Orange: nodes, hubs and links specific of ccr2_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccr2_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner ccr2_on_gp Avg Int. Strength ccr2_off Avg Int. Strength ccr2_on_gp Num Of Links ccr2_off Num Of Links ConSurf
1NT ccr2_on_gp11.09830604
21x27 ccr2_on_gp3.3354.33435
31x50 ccr2_on_gp6.44258.31333439
41x53 ccr2_on_gp2.03754.22429
51x57 ccr2_on_gp3.83754.12333437
62x37 ccr2_on_gp5.10253.245427
72x46 ccr2_on_gp3.28255.71419
82x49 ccr2_on_gp3.59754.325428
92x53 ccr2_on_gp5.0746.61667536
102x56 ccr2_on_gp3.7186.06333537
113x29 ccr2_on_gp7.86259.05426
123x44 ccr2_on_gp4.2453.65333438
133x45 ccr2_on_gp5.475.725426
143x47 ccr2_on_gp3.67257.93429
153x49 ccr2_on_gp6.653.57418
16I2x57 ccr2_on_gp6.4041.86527
174x65 ccr2_on_gp5.44510.99415
185x43 ccr2_on_gp6.6859.83667435
195x53 ccr2_on_gp3.31252.94416
205x58 ccr2_on_gp4.8383311.6733638
21I3 ccr2_on_gp6.726670602
226x47 ccr2_on_gp5.726.25667438
236x61 ccr2_on_gp4.56254.915424
246x64 ccr2_on_gp3.4223.31667531
25E3 ccr2_on_gp6.25750404
267x38 ccr2_on_gp7.472510.3533435
277x45 ccr2_on_gp9.0888.05333539
287x53 ccr2_on_gp4.7655.97639
29G.HN.11 ccr2_on_gp2.9160502
30G.HN.43 ccr2_on_gp2.8350409
31G.HN.47 ccr2_on_gp2.8350406
32G.S1.02 ccr2_on_gp5.0340505
33G.S1.04 ccr2_on_gp4.0750407
34G.S1.06 ccr2_on_gp4.20408
35G.S1.07 ccr2_on_gp5.2050409
36G.s1h1.02 ccr2_on_gp2.4750407
37G.H1.01 ccr2_on_gp4.3550409
38G.H1.07 ccr2_on_gp4.9750409
39G.H1.08 ccr2_on_gp5.87250408
40G.S2.01 ccr2_on_gp3.50750409
41G.S2.08 ccr2_on_gp7.386670605
42G.S3.02 ccr2_on_gp6.90250404
43G.S3.03 ccr2_on_gp6.234290707
44G.S3.04 ccr2_on_gp7.160406
45G.S3.06 ccr2_on_gp6.593330605
46G.s3h2.03 ccr2_on_gp6.540409
47G.H2.03 ccr2_on_gp4.5140509
48G.H2.06 ccr2_on_gp4.7050809
49G.H2.07 ccr2_on_gp5.505710709
50G.H2.09 ccr2_on_gp6.07250408
51G.H2.10 ccr2_on_gp3.49750407
52G.h2s4.01 ccr2_on_gp6.337140709
53G.S4.02 ccr2_on_gp5.36750408
54G.S4.03 ccr2_on_gp3.1450407
55G.S4.04 ccr2_on_gp5.011430709
56G.s4h3.01 ccr2_on_gp5.50407
57G.s4h3.04 ccr2_on_gp8.4540508
58G.H3.06 ccr2_on_gp3.57250406
59G.H3.09 ccr2_on_gp4.9880509
60G.H3.13 ccr2_on_gp4.40250405
61G.H3.17 ccr2_on_gp6.820605
62G.H3.18 ccr2_on_gp7.88250409
63G.S5.03 ccr2_on_gp2.9780508
64G.S5.04 ccr2_on_gp3.92750409
65G.S5.05 ccr2_on_gp4.124290709
66G.HG.04 ccr2_on_gp5.045710709
67G.HG.08 ccr2_on_gp4.2620506
68G.HG.15 ccr2_on_gp3.643330607
