psnGPCR

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Orange: nodes, hubs and links specific of ccka_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccka_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ccka_off Int. Strength	ccka_on Int. Strength	ccka_off Hub1?	ccka_on Hub1?	ccka_off Hub2?	ccka_on Hub2?	ConSurf1	ConSurf2
1	1x31	NT.K37	ccka_off	100	0	Yes	No	No	No	1	7
2	1x31	1x32	ccka_off	100	0	Yes	No	No	No	1	4
3	1x43	2x54	ccka_off	100	0	Yes	No	No	No	5	7
4	1x46	1x50	ccka_off	100	0	Yes	No	Yes	No	8	9
5	1x46	7x46	ccka_off	100	0	Yes	No	No	No	8	9
6	1x49	7x50	ccka_off	100	0	No	No	No	No	8	9
7	1x51	2x51	ccka_off	100	0	No	No	No	No	4	7
8	1x53	7x53	ccka_off	100	0	No	Yes	Yes	Yes	9	9
9	1x59	1x60	ccka_off	100	0	No	No	No	No	5	6
10	2x39	3x49	ccka_off	100	0	No	No	No	Yes	8	9
11	2x39	3x50	ccka_off	100	0	No	No	Yes	No	8	9
12	2x40	2x43	ccka_off	100	0	No	No	No	No	9	8
13	2x42	4x45	ccka_off	100	0	Yes	Yes	No	No	8	6
14	2x46	3x39	ccka_off	100	0	No	No	No	No	9	9
15	2x48	4x50	ccka_off	100	0	No	No	Yes	No	6	9
16	2x49	3x35	ccka_off	100	0	No	No	No	No	8	6
17	2x52	4x50	ccka_off	100	0	No	No	Yes	No	7	9
18	2x53	3x32	ccka_off	100	0	Yes	No	No	No	8	7
19	2x53	6x48	ccka_off	100	0	Yes	No	Yes	Yes	8	8
20	2x53	7x42	ccka_off	100	0	Yes	No	Yes	Yes	8	7
21	2x59	3x24	ccka_off	100	0	No	No	No	No	6	5
22	2x60	7x38	ccka_off	100	0	No	No	No	Yes	7	6
23	2x62	E1x52	ccka_off	100	0	No	No	Yes	Yes	5	6
24	2x63	E1x52	ccka_off	100	0	No	No	Yes	Yes	5	6
25	2x64	7x35	ccka_off	100	0	No	No	No	No	6	5
26	2x66	E1x51	ccka_off	100	0	No	No	No	No	4	4
27	E1x49	E2.A193	ccka_off	100	0	No	No	No	No	4	3
28	3x25	E1x50	ccka_off	100	0	No	No	Yes	No	9	8
29	E1x50	E2.L182	ccka_off	100	0	Yes	No	No	No	8	5
30	3x26	E2.N181	ccka_off	100	0	No	No	No	No	5	5
31	3x29	4x65	ccka_off	100	0	No	No	No	No	6	6
32	3x29	Lig	ccka_off	100	0	No	No	Yes	Yes	6	0
33	3x30	4x59	ccka_off	100	0	No	Yes	No	No	6	4
34	3x31	4x54	ccka_off	100	0	Yes	Yes	No	No	5	4
35	3x32	7x42	ccka_off	100	0	No	No	Yes	Yes	7	7
36	3x36	6x52	ccka_off	100	0	No	No	Yes	Yes	7	7
37	3x37	4x53	ccka_off	100	0	No	No	No	No	7	8
38	3x38	4x49	ccka_off	100	0	Yes	Yes	No	No	8	7
39	3x39	6x44	ccka_off	100	0	No	No	Yes	Yes	9	9
40	3x40	3x41	ccka_off	100	0	No	No	No	Yes	8	6
41	3x40	5x461	ccka_off	100	0	No	No	No	No	8	7
42	3x40	6x44	ccka_off	100	0	No	No	Yes	Yes	8	9
43	3x41	3x44	ccka_off	100	0	No	Yes	No	No	6	7
44	3x41	5x50	ccka_off	100	0	No	Yes	No	No	6	9
45	3x43	6x41	ccka_off	100	0	No	No	No	No	8	8
46	3x43	6x44	ccka_off	100	0	No	No	Yes	Yes	8	9
47	3x44	5x54	ccka_off	100	0	No	No	No	No	7	8
48	3x46	6x37	ccka_off	100	0	No	No	No	Yes	9	8
49	3x49	3x50	ccka_off	100	0	No	Yes	Yes	No	9	9
50	3x50	3x53	ccka_off	100	0	Yes	No	No	No	9	8
51	3x50	3x54	ccka_off	100	0	Yes	No	No	No	9	9
52	3x50	6x34	ccka_off	100	0	Yes	No	No	No	9	8
53	3x54	5x65	ccka_off	100	0	No	No	No	No	9	9
54	3x56	I2x53	ccka_off	100	0	Yes	No	No	No	6	8
55	I2x54	I2x57	ccka_off	100	0	No	No	No	Yes	6	7
56	4x41	4x44	ccka_off	100	0	Yes	No	No	No	7	4
57	4x61	5x39	ccka_off	100	0	Yes	Yes	Yes	Yes	7	8
58	4x64	E2.P201	ccka_off	100	0	No	Yes	No	No	5	5
59	E2.M195	E2.V183	ccka_off	100	0	No	No	No	No	4	3
60	E2.A193	E2.F185	ccka_off	100	0	No	No	No	No	3	4
61	6x58	E2x51	ccka_off	100	0	No	No	Yes	No	4	4
62	E2x51	E3.E344	ccka_off	100	0	Yes	No	Yes	No	4	1
63	5x36	E2.L200	ccka_off	100	0	No	No	Yes	Yes	5	4
64	5x35	E2.P201	ccka_off	100	0	No	No	No	No	4	5
65	5x32	5x35	ccka_off	100	0	No	No	No	No	5	4
66	5x43	6x52	ccka_off	100	0	No	No	Yes	Yes	7	7
67	5x461	5x47	ccka_off	100	0	No	No	Yes	Yes	7	8
68	5x54	6x41	ccka_off	100	0	No	No	No	No	8	8
69	5x58	6x34	ccka_off	100	0	Yes	Yes	No	No	9	8
70	5x58	6x38	ccka_off	100	0	Yes	Yes	No	No	9	7
71	5x61	6x34	ccka_off	100	0	No	No	No	No	9	8
72	5x65	6x31	ccka_off	100	0	No	No	No	No	9	6
73	6x27	6x28	ccka_off	100	0	No	No	No	No	4	5
74	6x28	6x31	ccka_off	100	0	No	No	No	No	5	6
75	6x36	6x40	ccka_off	100	0	No	No	No	No	9	9
76	6x36	7x53	ccka_off	100	0	No	No	Yes	Yes	9	9
77	6x40	7x49	ccka_off	100	0	No	No	Yes	No	9	9
78	6x44	6x45	ccka_off	100	0	Yes	Yes	Yes	No	9	6
79	6x45	6x49	ccka_off	100	0	Yes	No	No	No	6	6
80	6x51	7x41	ccka_off	100	0	No	No	No	No	7	7
81	6x51	Lig	ccka_off	100	0	No	No	Yes	Yes	7	0
82	7x48	7x49	ccka_off	100	0	No	No	Yes	No	7	9
83	7x49	7x53	ccka_off	100	0	Yes	No	Yes	Yes	9	9
84	4x39	I1x48	ccka_off	100	0	No	No	No	No	4	7
85	I1x49	I1x50	ccka_off	100	0	No	No	No	No	6	8
86	3x33	4x57	ccka_off	0	0	No	No	No	No	6	8
87	1x38	7x39	ccka_off	50	0	No	No	No	No	5	7
88	3x48	I2x56	ccka_off	50	0	No	No	No	No	6	5
