psnGPCR

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Orange: nodes, hubs and links specific of ccr2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccr2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ccr2_off Int. Strength	ccr2_on Int. Strength	ccr2_off Hub1?	ccr2_on Hub1?	ccr2_off Hub2?	ccr2_on Hub2?	ConSurf1	ConSurf2
1	1x31	Lig	ccr2_off	6.19	0	No	No	Yes	Yes	3	0
2	1x34	1x35	ccr2_off	4.15	0	No	No	Yes	No	5	6
3	1x35	7x39	ccr2_off	4.42	0	Yes	No	No	No	6	5
4	1x35	Lig	ccr2_off	12.53	0	Yes	No	Yes	Yes	6	0
5	1x38	7x43	ccr2_off	4.42	0	No	No	No	No	5	5
6	1x39	2x57	ccr2_off	7.03	0	Yes	Yes	No	No	7	7
7	1x39	7x39	ccr2_off	6.24	0	Yes	Yes	No	No	7	5
8	1x41	1x45	ccr2_off	4.87	0	No	No	No	No	4	6
9	1x42	7x47	ccr2_off	6.83	0	No	No	No	No	7	8
10	1x47	1x51	ccr2_off	4.98	0	Yes	No	No	No	6	4
11	1x49	7x50	ccr2_off	4.06	0	No	No	No	No	7	9
12	1x53	7x53	ccr2_off	5.05	0	No	No	No	Yes	9	9
13	1x56	8x53	ccr2_off	5.71	0	No	No	No	No	7	5
14	1x60	8x53	ccr2_off	5.86	0	Yes	No	No	No	5	5
15	2x40	I1x48	ccr2_off	9.68	0	Yes	No	No	No	8	6
16	2x44	I1x50	ccr2_off	6.92	0	Yes	Yes	No	No	6	6
17	2x38	4x41	ccr2_off	4.87	0	Yes	Yes	No	No	6	4
18	2x42	3x46	ccr2_off	4.69	0	Yes	Yes	No	No	7	9
19	2x43	3x46	ccr2_off	4.15	0	No	No	No	No	8	9
20	2x50	7x49	ccr2_off	12.12	0	No	No	No	No	9	9
21	2x54	7x46	ccr2_off	4.76	0	No	No	No	No	6	8
22	2x59	E1x52	ccr2_off	17.05	0	No	No	No	No	6	7
23	2x60	E1x50	ccr2_off	4.69	0	Yes	No	Yes	Yes	6	8
24	2x60	7x42	ccr2_off	4.65	0	Yes	No	Yes	Yes	6	7
25	2x62	2x66	ccr2_off	8.93	0	No	No	No	No	4	4
26	2x62	E1x52	ccr2_off	5.66	0	No	No	No	No	4	7
27	E1x50	E1x52	ccr2_off	12.03	0	Yes	Yes	No	No	8	7
28	3x26	E2	ccr2_off	7.18	0	No	No	Yes	Yes	7	3
29	3x32	3x33	ccr2_off	8.71	0	Yes	No	Yes	No	6	5
30	3x32	7x42	ccr2_off	4.79	0	Yes	No	Yes	Yes	6	7
31	3x33	3x37	ccr2_off	5.66	0	Yes	No	Yes	Yes	5	7
32	3x33	4x61	ccr2_off	25.51	0	Yes	No	Yes	No	5	4
33	3x33	Lig	ccr2_off	4.65	0	Yes	No	Yes	Yes	5	0
34	3x36	6x44	ccr2_off	7.94	0	Yes	Yes	Yes	Yes	7	9
35	3x40	5x50	ccr2_off	6.77	0	No	No	Yes	Yes	8	8
36	3x40	6x44	ccr2_off	16.92	0	No	No	Yes	Yes	8	9
37	3x41	4x49	ccr2_off	3.89	0	Yes	No	No	No	5	7
38	3x41	5x46	ccr2_off	4.87	0	Yes	No	No	No	5	4
39	3x43	6x40	ccr2_off	4.42	0	No	No	Yes	No	8	8
40	3x43	6x41	ccr2_off	4.37	0	No	No	No	No	8	8
41	3x46	6x37	ccr2_off	5.71	0	No	No	No	No	9	7
42	3x50	6x30	ccr2_off	9.6	0	Yes	No	No	No	9	5
43	3x51	3x56	ccr2_off	11.98	0	No	No	No	No	8	6
44	3x54	6x31	ccr2_off	7.95	0	No	No	No	No	8	4
45	3x55	5x64	ccr2_off	4.76	0	Yes	No	No	No	7	5
46	4x61	5x39	ccr2_off	8.93	0	Yes	No	No	No	4	5
47	4x64	5x35	ccr2_off	14.03	0	Yes	No	No	No	4	3
48	5x35	5x38	ccr2_off	4.01	0	No	No	No	No	3	4
49	5x36	6x59	ccr2_off	4.39	0	No	No	No	No	3	5
50	5x37	6x60	ccr2_off	8.46	0	No	No	Yes	No	3	4
51	5x40	6x60	ccr2_off	3.89	0	Yes	No	Yes	No	5	4
52	5x43	6x51	ccr2_off	7.2	0	No	Yes	Yes	No	5	6
53	5x43	6x52	ccr2_off	4.82	0	No	Yes	No	No	5	8
54	5x54	6x41	ccr2_off	7.22	0	No	No	No	No	8	8
55	5x58	6x38	ccr2_off	16.5	0	No	Yes	No	No	8	4
56	6x28	6x31	ccr2_off	10.48	0	No	No	No	No	3	4
57	6x29	6x33	ccr2_off	9.68	0	No	No	No	No	4	7
58	6x29	8x48	ccr2_off	10.8	0	No	No	No	No	4	5
59	6x32	8x48	ccr2_off	15.12	0	No	No	No	No	6	5
60	6x38	6x42	ccr2_off	11.3	0	No	No	No	No	4	5
61	6x39	7x52	ccr2_off	6.08	0	No	No	No	No	5	8
62	6x39	7x56	ccr2_off	4.76	0	No	No	No	No	5	6
63	6x40	7x49	ccr2_off	7.08	0	Yes	No	No	No	8	9
64	6x40	7x53	ccr2_off	7.25	0	Yes	No	No	Yes	8	9
65	6x41	6x45	ccr2_off	6.22	0	No	No	Yes	No	8	5
66	6x43	7x52	ccr2_off	4.61	0	No	No	No	No	6	8
67	6x44	6x45	ccr2_off	5.16	0	Yes	Yes	Yes	No	9	5
68	6x47	7x48	ccr2_off	5.02	0	No	Yes	No	No	8	6
69	6x48	6x51	ccr2_off	6.75	0	Yes	Yes	Yes	No	9	6
70	6x54	7x37	ccr2_off	4.76	0	No	No	No	No	5	7
71	6x58	7x30	ccr2_off	4.12	0	No	No	No	No	4	4
72	6x58	7x34	ccr2_off	4.39	0	No	No	No	No	4	4
73	6x59	6x60	ccr2_off	7.78	0	No	No	Yes	No	5	4
74	6x62	6x63	ccr2_off	12.83	0	No	No	No	No	3	1
75	6x64	7x30	ccr2_off	4.87	0	No	Yes	No	No	1	4
76	7x42	Lig	ccr2_off	5.12	0	Yes	Yes	Yes	Yes	7	0
77	7x53	8x49	ccr2_off	5.61	0	No	Yes	No	No	9	6
78	2x39	3x50	ccr2_off	3.88	0	No	No	Yes	No	7	9
79	2x49	3x39	ccr2_off	3.71	0	No	No	No	No	8	9
80	1x47	2x54	ccr2_off	3.65	0	Yes	No	No	No	6	6
81	3x27	3x28	ccr2_off	3.65	0	No	No	Yes	Yes	4	6
82	5x51	6x45	ccr2_off	3.65	0	No	No	Yes	No	6	5
83	8x54	8x58	ccr2_off	3.65	0	No	No	No	No	7	6