69G.hgh4.01 ccr2_on_gp4.20750406
70G.hgh4.02 ccr2_on_gp6.458570707
71G.H4.03 ccr2_on_gp3.350404
72G.H4.11 ccr2_on_gp3.1560507
73G.H4.15 ccr2_on_gp3.610508
74G.h4s6.10 ccr2_on_gp2.860403
75G.h4s6.11 ccr2_on_gp4.48250407
76G.S6.02 ccr2_on_gp3.448570707
77G.S6.05 ccr2_on_gp4.020404
78G.H5.03 ccr2_on_gp5.230408
79G.H5.08 ccr2_on_gp6.620508
80G.H5.15 ccr2_on_gp3.35750407
81G.H5.20 ccr2_on_gp4.7580509
82G.H5.26 ccr2_on_gp8.0060505
83b.h2x5 ccr2_on_gp3.7350405
84b.lhb1x3 ccr2_on_gp4.950402
85b.lhb1x6 ccr2_on_gp5.35750403
86b.b1x3 ccr2_on_gp4.41750407
87b.l1x3 ccr2_on_gp7.703330609
88b.b2x1 ccr2_on_gp6.9920508
89b.b2x5 ccr2_on_gp7.5550607
90b.l2x5 ccr2_on_gp10.7850405
91b.b3x3 ccr2_on_gp4.08750408
92b.b3x4 ccr2_on_gp5.37250409
93b.b4x3 ccr2_on_gp4.62750407
94b.b4x4 ccr2_on_gp7.79250408
95b.b4x6 ccr2_on_gp8.192860709
96b.l4x1 ccr2_on_gp4.170405
97b.l4x2 ccr2_on_gp12.1550404
98b.b5x2 ccr2_on_gp5.92250407
99b.b5x3 ccr2_on_gp6.030709
100b.b5x5 ccr2_on_gp5.640405
101b.b5x7 ccr2_on_gp6.1150407
102b.l5x1 ccr2_on_gp4.87750408
103b.l5x5 ccr2_on_gp7.696250809
104b.b6x5 ccr2_on_gp4.128330606
105b.b7x1 ccr2_on_gp6.2250404
106b.b7x4 ccr2_on_gp3.5150408
107b.l7x2 ccr2_on_gp4.508570709
108b.b8x2 ccr2_on_gp4.180408
109b.b8x3 ccr2_on_gp3.3880506
110b.b8x4 ccr2_on_gp5.322860706
111b.l8x8 ccr2_on_gp5.47250404
112b.l8x10 ccr2_on_gp4.720404
113b.b9x3 ccr2_on_gp5.07250406
114b.l9x3 ccr2_on_gp7.231430709
115b.l9x5 ccr2_on_gp1.87250408
116b.l9x6 ccr2_on_gp3.46801008
117b.b10x2 ccr2_on_gp50406
118b.b10x5 ccr2_on_gp3.99250409
119b.l10x1 ccr2_on_gp4.520403
120b.b11x2 ccr2_on_gp3.7620507
121b.b11x4 ccr2_on_gp4.5840509
122b.l11x1 ccr2_on_gp2.9750409
123b.l11x2 ccr2_on_gp9.69750409
124b.b12x3 ccr2_on_gp4.2450408
125b.b12x6 ccr2_on_gp8.5450608
126b.b13x5 ccr2_on_gp4.3150404
127b.b13x7 ccr2_on_gp9.0780507
128b.l13x3 ccr2_on_gp7.806670609
129b.l13x6 ccr2_on_gp5.23750409
130b.l13x7 ccr2_on_gp5.00250409
131b.b14x3 ccr2_on_gp5.3720505
132b.b15x1 ccr2_on_gp7.501670609
133b.b15x3 ccr2_on_gp4.2050609
134b.l15x1 ccr2_on_gp5.91250407
135b.l15x2 ccr2_on_gp4.9620509
136b.b16x4 ccr2_on_gp10.50250406
137b.b16x6 ccr2_on_gp9.296670608
138b.b17x5 ccr2_on_gp8.49250407
139b.b17x7 ccr2_on_gp9.59750408
140b.l17x3 ccr2_on_gp7.20609
141b.l17x6 ccr2_on_gp6.1020509
142b.b18x3 ccr2_on_gp5.0950408
143b.b18x5 ccr2_on_gp5.60405
144b.l18x1 ccr2_on_gp5.992860706
145b.l18x3 ccr2_on_gp7.25250405
