psnGPCR

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Orange: nodes, hubs and links specific of ccr5_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccr5_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ccr5_off Int. Strength	ccr5_on Int. Strength	ccr5_off Hub1?	ccr5_on Hub1?	ccr5_off Hub2?	ccr5_on Hub2?	ConSurf1	ConSurf2
1	4x65	Lig	ccr5_off	6.99	0	No	No	Yes	Yes	5	0
2	7x38	Lig	ccr5_off	7.37	0	No	No	Yes	Yes	6	0
3	1x31	Lig	ccr5_off	4.73	0	No	No	Yes	Yes	5	0
4	Lig	NT.C20	ccr5_off	4.19	0	Yes	Yes	No	No	0	9
5	E2.K171	Lig	ccr5_off	10.8	0	No	No	Yes	Yes	2	0
6	E2.G173	Lig	ccr5_off	5.12	0	No	No	Yes	Yes	1	0
7	7x28	NT.C20	ccr5_off	4.72	0	No	No	No	No	1	9
8	1x24	7x31	ccr5_off	6.91	0	No	Yes	No	No	3	4
9	1x25	1x29	ccr5_off	9.61	0	No	No	No	No	3	2
10	1x35	7x39	ccr5_off	5.9	0	No	No	No	No	6	6
11	1x49	7x50	ccr5_off	4.06	0	No	No	No	No	8	9
12	1x51	2x51	ccr5_off	5.65	0	No	No	No	No	3	7
13	1x53	7x53	ccr5_off	5.05	0	No	No	Yes	Yes	8	9
14	1x54	2x44	ccr5_off	4.28	0	No	No	No	No	7	6
15	1x56	8x53	ccr5_off	4.84	0	No	No	No	No	7	5
16	1x60	CT.K314	ccr5_off	5.97	0	Yes	No	No	No	5	6
17	2x37	2x40	ccr5_off	7.36	0	No	No	No	No	7	8
18	2x38	I2x57	ccr5_off	6.2	0	No	No	Yes	Yes	6	6
19	2x43	3x46	ccr5_off	4.15	0	No	No	No	No	8	9
20	2x43	7x53	ccr5_off	4.69	0	No	No	Yes	Yes	8	9
21	2x52	4x50	ccr5_off	9.02	0	No	No	Yes	No	7	9
22	2x54	7x46	ccr5_off	4.76	0	No	No	No	No	6	8
23	2x56	2x60	ccr5_off	9.7	0	No	No	Yes	No	7	7
24	2x60	E1x50	ccr5_off	6.56	0	Yes	No	Yes	Yes	7	9
25	2x60	3x32	ccr5_off	5.79	0	Yes	No	Yes	Yes	7	7
26	2x60	7x42	ccr5_off	4.65	0	Yes	No	No	Yes	7	8
27	2x62	E1x51	ccr5_off	8.82	0	No	No	No	No	5	3
28	2x63	E2.H175	ccr5_off	6.53	0	Yes	Yes	No	No	4	1
29	2x63	E2x50	ccr5_off	4.03	0	Yes	Yes	No	No	4	9
30	E1x49	E2.Y176	ccr5_off	12.4	0	No	No	No	No	3	4
31	3x22	E2.S169	ccr5_off	7.45	0	Yes	No	No	No	3	4
32	3x24	3x28	ccr5_off	4.24	0	No	No	No	No	6	5
33	3x37	4x56	ccr5_off	4.16	0	Yes	Yes	No	No	7	5
34	3x37	4x57	ccr5_off	5.28	0	Yes	Yes	No	No	7	7
35	3x37	5x46	ccr5_off	4.87	0	Yes	Yes	No	No	7	4
36	3x40	3x43	ccr5_off	4.42	0	Yes	No	No	No	7	8
37	3x40	3x44	ccr5_off	4.42	0	Yes	No	Yes	No	7	7
38	3x40	5x50	ccr5_off	6.77	0	Yes	No	Yes	No	7	9
39	3x42	4x46	ccr5_off	3.96	0	Yes	Yes	No	No	7	7
40	3x43	6x40	ccr5_off	4.42	0	No	No	No	No	8	8
41	3x43	6x41	ccr5_off	4.37	0	No	No	Yes	No	8	8
42	3x47	6x41	ccr5_off	4.52	0	No	No	Yes	No	9	8
43	3x50	3x53	ccr5_off	4.15	0	No	No	No	No	9	8
44	3x50	6x33	ccr5_off	15.48	0	No	No	No	No	9	8
45	3x51	3x56	ccr5_off	4.36	0	Yes	No	No	No	8	6
46	3x51	5x61	ccr5_off	4.84	0	Yes	No	Yes	No	8	8
47	3x54	6x30	ccr5_off	6.54	0	No	No	No	No	8	7
48	4x60	5x39	ccr5_off	6.32	0	No	No	Yes	No	8	5
49	4x61	5x39	ccr5_off	9.24	0	No	No	Yes	No	4	5
50	4x61	5x42	ccr5_off	5.6	0	No	No	No	No	4	3
51	4x64	5x39	ccr5_off	7.03	0	Yes	Yes	Yes	No	5	5
52	E2.E172	E2.Q170	ccr5_off	12.74	0	No	No	No	No	2	1
53	E2.E172	E2.T177	ccr5_off	16.93	0	No	No	Yes	No	2	2
54	E2.H175	E2.T177	ccr5_off	6.85	0	No	No	Yes	No	1	2
55	E2.H181	E2x51	ccr5_off	5.58	0	No	No	No	No	4	3
56	E2.F182	E2x52	ccr5_off	6.61	0	Yes	Yes	No	No	5	4
57	5x36	E2.F182	ccr5_off	6.2	0	No	No	Yes	Yes	4	5
58	5x35	E2.P183	ccr5_off	8.11	0	Yes	Yes	No	No	3	3
59	E2.S185	E2.Y184	ccr5_off	6.36	0	No	No	No	No	3	1
60	5x33	5x37	ccr5_off	11.88	0	No	No	No	No	2	3
61	5x34	5x38	ccr5_off	4.29	0	No	No	No	No	1	3
62	5x39	5x42	ccr5_off	6.78	0	Yes	No	No	No	5	3
63	5x40	6x55	ccr5_off	4.42	0	No	No	No	Yes	5	6
64	5x50	6x45	ccr5_off	5.78	0	Yes	No	Yes	No	9	5
65	5x54	6x41	ccr5_off	5.78	0	No	No	Yes	No	8	8
66	5x54	6x45	ccr5_off	4.98	0	No	No	Yes	No	8	5
67	5x58	6x38	ccr5_off	10.32	0	Yes	Yes	No	No	9	5
68	5x62	5x66	ccr5_off	5.54	0	No	No	No	No	4	4
69	5x65	6x34	ccr5_off	4.47	0	No	No	No	No	8	6
70	6x27	6x28	ccr5_off	5.4	0	No	No	No	No	3	5
71	6x29	6x33	ccr5_off	15.21	0	No	No	No	No	6	8
72	6x32	8x48	ccr5_off	4.65	0	No	No	No	No	7	5
73	6x35	7x56	ccr5_off	3.92	0	No	No	No	No	5	7
74	6x36	6x37	ccr5_off	4.28	0	No	No	No	No	8	8
75	6x38	6x42	ccr5_off	6.28	0	No	No	No	No	5	5
76	6x39	7x52	ccr5_off	4.56	0	No	No	No	No	5	8
77	6x40	7x53	ccr5_off	4.84	0	No	No	Yes	Yes	8	9
78	6x41	6x45	ccr5_off	6.22	0	Yes	No	Yes	No	8	5
79	6x44	6x45	ccr5_off	5.16	0	Yes	Yes	Yes	No	9	5
80	6x47	7x48	ccr5_off	10.05	0	No	Yes	Yes	No	8	6
81	6x48	6x51	ccr5_off	6.75	0	Yes	Yes	Yes	No	9	7
82	6x58	6x61	ccr5_off	6.6	0	No	No	No	No	4	4
83	6x61	E3.N267	ccr5_off	3.96	0	No	No	Yes	No	4	3
84	6x63	6x64	ccr5_off	11.79	0	No	No	No	No	1	1
85	7x30	E3.L266	ccr5_off	5.54	0	No	No	No	No	5	4
86	7x35	7x38	ccr5_off	11.47	0	No	No	No	No	3	6
87	7x35	7x39	ccr5_off	5.67	0	No	No	No	No	3	6
88	7x45	7x48	ccr5_off	5.3	0	Yes	No	Yes	No	9	6
89	7x45	7x49	ccr5_off	5.1	0	Yes	No	No	Yes	9	9
90	7x53	8x50	ccr5_off	5.16	0	Yes	Yes	Yes	Yes	9	8
