4
52	6x58	E2x51	cck_off	100	0	No	No	No	No	4	4
53	E2x51	E3	cck_off	100	0	No	No	Yes	Yes	4	3
54	5x39	E2x52	cck_off	100	0	Yes	Yes	Yes	Yes	8	5
55	5x43	6x52	cck_off	100	0	No	No	Yes	Yes	7	7
56	5x54	6x41	cck_off	100	0	No	No	No	No	8	8
57	5x58	6x38	cck_off	100	0	Yes	Yes	No	No	9	7
58	5x61	6x34	cck_off	100	0	No	No	No	No	9	8
59	5x65	6x31	cck_off	100	0	No	No	No	No	9	6
60	6x27	6x28	cck_off	100	0	No	No	No	No	4	5
61	6x28	6x31	cck_off	100	0	No	No	No	No	5	6
62	6x36	6x40	cck_off	100	0	No	No	No	No	9	9
63	6x40	7x49	cck_off	100	0	No	No	Yes	No	9	9
64	6x44	6x45	cck_off	100	0	Yes	No	Yes	No	9	6
65	6x45	6x49	cck_off	100	0	Yes	No	No	No	6	6
66	6x51	Lig	cck_off	100	0	No	No	Yes	Yes	7	0
67	6x52	Lig	cck_off	100	0	Yes	Yes	Yes	Yes	7	0
68	7x48	7x49	cck_off	100	0	No	No	Yes	No	7	9
69	7x49	7x53	cck_off	100	0	Yes	No	No	Yes	9	9
70	4x39	I1x48	cck_off	100	0	No	No	No	No	4	7
71	I1x49	I1x50	cck_off	100	0	No	No	No	No	6	8
72	5x58	6x34	cck_off	50	0	Yes	Yes	No	No	9	8
73	1x39	2x57	cck_off	50	0	No	No	No	No	7	7
74	3x48	I2x56	cck_off	50	0	No	No	No	Yes	6	5
75	1x35	2x65	cck_off	50	0	No	No	No	No	4	5
76	6x50	7x40	cck_off	0	0	No	No	No	No	9	8
77	7x32	7x36	cck_off	50	0	No	No	No	No	3	4
78	1x30	1x34	cck_off	0	0	No	No	No	No	1	5
79	6x42	6x46	cck_off	0	0	No	No	No	No	6	5
80	5x40	6x56	cck_off	50	0	No	No	No	No	6	6
81	3x51	3x52	cck_off	0	0	Yes	Yes	No	No	8	6
82	2x38	I2x57	cck_off	50	0	No	No	No	Yes	7	7
83	1x54	2x44	cck_off	50	0	No	No	No	No	7	6
84	5x68	6x27	cck_off	0	0	No	No	No	No	7	4
85	2x58	2x62	cck_off	0	0	No	No	No	No	8	5
86	7x51	7x55	cck_off	0	0	No	No	No	Yes	6	6
87	6x32	7x56	cck_off	50	0	No	No	No	No	8	7
88	1x54	1x58	cck_off	0	0	No	No	No	No	7	3
89	2x41	4x46	cck_off	0	0	No	No	No	No	5	7
90	1x57	I1x50	cck_off	0	0	No	No	No	No	7	8
91	8x47	8x48	cck_off	50	0	No	No	No	No	9	6
92	7x31	7x33	cck_off	0	0	No	No	No	No	3	4
93	6x54	Lig	cck_off	0	0	No	No	Yes	Yes	5	0
94	5x44	5x47	cck_off	0	0	No	No	No	Yes	7	8
95	1x49	1x52	cck_off	0	0	No	No	No	No	8	7
96	5x34	5x38	cck_off	0	0	No	No	No	No	2	4
97	5x62	6x38	cck_off	0	0	No	No	No	No	6	7
98	5x37	6x59	cck_off	0	0	No	No	No	No	4	6
99	1x56	1x60	cck_off	0	0	No	No	No	No	8	6
100	5x41	5x45	cck_off	0	0	No	No	No	No	6	3
101	7x54	7x55	cck_off	0	0	No	No	No	Yes	8	6
102	1x43	1x44	cck_off	0	0	Yes	No	No	No	5	4
103	7x47	7x51	cck_off	0	0	No	No	No	No	7	6
104	I2x50	I2x51	cck_off	0	0	No	No	No	No	8	7
105	4x38	I2x55	cck_off	0	0	No	No	No	No	8	5
106	4x51	4x52	cck_off	0	0	No	No	No	No	4	5
107	1x36	1x40	cck_off	0	0	No	No	No	No	5	4
108	1x40	1x41	cck_off	0	0	No	No	No	No	4	4
109	4x52	4x55	cck_off	0	0	No	No	No	No	5	5
110	5x33	E3	cck_off	0	0	No	No	Yes	Yes	2	3
111	5x48	5x52	cck_off	0	0	No	No	No	No	6	4
112	7x56	8x47	cck_off	0	0	No	No	No	No	7	9
113	1x37	1x38	cck_off	0	0	No	No	No	No	4	5
114	5x60	5x63	cck_off	0	0	No	No	No	No	5	4
115	1x30	1x31	Shared	100	100	No	No	Yes	No	1	1
116	1x31	7x32	Shared	100	25	Yes	No	No	No	1	3
117	1x35	7x35	Shared	100	100	No	No	No	No	4	5
118	1x36	2x65	Shared	100	100	No	No	No	No	5	5
119	1x39	2x61	Shared	100	100	No	No	No	No	7	6
120	1x39	7x39	Shared	100	100	No	No	No	No	7	7
121	1x42	7x39	Shared	100	100	No	No	No	No	7	7
122	1x42	7x43	Shared	100	0	No	No	No	No	7	5
123	1x43	1x47	Shared	100	100	Yes	No	No	No	5	6
124	1x43	2x57	Shared	100	100	Yes	No	No	No	5	7
125	1x45	7x47	Shared	100	16.6667	No	No	No	No	5	7
126	1x46	2x54	Shared	100	100	Yes	No	No	No	8	7
127	1x46	7x46	Shared	100	16.6667	Yes	No	No	No	8	9
128	1x50	2x50	Shared	100	100	Yes	No	No	Yes	9	9
129	1x50	7x50	Shared	100	100	Yes	No	No	No	9	9
130	1x51	2x51	Shared	100	16.6667	No	No	No	No	4	7
131	1x57	2x44	Shared	100	100	No	No	No	No	7	6
132	1x60	I1x50	Shared	100	100	No	No	No	No	6	8
133	I1x48	I1x51	Shared	100	100	No	No	No	No	7	8
134	2x37	2x40	Shared	100	100	No	No	No	No	7	9