146b.b19x2 ccr2_on_gp6.6150606
147b.b19x4 ccr2_on_gp4.271670608
148b.b19x5 ccr2_on_gp2.70250405
149b.l19x1 ccr2_on_gp6.1950409
150b.l19x2 ccr2_on_gp5.61750409
151b.b20x4 ccr2_on_gp10.8140508
152b.b20x6 ccr2_on_gp6.658330606
153b.l20x2 ccr2_on_gp9.17750409
154b.b21x7 ccr2_on_gp4.682860705
155b.l21x5 ccr2_on_gp5.6820504
156b.l21x7 ccr2_on_gp3.4950405
157b.b22x5 ccr2_on_gp6.54250407
158b.l22x1 ccr2_on_gp4.6450409
159b.l22x4 ccr2_on_gp2.190409
160b.l22x5 ccr2_on_gp6.40509
161b.b23x1 ccr2_on_gp4.6950405
162b.b23x6 ccr2_on_gp6.804290707
163b.l23x1 ccr2_on_gp6.20750406
164b.b24x3 ccr2_on_gp4.2950405
165b.b24x4 ccr2_on_gp5.6960506
166b.b24x5 ccr2_on_gp4.28750405
167b.b24x6 ccr2_on_gp6.2150408
168b.b25x3 ccr2_on_gp6.2240505
169b.b25x6 ccr2_on_gp3.5250403
170b.l25x3 ccr2_on_gp10.1660509
171b.b26x3 ccr2_on_gp5.67250406
172b.l26x1 ccr2_on_gp6.32250407
173b.b27x1 ccr2_on_gp3.79750406
174b.b27x3 ccr2_on_gp4.8750408
175b.l27x1 ccr2_on_gp11.59140709
176b.l27x2 ccr2_on_gp9.60750409
177b.b28x4 ccr2_on_gp6.580406
178b.b28x6 ccr2_on_gp8.4260509
179b.b28x7 ccr2_on_gp9.290409
180g.h1x11 ccr2_on_gp2.1250409
181g.h2x11 ccr2_on_gp6.63250406
182g.ctx3 ccr2_on_gp6.6420509
183g.ctx4 ccr2_on_gp3.10407
184g.ctx6 ccr2_on_gp4.77250406
185g.ctx14 ccr2_on_gp5.220509
186g.ctx16 ccr2_on_gp5.205560908
1871x39 Shared7.89258.864457
1882x38 Shared8.1954.5446
1892x42 Shared5.641675.935647
1902x44 Shared3.55754.5975446
1912x60 Shared8.45758.105446
192E1x50 Shared5.703337.54143678
1933x28 Shared5.7148.0425546
1943x32 Shared7.47757.01456
1953x33 Shared3.0559.742455
1963x36 Shared6.87212.535547
1973x37 Shared3.876676.685647
1983x42 Shared6.47511.8725847
1994x50 Shared4.638577.4125749
200E2 Shared16.413312.73649113
2015x50 Shared5.61254.3875448
2025x61 Shared4.0652.9575448
2036x44 Shared6.579.6659
2046x48 Shared9.1610.678559
2056x49 Shared7.3253.7125445
2066x51 Shared8.19257.526456
2077x42 Shared5.42756.302457
208Lig Shared41.40818.5590921110
2091x35 ccr2_off12.28.132256
2101x47 ccr2_off3.224.3925146
2111x60 ccr2_off1.593.9025245
2122x40 ccr2_off4.474.56348
2133x41 ccr2_off3.5753.865245
2143x50 ccr2_off4.603334.6075349
2153x55 ccr2_off8.055.288357
2164x61 ccr2_off2.41510.5275244
2174x64 ccr2_off6.2911.58344
2185x40 ccr2_off9.3456.3825245
2196x40 ccr2_off3.213337.2625348
2206x45 ccr2_off16.864.73145
2216x60 ccr2_off6.3355.66244
   