91	8x50	8x54	ccr5_off	4.87	0	Yes	Yes	No	No	8	6
92	8x56	8x59	ccr5_off	4.3	0	No	No	No	No	4	3
93	1x39	2x57	ccr5_off	3.79	0	Yes	Yes	No	No	8	7
94	7x56	8x47	ccr5_off	3.68	0	No	No	No	No	7	8
95	4x55	4x59	ccr5_off	3.65	0	No	No	No	No	4	4
96	5x54	5x58	ccr5_off	3.59	0	No	No	Yes	Yes	8	9
97	1x38	1x39	ccr5_off	3.52	0	No	No	Yes	Yes	6	8
98	3x25	E2.S169	ccr5_off	3.44	0	No	No	No	No	9	4
99	8x57	8x58	ccr5_off	3.22	0	No	No	No	No	4	5
100	1x42	7x43	ccr5_off	3.17	0	No	No	No	No	7	5
101	6x39	7x56	ccr5_off	3.17	0	No	No	No	No	5	7
102	1x35	2x64	ccr5_off	3.15	0	No	No	No	No	6	5
103	2x41	4x39	ccr5_off	3.07	0	No	No	No	No	7	2
104	5x61	6x34	ccr5_off	3.07	0	Yes	No	No	No	8	6
105	1x53	1x57	ccr5_off	2.98	0	No	No	No	No	8	7
106	1x38	7x43	ccr5_off	2.95	0	No	No	No	No	6	5
107	1x54	1x58	ccr5_off	2.94	0	No	No	No	No	7	3
108	7x48	7x52	ccr5_off	2.94	0	Yes	No	No	No	6	8
109	2x62	2x66	ccr5_off	2.93	0	No	No	No	No	5	4
110	1x30	1x34	ccr5_off	2.85	0	No	No	No	No	2	6
111	3x48	3x52	ccr5_off	2.85	0	No	No	No	No	7	5
112	5x43	6x52	ccr5_off	2.83	0	No	No	No	No	5	8
113	3x21	E1x50	ccr5_off	2.81	0	No	No	Yes	Yes	8	9
114	1x52	8x54	ccr5_off	2.77	0	No	No	No	No	6	6
115	1x50	2x51	ccr5_off	2.75	0	No	No	No	No	9	7
116	3x26	4x62	ccr5_off	2.74	0	No	No	No	No	7	4
117	1x60	8x56	ccr5_off	2.52	0	Yes	No	No	No	5	4
118	6x29	6x32	ccr5_off	2.48	0	No	No	No	No	6	7
119	6x64	E3.L266	ccr5_off	2.44	0	No	No	No	No	1	4
120	5x461	5x50	ccr5_off	2.03	0	No	No	Yes	No	6	9
121	1x46	7x47	ccr5_off	1.96	0	No	No	No	No	8	8
122	6x49	6x50	ccr5_off	1.87	0	No	No	No	No	6	9
123	3x35	3x38	ccr5_off	1.86	0	No	No	No	No	8	7
124	E2.G173	E2.L174	ccr5_off	1.71	0	No	No	No	No	1	4
125	6x65	E3.N267	ccr5_off	1.7	0	No	No	Yes	No	4	3
126	8x47	8x49	ccr5_off	1.64	0	No	No	No	No	8	6
127	NT.S17	NT.T16	ccr5_off	1.6	0	No	No	No	No	4	2
128	5x44	5x48	ccr5_off	1.6	0	No	No	No	No	5	4
129	4x44	4x45	ccr5_off	1.59	0	No	No	No	No	1	6
130	1x45	1x46	ccr5_off	1.51	0	No	No	No	No	5	8
131	3x22	3x23	ccr5_off	1.46	0	Yes	No	No	No	3	3
132	3x24	3x27	ccr5_off	1.41	0	No	No	No	No	6	5
133	5x65	5x66	ccr5_off	1.38	0	No	No	No	No	8	4
134	1x25	NT.Q21	ccr5_off	1.37	0	No	No	No	No	3	1
135	4x41	4x44	ccr5_off	1.31	0	No	No	No	No	3	1
136	6x28	6x32	ccr5_off	1.24	0	No	No	No	No	5	7
137	1x59	I1x49	ccr5_off	1.21	0	No	No	No	No	4	5
138	6x31	6x35	ccr5_off	1.13	0	No	No	No	No	5	5
139	Lig	Lig	Shared	502.27	402.16	Yes	Yes	Yes	Yes	0	0
140	E2x52	Lig	Shared	16.77	3.93	No	No	Yes	Yes	4	0
141	E2.F182	Lig	Shared	7.13	4.81	Yes	Yes	Yes	Yes	5	0
142	5x40	Lig	Shared	7.88	3.94	No	No	Yes	Yes	5	0
143	6x55	Lig	Shared	4.44	5.19	No	Yes	Yes	Yes	6	0
144	2x60	Lig	Shared	28.37	22.76	Yes	No	Yes	Yes	7	0
145	3x29	Lig	Shared	8.74	7.785	No	No	Yes	Yes	5	0
146	3x32	Lig	Shared	13.91	8.93	Yes	Yes	Yes	Yes	7	0
147	2x63	Lig	Shared	7.03	7.62	Yes	Yes	Yes	Yes	4	0
148	7x35	Lig	Shared	17.85	7.825	No	No	Yes	Yes	3	0
149	E2x51	Lig	Shared	18.05	9.4	No	No	Yes	Yes	3	0
150	1x24	Lig	Shared	8.85	5.41	No	Yes	Yes	Yes	3	0
151	7x31	Lig	Shared	11.22	8.03	No	No	Yes	Yes	4	0
152	7x34	Lig	Shared	7.88	5.135	No	Yes	Yes	Yes	5	0
153	1x28	Lig	Shared	4.23	12.945	No	No	Yes	Yes	1	0
154	E2.E172	Lig	Shared	22.59	25.895	No	No	Yes	Yes	2	0
155	E2.T177	Lig	Shared	4.25	4.245	Yes	No	Yes	Yes	2	0
156	Lig	NT.P19	Shared	22.31	13.22	Yes	Yes	No	No	0	4
157	6x61	Lig	Shared	11.28	5.05	No	No	Yes	Yes	4	0
158	E3.N267	Lig	Shared	7.17	2.7	Yes	No	Yes	Yes	3	0
159	7x27	Lig	Shared	5.28	3.96	No	No	Yes	Yes	3	0
160	Lig	NT.S17	Shared	11.04	3.26	Yes	Yes	No	No	0	4
161	E2.Q170	Lig	Shared	5.86	9.04	No	No	Yes	Yes	1	0
162	E2.Y184	Lig	Shared	22.88	20.515	No	No	Yes	Yes	1	0
163	5x32	Lig	Shared	23.77	20.085	No	No	Yes	Yes	3	0
164	7x24	NT.C20	Shared	7.28	7.28	No	No	No	No	6	9
165	1x24	1x27	Shared	19.73	3.795	No	Yes	No	No	3	1
166	1x25	1x26	Shared	4.25	1.415	No	No	No	No	3	1
167	1x27	7x32	Shared	7.16	5.015	No	No	No	No	1	1
168	1x35	1x39	Shared	9.38	13.48	No	No	Yes	Yes	6	8
169	1x36	1x37	Shared	5.84	5.84	No	No	No	No	6	5
170	1x39	7x39	Shared	11.24	4.37	Yes	Yes	No	No	8	6
171	1x39	7x42	Shared	14.37	6.585	Yes	Yes	No	Yes	8	8
172	1x41	1x45	Shared	8.53	2.435	No	No	No	No	5	5
173	1x43	2x58	Shared	13	13.725	No	No	No	No	7	9
174	1x47	1x51	Shared	7.46	5.595	No	Yes	No	No	6	3
175	1x50	2x50	Shared	12.12	10.77	No	No	No	Yes	9	9
176	1x50	7x50	Shared	9.77	8.145	No	No	No	No	9	9
177	1x53	8x50	Shared	3.93	5.895	No	No	Yes	Yes	8	8
178	1x56	8x50	Shared	6.28	10.045	No	No	Yes	Yes	7	8
179	1x58	1x59	Shared	8.5	4.245	No	No	No	No	3	4
180	1x60	8x57	Shared	7.22	2.795	Yes	No	No	No	5	4
181	2x40	I1x48	Shared	8.3	11.06	No	No	No	No	8	5
182	8x53	I1x48	Shared	5.97	13.735	No	No	No	No	5	5
183	2x41	I1x50	Shared	5.71	3.57	No	No	No	No	7	6
184	2x44	I1x50	Shared	4.15	2.77	No	No	No	No	6	6