135	2x38	3x49	Shared	100	100	No	No	No	Yes	7	9
136	2x41	4x39	Shared	100	50	No	No	No	No	5	4
137	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	8
138	2x42	3x46	Shared	100	100	Yes	Yes	No	No	8	9
139	2x42	4x45	Shared	100	100	Yes	Yes	No	No	8	6
140	2x42	4x46	Shared	100	100	Yes	Yes	No	No	8	7
141	2x43	7x53	Shared	100	100	No	No	No	Yes	8	9
142	2x45	3x42	Shared	100	100	No	No	No	No	9	8
143	2x45	4x46	Shared	100	100	No	No	No	No	9	7
144	2x45	4x50	Shared	100	100	No	No	Yes	No	9	9
145	2x46	7x49	Shared	100	100	No	No	Yes	No	9	9
146	2x49	3x38	Shared	100	100	No	No	Yes	No	8	8
147	2x49	3x39	Shared	100	41.6667	No	No	No	No	8	9
148	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
149	2x51	2x55	Shared	100	0	No	No	No	No	7	5
150	2x52	3x31	Shared	100	100	No	No	Yes	Yes	7	5
151	2x53	3x35	Shared	100	100	Yes	No	No	No	8	6
152	2x551	3x31	Shared	100	100	No	No	Yes	Yes	5	5
153	2x56	7x42	Shared	100	100	No	No	Yes	Yes	7	7
154	2x57	7x42	Shared	100	100	No	No	Yes	Yes	7	7
155	2x59	E1x52	Shared	100	100	No	No	Yes	Yes	6	6
156	2x59	3x28	Shared	100	100	No	No	No	No	6	6
157	2x60	7x42	Shared	100	100	No	No	Yes	Yes	7	7
158	2x60	Lig	Shared	100	100	No	No	Yes	Yes	7	0
159	2x61	2x65	Shared	100	100	No	No	No	No	6	5
160	2x62	2x63	Shared	100	0	No	No	No	No	5	5
161	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	5	8
162	2x67	E2	Shared	100	50	No	No	Yes	Yes	4	3
163	E1x49	E2	Shared	100	50	No	No	Yes	Yes	4	3
164	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	8	6
165	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	8
166	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	8	9
167	3x24	E1x52	Shared	100	100	No	No	Yes	Yes	5	6
168	3x22	E2	Shared	100	75	No	No	Yes	Yes	4	3
169	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
170	3x29	4x61	Shared	100	100	No	No	Yes	Yes	6	7
171	3x29	4x65	Shared	100	100	No	No	No	No	6	6
172	3x30	4x54	Shared	100	100	No	Yes	No	No	6	4
173	3x30	4x62	Shared	100	100	No	Yes	No	No	6	6
174	3x32	Lig	Shared	100	100	No	No	Yes	Yes	7	0
175	3x34	4x54	Shared	100	100	No	No	No	No	6	4
176	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	8
177	3x37	4x53	Shared	100	100	No	No	No	No	7	8
178	3x38	4x50	Shared	100	100	Yes	No	Yes	No	8	9
179	3x38	4x53	Shared	100	100	Yes	No	No	No	8	8
180	3x40	6x44	Shared	100	33.3333	No	No	Yes	No	8	9
181	3x47	5x54	Shared	100	100	No	No	No	No	9	8
182	3x47	5x58	Shared	100	100	No	No	Yes	Yes	9	9
183	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	7
184	3x51	3x56	Shared	100	100	Yes	Yes	Yes	No	8	6
185	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	5
186	3x54	5x61	Shared	100	41.6667	No	No	No	No	9	9
187	3x56	I2x52	Shared	100	100	Yes	No	No	No	6	5
188	4x41	I2x56	Shared	100	100	Yes	Yes	No	Yes	7	5
189	4x41	4x45	Shared	100	100	Yes	Yes	No	No	7	6
190	4x57	4x61	Shared	100	100	No	No	Yes	Yes	8	7
191	4x59	4x60	Shared	100	100	No	No	No	No	4	8
192	4x60	5x39	Shared	100	100	No	No	Yes	Yes	8	8
193	4x61	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	7	5
194	4x61	5x39	Shared	100	100	Yes	Yes	Yes	Yes	7	8
195	4x61	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
196	4x63	4x64	Shared	100	100	No	No	No	Yes	5	5
197	4x64	E2	Shared	100	100	No	Yes	Yes	Yes	5	3
198	4x65	E2x52	Shared	100	100	No	No	Yes	Yes	6	5
199	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
200	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	4
201	E2	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	3	5
202	5x36	E2	Shared	100	100	No	No	Yes	Yes	5	3
203	5x35	E2	Shared	100	100	No	No	Yes	Yes	4	3
204	5x32	5x35	Shared	100	41.6667	No	No	No	No	5	4
205	5x36	5x40	Shared	100	100	No	No	No	No	5	6
206	5x37	6x60	Shared	100	100	No	No	No	No	4	5
207	5x39	5x42	Shared	100	50	Yes	Yes	No	No	8	5
208	5x39	5x43	Shared	100	100	Yes	Yes	No	No	8	7