Orange: nodes, hubs and links specific of ccr2_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccr2_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner ccr2_on_gp Recurrence ccr2_off Recurrence ccr2_on_gp Hub1? ccr2_off Hub1? ccr2_on_gp Hub2? ccr2_off Hub2? ConSurf1 ConSurf2
16x48 7x45 ccr2_on_gp22.59515.3558YesYesYesNo99
22x50 7x46 ccr2_on_gp16.46140NoNoNoNo98
33x32 Lig ccr2_on_gp13.02932.95665YesYesYesYes60
42x42 3x42 ccr2_on_gp16.91540YesYesYesYes77
52x46 2x50 ccr2_on_gp19.89270YesNoNoNo99
62x46 7x53 ccr2_on_gp20.12590YesNoYesNo99
77x49 7x53 ccr2_on_gp24.60230NoNoYesNo99
87x45 7x49 ccr2_on_gp24.44360YesNoNoNo99
93x37 3x41 ccr2_on_gp11.36720YesYesNoYes75
103x41 4x52 ccr2_on_gp10.55561.80406NoYesNoNo54
115x54 6x44 ccr2_on_gp23.12430NoNoYesYes89
125x54 5x58 ccr2_on_gp23.18750NoNoYesNo88
133x50 7x53 ccr2_on_gp45.62480NoYesYesNo99
143x50 G.H5.23 ccr2_on_gp30.4150NoYesNoNo94
153x50 G.H5.25 ccr2_on_gp15.48240NoYesNoNo97
165x58 5x61 ccr2_on_gp24.87450YesNoYesYes88
173x53 G.H5.23 ccr2_on_gp30.54930NoNoNoNo84
183x53 G.H5.19 ccr2_on_gp50.46590NoNoNoNo88
193x54 5x61 ccr2_on_gp13.07875.12403NoNoYesYes88
203x54 G.H5.20 ccr2_on_gp13.21150NoNoYesNo89
215x65 G.H5.20 ccr2_on_gp13.13440NoNoYesNo89
225x61 5x65 ccr2_on_gp13.06511.80406YesYesNoNo88
23G.H5.20 G.H5.25 ccr2_on_gp15.54650YesNoNoNo97
24G.H5.15 G.H5.19 ccr2_on_gp50.59860YesNoNoNo78
256x29 I3 ccr2_on_gp42.78010NoNoYesNo42
266x29 G.H5.26 ccr2_on_gp42.72750NoNoYesNo45
27G.H5.20 G.H5.26 ccr2_on_gp42.01270YesNoYesNo95
28G.S6.02 I3 ccr2_on_gp43.05160YesNoYesNo72
29G.h2s4.01 b.l5x5 ccr2_on_gp10.70780YesNoYesNo99
30G.S1.05 G.h2s4.01 ccr2_on_gp70.69350NoNoYesNo99
31G.S1.05 G.S1.07 ccr2_on_gp70.70860NoNoYesNo99
32G.S1.07 G.S4.04 ccr2_on_gp1000YesNoYesNo99
33G.S4.04 G.s1h1.01 ccr2_on_gp47.28320YesNoNoNo99
34G.s1h1.01 G.s1h1.05 ccr2_on_gp47.28540NoNoNoNo99
35G.s1h1.02 G.s1h1.05 ccr2_on_gp47.29030YesNoNoNo79
36G.s1h1.02 G.s1h1.03 ccr2_on_gp97.2580YesNoNoNo78
37G.H1.01 G.s1h1.03 ccr2_on_gp97.22860YesNoNoNo98
38G.H1.01 G.S1.06 ccr2_on_gp97.02370YesNoYesNo98
39G.S1.06 G.S4.03 ccr2_on_gp96.01760YesNoYesNo87
40G.S1.04 G.S4.03 ccr2_on_gp51.9090YesNoYesNo77
41G.S1.02 G.S1.04 ccr2_on_gp25.5570YesNoYesNo57
42G.H5.11 G.S1.02 ccr2_on_gp25.45950NoNoYesNo85
43G.H5.11 G.H5.15 ccr2_on_gp50.99710NoNoYesNo87
44b.b26x1 b.b26x2 ccr2_on_gp10.47460NoNoNoNo97
45b.b26x1 b.l27x1 ccr2_on_gp10.58150NoNoYesNo99
46G.H3.17 b.l27x1 ccr2_on_gp10.26230YesNoYesNo59