185	2x40	I1x51	Shared	5.53	6.915	No	No	No	No	8	7
186	2x38	2x42	Shared	11.97	11.375	No	No	Yes	Yes	6	7
187	2x38	3x49	Shared	9.7	4.16	No	No	No	Yes	6	8
188	2x39	3x49	Shared	7.23	9.395	No	No	No	Yes	8	8
189	2x42	3x45	Shared	10.55	9.375	Yes	Yes	No	No	7	6
190	2x42	4x42	Shared	4.35	4.35	Yes	Yes	No	No	7	7
191	2x42	4x45	Shared	7.49	6.245	Yes	Yes	No	No	7	6
192	2x45	3x42	Shared	16.92	13.895	No	No	Yes	Yes	9	7
193	2x45	4x46	Shared	7.45	7.45	No	No	No	No	9	7
194	2x45	4x50	Shared	6.78	4.52	No	No	Yes	No	9	9
195	2x46	7x49	Shared	4.12	8.24	No	No	No	Yes	9	9
196	2x49	3x38	Shared	6.52	6.52	No	No	No	No	8	7
197	2x50	7x49	Shared	6.73	6.735	No	Yes	No	Yes	9	9
198	2x53	3x32	Shared	10.32	15.475	No	Yes	Yes	Yes	7	7
199	2x53	7x42	Shared	4.98	5.595	No	Yes	No	Yes	7	8
200	2x53	7x46	Shared	5.59	7.68	No	Yes	No	No	7	8
201	2x59	E1x52	Shared	9.65	6.43	No	No	No	Yes	6	7
202	2x59	3x28	Shared	13.4	10.355	No	No	No	No	6	5
203	2x62	E1x52	Shared	9.05	2.83	No	No	No	Yes	5	7
204	2x63	E1x50	Shared	9.65	9.165	Yes	Yes	Yes	Yes	4	9
205	2x63	E2.T177	Shared	4.99	4.37	Yes	Yes	Yes	No	4	2
206	E1x49	E1x51	Shared	7.83	3.92	No	No	No	No	3	3
207	E1x49	E2.H175	Shared	11.13	7.42	No	No	No	No	3	1
208	E1x50	E1x52	Shared	14.03	19.54	Yes	Yes	No	Yes	9	7
209	3x25	E1x50	Shared	5.22	7.185	No	No	Yes	Yes	9	9
210	E1x50	E2x50	Shared	16.98	11.1	Yes	Yes	No	No	9	9
211	3x22	3x26	Shared	9.24	8.58	Yes	No	No	No	3	7
212	3x22	E2.R168	Shared	13.26	3.615	Yes	No	No	No	3	4
213	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
214	3x29	4x65	Shared	14.13	8.635	No	No	No	No	5	5
215	3x32	3x33	Shared	8.25	5.67	Yes	Yes	No	No	7	5
216	3x33	3x37	Shared	5.36	5.36	No	No	Yes	Yes	5	7
217	3x33	4x61	Shared	19.33	11.775	No	No	No	No	5	4
218	3x34	4x57	Shared	4.64	5.415	No	No	No	No	5	7
219	3x36	3x37	Shared	9.65	8.575	No	Yes	Yes	Yes	7	7
220	3x36	6x48	Shared	10.02	6.015	No	Yes	Yes	Yes	7	9
221	3x37	3x41	Shared	4.29	3.215	Yes	Yes	Yes	Yes	7	5
222	3x38	4x50	Shared	8.65	10.505	No	No	Yes	No	7	9
223	3x40	6x44	Shared	16.92	4.235	Yes	No	Yes	Yes	7	9
224	3x41	4x49	Shared	3.89	4.54	Yes	Yes	No	No	5	6
225	3x41	4x52	Shared	3.93	1.965	Yes	Yes	No	No	5	4
226	3x42	4x49	Shared	6.49	9.08	Yes	Yes	No	No	7	6
227	3x42	4x50	Shared	8.02	8.02	Yes	Yes	Yes	No	7	9
228	3x44	5x50	Shared	5.08	5.93	Yes	No	Yes	No	7	9
229	3x44	5x53	Shared	4.61	4.61	Yes	No	No	No	7	6
230	3x45	4x49	Shared	4.42	4.42	No	No	No	No	6	6
231	3x49	I2x57	Shared	13.1	14.295	No	Yes	Yes	Yes	8	6
232	3x51	3x55	Shared	16.4	11.355	Yes	No	No	No	8	7
233	3x51	5x57	Shared	10.75	8.065	Yes	No	No	No	8	8
234	3x53	I2x57	Shared	6.91	3.455	No	No	Yes	Yes	8	6
235	3x55	3x56	Shared	8.3	6.225	No	No	No	No	7	6
236	I2x52	I2x56	Shared	4.16	2.775	No	No	No	No	5	4
237	4x38	4x40	Shared	4.71	3.14	No	No	No	No	6	4
238	4x64	E2.F182	Shared	10.72	5.895	Yes	Yes	Yes	Yes	5	5
239	4x64	5x35	Shared	15.03	13.53	Yes	Yes	Yes	Yes	5	3
240	E2.H181	E2.Q170	Shared	11.13	11.745	No	No	No	No	4	1
241	E2.K171	E2.Y176	Shared	17.91	7.765	No	No	No	No	2	4
242	5x31	E2.S185	Shared	5.78	3.61	No	No	No	No	3	3
243	5x31	5x35	Shared	4.38	8.215	No	No	Yes	Yes	3	3
244	5x32	5x36	Shared	8.36	6.57	No	No	No	No	3	4
245	5x34	5x35	Shared	18.04	12.03	No	No	Yes	Yes	1	3
246	5x35	5x38	Shared	6.01	8.02	Yes	Yes	No	No	3	3
247	5x37	6x60	Shared	7.25	5.44	No	No	No	No	3	5
248	5x40	6x59	Shared	14.13	12.56	No	No	No	Yes	5	5
249	5x44	6x52	Shared	4.43	3.695	No	No	No	No	5	8
250	5x44	6x56	Shared	7.45	2.235	No	No	No	No	5	5
251	5x47	6x52	Shared	5.49	10.98	No	No	No	No	8	8
252	5x51	6x45	Shared	8.53	2.435	No	No	Yes	No	6	5
253	5x52	5x56	Shared	4.28	0.715	No	No	No	No	4	4
254	5x58	5x61	Shared	4.84	3.63	Yes	Yes	Yes	No	9	8
255	6x43	7x52	Shared	4.61	3.84	No	No	No	No	6	8
256	6x44	6x48	Shared	14.47	12.54	Yes	Yes	Yes	Yes	9	9
257	6x44	7x45	Shared	4.36	5.99	Yes	Yes	Yes	No	9	9
258	6x47	7x40	Shared	4.87	5.48	No	Yes	No	No	8	8
259	6x47	7x45	Shared	10.18	9.615	No	Yes	Yes	No	8	9
260	6x48	7x41	Shared	11.26	5.63	Yes	Yes	No	No	9	8
261	6x48	7x45	Shared	6.35	15.34	Yes	Yes	Yes	No	9	9
262	6x51	6x55	Shared	11.72	15.825	Yes	No	No	Yes	7	6
263	6x51	7x37	Shared	4.99	8.74	Yes	No	No	Yes	7	7
264	6x51	7x38	Shared	6.73	13.47	Yes	No	No	No	7	6
265	6x54	7x37	Shared	6.35	4.76	No	No	No	Yes	5	7
266	6x57	6x64	Shared	7.31	5.48	No	No	No	No	4	1
267	6x58	7x30	Shared	5.49	6.18	No	No	No	No	4	5
268	6x58	7x34	Shared	5.61	4.91	No	No	No	Yes	4	5
269	6x59	6x60	Shared	11.67	7.785	No	Yes	No	No	5	5
270	6x62	E3.N267	Shared	13.15	1.315	No	No	Yes	No	3	3
271	7x23	7x25	Shared	4.47	2.235	No	No	No	No	4	1
272	7x23	7x26	Shared	8.94	2.98	No	No	No	No	4	1
273	7x26	7x29	Shared	3.95	1.975	No	No	No	No	1	2
274	8x48	8x51	Shared	4.65	2.91	No	No	No	No	5	8
275	8x55	8x59	Shared	5.32	0.665	No	No	No	No	4	3