209	5x42	5x46	Shared	100	100	No	No	No	No	5	5
210	5x47	6x45	Shared	100	100	No	Yes	Yes	No	8	6
211	5x47	6x52	Shared	100	100	No	Yes	Yes	Yes	8	7
212	5x51	6x45	Shared	100	75	No	No	Yes	No	6	6
213	5x58	6x37	Shared	100	100	Yes	Yes	No	Yes	9	8
214	5x69	6x27	Shared	100	50	No	No	No	No	5	4
215	6x36	7x56	Shared	100	100	No	No	No	No	9	7
216	6x40	7x52	Shared	100	100	No	No	No	No	9	9
217	6x43	7x48	Shared	100	75	No	Yes	No	No	6	7
218	6x44	6x48	Shared	100	100	Yes	No	Yes	Yes	9	8
219	6x47	7x45	Shared	100	100	No	No	No	No	8	9
220	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
221	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
222	6x48	7x45	Shared	100	100	Yes	Yes	No	No	8	9
223	6x50	7x37	Shared	100	100	No	No	No	No	9	6
224	6x51	7x37	Shared	100	100	No	No	No	No	7	6
225	6x51	7x41	Shared	100	100	No	No	No	No	7	7
226	6x55	Lig	Shared	100	100	No	No	Yes	Yes	7	0
227	6x57	E3	Shared	100	100	No	No	Yes	Yes	5	3
228	6x58	E3	Shared	100	100	No	No	Yes	Yes	4	3
229	6x58	Lig	Shared	100	100	No	No	Yes	Yes	4	0
230	6x61	E3	Shared	100	100	No	No	Yes	Yes	4	3
231	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	3	3
232	E3	Lig	Shared	100	100	Yes	Yes	Yes	Yes	3	0
233	7x33	E3	Shared	100	50	No	No	Yes	Yes	4	3
234	7x32	7x33	Shared	100	33.3333	No	No	No	No	3	4
235	7x34	7x37	Shared	100	100	No	No	No	No	5	6
236	7x34	Lig	Shared	100	100	No	No	Yes	Yes	5	0
237	E1x51	E1x52	Shared	100	100	No	No	Yes	Yes	4	6
238	5x40	6x59	Shared	50	100	No	No	No	No	6	6
239	3x51	5x61	Shared	50	25	Yes	Yes	No	No	8	9
240	3x33	4x57	Shared	0	100	No	No	No	No	6	8
241	1x38	7x39	Shared	50	100	No	No	No	No	5	7
242	1x46	7x47	Shared	0	41.6667	Yes	No	No	No	8	7
243	4x38	4x41	Shared	50	0	No	No	Yes	Yes	8	7
244	3x47	5x57	Shared	0	0	No	No	No	No	9	6
245	5x49	5x50	Shared	0	50	No	No	No	No	6	9
246	1x54	2x47	Shared	0	16.6667	No	No	No	No	7	9
247	3x27	3x31	Shared	50	50	No	No	Yes	Yes	4	5
248	6x24	6x28	Shared	0	0	No	No	No	No	4	5
249	3x44	5x53	Shared	50	16.6667	No	No	No	No	7	7
250	5x41	6x60	Shared	50	50	No	No	No	No	6	5
251	3x55	5x64	Shared	0	100	No	No	No	No	7	6
252	6x39	6x43	Shared	0	50	No	No	No	Yes	7	6
253	4x56	4x57	Shared	50	66.6667	No	No	No	No	6	8
254	5x65	6x30	Shared	50	75	No	No	No	Yes	9	8
255	2x42	4x42	Shared	0	100	Yes	Yes	No	No	8	7
256	1x50	2x51	Shared	50	100	Yes	No	No	No	9	7
257	1x48	1x49	Shared	0	0	No	No	No	No	4	8
258	1x53	2x47	Shared	0	50	No	Yes	No	No	9	9
259	4x38	4x40	Shared	0	100	No	No	No	No	8	5
260	5x56	5x60	Shared	0	0	No	No	No	No	5	5
261	6x33	6x37	Shared	0	0	No	No	No	Yes	9	8
262	5x32	5x34	Shared	0	25	No	No	No	No	5	2
263	6x32	6x35	Shared	50	50	No	No	No	No	8	7
264	5x45	5x48	Shared	50	58.3333	No	No	No	No	3	6
265	5x59	5x62	Shared	0	16.6667	No	No	No	No	1	6
266	3x56	I2x50	Shared	0	0	Yes	No	No	No	6	8
267	6x38	6x42	Shared	0	0	No	No	No	No	7	6
268	6x49	6x53	Shared	0	0	No	No	No	No	6	6
269	3x21	E1x52	Shared	0	0	No	No	Yes	Yes	7	6
270	2x41	4x43	Shared	0	25	No	No	No	No	5	5
271	6x29	6x32	Shared	0	16.6667	No	No	No	No	6	8
272	1x35	7x36	cck_on	0	100	No	No	No	No	4	4
273	1x39	7x35	cck_on	0	100	No	No	No	No	7	5
274	1x52	7x55	cck_on	0	100	No	No	No	Yes	7	6
275	1x53	7x54	cck_on	0	100	No	Yes	No	No	9	8
276	1x53	7x55	cck_on	0	100	No	Yes	No	Yes	9	6
277	1x56	8x50	cck_on	0	100	No	No	No	Yes	8	0
278	1x57	2x40	cck_on	0	100	No	No	No	No	7	9
279	1x60	I1x49	cck_on	0	100	No	No	No	No	6	6
280	2x40	I1x50	cck_on	0	100	No	No	No	No	9	8
281	2x37	2x39	cck_on	0	100	No	No	No	No	7	8
282	2x42	3x49	cck_on	0	100	Yes	Yes	No	Yes	8	9
283	2x43	7x54	cck_on	0	100	No	No	No	No	8	8
284	2x46	2x50	cck_on	0	100	No	No	No	Yes	9	9
285	2x50	7x49	cck_on	0	100	No	Yes	Yes	No	9	9
286	2x52	3x35	cck_on	0	100	No	No	No	No	7	6
287	2x53	2x56	cck_on	0	100	Yes	No	No	No	8	7
288	2x56	3x32	cck_on	0	100	No	No	No	No	7	7
