psnGPCR

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Orange: nodes, hubs and links specific of ccr8_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccr8_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ccr8_off Int. Strength	ccr8_on Int. Strength	ccr8_off Hub1?	ccr8_on Hub1?	ccr8_off Hub2?	ccr8_on Hub2?	ConSurf1	ConSurf2
1	E1x49	Lig	ccr8_off	3.96	0	Yes	No	Yes	Yes	5	0
2	E2.L181	Lig	ccr8_off	5.52	0	No	No	Yes	Yes	4	0
3	E2.S176	Lig	ccr8_off	6.26	0	No	No	Yes	Yes	3	0
4	E2.E177	Lig	ccr8_off	9.81	0	No	No	Yes	Yes	1	0
5	E2.Q173	Lig	ccr8_off	19.8	0	No	No	Yes	Yes	4	0
6	3x22	Lig	ccr8_off	10.12	0	No	No	Yes	Yes	4	0
7	E2.N188	Lig	ccr8_off	8.39	0	No	No	Yes	Yes	5	0
8	5x31	Lig	ccr8_off	7.89	0	No	No	Yes	Yes	4	0
9	E2.Q189	Lig	ccr8_off	11.09	0	No	No	Yes	Yes	3	0
10	1x35	1x39	ccr8_off	15.24	0	No	No	Yes	Yes	5	7
11	1x38	1x42	ccr8_off	6.09	0	No	No	No	No	5	6
12	1x39	7x38	ccr8_off	4.49	0	Yes	Yes	No	No	7	5
13	1x42	2x57	ccr8_off	3.65	0	No	No	Yes	Yes	6	7
14	1x43	2x54	ccr8_off	3.93	0	Yes	No	Yes	No	6	5
15	1x46	7x46	ccr8_off	5.16	0	No	No	Yes	No	8	8
16	1x47	2x54	ccr8_off	4.47	0	No	No	Yes	No	6	5
17	1x49	7x50	ccr8_off	4.06	0	No	No	No	No	7	9
18	1x50	2x51	ccr8_off	5.49	0	Yes	No	No	No	9	7
19	1x56	8x53	ccr8_off	4.15	0	No	No	Yes	No	7	5
20	1x57	8x50	ccr8_off	3.65	0	No	No	Yes	Yes	6	8
21	8x49	I1x48	ccr8_off	7.18	0	No	No	No	No	6	6
22	2x38	I2x57	ccr8_off	3.76	0	No	No	Yes	Yes	6	7
23	2x43	7x53	ccr8_off	8.21	0	No	No	Yes	Yes	8	9
24	2x45	4x50	ccr8_off	5.65	0	No	No	Yes	No	9	9
25	2x49	4x50	ccr8_off	6.18	0	No	No	Yes	No	8	9
26	2x53	6x48	ccr8_off	4.01	0	Yes	Yes	Yes	Yes	6	8
27	2x60	2x63	ccr8_off	4.51	0	No	No	No	No	5	5
28	E1x49	E2.V180	ccr8_off	4.3	0	Yes	No	No	No	5	4
29	3x25	E1x50	ccr8_off	3.92	0	No	No	Yes	Yes	9	8
30	3x32	7x42	ccr8_off	5.16	0	Yes	No	Yes	Yes	6	7
31	3x33	5x43	ccr8_off	3.59	0	Yes	Yes	No	No	3	4
32	3x40	5x50	ccr8_off	6.71	0	No	No	Yes	No	7	9
33	3x43	5x54	ccr8_off	5.02	0	No	No	Yes	Yes	8	7
34	3x43	6x40	ccr8_off	4.61	0	No	No	No	No	8	7
35	3x44	5x54	ccr8_off	3.89	0	No	No	Yes	Yes	7	7
36	3x45	4x49	ccr8_off	4.47	0	No	No	No	No	5	6
37	3x50	6x34	ccr8_off	7.52	0	No	No	No	No	9	6
38	3x50	6x37	ccr8_off	5.23	0	No	No	No	No	9	7
39	3x51	5x56	ccr8_off	7.22	0	Yes	Yes	No	No	8	4
40	3x51	5x61	ccr8_off	4.84	0	Yes	Yes	No	No	8	8
41	3x55	3x56	ccr8_off	5.54	0	No	No	No	No	7	5
42	4x57	4x62	ccr8_off	4.42	0	No	No	No	No	6	4
43	4x64	E2.Y187	ccr8_off	17.54	0	No	No	Yes	No	5	5
44	4x65	E2x52	ccr8_off	7.63	0	No	No	No	No	4	4
45	E2.F186	E2.Q173	ccr8_off	7.03	0	No	Yes	No	No	5	4
46	E2.Y187	E2x52	ccr8_off	6.36	0	Yes	No	No	No	5	4
47	5x32	E2.Y187	ccr8_off	3.75	0	No	No	Yes	No	3	5
48	5x36	E2.Y187	ccr8_off	14.33	0	No	Yes	Yes	No	3	5
49	5x31	E2.Q189	ccr8_off	5.12	0	No	No	No	No	4	3
50	5x35	5x38	ccr8_off	4.01	0	No	Yes	No	No	2	3
51	5x40	6x55	ccr8_off	12.36	0	No	Yes	No	No	4	5
52	5x41	5x45	ccr8_off	3.77	0	No	No	No	No	4	4
53	5x43	6x55	ccr8_off	4.24	0	No	No	No	No	4	5
54	5x44	6x55	ccr8_off	4.12	0	No	No	No	No	5	5
55	5x54	6x45	ccr8_off	6.09	0	Yes	Yes	No	No	7	5
56	5x62	5x66	ccr8_off	4.23	0	No	No	No	No	5	5
57	5x63	5x67	ccr8_off	9.03	0	No	No	No	No	4	5
58	6x36	7x53	ccr8_off	5.86	0	No	No	Yes	Yes	7	9
59	6x40	7x53	ccr8_off	5.05	0	No	No	Yes	Yes	7	9
60	6x46	6x47	ccr8_off	6.09	0	No	No	No	Yes	5	7
61	6x50	7x37	ccr8_off	5.25	0	No	No	No	No	9	7
62	6x61	7x26	ccr8_off	10.61	0	No	No	No	No	1	2
63	7x26	7x29	ccr8_off	4.12	0	No	No	No	No	2	4
64	7x28	7x29	ccr8_off	16.64	0	No	No	No	No	4	4
65	7x53	8x50	ccr8_off	5.16	0	Yes	Yes	Yes	Yes	9	8
66	8x49	8x50	ccr8_off	11.17	0	No	No	Yes	Yes	6	8
67	8x52	8x53	ccr8_off	11.79	0	No	No	Yes	No	6	5
68	2x52	3x35	ccr8_off	3.42	0	No	No	No	No	7	8
69	7x28	7x32	ccr8_off	3.38	0	No	No	No	No	4	3
70	6x54	7x34	ccr8_off	3.17	0	No	No	No	No	4	4
71	1x36	2x64	ccr8_off	3.15	0	No	No	No	No	5	5
72	3x43	6x44	ccr8_off	3.1	0	No	No	No	No	8	9
73	3x32	6x51	ccr8_off	3.09	0	Yes	No	No	No	6	6
74	7x36	7x40	ccr8_off	3.07	0	No	No	No	No	5	7
75	7x48	7x52	ccr8_off	3.07	0	No	No	No	No	7	8
76	4x41	I2x56	ccr8_off	3.04	0	Yes	No	No	No	4	5
77	5x59	5x60	ccr8_off	2.91	0	No	No	No	No	5	3
78	6x38	6x42	ccr8_off	2.85	0	No	No	No	No	4	5
79	5x33	5x36	ccr8_off	2.82	0	No	No	No	Yes	1	3
80	5x57	5x58	ccr8_off	2.69	0	No	No	Yes	Yes	7	8
81	7x35	7x39	ccr8_off	2.65	0	No	No	No	No	4	4
82	5x37	5x41	ccr8_off	2.51	0	No	No	No	No	3	4
83	3x24	E1x52	ccr8_off	2.49	0	No	No	Yes	Yes	5	7