276	2x48	2x52	Shared	3.77	5.02	No	No	No	No	6	7
277	3x36	5x43	Shared	3.77	4.395	No	Yes	No	No	7	5
278	1x36	2x64	Shared	3.74	2.805	No	No	No	No	6	5
279	1x36	2x65	Shared	3.74	0.935	No	No	No	No	6	4
280	2x49	3x39	Shared	3.71	3.71	No	No	No	No	8	9
281	5x58	6x37	Shared	3.63	9.67	Yes	Yes	No	No	9	8
282	2x57	2x58	Shared	3.53	5.3	No	No	No	No	7	9
283	3x30	4x62	Shared	3.53	3.53	No	No	No	No	5	4
284	6x50	7x37	Shared	3.5	3.5	No	No	No	Yes	9	7
285	1x46	2x54	Shared	3.42	2.565	No	No	No	No	8	6
286	6x54	7x33	Shared	3.39	2.545	No	No	No	No	5	6
287	5x49	5x50	Shared	3.28	3.28	No	No	Yes	No	6	9
288	1x54	2x47	Shared	3.25	3.25	No	No	No	No	7	9
289	3x54	5x64	Shared	3.17	4.76	No	No	No	No	8	5
290	3x34	4x54	Shared	3.07	5.375	No	No	No	No	5	4
291	3x54	5x61	Shared	3.07	9.985	No	No	Yes	No	8	8
292	7x26	E3.L266	Shared	3	8.26	No	No	No	No	1	4
293	1x60	8x53	Shared	2.98	4.7	Yes	No	No	No	5	5
294	2x56	3x31	Shared	2.95	5.16	No	No	No	No	7	5
295	3x44	3x48	Shared	2.94	2.94	Yes	No	No	No	7	7
296	3x51	5x60	Shared	2.9	1.45	Yes	No	No	No	8	4
297	2x44	2x48	Shared	2.85	3.565	No	No	No	No	6	6
298	6x42	6x46	Shared	2.85	1.425	No	No	No	No	5	5
299	3x41	4x53	Shared	2.77	2.08	Yes	Yes	No	No	5	7
300	I2x53	I2x57	Shared	2.77	2.77	No	No	Yes	Yes	5	6
301	7x54	8x50	Shared	2.77	5.545	No	No	Yes	Yes	7	8
302	1x55	1x59	Shared	2.75	2.06	No	No	No	No	4	4
303	1x39	2x61	Shared	2.67	3.335	Yes	Yes	No	No	8	6
304	4x51	4x55	Shared	2.62	5.895	No	No	No	No	4	4
305	4x38	4x41	Shared	2.59	1.945	No	No	No	No	6	3
306	1x44	1x45	Shared	2.51	3.77	No	No	No	No	5	5
307	4x63	4x64	Shared	2.51	6.91	No	No	Yes	Yes	3	5
308	7x51	7x55	Shared	2.51	6.28	No	No	No	No	6	7
309	2x49	3x35	Shared	1.86	2.785	No	No	No	No	8	8
310	1x48	1x49	Shared	1.84	2.76	No	No	No	No	3	8
311	5x60	5x63	Shared	1.74	1.74	No	No	No	No	4	3
312	4x59	4x60	Shared	1.64	1.64	No	No	No	No	4	8
313	4x39	4x43	Shared	1.6	1.6	No	No	No	No	2	4
314	NT.E18	NT.P19	Shared	1.57	3.93	No	No	No	No	3	4
315	4x48	4x52	Shared	1.54	1.54	No	No	No	No	3	4
316	7x48	7x51	Shared	1.47	3.68	Yes	No	No	No	6	6
317	Lig	NT.Q21	Shared	1.44	6.89	Yes	Yes	No	No	0	1
318	5x41	5x45	Shared	1.43	2.14	No	No	No	No	4	5
319	1x47	2x55	Shared	1.22	1.22	No	Yes	No	No	6	5
320	3x56	I2x52	Shared	1.13	2.83	No	No	No	No	6	5
321	Lig	NT.E18	ccr5_on	0	7.09	Yes	Yes	No	No	0	3
322	1x24	1x28	ccr5_on	0	4.31	No	Yes	No	No	3	1
323	1x24	7x28	ccr5_on	0	7.69	No	Yes	No	No	3	1
324	1x29	1x30	ccr5_on	0	6.175	No	No	No	No	2	2
325	1x31	7x35	ccr5_on	0	4.55	No	No	No	No	5	3
326	1x42	7x42	ccr5_on	0	5.325	No	No	No	Yes	7	8
327	1x43	1x47	ccr5_on	0	8.04	No	No	No	Yes	7	6
328	1x54	2x51	ccr5_on	0	4.28	No	No	No	No	7	7
329	1x56	8x54	ccr5_on	0	4.28	No	No	No	No	7	6
330	1x57	2x44	ccr5_on	0	6.23	No	No	No	No	7	6
331	1x58	I1x49	ccr5_on	0	4.385	No	No	No	No	3	5
332	1x59	8x57	ccr5_on	0	6.04	No	No	No	No	4	4
333	I1x48	I1x51	ccr5_on	0	4.31	No	No	No	No	5	7
334	I1x49	I1x50	ccr5_on	0	6.075	No	No	No	No	5	6
335	2x37	I2x57	ccr5_on	0	7.905	No	No	Yes	Yes	7	6
336	2x39	I2x57	ccr5_on	0	3.88	No	No	Yes	Yes	8	6
337	2x42	3x49	ccr5_on	0	4.6	Yes	Yes	No	Yes	7	8
338	2x46	2x50	ccr5_on	0	4.75	No	No	No	Yes	9	9
339	2x50	7x46	ccr5_on	0	5.45	No	Yes	No	No	9	8
340	2x52	3x31	ccr5_on	0	6.7	No	No	No	No	7	5
341	2x53	3x36	ccr5_on	0	4.29	No	Yes	No	Yes	7	7
342	2x56	3x32	ccr5_on	0	4.995	No	No	Yes	Yes	7	7
343	2x57	7x42	ccr5_on	0	6.85	No	No	No	Yes	7	8
344	2x60	2x63	ccr5_on	0	5.785	Yes	No	Yes	Yes	7	4
345	2x60	3x28	ccr5_on	0	7.975	Yes	No	No	No	7	5
346	E1x50	E2.S169	ccr5_on	0	4.94	Yes	Yes	No	No	9	4
347	3x24	E1x52	ccr5_on	0	4.975	No	No	No	Yes	6	7
348	3x37	5x42	ccr5_on	0	8.065	Yes	Yes	No	No	7	3
349	3x38	3x42	ccr5_on	0	5.285	No	No	Yes	Yes	7	7
350	3x41	5x46	ccr5_on	0	6.09	Yes	Yes	No	No	5	4
351	3x43	7x53	ccr5_on	0	6.65	No	No	Yes	Yes	8	9
352	3x46	7x53	ccr5_on	0	4.105	No	No	Yes	Yes	9	9
353	3x47	5x54	ccr5_on	0	4.515	No	No	No	No	9	8
354	3x47	5x58	ccr5_on	0	6.24	No	No	Yes	Yes	9	9
355	3x50	5x58	ccr5_on	0	7.2	No	No	Yes	Yes	9	9
356	3x50	7x53	ccr5_on	0	4.63	No	No	Yes	Yes	9	9
357	4x41	4x45	ccr5_on	0	7.78	No	No	No	No	3	6
358	4x64	E2.P183	ccr5_on	0	8.665	Yes	Yes	No	No	5	3
359	4x65	E2x52	ccr5_on	0	5.6	No	No	No	No	5	4
360	E2.Q170	E2.R168	ccr5_on	0	5.26	No	No	No	No	1	4
361	E2.H181	E2.R168	ccr5_on	0	13.545	No	No	No	No	4	4
362	E2.H181	Lig	ccr5_on	0	7.8	No	No	Yes	Yes	4	0
363	5x32	E2.F182	ccr5_on	0	7.735	No	No	Yes	Yes	3	5
364	5x35	E2.F182	ccr5_on	0	5.01	Yes	Yes	Yes	Yes	3	5
365	5x33	5x36	ccr5_on	0	4.07	No	No	No	No	2	4
366	5x36	6x59	ccr5_on	0	6.005	No	No	No	Yes	4	5
367	5x37	6x59	ccr5_on	0	4.385	No	No	No	Yes	3	5
368	5x39	Lig	ccr5_on	0	5.725	Yes	No	Yes	Yes	5	0
369	5x43	6x55	ccr5_on	0	4.995	No	No	No	Yes	5	6
370	5x50	6x44	ccr5_on	0	7.645	Yes	No	Yes	Yes	9	9
