psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	Lig	Lig	3014.82	Yes	Yes	1	0	0
2	E1x49	Lig	3.96	Yes	Yes	1	5	0
3	E2.G179	Lig	8.94	No	Yes	0	6	0
4	E2.L181	Lig	5.52	No	Yes	1	4	0
5	E2.S176	Lig	6.26	No	Yes	0	3	0
6	E2.D178	Lig	25.38	No	Yes	0	1	0
7	E2.E177	Lig	9.81	No	Yes	1	1	0
8	E2.Q173	Lig	19.8	No	Yes	1	4	0
9	3x22	Lig	10.12	No	Yes	1	4	0
10	E2.N188	Lig	8.39	No	Yes	0	5	0
11	5x31	Lig	7.89	No	Yes	1	4	0
12	E2.Q189	Lig	11.09	No	Yes	1	3	0
13	1x32	2x64	5.64	No	No	0	4	5
14	1x35	1x39	15.24	No	Yes	0	5	7
15	1x35	2x64	5.54	No	No	0	5	5
16	1x38	1x42	6.09	No	No	0	5	6
17	1x39	2x60	5.64	Yes	No	0	7	5
18	1x39	7x38	4.49	Yes	No	4	7	5
19	1x39	7x39	4.84	Yes	No	0	7	4
20	1x39	7x42	5.16	Yes	Yes	4	7	7
21	1x42	2x57	3.65	No	Yes	0	6	7
22	1x43	1x47	3.65	Yes	No	5	6	6
23	1x43	2x54	3.93	Yes	Yes	5	6	5
24	1x43	2x57	9.65	Yes	Yes	0	6	7
25	1x43	2x58	4.33	Yes	No	0	6	9
26	1x44	1x45	3.93	No	No	0	5	5
27	1x46	1x50	4.47	No	Yes	0	8	9
28	1x46	2x54	4.85	No	Yes	0	8	5
29	1x46	7x46	5.16	No	Yes	0	8	8
30	1x47	2x54	4.47	No	Yes	5	6	5
31	1x49	7x50	4.06	No	No	0	7	9
32	1x50	2x50	12.12	Yes	Yes	0	9	9
33	1x50	2x51	5.49	Yes	No	0	9	7
34	1x50	7x50	6.52	Yes	No	0	9	9
35	1x56	8x53	4.15	No	Yes	0	7	5
36	1x57	8x50	3.65	No	Yes	0	6	8
37	1x60	8x53	17.69	No	Yes	0	5	5
38	8x49	I1x48	7.18	No	No	0	6	6
39	8x53	I1x48	7.86	Yes	No	0	5	6
40	I1x49	I1x51	4.95	No	No	0	6	7
41	2x44	I1x50	4.15	No	No	0	5	6
42	2x37	2x40	7.36	No	No	0	7	8
43	2x38	2x42	7.25	No	Yes	0	6	6
44	2x38	I2x57	3.76	No	Yes	0	6	7
45	2x40	8x49	8.3	No	No	0	8	6
46	2x42	3x45	4.69	Yes	No	0	6	5
47	2x42	3x46	3.59	Yes	No	0	6	9
48	2x43	7x53	8.21	No	Yes	0	8	9
49	2x45	3x42	12.08	No	Yes	2	9	7
50	2x45	4x46	9.45	No	No	2	9	7
51	2x45	4x50	5.65	No	Yes	2	9	9
52	2x46	7x49	5.49	No	No	0	9	9
53	2x49	3x38	6.52	No	No	2	8	6
54	2x49	4x50	6.18	No	Yes	2	8	9
55	2x50	7x45	3.78	Yes	Yes	3	9	9
56	2x50	7x46	6.22	Yes	Yes	3	9	8
57	2x50	7x49	4.04	Yes	No	0	9	9
58	2x53	3x32	4.13	Yes	Yes	0	6	6
59	2x53	3x35	4.52	Yes	No	0	6	8
60	2x53	6x48	4.01	Yes	Yes	3	6	8
61	2x53	7x45	11.31	Yes	Yes	3	6	9
62	2x53	7x46	4.19	Yes	Yes	3	6	8
63	2x57	7x42	9.65	Yes	Yes	0	7	7
64	2x59	E1x52	10.72	No	Yes	0	6	7
65	2x59	3x28	6.55	No	No	0	6	4
66	2x60	2x63	4.51	No	No	0	5	5