89	1x35	2x65	ccka_off	50	0	No	No	No	No	4	5
90	6x50	7x40	ccka_off	0	0	No	No	No	No	9	8
91	1x54	2x47	ccka_off	0	0	No	No	No	No	7	9
92	E2.A193	E2.K187	ccka_off	0	0	No	No	Yes	No	3	2
93	1x34	1x38	ccka_off	0	0	No	No	No	No	5	5
94	6x42	6x46	ccka_off	0	0	No	No	No	No	6	5
95	5x40	6x56	ccka_off	50	0	No	No	No	No	6	6
96	2x38	I2x57	ccka_off	50	0	No	No	No	Yes	7	7
97	2x42	4x42	ccka_off	0	0	Yes	Yes	No	No	8	7
98	1x48	1x49	ccka_off	0	0	No	No	No	No	4	8
99	5x68	6x27	ccka_off	0	0	No	No	No	No	7	4
100	2x58	2x62	ccka_off	0	0	No	No	No	No	8	5
101	7x51	7x55	ccka_off	0	0	No	No	No	Yes	6	6
102	6x32	7x56	ccka_off	50	0	No	No	No	No	8	7
103	3x26	4x65	ccka_off	0	0	No	No	No	No	5	6
104	1x54	1x58	ccka_off	0	0	No	No	No	No	7	3
105	2x41	4x46	ccka_off	0	0	No	No	No	No	5	7
106	6x32	6x35	ccka_off	50	0	No	No	No	No	8	7
107	1x57	I1x50	ccka_off	0	0	No	No	No	No	7	8
108	8x47	8x48	ccka_off	50	0	No	No	No	No	9	6
109	7x31	7x33	ccka_off	0	0	No	No	No	No	3	4
110	6x54	Lig	ccka_off	0	0	No	No	Yes	Yes	5	0
111	5x44	5x47	ccka_off	0	0	No	No	Yes	Yes	7	8
112	1x49	1x52	ccka_off	0	0	No	No	No	Yes	8	7
113	5x34	5x38	ccka_off	0	0	No	No	No	No	2	4
114	5x62	6x38	ccka_off	0	0	No	No	No	No	6	7
115	5x37	6x59	ccka_off	0	0	No	No	No	No	4	6
116	3x21	E1x52	ccka_off	0	0	No	No	Yes	Yes	7	6
117	1x56	1x60	ccka_off	0	0	No	No	No	No	8	6
118	5x41	5x45	ccka_off	0	0	No	No	No	No	6	3
119	E3.E344	E3.S348	ccka_off	0	0	Yes	No	No	No	1	5
120	E2.K187	E2.N188	ccka_off	0	0	Yes	No	No	No	2	1
121	7x54	7x55	ccka_off	0	0	No	No	No	Yes	8	6
122	1x43	1x44	ccka_off	0	0	Yes	No	No	No	5	4
123	7x47	7x51	ccka_off	0	0	No	No	No	No	7	6
124	I2x50	I2x51	ccka_off	0	0	No	No	No	No	8	7
125	4x38	I2x55	ccka_off	0	0	No	No	No	No	8	5
126	4x51	4x52	ccka_off	0	0	No	No	No	No	4	5
127	E2.T186	E2.T192	ccka_off	0	0	No	No	No	No	3	3
128	1x36	1x40	ccka_off	0	0	No	No	No	No	5	4
129	1x40	1x41	ccka_off	0	0	No	No	No	No	4	4
130	4x52	4x55	ccka_off	0	0	No	No	No	No	5	5
131	5x33	E3.T340	ccka_off	0	0	No	No	No	No	2	2
132	7x56	8x47	ccka_off	0	0	No	No	No	No	7	9
133	1x37	1x38	ccka_off	0	0	No	No	No	No	4	5
134	5x60	5x63	ccka_off	0	0	No	No	No	No	5	4
135	E2.N189	E2.N190	ccka_off	0	0	No	No	No	No	4	4
136	1x30	1x31	Shared	100	100	No	No	Yes	No	1	1
137	1x31	7x32	Shared	100	50	Yes	No	No	Yes	1	3
138	1x35	7x35	Shared	100	100	No	No	No	No	4	5
139	1x36	2x65	Shared	100	100	No	No	No	No	5	5
140	1x39	2x57	Shared	100	100	No	Yes	No	No	7	7
141	1x39	2x61	Shared	100	100	No	Yes	No	No	7	6
142	1x39	7x39	Shared	100	100	No	Yes	No	No	7	7
143	1x42	7x39	Shared	100	100	No	No	No	No	7	7
144	1x42	7x43	Shared	100	0	No	No	No	No	7	5
145	1x43	1x47	Shared	100	100	Yes	No	No	Yes	5	6
146	1x43	2x57	Shared	100	100	Yes	No	No	No	5	7
147	1x45	7x47	Shared	100	0	No	No	No	No	5	7
148	1x46	2x54	Shared	100	100	Yes	No	No	No	8	7
149	1x50	2x50	Shared	100	100	Yes	No	No	Yes	9	9
150	1x50	7x50	Shared	100	100	Yes	No	No	No	9	9
151	1x57	2x44	Shared	100	100	No	No	No	Yes	7	6
152	1x60	I1x50	Shared	100	50	No	No	No	No	6	8
153	I1x48	I1x51	Shared	100	100	No	No	No	No	7	8
154	2x37	2x40	Shared	100	100	No	No	No	No	7	9
155	2x38	3x49	Shared	100	100	No	No	No	Yes	7	9
156	2x41	4x39	Shared	100	0	No	No	No	No	5	4
157	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	8
158	2x42	3x46	Shared	100	100	Yes	Yes	No	No	8	9
159	2x42	4x46	Shared	100	100	Yes	Yes	No	No	8	7
160	2x43	7x53	Shared	100	100	No	No	Yes	Yes	8	9
161	2x45	3x42	Shared	100	100	No	No	No	No	9	8
162	2x45	4x46	Shared	100	100	No	No	No	No	9	7
163	2x45	4x50	Shared	100	100	No	No	Yes	No	9	9
164	2x46	7x49	Shared	100	100	No	No	Yes	No	9	9
165	2x49	3x38	Shared	100	100	No	No	Yes	Yes	8	8
166	2x49	3x39	Shared	100	50	No	No	No	No	8	9
167	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
168	2x51	2x55	Shared	100	0	No	No	No	No	7	5
169	2x52	3x31	Shared	100	100	No	No	Yes	Yes	7	5
170	2x53	3x35	Shared	100	100	Yes	No	No	No	8	6
171	2x551	3x31	Shared	100	100	No	No	Yes	Yes	5	5
172	2x56	7x42	Shared	100	100	No	No	Yes	Yes	7	7
173	2x57	7x42	Shared	100	100	No	No	Yes	Yes	7	7
174	2x59	E1x52	Shared	100	50	No	No	Yes	Yes	6	6
175	2x59	3x28	Shared	100	100	No	No	No	No	6	6
176	2x60	7x42	Shared	100	100	No	No	Yes	Yes	7	7
177	2x60	Lig	Shared	100	100	No	No	Yes	Yes	7	0
178	2x61	2x65	Shared	100	100	No	No	No	No	6	5
179	2x62	2x63	Shared	100	0	No	No	No	No	5	5
180	2x63	E1x50	Shared	100	100	No	No	Yes	No	5	8
181	2x67	E2.K187	Shared	100	100	No	No	Yes	No	4	2
182	E1x49	E1x51	Shared	100	100	No	No	No	No	4	4
183	E1x50	E1x52	Shared	100	100	Yes	No	Yes	Yes	8	6
184	E1x50	E2x50	Shared	100	100	Yes	No	No	No	8	9
185	3x24	E1x52	Shared	100	100	No	No	Yes	Yes	5	6