84	5x66	5x67	ccr8_off	2.48	0	No	No	No	No	5	5
85	5x58	6x38	ccr8_off	2.34	0	Yes	Yes	No	No	8	4
86	3x21	E2.V174	ccr8_off	1.84	0	No	No	No	No	7	4
87	7x46	7x47	ccr8_off	1.82	0	Yes	No	No	No	8	6
88	6x50	7x40	ccr8_off	1.69	0	No	No	No	No	9	7
89	7x43	7x47	ccr8_off	1.69	0	No	No	No	No	5	6
90	4x60	5x42	ccr8_off	1.67	0	No	No	No	No	8	2
91	6x49	6x53	ccr8_off	1.6	0	No	No	No	No	5	6
92	7x54	8x54	ccr8_off	1.58	0	No	No	No	No	6	6
93	1x54	1x58	ccr8_off	1.54	0	Yes	Yes	No	No	7	4
94	3x48	5x53	ccr8_off	1.54	0	No	No	No	No	6	6
95	2x38	2x39	ccr8_off	1.52	0	No	No	No	No	6	7
96	4x38	4x39	ccr8_off	1.52	0	No	No	No	No	7	3
97	4x41	4x44	ccr8_off	1.51	0	Yes	No	No	No	4	3
98	1x33	1x37	ccr8_off	1.49	0	No	No	No	No	4	5
99	1x37	1x41	ccr8_off	1.49	0	No	No	No	No	5	5
100	4x44	4x45	ccr8_off	1.47	0	No	No	No	No	3	5
101	6x39	6x42	ccr8_off	1.47	0	No	No	No	No	5	5
102	1x45	7x47	ccr8_off	1.4	0	No	No	No	No	5	6
103	1x52	1x55	ccr8_off	1.38	0	No	No	No	No	6	4
104	7x55	7x56	ccr8_off	1.31	0	No	No	No	No	7	5
105	7x31	7x32	ccr8_off	1.25	0	No	No	No	No	4	3
106	I1x48	I1x51	ccr8_off	1.24	0	No	No	No	No	6	7
107	I2x52	I2x55	ccr8_off	1.19	0	No	No	No	No	5	4
108	Lig	Lig	Shared	3014.82	307.96	Yes	Yes	Yes	Yes	0	0
109	E2.G179	Lig	Shared	8.94	1.86	No	No	Yes	Yes	6	0
110	E2.D178	Lig	Shared	25.38	25.29	No	No	Yes	Yes	1	0
111	1x32	2x64	Shared	5.64	7.05	No	No	No	No	4	5
112	1x35	2x64	Shared	5.54	2.77	No	No	No	No	5	5
113	1x39	2x60	Shared	5.64	12.4	Yes	Yes	No	No	7	5
114	1x39	7x39	Shared	4.84	12.09	Yes	Yes	No	No	7	4
115	1x39	7x42	Shared	5.16	5.16	Yes	Yes	Yes	Yes	7	7
116	1x43	1x47	Shared	3.65	2.44	Yes	No	No	No	6	6
117	1x43	2x57	Shared	9.65	7.5	Yes	No	Yes	Yes	6	7
118	1x43	2x58	Shared	4.33	7.22	Yes	No	No	No	6	9
119	1x44	1x45	Shared	3.93	2.62	No	No	No	No	5	5
120	1x46	1x50	Shared	4.47	4.47	No	No	Yes	No	8	9
121	1x46	2x54	Shared	4.85	6.46	No	No	Yes	No	8	5
122	1x50	2x50	Shared	12.12	10.77	Yes	No	Yes	Yes	9	9
123	1x50	7x50	Shared	6.52	6.52	Yes	No	No	No	9	9
124	1x60	8x53	Shared	17.69	5.9	No	Yes	Yes	No	5	5
125	8x53	I1x48	Shared	7.86	15.72	Yes	No	No	No	5	6
126	I1x49	I1x51	Shared	4.95	3.71	No	No	No	No	6	7
127	2x44	I1x50	Shared	4.15	5.54	No	Yes	No	No	5	6
128	2x37	2x40	Shared	7.36	4.42	No	No	No	No	7	8
129	2x38	2x42	Shared	7.25	10.88	No	No	Yes	Yes	6	6
130	2x40	8x49	Shared	8.3	5.53	No	No	No	No	8	6
131	2x42	3x45	Shared	4.69	4.69	Yes	Yes	No	No	6	5
132	2x42	3x46	Shared	3.59	4.79	Yes	Yes	No	No	6	9
133	2x45	3x42	Shared	12.08	9.67	No	No	Yes	Yes	9	7
134	2x45	4x46	Shared	9.45	7.87	No	No	No	No	9	7
135	2x46	7x49	Shared	5.49	5.49	No	No	No	No	9	9
136	2x49	3x38	Shared	6.52	6.52	No	No	No	Yes	8	6
137	2x50	7x45	Shared	3.78	5.04	Yes	Yes	Yes	Yes	9	9
138	2x50	7x46	Shared	6.22	4.67	Yes	Yes	Yes	No	9	8
139	2x50	7x49	Shared	4.04	6.73	Yes	Yes	No	No	9	9
140	2x53	3x32	Shared	4.13	9.28	Yes	Yes	Yes	No	6	6
141	2x53	3x35	Shared	4.52	4.52	Yes	Yes	No	No	6	8
142	2x53	7x45	Shared	11.31	6.79	Yes	Yes	Yes	Yes	6	9
143	2x53	7x46	Shared	4.19	5.59	Yes	Yes	Yes	No	6	8
144	2x57	7x42	Shared	9.65	20.36	Yes	Yes	Yes	Yes	7	7
145	2x59	E1x52	Shared	10.72	8.57	No	No	Yes	Yes	6	7
146	2x59	3x28	Shared	6.55	11.8	No	No	No	No	6	4
147	2x62	E1x52	Shared	5.16	6.19	No	No	Yes	Yes	4	7
148	2x63	E1x50	Shared	4.82	10.61	No	No	Yes	Yes	5	8
149	2x63	E2.Q182	Shared	4.51	4.51	No	No	No	Yes	5	2
150	2x66	E1x49	Shared	6.53	5.22	No	No	Yes	No	5	5
151	E1x49	E2.L181	Shared	5.32	11.98	Yes	No	No	No	5	4
152	E1x50	E1x52	Shared	16.04	19.04	Yes	Yes	Yes	Yes	8	7
153	E1x50	E2.V174	Shared	3.68	3.68	Yes	Yes	No	No	8	4
154	E1x50	E2x50	Shared	9.14	15.67	Yes	Yes	No	No	8	9
155	E1x51	E1x52	Shared	3.93	3.93	No	No	Yes	Yes	3	7
156	3x22	E2.V174	Shared	4.76	4.76	No	No	No	No	4	4
157	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
158	3x27	3x31	Shared	5.24	6.55	No	No	No	No	5	6
159	3x29	4x65	Shared	13.99	10.17	No	No	No	No	6	4
160	3x30	4x62	Shared	5.13	1.71	No	No	No	No	5	4
161	3x32	3x33	Shared	8.94	12.91	Yes	No	Yes	Yes	6	3
162	3x33	4x57	Shared	4.99	3.75	Yes	Yes	No	No	3	6
163	3x33	4x61	Shared	8.21	12.89	Yes	Yes	No	No	3	4
164	3x33	4x65	Shared	6.95	10.92	Yes	Yes	No	No	3	4
165	3x34	4x57	Shared	6.08	10.64	No	No	No	No	4	6
166	3x36	3x37	Shared	10.32	10.32	No	No	Yes	Yes	7	6
167	3x36	5x43	Shared	3.73	8.71	No	No	No	No	7	4
168	3x36	6x48	Shared	20.04	6.01	No	No	Yes	Yes	7	8
169	3x37	3x41	Shared	4.13	6.19	Yes	Yes	Yes	Yes	6	4
170	3x37	5x42	Shared	4.78	5.97	Yes	Yes	No	No	6	2