289	2x58	2x59	cck_on	0	100	No	No	No	No	8	6
290	3x30	3x34	cck_on	0	100	No	Yes	No	No	6	6
291	3x36	Lig	cck_on	0	100	No	No	Yes	Yes	7	0
292	3x37	5x461	cck_on	0	100	No	No	No	No	7	7
293	3x41	4x49	cck_on	0	100	No	No	No	No	6	7
294	3x43	7x49	cck_on	0	100	No	No	Yes	No	8	9
295	3x43	7x53	cck_on	0	100	No	No	No	Yes	8	9
296	3x46	3x50	cck_on	0	100	No	No	Yes	No	9	9
297	3x46	7x53	cck_on	0	100	No	No	No	Yes	9	9
298	3x48	5x53	cck_on	0	100	No	No	No	No	6	7
299	3x49	I2x57	cck_on	0	100	No	Yes	No	Yes	9	7
300	3x49	4x41	cck_on	0	100	No	Yes	Yes	Yes	9	7
301	3x50	5x58	cck_on	0	100	Yes	No	Yes	Yes	9	9
302	3x50	7x53	cck_on	0	100	Yes	No	No	Yes	9	9
303	I2x53	I2x57	cck_on	0	100	No	No	No	Yes	8	7
304	I2x56	I2x57	cck_on	0	100	No	Yes	No	Yes	5	7
305	4x64	E2x52	cck_on	0	100	No	Yes	Yes	Yes	5	5
306	E2	Lig	cck_on	0	100	Yes	Yes	Yes	Yes	3	0
307	E2x51	Lig	cck_on	0	100	No	No	Yes	Yes	4	0
308	E2x52	Lig	cck_on	0	100	Yes	Yes	Yes	Yes	5	0
309	5x39	E2	cck_on	0	100	Yes	Yes	Yes	Yes	8	3
310	5x34	5x37	cck_on	0	100	No	No	No	No	2	4
311	5x461	6x52	cck_on	0	100	No	No	Yes	Yes	7	7
312	5x47	6x49	cck_on	0	100	No	Yes	No	No	8	6
313	5x54	6x44	cck_on	0	100	No	No	Yes	No	8	9
314	5x58	6x41	cck_on	0	100	Yes	Yes	No	No	9	8
315	5x62	6x34	cck_on	0	100	No	No	No	No	6	8
316	5x66	5x70	cck_on	0	100	No	No	No	No	6	0
317	6x26	6x30	cck_on	0	100	No	No	No	Yes	4	8
318	6x36	7x52	cck_on	0	100	No	No	No	No	9	9
319	6x40	7x53	cck_on	0	100	No	No	No	Yes	9	9
320	6x57	6x61	cck_on	0	100	No	No	No	No	5	4
321	7x34	7x38	cck_on	0	100	No	No	No	No	5	6
322	7x38	7x42	cck_on	0	100	No	No	Yes	Yes	6	7
323	7x41	7x42	cck_on	0	100	No	No	Yes	Yes	7	7
324	7x54	8x50	cck_on	0	100	No	No	No	Yes	8	0
325	7x55	8x50	cck_on	0	100	No	Yes	No	Yes	6	0
326	Lig	Lig	cck_on	0	100	Yes	Yes	Yes	Yes	0	0
327	1x60	8x52	cck_on	0	100	No	No	No	No	6	0
328	E1x52	E2	cck_on	0	100	Yes	Yes	Yes	Yes	6	3
329	3x29	4x64	cck_on	0	100	No	No	No	Yes	6	5
330	4x61	4x64	cck_on	0	100	Yes	Yes	No	Yes	7	5
331	7x38	Lig	cck_on	0	100	No	No	Yes	Yes	6	0
332	8x54	8x58	cck_on	0	100	No	No	No	No	0	0
333	4x39	I1x51	cck_on	0	100	No	No	No	No	4	8
334	8x47	8x49	cck_on	0	50	No	No	No	No	9	0
335	3x30	3x31	cck_on	0	50	No	Yes	Yes	Yes	6	5
336	1x41	1x45	cck_on	0	50	No	No	No	No	4	5
337	5x72	I3	cck_on	0	50	No	No	No	No	0	0
338	3x44	5x50	cck_on	0	50	No	No	No	No	7	9
339	1x54	2x48	cck_on	0	16.6667	No	No	No	No	7	6
340	6x36	8x47	cck_on	0	50	No	No	No	No	9	9
341	7x36	7x40	cck_on	0	50	No	No	No	No	4	8
342	1x56	8x57	cck_on	0	66.6667	No	No	No	No	8	0
343	1x49	7x55	cck_on	0	16.6667	No	No	No	Yes	8	6
344	5x44	6x52	cck_on	0	41.6667	No	No	Yes	Yes	7	7
345	5x65	6x33	cck_on	0	16.6667	No	No	No	No	9	9
346	5x61	6x37	cck_on	0	25	No	No	No	Yes	9	8
347	5x69	6x30	cck_on	0	50	No	No	No	Yes	5	8
348	2x66	E1x49	cck_on	0	50	No	No	No	No	4	4
349	8x48	8x51	cck_on	0	50	No	No	No	No	6	0
350	1x42	2x57	cck_on	0	50	No	No	No	No	7	7
351	3x40	5x50	cck_on	0	16.6667	No	No	No	No	8	9
352	1x53	1x57	cck_on	0	0	No	Yes	No	No	9	7
353	8x52	8x55	cck_on	0	41.6667	No	No	No	No	0	0
354	6x62	E3	cck_on	0	50	No	No	Yes	Yes	0	3
355	3x37	3x41	cck_on	0	50	No	No	No	No	7	6
356	3x53	I2x57	cck_on	0	58.3333	No	No	No	Yes	8	7
357	3x22	3x26	cck_on	0	58.3333	No	No	No	No	4	5
358	3x52	I2x56	cck_on	0	50	No	No	No	Yes	6	5
359	2x41	4x42	cck_on	0	25	No	No	No	No	5	7
360	2x64	Lig	cck_on	0	16.6667	No	No	Yes	Yes	6	0
361	1x58	2x44	cck_on	0	25	No	No	No	No	3	6
362	5x63	5x67	cck_on	0	50	No	No	No	No	4	5
363	5x44	6x56	cck_on	0	16.6667	No	No	No	No	7	6
364	1x32	1x35	cck_on	0	41.6667	No	No	No	No	4	4
365	6x28	6x32	cck_on	0	50	No	No	No	No	5	8
366	7x31	E3	cck_on	0	16.6667	No	No	Yes	Yes	3	3
367	5x62	6x37	cck_on	0	50	No	No	No	Yes	6	8
368	7x48	7x52	cck_on	0	0	No	No	No	No	7	9
369	5x47	5x48	cck_on	0	16.6667	No	Yes	No	No	8	6
370	1x56	8x53	cck_on	0	25	No	No	No	No	8	0