371	5x54	6x44	ccr5_on	0	4.19	No	No	Yes	Yes	8	9
372	5x58	6x40	ccr5_on	0	4.23	Yes	Yes	No	No	9	8
373	5x58	6x41	ccr5_on	0	5.985	Yes	Yes	Yes	No	9	8
374	5x62	6x34	ccr5_on	0	5.215	No	No	No	No	4	6
375	5x62	6x37	ccr5_on	0	7.14	No	No	No	No	4	8
376	6x26	6x29	ccr5_on	0	9.79	No	No	No	No	0	6
377	6x27	6x30	ccr5_on	0	7.56	No	No	No	No	3	7
378	6x36	7x56	ccr5_on	0	7.45	No	No	No	No	8	7
379	6x45	6x49	ccr5_on	0	6.935	Yes	No	No	No	5	6
380	6x47	7x43	ccr5_on	0	7.785	No	Yes	No	No	8	5
381	6x54	7x34	ccr5_on	0	6.845	No	No	No	Yes	5	5
382	6x55	7x34	ccr5_on	0	4.945	No	Yes	No	Yes	6	5
383	6x57	7x30	ccr5_on	0	5.54	No	No	No	No	4	5
384	6x58	Lig	ccr5_on	0	6.715	No	No	Yes	Yes	4	0
385	6x60	6x63	ccr5_on	0	6.965	No	No	No	No	5	1
386	6x61	E3.L266	ccr5_on	0	3.99	No	No	No	No	4	4
387	6x61	7x30	ccr5_on	0	5.32	No	No	No	No	4	5
388	7x49	7x50	ccr5_on	0	7.33	No	Yes	No	No	9	9
389	7x49	7x53	ccr5_on	0	5.81	No	Yes	Yes	Yes	9	9
390	7x52	7x53	ccr5_on	0	4.235	No	No	Yes	Yes	8	9
391	7x55	8x50	ccr5_on	0	5.895	No	No	Yes	Yes	7	8
392	8x49	8x53	ccr5_on	0	7.765	No	No	No	No	6	5
393	1x30	7x32	ccr5_on	0	4.115	No	No	No	No	2	1
394	3x32	7x38	ccr5_on	0	4.49	Yes	Yes	No	No	7	6
395	E2.E172	E2.H175	ccr5_on	0	8.615	No	No	No	No	2	1
396	5x31	5x34	ccr5_on	0	4.685	No	No	No	No	3	1
397	6x26	6x28	ccr5_on	0	7.695	No	No	No	No	0	5
398	I2x52	I2x55	ccr5_on	0	3.72	No	No	No	No	5	3
399	1x38	7x39	ccr5_on	0	3.685	No	No	No	No	6	6
400	1x47	2x51	ccr5_on	0	3.655	No	Yes	No	No	6	7
401	6x36	6x40	ccr5_on	0	3.565	No	No	No	No	8	8
402	2x54	7x42	ccr5_on	0	3.535	No	No	No	Yes	6	8
403	3x34	3x35	ccr5_on	0	3.53	No	No	No	No	5	8
404	1x57	2x43	ccr5_on	0	3.46	No	No	No	No	7	8
405	1x42	7x47	ccr5_on	0	3.42	No	No	No	No	7	8
406	5x461	6x52	ccr5_on	0	3.395	No	No	No	No	6	8
407	3x47	5x57	ccr5_on	0	3.38	No	No	No	No	9	8
408	8x48	8x52	ccr5_on	0	3.285	No	No	No	No	5	5
409	6x34	6x38	ccr5_on	0	3.275	No	No	No	No	6	5
410	7x47	7x48	ccr5_on	0	3.275	No	No	Yes	No	8	6
411	3x52	I2x53	ccr5_on	0	3.155	No	No	No	No	5	5
412	1x30	1x33	ccr5_on	0	3.135	No	No	No	No	2	3
413	6x46	6x47	ccr5_on	0	3.045	No	No	No	Yes	5	8
414	1x33	1x34	ccr5_on	0	3.035	No	No	No	No	3	6
415	8x48	8x50	ccr5_on	0	2.915	No	No	Yes	Yes	5	8
416	5x59	5x60	ccr5_on	0	2.785	No	No	No	No	3	4
417	5x47	5x51	ccr5_on	0	2.77	No	No	No	No	8	6
418	Lig	NT.T16	ccr5_on	0	2.585	Yes	Yes	No	No	0	2
419	1x45	7x51	ccr5_on	0	2.51	No	No	No	No	5	6
420	1x34	1x37	ccr5_on	0	2.465	No	No	No	No	6	5
421	E2.E172	E2.G173	ccr5_on	0	2.455	No	No	No	No	2	1
422	1x52	7x55	ccr5_on	0	2.435	No	No	No	No	6	7
423	4x56	5x42	ccr5_on	0	2.41	No	No	No	No	5	3
424	5x65	6x33	ccr5_on	0	2.365	No	No	No	No	8	8
425	7x24	7x28	ccr5_on	0	2.36	No	No	No	No	6	1
426	5x51	6x44	ccr5_on	0	2.34	No	No	Yes	Yes	6	9
427	4x57	4x62	ccr5_on	0	2.325	No	No	No	No	7	4
428	1x32	Lig	ccr5_on	0	2.315	No	No	Yes	Yes	4	0
429	5x45	5x48	ccr5_on	0	2.305	No	No	No	No	5	4
430	E2.K171	E2.S169	ccr5_on	0	2.295	No	No	No	No	2	4
431	5x55	6x41	ccr5_on	0	2.28	No	No	Yes	No	4	8
432	2x66	E1x49	ccr5_on	0	2.275	No	No	No	No	4	3
433	4x59	4x62	ccr5_on	0	2.14	No	No	No	No	4	4
434	5x45	5x46	ccr5_on	0	2.14	No	No	No	No	5	4
435	5x61	5x65	ccr5_on	0	2.14	Yes	No	No	No	8	8
436	6x32	6x35	ccr5_on	0	2.13	No	No	No	No	7	5
437	5x68	6x30	ccr5_on	0	2.09	No	No	No	No	0	7
438	5x49	5x52	ccr5_on	0	2.075	No	No	No	No	6	4
439	1x26	1x29	ccr5_on	0	1.98	No	No	No	No	1	2
440	3x21	E2.K171	ccr5_on	0	1.745	No	No	No	No	8	2
441	1x49	1x52	ccr5_on	0	1.71	No	No	No	No	8	6
442	2x41	4x43	ccr5_on	0	1.54	No	No	No	No	7	4
443	4x44	4x48	ccr5_on	0	1.535	No	No	No	No	1	3
444	8x47	8x51	ccr5_on	0	1.5	No	No	No	No	8	8
445	6x53	6x57	ccr5_on	0	1.425	No	No	No	No	6	4
446	E2.L174	Lig	ccr5_on	0	1.33	No	No	Yes	Yes	4	0
447	4x54	4x55	ccr5_on	0	1.31	No	No	No	No	4	4
448	5x64	5x67	ccr5_on	0	1.295	No	No	No	No	5	5
449	6x35	6x39	ccr5_on	0	1.29	No	No	No	No	5	5
450	8x57	CT.K314	ccr5_on	0	1.24	No	No	No	No	4	6
451	6x27	6x31	ccr5_on	0	1.23	No	No	No	No	3	5
452	4x46	4x47	ccr5_on	0	0.81	No	No	No	No	7	4
453	5x68	6x29	ccr5_on	0	0.81	No	No	No	No	0	6
454	6x39	6x43	ccr5_on	0	0.795	No	No	No	No	5	6
455	7x36	7x37	ccr5_on	0	0.795	No	No	No	Yes	5	7
456	1x40	1x44	ccr5_on	0	0.775	No	No	No	No	3	5
457	8x55	8x56	ccr5_on	0	0.745	No	No	No	No	4	4
458	8x52	8x55	ccr5_on	0	0.685	No	No	No	No	5	4
459	6x30	6x34	ccr5_on	0	0.655	No	No	No	No	7	6

Orange: nodes, hubs and links specific of ccr5_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccr5_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	ccr5_off Avg Int. Strength	ccr5_on Avg Int. Strength	ccr5_off Num Of Links	ccr5_on Num Of Links	ConSurf
1	1x60	ccr5_off	4.6725	3.7475	4	2	5
2	2x60	ccr5_off	11.014	12.1733	5	3	7
3	3x22	ccr5_off	7.8525	6.0975	4	2	3
4	3x40	ccr5_off	8.1325	4.235	4	1	7