84	1x60	8x56	ccr2_off	3.63	0	Yes	No	No	No	5	4
85	3x49	3x50	ccr2_off	3.57	0	No	No	Yes	No	8	9
86	2x41	4x42	ccr2_off	3.53	0	No	No	No	No	7	7
87	6x50	7x37	ccr2_off	3.5	0	No	No	No	No	9	7
88	1x30	Lig	ccr2_off	3.44	0	No	No	Yes	Yes	4	0
89	2x37	2x39	ccr2_off	3.38	0	No	No	No	No	7	7
90	6x32	6x35	ccr2_off	3.2	0	No	No	No	No	6	5
91	1x42	7x43	ccr2_off	3.17	0	No	No	No	No	7	5
92	1x35	2x64	ccr2_off	3.15	0	Yes	No	No	No	6	5
93	2x38	I2x53	ccr2_off	3.15	0	Yes	Yes	No	No	6	5
94	3x55	5x61	ccr2_off	3.07	0	Yes	No	Yes	No	7	8
95	3x52	I2x51	ccr2_off	2.98	0	No	No	No	No	5	5
96	2x38	4x38	ccr2_off	2.95	0	Yes	Yes	No	No	6	7
97	5x40	6x56	ccr2_off	2.95	0	Yes	No	No	No	5	6
98	6x33	6x36	ccr2_off	2.92	0	No	No	No	No	7	8
99	E2	E2x52	ccr2_off	2.89	0	Yes	Yes	No	No	3	4
100	1x27	7x35	ccr2_off	2.87	0	No	Yes	No	No	5	4
101	6x29	I1x48	ccr2_off	2.87	0	No	No	No	No	4	6
102	1x58	2x44	ccr2_off	2.85	0	No	No	Yes	Yes	3	6
103	2x48	2x52	ccr2_off	2.85	0	No	No	No	No	5	7
104	E1x49	E2	ccr2_off	2.85	0	No	No	Yes	Yes	4	3
105	3x48	3x52	ccr2_off	2.85	0	No	No	No	No	6	5
106	1x51	2x51	ccr2_off	2.83	0	No	No	No	No	4	7
107	1x58	1x59	ccr2_off	2.83	0	No	No	No	No	3	4
108	3x21	E1x50	ccr2_off	2.81	0	No	No	Yes	Yes	7	8
109	3x41	4x53	ccr2_off	2.77	0	Yes	No	No	No	5	8
110	7x36	Lig	ccr2_off	2.7	0	No	No	Yes	Yes	5	0
111	6x64	7x26	ccr2_off	2.64	0	No	Yes	No	No	1	1
112	1x60	8x52	ccr2_off	2.54	0	Yes	No	No	No	5	4
113	1x47	2x55	ccr2_off	2.51	0	Yes	No	No	No	6	4
114	5x41	6x60	ccr2_off	2.51	0	No	No	Yes	No	4	4
115	I2x54	I2x57	ccr2_off	2.43	0	No	No	No	Yes	5	7
116	1x36	2x65	ccr2_off	1.87	0	No	No	No	No	5	4
117	6x36	8x47	ccr2_off	1.84	0	No	No	No	No	8	8
118	4x42	4x45	ccr2_off	1.82	0	No	No	No	No	7	5
119	1x32	2x65	ccr2_off	1.79	0	No	No	No	No	7	4
120	3x30	3x34	ccr2_off	1.76	0	No	No	No	No	6	6
121	2x52	3x35	ccr2_off	1.71	0	No	No	No	No	7	8
122	8x58	CT	ccr2_off	1.71	0	No	No	No	No	6	4
123	4x60	4x61	ccr2_off	1.63	0	No	No	Yes	No	7	4
124	4x39	4x40	ccr2_off	1.59	0	No	No	No	No	3	4
125	I2x54	I2x56	ccr2_off	1.58	0	No	No	No	No	5	3
126	3x54	6x34	ccr2_off	1.54	0	No	No	No	No	8	6
127	5x61	6x34	ccr2_off	1.54	0	Yes	No	No	No	8	6
128	1x27	1x28	ccr2_off	1.52	0	No	Yes	No	No	5	5
129	8x47	8x51	ccr2_off	1.5	0	No	No	No	No	8	8
130	5x51	5x55	ccr2_off	1.49	0	No	No	No	No	6	4
131	2x40	I1x51	ccr2_off	1.38	0	Yes	No	No	No	8	6
132	2x62	E1x51	ccr2_off	1.38	0	No	No	No	No	4	3
133	3x50	3x53	ccr2_off	1.38	0	Yes	No	No	No	9	8
134	3x53	6x30	ccr2_off	1.38	0	No	No	No	No	8	5
135	6x61	7x30	ccr2_off	1.33	0	No	Yes	No	No	4	4
136	7x31	7x35	ccr2_off	1.31	0	No	No	No	No	4	4
137	4x40	I2x57	ccr2_off	1.29	0	No	No	No	Yes	4	7
138	4x51	4x55	ccr2_off	1.22	0	No	No	No	No	4	3
139	8x54	8x55	ccr2_off	1.13	0	No	No	No	No	7	5
140	1x27	7x32	Shared	8.6	1.43	No	Yes	No	No	5	1
141	1x35	1x39	Shared	16.41	16.41	Yes	No	Yes	Yes	6	7
142	1x36	1x37	Shared	5.84	5.84	No	No	No	No	5	5
143	1x39	7x42	Shared	11.97	8.38	Yes	Yes	Yes	Yes	7	7
144	1x43	1x47	Shared	6.43	3.22	No	No	Yes	No	7	6
145	1x43	2x58	Shared	10.11	17.34	No	No	No	No	7	9
146	1x50	2x50	Shared	9.42	12.12	No	Yes	No	No	9	9
147	1x50	2x54	Shared	4.12	2.75	No	Yes	No	No	9	6
148	1x50	7x50	Shared	11.4	8.15	No	Yes	No	No	9	9
149	1x54	2x44	Shared	4.47	2.98	No	No	Yes	Yes	8	6
150	1x57	2x40	Shared	4.07	4.07	No	Yes	Yes	No	7	8
151	1x57	2x43	Shared	4.15	4.15	No	Yes	No	No	7	8
152	1x57	2x44	Shared	4.15	4.15	No	Yes	Yes	Yes	7	6
153	2x38	2x42	Shared	7.03	8.21	Yes	Yes	Yes	Yes	6	7
154	2x42	3x45	Shared	7.03	9.38	Yes	Yes	No	Yes	7	6
155	2x42	4x45	Shared	4.99	7.49	Yes	Yes	No	No	7	5
156	2x45	3x42	Shared	16.92	13.29	No	No	Yes	Yes	9	7
157	2x45	4x46	Shared	8.94	8.94	No	No	No	No	9	7
158	2x45	4x50	Shared	10.17	5.65	No	No	Yes	Yes	9	9
159	2x46	3x43	Shared	5.71	4.28	No	No	No	No	9	8
160	2x49	4x50	Shared	4.94	6.18	No	No	Yes	Yes	8	9
161	2x53	3x32	Shared	9.28	12.38	No	Yes	Yes	No	6	6
162	2x53	7x42	Shared	4.98	3.73	No	Yes	Yes	Yes	6	7
163	2x53	7x46	Shared	5.59	4.19	No	Yes	No	No	6	8
164	2x56	2x60	Shared	7.28	7.28	No	Yes	Yes	No	7	6
165	2x56	3x28	Shared	6.49	3.89	No	Yes	Yes	Yes	7	6
166	2x56	3x31	Shared	4.42	2.95	No	Yes	No	No	7	4
167	2x59	3x28	Shared	17.05	10.96	No	No	Yes	Yes	6	6
168	2x60	Lig	Shared	15.8	22.08	Yes	No	Yes	Yes	6	0
169	2x63	E1x50	Shared	6.18	4.94	No	No	Yes	Yes	4	8
170	3x25	E1x50	Shared	3.92	3.92	No	No	Yes	Yes	9	8