371	5x63	5x64	cck_on	0	50	No	No	No	No	4	6
372	8x54	8x57	cck_on	0	41.6667	No	No	No	No	0	0
373	7x51	7x56	cck_on	0	0	No	No	No	No	6	7
374	5x72	6x30	cck_on	0	25	No	No	No	Yes	0	8
375	5x33	5x37	cck_on	0	25	No	No	No	No	2	4
376	5x55	6x41	cck_on	0	0	No	No	No	No	6	8
377	8x48	8x50	cck_on	0	16.6667	No	No	No	Yes	6	0
378	5x66	6x34	cck_on	0	16.6667	No	No	No	No	6	8
379	5x35	5x38	cck_on	0	25	No	No	No	No	4	4
380	1x34	7x36	cck_on	0	16.6667	No	No	No	No	5	4
381	5x52	5x55	cck_on	0	0	No	No	No	No	4	6
382	6x54	E3	cck_on	0	0	No	No	Yes	Yes	5	3
383	I2x55	I2x56	cck_on	0	16.6667	No	No	No	Yes	5	5
384	1x44	1x45	cck_on	0	33.3333	No	No	No	No	4	5
385	6x27	6x31	cck_on	0	16.6667	No	No	No	No	4	6
386	I2x51	I2x52	cck_on	0	25	No	No	No	No	7	5
387	4x52	4x56	cck_on	0	0	No	No	No	No	5	6
388	1x51	1x55	cck_on	0	16.6667	No	No	No	No	4	4
389	8x53	8x56	cck_on	0	0	No	No	No	No	0	0
390	1x32	NT	cck_on	0	25	No	No	No	No	4	5
391	6x23	6x26	cck_on	0	0	No	No	No	No	0	4
392	5x67	5x68	cck_on	0	0	No	No	No	No	5	7
393	6x26	6x28	cck_on	0	0	No	No	No	No	4	5
394	1x59	8x56	cck_on	0	0	No	No	No	No	5	0
395	5x73	6x27	cck_on	0	0	No	No	No	No	0	4
396	5x68	5x71	cck_on	0	0	No	No	No	No	7	0
397	6x42	6x43	cck_on	0	0	No	No	No	Yes	6	6
398	4x47	4x51	cck_on	0	16.6667	No	No	No	No	4	4
399	4x44	4x47	cck_on	0	16.6667	No	No	No	No	4	4
400	1x34	1x37	cck_on	0	0	No	No	No	No	5	4
401	4x55	4x56	cck_on	0	0	No	No	No	No	5	6
402	4x40	4x44	cck_on	0	0	No	No	No	No	5	4
403	6x23	6x25	cck_on	0	0	No	No	No	No	0	4
404	6x43	6x46	cck_on	0	0	No	Yes	No	No	6	5
405	3x22	3x23	cck_on	0	0	No	No	No	No	4	3

Orange: nodes, hubs and links specific of cck_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cck_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	cck_off Avg Int. Strength	cck_on Avg Int. Strength	cck_off Num Of Links	cck_on Num Of Links	ConSurf
1	1x31	cck_off	0	0	4	2	1
2	1x43	cck_off	0	0	4	2	5
3	1x46	cck_off	0	0	4	3	8
4	1x50	cck_off	50	0	4	3	9
5	2x53	cck_off	50	0	4	2	8
6	3x38	cck_off	100	0	5	3	8
7	3x50	cck_off	50	0	5	3	9
8	3x56	cck_off	0	0	4	3	6
9	4x50	cck_off	100	0	4	2	9
10	6x44	cck_off	100	0	5	3	9
11	6x45	cck_off	0	0	4	2	6
12	7x49	cck_off	50	0	4	3	9
13	2x42	Shared	100	100	5	6	8
14	E1x50	Shared	100	33.3333	5	4	8
15	E1x52	Shared	100	50	7	6	6
16	3x31	Shared	50	25	4	4	5
17	3x51	Shared	0	0	5	4	8
18	4x41	Shared	0	0	4	4	7
19	4x61	Shared	100	100	5	6	7
20	E2	Shared	100	100	12	13	3
21	E2x52	Shared	100	83.3333	4	5	5
22	5x39	Shared	100	58.3333	5	5	8
23	5x58	Shared	50	100	4	4	9
24	6x48	Shared	100	100	6	5	8
25	6x52	Shared	100	0	5	4	7
26	E3	Shared	100	100	9	10	3
27	7x42	Shared	100	100	5	5	7
28	Lig	Shared	100	100	11	15	0
29	1x53	cck_on	0	0	2	4	9
30	2x50	cck_on	0	25	2	4	9
31	3x30	cck_on	0	0	3	4	6
32	3x49	cck_on	0	0	3	4	9
33	I2x56	cck_on	0	0	2	4	5
34	I2x57	cck_on	0	0	2	4	7
35	4x64	cck_on	0	0	2	5	5
36	5x47	cck_on	50	25	3	4	8
37	6x30	cck_on	0	0	1	4	8
38	6x37	cck_on	0	0	3	4	8
39	6x43	cck_on	0	0	2	4	6
40	7x53	cck_on	50	50	3	5	9
41	7x55	cck_on	0	0	2	4	6
42	8x50	cck_on	0	25	0	4	0

Orange: nodes, hubs and links specific of cck_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cck_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	cck_off Recurrence	cck_on Recurrence	cck_off Hub1?	cck_on Hub1?	cck_off Hub2?	cck_on Hub2?	ConSurf1	ConSurf2
1	7x33	E3	cck_off	12.6907	5.82953	No	No	Yes	Yes	4	3
2	2x60	Lig	cck_off	29.4521	8.64536	No	No	Yes	Yes	7	0
3	2x60	7x42	cck_off	29.3864	8.54389	No	No	Yes	Yes	7	7
4	1x39	2x57	cck_off	34.4382	0	No	No	No	No	7	7
5	1x39	2x61	cck_off	19.9023	5.5657	No	No	No	No	7	6
6	2x61	2x65	cck_off	17.4468	3.71892	No	No	No	No	6	5
7	3x32	Lig	cck_off	59.8056	5.55556	No	No	Yes	Yes	7	0
8	3x32	7x42	cck_off	27.837	0	No	No	Yes	Yes	7	7
9	1x43	2x57	cck_off	50.9695	3.71892	Yes	No	No	No	5	7