171	3x38	4x50	Shared	9.88	6.18	No	Yes	Yes	No	6	9
172	3x39	7x45	Shared	5.58	5.58	No	No	Yes	Yes	9	9
173	3x41	4x49	Shared	3.93	6.55	Yes	Yes	No	No	4	6
174	3x41	5x46	Shared	4.87	6.09	Yes	Yes	No	No	4	5
175	3x42	4x46	Shared	4.19	4.19	Yes	Yes	No	No	7	7
176	3x42	4x49	Shared	10.49	14.42	Yes	Yes	No	No	7	6
177	3x42	4x50	Shared	6.01	12.03	Yes	Yes	Yes	No	7	9
178	3x46	7x53	Shared	4.79	3.59	No	No	Yes	Yes	9	9
179	3x47	5x54	Shared	7.93	6.61	No	No	Yes	Yes	9	7
180	3x47	5x58	Shared	8.9	5.09	No	No	Yes	Yes	9	8
181	3x49	I2x57	Shared	17.87	15.48	No	Yes	Yes	Yes	8	7
182	3x51	3x55	Shared	13.88	12.62	Yes	Yes	No	No	8	7
183	3x51	3x56	Shared	7.62	8.71	Yes	Yes	No	No	8	5
184	3x51	5x57	Shared	8.06	5.38	Yes	Yes	No	No	8	7
185	3x51	5x60	Shared	4.78	5.97	Yes	Yes	No	No	8	3
186	3x53	I2x57	Shared	4.15	6.91	No	No	Yes	Yes	8	7
187	3x54	5x61	Shared	7.68	3.07	No	No	No	No	8	8
188	I2x52	I2x56	Shared	5.05	6.31	No	No	No	No	5	5
189	4x61	5x39	Shared	7.37	7.37	No	No	No	No	4	5
190	4x63	4x64	Shared	7.87	3.93	No	No	No	No	5	5
191	4x64	5x35	Shared	4.01	27.06	No	No	No	Yes	5	2
192	E2.A175	E2.F186	Shared	4.16	9.71	No	No	No	Yes	2	5
193	E2.E177	E2.Q182	Shared	3.82	5.1	No	No	No	Yes	1	2
194	E2.F186	E2x51	Shared	11.35	4.13	No	Yes	No	Yes	5	2
195	5x34	5x35	Shared	9.28	4.64	No	No	No	Yes	1	2
196	5x38	5x42	Shared	3.72	8.69	No	No	No	No	3	2
197	5x40	6x59	Shared	4.47	5.96	No	Yes	No	No	4	4
198	5x41	6x59	Shared	10.57	10.57	No	No	No	No	4	4
199	5x44	6x56	Shared	3.62	6.04	No	No	No	No	5	5
200	5x45	5x48	Shared	4.28	2.85	No	No	No	No	4	5
201	5x461	5x50	Shared	4.06	4.06	No	No	Yes	No	5	9
202	5x47	6x52	Shared	13.73	9.61	No	No	No	No	8	8
203	5x49	5x50	Shared	5.08	3.39	No	No	Yes	No	6	9
204	5x51	6x45	Shared	3.65	6.09	No	No	No	No	6	5
205	5x54	6x41	Shared	13.11	5.24	Yes	Yes	No	No	7	7
206	5x58	6x37	Shared	3.79	5.05	Yes	Yes	No	No	8	7
207	5x58	6x41	Shared	10.09	5.05	Yes	Yes	No	No	8	7
208	6x36	7x56	Shared	7.45	4.47	No	No	No	No	7	5
209	6x47	7x45	Shared	4.53	4.53	No	Yes	Yes	Yes	7	9
210	6x48	7x41	Shared	9.88	4.94	Yes	Yes	No	No	8	7
211	6x48	7x45	Shared	10.58	19.04	Yes	Yes	Yes	Yes	8	9
212	6x49	6x50	Shared	5.3	3.53	No	No	No	No	5	9
213	6x54	7x37	Shared	4.76	7.93	No	No	No	No	4	7
214	6x56	6x60	Shared	12.18	12.18	No	No	No	No	5	3
215	7x26	7x30	Shared	4.28	2.85	No	No	No	No	2	4
216	7x38	7x42	Shared	8.16	12.83	No	No	Yes	Yes	5	7
217	7x45	7x46	Shared	4.42	10.32	Yes	Yes	Yes	No	9	8
218	8x56	8x57	Shared	8.2	2.73	No	No	No	No	4	5
219	1x53	7x50	Shared	3.53	3.53	No	No	No	No	8	9
220	3x44	5x50	Shared	3.5	3.5	No	No	Yes	No	7	9
221	4x59	4x60	Shared	3.39	3.39	No	No	No	No	4	8
222	1x54	2x47	Shared	3.25	3.25	Yes	Yes	No	No	7	8
223	6x40	7x52	Shared	3.07	7.68	No	No	No	No	7	8
224	3x24	3x27	Shared	3.04	3.04	No	No	No	No	5	5
225	3x44	5x53	Shared	3.04	6.08	No	No	No	No	7	6
226	4x38	4x41	Shared	3.01	1.51	No	No	Yes	No	7	4
227	3x22	3x26	Shared	3	1.5	No	No	No	No	4	7
228	1x55	1x59	Shared	2.98	1.49	No	No	No	No	4	4
229	2x41	I1x50	Shared	2.98	2.98	No	No	No	No	6	6
230	3x52	I2x56	Shared	2.98	4.47	No	No	No	No	5	5
231	5x55	5x59	Shared	2.92	2.92	No	No	No	No	4	5
232	2x42	4x42	Shared	2.9	4.35	Yes	Yes	No	No	6	7
233	3x54	5x64	Shared	2.87	2.87	No	No	No	No	8	6
234	1x54	2x44	Shared	2.85	4.28	Yes	Yes	No	Yes	7	5
235	1x54	2x51	Shared	2.85	2.85	Yes	Yes	No	No	7	7
236	6x61	7x27	Shared	2.79	6.97	No	No	No	No	1	5
237	I2x53	I2x57	Shared	2.77	2.77	No	No	Yes	Yes	5	7
238	6x43	6x47	Shared	2.77	4.16	No	No	No	Yes	6	7
239	6x57	7x30	Shared	2.77	1.38	No	Yes	No	No	5	4
240	5x44	6x52	Shared	2.72	4.09	No	No	No	No	5	8
241	3x37	4x56	Shared	2.67	8.01	Yes	Yes	No	No	6	4
242	2x56	2x57	Shared	2.64	2.64	No	No	Yes	Yes	6	7
243	3x41	4x52	Shared	2.59	3.89	Yes	Yes	No	No	4	4
244	6x51	7x37	Shared	2.59	7.78	No	No	No	No	6	7
245	1x39	2x61	Shared	2.5	3.75	Yes	Yes	No	No	7	7
246	1x41	1x45	Shared	2.44	2.44	No	No	No	No	5	5
247	7x56	8x47	Shared	1.84	1.84	No	No	No	No	5	8
248	4x41	4x42	Shared	1.75	1.75	Yes	No	No	No	4	7
249	1x48	1x49	Shared	1.71	1.71	No	No	No	No	5	7
250	1x59	1x60	Shared	1.71	3.42	No	No	No	Yes	4	5
251	3x38	4x53	Shared	1.71	1.71	No	Yes	No	No	6	7
252	1x30	1x31	Shared	1.7	1.7	No	No	No	No	4	1
253	6x54	7x33	Shared	1.7	1.7	No	No	No	No	4	5
254	1x40	2x61	Shared	1.69	1.69	No	No	No	No	6	7
255	3x23	3x27	Shared	1.6	1.6	No	No	No	No	1	5
256	7x48	7x51	Shared	1.6	1.6	No	No	No	No	7	5
257	1x36	2x65	Shared	1.58	4.73	No	No	No	No	5	4
258	6x53	6x57	Shared	1.49	1.49	No	No	No	Yes	6	5