171	E1x50	E2	Shared	6.18	5.85	Yes	Yes	Yes	Yes	8	3
172	E1x50	E2x50	Shared	16.98	9.14	Yes	Yes	No	No	8	9
173	3x22	E2	Shared	7.52	3.15	No	No	Yes	Yes	3	3
174	3x24	3x28	Shared	4.98	8.71	No	No	Yes	Yes	5	6
175	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
176	3x29	4x65	Shared	10.99	14.13	No	No	No	No	6	5
177	3x29	Lig	Shared	7.11	12.76	No	No	Yes	Yes	6	0
178	3x32	7x38	Shared	4.49	5.61	Yes	No	No	Yes	6	5
179	3x32	Lig	Shared	7.78	9.74	Yes	No	Yes	Yes	6	0
180	3x33	4x57	Shared	4.18	2.79	Yes	No	No	No	5	7
181	3x34	4x57	Shared	4.64	4.64	No	No	No	No	6	7
182	3x36	3x37	Shared	9.28	5.16	Yes	Yes	Yes	Yes	7	7
183	3x36	5x43	Shared	17.49	13.38	Yes	Yes	No	Yes	7	5
184	3x36	6x48	Shared	15.43	7.72	Yes	Yes	Yes	Yes	7	9
185	3x37	4x56	Shared	6.93	4.16	Yes	Yes	No	No	7	5
186	3x37	5x46	Shared	4.87	4.87	Yes	Yes	No	No	7	4
187	3x41	4x52	Shared	3.93	3.93	Yes	No	No	No	5	4
188	3x42	4x46	Shared	5.28	3.96	Yes	Yes	No	No	7	7
189	3x42	4x49	Shared	14.27	11.67	Yes	Yes	No	No	7	7
190	3x42	4x50	Shared	11.02	10.02	Yes	Yes	Yes	Yes	7	9
191	3x44	5x50	Shared	5.08	6.77	No	Yes	Yes	Yes	8	8
192	3x45	4x49	Shared	4.42	5.9	No	Yes	No	No	6	7
193	3x47	5x58	Shared	12.48	3.75	No	Yes	No	Yes	9	8
194	3x51	3x55	Shared	12.62	12.62	No	No	Yes	No	8	7
195	3x51	5x57	Shared	9.41	9.41	No	No	No	No	8	7
196	3x55	3x56	Shared	4.15	9.69	Yes	No	No	No	7	6
197	4x41	4x45	Shared	10.38	7.78	No	No	No	No	4	5
198	4x61	E2	Shared	6.04	3.01	Yes	No	Yes	Yes	4	3
199	4x63	4x64	Shared	7.54	1.26	No	No	Yes	No	5	4
200	4x64	E2	Shared	16.08	7.5	Yes	No	Yes	Yes	4	3
201	4x64	5x32	Shared	8.67	10.11	Yes	No	No	No	4	4
202	E2	E2	Shared	41	48.58	Yes	Yes	Yes	Yes	3	3
203	E2x51	E2x52	Shared	4.06	4.06	No	No	No	No	4	4
204	5x36	E2	Shared	4.83	6.04	No	No	Yes	Yes	3	3
205	5x39	E2	Shared	4.53	12.44	No	No	Yes	Yes	5	3
206	5x32	5x35	Shared	4.05	12.16	No	No	No	No	4	3
207	5x33	5x37	Shared	8.44	2.41	No	No	No	No	3	3
208	5x40	6x55	Shared	4.56	4.56	Yes	No	No	No	5	6
209	5x40	6x59	Shared	14.13	14.13	Yes	No	No	No	5	5
210	5x42	5x46	Shared	5.65	2.83	No	No	No	No	4	4
211	5x44	6x56	Shared	10.98	5.49	No	No	No	No	5	6
212	5x461	5x50	Shared	4.06	4.06	No	No	Yes	Yes	6	8
213	5x47	6x49	Shared	4.42	5.9	No	No	Yes	Yes	8	5
214	5x47	6x52	Shared	4.12	9.61	No	No	No	No	8	8
215	5x58	6x37	Shared	6.04	7.25	No	Yes	No	No	8	7
216	5x61	5x65	Shared	4.28	2.85	Yes	No	No	No	8	8
217	6x40	7x52	Shared	10.3	2.94	Yes	No	No	No	8	8
218	6x44	6x48	Shared	12.54	12.54	Yes	Yes	Yes	Yes	9	9
219	6x44	7x45	Shared	5.44	5.44	Yes	Yes	No	Yes	9	9
220	6x45	6x49	Shared	3.89	16.86	Yes	No	Yes	Yes	5	5
221	6x47	7x45	Shared	11.31	9.05	No	Yes	No	Yes	8	9
222	6x48	7x41	Shared	11.26	5.63	Yes	Yes	No	No	9	8
223	6x48	7x45	Shared	7.41	17.98	Yes	Yes	No	Yes	9	9
224	6x51	6x55	Shared	8.46	10.88	Yes	No	No	No	6	6
225	6x51	7x37	Shared	6.24	8.74	Yes	No	No	No	6	7
226	6x51	7x38	Shared	8.98	11.22	Yes	No	No	Yes	6	5
227	6x54	7x34	Shared	4.76	3.17	No	No	No	No	5	4
228	6x61	7x27	Shared	8.5	2.83	No	Yes	No	No	4	2
229	7x35	Lig	Shared	11.24	3.03	No	No	Yes	Yes	4	0
230	7x38	Lig	Shared	17.59	6.29	No	Yes	Yes	Yes	5	0
231	1x36	2x64	Shared	3.74	3.74	No	No	No	No	5	5
232	5x59	5x60	Shared	3.71	1.86	No	No	No	No	4	4
233	1x60	I1x48	Shared	3.58	1.62	Yes	No	No	No	5	6
234	3x30	4x62	Shared	3.53	3.53	No	No	No	No	6	5
235	4x59	4x60	Shared	3.53	3.53	No	No	No	No	5	7
236	2x48	4x50	Shared	3.52	3.52	No	No	Yes	Yes	5	9
237	6x49	6x50	Shared	3.5	3.5	Yes	Yes	No	No	5	9
238	5x60	5x63	Shared	3.49	1.74	No	No	No	No	4	4
239	1x53	2x47	Shared	3.39	1.7	No	No	No	No	9	9
240	3x47	5x57	Shared	3.38	3.38	No	Yes	No	No	9	7
241	2x37	2x40	Shared	3.11	7.78	No	No	Yes	No	7	8
242	3x34	4x54	Shared	3.07	3.07	No	No	No	No	6	4
243	6x49	6x53	Shared	3.04	3.04	Yes	Yes	No	No	5	6
244	1x42	2x57	Shared	2.98	2.98	No	No	No	No	7	7
245	3x44	3x48	Shared	2.94	2.94	No	Yes	No	No	8	6
246	3x44	5x53	Shared	2.94	4.42	No	Yes	No	Yes	8	6
247	3x54	5x61	Shared	2.94	7.36	No	No	Yes	No	8	8
248	1x39	2x61	Shared	2.67	2.67	Yes	Yes	No	No	7	7
249	1x29	1x33	Shared	2.56	5.12	No	No	No	No	4	5
250	7x51	7x55	Shared	2.51	3.77	No	No	No	No	7	7
251	6x47	7x40	Shared	2.44	7.31	No	Yes	No	No	8	7
252	6x57	6x64	Shared	2.44	2.44	No	No	No	Yes	4	1
253	3x38	3x39	Shared	2.11	2.11	No	No	No	No	7	9
254	1x46	7x47	Shared	1.96	3.92	No	No	No	No	8	8
255	1x48	1x49	Shared	1.84	1.84	No	No	No	No	4	7