10	1x43	2x54	cck_off	43.941	0	Yes	No	No	No	5	7
11	1x46	2x54	cck_off	41.5794	1.48148	Yes	No	No	No	8	7
12	1x46	7x47	cck_off	12.5076	5.88026	Yes	No	No	No	8	7
13	1x46	1x50	cck_off	22.3015	0	Yes	No	Yes	No	8	9
14	1x50	7x50	cck_off	10.0239	1.48148	Yes	No	No	No	9	9
15	6x52	Lig	cck_off	64.9984	0	Yes	Yes	Yes	Yes	7	0
16	3x39	6x44	cck_off	47.1478	0	No	No	Yes	No	9	9
17	2x46	3x39	cck_off	53.0823	0	No	No	No	No	9	9
18	2x46	7x49	cck_off	51.3545	1.41045	No	No	Yes	No	9	9
19	7x49	7x53	cck_off	28.5647	0	Yes	No	No	Yes	9	9
20	1x53	7x53	cck_off	21.3672	0	No	Yes	No	Yes	9	9
21	1x53	2x47	cck_off	19.4798	4.51547	No	Yes	No	No	9	9
22	1x54	2x47	cck_off	17.5736	3.01877	No	No	No	No	7	9
23	1x54	2x44	cck_off	13.733	0	No	No	No	No	7	6
24	1x57	2x44	cck_off	11.7987	3.00863	No	No	No	No	7	6
25	2x53	3x32	cck_off	32.4381	0	Yes	No	No	No	8	7
26	2x49	3x35	cck_off	49.4906	0	No	No	No	No	8	6
27	2x49	3x38	cck_off	55.1575	2.97818	No	No	Yes	No	8	8
28	3x38	3x42	cck_off	24.0809	0	Yes	No	No	No	8	8
29	2x45	3x42	cck_off	23.4659	1.517	No	No	No	No	9	8
30	2x45	4x46	cck_off	50.5705	9.51801	No	No	No	No	9	7
31	2x41	4x46	cck_off	14.395	0	No	No	No	No	5	7
32	3x38	4x50	cck_off	28.2877	9.34551	Yes	No	Yes	No	8	9
33	2x45	4x50	cck_off	29.5507	9.3861	No	No	Yes	No	9	9
34	3x43	6x44	cck_off	65.5336	0	No	No	Yes	No	8	9
35	3x43	6x41	cck_off	64.4021	0	No	No	No	No	8	8
36	5x54	6x41	cck_off	63.3316	0	No	No	No	No	8	8
37	5x58	6x34	cck_off	58.2656	0	Yes	Yes	No	No	9	8
38	3x50	6x34	cck_off	23.9166	0	Yes	No	No	No	9	8
39	3x46	6x37	cck_off	10.2117	0	No	No	No	Yes	9	8
40	2x52	4x50	cck_off	10.3667	0	No	No	Yes	No	7	9
41	4x60	5x39	cck_off	10.7892	5.49467	No	No	Yes	Yes	8	8
42	E2x51	E3	cck_off	43.002	0	No	No	Yes	Yes	4	3
43	E2	E2x51	cck_off	82.0602	0.167428	Yes	Yes	No	No	3	4
44	E1x50	E2	cck_off	53.1574	0	Yes	Yes	Yes	Yes	8	3
45	E1x50	E1x52	cck_off	28.9075	8.0619	Yes	Yes	Yes	Yes	8	6
46	2x63	E1x50	cck_off	12.7612	3.25216	No	No	Yes	Yes	5	8
47	E1x49	E2	cck_off	12.564	3.00863	No	No	Yes	Yes	4	3
48	3x40	6x44	cck_off	10.0146	8.82293	No	No	Yes	No	8	9
49	3x50	3x54	cck_off	14.1321	0	Yes	No	No	No	9	9
50	5x61	6x34	cck_off	34.0579	0	No	No	No	No	9	8
51	3x54	5x61	cck_off	14.4091	1.29376	No	No	No	No	9	9
52	3x54	5x65	cck_off	24.7946	0	No	No	No	No	9	9
53	E2	E2x52	cck_off	63.7964	1.28361	Yes	Yes	Yes	Yes	3	5
54	4x61	E2x52	cck_off	41.8517	1.03501	Yes	Yes	Yes	Yes	7	5
55	5x36	E2	cck_off	42.6734	4.86555	No	No	Yes	Yes	5	3
56	5x32	5x35	cck_off	12.8973	9.64485	No	No	No	No	5	4
57	5x36	5x40	cck_off	38.4478	3.25216	No	No	No	No	5	6
58	5x40	6x59	cck_off	29.9685	1.62861	No	No	No	No	6	6
59	5x37	6x59	cck_off	25.7148	0	No	No	No	No	4	6
60	5x37	6x60	cck_off	21.4517	3.25216	No	No	No	No	4	5
61	5x43	6x52	cck_off	21.7757	0	No	No	Yes	Yes	7	7
62	5x65	6x31	cck_off	19.292	0	No	No	No	No	9	6
63	6x28	6x31	cck_off	16.0993	0	No	No	No	No	5	6
64	6x40	7x49	cck_off	17.029	0	No	No	Yes	No	9	9
65	6x36	6x40	cck_off	13.1837	0	No	No	No	No	9	9
66	5x41	6x60	cck_off	17.1792	1.62861	No	No	No	No	6	5
67	6x36	7x56	cck_off	11.2447	2.94774	No	No	No	No	9	7
68	5x41	5x45	cck_off	12.8973	0	No	No	No	No	6	3
69	2x53	7x42	cck_off	34.9124	0	Yes	No	Yes	Yes	8	7
70	2x49	3x39	cck_off	19.5267	1.49163	No	No	No	No	8	9
71	2x53	6x48	cck_off	23.0433	0	Yes	No	Yes	Yes	8	8
72	6x58	Lig	cck_off	41.9222	1.3242	No	No	Yes	Yes	4	0
73	6x58	E2x51	cck_off	40.9644	0	No	No	No	No	4	4
74	5x39	5x43	cck_off	20.4564	2.86657	Yes	Yes	No	No	8	7
75	5x39	E2x52	cck_off	23.325	0	Yes	Yes	Yes	Yes	8	5
76	E3	Lig	Shared	56.2749	13.9269	Yes	Yes	Yes	Yes	3	0
77	2x57	7x42	Shared	84.8444	33.105	No	No	Yes	Yes	7	7
78	1x39	7x39	Shared	12.5076	21.101	No	No	No	No	7	7
79	6x48	6x52	Shared	79.2901	22.8615	Yes	Yes	Yes	Yes	8	7
80	6x44	6x48	Shared	100	99.4064	Yes	No	Yes	Yes	9	8