67	2x62	E1x52	5.16	No	Yes	0	4	7
68	2x63	E1x50	4.82	No	Yes	0	5	8
69	2x63	E2.Q182	4.51	No	No	0	5	2
70	2x66	E1x49	6.53	No	Yes	0	5	5
71	E1x49	E2.V180	4.3	Yes	No	0	5	4
72	E1x49	E2.L181	5.32	Yes	No	1	5	4
73	E1x50	E1x52	16.04	Yes	Yes	0	8	7
74	3x25	E1x50	3.92	No	Yes	6	9	8
75	E1x50	E2.V174	3.68	Yes	No	0	8	4
76	E1x50	E2x50	9.14	Yes	No	6	8	9
77	E1x51	E1x52	3.93	No	Yes	0	3	7
78	3x22	E2.V174	4.76	No	No	0	4	4
79	3x25	E2x50	7.28	No	No	6	9	9
80	3x27	3x31	5.24	No	No	0	5	6
81	3x29	4x65	13.99	No	No	0	6	4
82	3x30	4x62	5.13	No	No	0	5	4
83	3x32	3x33	8.94	Yes	Yes	0	6	3
84	3x32	7x42	5.16	Yes	Yes	0	6	7
85	3x33	4x57	4.99	Yes	No	0	3	6
86	3x33	4x61	8.21	Yes	No	0	3	4
87	3x33	4x65	6.95	Yes	No	0	3	4
88	3x33	5x43	3.59	Yes	No	0	3	4
89	3x34	4x57	6.08	No	No	0	4	6
90	3x36	3x37	10.32	No	Yes	0	7	6
91	3x36	5x43	3.73	No	No	0	7	4
92	3x36	6x48	20.04	No	Yes	0	7	8
93	3x37	3x41	4.13	Yes	Yes	0	6	4
94	3x37	5x42	4.78	Yes	No	0	6	2
95	3x38	4x50	9.88	No	Yes	2	6	9
96	3x39	7x45	5.58	No	Yes	0	9	9
97	3x40	5x50	6.71	No	Yes	0	7	9
98	3x41	4x49	3.93	Yes	No	0	4	6
99	3x41	5x46	4.87	Yes	No	0	4	5
100	3x42	4x46	4.19	Yes	No	2	7	7
101	3x42	4x49	10.49	Yes	No	0	7	6
102	3x42	4x50	6.01	Yes	Yes	2	7	9
103	3x43	5x54	5.02	No	Yes	0	8	7
104	3x43	6x40	4.61	No	No	0	8	7
105	3x44	5x54	3.89	No	Yes	0	7	7
106	3x45	4x49	4.47	No	No	0	5	6
107	3x46	7x53	4.79	No	Yes	0	9	9
108	3x47	5x54	7.93	No	Yes	0	9	7
109	3x47	5x58	8.9	No	Yes	0	9	8
110	3x49	I2x57	17.87	No	Yes	0	8	7
111	3x50	6x34	7.52	No	No	0	9	6
112	3x50	6x37	5.23	No	No	0	9	7
113	3x51	3x55	13.88	Yes	No	7	8	7
114	3x51	3x56	7.62	Yes	No	7	8	5
115	3x51	5x56	7.22	Yes	No	0	8	4
116	3x51	5x57	8.06	Yes	No	0	8	7
117	3x51	5x60	4.78	Yes	No	0	8	3
118	3x51	5x61	4.84	Yes	No	0	8	8
119	3x53	I2x57	4.15	No	Yes	0	8	7
120	3x54	5x61	7.68	No	No	0	8	8
121	3x55	3x56	5.54	No	No	7	7	5
122	I2x52	I2x56	5.05	No	No	0	5	5
123	4x57	4x62	4.42	No	No	0	6	4
124	4x61	5x39	7.37	No	No	0	4	5
125	4x63	4x64	7.87	No	No	0	5	5
126	4x64	E2.Y187	17.54	No	Yes	0	5	5
127	4x64	5x35	4.01	No	No	0	5	2
128	4x65	E2x52	7.63	No	No	0	4	4
129	E2.F186	E2.Q173	7.03	No	No	0	5	4
130	E2.A175	E2.F186	4.16	No	No	0	2	5
131	E2.E177	E2.Q182	3.82	No	No	0	1	2
132	E2.F186	E2x51	11.35	No	No	0	5	2