47G.H3.15 G.H3.17 ccr2_on_gp28.85710NoNoYesNo85
48G.H3.15 G.H3.18 ccr2_on_gp29.04020NoNoYesNo89
49G.H3.18 G.S4.02 ccr2_on_gp29.11530YesNoYesNo98
50G.S1.07 G.S4.02 ccr2_on_gp29.36620YesNoYesNo98
51G.S4.04 G.S4.06 ccr2_on_gp49.12130YesNoNoNo97
52G.H3.05 G.S4.06 ccr2_on_gp50.15610NoNoNoNo97
53G.H3.05 G.s1h1.02 ccr2_on_gp50.16190NoNoYesNo97
54G.S1.04 G.S3.03 ccr2_on_gp26.15380YesNoYesNo77
55G.H5.11 G.S3.03 ccr2_on_gp25.67070NoNoYesNo87
56G.S4.03 G.S5.03 ccr2_on_gp43.2440YesNoYesNo78
57G.S5.03 G.S6.02 ccr2_on_gp43.32630YesNoYesNo87
58G.H2.07 b.l9x6 ccr2_on_gp18.1580YesNoYesNo98
59G.H2.07 G.h2s4.01 ccr2_on_gp30.2750YesNoYesNo99
60b.l11x1 b.l9x6 ccr2_on_gp18.68210YesNoYesNo98
61b.l7x2 b.l9x6 ccr2_on_gp18.70550YesNoYesNo98
62G.h2s4.01 b.l7x2 ccr2_on_gp28.83040YesNoYesNo99
63G.H2.03 G.H2.07 ccr2_on_gp12.1180YesNoYesNo99
64G.H2.06 b.l9x6 ccr2_on_gp16.52980YesNoYesNo98
65b.b6x1 b.l7x2 ccr2_on_gp10.73960NoNoYesNo99
66b.b6x1 b.l7x1 ccr2_on_gp10.89530NoNoNoNo99
67b.b7x5 b.l7x1 ccr2_on_gp10.79120NoNoNoNo99
68b.b6x2 b.b7x5 ccr2_on_gp10.79320NoNoNoNo89
69b.b10x2 b.b6x2 ccr2_on_gp10.74540YesNoNoNo68
70b.b10x2 b.b14x3 ccr2_on_gp10.11720YesNoYesNo65
71b.l17x5 b.l17x6 ccr2_on_gp15.45690NoNoYesNo69
72b.l17x5 b.l19x2 ccr2_on_gp26.35810NoNoYesNo69
73b.b19x6 b.l19x2 ccr2_on_gp12.59910NoNoYesNo99
74b.b19x6 b.l17x3 ccr2_on_gp11.34140NoNoYesNo99
75b.b17x7 b.b20x6 ccr2_on_gp18.37970YesNoYesNo86
76G.H2.06 b.l17x6 ccr2_on_gp11.81520YesNoYesNo99
77G.H2.06 b.l19x1 ccr2_on_gp11.81530YesNoYesNo99
78b.l17x5 b.l19x1 ccr2_on_gp11.56510NoNoYesNo69
79b.b20x2 b.l19x2 ccr2_on_gp12.49170NoNoYesNo69
80b.b20x2 b.b20x4 ccr2_on_gp11.16080NoNoYesNo68
81G.H3.17 b.l25x6 ccr2_on_gp18.36520YesNoNoNo58
82b.l23x1 b.l25x6 ccr2_on_gp19.01470YesNoNoNo68
83b.b11x6 b.l11x1 ccr2_on_gp17.06680NoNoYesNo99
84b.b11x6 b.l9x3 ccr2_on_gp16.0320NoNoYesNo99
85b.b17x5 b.b17x7 ccr2_on_gp12.1520YesNoYesNo78
863x53 I2x57 ccr2_on_gp19.8270NoNoYesNo87
876x48 6x51 Shared25.198626.7226YesYesYesYes96
886x51 7x38 Shared21.961230.5437YesYesYesNo65
897x38 Lig Shared21.542421.68YesNoYesYes50
902x53 7x46 Shared16.249125.5638YesNoNoNo68
912x53 3x32 Shared13.141617.1511YesNoYesYes66
923x42 4x50 Shared14.680812.3591YesYesYesYes79
936x44 6x48 Shared15.406912.1398YesYesYesYes99
943x36 6x48 Shared12.142714.6642YesYesYesYes79
951x35 Lig ccr2_off024.0291NoYesYesYes60
961x35 1x39 ccr2_off0.23313612.096NoYesYesYes67