81	2x53	3x35	Shared	50.0493	13.1913	Yes	No	No	No	8	6
82	3x47	5x54	Shared	64.4162	99.9087	No	No	No	No	9	8
83	3x47	5x58	Shared	62.4442	100	No	No	Yes	Yes	9	9
84	2x42	4x46	Shared	36.9501	10.1979	Yes	Yes	No	No	8	7
85	2x42	3x46	Shared	11.1789	49.4165	Yes	Yes	No	No	8	9
86	5x58	6x37	Shared	12.5968	47.174	Yes	Yes	No	Yes	9	8
87	2x42	4x45	Shared	23.433	13.8255	Yes	Yes	No	No	8	6
88	4x61	Lig	Shared	50.5235	20.0761	Yes	Yes	Yes	Yes	7	0
89	3x51	5x61	Shared	19.9962	18.346	Yes	Yes	No	No	8	9
90	4x41	4x45	Shared	20.5362	12.481	Yes	Yes	No	No	7	6
91	5x35	E2	Shared	17.1792	12.7803	No	No	Yes	Yes	4	3
92	1x42	2x57	cck_on	0	28.0213	No	No	No	No	7	7
93	1x42	7x39	cck_on	5.02841	24.5814	No	No	No	No	7	7
94	1x39	7x35	cck_on	0	14.0183	No	No	No	No	7	5
95	1x35	7x35	cck_on	5.02841	12.207	No	No	No	No	4	5
96	3x36	Lig	cck_on	0	68.1279	No	No	Yes	Yes	7	0
97	3x36	6x48	cck_on	1.12212	68.5033	No	No	Yes	Yes	7	8
98	5x54	6x44	cck_on	0	99.8681	No	No	Yes	No	8	9
99	3x50	5x58	cck_on	0	94.1755	Yes	No	Yes	Yes	9	9
100	3x50	7x53	cck_on	0	59.0817	Yes	No	No	Yes	9	9
101	3x43	7x53	cck_on	0	23.8052	No	No	No	Yes	8	9
102	3x43	7x49	cck_on	0	22.5622	No	No	Yes	No	8	9
103	2x50	7x49	cck_on	0	19.8123	No	Yes	Yes	No	9	9
104	2x50	7x46	cck_on	2.51186	10.1877	No	Yes	No	No	9	9
105	2x43	7x53	cck_on	5.92986	44.6017	No	No	No	Yes	8	9
106	2x43	7x54	cck_on	0	43.4297	No	No	No	No	8	8
107	1x53	7x54	cck_on	0	25.6672	No	Yes	No	No	9	8
108	7x54	8x50	cck_on	0	18.1076	No	No	No	Yes	8	0
109	1x53	1x57	cck_on	0	15.8549	No	Yes	No	No	9	7
110	1x57	2x40	cck_on	0	11.5728	No	No	No	No	7	9
111	3x46	3x50	cck_on	0	34.7489	No	No	Yes	No	9	9
112	2x42	3x49	cck_on	0	23.4094	Yes	Yes	No	Yes	8	9
113	5x461	6x52	cck_on	0	11.446	No	No	Yes	Yes	7	7
114	3x37	5x461	cck_on	0	10.4313	No	No	No	No	7	7
115	2x53	2x56	cck_on	0	14.6068	Yes	No	No	No	8	7
116	2x52	3x35	cck_on	0	11.7656	No	No	No	No	7	6
117	2x52	3x31	cck_on	9.62486	10.3298	No	No	Yes	Yes	7	5
118	E2	Lig	cck_on	0	48.8737	Yes	Yes	Yes	Yes	3	0
119	E1x52	E2	cck_on	0	18.4678	Yes	Yes	Yes	Yes	6	3
120	5x61	6x37	cck_on	0	20.8473	No	No	No	Yes	9	8
121	3x49	4x41	cck_on	0	12.3389	No	Yes	Yes	Yes	9	7
122	4x38	4x41	cck_on	8.85488	14.3785	No	No	Yes	Yes	8	7
123	4x38	4x40	cck_on	2.95789	11.5221	No	No	No	No	8	5
124	5x47	6x52	cck_on	6.43692	11.4307	No	Yes	Yes	Yes	8	7
125	6x33	6x37	cck_on	1.46016	21.9685	No	No	No	Yes	9	8
126	5x65	6x33	cck_on	0	20.8574	No	No	No	No	9	9
127	5x65	6x30	cck_on	2.67149	19.7007	No	No	No	Yes	9	8
128	6x26	6x30	cck_on	0	10.898	No	No	No	Yes	4	8
129	6x40	7x53	cck_on	0	18.4526	No	No	No	Yes	9	9
130	6x40	7x52	cck_on	1.98131	17.1537	No	No	No	No	9	9
131	7x41	7x42	cck_on	0	31.4764	No	No	Yes	Yes	7	7
132	6x48	7x41	cck_on	4.7514	34.1299	Yes	Yes	No	No	8	7
133	2x56	7x42	cck_on	2.51655	11.8265	No	No	Yes	Yes	7	7
134	3x46	7x53	cck_on	0	15.5708	No	No	No	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	3x32	cck_off	4.24	0	1	0	2	1
2x53	6x48	cck_off	3.99	0	1	0	2	2
2x53	7x42	cck_off	5.275	0	1	0	2	2
2x56	7x42	Shared	4.03	6.60917	0	0	2	2
2x60	7x38	cck_off	8.235	0	0	1	1	1
2x60	7x42	Shared	11.05	5.32417	0	1	1	2
2x60	Lig	Shared	5.035	3.72167	0	1	1	0
2x64	7x35	cck_off	3.725	0	0	0	1	2
2x67	E2	Shared	8.62	2.92	0	0	2	1
E1x49	E2	Shared	8.235	3.34083	1	1	2	1
E1x50	E1x52	Shared	4.825	13.2208	1	1	2	2
E1x50	E2	cck_off	4.26	0	1	1	2	1
3x22	E2	Shared	3.75	3.24167	0	1	2	1
3x26	E2	cck_off	4.9	0	0	0	2	1
3x29	4x61	Shared	6.865	5.03083	1	1	1	1
3x29	4x65	Shared	7.195	4.66333	1	1	1	2
3x29	Lig	cck_off	4.555	0	1	1	1	0
3x32	7x42	cck_off	7.185	0	1	1	1	2
3x32	Lig	Shared	13.675	6.87	1	1	1	0
3x36	6x48	Shared	7.97	6.53833	1	1	1	2
3x36	6x52	cck_off	7.21	0	1	1	1	1
4x57	4x61	Shared	4.19	5.0875	0	0	2	1
4x61	E2x52	Shared	20.115	6.4175	1	1	1	1
4x61	5x39	Shared	12.06	4.82333	1	1	1	2