259	3x34	4x54	Shared	1.47	4.42	No	No	No	No	4	3
260	4x43	4x47	Shared	1.47	1.47	No	No	No	No	3	4
261	4x54	4x59	Shared	1.47	2.94	No	No	No	No	3	4
262	7x25	7x29	Shared	1.44	1.44	No	No	No	No	3	4
263	1x54	2x48	Shared	1.43	4.28	Yes	Yes	No	No	7	6
264	5x65	6x34	Shared	1.43	5.71	No	No	No	No	8	6
265	8x48	8x51	Shared	1.35	9.45	No	No	No	No	5	8
266	2x54	2x55	Shared	1.31	1.31	Yes	No	No	No	5	4
267	4x38	4x40	Shared	1.29	1.29	No	No	No	No	7	4
268	8x50	8x54	Shared	1.22	10.96	Yes	Yes	No	No	8	6
269	1x25	Lig	ccr8_on	0	16.08	No	No	Yes	Yes	0	0
270	2x63	Lig	ccr8_on	0	8.56	No	No	Yes	Yes	5	0
271	E2.V180	Lig	ccr8_on	0	6.97	No	No	Yes	Yes	4	0
272	2x60	Lig	ccr8_on	0	10.02	No	No	Yes	Yes	5	0
273	7x35	Lig	ccr8_on	0	5.56	No	No	Yes	Yes	4	0
274	7x38	Lig	ccr8_on	0	8.62	No	No	Yes	Yes	5	0
275	3x32	Lig	ccr8_on	0	8.17	Yes	No	Yes	Yes	6	0
276	E2x50	Lig	ccr8_on	0	4.86	No	No	Yes	Yes	9	0
277	3x33	Lig	ccr8_on	0	5.64	Yes	Yes	Yes	Yes	3	0
278	E2x51	Lig	ccr8_on	0	23.86	No	Yes	Yes	Yes	2	0
279	5x43	Lig	ccr8_on	0	4.08	No	No	Yes	Yes	4	0
280	6x55	Lig	ccr8_on	0	5.32	No	No	Yes	Yes	5	0
281	7x34	Lig	ccr8_on	0	6.18	No	No	Yes	Yes	4	0
282	E2.Q182	Lig	ccr8_on	0	9.42	No	Yes	Yes	Yes	2	0
283	E2.F186	Lig	ccr8_on	0	4.08	No	Yes	Yes	Yes	5	0
284	Lig	NT.D26	ccr8_on	0	15.49	Yes	Yes	No	No	0	0
285	Lig	NT.P24	ccr8_on	0	27.17	Yes	Yes	No	No	0	0
286	Lig	NT.C25	ccr8_on	0	5.59	Yes	Yes	No	No	0	0
287	7x24	Lig	ccr8_on	0	6.98	No	No	Yes	Yes	0	0
288	7x27	Lig	ccr8_on	0	5.28	No	No	Yes	Yes	5	0
289	Lig	NT.S22	ccr8_on	0	13.4	Yes	Yes	No	No	0	0
290	Lig	NT.I20	ccr8_on	0	22.62	Yes	Yes	No	No	0	0
291	Lig	NT.C21	ccr8_on	0	7.28	Yes	Yes	No	No	0	0
292	5x32	Lig	ccr8_on	0	14.07	No	No	Yes	Yes	3	0
293	5x33	Lig	ccr8_on	0	7.51	No	No	Yes	Yes	1	0
294	6x64	Lig	ccr8_on	0	4.18	No	No	Yes	Yes	0	0
295	E3.D270	Lig	ccr8_on	0	4.04	No	No	Yes	Yes	0	0
296	NT.C21	NT.S22	ccr8_on	0	5.16	No	No	No	No	0	0
297	7x24	NT.C25	ccr8_on	0	7.28	No	No	No	No	0	0
298	1x26	7x28	ccr8_on	0	6.65	No	No	No	No	0	4
299	1x27	1x32	ccr8_on	0	7.27	No	No	No	No	0	4
300	1x28	1x30	ccr8_on	0	3.96	No	No	No	No	0	4
301	1x56	1x60	ccr8_on	0	5.12	No	No	No	Yes	7	5
302	1x56	8x50	ccr8_on	0	3.93	No	No	Yes	Yes	7	8
303	1x56	8x54	ccr8_on	0	4.47	No	No	No	No	7	6
304	1x57	2x43	ccr8_on	0	4.15	No	No	No	No	6	8
305	1x57	2x44	ccr8_on	0	5.54	No	No	No	Yes	6	5
306	2x40	I1x48	ccr8_on	0	4.15	No	No	No	No	8	6
307	2x37	2x39	ccr8_on	0	6.4	No	No	No	No	7	7
308	2x38	3x49	ccr8_on	0	4.2	No	No	No	Yes	6	8
309	2x39	3x49	ccr8_on	0	4.34	No	No	No	Yes	7	8
310	2x42	3x49	ccr8_on	0	9.2	Yes	Yes	No	Yes	6	8
311	2x46	2x50	ccr8_on	0	5.43	No	No	Yes	Yes	9	9
312	2x50	3x39	ccr8_on	0	4.42	Yes	Yes	No	No	9	9
313	2x52	3x31	ccr8_on	0	6.09	No	No	No	No	7	6
314	2x53	2x57	ccr8_on	0	4.29	Yes	Yes	Yes	Yes	6	7
315	2x53	7x42	ccr8_on	0	7.5	Yes	Yes	Yes	Yes	6	7
316	2x54	2x57	ccr8_on	0	11.8	Yes	No	Yes	Yes	5	7
317	2x58	2x59	ccr8_on	0	4.33	No	No	No	No	9	6
318	2x62	2x66	ccr8_on	0	13.79	No	No	No	No	4	5
319	2x62	E1x51	ccr8_on	0	7.57	No	No	No	No	4	3
320	3x28	E1x50	ccr8_on	0	6.13	No	No	Yes	Yes	4	8
321	3x37	5x46	ccr8_on	0	5.86	Yes	Yes	No	No	6	5
322	3x38	3x42	ccr8_on	0	3.96	No	Yes	Yes	Yes	6	7
323	3x40	5x461	ccr8_on	0	5.24	No	No	No	No	7	5
324	3x40	6x48	ccr8_on	0	9.31	No	No	Yes	Yes	7	8
325	3x43	7x53	ccr8_on	0	4.84	No	No	Yes	Yes	8	9
326	3x47	5x57	ccr8_on	0	6.89	No	No	No	No	9	7
327	3x50	5x58	ccr8_on	0	12.35	No	No	Yes	Yes	9	8
328	3x50	7x53	ccr8_on	0	6.17	No	No	Yes	Yes	9	9
329	4x65	E2x51	ccr8_on	0	4.96	No	No	No	Yes	4	2
330	E2.A175	E2.E177	ccr8_on	0	4.53	No	No	No	No	2	1
331	E2.L181	E2.S176	ccr8_on	0	4.5	No	No	No	No	4	3
332	E2.E177	E2.F186	ccr8_on	0	7	No	No	No	Yes	1	5
333	E2.Q182	E2.V180	ccr8_on	0	5.73	No	Yes	No	No	2	4
334	E2.F186	E2.Q182	ccr8_on	0	7.03	No	Yes	No	Yes	5	2
335	E2x51	E2x52	ccr8_on	0	8.9	No	Yes	No	No	2	4
336	5x36	E2x51	ccr8_on	0	4.78	No	Yes	No	Yes	3	2
337	5x35	E2x52	ccr8_on	0	4.94	No	Yes	No	No	2	4
338	5x32	E2.F186	ccr8_on	0	6.49	No	No	No	Yes	3	5
339	5x31	E2.N188	ccr8_on	0	5.28	No	No	No	No	4	5
340	5x31	5x35	ccr8_on	0	8.76	No	No	No	Yes	4	2
341	5x36	5x40	ccr8_on	0	8.39	No	Yes	No	Yes	3	4
342	5x36	6x58	ccr8_on	0	6.01	No	Yes	No	No	3	4
343	5x36	6x62	ccr8_on	0	9.18	No	Yes	No	No	3	3
344	5x37	6x59	ccr8_on	0	4.64	No	No	No	No	3	4
345	5x37	6x62	ccr8_on	0	4.64	No	No	No	No	3	3
346	5x37	6x63	ccr8_on	0	5.83	No	No	No	No	3	0
347	5x39	5x40	ccr8_on	0	4.39	No	No	No	Yes	5	4
348	5x40	6x58	ccr8_on	0	4.39	No	Yes	No	No	4	4