256	3x55	5x60	Shared	1.84	1.84	Yes	No	No	No	7	4
257	6x54	7x33	Shared	1.7	3.39	No	No	No	No	5	5
258	5x49	5x50	Shared	1.64	3.28	No	No	Yes	Yes	6	8
259	4x44	4x48	Shared	1.54	1.54	No	No	No	No	3	4
260	1x45	1x46	Shared	1.51	1.51	No	No	No	No	6	8
261	4x47	4x51	Shared	1.49	1.49	No	No	No	No	4	4
262	5x41	5x45	Shared	1.47	2.94	No	No	No	No	4	4
263	5x52	5x56	Shared	1.43	5.71	No	No	No	No	4	4
264	6x42	6x46	Shared	1.43	2.85	No	No	No	No	5	6
265	1x51	1x55	Shared	1.41	5.65	No	No	No	No	4	3
266	Lig	NT	ccr2_on	0	23.95	Yes	Yes	No	Yes	0	0
267	NT	NT	ccr2_on	0	12.28	No	Yes	No	Yes	0	0
268	E3	NT	ccr2_on	0	7.28	No	Yes	No	Yes	0	0
269	1x27	NT	ccr2_on	0	5.76	No	Yes	No	Yes	5	0
270	7x31	NT	ccr2_on	0	5.04	No	No	No	Yes	4	0
271	1x27	7x28	ccr2_on	0	3.23	No	Yes	No	No	5	3
272	1x27	7x31	ccr2_on	0	2.92	No	Yes	No	No	5	4
273	1x28	2x66	ccr2_on	0	11.19	No	No	No	No	5	4
274	1x31	7x35	ccr2_on	0	4.93	No	No	No	No	3	4
275	1x35	7x35	ccr2_on	0	7.99	Yes	No	No	No	6	4
276	1x38	7x39	ccr2_on	0	10.32	No	No	No	No	5	5
277	1x39	Lig	ccr2_on	0	4.11	Yes	Yes	Yes	Yes	7	0
278	1x43	2x57	ccr2_on	0	6.09	No	No	No	No	7	7
279	1x52	1x56	ccr2_on	0	4.28	No	No	No	No	6	7
280	1x53	1x57	ccr2_on	0	2.98	No	No	No	Yes	9	7
281	1x56	8x50	ccr2_on	0	8.79	No	No	No	No	7	8
282	I1x49	I1x50	ccr2_on	0	4.23	No	No	No	No	6	6
283	2x37	8x49	ccr2_on	0	3.23	No	No	No	No	7	6
284	2x38	3x49	ccr2_on	0	9.5	Yes	Yes	No	No	6	8
285	2x38	I2x57	ccr2_on	0	13.36	Yes	Yes	No	Yes	6	7
286	2x39	3x49	ccr2_on	0	2.89	No	No	No	No	7	8
287	2x42	3x42	ccr2_on	0	4.13	Yes	Yes	Yes	Yes	7	7
288	2x44	2x48	ccr2_on	0	4.28	Yes	Yes	No	No	6	5
289	2x46	2x50	ccr2_on	0	4.07	No	No	No	No	9	9
290	2x49	3x38	ccr2_on	0	3.71	No	No	No	No	8	7
291	2x50	7x46	ccr2_on	0	7.78	No	No	No	No	9	8
292	2x53	3x35	ccr2_on	0	3.01	No	Yes	No	No	6	8
293	2x56	2x59	ccr2_on	0	2.95	No	Yes	No	No	7	6
294	2x57	7x42	ccr2_on	0	2.83	No	No	Yes	Yes	7	7
295	E1x50	E1x51	ccr2_on	0	7.36	Yes	Yes	No	No	8	3
296	3x28	E1x50	ccr2_on	0	3.01	Yes	Yes	Yes	Yes	6	8
297	3x26	4x65	ccr2_on	0	3	No	No	No	No	7	5
298	3x33	5x43	ccr2_on	0	4.51	Yes	No	No	Yes	5	5
299	3x36	3x40	ccr2_on	0	6.04	Yes	Yes	No	No	7	8
300	3x37	3x41	ccr2_on	0	3.22	Yes	Yes	Yes	No	7	5
301	3x37	5x43	ccr2_on	0	3.21	Yes	Yes	No	Yes	7	5
302	3x40	5x461	ccr2_on	0	3.53	No	No	No	No	8	6
303	3x42	3x45	ccr2_on	0	3.65	Yes	Yes	No	Yes	7	6
304	3x43	7x49	ccr2_on	0	4.25	No	No	No	No	8	9
305	3x43	7x53	ccr2_on	0	8.46	No	No	No	Yes	8	9
306	3x44	5x49	ccr2_on	0	2.85	No	Yes	No	No	8	6
307	3x45	4x45	ccr2_on	0	2.95	No	Yes	No	No	6	5
308	3x46	7x53	ccr2_on	0	3.52	No	No	No	Yes	9	9
309	3x47	5x53	ccr2_on	0	3.04	No	Yes	No	Yes	9	6
310	3x47	5x54	ccr2_on	0	4.52	No	Yes	No	No	9	8
311	3x48	5x53	ccr2_on	0	2.94	No	No	No	Yes	6	6
312	3x49	I2x57	ccr2_on	0	11.91	No	No	No	Yes	8	7
313	3x50	7x53	ccr2_on	0	7.2	Yes	No	No	Yes	9	9
314	3x54	5x64	ccr2_on	0	3.04	No	No	No	No	8	5
315	I2x52	I2x56	ccr2_on	0	4.16	No	No	No	No	4	3
316	4x38	4x40	ccr2_on	0	3.14	No	No	No	No	7	4
317	4x59	4x63	ccr2_on	0	3.07	No	No	No	No	5	5
318	4x65	Lig	ccr2_on	0	2.83	No	No	Yes	Yes	5	0
319	E2	Lig	ccr2_on	0	12.57	Yes	Yes	Yes	Yes	3	0
320	E2x50	Lig	ccr2_on	0	6.1	No	No	Yes	Yes	9	0
321	E2x51	Lig	ccr2_on	0	6.63	No	No	Yes	Yes	4	0
322	E2x52	Lig	ccr2_on	0	14.56	No	No	Yes	Yes	4	0
323	5x36	Lig	ccr2_on	0	7.45	No	No	Yes	Yes	3	0
324	5x38	5x42	ccr2_on	0	3.73	No	No	No	No	4	4
325	5x39	5x43	ccr2_on	0	5.64	No	No	No	Yes	5	5
326	5x44	6x52	ccr2_on	0	5.45	No	No	No	No	5	8
327	5x49	5x53	ccr2_on	0	2.85	No	No	No	Yes	6	6
328	5x50	6x44	ccr2_on	0	8.34	Yes	Yes	Yes	Yes	8	9
329	5x51	6x44	ccr2_on	0	4.69	No	No	Yes	Yes	6	9
330	5x54	5x58	ccr2_on	0	3.59	No	No	No	Yes	8	8
331	5x54	6x44	ccr2_on	0	5.99	No	No	Yes	Yes	8	9
332	5x58	5x61	ccr2_on	0	3.63	No	Yes	Yes	No	8	8
333	5x58	6x40	ccr2_on	0	3.63	No	Yes	Yes	No	8	8
334	5x58	6x41	ccr2_on	0	7.18	No	Yes	No	No	8	8
335	5x62	6x34	ccr2_on	0	4.47	No	No	No	No	4	6
336	5x62	6x37	ccr2_on	0	5.71	No	No	No	No	4	7
337	6x29	I3	ccr2_on	0	8.39	No	No	No	Yes	4	0
338	6x31	I3	ccr2_on	0	9.85	No	No	No	Yes	4	0
339	6x31	6x35	ccr2_on	0	3.39	No	No	No	No	4	5
340	6x32	7x56	ccr2_on	0	3.92	No	No	No	No	6	6
341	6x32	8x51	ccr2_on	0	3.2	No	No	No	No	6	8
342	6x36	6x40	ccr2_on	0	3.07	No	No	Yes	No	8	8
343	6x36	7x56	ccr2_on	0	3.21	No	No	No	No	8	6
344	6x38	6x41	ccr2_on	0	3.73	No	No	No	No	4	8
345	6x43	6x47	ccr2_on	0	3.93	No	No	No	Yes	6	8