977x42 Lig ccr2_off014.3385YesYesYesYes70
981x39 7x42 ccr2_off1.3704425.9208YesYesYesYes77
991x35 2x64 ccr2_off010.0476NoYesNoNo65
1001x39 2x57 ccr2_off028.4578YesYesNoNo77
1011x42 2x57 ccr2_off0.23218524.9436NoNoNoNo77
1021x42 7x47 ccr2_off014.326NoNoNoNo78
1031x46 7x47 ccr2_off0.22782910.7617NoNoNoNo88
1042x54 7x46 ccr2_off024.1669NoNoNoNo68
1051x47 2x54 ccr2_off011.8329NoYesNoNo66
1061x50 2x54 ccr2_off0.91103913.092YesNoNoNo96
1073x33 Lig ccr2_off041.2804YesYesYesYes50
1083x33 3x37 ccr2_off075.094YesYesYesYes57
1093x37 5x46 ccr2_off2.43681100YesYesNoNo74
1103x41 5x46 ccr2_off098.1709NoYesNoNo54
1113x41 4x49 ccr2_off095.446NoYesNoNo57
1123x45 4x49 ccr2_off0.29010984.4087YesNoNoNo67
1132x42 3x45 ccr2_off0.58359383.3375YesYesYesNo76
1142x42 3x46 ccr2_off0.33585373.0393YesYesNoNo79
1152x43 3x46 ccr2_off045.4899NoNoNoNo89
1161x57 2x43 ccr2_off0.3122644.0366YesNoNoNo78
1171x57 2x40 ccr2_off2.1847135.1917YesNoNoYes78
1182x40 I1x48 ccr2_off022.7449NoYesNoNo86
1193x42 4x49 ccr2_off0.30422217.5332YesYesNoNo77
1203x36 3x37 ccr2_off9.844558.6382YesYesYesYes77
1213x36 6x44 ccr2_off031.0887YesYesYesYes79
1226x44 6x45 ccr2_off024.4926YesYesNoYes95
1236x41 6x45 ccr2_off019.2496NoNoNoYes85
1243x43 6x41 ccr2_off015.8168NoNoNoNo88
1252x60 Lig ccr2_off6.4945320.0138YesYesYesYes60
1262x60 E1x50 ccr2_off018.7422YesYesYesYes68
127E1x50 E1x52 ccr2_off010.9121YesYesNoNo87
1283x33 4x61 ccr2_off028.3576YesYesNoYes54
1294x61 E2 ccr2_off1.0990823.766NoYesYesYes43
130E1x50 E2 ccr2_off2.2068714.0692YesYesYesYes83
1313x40 6x44 ccr2_off5.2353718.3099NoNoYesYes89
1323x40 5x50 ccr2_off016.3054NoNoYesYes88
1333x43 6x40 ccr2_off012.5094NoNoNoYes88
1343x44 5x50 ccr2_off0.045835710.2167YesNoYesYes88
1353x46 6x37 ccr2_off033.3312NoNoNoNo97
1365x58 6x37 ccr2_off0.4733631.7402YesNoNoNo87
1373x47 5x58 ccr2_off0.74760725.5763YesNoYesNo98
1383x47 5x57 ccr2_off0.063814223.9414YesNoNoNo97
1393x51 5x57 ccr2_off0.20254922.2939NoNoNoNo87
1403x51 3x55 ccr2_off1.0024718.8925NoNoNoYes87
1413x55 5x61 ccr2_off010.4109NoYesYesYes78
1426x51 6x55 ccr2_off2.2466617.6773YesYesNoNo66
1435x40 6x55 ccr2_off1.8723616.1927NoYesNoNo56
1445x43 6x51 ccr2_off012.6973YesNoYesYes56
1456x51 7x37 ccr2_off0.79792226.4032YesYesNoNo67
1466x29 I1x48 ccr2_off013.236NoNoNoNo46
1476x54 7x37 ccr2_off022.5319NoNoNoNo57
1486x54 7x34 ccr2_off1.1872218.1158NoNoNoNo54
1496x58 7x34 ccr2_off015.8983NoNoNoNo44