133	E2.Y187	E2x52	6.36	Yes	No	0	5	4
134	5x32	E2.Y187	3.75	No	Yes	0	3	5
135	5x36	E2.Y187	14.33	No	Yes	0	3	5
136	5x31	E2.Q189	5.12	No	No	1	4	3
137	5x34	5x35	9.28	No	No	0	1	2
138	5x35	5x38	4.01	No	No	0	2	3
139	5x38	5x42	3.72	No	No	0	3	2
140	5x40	6x55	12.36	No	No	0	4	5
141	5x40	6x59	4.47	No	No	0	4	4
142	5x41	5x45	3.77	No	No	0	4	4
143	5x41	6x59	10.57	No	No	0	4	4
144	5x43	6x55	4.24	No	No	0	4	5
145	5x44	6x55	4.12	No	No	0	5	5
146	5x44	6x56	3.62	No	No	0	5	5
147	5x45	5x48	4.28	No	No	0	4	5
148	5x461	5x50	4.06	No	Yes	0	5	9
149	5x47	6x52	13.73	No	No	0	8	8
150	5x49	5x50	5.08	No	Yes	0	6	9
151	5x51	6x45	3.65	No	No	0	6	5
152	5x54	6x41	13.11	Yes	No	0	7	7
153	5x54	6x45	6.09	Yes	No	0	7	5
154	5x58	6x37	3.79	Yes	No	0	8	7
155	5x58	6x41	10.09	Yes	No	0	8	7
156	5x62	5x66	4.23	No	No	0	5	5
157	5x63	5x67	9.03	No	No	0	4	5
158	6x36	7x53	5.86	No	Yes	0	7	9
159	6x36	7x56	7.45	No	No	0	7	5
160	6x40	7x53	5.05	No	Yes	0	7	9
161	6x46	6x47	6.09	No	No	0	5	7
162	6x47	7x45	4.53	No	Yes	0	7	9
163	6x48	7x41	9.88	Yes	No	0	8	7
164	6x48	7x45	10.58	Yes	Yes	3	8	9
165	6x49	6x50	5.3	No	No	0	5	9
166	6x50	7x37	5.25	No	No	0	9	7
167	6x54	7x37	4.76	No	No	0	4	7
168	6x56	6x60	12.18	No	No	0	5	3
169	6x61	7x26	10.61	No	No	0	1	2
170	7x26	7x29	4.12	No	No	0	2	4
171	7x26	7x30	4.28	No	No	0	2	4
172	7x28	7x29	16.64	No	No	0	4	4
173	7x38	7x42	8.16	No	Yes	4	5	7
174	7x45	7x46	4.42	Yes	Yes	3	9	8
175	7x53	8x50	5.16	Yes	Yes	0	9	8
176	8x49	8x50	11.17	No	Yes	0	6	8
177	8x52	8x53	11.79	No	Yes	0	6	5
178	8x56	8x57	8.2	No	No	0	4	5
179	1x53	7x50	3.53	No	No	0	8	9
180	3x44	5x50	3.5	No	Yes	0	7	9
181	2x52	3x35	3.42	No	No	0	7	8
182	4x59	4x60	3.39	No	No	0	4	8
183	7x28	7x32	3.38	No	No	0	4	3
184	1x54	2x47	3.25	Yes	No	0	7	8
185	6x54	7x34	3.17	No	No	0	4	4
186	1x36	2x64	3.15	No	No	0	5	5
187	3x43	6x44	3.1	No	No	0	8	9
188	3x32	6x51	3.09	Yes	No	0	6	6
189	6x40	7x52	3.07	No	No	0	7	8
190	7x36	7x40	3.07	No	No	0	5	7
191	7x48	7x52	3.07	No	No	0	7	8
192	3x24	3x27	3.04	No	No	0	5	5
193	3x44	5x53	3.04	No	No	0	7	6
194	4x41	I2x56	3.04	Yes	No	0	4	5
195	4x38	4x41	3.01	No	Yes	0	7	4
196	3x22	3x26	3	No	No	0	4	7
197	1x55	1x59	2.98	No	No	0	4	4
198	2x41	I1x50	2.98	No	No	0	6	6