346	6x56	6x60	ccr2_on	0	7.31	No	No	Yes	No	6	4
347	6x57	7x30	ccr2_on	0	5.54	No	No	No	No	4	4
348	6x58	6x61	ccr2_on	0	3.96	No	No	No	Yes	4	4
349	6x60	6x64	ccr2_on	0	5.36	Yes	No	No	Yes	4	1
350	6x61	E3	ccr2_on	0	2.89	No	Yes	No	Yes	4	0
351	6x61	Lig	ccr2_on	0	8.57	No	Yes	Yes	Yes	4	0
352	6x63	6x64	ccr2_on	0	5.36	No	No	No	Yes	1	1
353	E3	Lig	ccr2_on	0	8.9	No	Yes	Yes	Yes	0	0
354	7x26	E3	ccr2_on	0	5.96	No	No	No	Yes	1	0
355	7x27	Lig	ccr2_on	0	12.48	No	No	Yes	Yes	2	0
356	7x31	Lig	ccr2_on	0	4.63	No	No	Yes	Yes	4	0
357	7x34	Lig	ccr2_on	0	4.34	No	No	Yes	Yes	4	0
358	7x38	7x42	ccr2_on	0	6.77	No	Yes	Yes	Yes	5	7
359	7x45	7x49	ccr2_on	0	10.2	No	Yes	No	No	9	9
360	7x48	7x52	ccr2_on	0	2.94	No	No	No	No	6	8
361	7x49	7x53	ccr2_on	0	4.65	No	No	No	Yes	9	9
362	7x54	8x50	ccr2_on	0	8.32	No	No	No	No	7	8
363	7x55	8x50	ccr2_on	0	8.57	No	No	No	No	7	8
364	Lig	Lig	ccr2_on	0	348.47	Yes	Yes	Yes	Yes	0	0
365	2x44	I1x49	ccr2_on	0	2.82	Yes	Yes	No	No	6	6
366	3x53	I2x57	ccr2_on	0	2.77	No	No	No	Yes	8	7
367	I2x53	I2x57	ccr2_on	0	2.77	No	No	No	Yes	5	7
368	5x47	5x51	ccr2_on	0	2.77	No	No	No	No	8	6
369	1x50	2x51	ccr2_on	0	2.75	No	Yes	No	No	9	7
370	6x47	7x43	ccr2_on	0	2.59	No	Yes	No	No	8	5
371	7x25	7x29	ccr2_on	0	2.55	No	No	No	No	0	3
372	2x46	3x42	ccr2_on	0	2.44	No	No	Yes	Yes	9	7
373	3x52	I2x52	ccr2_on	0	2.44	No	No	No	No	5	4
374	5x66	6x30	ccr2_on	0	2.43	No	No	No	No	4	5
375	2x52	4x50	ccr2_on	0	2.28	No	No	Yes	Yes	7	9
376	3x38	4x53	ccr2_on	0	1.95	No	No	No	No	7	8
377	1x36	2x61	ccr2_on	0	1.87	No	No	No	No	5	7
378	3x29	3x30	ccr2_on	0	1.82	No	No	No	No	6	6
379	3x21	3x24	ccr2_on	0	1.75	No	No	No	No	7	5
380	1x46	2x54	ccr2_on	0	1.71	No	No	No	No	8	6
381	2x38	4x42	ccr2_on	0	1.71	Yes	Yes	No	No	6	7
382	1x53	7x54	ccr2_on	0	1.7	No	No	No	No	9	7
383	1x54	2x47	ccr2_on	0	1.7	No	No	No	No	8	9
384	2x37	I1x51	ccr2_on	0	1.62	No	No	No	No	7	6
385	5x55	5x59	ccr2_on	0	1.62	No	No	No	No	4	4
386	1x28	Lig	ccr2_on	0	1.61	No	No	Yes	Yes	5	0
387	4x39	4x43	ccr2_on	0	1.6	No	No	No	No	3	4
388	4x40	4x44	ccr2_on	0	1.59	No	No	No	No	4	3
389	6x39	6x43	ccr2_on	0	1.59	No	No	No	No	5	6
390	5x65	6x33	ccr2_on	0	1.58	No	No	No	No	8	7
391	5x68	I3	ccr2_on	0	1.57	No	No	No	Yes	0	0
392	7x39	7x43	ccr2_on	0	1.57	No	No	No	No	5	5
393	1x60	2x40	ccr2_on	0	1.56	Yes	No	Yes	No	5	8
394	1x54	1x58	ccr2_on	0	1.54	No	No	No	No	8	3
395	2x41	4x39	ccr2_on	0	1.54	No	No	No	No	7	3
396	4x48	4x52	ccr2_on	0	1.54	No	No	No	No	4	4
397	2x55	2x56	ccr2_on	0	1.52	No	No	No	Yes	4	7
398	6x64	6x65	ccr2_on	0	1.51	No	Yes	No	No	1	0
399	5x33	5x34	ccr2_on	0	1.5	No	No	No	No	3	2
400	4x39	I1x50	ccr2_on	0	1.49	No	No	No	No	3	6
401	5x37	6x59	ccr2_on	0	1.46	No	No	No	No	3	5
402	4x48	4x51	ccr2_on	0	1.43	No	No	No	No	4	4
403	3x27	3x31	ccr2_on	0	1.38	No	No	No	No	4	4
404	1x29	1x30	ccr2_on	0	1.37	No	No	No	No	4	4
405	1x30	7x32	ccr2_on	0	1.37	No	No	No	No	4	1
406	3x52	I2x57	ccr2_on	0	1.21	No	No	No	Yes	5	7
407	6x30	I3	ccr2_on	0	1.16	No	No	No	Yes	5	0

Orange: nodes, hubs and links specific of ccr2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccr2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	ccr2_off Avg Int. Strength	ccr2_on Avg Int. Strength	ccr2_off Num Of Links	ccr2_on Num Of Links	ConSurf
1	1x35	ccr2_off	8.132	12.2	5	2	6
2	1x47	ccr2_off	4.3925	3.22	4	1	6
3	1x60	ccr2_off	3.9025	1.59	4	2	5
4	2x40	ccr2_off	4.56	4.47	4	3	8
5	2x60	ccr2_off	8.105	14.68	4	2	6
6	3x32	ccr2_off	7.01	9.24333	5	3	6
7	3x33	ccr2_off	9.742	3.65	5	2	5
8	3x41	ccr2_off	3.865	3.575	4	2	5
9	3x50	ccr2_off	4.6075	7.2	4	1	9
10	3x55	ccr2_off	5.288	8.05	5	3	7
11	4x61	ccr2_off	10.5275	3.01	4	1	4
12	4x64	ccr2_off	11.58	6.29	4	3	4
13	5x40	ccr2_off	6.3825	9.345	4	2	5
14	5x61	ccr2_off	2.9575	4.61333	4	3	8
15	6x40	ccr2_off	7.2625	3.21333	4	3	8
16	6x45	ccr2_off	4.73	16.86	4	1	5
17	6x51	ccr2_off	7.526	10.28	5	3	6
18	6x60	ccr2_off	5.66	6.335	4	2	4
19	1x39	Shared	8.864	7.8925	5	4	7
20	2x38	Shared	4.5	8.195	4	4	6
21	2x42	Shared	5.935	7.3025	4	4	7
22	2x44	Shared	4.5975	3.5575	4	4	6
23	E1x50	Shared	7.54143	5.70333	7	6	8
24	3x28	Shared	8.0425	6.6425	4	4	6
25	3x36	Shared	12.535	8.075	4	4	7
26	3x37	Shared	6.685	4.124	4	5	7
27	3x42	Shared	11.8725	7.02286	4	7	7
28	4x50	Shared	7.4125	5.53	4	5	9
29	E2	Shared	12.7364	16.4133	11	9	3
30	5x50	Shared	4.3875	5.6125	4	4	8
31	6x44	Shared	9.6	7.4	5	5	9