186	3x22	E2.L182	Shared	100	50	No	No	No	No	4	5
187	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
188	3x29	4x61	Shared	100	100	No	No	Yes	Yes	6	7
189	3x30	4x54	Shared	100	100	No	Yes	No	No	6	4
190	3x30	4x62	Shared	100	100	No	Yes	No	No	6	6
191	3x32	Lig	Shared	100	100	No	No	Yes	Yes	7	0
192	3x34	4x54	Shared	100	100	No	No	No	No	6	4
193	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	8
194	3x38	3x42	Shared	100	100	Yes	Yes	No	No	8	8
195	3x38	4x50	Shared	100	100	Yes	Yes	Yes	No	8	9
196	3x38	4x53	Shared	100	100	Yes	Yes	No	No	8	8
197	3x42	4x49	Shared	100	100	No	No	No	No	8	7
198	3x47	5x54	Shared	100	100	No	Yes	No	No	9	8
199	3x47	5x58	Shared	100	100	No	Yes	Yes	Yes	9	9
200	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	7
201	3x51	3x56	Shared	100	100	Yes	Yes	Yes	No	8	6
202	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	5
203	3x51	5x61	Shared	100	50	Yes	Yes	No	No	8	9
204	3x54	5x61	Shared	100	100	No	No	No	No	9	9
205	3x56	I2x52	Shared	100	50	Yes	No	No	No	6	5
206	4x41	I2x56	Shared	100	100	Yes	No	No	No	7	5
207	4x41	4x45	Shared	100	100	Yes	No	No	No	7	6
208	4x57	4x61	Shared	100	100	No	No	Yes	Yes	8	7
209	4x59	4x60	Shared	100	100	No	No	No	No	4	8
210	4x60	5x39	Shared	100	100	No	No	Yes	Yes	8	8
211	4x61	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	7	5
212	4x61	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
213	4x63	4x64	Shared	100	100	No	No	No	Yes	5	5
214	4x64	E2.L200	Shared	100	100	No	Yes	Yes	Yes	5	4
215	4x65	E2x52	Shared	100	50	No	No	Yes	Yes	6	5
216	E2.L182	E2.N194	Shared	100	50	No	No	No	No	5	3
217	E2.N194	E2.P184	Shared	100	50	No	No	No	No	3	1
218	E2.F185	E2.M195	Shared	100	100	No	No	No	No	4	4
219	E2.L199	E2x51	Shared	100	50	No	No	Yes	No	4	4
220	E2.L200	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	4	5
221	5x39	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	8	5
222	E2.L200	E2.P201	Shared	100	50	Yes	Yes	No	No	4	5
223	5x36	5x40	Shared	100	100	No	No	No	No	5	6
224	5x37	6x60	Shared	100	100	No	No	No	No	4	5
225	5x39	5x42	Shared	100	100	Yes	Yes	No	No	8	5
226	5x39	5x43	Shared	100	100	Yes	Yes	No	No	8	7
227	5x40	6x59	Shared	100	100	No	No	No	No	6	6
228	5x42	5x46	Shared	100	100	No	No	No	No	5	5
229	5x47	6x45	Shared	100	100	Yes	Yes	Yes	No	8	6
230	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
231	5x51	6x45	Shared	100	50	No	No	Yes	No	6	6
232	5x58	6x37	Shared	100	100	Yes	Yes	No	Yes	9	8
233	5x69	6x27	Shared	100	100	No	Yes	No	No	5	4
234	6x36	7x56	Shared	100	100	No	No	No	No	9	7
235	6x40	7x52	Shared	100	100	No	No	No	Yes	9	9
236	6x43	7x48	Shared	100	50	No	Yes	No	No	6	7
237	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
238	6x47	7x45	Shared	100	100	No	No	No	No	8	9
239	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
240	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
241	6x48	7x45	Shared	100	100	Yes	Yes	No	No	8	9
242	6x50	7x37	Shared	100	50	No	No	No	No	9	6
243	6x51	7x37	Shared	100	100	No	No	No	No	7	6
244	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
245	6x55	Lig	Shared	100	100	No	No	Yes	Yes	7	0
246	6x57	E3.S342	Shared	100	100	Yes	Yes	No	No	5	4
247	6x57	E3.A343	Shared	100	100	Yes	Yes	No	No	5	4
248	6x57	E3.R346	Shared	100	50	Yes	Yes	No	No	5	4
249	6x57	E3.L347	Shared	100	100	Yes	Yes	No	No	5	5
250	6x58	E3.E344	Shared	100	100	No	No	Yes	No	4	1
251	6x58	Lig	Shared	100	100	No	No	Yes	Yes	4	0
252	6x61	E3.S342	Shared	100	100	No	No	No	No	4	4
253	E3.E344	E3.T340	Shared	100	100	Yes	No	No	No	1	2
254	E3.R345	E3.S342	Shared	100	50	No	No	No	No	5	4
255	E3.L347	Lig	Shared	100	100	No	No	Yes	Yes	5	0
256	7x32	7x33	Shared	100	0	No	Yes	No	No	3	4
257	7x34	7x37	Shared	100	100	No	No	No	No	5	6
258	7x34	Lig	Shared	100	100	No	No	Yes	Yes	5	0
259	E1x51	E1x52	Shared	100	100	No	No	Yes	Yes	4	6
260	1x46	7x47	Shared	0	50	Yes	No	No	No	8	7
261	4x38	4x41	Shared	50	0	No	No	Yes	No	8	7
262	3x47	5x57	Shared	0	0	No	Yes	No	No	9	6
263	5x49	5x50	Shared	0	0	No	No	No	No	6	9
264	3x27	3x31	Shared	50	100	No	No	Yes	Yes	4	5
265	7x32	7x36	Shared	50	50	No	Yes	No	No	3	4
266	6x24	6x28	Shared	0	0	No	No	No	No	4	5
267	3x44	5x53	Shared	50	0	No	No	No	No	7	7
268	5x41	6x60	Shared	50	100	No	No	No	No	6	5
269	E2.M195	E2x51	Shared	50	100	No	No	Yes	No	4	4
270	1x30	1x34	Shared	50	50	No	No	No	No	1	5
271	3x55	5x64	Shared	0	100	No	No	No	No	7	6
272	6x39	6x43	Shared	0	100	No	No	No	Yes	7	6
273	4x56	4x57	Shared	50	100	No	No	No	No	6	8
274	3x51	3x52	Shared	0	50	Yes	Yes	No	No	8	6
275	1x54	2x44	Shared	50	50	No	No	No	Yes	7	6