5	3x44	ccr5_off	4.2625	4.49333	4	3	7
6	3x51	ccr5_off	7.85	6.95667	5	3	8
7	4x50	ccr5_off	8.1175	7.68167	4	3	9
8	E2.T177	ccr5_off	8.255	4.3075	4	2	2
9	5x39	ccr5_off	7.3425	5.725	4	1	5
10	5x50	ccr5_off	4.588	5.61833	5	3	9
11	5x61	ccr5_off	3.955	5.25167	4	3	8
12	6x41	ccr5_off	5.2225	4.1325	4	2	8
13	6x45	ccr5_off	6.134	4.685	5	2	5
14	6x51	ccr5_off	7.5475	12.6783	4	3	7
15	E3.N267	ccr5_off	6.495	2.0075	4	2	3
16	7x45	ccr5_off	6.258	10.315	5	3	9
17	7x48	ccr5_off	4.94	3.4775	4	2	6
18	Lig	Shared	40.7261	31.3662	33	34	0
19	1x39	Shared	7.495	6.9425	6	4	8
20	2x42	Shared	8.59	7.189	4	5	7
21	2x63	Shared	6.446	6.735	5	4	4
22	E1x50	Shared	9.20833	10.386	6	5	9
23	3x32	Shared	9.5675	7.912	4	5	7
24	3x37	Shared	5.60167	6.30375	6	4	7
25	3x41	Shared	3.72	3.578	4	5	5
26	3x42	Shared	8.8475	9.07	4	4	7
27	I2x57	Shared	7.245	6.461	4	5	6
28	4x64	Shared	8.8225	8.75	4	4	5
29	E2.F182	Shared	7.665	5.8625	4	4	5
30	5x35	Shared	10.314	9.361	5	5	3
31	5x58	Shared	5.595	6.15917	4	6	9
32	6x44	Shared	10.2275	6.15667	4	6	9
33	6x48	Shared	9.77	9.88125	5	4	9
34	7x53	Shared	4.935	5.086	4	5	9
35	8x50	Shared	4.602	6.059	5	5	8
36	1x24	ccr5_on	11.83	5.30125	3	4	3
37	1x47	ccr5_on	4.34	4.6275	2	4	6
38	2x50	ccr5_on	9.425	6.92625	2	4	9
39	2x53	ccr5_on	6.96333	8.26	3	4	7
40	E1x52	ccr5_on	10.91	8.44375	3	4	7
41	3x36	ccr5_on	7.81333	5.81875	3	4	7
42	3x49	ccr5_on	10.01	8.1125	3	4	8
43	6x47	ccr5_on	8.36667	6.48125	3	4	8
44	6x55	ccr5_on	6.86	7.73875	3	4	6
45	6x59	ccr5_on	12.9	7.68375	2	4	5
46	7x34	ccr5_on	6.745	5.45875	2	4	5
47	7x37	ccr5_on	4.94667	4.44875	3	4	7
48	7x42	ccr5_on	8	5.578	3	5	8
49	7x49	ccr5_on	5.31667	7.02875	3	4	9

Orange: nodes, hubs and links specific of ccr5_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccr5_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ccr5_off Recurrence	ccr5_on Recurrence	ccr5_off Hub1?	ccr5_on Hub1?	ccr5_off Hub2?	ccr5_on Hub2?	ConSurf1	ConSurf2
1	7x35	7x39	ccr5_off	11.1489	0	No	No	No	No	3	6
2	1x39	7x42	ccr5_off	10.2208	7.44616	Yes	Yes	No	Yes	8	8
3	2x60	Lig	ccr5_off	23.1006	5.07311	Yes	No	Yes	Yes	7	0
4	2x54	7x46	ccr5_off	10.7691	0	No	No	No	No	6	8
5	1x50	2x50	ccr5_off	13.1271	2.56925	No	No	No	Yes	9	9
6	7x45	7x49	ccr5_off	17.9329	0	Yes	No	No	Yes	9	9
7	6x48	7x45	ccr5_off	33.4898	9.44084	Yes	Yes	Yes	No	9	9
8	6x48	6x51	ccr5_off	100	0	Yes	Yes	Yes	No	9	7
9	6x51	6x55	ccr5_off	49.7886	3.79782	Yes	No	No	Yes	7	6
10	6x51	7x38	ccr5_off	53.5694	2.46648	Yes	No	No	No	7	6
11	7x38	Lig	ccr5_off	48.0863	0	No	No	Yes	Yes	6	0
12	7x53	8x50	ccr5_off	26.2794	0	Yes	Yes	Yes	Yes	9	8
13	6x40	7x53	ccr5_off	33.4612	0	No	No	Yes	Yes	8	9
14	3x43	6x40	ccr5_off	34.9842	0	No	No	No	No	8	8
15	3x40	3x43	ccr5_off	34.2711	0	Yes	No	No	No	7	8
16	3x40	6x44	ccr5_off	45.1369	1.88723	Yes	No	Yes	Yes	7	9
17	2x52	4x50	ccr5_off	14.3922	0	No	No	Yes	No	7	9
18	3x42	4x50	ccr5_off	19.4775	1.3547	Yes	Yes	Yes	No	7	9
19	1x56	8x50	ccr5_off	20.3878	2.83552	No	No	Yes	Yes	7	8
20	1x56	8x53	ccr5_off	18.8181	0	No	No	No	No	7	5
21	1x60	8x53	ccr5_off	11.0414	7.44616	Yes	No	No	No	5	5
22	2x38	2x42	ccr5_off	15.1806	1.39674	No	No	Yes	Yes	6	7
23	2x38	I2x57	ccr5_off	11.9194	0	No	No	Yes	Yes	6	6
24	E1x50	E1x52	ccr5_off	17.0979	5.42346	Yes	Yes	No	Yes	9	7
25	2x60	E1x50	ccr5_off	23.8855	0	Yes	No	Yes	Yes	7	9
26	3x25	E1x50	ccr5_off	19.2051	1.79848	No	No	Yes	Yes	9	9
27	3x22	E2.S169	ccr5_off	20.5096	0	Yes	No	No	No	3	4
28	3x25	E2.S169	ccr5_off	23.9034	0	No	No	No	No	9	4
29	3x22	3x26	ccr5_off	10.2853	3.55491	Yes	No	No	No	3	7
30	6x44	6x45	ccr5_off	42.9652	0	Yes	Yes	Yes	No	9	5
31	3x51	5x61	ccr5_off	13.0985	0	Yes	No	Yes	No	8	8
32	5x54	5x58	ccr5_off	34.7405	0	No	No	Yes	Yes	8	9
33	5x54	6x45	ccr5_off	33.8267	0	No	No	Yes	No	8	5
34	4x64	E2.F182	ccr5_off	10.7261	5.36273	Yes	Yes	Yes	Yes	5	5
35	7x48	7x52	ccr5_off	12.7258	0	Yes	No	No	No	6	8
36	7x45	7x48	ccr5_off	17.4599	0	Yes	No	Yes	No	9	6
37	7x30	E3.L266	ccr5_off	24.0503	0	No	No	No	No	5	4
38	6x58	7x30	ccr5_off	27.0248	8.13285	No	No	No	No	4	5
39	6x58	6x61	ccr5_off	15.0516	0	No	No	No	No	4	4
40	6x58	7x34	ccr5_off	14.9441	1.63031	No	No	No	Yes	4	5
41	7x34	Lig	ccr5_off	16.288	4.2089	No	Yes	Yes	Yes	5	0
42	7x26	E3.L266	ccr5_off	12.0807	7.09581	No	No	No	No	1	4
43	2x53	7x46	Shared	12.5394	34.769	No	Yes	No	No	7	8
44	2x53	3x32	Shared	16.5388	83.725	No	Yes	Yes	Yes	7	7
45	3x32	Lig	Shared	28.6984	100	Yes	Yes	Yes	Yes	7	0
46	2x50	7x49	Shared	14.7362	29.4997	No	Yes	No	Yes	9	9
47	6x55	Lig	Shared	48.0612	30.9852	No	Yes	Yes	Yes	6	0
48	6x44	6x48	Shared	83.5257	80.6138	Yes	Yes	Yes	Yes	9	9
49	2x44	2x48	Shared	12.2563	26.7389	No	No	No	No	6	6
50	2x48	2x52	Shared	13.3278	28.0703	No	No	No	No	6	7
51	3x42	4x49	Shared	22.5738	24.3799	Yes	Yes	No	No	7	6