32	6x48	Shared	10.678	10.9675	5	4	9
33	6x49	Shared	3.7125	7.325	4	4	5
34	7x42	Shared	6.302	5.4275	5	4	7
35	Lig	Shared	8.55909	41.4081	11	21	0
36	NT	ccr2_on	0	11.0983	0	6	0
37	1x27	ccr2_on	4.33	3.335	3	4	5
38	1x50	ccr2_on	8.31333	6.4425	3	4	9
39	1x57	ccr2_on	4.12333	3.8375	3	4	7
40	2x53	ccr2_on	6.61667	5.8275	3	4	6
41	2x56	ccr2_on	6.06333	3.718	3	5	7
42	3x44	ccr2_on	3.65333	4.245	3	4	8
43	3x45	ccr2_on	5.725	5.47	2	4	6
44	3x47	ccr2_on	7.93	3.6725	2	4	9
45	I2x57	ccr2_on	1.86	6.404	2	5	7
46	5x43	ccr2_on	9.83667	6.685	3	4	5
47	5x53	ccr2_on	2.94	3.3125	1	4	6
48	5x58	ccr2_on	11.6733	4.83833	3	6	8
49	I3	ccr2_on	0	5.2425	0	4	0
50	6x47	ccr2_on	6.25667	5.72	3	4	8
51	6x61	ccr2_on	4.915	4.5625	2	4	4
52	6x64	ccr2_on	3.31667	3.6675	3	4	1
53	E3	ccr2_on	0	6.2575	0	4	0
54	7x38	ccr2_on	10.3533	7.4725	3	4	5
55	7x45	ccr2_on	8.05333	10.6675	3	4	9
56	7x53	ccr2_on	5.97	5.9575	3	4	9

Orange: nodes, hubs and links specific of ccr2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccr2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ccr2_off Recurrence	ccr2_on Recurrence	ccr2_off Hub1?	ccr2_on Hub1?	ccr2_off Hub2?	ccr2_on Hub2?	ConSurf1	ConSurf2
1	1x35	Lig	ccr2_off	24.0291	0	Yes	No	Yes	Yes	6	0
2	1x35	1x39	ccr2_off	12.096	2.69736	Yes	No	Yes	Yes	6	7
3	7x42	Lig	ccr2_off	14.3385	0	Yes	Yes	Yes	Yes	7	0
4	1x35	2x64	ccr2_off	10.0476	0	Yes	No	No	No	6	5
5	1x39	2x57	ccr2_off	28.4578	0	Yes	Yes	No	No	7	7
6	1x42	2x57	ccr2_off	24.9436	4.40668	No	No	No	No	7	7
7	1x42	7x47	ccr2_off	14.326	0	No	No	No	No	7	8
8	1x46	7x47	ccr2_off	10.7617	2.48987	No	No	No	No	8	8
9	2x54	7x46	ccr2_off	24.1669	0	No	No	No	No	6	8
10	1x47	2x54	ccr2_off	11.8329	0	Yes	No	No	No	6	6
11	1x50	2x54	ccr2_off	13.092	9.87057	No	Yes	No	No	9	6
12	3x33	Lig	ccr2_off	41.2804	0	Yes	No	Yes	Yes	5	0
13	3x33	3x37	ccr2_off	75.094	0	Yes	No	Yes	Yes	5	7
14	3x37	5x46	ccr2_off	100	7.28189	Yes	Yes	No	No	7	4
15	3x41	5x46	ccr2_off	98.1709	0	Yes	No	No	No	5	4
16	3x41	4x49	ccr2_off	95.446	0	Yes	No	No	No	5	7
17	3x45	4x49	ccr2_off	84.4087	0.128446	No	Yes	No	No	6	7
18	2x42	3x45	ccr2_off	83.3375	0.207489	Yes	Yes	No	Yes	7	6
19	2x42	3x46	ccr2_off	73.0393	0	Yes	Yes	No	No	7	9
20	2x43	3x46	ccr2_off	45.4899	0	No	No	No	No	8	9
21	1x57	2x43	ccr2_off	44.0366	2.46023	No	Yes	No	No	7	8
22	2x40	I1x48	ccr2_off	22.7449	0	Yes	No	No	No	8	6
23	3x42	4x49	ccr2_off	17.5332	2.40095	Yes	Yes	No	No	7	7
24	3x36	6x44	ccr2_off	31.0887	0	Yes	Yes	Yes	Yes	7	9
25	6x44	6x45	ccr2_off	24.4926	0	Yes	Yes	Yes	No	9	5
26	6x41	6x45	ccr2_off	19.2496	0	No	No	Yes	No	8	5
27	3x43	6x41	ccr2_off	15.8168	0	No	No	No	No	8	8
28	6x48	6x51	ccr2_off	26.7226	0	Yes	Yes	Yes	No	9	6
29	2x60	E1x50	ccr2_off	18.7422	0	Yes	No	Yes	Yes	6	8
30	E1x50	E1x52	ccr2_off	10.9121	0	Yes	Yes	No	No	8	7
31	3x33	4x61	ccr2_off	28.3576	0	Yes	No	Yes	No	5	4
32	4x61	E2	ccr2_off	23.766	2.45035	Yes	No	Yes	Yes	4	3
33	3x40	6x44	ccr2_off	18.3099	0	No	No	Yes	Yes	8	9
34	3x40	5x50	ccr2_off	16.3054	0	No	No	Yes	Yes	8	8
35	3x43	6x40	ccr2_off	12.5094	0	No	No	Yes	No	8	8
36	3x44	5x50	ccr2_off	10.2167	9.95949	No	Yes	Yes	Yes	8	8
37	3x46	6x37	ccr2_off	33.3312	0	No	No	No	No	9	7
38	5x58	6x37	ccr2_off	31.7402	7.25225	No	Yes	No	No	8	7
39	3x47	5x58	ccr2_off	25.5763	2.30214	No	Yes	No	Yes	9	8
40	3x55	5x61	ccr2_off	10.4109	0	Yes	No	Yes	No	7	8
41	5x43	6x51	ccr2_off	12.6973	0	No	Yes	Yes	No	5	6
42	6x51	7x37	ccr2_off	26.4032	3.15186	Yes	No	No	No	6	7
43	6x29	I1x48	ccr2_off	13.236	0	No	No	No	No	4	6
44	6x54	7x37	ccr2_off	22.5319	0	No	No	No	No	5	7
45	6x54	7x34	ccr2_off	18.1158	4.96986	No	No	No	No	5	4
46	6x58	7x34	ccr2_off	15.8983	0	No	No	No	No	4	4
47	6x58	7x30	ccr2_off	13.662	0	No	No	No	No	4	4
48	2x37	2x40	ccr2_off	10.1917	7.20285	No	No	Yes	No	7	8
49	3x32	7x42	ccr2_off	10.9935	0	Yes	No	Yes	Yes	6	7
50	3x32	3x33	ccr2_off	20.8281	0	Yes	No	Yes	No	6	5
51	3x32	7x38	ccr2_off	10.0413	6.18516	Yes	No	No	Yes	6	5
52	1x39	7x42	Shared	25.9208	13.803	Yes	Yes	Yes	Yes	7	7
53	2x53	3x32	Shared	17.1511	52.1984	No	Yes	Yes	No	6	6
54	2x53	7x46	Shared	25.5638	69.8449	No	Yes	No	No	6	8
55	1x57	2x40	Shared	35.1917	14.376	No	Yes	Yes	No	7	8
56	3x42	4x50	Shared	12.3591	66.6238	Yes	Yes	Yes	Yes	7	9
57	3x36	3x37	Shared	58.6382	17.3303	Yes	Yes	Yes	Yes	7	7
58	7x38	Lig	Shared	21.68	23.0807	No	Yes	Yes	Yes	5	0