276	5x65	6x30	Shared	50	50	No	No	No	Yes	9	8
277	1x50	2x51	Shared	50	100	Yes	No	No	No	9	7
278	1x53	2x47	Shared	0	0	No	Yes	No	No	9	9
279	4x38	4x40	Shared	0	100	No	No	No	No	8	5
280	1x32	NT.E38	Shared	50	50	No	No	No	No	4	3
281	5x56	5x60	Shared	0	0	No	No	No	No	5	5
282	6x33	6x37	Shared	0	0	No	No	No	Yes	9	8
283	5x32	5x34	Shared	0	50	No	No	No	No	5	2
284	5x45	5x48	Shared	50	50	No	No	No	No	3	6
285	5x59	5x62	Shared	0	50	No	No	No	No	1	6
286	3x56	I2x50	Shared	0	0	Yes	No	No	No	6	8
287	6x38	6x42	Shared	0	0	No	No	No	No	7	6
288	6x61	E3.A341	Shared	0	0	No	No	No	No	4	1
289	6x49	6x53	Shared	0	0	No	No	No	No	6	6
290	E2.K187	E2.Q191	Shared	0	50	Yes	No	No	No	2	2
291	2x41	4x43	Shared	0	50	No	No	No	No	5	5
292	5x48	5x52	Shared	0	50	No	No	No	No	6	4
293	6x29	6x32	Shared	0	0	No	No	No	No	6	8
294	1x39	7x35	ccka_on	0	100	No	Yes	No	No	7	5
295	1x41	1x45	ccka_on	0	100	No	No	No	No	4	5
296	1x47	2x51	ccka_on	0	100	No	Yes	No	No	6	7
297	1x53	7x54	ccka_on	0	100	No	Yes	No	No	9	8
298	1x53	7x55	ccka_on	0	100	No	Yes	No	Yes	9	6
299	1x53	8x50	ccka_on	0	100	No	Yes	No	Yes	9	0
300	1x56	8x50	ccka_on	0	100	No	No	No	Yes	8	0
301	1x56	8x57	ccka_on	0	100	No	No	No	No	8	0
302	1x57	2x40	ccka_on	0	100	No	No	No	No	7	9
303	1x58	2x44	ccka_on	0	100	No	No	No	Yes	3	6
304	1x60	I1x49	ccka_on	0	100	No	No	No	No	6	6
305	2x40	I1x50	ccka_on	0	100	No	No	No	No	9	8
306	2x37	2x39	ccka_on	0	100	No	No	No	No	7	8
307	2x38	4x42	ccka_on	0	100	No	No	No	No	7	7
308	2x42	3x49	ccka_on	0	100	Yes	Yes	No	Yes	8	9
309	2x43	7x54	ccka_on	0	100	No	No	No	No	8	8
310	2x46	2x50	ccka_on	0	100	No	No	No	Yes	9	9
311	2x46	3x43	ccka_on	0	100	No	No	No	No	9	8
312	2x50	7x49	ccka_on	0	100	No	Yes	Yes	No	9	9
313	2x52	2x551	ccka_on	0	100	No	No	No	No	7	5
314	2x52	3x35	ccka_on	0	100	No	No	No	No	7	6
315	2x53	2x56	ccka_on	0	100	Yes	No	No	No	8	7
316	2x56	3x32	ccka_on	0	100	No	No	No	No	7	7
317	2x58	2x59	ccka_on	0	100	No	No	No	No	8	6
318	2x60	3x32	ccka_on	0	100	No	No	No	No	7	7
319	2x66	E1x49	ccka_on	0	100	No	No	No	No	4	4
320	3x30	3x31	ccka_on	0	100	No	Yes	Yes	Yes	6	5
321	3x30	3x34	ccka_on	0	100	No	Yes	No	No	6	6
322	3x33	4x61	ccka_on	0	100	No	No	Yes	Yes	6	7
323	3x34	4x57	ccka_on	0	100	No	No	No	No	6	8
324	3x37	3x41	ccka_on	0	100	No	No	No	Yes	7	6
325	3x37	5x461	ccka_on	0	100	No	No	No	No	7	7
326	3x41	4x49	ccka_on	0	100	No	Yes	No	No	6	7
327	3x41	5x461	ccka_on	0	100	No	Yes	No	No	6	7
328	3x43	7x49	ccka_on	0	100	No	No	Yes	No	8	9
329	3x43	7x53	ccka_on	0	100	No	No	Yes	Yes	8	9
330	3x46	3x50	ccka_on	0	100	No	No	Yes	No	9	9
331	3x46	7x53	ccka_on	0	100	No	No	Yes	Yes	9	9
332	3x48	5x53	ccka_on	0	100	No	No	No	No	6	7
333	3x49	I2x56	ccka_on	0	100	No	Yes	No	No	9	5
334	3x49	I2x57	ccka_on	0	100	No	Yes	No	Yes	9	7
335	3x50	5x58	ccka_on	0	100	Yes	No	Yes	Yes	9	9
336	3x50	7x53	ccka_on	0	100	Yes	No	Yes	Yes	9	9
337	I2x53	I2x57	ccka_on	0	100	No	No	No	Yes	8	7
338	I2x56	I2x57	ccka_on	0	100	No	No	No	Yes	5	7
339	4x50	4x54	ccka_on	0	100	Yes	No	No	No	9	4
340	4x64	E2x52	ccka_on	0	100	No	Yes	Yes	Yes	5	5
341	E2x51	Lig	ccka_on	0	100	Yes	No	Yes	Yes	4	0
342	E2x52	Lig	ccka_on	0	100	Yes	Yes	Yes	Yes	5	0
343	5x35	E2.L200	ccka_on	0	100	No	No	Yes	Yes	4	4
344	5x34	5x37	ccka_on	0	100	No	No	No	No	2	4
345	5x44	6x52	ccka_on	0	100	No	No	Yes	Yes	7	7
346	5x47	6x44	ccka_on	0	100	Yes	Yes	Yes	Yes	8	9
347	5x47	6x49	ccka_on	0	100	Yes	Yes	No	No	8	6
348	5x54	6x44	ccka_on	0	100	No	No	Yes	Yes	8	9
349	5x58	6x40	ccka_on	0	100	Yes	Yes	No	No	9	9
350	5x58	6x41	ccka_on	0	100	Yes	Yes	No	No	9	8
351	5x61	6x37	ccka_on	0	100	No	No	No	Yes	9	8
352	5x62	6x34	ccka_on	0	100	No	No	No	No	6	8
353	5x62	6x37	ccka_on	0	100	No	No	No	Yes	6	8
354	5x65	6x34	ccka_on	0	100	No	No	No	No	9	8
355	5x66	5x70	ccka_on	0	100	No	No	No	No	6	0
356	5x72	I3.S300	ccka_on	0	100	No	No	No	No	0	0
357	6x26	6x30	ccka_on	0	100	No	No	No	Yes	4	8
358	6x28	6x32	ccka_on	0	100	No	No	No	No	5	8
359	6x36	7x52	ccka_on	0	100	No	No	No	Yes	9	9
360	6x40	7x53	ccka_on	0	100	No	No	Yes	Yes	9	9
361	6x51	6x55	ccka_on	0	100	No	No	No	No	7	7
362	6x51	7x38	ccka_on	0	100	No	No	No	Yes	7	6
363	6x57	6x61	ccka_on	0	100	Yes	Yes	No	No	5	4
364	E3.E344	Lig	ccka_on	0	100	Yes	No	Yes	Yes	1	0
365	E3.S348	Lig	ccka_on	0	100	No	No	Yes	Yes	5	0
366	7x34	7x38	ccka_on	0	100	No	No	No	Yes	5	6
367	7x38	7x42	ccka_on	0	100	No	Yes	Yes	Yes	6	7
368	7x41	7x42	ccka_on	0	100	No	No	Yes	Yes	7	7
369	7x52	7x53	ccka_on	0	100	No	Yes	Yes	Yes	9	9
370	7x54	8x50	ccka_on	0	100	No	No	No	Yes	8	0
371	7x55	8x50	ccka_on	0	100	No	Yes	No	Yes	6	0