52	3x41	4x49	Shared	43.4633	43.3596	Yes	Yes	No	No	5	6
53	3x37	3x41	Shared	46.746	53.0714	Yes	Yes	Yes	Yes	7	5
54	3x33	3x37	Shared	40.1914	29.0279	No	No	Yes	Yes	5	7
55	3x32	3x33	Shared	36.7833	29.794	Yes	Yes	No	No	7	5
56	2x42	3x45	Shared	22.3552	19.0685	Yes	Yes	No	No	7	6
57	3x45	4x49	Shared	23.3515	20.3718	No	No	No	No	6	6
58	2x63	E1x50	Shared	17.1552	17.555	Yes	Yes	Yes	Yes	4	9
59	2x63	Lig	Shared	31.0063	18.9144	Yes	Yes	Yes	Yes	4	0
60	3x36	3x37	Shared	29.279	28.2665	No	Yes	Yes	Yes	7	7
61	3x36	6x48	Shared	31.1353	92.6379	No	Yes	Yes	Yes	7	9
62	5x58	5x61	Shared	25.7418	15.8032	Yes	Yes	Yes	No	9	8
63	E2.F182	Lig	Shared	13.3493	15.5463	Yes	Yes	Yes	Yes	5	0
64	6x61	Lig	Shared	16.2486	17.0365	No	No	Yes	Yes	4	0
65	1x24	Lig	ccr5_on	4.4904	27.435	No	Yes	Yes	Yes	3	0
66	1x24	1x27	ccr5_on	3.14292	21.0165	No	Yes	No	No	3	1
67	1x27	7x32	ccr5_on	1.57325	19.3161	No	No	No	No	1	1
68	1x30	7x32	ccr5_on	0	17.6064	No	No	No	No	2	1
69	2x53	7x42	ccr5_on	4.35421	53.7394	No	Yes	No	Yes	7	8
70	1x30	1x33	ccr5_on	0	10.6741	No	No	No	No	2	3
71	1x42	7x42	ccr5_on	0	33.3115	No	No	No	Yes	7	8
72	1x43	2x58	ccr5_on	1.66643	10.2023	No	No	No	No	7	9
73	2x57	2x58	ccr5_on	3.32927	11.6457	No	No	No	No	7	9
74	2x57	7x42	ccr5_on	0	13.0798	No	No	No	Yes	7	8
75	2x50	7x46	ccr5_on	0	33.774	No	Yes	No	No	9	8
76	7x55	8x50	ccr5_on	0	17.3168	No	No	Yes	Yes	7	8
77	7x51	7x55	ccr5_on	1.66284	22.6888	No	No	No	No	6	7
78	7x48	7x51	ccr5_on	3.3221	29.4016	Yes	No	No	No	6	6
79	7x47	7x48	ccr5_on	0	30.7143	No	No	Yes	No	8	6
80	1x42	7x47	ccr5_on	0	32.0176	No	No	No	No	7	8
81	2x52	3x31	ccr5_on	0	29.3923	No	No	No	No	7	5
82	2x56	3x31	ccr5_on	1.45499	30.7049	No	No	No	No	7	5
83	2x56	3x32	ccr5_on	0	32.0082	No	No	Yes	Yes	7	7
84	1x58	I1x49	ccr5_on	0	15.7519	No	No	No	No	3	5
85	I1x49	I1x50	ccr5_on	0	17.1579	No	No	No	No	5	6
86	2x44	I1x50	ccr5_on	4.5549	22.6888	No	No	No	No	6	6
87	1x58	1x59	ccr5_on	3.42603	14.3364	No	No	No	No	3	4
88	1x59	8x57	ccr5_on	0	11.4682	No	No	No	No	4	4
89	2x49	3x38	ccr5_on	2.28283	16.7562	No	No	No	No	8	7
90	3x38	3x42	ccr5_on	0	17.8493	No	No	Yes	Yes	7	7
91	2x53	3x36	ccr5_on	0	61.1622	No	Yes	No	Yes	7	7
92	3x36	5x43	ccr5_on	9.86597	34.5915	No	Yes	No	No	7	5
93	5x43	6x55	ccr5_on	0	34.3346	No	No	No	Yes	5	6
94	E2.E172	Lig	ccr5_on	1.33673	10.4545	No	No	Yes	Yes	2	0
95	3x34	3x35	ccr5_on	0	12.6921	No	No	No	No	5	8
96	2x49	3x35	ccr5_on	0.00358372	14.0561	No	No	No	No	8	8
97	7x49	7x53	ccr5_on	0	28.1216	No	Yes	Yes	Yes	9	9
98	5x50	6x44	ccr5_on	0	13.0425	Yes	No	Yes	Yes	9	9
99	3x47	5x54	ccr5_on	0	57.5419	No	No	No	No	9	8
100	5x54	6x44	ccr5_on	0	58.7238	No	No	Yes	Yes	8	9
101	3x47	5x58	ccr5_on	0	41.3042	No	No	Yes	Yes	9	9
102	3x51	5x57	ccr5_on	1.65926	16.6441	Yes	No	No	No	8	8
103	3x47	5x57	ccr5_on	0	18.4472	No	No	No	No	9	8
104	3x50	5x58	ccr5_on	0	21.3949	No	No	Yes	Yes	9	9
105	3x50	7x53	ccr5_on	0	21.8573	No	No	Yes	Yes	9	9
106	5x51	6x44	ccr5_on	0	14.869	No	No	Yes	Yes	6	9
107	5x58	6x37	ccr5_on	3.13217	28.7196	Yes	Yes	No	No	9	8
108	5x62	6x37	ccr5_on	0	26.155	No	No	No	No	4	8
109	5x62	6x34	ccr5_on	0	23.5811	No	No	No	No	4	6
110	5x68	6x30	ccr5_on	0	10.5713	No	No	No	No	0	7
111	6x30	6x34	ccr5_on	0	18.4052	No	No	No	No	7	6
112	6x57	7x30	ccr5_on	0	11.2627	No	No	No	No	4	5
113	8x48	8x50	ccr5_on	0	10.3611	No	No	Yes	Yes	5	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
E2x52	Lig	Shared	16.77	3.93	1	1	1	0
E2.F182	Lig	Shared	7.13	4.81	1	1	1	0
5x40	Lig	Shared	7.88	3.94	1	1	1	0
6x55	Lig	Shared	4.44	5.19	1	1	1	0
2x60	Lig	Shared	28.37	22.76	1	1	1	0
3x29	Lig	Shared	8.74	7.785	1	1	1	0
4x65	Lig	ccr5_off	6.99	0	1	0	1	0
3x32	Lig	Shared	13.91	8.93	1	1	1	0
7x38	Lig	ccr5_off	7.37	0	1	0	1	0
2x63	Lig	Shared	7.03	7.62	1	1	1	0
7x35	Lig	Shared	17.85	7.825	1	1	1	0
E2x51	Lig	Shared	18.05	9.4	1	0	1	0
1x24	Lig	Shared	8.85	5.41	1	1	1	0
7x31	Lig	Shared	11.22	8.03	1	0	1	0
7x34	Lig	Shared	7.88	5.135	1	1	1	0
1x28	Lig	Shared	4.23	12.945	0	1	1	0
1x31	Lig	ccr5_off	4.73	0	0	0	1	0
E2.E172	Lig	Shared	22.59	25.895	1	1	1	0
E2.T177	Lig	Shared	4.25	4.245	1	1	1	0
Lig	NT.P19	Shared	22.31	13.22	1	1	0	1
Lig	NT.C20	ccr5_off	4.19	0	1	1	0	1
6x61	Lig	Shared	11.28	5.05	1	1	1	0
E3.N267	Lig	Shared	7.17	2.7	1	1	1	0
7x27	Lig	Shared	5.28	3.96	0	0	1	0
Lig	NT.S17	Shared	11.04	3.26	1	1	0	1
E2.K171	Lig	ccr5_off	10.8	0	1	0	1	0
E2.G173	Lig	ccr5_off	5.12	0	1	0	1	0
E2.Q170	Lig	Shared	5.86	9.04	1	1	1	0
E2.Y184	Lig	Shared	22.88	20.515	1	0	1	0
5x32	Lig	Shared	23.77	20.085	1	1	1	0
7x24	NT.C20	Shared	7.28	7.28	0	0	2	1
7x28	NT.C20	ccr5_off	4.72	0	0	0	2	1
1x24	1x27	Shared	19.73	3.795	1	1	1	2
1x24	7x31	ccr5_off	6.91	0	1	1	1	1
2x53	3x32	Shared	10.32	15.475	0	0	2	1
2x53	7x42	Shared	4.98	5.595	0	0	2	2