4x61	Lig	Shared	6.215	13.2908	1	1	1	0
4x64	E2	Shared	16.19	10.3733	1	1	2	1
4x65	E2x52	Shared	4.62	4.41333	0	0	2	1
E2	E2	Shared	49.63	53.495	1	1	1	1
E2	E2x51	Shared	9.965	9.48583	1	1	1	1
6x58	E2x51	cck_off	19.195	0	1	1	1	1
E2x51	E3	cck_off	4.65	0	1	1	1	1
E2	E2x52	Shared	6.7	5.065	1	1	1	1
5x39	E2x52	cck_off	7.02	0	1	1	2	1
5x36	E2	Shared	10.65	5.16333	1	1	2	1
5x35	E2	Shared	11.215	6.26333	1	1	2	1
5x39	5x43	Shared	14.235	14.2375	1	1	2	2
5x43	6x52	cck_off	4.87	0	0	0	2	1
5x47	6x52	Shared	11.785	5.52583	0	0	2	1
6x48	6x52	Shared	4.51	6.0625	1	0	2	1
6x48	7x41	Shared	7.415	6.89833	1	0	2	2
6x51	7x37	Shared	3.68	3.745	0	0	1	2
6x51	7x41	Shared	6.19	3.70333	0	0	1	2
6x51	Lig	cck_off	6.855	0	0	0	1	0
6x52	Lig	cck_off	5.45	0	1	0	1	0
6x55	Lig	Shared	16.355	11.1108	0	0	1	0
6x57	E3	Shared	22.475	18.5708	0	1	2	1
6x58	E3	Shared	8.6	10.9275	1	1	1	1
6x58	Lig	Shared	35.93	20.4567	1	1	1	0
6x61	E3	Shared	13.32	4.35083	0	1	2	1
E3	E3	Shared	16.245	8.7925	1	1	1	1
E3	Lig	Shared	8.765	23.0983	1	1	1	0
7x33	E3	Shared	3.9	3.00833	1	1	2	1
7x34	7x37	Shared	4.42	3.92833	0	1	1	2
7x34	Lig	Shared	19.33	20.89	0	1	1	0
7x31	7x33	cck_off	2.03	0	0	0	2	2
6x54	Lig	cck_off	1.94	0	0	0	1	0
5x44	5x47	cck_off	1.83	0	0	0	2	2
5x33	E3	cck_off	0.725	0	0	0	2	1
2x53	2x56	cck_on	0	3.5675	1	0	2	2
2x56	3x32	cck_on	0	6.345	0	0	2	1
3x36	Lig	cck_on	0	6.49833	1	1	1	0
4x64	E2x52	cck_on	0	9.2825	1	1	2	1
E2	Lig	cck_on	0	11.7292	1	1	1	0
E2x51	Lig	cck_on	0	8.04	1	1	1	0
E2x52	Lig	cck_on	0	9.5	1	1	1	0
5x39	E2	cck_on	0	4.42	1	1	2	1
5x461	6x52	cck_on	0	3.76	0	0	2	1
6x57	6x61	cck_on	0	6.23417	0	1	2	2
7x34	7x38	cck_on	0	3.99083	0	1	1	1
7x38	7x42	cck_on	0	6.44917	0	1	1	2
7x41	7x42	cck_on	0	3.81583	0	0	2	2
E1x52	E2	cck_on	0	3.625	1	1	2	1
3x29	4x64	cck_on	0	6.2425	1	1	1	2
4x61	4x64	cck_on	0	6.4525	1	1	1	2
7x38	Lig	cck_on	0	5.79167	0	1	1	0
5x44	6x52	cck_on	0	2.99667	0	0	2	1
6x62	E3	cck_on	0	2.825	0	0	2	1
3x22	3x26	cck_on	0	2.6475	0	1	2	2
2x64	Lig	cck_on	0	2.3975	0	0	1	0
7x31	E3	cck_on	0	2.16833	0	0	2	1
6x54	E3	cck_on	0	1.44583	0	0	1	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	cck_off	ccka_off
	cck_on	ccka_on cckb_on

Network Difference
Value	cck_off	cck_on
I_min	3.665	3.47
Number of Linked Nodes	243	266
Number of Specific Nodes	2 (0.82%)	25 (9.40%)
Number of Shared Nodes	241 (99.18%)	241 (90.60%)
Number of Links	271	291
Number of Specific Links	114 (42.07%)	134 (46.05%)
Number of Shared Links	157 (57.93%)	157 (53.95%)
Number of Hubs	28	30
Number of Specific Hubs	12 (42.86%)	14 (46.67%)
Number of Shared Hubs	16 (57.14%)	16 (53.33%)
Average % Shared Neighbours (Jaccard)	41.17
Average % Shared Neighbours (Otsuka)	50.17
Average % Shared Neighbours (Overlap Coefficient)	58.91
Average % Shared Cliques (k3-6)	77.17
Graphlets Similarity	0.439371

Paths Difference
Value	cck_off	cck_on
Number Of Nodes in MetaPath	82	58
Specific Nodes in MetaPath	47 (57.32%)	23 (39.66%)
Shared Nodes in MetaPath	241 (99.18%)	241 (99.18%)
Number Of Links MetaPath	91	59
Specific Links in MetaPath	75 (82.42%)	43 (72.88%)
Shared Links in MetaPath	157 (57.93%)	157 (57.93%)
Number of Shortest Paths	61516	43425
Length Of Smallest Path	3	3
Average Path Length	13.6525	12.4902
Length of Longest Path	29	27
Minimum Path Strength	0.7625	0.545
Average Path Strength	7.27332	5.56757
Maximum Path Strength	26.1425	20.8531
Minimum Path Correlation	0.7	0.700833
Average Path Correlation	0.920357	0.916175
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.54545	4.16667
Average % Of Corr. Nodes	45.556	45.2021
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	39.6934	36.0052
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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