349	5x41	6x56	ccr8_on	0	4.29	No	No	No	No	4	5
350	5x41	6x63	ccr8_on	0	4.98	No	No	No	No	4	0
351	5x47	5x51	ccr8_on	0	6.09	No	No	No	No	8	6
352	5x51	6x48	ccr8_on	0	7.02	No	No	Yes	Yes	6	8
353	5x54	5x58	ccr8_on	0	13.41	Yes	Yes	Yes	Yes	7	8
354	5x54	6x44	ccr8_on	0	7.93	Yes	Yes	No	No	7	9
355	5x55	6x45	ccr8_on	0	4.24	No	No	No	No	4	5
356	5x56	5x60	ccr8_on	0	8.69	No	No	No	No	4	3
357	5x62	6x34	ccr8_on	0	4.28	No	No	No	No	5	6
358	5x62	6x37	ccr8_on	0	4.47	No	No	No	No	5	7
359	5x62	6x38	ccr8_on	0	4.15	No	No	No	No	5	4
360	5x65	6x30	ccr8_on	0	4.23	No	No	No	No	8	0
361	5x68	6x30	ccr8_on	0	6.47	No	No	No	No	0	0
362	6x28	6x30	ccr8_on	0	5.24	No	No	No	No	0	0
363	6x32	6x36	ccr8_on	0	7.05	No	No	No	No	0	7
364	6x32	8x48	ccr8_on	0	6.75	No	No	No	No	0	5
365	6x45	6x49	ccr8_on	0	4.47	No	No	No	No	5	5
366	6x47	6x48	ccr8_on	0	9.02	No	Yes	Yes	Yes	7	8
367	6x47	7x48	ccr8_on	0	3.93	No	Yes	No	No	7	7
368	6x51	6x55	ccr8_on	0	14.61	No	No	No	No	6	5
369	6x51	7x41	ccr8_on	0	10.57	No	No	No	No	6	7
370	6x58	7x30	ccr8_on	0	4.42	No	No	No	No	4	4
371	6x60	6x65	ccr8_on	0	7.14	No	No	No	No	3	0
372	6x63	6x65	ccr8_on	0	4.37	No	No	No	No	0	0
373	7x26	E3.L269	ccr8_on	0	4.28	No	No	No	No	2	0
374	7x32	7x36	ccr8_on	0	5.05	No	No	No	No	3	5
375	7x49	7x53	ccr8_on	0	6.98	No	No	Yes	Yes	9	9
376	7x52	7x53	ccr8_on	0	7.25	No	No	Yes	Yes	8	9
377	7x54	8x50	ccr8_on	0	8.32	No	No	Yes	Yes	6	8
378	7x55	8x50	ccr8_on	0	5.36	No	No	Yes	Yes	7	8
379	6x47	7x43	ccr8_on	0	3.89	No	Yes	No	No	7	5
380	5x35	E2.Y187	ccr8_on	0	3.86	No	Yes	Yes	No	2	5
381	1x38	7x39	ccr8_on	0	3.77	No	No	No	No	5	4
382	NT.P24	NT.S23	ccr8_on	0	3.56	No	No	No	No	0	0
383	3x48	5x57	ccr8_on	0	3.42	No	No	No	No	6	7
384	1x53	2x47	ccr8_on	0	3.39	No	No	No	No	8	8
385	1x60	8x57	ccr8_on	0	3.27	No	Yes	No	No	5	5
386	3x54	3x55	ccr8_on	0	3.21	No	No	No	No	8	7
387	7x31	Lig	ccr8_on	0	3.17	No	No	Yes	Yes	4	0
388	1x42	7x47	ccr8_on	0	3.17	No	No	No	No	6	6
389	5x65	6x33	ccr8_on	0	3.15	No	No	No	No	8	0
390	2x41	4x39	ccr8_on	0	3.07	No	No	No	No	6	3
391	7x23	Lig	ccr8_on	0	3.01	No	No	Yes	Yes	0	0
392	1x47	1x51	ccr8_on	0	3	No	No	No	No	6	3
393	1x58	2x44	ccr8_on	0	2.98	No	No	No	Yes	4	5
394	1x29	1x33	ccr8_on	0	2.95	No	No	No	No	0	4
395	1x42	7x43	ccr8_on	0	2.95	No	No	No	No	6	5
396	3x55	5x64	ccr8_on	0	2.87	No	No	No	No	7	6
397	1x35	7x39	ccr8_on	0	2.85	No	No	No	No	5	4
398	2x52	3x34	ccr8_on	0	2.85	No	No	No	No	7	4
399	6x42	6x46	ccr8_on	0	2.85	No	No	No	No	5	5
400	3x21	E1x50	ccr8_on	0	2.81	No	No	Yes	Yes	7	8
401	1x52	8x54	ccr8_on	0	2.77	No	No	No	No	6	6
402	3x45	4x45	ccr8_on	0	2.77	No	No	No	No	5	5
403	5x66	I3.Q229	ccr8_on	0	2.71	No	No	No	No	5	0
404	4x40	4x44	ccr8_on	0	2.59	No	No	No	No	4	3
405	6x35	6x39	ccr8_on	0	2.51	No	No	No	No	6	5
406	6x32	6x35	ccr8_on	0	2.48	No	No	No	No	0	6
407	3x52	I2x57	ccr8_on	0	2.43	No	No	Yes	Yes	5	7
408	5x64	5x67	ccr8_on	0	2.34	No	No	No	No	6	5
409	3x29	3x30	ccr8_on	0	1.86	No	No	No	No	6	5
410	E2.G179	E2.S176	ccr8_on	0	1.86	No	No	No	No	6	3
411	1x24	Lig	ccr8_on	0	1.71	No	No	Yes	Yes	0	0
412	2x41	4x43	ccr8_on	0	1.59	No	No	No	No	6	3
413	7x36	7x37	ccr8_on	0	1.59	No	No	No	No	5	7
414	7x25	7x26	ccr8_on	0	1.55	No	No	No	No	3	2
415	7x28	NT.C25	ccr8_on	0	1.53	No	No	No	No	4	0
416	I2x55	I2x56	ccr8_on	0	1.52	No	No	No	No	4	5
417	7x40	7x43	ccr8_on	0	1.52	No	No	No	No	7	5
418	4x52	4x55	ccr8_on	0	1.51	No	No	No	No	4	4
419	1x34	1x37	ccr8_on	0	1.49	No	No	No	No	5	5
420	1x44	1x48	ccr8_on	0	1.49	No	No	No	No	5	5
421	5x45	5x49	ccr8_on	0	1.47	No	No	No	No	4	6
422	5x48	5x52	ccr8_on	0	1.47	No	No	No	No	5	4
423	6x39	7x52	ccr8_on	0	1.47	No	No	No	No	5	8
424	1x29	1x30	ccr8_on	0	1.46	No	No	No	No	0	4
425	8x51	8x52	ccr8_on	0	1.44	No	No	No	No	8	6
426	3x22	E2.Q173	ccr8_on	0	1.42	No	No	No	No	4	4
427	1x32	2x65	ccr8_on	0	1.41	No	No	No	No	4	4
428	1x41	1x42	ccr8_on	0	1.38	No	No	No	No	5	6
429	6x57	6x60	ccr8_on	0	1.38	No	Yes	No	No	5	3
430	6x57	E3.L269	ccr8_on	0	1.38	No	Yes	No	No	5	0
431	6x34	I3.Q229	ccr8_on	0	1.37	No	No	No	No	6	0
432	E2.N188	E2.Q189	ccr8_on	0	1.32	No	No	No	No	5	3
433	1x37	1x38	ccr8_on	0	1.31	No	No	No	No	5	5
434	6x31	6x35	ccr8_on	0	1.29	No	No	No	No	0	6

Orange: nodes, hubs and links specific of ccr8_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccr8_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	ccr8_off Avg Int. Strength	ccr8_on Avg Int. Strength	ccr8_off Num Of Links	ccr8_on Num Of Links	ConSurf