1506x58 7x30 ccr2_off013.662NoNoNoNo44
1512x37 2x40 ccr2_off1.2487610.1917YesNoNoYes78
1523x32 7x42 ccr2_off010.9935YesYesYesYes67
1533x32 3x33 ccr2_off0.16453620.8281YesYesYesYes65
1543x32 7x38 ccr2_off0.030986710.0413YesYesYesNo65
1553x36 5x43 ccr2_off6.6845912.9291YesYesYesNo75

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
1x277x32Shared8.61.430222
1x31Ligccr2_off6.1900010
1x341x35ccr2_off4.1500021
1x351x39Shared16.4116.411011
1x357x39ccr2_off4.4201012
1x35Ligccr2_off12.5301010
1x392x57ccr2_off7.0301212
1x397x39ccr2_off6.2401212
1x397x42Shared11.978.381211
2x533x32Shared9.2812.381021
2x537x42Shared4.983.731021
2x562x60Shared7.287.280221
2x563x28Shared6.493.890222
2x60E1x50ccr2_off4.6901212
2x607x42ccr2_off4.6501211
2x60LigShared15.822.081210
2x63E1x50Shared6.184.940022
3x25E1x50Shared3.923.921222
E1x50E2Shared6.185.851221
E1x50E2x50Shared16.989.141221
3x22E2Shared7.523.150221
3x25E2x50Shared7.287.281221
3x26E2ccr2_off7.1800021
3x294x65Shared10.9914.130211
3x29LigShared7.1112.760210
3x323x33Shared8.712.181211
3x327x38Shared4.495.611211
3x327x42ccr2_off4.7901211
3x32LigShared7.789.741210
3x333x37ccr2_off5.6601012
3x334x57Shared4.182.791012
3x334x61ccr2_off25.5101012
3x33Ligccr2_off4.6501010
4x61E2Shared6.043.011221
4x615x39ccr2_off8.9301222
4x64E2Shared16.087.51221
E2E2Shared4148.581211
E2x51E2x52Shared4.064.060211
5x36E2Shared4.836.041211
5x39E2Shared4.5312.441221
5x366x59ccr2_off4.3901212
5x436x51ccr2_off7.200222
6x517x38Shared8.9811.220021
6x547x34Shared4.763.170021
6x587x30ccr2_off4.1200022
6x587x34ccr2_off4.3900021
6x617x27Shared8.52.830211
7x35LigShared11.243.030210
7x38LigShared17.596.291210
7x42Ligccr2_off5.1201010
1x30Ligccr2_off3.4400010
1x352x64ccr2_off3.1501012
E2E2x52ccr2_off2.8901211
1x277x35ccr2_off2.8700221
E1x49E2ccr2_off2.8500021
7x36Ligccr2_off2.700010
1x392x61Shared2.672.671212
1x271x28ccr2_off1.5200221
6x617x30ccr2_off1.3300212
7x317x35ccr2_off1.3100211
LigNTccr2_on_gp023.951201
NTNTccr2_on_gp012.280211
E3NTccr2_on_gp07.280211
1x27NTccr2_on_gp05.760221
7x31NTccr2_on_gp05.040211
1x277x31ccr2_on_gp02.920221
1x282x66ccr2_on_gp011.190212
1x317x35ccr2_on_gp04.930011
1x357x35ccr2_on_gp07.991011
1x39Ligccr2_on_gp04.111210
2x577x42ccr2_on_gp02.830021
2x602x63ccr2_on_gp02.471212
2x603x28ccr2_on_gp021212
3x28E1x50ccr2_on_gp03.010222
3x223x26ccr2_on_gp02.80222
3x264x65ccr2_on_gp030021
3x293x30ccr2_on_gp01.820212