372	8x52	8x55	ccka_on	0	100	No	Yes	No	No	0	0
373	Lig	Lig	ccka_on	0	100	Yes	Yes	Yes	Yes	0	0
374	1x39	2x65	ccka_on	0	100	No	Yes	No	No	7	5
375	1x60	8x52	ccka_on	0	100	No	No	No	Yes	6	0
376	8x55	I1x49	ccka_on	0	100	No	No	No	No	0	6
377	E1x52	E2.N181	ccka_on	0	100	Yes	Yes	No	No	6	5
378	3x29	4x64	ccka_on	0	100	No	No	No	Yes	6	5
379	4x61	4x64	ccka_on	0	100	Yes	Yes	No	Yes	7	5
380	E2.N181	E2.N194	ccka_on	0	100	No	No	No	No	5	3
381	E2.T192	E2.V183	ccka_on	0	100	No	No	No	No	3	3
382	E2.F185	E2.T192	ccka_on	0	100	No	No	No	No	4	3
383	5x63	5x67	ccka_on	0	100	No	No	No	No	4	5
384	7x36	7x40	ccka_on	0	100	No	No	No	No	4	8
385	7x38	Lig	ccka_on	0	100	No	Yes	Yes	Yes	6	0
386	8x47	8x49	ccka_on	0	100	No	No	No	No	9	0
387	8x54	8x58	ccka_on	0	100	No	No	No	No	0	0
388	3x40	5x50	ccka_on	0	0	No	No	No	No	8	9
389	1x48	1x52	ccka_on	0	50	No	No	No	Yes	4	7
390	E1x49	E2.K187	ccka_on	0	50	No	No	Yes	No	4	2
391	1x47	2x54	ccka_on	0	0	No	Yes	No	No	6	7
392	5x40	E2x52	ccka_on	0	50	No	No	Yes	Yes	6	5
393	5x72	6x30	ccka_on	0	50	No	No	No	Yes	0	8
394	5x33	5x37	ccka_on	0	50	No	No	No	No	2	4
395	2x41	4x42	ccka_on	0	50	No	No	No	No	5	7
396	E2x50	Lig	ccka_on	0	50	No	No	Yes	Yes	9	0
397	7x32	E3.R346	ccka_on	0	50	No	Yes	No	No	3	4
398	1x54	2x48	ccka_on	0	0	No	No	No	No	7	6
399	7x48	7x52	ccka_on	0	0	No	No	No	Yes	7	9
400	5x35	5x38	ccka_on	0	50	No	No	No	No	4	4
401	1x52	7x55	ccka_on	0	50	No	Yes	No	Yes	7	6
402	1x52	8x54	ccka_on	0	50	No	Yes	No	No	7	0
403	5x51	6x44	ccka_on	0	50	No	No	Yes	Yes	6	9
404	1x49	7x55	ccka_on	0	0	No	No	No	Yes	8	6
405	1x53	1x57	ccka_on	0	0	No	Yes	No	No	9	7
406	5x65	6x33	ccka_on	0	0	No	No	No	No	9	9
407	5x52	5x55	ccka_on	0	0	No	No	No	No	4	6
408	7x51	7x56	ccka_on	0	0	No	No	No	No	6	7
409	1x38	1x42	ccka_on	0	50	No	No	No	No	5	7
410	5x33	5x35	ccka_on	0	50	No	No	No	No	2	4
411	1x56	8x53	ccka_on	0	50	No	No	No	No	8	0
412	I2x51	I2x52	ccka_on	0	50	No	No	No	No	7	5
413	3x44	5x50	ccka_on	0	50	No	No	No	No	7	9
414	E2.A193	E2.T186	ccka_on	0	50	No	No	No	No	3	3
415	3x41	4x52	ccka_on	0	0	No	Yes	No	No	6	5
416	8x51	8x52	ccka_on	0	50	No	No	No	Yes	0	0
417	1x32	1x35	ccka_on	0	50	No	No	No	No	4	4
418	6x54	E3.L347	ccka_on	0	0	No	No	No	No	5	5
419	3x22	3x26	ccka_on	0	50	No	No	No	No	4	5
420	3x53	I2x57	ccka_on	0	50	No	No	No	Yes	8	7
421	3x47	3x48	ccka_on	0	0	No	Yes	No	No	9	6
422	2x67	E2.T186	ccka_on	0	50	No	No	No	No	4	3
423	6x23	6x26	ccka_on	0	0	No	No	No	No	0	4
424	I3.N299	I3.S298	ccka_on	0	50	No	No	No	No	0	0
425	2x64	Lig	ccka_on	0	0	No	No	Yes	Yes	6	0
426	5x69	5x70	ccka_on	0	0	No	Yes	No	No	5	0
427	5x69	6x30	ccka_on	0	0	No	Yes	No	Yes	5	8
428	5x69	6x31	ccka_on	0	50	No	Yes	No	No	5	6
429	8x53	8x56	ccka_on	0	0	No	No	No	No	0	0
430	5x55	6x45	ccka_on	0	50	No	No	Yes	No	6	6
431	7x31	E3.S348	ccka_on	0	0	No	No	No	No	3	5
432	3x21	3x24	ccka_on	0	50	No	No	No	No	7	5
433	2x44	I1x51	ccka_on	0	50	No	Yes	No	No	6	8
434	5x44	6x56	ccka_on	0	0	No	No	No	No	7	6
435	5x73	6x27	ccka_on	0	0	No	No	No	No	0	4
436	1x51	1x55	ccka_on	0	0	No	No	No	No	4	4
437	5x68	5x71	ccka_on	0	0	No	No	No	No	7	0
438	6x42	6x43	ccka_on	0	0	No	No	No	Yes	6	6
439	1x52	1x55	ccka_on	0	0	No	Yes	No	No	7	4
440	8x48	8x52	ccka_on	0	0	No	No	No	Yes	6	0
441	1x59	8x56	ccka_on	0	0	No	No	No	No	5	0
442	E2.N189	E2.Q191	ccka_on	0	0	No	No	No	No	4	2
443	6x28	6x35	ccka_on	0	0	No	No	No	No	5	7
444	5x71	5x72	ccka_on	0	0	No	No	No	No	0	0
445	6x23	6x25	ccka_on	0	0	No	No	No	No	0	4
446	5x67	5x68	ccka_on	0	0	No	No	No	No	5	7
447	4x55	4x56	ccka_on	0	0	No	No	No	No	5	6
448	1x44	1x47	ccka_on	0	0	No	No	No	Yes	4	6
449	1x34	1x37	ccka_on	0	0	No	No	No	No	5	4
450	6x43	6x46	ccka_on	0	0	No	Yes	No	No	6	5
451	2x43	8x47	ccka_on	0	0	No	No	No	No	8	9
452	5x71	I3.S298	ccka_on	0	0	No	No	No	No	0	0
453	E2.F185	E2.N190	ccka_on	0	0	No	No	No	No	4	4

Orange: nodes, hubs and links specific of ccka_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccka_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	ccka_off Avg Int. Strength	ccka_on Avg Int. Strength	ccka_off Num Of Links	ccka_on Num Of Links	ConSurf
1	1x31	ccka_off	0	0	4	2	1
2	1x43	ccka_off	0	0	4	2	5
3	1x46	ccka_off	0	0	4	2	8
4	1x50	ccka_off	50	50	4	3	9
5	2x53	ccka_off	50	0	4	2	8
6	E1x50	ccka_off	100	50	5	3	8
7	3x50	ccka_off	100	0	5	3	9
8	3x56	ccka_off	0	0	4	3	6
9	4x41	ccka_off	0	0	4	3	7
10	4x50	ccka_off	100	0	4	3	9
11	E2.K187	ccka_off	0	0	4	3	2
12	E2x51	ccka_off	50	50	4	3	4
13	6x45	ccka_off	0	0	4	3	6
14	E3.E344	ccka_off	0	0	4	3	1
15	7x49	ccka_off	50	50	4	3	9
16	2x42	Shared	100	100	5	4	8
17	E1x52	Shared	100	100	7	5	6
18	3x31	Shared	50	50	4	4	5