199	3x52	I2x56	2.98	No	No	0	5	5
200	5x55	5x59	2.92	No	No	0	4	5
201	5x59	5x60	2.91	No	No	0	5	3
202	2x42	4x42	2.9	Yes	No	0	6	7
203	3x54	5x64	2.87	No	No	0	8	6
204	1x54	2x44	2.85	Yes	No	0	7	5
205	1x54	2x51	2.85	Yes	No	0	7	7
206	6x38	6x42	2.85	No	No	0	4	5
207	5x33	5x36	2.82	No	No	0	1	3
208	6x61	7x27	2.79	No	No	0	1	5
209	I2x53	I2x57	2.77	No	Yes	0	5	7
210	6x43	6x47	2.77	No	No	0	6	7
211	6x57	7x30	2.77	No	No	0	5	4
212	5x44	6x52	2.72	No	No	0	5	8
213	5x57	5x58	2.69	No	Yes	0	7	8
214	3x37	4x56	2.67	Yes	No	0	6	4
215	7x35	7x39	2.65	No	No	0	4	4
216	2x56	2x57	2.64	No	Yes	0	6	7
217	3x41	4x52	2.59	Yes	No	0	4	4
218	6x51	7x37	2.59	No	No	0	6	7
219	5x37	5x41	2.51	No	No	0	3	4
220	1x39	2x61	2.5	Yes	No	0	7	7
221	3x24	E1x52	2.49	No	Yes	0	5	7
222	5x66	5x67	2.48	No	No	0	5	5
223	1x41	1x45	2.44	No	No	0	5	5
224	5x58	6x38	2.34	Yes	No	0	8	4
225	3x21	E2.V174	1.84	No	No	0	7	4
226	7x56	8x47	1.84	No	No	0	5	8
227	7x46	7x47	1.82	Yes	No	0	8	6
228	4x41	4x42	1.75	Yes	No	0	4	7
229	1x48	1x49	1.71	No	No	0	5	7
230	1x59	1x60	1.71	No	No	0	4	5
231	3x38	4x53	1.71	No	No	0	6	7
232	1x30	1x31	1.7	No	No	0	4	1
233	6x54	7x33	1.7	No	No	0	4	5
234	1x40	2x61	1.69	No	No	0	6	7
235	6x50	7x40	1.69	No	No	0	9	7
236	7x43	7x47	1.69	No	No	0	5	6
237	4x60	5x42	1.67	No	No	0	8	2
238	3x23	3x27	1.6	No	No	0	1	5
239	6x49	6x53	1.6	No	No	0	5	6
240	7x48	7x51	1.6	No	No	0	7	5
241	1x36	2x65	1.58	No	No	0	5	4
242	7x54	8x54	1.58	No	No	0	6	6
243	1x54	1x58	1.54	Yes	No	0	7	4
244	3x48	5x53	1.54	No	No	0	6	6
245	2x38	2x39	1.52	No	No	0	6	7
246	4x38	4x39	1.52	No	No	0	7	3
247	4x41	4x44	1.51	Yes	No	0	4	3
248	1x33	1x37	1.49	No	No	0	4	5
249	1x37	1x41	1.49	No	No	0	5	5
250	6x53	6x57	1.49	No	No	0	6	5
251	3x34	4x54	1.47	No	No	0	4	3
252	4x43	4x47	1.47	No	No	0	3	4
253	4x44	4x45	1.47	No	No	0	3	5
254	4x54	4x59	1.47	No	No	0	3	4
255	6x39	6x42	1.47	No	No	0	5	5
256	7x25	7x29	1.44	No	No	0	3	4
257	1x54	2x48	1.43	Yes	No	0	7	6
258	5x65	6x34	1.43	No	No	0	8	6
259	1x45	7x47	1.4	No	No	0	5	6
260	1x52	1x55	1.38	No	No	0	6	4
261	8x48	8x51	1.35	No	No	0	5	8
262	2x54	2x55	1.31	Yes	No	0	5	4
263	7x55	7x56	1.31	No	No	0	7	5
264	4x38	4x40	1.29	No	No	0	7	4
265	7x31	7x32	1.25	No	No	0	4	3
266	I1x48	I1x51	1.24	No	No	0	6	7