1	1x43	ccr8_off	5.39	5.72	4	3	6
2	1x50	ccr8_off	7.15	7.25333	4	3	9
3	2x54	ccr8_off	3.64	6.52333	4	3	5
4	E1x49	ccr8_off	5.0275	8.6	4	2	5
5	3x32	ccr8_off	5.33	10.12	4	3	6
6	4x41	ccr8_off	2.3275	1.63	4	2	4
7	4x50	ccr8_off	6.93	9.105	4	2	9
8	E2.Y187	ccr8_off	10.495	3.86	4	1	5
9	5x50	ccr8_off	4.8375	3.65	4	3	9
10	7x46	ccr8_off	4.362	6.86	5	3	8
11	8x53	ccr8_off	10.3725	10.81	4	2	5
12	Lig	Shared	472.831	26.8232	13	34	0
13	1x39	Shared	6.31167	8.35	6	4	7
14	1x54	Shared	2.384	3.665	5	4	7
15	2x42	Shared	4.6075	6.782	4	5	6
16	2x50	Shared	6.54	6.17667	4	6	9
17	2x53	Shared	5.632	6.32833	5	6	6
18	2x57	Shared	6.3975	9.318	4	5	7
19	E1x50	Shared	7.52	9.65667	5	6	8
20	E1x52	Shared	7.668	9.4325	5	4	7
21	3x33	Shared	6.536	9.222	5	5	3
22	3x37	Shared	5.475	7.27	4	5	6
23	3x41	Shared	3.88	5.68	4	4	4
24	3x42	Shared	8.1925	8.854	4	5	7
25	3x51	Shared	7.73333	8.17	6	4	8
26	I2x57	Shared	7.1375	6.8975	4	4	7
27	5x54	Shared	7.208	8.2975	5	4	7
28	5x58	Shared	5.562	8.19	5	5	8
29	6x48	Shared	11.1275	9.22333	4	6	8
30	7x42	Shared	7.0325	11.4625	4	4	7
31	7x45	Shared	6.7	8.55	6	6	9
32	7x53	Shared	5.814	5.766	5	5	9
33	8x50	Shared	5.3	7.1425	4	4	8
34	1x60	ccr8_on	9.7	4.4275	2	4	5
35	2x44	ccr8_on	3.5	4.585	2	4	5
36	3x38	ccr8_on	6.03667	4.5925	3	4	6
37	3x49	ccr8_on	17.87	8.305	1	4	8
38	E2.Q182	ccr8_on	4.165	6.358	2	5	2
39	E2x51	ccr8_on	11.35	9.326	1	5	2
40	E2.F186	ccr8_on	7.51333	6.40667	3	6	5
41	5x35	ccr8_on	5.76667	9.852	3	5	2
42	5x36	ccr8_on	8.575	7.09	2	4	3
43	5x40	ccr8_on	8.415	5.7825	2	4	4
44	6x47	ccr8_on	4.46333	5.106	3	5	7
45	6x57	ccr8_on	2.13	1.4075	2	4	5

Orange: nodes, hubs and links specific of ccr8_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ccr8_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ccr8_off Recurrence	ccr8_on Recurrence	ccr8_off Hub1?	ccr8_on Hub1?	ccr8_off Hub2?	ccr8_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x60	ccr8_off	50.7515	7.23893	Yes	Yes	No	No	7	5
2	2x60	2x63	ccr8_off	49.4289	0	No	No	No	No	5	5
3	2x63	E2.Q182	ccr8_off	24.8704	0.338935	No	No	No	Yes	5	2
4	E2.E177	E2.Q182	ccr8_off	23.4275	1.34504	No	No	No	Yes	1	2
5	E2.E177	Lig	ccr8_off	21.9659	0	No	No	Yes	Yes	1	0
6	2x57	7x42	ccr8_off	11.5165	3.98873	Yes	Yes	Yes	Yes	7	7
7	7x46	7x47	ccr8_off	11.0168	0	Yes	No	No	No	8	6
8	3x32	7x42	ccr8_off	69.4146	0	Yes	No	Yes	Yes	6	7
9	1x46	7x46	ccr8_off	11.7382	0	No	No	Yes	No	8	8
10	1x50	2x51	ccr8_off	14.6051	0	Yes	No	No	No	9	7
11	8x49	I1x48	ccr8_off	12.8466	0	No	No	No	No	6	6
12	8x49	8x50	ccr8_off	16.5552	0	No	No	Yes	Yes	6	8
13	7x53	8x50	ccr8_off	21.3948	0	Yes	Yes	Yes	Yes	9	8
14	2x42	3x45	ccr8_off	93.5072	3.13604	Yes	Yes	No	No	6	5
15	3x45	4x49	ccr8_off	94.0896	0	No	No	No	No	5	6
16	3x41	4x49	ccr8_off	98.4782	8.38774	Yes	Yes	No	No	4	6
17	3x33	5x43	ccr8_off	42.0042	0	Yes	Yes	No	No	3	4
18	2x53	6x48	ccr8_off	41.2903	0	Yes	Yes	Yes	Yes	6	8
19	1x54	2x51	ccr8_off	12.8053	1.50558	Yes	Yes	No	No	7	7
20	3x43	5x54	ccr8_off	56.7333	0	No	No	Yes	Yes	8	7
21	3x43	6x40	ccr8_off	58.612	0	No	No	No	No	8	7
22	6x40	7x53	ccr8_off	62.2793	0	No	No	Yes	Yes	7	9
23	3x47	5x54	ccr8_off	23.4463	0.124871	No	No	Yes	Yes	9	7
24	5x58	6x41	ccr8_off	22.3454	1.38428	Yes	Yes	No	No	8	7
25	5x54	6x41	ccr8_off	23.4463	0.0463805	Yes	Yes	No	No	7	7
26	5x57	5x58	ccr8_off	26.2005	0	No	No	Yes	Yes	7	8
27	4x41	4x42	ccr8_off	12.8466	6.2471	Yes	No	No	No	4	7
28	2x42	4x42	ccr8_off	14.0903	7.79193	Yes	Yes	No	No	6	7
29	5x43	6x55	ccr8_off	12.4859	0	No	No	No	No	4	5
30	6x49	6x50	ccr8_off	17.8966	1.1274	No	No	No	No	5	9
31	6x50	7x37	ccr8_off	22.2026	0	No	No	No	No	9	7
32	6x51	7x37	ccr8_off	27.8387	5.65129	No	No	No	No	6	7
33	3x32	6x51	ccr8_off	29.2064	0	Yes	No	No	No	6	6
34	7x26	7x30	ccr8_off	12.05	6.0366	No	No	No	No	2	4
35	6x57	7x30	ccr8_off	13.523	4.9092	No	Yes	No	No	5	4
36	6x53	6x57	ccr8_off	14.9884	1.8802	No	No	No	Yes	6	5
37	6x49	6x53	ccr8_off	16.4462	0	No	No	No	No	5	6
38	1x39	7x42	Shared	63.3952	12.851	Yes	Yes	Yes	Yes	7	7
39	2x53	7x46	Shared	20.523	45.6099	Yes	Yes	Yes	No	6	8
40	2x53	3x32	Shared	54.073	82.1435	Yes	Yes	Yes	No	6	6
41	1x50	2x50	Shared	16.1306	22.6087	Yes	No	Yes	Yes	9	9
42	2x50	7x45	Shared	13.7897	68.2686	Yes	Yes	Yes	Yes	9	9
43	3x46	7x53	Shared	81.0137	50.4549	No	No	Yes	Yes	9	9
44	2x42	3x46	Shared	81.7389	49.3061	Yes	Yes	No	No	6	9
45	3x37	3x41	Shared	100	11.3775	Yes	Yes	Yes	Yes	6	4
46	3x36	3x37	Shared	98.497	16.3224	No	No	Yes	Yes	7	6