2x56	2x60	ccr5_off	9.7	0	0	0	2	1
2x60	E1x50	ccr5_off	6.56	0	1	1	1	2
2x60	3x32	ccr5_off	5.79	0	1	1	1	1
2x60	7x42	ccr5_off	4.65	0	1	1	1	2
2x63	E1x50	Shared	9.65	9.165	1	1	1	2
2x63	E2.H175	ccr5_off	6.53	0	1	1	1	2
2x63	E2.T177	Shared	4.99	4.37	1	1	1	1
2x63	E2x50	ccr5_off	4.03	0	1	1	1	2
E1x50	E2x50	Shared	16.98	11.1	1	1	2	2
3x29	4x65	Shared	14.13	8.635	1	1	1	1
3x32	3x33	Shared	8.25	5.67	1	1	1	2
3x33	4x61	Shared	19.33	11.775	0	0	2	2
4x60	5x39	ccr5_off	6.32	0	0	0	2	1
4x61	5x39	ccr5_off	9.24	0	6	0	2	1
4x61	5x42	ccr5_off	5.6	0	6	0	2	2
4x64	E2.F182	Shared	10.72	5.895	0	1	2	1
4x64	5x35	Shared	15.03	13.53	0	1	2	2
4x64	5x39	ccr5_off	7.03	0	0	1	2	1
E2.E172	E2.Q170	ccr5_off	12.74	0	1	1	1	1
E2.H181	E2.Q170	Shared	11.13	11.745	0	1	1	1
E2.K171	E2.Y176	Shared	17.91	7.765	1	0	1	2
E2.E172	E2.T177	ccr5_off	16.93	0	1	1	1	1
E2.H175	E2.T177	ccr5_off	6.85	0	1	0	2	1
E2.H181	E2x51	ccr5_off	5.58	0	0	1	1	1
E2.F182	E2x52	ccr5_off	6.61	0	1	1	1	1
5x36	E2.F182	ccr5_off	6.2	0	0	0	2	1
E2.S185	E2.Y184	ccr5_off	6.36	0	0	0	2	1
5x32	5x36	Shared	8.36	6.57	1	1	1	2
5x39	5x42	ccr5_off	6.78	0	6	0	1	2
5x40	6x55	ccr5_off	4.42	0	1	1	1	1
5x40	6x59	Shared	14.13	12.56	1	1	1	2
6x51	6x55	Shared	11.72	15.825	0	0	2	1
6x51	7x38	Shared	6.73	13.47	0	0	2	1
6x58	6x61	ccr5_off	6.6	0	0	1	1	1
6x58	7x30	Shared	5.49	6.18	0	1	1	2
6x58	7x34	Shared	5.61	4.91	0	1	1	1
6x61	E3.N267	ccr5_off	3.96	0	1	1	1	1
6x62	E3.N267	Shared	13.15	1.315	0	0	2	1
7x30	E3.L266	ccr5_off	5.54	0	0	0	2	2
7x35	7x38	ccr5_off	11.47	0	1	1	1	1
7x35	7x39	ccr5_off	5.67	0	1	1	1	2
3x21	E1x50	ccr5_off	2.81	0	0	0	2	2
E2.G173	E2.L174	ccr5_off	1.71	0	1	0	1	1
6x65	E3.N267	ccr5_off	1.7	0	0	0	2	1
NT.S17	NT.T16	ccr5_off	1.6	0	1	0	1	1
NT.E18	NT.P19	Shared	1.57	3.93	0	1	1	1
Lig	NT.Q21	Shared	1.44	6.89	1	1	0	1
1x25	NT.Q21	ccr5_off	1.37	0	0	0	2	1
Lig	NT.E18	ccr5_on	0	7.09	1	1	0	1
1x24	1x28	ccr5_on	0	4.31	1	1	1	1
1x24	7x28	ccr5_on	0	7.69	1	1	1	2
1x31	7x35	ccr5_on	0	4.55	0	0	1	1
2x56	3x32	ccr5_on	0	4.995	0	0	2	1
2x60	2x63	ccr5_on	0	5.785	1	1	1	1
2x60	3x28	ccr5_on	0	7.975	1	1	1	2
E1x50	E2.S169	ccr5_on	0	4.94	1	1	2	2
4x65	E2x52	ccr5_on	0	5.6	1	0	1	1
E2.Q170	E2.R168	ccr5_on	0	5.26	1	1	1	2
E2.H181	E2.R168	ccr5_on	0	13.545	0	1	1	2
E2.H181	Lig	ccr5_on	0	7.8	0	1	1	0
5x32	E2.F182	ccr5_on	0	7.735	1	1	1	1
5x35	E2.F182	ccr5_on	0	5.01	8	1	2	1
5x36	6x59	ccr5_on	0	6.005	0	0	2	2
5x39	Lig	ccr5_on	0	5.725	6	0	1	0
5x43	6x55	ccr5_on	0	4.995	0	0	2	1
6x54	7x34	ccr5_on	0	6.845	0	0	2	1
6x55	7x34	ccr5_on	0	4.945	1	1	1	1
6x58	Lig	ccr5_on	0	6.715	0	1	1	0
6x61	E3.L266	ccr5_on	0	3.99	1	1	1	2
6x61	7x30	ccr5_on	0	5.32	1	1	1	2
3x32	7x38	ccr5_on	0	4.49	1	1	1	1
E2.E172	E2.H175	ccr5_on	0	8.615	1	1	1	2
Lig	NT.T16	ccr5_on	0	2.585	1	1	0	1
E2.E172	E2.G173	ccr5_on	0	2.455	1	1	1	1
7x24	7x28	ccr5_on	0	2.36	0	0	2	2
1x32	Lig	ccr5_on	0	2.315	0	0	1	0
E2.K171	E2.S169	ccr5_on	0	2.295	1	0	1	2
3x21	E2.K171	ccr5_on	0	1.745	0	0	2	1
E2.L174	Lig	ccr5_on	0	1.33	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	ccr5_off	5UIW-CCR5-5P7-CCL5
	ccr5_on	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2

Network Difference
Value	ccr5_off	ccr5_on
I_min	3.89	3.86
Number of Linked Nodes	283	291
Number of Specific Nodes	5 (1.77%)	13 (4.47%)
Number of Shared Nodes	278 (98.23%)	278 (95.53%)
Number of Links	320	321
Number of Specific Links	138 (43.13%)	139 (43.30%)
Number of Shared Links	182 (56.88%)	182 (56.70%)
Number of Hubs	35	32
Number of Specific Hubs	17 (48.57%)	14 (43.75%)
Number of Shared Hubs	18 (51.43%)	18 (56.25%)
Average % Shared Neighbours (Jaccard)	42.03
Average % Shared Neighbours (Otsuka)	52.34
Average % Shared Neighbours (Overlap Coefficient)	62.47
Average % Shared Cliques (k3-6)	77.38
Graphlets Similarity	0.576379

Paths Difference
Value	ccr5_off	ccr5_on
Number Of Nodes in MetaPath	63	70
Specific Nodes in MetaPath	30 (47.62%)	37 (52.86%)
Shared Nodes in MetaPath	278 (98.23%)	278 (98.23%)
Number Of Links MetaPath	64	71
Specific Links in MetaPath	42 (65.63%)	49 (69.01%)
Shared Links in MetaPath	182 (56.88%)	182 (56.88%)
Number of Shortest Paths	64168	54529
Length Of Smallest Path	3	3
Average Path Length	11.6651	12.0437
Length of Longest Path	28	30
Minimum Path Strength	1.405	0.675
Average Path Strength	7.41246	6.35337
Maximum Path Strength	20.6133	19.09
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.941866	0.937417
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.7619	4.54545
Average % Of Corr. Nodes	59.2819	57.8784
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	45.3969	42.9826
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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