19	3x38	Shared	100	0	5	4	8
20	3x51	Shared	50	50	5	5	8
21	4x61	Shared	100	100	5	6	7
22	E2x52	Shared	100	100	4	7	5
23	E2.L200	Shared	100	50	4	4	4
24	5x39	Shared	100	50	5	4	8
25	5x47	Shared	50	50	4	4	8
26	5x58	Shared	100	100	4	5	9
27	6x44	Shared	100	0	5	4	9
28	6x48	Shared	100	100	6	5	8
29	6x52	Shared	100	0	5	4	7
30	6x57	Shared	100	50	4	5	5
31	7x42	Shared	100	100	5	5	7
32	7x53	Shared	50	100	4	6	9
33	Lig	Shared	100	100	11	17	0
34	1x39	ccka_on	0	100	3	5	7
35	1x47	ccka_on	0	0	1	4	6
36	1x52	ccka_on	0	0	1	4	7
37	1x53	ccka_on	0	0	2	5	9
38	2x44	ccka_on	0	0	2	4	6
39	2x50	ccka_on	0	50	2	4	9
40	3x30	ccka_on	50	0	3	4	6
41	3x41	ccka_on	0	0	3	4	6
42	3x47	ccka_on	0	0	3	4	9
43	3x49	ccka_on	0	50	3	4	9
44	I2x57	ccka_on	0	50	2	4	7
45	4x64	ccka_on	0	0	3	5	5
46	5x69	ccka_on	0	0	1	4	5
47	6x30	ccka_on	0	0	1	4	8
48	6x37	ccka_on	0	0	3	4	8
49	6x43	ccka_on	0	0	2	4	6
50	7x32	ccka_on	0	0	3	4	3
51	7x38	ccka_on	0	0	1	4	6
52	7x52	ccka_on	0	0	1	4	9
53	7x55	ccka_on	0	0	2	4	6
54	8x50	ccka_on	0	50	0	4	0
55	8x52	ccka_on	0	50	0	4	0

Orange: nodes, hubs and links specific of ccka_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccka_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ccka_off Recurrence	ccka_on Recurrence	ccka_off Hub1?	ccka_on Hub1?	ccka_off Hub2?	ccka_on Hub2?	ConSurf1	ConSurf2
1	1x30	1x31	ccka_off	19.0684	4.20688	No	No	Yes	No	1	1
2	1x30	1x34	ccka_off	21.4029	2.85635	No	No	No	No	1	5
3	1x34	1x38	ccka_off	23.7263	0	No	No	No	No	5	5
4	1x38	7x39	ccka_off	28.3399	0	No	No	No	No	5	7
5	1x39	7x39	ccka_off	35.1773	6.08708	No	Yes	No	No	7	7
6	1x39	2x61	ccka_off	19.0684	1.52246	No	Yes	No	No	7	6
7	2x61	2x65	ccka_off	16.7229	0.00277316	No	No	No	No	6	5
8	1x43	2x54	ccka_off	41.9151	0	Yes	No	No	No	5	7
9	1x46	2x54	ccka_off	39.6803	6.94121	Yes	No	No	No	8	7
10	1x46	7x47	ccka_off	11.9987	5.21353	Yes	No	No	No	8	7
11	1x46	1x50	ccka_off	21.3476	0	Yes	No	Yes	No	8	9
12	2x53	7x42	ccka_off	55.5844	0	Yes	No	Yes	Yes	8	7
13	2x53	3x35	ccka_off	49.7704	2.1076	Yes	No	No	No	8	6
14	2x49	3x35	ccka_off	49.4385	0	No	No	No	No	8	6
15	2x49	3x39	ccka_off	28.7437	1.3117	No	No	No	No	8	9
16	2x46	3x39	ccka_off	65.9899	0	No	No	No	No	9	9
17	2x46	7x49	ccka_off	64.3304	0	No	No	Yes	No	9	9
18	7x49	7x53	ccka_off	41.0909	0	Yes	No	Yes	Yes	9	9
19	1x53	7x53	ccka_off	21.5744	0	No	Yes	Yes	Yes	9	9
20	2x53	6x48	ccka_off	35.1109	0	Yes	No	Yes	Yes	8	8
21	3x39	6x44	ccka_off	52.8628	0	No	No	Yes	Yes	9	9
22	1x53	2x47	ccka_off	19.688	1.91625	No	Yes	No	No	9	9
23	1x54	2x47	ccka_off	17.7684	0	No	No	No	No	7	9
24	1x54	2x44	ccka_off	13.8961	3.82973	No	No	No	Yes	7	6
25	2x49	3x38	ccka_off	54.7049	2.62063	No	No	Yes	Yes	8	8
26	3x38	3x42	ccka_off	23.3833	4.37881	Yes	Yes	No	No	8	8
27	2x45	3x42	ccka_off	22.9131	6.90793	No	No	No	No	9	8
28	2x41	4x46	ccka_off	14.1506	0	No	No	No	No	5	7
29	3x38	4x50	ccka_off	29.0535	6.36439	Yes	Yes	Yes	No	8	9
30	3x43	6x44	ccka_off	59.8883	0	No	No	Yes	Yes	8	9
31	3x43	6x41	ccka_off	58.9091	0	No	No	No	No	8	8
32	5x54	6x41	ccka_off	58.0019	0	No	No	No	No	8	8
33	5x58	6x34	ccka_off	56.641	0	Yes	Yes	No	No	9	8
34	3x50	6x34	ccka_off	23.5493	0	Yes	No	No	No	9	8
35	2x42	4x45	ccka_off	22.7416	0	Yes	Yes	No	No	8	6
36	2x52	4x50	ccka_off	10.9919	0	No	No	Yes	No	7	9
37	3x32	7x42	ccka_off	24.9654	0	No	No	Yes	Yes	7	7
38	6x58	Lig	ccka_off	57.8083	1.34498	No	No	Yes	Yes	4	0
39	6x58	E2x51	ccka_off	49.173	0	No	No	Yes	No	4	4
40	E2.M195	E2x51	ccka_off	46.5287	7.39878	No	No	Yes	No	4	4
41	E2.F185	E2.M195	ccka_off	43.3258	5.92901	No	No	No	No	4	4
42	E2.A193	E2.F185	ccka_off	41.5888	0	No	No	No	No	3	4
43	E1x49	E2.A193	ccka_off	33.2965	0	No	No	No	No	4	3
44	3x32	Lig	ccka_off	46.2466	2.69828	No	No	Yes	Yes	7	0
45	4x60	5x39	ccka_off	11.9987	2.97282	No	No	Yes	Yes	8	8
46	4x59	4x60	ccka_off	10.6102	1.48918	No	No	No	No	4	8
47	3x40	3x41	ccka_off	10.5604	0	No	No	No	Yes	8	6
48	3x50	3x54	ccka_off	13.9072	0	Yes	No	No	No	9	9
49	5x61	6x34	ccka_off	32.9258	0	No	No	No	No	9	8
50	3x54	5x61	ccka_off	14.2336	1.22573	No	No	No	No	9	9
51	3x54	5x65	ccka_off	24.2407	0	No	No	No	No	9	9
52	4x41	4x45	ccka_off	19.9369	0.978924	Yes	No	No	No	7	6
53	4x61	E2x52	ccka_off	33.6948	2.86467	Yes	Yes	Yes	Yes	7	5
54	E2.L200	E2.P201	ccka_off	13.437	1.6223	Yes	Yes	No	No	4	5
55	5x36	E2.L200	ccka_off	26.7135	0	No	No	Yes	Yes	5	4
56	5x35	E2.P201	ccka_off	10.8148	0	No	No	No	No	4	5
57	5x36	5x40	ccka_off	24.0914	1.48918	No	No	No	No	5	6
58	5x40	6x59	ccka_off	18.814	1.48918	No	No	No	No	6	6
59	5x37	6x59	ccka_off	16.1587	0	No	No	No	No	4	6