3x293x33ccr2_on_gp02.740211
3x335x43ccr2_on_gp04.511012
3x374x57ccr2_on_gp02.640222
3x375x43ccr2_on_gp03.210222
4x614x65ccr2_on_gp01.821221
4x65Ligccr2_on_gp02.830210
E2Ligccr2_on_gp012.571210
E2x50Ligccr2_on_gp06.11210
E2x51Ligccr2_on_gp06.630210
E2x52Ligccr2_on_gp014.561210
5x36Ligccr2_on_gp07.451210
5x395x43ccr2_on_gp05.641222
6x586x61ccr2_on_gp03.960021
6x61E3ccr2_on_gp02.890211
6x61Ligccr2_on_gp08.570210
E3Ligccr2_on_gp08.90210
7x26E3ccr2_on_gp05.960021
7x27Ligccr2_on_gp012.480210
7x31Ligccr2_on_gp04.630210
7x34Ligccr2_on_gp04.340210
7x387x42ccr2_on_gp06.771211
1x28Ligccr2_on_gp01.610210
1x291x30ccr2_on_gp01.370021
1x307x32ccr2_on_gp01.370012

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
ccr2_on_gp 7XA3-CCR2-CCL2-Gi1/β1/γ2
ccr2_off 6GPS-CCR2-MK0812
Network Difference
Value ccr2_on_gp ccr2_off
Imin 1.72 3.89
Number of Linked Nodes 835 246
Number of Specific Nodes 608 (72.81%) 19  (7.72%)
Number of Shared Nodes 227 (27.19%) 227  (92.28%)
Number of Links 1114 265
Number of Specific Links 982 (88.15%) 133  (50.19%)
Number of Shared Links 132 (11.85%) 132  (49.81%)
Number of Hubs 208 35
Number of Specific Hubs 186 (89.42%) 13  (37.14%)
Number of Shared Hubs 22 (10.58%) 22  (62.86%)
Average % Shared Neighbours (Jaccard) 10.04
Average % Shared Neighbours (Otsuka) 12.79
Average % Shared Neighbours (Overlap Coefficient) 15.61
Average % Shared Cliques (k3-6) 50.62
Graphlets Similarity 0.634882
Paths Difference
Value ccr2_on_gp ccr2_off
Number Of Nodes in MetaPath 90 63
Specific Nodes in MetaPath 73 (81.11%) 46  (73.02%)
Shared Nodes in MetaPath 227 (27.19%) 227  (27.19%)
Number Of Links MetaPath 94 69
Specific Links in MetaPath 86 (91.49%) 61  (88.41%)
Shared Links in MetaPath 132 (11.85%) 132  (11.85%)
Number of Shortest Paths 3865614 34912
Length Of Smallest Path 3 3
Average Path Length 32.2551 12.4178
Length of Longest Path 56 27
Minimum Path Strength 1.265 1.355
Average Path Strength 5.23066 6.84733
Maximum Path Strength 21.92 17.11
Minimum Path Correlation 0.7 0.7
Average Path Correlation 0.991518 0.914569
Maximum Path Correlation 1 0.99
Minimum % Of Corr. Nodes 2.5 4.34783
Average % Of Corr. Nodes 37.5901 49.5827
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 60.595 44.1211
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download ccr2_off_on_gp.zip<



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