47	3x36	5x43	Shared	44.8486	18.7913	No	No	No	No	7	4
48	3x32	3x33	Shared	46.979	16.1012	Yes	No	Yes	Yes	6	3
49	3x36	6x48	Shared	58.9577	20.1862	No	No	Yes	Yes	7	8
50	E1x50	E1x52	Shared	13.9288	11.3061	Yes	Yes	Yes	Yes	8	7
51	3x47	5x58	Shared	22.3454	18.3203	No	No	Yes	Yes	9	8
52	3x51	5x57	Shared	23.8559	13.932	Yes	Yes	No	No	8	7
53	2x63	E1x50	Shared	23.42	15.616	No	No	Yes	Yes	5	8
54	6x48	7x45	Shared	17.5922	22.8299	Yes	Yes	Yes	Yes	8	9
55	1x39	7x39	ccr8_on	3.14496	14.2674	Yes	Yes	No	No	7	4
56	1x43	2x57	ccr8_on	6.63561	10.6497	Yes	No	Yes	Yes	6	7
57	2x53	2x57	ccr8_on	0	12.2801	Yes	Yes	Yes	Yes	6	7
58	3x32	Lig	ccr8_on	0	65.5785	Yes	No	Yes	Yes	6	0
59	2x63	Lig	ccr8_on	0	16.433	No	No	Yes	Yes	5	0
60	E1x50	E2x50	ccr8_on	1.5706	15.3734	Yes	Yes	No	No	8	9
61	E2x50	Lig	ccr8_on	0	17.8173	No	No	Yes	Yes	9	0
62	2x53	7x45	ccr8_on	7.03765	56.2203	Yes	Yes	Yes	Yes	6	9
63	2x50	7x46	ccr8_on	5.92545	45.4494	Yes	Yes	Yes	No	9	8
64	1x50	7x50	ccr8_on	7.36079	21.8845	Yes	No	No	No	9	9
65	1x54	2x47	ccr8_on	1.84865	17.6353	Yes	Yes	No	No	7	8
66	1x53	2x47	ccr8_on	0	19.0588	No	No	No	No	8	8
67	1x53	7x50	ccr8_on	1.84865	20.4752	No	No	No	No	8	9
68	1x54	2x44	ccr8_on	5.53092	13.3219	Yes	Yes	No	Yes	7	5
69	1x60	8x53	ccr8_on	5.22657	16.9111	No	Yes	Yes	No	5	5
70	8x53	I1x48	ccr8_on	9.07041	18.4059	Yes	No	No	No	5	6
71	2x40	I1x48	ccr8_on	0	19.8937	No	No	No	No	8	6
72	2x37	2x40	ccr8_on	1.3151	22.6622	No	No	No	No	7	8
73	2x37	2x39	ccr8_on	0	24.1286	No	No	No	No	7	7
74	2x39	3x49	ccr8_on	0	25.5806	No	No	No	Yes	7	8
75	2x42	3x49	ccr8_on	0	36.9153	Yes	Yes	No	Yes	6	8
76	7x49	7x53	ccr8_on	0	99.2543	No	No	Yes	Yes	9	9
77	2x50	7x49	ccr8_on	2.74667	100	Yes	Yes	No	No	9	9
78	5x43	Lig	ccr8_on	0	18.7235	No	No	Yes	Yes	4	0
79	3x34	4x57	ccr8_on	2.47238	14.1889	No	No	No	No	4	6
80	3x33	4x57	ccr8_on	5.63989	15.7301	Yes	Yes	No	No	3	6
81	E1x50	E2.V174	ccr8_on	6.69197	11.2705	Yes	Yes	No	No	8	4
82	E2x51	Lig	ccr8_on	0	36.0591	No	Yes	Yes	Yes	2	0
83	3x50	5x58	ccr8_on	0	39.5947	No	No	Yes	Yes	9	8
84	3x50	7x53	ccr8_on	0	40.8006	No	No	Yes	Yes	9	9
85	3x47	5x57	ccr8_on	0	16.9503	No	No	No	No	9	7
86	3x49	I2x57	ccr8_on	1.3151	10.8602	No	Yes	Yes	Yes	8	7
87	5x35	E2x52	ccr8_on	0	12.0696	No	Yes	No	No	2	4
88	E2x51	E2x52	ccr8_on	0	13.5467	No	Yes	No	No	2	4
89	5x36	E2x51	ccr8_on	0	23.0083	No	Yes	No	Yes	3	2
90	5x36	6x58	ccr8_on	0	12.933	No	Yes	No	No	3	4
91	5x51	6x48	ccr8_on	0	13.0187	No	No	Yes	Yes	6	8
92	5x58	6x37	ccr8_on	9.63027	16.9111	Yes	Yes	No	No	8	7
93	5x62	6x37	ccr8_on	0	15.409	No	No	No	No	5	7
94	5x62	6x34	ccr8_on	0	12.3836	No	No	No	No	5	6
95	6x32	6x35	ccr8_on	0	10.6675	No	No	No	No	0	6
96	6x35	6x39	ccr8_on	0	13.7072	No	No	No	No	6	5
97	6x39	7x52	ccr8_on	0	15.2164	No	No	No	No	5	8
98	7x52	7x53	ccr8_on	0	18.2133	No	No	Yes	Yes	8	9
99	6x47	7x45	ccr8_on	2.92703	10.8031	No	Yes	Yes	Yes	7	9
100	6x58	7x30	ccr8_on	0	12.0304	No	No	No	No	4	4
101	6x47	7x43	ccr8_on	0	11.9412	No	Yes	No	No	7	5
102	2x53	7x42	ccr8_on	0	13.2256	Yes	Yes	Yes	Yes	6	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
E1x49	Lig	ccr8_off	3.96	0	1	0	1	0
E2.G179	Lig	Shared	8.94	1.86	0	1	1	0
E2.L181	Lig	ccr8_off	5.52	0	1	0	1	0
E2.S176	Lig	ccr8_off	6.26	0	0	0	1	0
E2.D178	Lig	Shared	25.38	25.29	0	0	1	0
E2.E177	Lig	ccr8_off	9.81	0	1	1	1	0
E2.Q173	Lig	ccr8_off	19.8	0	1	0	1	0
3x22	Lig	ccr8_off	10.12	0	1	0	1	0
E2.N188	Lig	ccr8_off	8.39	0	0	0	1	0
5x31	Lig	ccr8_off	7.89	0	1	0	1	0
E2.Q189	Lig	ccr8_off	11.09	0	1	0	1	0
1x39	2x60	Shared	5.64	12.4	4	0	2	1
1x39	7x38	ccr8_off	4.49	0	4	0	2	1
1x39	7x39	Shared	4.84	12.09	4	0	2	2
1x39	7x42	Shared	5.16	5.16	4	0	2	2
2x53	3x32	Shared	4.13	9.28	3	1	2	1
2x60	2x63	ccr8_off	4.51	0	0	1	1	1
2x63	E1x50	Shared	4.82	10.61	0	1	1	2
2x63	E2.Q182	Shared	4.51	4.51	0	1	1	1
2x66	E1x49	Shared	6.53	5.22	0	0	2	1
E1x49	E2.V180	ccr8_off	4.3	0	1	0	1	1
E1x49	E2.L181	Shared	5.32	11.98	1	0	1	1
3x25	E1x50	ccr8_off	3.92	0	6	0	2	2
E1x50	E2.V174	Shared	3.68	3.68	6	0	2	2
E1x50	E2x50	Shared	9.14	15.67	6	0	2	1
3x22	E2.V174	Shared	4.76	4.76	1	0	1	2
3x25	E2x50	Shared	7.28	7.28	6	0	2	1
3x32	3x33	Shared	8.94	12.91	0	1	1	1
3x32	7x42	ccr8_off	5.16	0	0	1	1	2
3x33	4x57	Shared	4.99	3.75	0	1	1	2
3x33	4x61	Shared	8.21	12.89	0	1	1	2
3x33	4x65	Shared	6.95	10.92	0	1	1	2
3x33	5x43	ccr8_off	3.59	0	0	1	1	1
3x36	5x43	Shared	3.73	8.71	0	0	2	1
4x65	E2x52	ccr8_off	7.63	0	0	0	2	2