59	6x51	7x38	Shared	30.5437	24.7308	Yes	No	No	Yes	6	5
60	6x44	6x48	Shared	12.1398	57.6228	Yes	Yes	Yes	Yes	9	9
61	2x60	Lig	Shared	20.0138	16.362	Yes	No	Yes	Yes	6	0
62	E1x50	E2	Shared	14.0692	20.4426	Yes	Yes	Yes	Yes	8	3
63	3x47	5x57	Shared	23.9414	19.4348	No	Yes	No	No	9	7
64	3x51	5x57	Shared	22.2939	17.0734	No	No	No	No	8	7
65	3x51	3x55	Shared	18.8925	14.6922	No	No	Yes	No	8	7
66	6x51	6x55	Shared	17.6773	18.6642	Yes	No	No	No	6	6
67	5x40	6x55	Shared	16.1927	15.6012	Yes	No	No	No	5	6
68	3x36	5x43	Shared	12.9291	71.732	Yes	Yes	No	Yes	7	5
69	3x36	6x48	Shared	14.6642	81.5828	Yes	Yes	Yes	Yes	7	9
70	1x27	NT	ccr2_on	0	14.3958	No	Yes	No	Yes	5	0
71	Lig	NT	ccr2_on	0	16.2138	Yes	Yes	No	Yes	0	0
72	1x27	7x31	ccr2_on	0	14.1587	No	Yes	No	No	5	4
73	7x31	Lig	ccr2_on	0	16.2237	No	No	Yes	Yes	4	0
74	1x30	7x32	ccr2_on	0	14.3662	No	No	No	No	4	1
75	1x27	7x32	ccr2_on	1.92308	19.1187	No	Yes	No	No	5	1
76	1x39	Lig	ccr2_on	0	18.3678	Yes	Yes	Yes	Yes	7	0
77	6x47	7x45	ccr2_on	6.62741	15.9668	No	Yes	No	Yes	8	9
78	6x48	7x45	ccr2_on	5.3558	24.1873	Yes	Yes	No	Yes	9	9
79	5x39	5x43	ccr2_on	0	82.5314	No	No	No	Yes	5	5
80	5x39	E2	ccr2_on	0.269356	82.6302	No	No	Yes	Yes	5	3
81	E2	Lig	ccr2_on	0	80.5948	Yes	Yes	Yes	Yes	3	0
82	7x38	7x42	ccr2_on	0	15.9372	No	Yes	Yes	Yes	5	7
83	2x57	7x42	ccr2_on	0	21.8753	No	No	Yes	Yes	7	7
84	1x43	2x57	ccr2_on	0	13.1805	No	No	No	No	7	7
85	1x50	2x50	ccr2_on	8.23102	17.0734	No	Yes	No	No	9	9
86	2x50	7x46	ccr2_on	0	69.9239	No	No	No	No	9	8
87	3x32	Lig	ccr2_on	2.95665	46.774	Yes	No	Yes	Yes	6	0
88	7x54	8x50	ccr2_on	0	12.1431	No	No	No	No	7	8
89	1x53	7x54	ccr2_on	0	14.5144	No	No	No	No	9	7
90	1x53	1x57	ccr2_on	0	16.7375	No	No	No	Yes	9	7
91	1x57	2x44	ccr2_on	8.89501	34.542	No	Yes	Yes	Yes	7	6
92	2x44	2x48	ccr2_on	0	53.6805	Yes	Yes	No	No	6	5
93	2x48	4x50	ccr2_on	5.40591	55.6763	No	No	Yes	Yes	5	9
94	2x46	3x42	ccr2_on	0	100	No	No	Yes	Yes	9	7
95	2x46	2x50	ccr2_on	0	72.4533	No	No	No	No	9	9
96	2x44	I1x49	ccr2_on	0	12.1431	Yes	Yes	No	No	6	6
97	2x38	2x42	ccr2_on	7.11601	23.4562	Yes	Yes	Yes	Yes	6	7
98	2x42	3x42	ccr2_on	0	29.8785	Yes	Yes	Yes	Yes	7	7
99	2x38	I2x57	ccr2_on	0	14.2772	Yes	Yes	No	Yes	6	7
100	2x46	3x43	ccr2_on	2.10474	61.2785	No	No	No	No	9	8
101	2x56	2x60	ccr2_on	8.83864	14.3266	No	Yes	Yes	No	7	6
102	3x28	E1x50	ccr2_on	0	15.9569	Yes	Yes	Yes	Yes	6	8
103	E2x50	Lig	ccr2_on	0	11.0068	No	No	Yes	Yes	9	0
104	3x37	5x43	ccr2_on	0	12.9631	Yes	Yes	No	Yes	7	5
105	3x36	3x40	ccr2_on	0	10.0978	Yes	Yes	No	No	7	8
106	3x37	3x41	ccr2_on	0	19.0396	Yes	Yes	Yes	No	7	5
107	3x41	4x52	ccr2_on	1.80406	16.7276	Yes	No	No	No	5	4
108	3x43	7x49	ccr2_on	0	56.7928	No	No	No	No	8	9
109	7x45	7x49	ccr2_on	0	59.8557	No	Yes	No	No	9	9
110	5x50	6x44	ccr2_on	0	14.4749	Yes	Yes	Yes	Yes	8	9
111	3x47	5x54	ccr2_on	0	21.4208	No	Yes	No	No	9	8
112	5x54	6x44	ccr2_on	0	61.5255	No	No	Yes	Yes	8	9
113	5x54	5x58	ccr2_on	0	38.3757	No	No	No	Yes	8	8
114	5x58	5x61	ccr2_on	0	11.9949	No	Yes	Yes	No	8	8
115	4x48	4x52	ccr2_on	0	14.3958	No	No	No	No	4	4
116	4x64	E2	ccr2_on	9.51516	14.4551	Yes	No	Yes	Yes	4	3
117	5x40	6x59	ccr2_on	2.71235	12.5185	Yes	No	No	No	5	5
118	5x44	6x52	ccr2_on	0	19.1187	No	No	No	No	5	8
119	5x47	6x52	ccr2_on	1.3781	21.4208	No	No	No	No	8	8
120	5x47	5x51	ccr2_on	0	32.6351	No	No	No	No	8	6
121	5x51	6x44	ccr2_on	0	34.8187	No	No	Yes	Yes	6	9
122	5x44	6x56	ccr2_on	2.15485	16.7968	No	No	No	No	5	6
123	5x58	6x40	ccr2_on	0	16.4213	No	Yes	Yes	No	8	8
124	6x56	6x60	ccr2_on	0	14.4551	No	No	Yes	No	6	4
125	6x60	6x64	ccr2_on	0	12.0937	Yes	No	No	Yes	4	1
126	2x53	7x42	ccr2_on	9.82836	17.6564	No	Yes	Yes	Yes	6	7
127	6x44	7x45	ccr2_on	3.45152	41.982	Yes	Yes	No	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x27	7x32	Shared	8.6	1.43	0	1	2	2
1x31	Lig	ccr2_off	6.19	0	0	0	1	0
1x34	1x35	ccr2_off	4.15	0	0	0	2	1
1x35	1x39	Shared	16.41	16.41	1	0	1	1
1x35	7x39	ccr2_off	4.42	0	1	0	1	2
1x35	Lig	ccr2_off	12.53	0	1	0	1	0
1x39	2x57	ccr2_off	7.03	0	1	1	1	2
1x39	7x39	ccr2_off	6.24	0	1	1	1	2
1x39	7x42	Shared	11.97	8.38	1	1	1	1
2x53	3x32	Shared	9.28	12.38	1	0	2	1
2x53	7x42	Shared	4.98	3.73	1	0	2	1
2x56	2x60	Shared	7.28	7.28	0	1	2	1
2x60	E1x50	ccr2_off	4.69	0	1	1	1	2
2x60	7x42	ccr2_off	4.65	0	1	1	1	1
2x60	Lig	Shared	15.8	22.08	1	1	1	0
3x25	E1x50	Shared	3.92	3.92	1	1	2	2
E1x50	E2	Shared	6.18	5.85	1	1	2	1