60	5x37	6x60	ccka_off	13.4923	3.24182	No	No	No	No	4	5
61	5x43	6x52	ccka_off	18.1889	0	No	No	Yes	Yes	7	7
62	5x65	6x31	ccka_off	18.6148	0	No	No	No	No	9	6
63	6x28	6x31	ccka_off	15.5391	0	No	No	No	No	5	6
64	6x40	7x49	ccka_off	16.7948	0	No	No	Yes	No	9	9
65	6x36	6x40	ccka_off	13.0995	0	No	No	No	No	9	9
66	6x36	7x53	ccka_off	13.6085	0	No	No	Yes	Yes	9	9
67	6x36	7x56	ccka_off	22.7084	2.44038	No	No	No	No	9	7
68	5x41	6x60	ccka_off	10.8148	1.6223	No	No	No	No	6	5
69	6x32	7x56	ccka_off	11.3514	0	No	No	No	No	8	7
70	2x53	3x32	ccka_off	22.1442	0	Yes	No	No	No	8	7
71	5x39	5x43	ccka_off	16.1642	1.48918	Yes	Yes	No	No	8	7
72	5x39	E2x52	ccka_off	15.9097	8.7188	Yes	Yes	Yes	Yes	8	5
73	3x46	6x37	ccka_off	11.5948	0	No	No	No	Yes	9	8
74	1x39	2x57	Shared	55.0921	17.6234	No	Yes	No	No	7	7
75	1x43	2x57	Shared	48.5534	17.4653	Yes	No	No	No	5	7
76	2x57	7x42	Shared	100	24.7033	No	No	Yes	Yes	7	7
77	6x44	6x48	Shared	89.7439	52.2962	Yes	Yes	Yes	Yes	9	8
78	1x57	2x44	Shared	11.9434	11.4282	No	No	No	Yes	7	6
79	2x45	4x46	Shared	49.1287	15.8819	No	No	No	No	9	7
80	2x45	4x50	Shared	28.4892	14.5646	No	No	Yes	No	9	9
81	3x47	5x54	Shared	60.187	99.8392	No	Yes	No	No	9	8
82	3x47	5x58	Shared	58.5495	98.7299	No	Yes	Yes	Yes	9	9
83	2x42	4x46	Shared	36.4994	15.9096	Yes	Yes	No	No	8	7
84	2x42	3x46	Shared	12.6957	19.0599	Yes	Yes	No	No	8	9
85	2x60	7x42	Shared	27.0841	10.1913	No	No	Yes	Yes	7	7
86	2x60	Lig	Shared	26.6195	10.7238	No	No	Yes	Yes	7	0
87	E1x49	E1x51	Shared	31.5207	11.6334	No	No	No	No	4	4
88	E1x51	E1x52	Shared	27.925	13.081	No	No	Yes	Yes	4	6
89	E1x50	E1x52	Shared	13.448	29.8946	Yes	No	Yes	Yes	8	6
90	4x61	Lig	Shared	48.4151	19.9251	Yes	Yes	Yes	Yes	7	0
91	6x48	6x52	Shared	57.0117	45.147	Yes	Yes	Yes	Yes	8	7
92	6x52	Lig	Shared	49.173	89.4537	Yes	Yes	Yes	Yes	7	0
93	5x47	6x52	Shared	10.1953	47.5014	Yes	Yes	Yes	Yes	8	7
94	5x58	6x37	Shared	13.885	44.8613	Yes	Yes	No	Yes	9	8
95	3x51	5x61	Shared	19.4446	13.447	Yes	Yes	No	No	8	9
96	E2.L200	E2x52	Shared	47.2921	14.5563	Yes	Yes	Yes	Yes	4	5
97	E3.L347	Lig	Shared	15.2182	24.096	No	No	Yes	Yes	5	0
98	6x57	E3.L347	Shared	13.5089	21.4254	Yes	Yes	No	No	5	5
99	7x32	E3.R346	ccka_on	0	11.4088	No	Yes	No	No	3	4
100	6x57	E3.R346	ccka_on	1.95829	12.8564	Yes	Yes	No	No	5	4
101	7x38	Lig	ccka_on	0	12.0771	No	Yes	Yes	Yes	6	0
102	7x38	7x42	ccka_on	0	11.2562	No	Yes	Yes	Yes	6	7
103	1x43	1x47	ccka_on	2.41744	16.9523	Yes	No	No	Yes	5	6
104	1x47	2x51	ccka_on	0	17.6705	No	Yes	No	No	6	7
105	1x50	2x51	ccka_on	7.23018	18.203	Yes	No	No	No	9	7
106	1x50	2x50	ccka_on	2.45063	18.7854	Yes	No	No	Yes	9	9
107	5x54	6x44	ccka_on	0	100	No	No	Yes	Yes	8	9
108	3x50	5x58	ccka_on	0	47.3294	Yes	No	Yes	Yes	9	9
109	3x50	7x53	ccka_on	0	38.9434	Yes	No	Yes	Yes	9	9
110	2x43	7x53	ccka_on	5.99657	83.0283	No	No	Yes	Yes	8	9
111	2x43	7x54	ccka_on	0	77.9368	No	No	No	No	8	8
112	1x53	7x54	ccka_on	0	51.1675	No	Yes	No	No	9	8
113	5x47	6x44	ccka_on	0	47.3655	Yes	Yes	Yes	Yes	8	9
114	5x58	6x40	ccka_on	0	47.3073	Yes	Yes	No	No	9	9
115	6x40	7x53	ccka_on	0	39.0488	No	No	Yes	Yes	9	9
116	1x53	7x55	ccka_on	0	15.061	No	Yes	No	Yes	9	6
117	7x54	8x50	ccka_on	0	25.0582	No	No	No	Yes	8	0
118	7x55	8x50	ccka_on	0	14.2263	No	Yes	No	Yes	6	0
119	1x53	1x57	ccka_on	0	33.6911	No	Yes	No	No	9	7
120	1x57	2x40	ccka_on	0	20.8014	No	No	No	No	7	9
121	2x40	I1x50	ccka_on	0	15.1941	No	No	No	No	9	8
122	1x60	I1x50	ccka_on	6.0187	13.3139	No	No	No	No	6	8
123	4x57	4x61	ccka_on	5.90253	19.0044	No	No	Yes	Yes	8	7
124	3x34	4x57	ccka_on	0	17.5735	No	No	No	No	6	8
125	3x34	4x54	ccka_on	2.11318	15.1026	No	No	No	No	6	4
126	4x50	4x54	ccka_on	0	17.9035	Yes	No	No	No	9	4
127	2x42	3x49	ccka_on	0	13.0172	Yes	Yes	No	Yes	8	9
128	3x43	7x53	ccka_on	0	21.6057	No	No	Yes	Yes	8	9
129	E2x50	Lig	ccka_on	0	36.4504	No	No	Yes	Yes	9	0
130	E1x50	E2x50	ccka_on	1.94169	33.8658	Yes	No	No	No	8	9
131	5x61	6x37	ccka_on	0	15.9207	No	No	No	Yes	9	8
132	E2x52	Lig	ccka_on	0	29.3289	Yes	Yes	Yes	Yes	5	0
133	E2x51	Lig	ccka_on	0	10.1858	Yes	No	Yes	Yes	4	0
134	5x35	E2.L200	ccka_on	0	12.8425	No	No	Yes	Yes	4	4
135	6x33	6x37	ccka_on	1.5434	25.3106	No	No	No	Yes	9	8
136	5x65	6x33	ccka_on	0	24.1986	No	No	No	No	9	9
137	5x65	6x30	ccka_on	2.80467	23.2085	No	No	No	Yes	9	8
138	5x72	6x30	ccka_on	0	10.1997	No	No	No	Yes	0	8
139	1x52	7x55	ccka_on	0	22.1242	No	Yes	No	Yes	7	6
140	2x46	3x43	ccka_on	0	10.0721	No	No	No	No	9	8
141	3x43	7x49	ccka_on	0	10.0804	No	No	Yes	No	8	9
142	3x46	7x53	ccka_on	0	11.8996	No	No	Yes	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	3x32	ccka_off	4.24	0	1	0	2	1