E2.F186	E2.Q173	ccr8_off	7.03	0	0	1	1	1
E2.A175	E2.F186	Shared	4.16	9.71	0	1	2	1
E2.E177	E2.Q182	Shared	3.82	5.1	1	1	1	1
E2.F186	E2x51	Shared	11.35	4.13	0	1	1	1
E2.Y187	E2x52	ccr8_off	6.36	0	0	0	2	2
5x32	E2.Y187	ccr8_off	3.75	0	0	1	1	2
5x36	E2.Y187	ccr8_off	14.33	0	0	1	2	2
5x31	E2.Q189	ccr8_off	5.12	0	1	0	1	1
5x40	6x55	ccr8_off	12.36	0	0	1	2	1
5x43	6x55	ccr8_off	4.24	0	0	1	1	1
5x44	6x55	ccr8_off	4.12	0	0	0	2	1
7x38	7x42	Shared	8.16	12.83	4	1	1	2
7x28	7x32	ccr8_off	3.38	0	0	0	2	2
6x54	7x34	ccr8_off	3.17	0	0	0	2	1
3x32	6x51	ccr8_off	3.09	0	0	1	1	2
3x22	3x26	Shared	3	1.5	1	0	1	2
5x33	5x36	ccr8_off	2.82	0	0	0	1	2
6x61	7x27	Shared	2.79	6.97	0	0	2	1
7x35	7x39	ccr8_off	2.65	0	0	0	1	2
7x31	7x32	ccr8_off	1.25	0	0	0	1	2
1x25	Lig	ccr8_on	0	16.08	0	0	1	0
2x63	Lig	ccr8_on	0	8.56	0	1	1	0
E2.V180	Lig	ccr8_on	0	6.97	0	1	1	0
2x60	Lig	ccr8_on	0	10.02	0	1	1	0
7x35	Lig	ccr8_on	0	5.56	0	0	1	0
7x38	Lig	ccr8_on	0	8.62	4	1	1	0
3x32	Lig	ccr8_on	0	8.17	0	1	1	0
E2x50	Lig	ccr8_on	0	4.86	6	1	1	0
3x33	Lig	ccr8_on	0	5.64	0	1	1	0
E2x51	Lig	ccr8_on	0	23.86	0	1	1	0
5x43	Lig	ccr8_on	0	4.08	0	1	1	0
6x55	Lig	ccr8_on	0	5.32	0	1	1	0
7x34	Lig	ccr8_on	0	6.18	0	0	1	0
E2.Q182	Lig	ccr8_on	0	9.42	0	1	1	0
E2.F186	Lig	ccr8_on	0	4.08	0	1	1	0
Lig	NT.D26	ccr8_on	0	15.49	1	1	0	1
Lig	NT.P24	ccr8_on	0	27.17	1	1	0	1
Lig	NT.C25	ccr8_on	0	5.59	1	1	0	1
7x24	Lig	ccr8_on	0	6.98	0	1	1	0
7x27	Lig	ccr8_on	0	5.28	0	1	1	0
Lig	NT.S22	ccr8_on	0	13.4	1	1	0	1
Lig	NT.I20	ccr8_on	0	22.62	1	1	0	1
Lig	NT.C21	ccr8_on	0	7.28	1	1	0	1
5x32	Lig	ccr8_on	0	14.07	0	1	1	0
5x33	Lig	ccr8_on	0	7.51	0	0	1	0
6x64	Lig	ccr8_on	0	4.18	0	0	1	0
E3.D270	Lig	ccr8_on	0	4.04	0	0	1	0
NT.C21	NT.S22	ccr8_on	0	5.16	0	1	1	1
7x24	NT.C25	ccr8_on	0	7.28	0	1	1	1
2x53	7x42	ccr8_on	0	7.5	3	1	2	2
4x65	E2x51	ccr8_on	0	4.96	0	0	2	1
E2.A175	E2.E177	ccr8_on	0	4.53	0	1	2	1
E2.L181	E2.S176	ccr8_on	0	4.5	1	0	1	1
E2.E177	E2.F186	ccr8_on	0	7	1	1	1	1
E2.Q182	E2.V180	ccr8_on	0	5.73	0	1	1	1
E2.F186	E2.Q182	ccr8_on	0	7.03	0	1	1	1
E2x51	E2x52	ccr8_on	0	8.9	0	1	1	2
5x36	E2x51	ccr8_on	0	4.78	0	1	2	1
5x35	E2x52	ccr8_on	0	4.94	0	0	2	2
5x32	E2.F186	ccr8_on	0	6.49	0	1	1	1
5x31	E2.N188	ccr8_on	0	5.28	1	0	1	1
5x31	5x35	ccr8_on	0	8.76	1	0	1	2
5x36	5x40	ccr8_on	0	8.39	0	1	2	2
6x51	6x55	ccr8_on	0	14.61	0	0	2	1
5x35	E2.Y187	ccr8_on	0	3.86	0	0	2	2
NT.P24	NT.S23	ccr8_on	0	3.56	0	1	1	2
7x31	Lig	ccr8_on	0	3.17	0	0	1	0
7x23	Lig	ccr8_on	0	3.01	0	0	1	0
E2.G179	E2.S176	ccr8_on	0	1.86	0	1	1	1
1x24	Lig	ccr8_on	0	1.71	0	0	1	0
7x28	NT.C25	ccr8_on	0	1.53	0	0	2	1
3x22	E2.Q173	ccr8_on	0	1.42	1	0	1	1
E2.N188	E2.Q189	ccr8_on	0	1.32	0	0	1	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	ccr8_off	8TLM-CCR8-Anti-murine CCR8 antibody
	ccr8_on	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2

Network Difference
Value	ccr8_off	ccr8_on
I_min	3.59	3.93
Number of Linked Nodes	254	287
Number of Specific Nodes	1 (0.39%)	34 (11.85%)
Number of Shared Nodes	253 (99.61%)	253 (88.15%)
Number of Links	268	327
Number of Specific Links	107 (39.93%)	166 (50.76%)
Number of Shared Links	161 (60.07%)	161 (49.24%)
Number of Hubs	33	34
Number of Specific Hubs	11 (33.33%)	12 (35.29%)
Number of Shared Hubs	22 (66.67%)	22 (64.71%)
Average % Shared Neighbours (Jaccard)	39.68
Average % Shared Neighbours (Otsuka)	49.86
Average % Shared Neighbours (Overlap Coefficient)	61.29
Average % Shared Cliques (k3-6)	77.14
Graphlets Similarity	0.538597

Paths Difference
Value	ccr8_off	ccr8_on
Number Of Nodes in MetaPath	53	63
Specific Nodes in MetaPath	24 (45.28%)	34 (53.97%)
Shared Nodes in MetaPath	253 (99.61%)	253 (99.61%)
Number Of Links MetaPath	54	65
Specific Links in MetaPath	37 (68.52%)	48 (73.85%)
Shared Links in MetaPath	161 (60.07%)	161 (60.07%)
Number of Shortest Paths	47701	59471
Length Of Smallest Path	3	3
Average Path Length	15.3267	12.1414
Length of Longest Path	33	26
Minimum Path Strength	1.4	1.38
Average Path Strength	5.80771	7.04003
Maximum Path Strength	22.59	19.9767
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.972485	0.943307
Maximum Path Correlation	1	0.99
Minimum % Of Corr. Nodes	5.88235	5.55556
Average % Of Corr. Nodes	67.5772	57.6556
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	44.3142	40.9505
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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