E1x50	E2x50	Shared	16.98	9.14	1	1	2	1
3x22	E2	Shared	7.52	3.15	0	0	2	1
3x25	E2x50	Shared	7.28	7.28	1	1	2	1
3x26	E2	ccr2_off	7.18	0	0	0	2	1
3x29	4x65	Shared	10.99	14.13	0	1	1	1
3x29	Lig	Shared	7.11	12.76	0	1	1	0
3x32	3x33	ccr2_off	8.71	0	1	1	1	1
3x32	7x38	Shared	4.49	5.61	1	1	1	1
3x32	7x42	ccr2_off	4.79	0	1	1	1	1
3x32	Lig	Shared	7.78	9.74	1	1	1	0
3x33	3x37	ccr2_off	5.66	0	1	0	1	2
3x33	4x57	Shared	4.18	2.79	1	0	1	2
3x33	4x61	ccr2_off	25.51	0	1	0	1	2
3x33	Lig	ccr2_off	4.65	0	1	0	1	0
4x61	E2	Shared	6.04	3.01	1	0	2	1
4x61	5x39	ccr2_off	8.93	0	1	0	2	2
4x64	E2	Shared	16.08	7.5	1	1	2	1
E2	E2	Shared	41	48.58	1	1	1	1
E2x51	E2x52	Shared	4.06	4.06	0	1	1	1
5x36	E2	Shared	4.83	6.04	1	1	1	1
5x39	E2	Shared	4.53	12.44	1	1	2	1
5x36	6x59	ccr2_off	4.39	0	1	1	1	2
5x43	6x51	ccr2_off	7.2	0	0	1	2	2
6x51	7x38	Shared	8.98	11.22	0	0	2	1
6x54	7x34	Shared	4.76	3.17	0	0	2	1
6x58	7x30	ccr2_off	4.12	0	0	0	2	2
6x58	7x34	ccr2_off	4.39	0	0	0	2	1
6x61	7x27	Shared	8.5	2.83	0	1	1	1
7x35	Lig	Shared	11.24	3.03	0	1	1	0
7x38	Lig	Shared	17.59	6.29	1	1	1	0
7x42	Lig	ccr2_off	5.12	0	1	0	1	0
1x30	Lig	ccr2_off	3.44	0	0	0	1	0
1x35	2x64	ccr2_off	3.15	0	1	0	1	2
E2	E2x52	ccr2_off	2.89	0	1	1	1	1
1x27	7x35	ccr2_off	2.87	0	0	1	2	1
E1x49	E2	ccr2_off	2.85	0	0	0	2	1
7x36	Lig	ccr2_off	2.7	0	0	0	1	0
1x39	2x61	Shared	2.67	2.67	1	1	1	2
1x27	1x28	ccr2_off	1.52	0	0	1	2	1
6x61	7x30	ccr2_off	1.33	0	0	1	1	2
7x31	7x35	ccr2_off	1.31	0	0	1	1	1
Lig	NT	ccr2_on	0	23.95	1	1	0	1
NT	NT	ccr2_on	0	12.28	0	1	1	1
E3	NT	ccr2_on	0	7.28	0	1	1	1
1x27	NT	ccr2_on	0	5.76	0	1	2	1
7x31	NT	ccr2_on	0	5.04	0	1	1	1
1x27	7x31	ccr2_on	0	2.92	0	1	2	1
1x28	2x66	ccr2_on	0	11.19	0	1	1	2
1x31	7x35	ccr2_on	0	4.93	0	0	1	1
1x35	7x35	ccr2_on	0	7.99	1	0	1	1
1x39	Lig	ccr2_on	0	4.11	1	1	1	0
2x57	7x42	ccr2_on	0	2.83	0	0	2	1
3x26	4x65	ccr2_on	0	3	0	0	2	1
3x33	5x43	ccr2_on	0	4.51	1	0	1	2
3x37	5x43	ccr2_on	0	3.21	0	1	2	2
4x65	Lig	ccr2_on	0	2.83	0	1	1	0
E2	Lig	ccr2_on	0	12.57	1	1	1	0
E2x50	Lig	ccr2_on	0	6.1	1	1	1	0
E2x51	Lig	ccr2_on	0	6.63	0	1	1	0
E2x52	Lig	ccr2_on	0	14.56	1	1	1	0
5x36	Lig	ccr2_on	0	7.45	1	1	1	0
5x39	5x43	ccr2_on	0	5.64	1	1	2	2
6x58	6x61	ccr2_on	0	3.96	0	0	2	1
6x61	E3	ccr2_on	0	2.89	0	1	1	1
6x61	Lig	ccr2_on	0	8.57	0	1	1	0
E3	Lig	ccr2_on	0	8.9	0	1	1	0
7x26	E3	ccr2_on	0	5.96	0	0	2	1
7x27	Lig	ccr2_on	0	12.48	0	1	1	0
7x31	Lig	ccr2_on	0	4.63	0	1	1	0
7x34	Lig	ccr2_on	0	4.34	0	1	1	0
7x38	7x42	ccr2_on	0	6.77	1	1	1	1
3x29	3x30	ccr2_on	0	1.82	0	1	1	2
1x28	Lig	ccr2_on	0	1.61	0	1	1	0
1x29	1x30	ccr2_on	0	1.37	0	0	2	1
1x30	7x32	ccr2_on	0	1.37	0	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	ccr2_off	6GPS-CCR2-MK0812
	ccr2_on	7XA3-CCR2-CCL2-Gi1/β1/γ2

Network Difference
Value	ccr2_off	ccr2_on
I_min	3.89	2.83
Number of Linked Nodes	246	240
Number of Specific Nodes	23 (9.35%)	17 (7.08%)
Number of Shared Nodes	223 (90.65%)	223 (92.92%)
Number of Links	265	268
Number of Specific Links	139 (52.45%)	142 (52.99%)
Number of Shared Links	126 (47.55%)	126 (47.01%)
Number of Hubs	35	38
Number of Specific Hubs	18 (51.43%)	21 (55.26%)
Number of Shared Hubs	17 (48.57%)	17 (44.74%)
Average % Shared Neighbours (Jaccard)	33.01
Average % Shared Neighbours (Otsuka)	41.75
Average % Shared Neighbours (Overlap Coefficient)	50.97
Average % Shared Cliques (k3-6)	78.47
Graphlets Similarity	0.537865

Paths Difference
Value	ccr2_off	ccr2_on
Number Of Nodes in MetaPath	63	71
Specific Nodes in MetaPath	27 (42.86%)	35 (49.30%)
Shared Nodes in MetaPath	223 (90.65%)	223 (90.65%)
Number Of Links MetaPath	69	76
Specific Links in MetaPath	51 (73.91%)	58 (76.32%)
Shared Links in MetaPath	126 (47.55%)	126 (47.55%)
Number of Shortest Paths	34912	30463
Length Of Smallest Path	3	3
Average Path Length	12.4178	11.0867
Length of Longest Path	27	24
Minimum Path Strength	1.355	1.365
Average Path Strength	6.84733	6.56464
Maximum Path Strength	17.11	17.77
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.914569	0.941627
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.34783	6.25
Average % Of Corr. Nodes	49.5827	61.7051
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	44.1211	46.2707
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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