2x53	6x48	ccka_off	3.99	0	1	0	2	2
2x53	7x42	ccka_off	5.275	0	1	0	2	2
2x56	7x42	Shared	4.03	7.395	0	0	2	2
2x60	7x38	ccka_off	8.235	0	0	1	1	1
2x60	7x42	Shared	11.05	5.235	0	1	1	2
2x60	Lig	Shared	5.035	5.76	0	1	1	0
2x64	7x35	ccka_off	3.725	0	0	0	1	2
3x25	E1x50	ccka_off	4.19	0	2	0	2	2
E1x50	E2x50	Shared	10.475	6.985	2	0	2	1
3x25	E2x50	Shared	7.28	7.28	2	0	2	1
3x29	4x61	Shared	6.865	6.245	1	1	1	1
3x29	4x65	ccka_off	7.195	0	1	1	1	2
3x29	Lig	ccka_off	4.555	0	1	1	1	0
3x32	7x42	ccka_off	7.185	0	1	1	1	2
3x32	Lig	Shared	13.675	5.03	1	1	1	0
3x36	6x48	Shared	7.97	6.13	1	0	2	2
3x36	6x52	ccka_off	7.21	0	1	0	2	1
4x57	4x61	Shared	4.19	6.585	0	0	2	1
4x61	E2x52	Shared	20.115	4.125	1	1	1	1
4x61	5x39	ccka_off	12.06	0	1	1	1	2
4x61	Lig	Shared	6.215	12.665	1	1	1	0
4x64	E2.L200	Shared	6.45	4.105	1	1	2	2
4x65	E2x52	Shared	4.62	1.98	0	0	2	1
E2.L199	E2x51	Shared	4.25	1.82	0	0	2	1
6x58	E2x51	ccka_off	19.195	0	1	1	1	1
E2x51	E3.E344	ccka_off	4.65	0	1	1	1	1
E2.L200	E2x52	Shared	6.7	7.31	1	1	2	1
5x39	E2x52	Shared	7.02	5.515	1	0	2	1
5x39	5x43	Shared	14.235	14.805	1	0	2	2
5x43	6x52	ccka_off	4.87	0	0	0	2	1
5x47	6x52	Shared	11.785	5.895	0	0	2	1
6x48	6x52	Shared	4.51	6.015	1	0	2	1
6x48	7x41	Shared	7.415	5.56	1	0	2	2
6x51	7x37	Shared	3.68	4.42	0	0	1	2
6x51	7x41	ccka_off	6.19	0	0	0	1	2
6x51	Lig	ccka_off	6.855	0	0	0	1	0
6x52	Lig	Shared	5.45	4.29	1	1	1	0
6x55	Lig	Shared	16.355	8.025	0	1	1	0
6x57	E3.L347	Shared	5.69	5.695	0	1	2	1
6x58	E3.E344	Shared	5.235	11.63	1	1	1	1
6x58	Lig	Shared	35.93	23.69	1	1	1	0
E3.E344	E3.T340	Shared	7.055	5.64	1	1	1	2
E3.L347	Lig	Shared	4.73	7.97	0	1	1	0
7x34	7x37	Shared	4.42	4.42	0	1	1	2
7x34	Lig	Shared	19.33	22.99	0	1	1	0
3x33	4x57	ccka_off	3.49	0	0	0	2	2
E2.M195	E2x51	Shared	3.1	10.545	0	0	2	1
6x54	Lig	ccka_off	1.94	0	0	0	1	0
5x44	5x47	ccka_off	1.83	0	0	0	2	2
E3.E344	E3.S348	ccka_off	1.435	0	1	1	1	1
2x53	2x56	ccka_on	0	3.965	1	0	2	2
2x56	3x32	ccka_on	0	5.67	0	0	2	1
2x60	3x32	ccka_on	0	4.91	0	1	1	1
3x33	4x61	ccka_on	0	3.62	0	0	2	1
4x64	E2x52	ccka_on	0	18.565	1	1	2	1
E2x51	Lig	ccka_on	0	14.69	1	1	1	0
E2x52	Lig	ccka_on	0	6.57	1	1	1	0
5x44	6x52	ccka_on	0	3.65	0	0	2	1
6x51	6x55	ccka_on	0	4.245	0	0	1	1
6x51	7x38	ccka_on	0	4.995	0	0	1	1
E3.E344	Lig	ccka_on	0	8.43	1	1	1	0
E3.S348	Lig	ccka_on	0	5.545	0	1	1	0
7x34	7x38	ccka_on	0	3.565	0	1	1	1
7x38	7x42	ccka_on	0	5.275	0	1	1	2
7x41	7x42	ccka_on	0	5.085	0	0	2	2
3x29	4x64	ccka_on	0	12.485	1	1	1	2
4x61	4x64	ccka_on	0	12.905	1	1	1	2
7x38	Lig	ccka_on	0	6.59	0	1	1	0
5x40	E2x52	ccka_on	0	3.395	0	0	2	1
E2x50	Lig	ccka_on	0	3.24	2	1	1	0
6x54	E3.L347	ccka_on	0	2.365	0	0	1	1
2x64	Lig	ccka_on	0	2.205	0	0	1	0
7x31	E3.S348	ccka_on	0	1.86	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	ccka_off	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
	ccka_on	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2

Network Difference
Value	ccka_off	ccka_on
I_min	3.58	3.52
Number of Linked Nodes	269	286
Number of Specific Nodes	7 (2.60%)	24 (8.39%)
Number of Shared Nodes	262 (97.40%)	262 (91.61%)
Number of Links	293	318
Number of Specific Links	135 (46.08%)	160 (50.31%)
Number of Shared Links	158 (53.92%)	158 (49.69%)
Number of Hubs	33	40
Number of Specific Hubs	15 (45.45%)	22 (55.00%)
Number of Shared Hubs	18 (54.55%)	18 (45.00%)
Average % Shared Neighbours (Jaccard)	37.78
Average % Shared Neighbours (Otsuka)	47.21
Average % Shared Neighbours (Overlap Coefficient)	56.29
Average % Shared Cliques (k3-6)	75.00
Graphlets Similarity	0.491999

Paths Difference
Value	ccka_off	ccka_on
Number Of Nodes in MetaPath	91	65
Specific Nodes in MetaPath	48 (52.75%)	22 (33.85%)
Shared Nodes in MetaPath	262 (97.40%)	262 (97.40%)
Number Of Links MetaPath	98	69
Specific Links in MetaPath	73 (74.49%)	44 (63.77%)
Shared Links in MetaPath	158 (53.92%)	158 (53.92%)
Number of Shortest Paths	53002	77199
Length Of Smallest Path	3	3
Average Path Length	13.699	13.5018
Length of Longest Path	29	27
Minimum Path Strength	0.7625	0.915
Average Path Strength	6.98741	5.82478
Maximum Path Strength	26.1425	17.0333
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.925084	0.923632
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.54545	4.7619
Average % Of Corr. Nodes	49.5841	46.4805
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	36.4351	45.7558
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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