267	8x50	8x54	1.22	Yes	No	0	8	6
268	I2x52	I2x55	1.19	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg. Int. Strength	Num. Of Links	Community	ConSurf
1	Lig	472.831	13	1	0
2	1x39	6.31167	6	4	7
3	1x43	5.39	4	5	6
4	1x50	7.15	4	0	9
5	1x54	2.384	5	0	7
6	2x42	4.6075	4	0	6
7	2x50	6.54	4	3	9
8	2x53	5.632	5	3	6
9	2x54	3.64	4	5	5
10	2x57	6.3975	4	0	7
11	E1x49	5.0275	4	1	5
12	E1x50	7.52	5	6	8
13	E1x52	7.668	5	0	7
14	3x32	5.33	4	0	6
15	3x33	6.536	5	0	3
16	3x37	5.475	4	0	6
17	3x41	3.88	4	0	4
18	3x42	8.1925	4	2	7
19	3x51	7.73333	6	7	8
20	I2x57	7.1375	4	0	7
21	4x41	2.3275	4	0	4
22	4x50	6.93	4	2	9
23	E2.Y187	10.495	4	0	5
24	5x50	4.8375	4	0	9
25	5x54	7.208	5	0	7
26	5x58	5.562	5	0	8
27	6x48	11.1275	4	3	8
28	7x42	7.0325	4	4	7
29	7x45	6.7	6	3	9
30	7x46	4.362	5	3	8
31	7x53	5.814	5	0	9
32	8x50	5.3	4	0	8
33	8x53	10.3725	4	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	1x39	2x60	50.7515	5.64	Yes	No	0	7	5
2	2x60	2x63	49.4289	4.51	No	No	0	5	5
3	2x63	E2.Q182	24.8704	4.51	No	No	0	5	2
4	E2.E177	E2.Q182	23.4275	3.82	No	No	0	1	2
5	E2.E177	Lig	21.9659	9.81	No	Yes	1	1	0
6	2x57	7x42	11.5165	9.65	Yes	Yes	0	7	7
7	1x39	7x42	63.3952	5.16	Yes	Yes	4	7	7
8	7x46	7x47	11.0168	1.82	Yes	No	0	8	6
9	2x53	7x46	20.523	4.19	Yes	Yes	3	6	8
10	2x53	3x32	54.073	4.13	Yes	Yes	0	6	6
11	3x32	7x42	69.4146	5.16	Yes	Yes	0	6	7
12	1x46	7x46	11.7382	5.16	No	Yes	0	8	8
13	1x50	2x50	16.1306	12.12	Yes	Yes	0	9	9
14	2x50	7x45	13.7897	3.78	Yes	Yes	3	9	9
15	1x50	2x51	14.6051	5.49	Yes	No	0	9	7
16	8x49	I1x48	12.8466	7.18	No	No	0	6	6
17	8x49	8x50	16.5552	11.17	No	Yes	0	6	8
18	7x53	8x50	21.3948	5.16	Yes	Yes	0	9	8
19	3x46	7x53	81.0137	4.79	No	Yes	0	9	9
20	2x42	3x46	81.7389	3.59	Yes	No	0	6	9
21	2x42	3x45	93.5072	4.69	Yes	No	0	6	5
22	3x45	4x49	94.0896	4.47	No	No	0	5	6
23	3x41	4x49	98.4782	3.93	Yes	No	0	4	6
24	3x37	3x41	100	4.13	Yes	Yes	0	6	4
25	3x36	3x37	98.497	10.32	No	Yes	0	7	6
26	3x36	5x43	44.8486	3.73	No	No	0	7	4
27	3x33	5x43	42.0042	3.59	Yes	No	0	3	4
28	3x32	3x33	46.979	8.94	Yes	Yes	0	6	3
29	3x36	6x48	58.9577	20.04	No	Yes	0	7	8
30	2x53	6x48	41.2903	4.01	Yes	Yes	3	6	8
31	1x54	2x51	12.8053	2.85	Yes	No	0	7	7
32	E1x50	E1x52	13.9288	16.04	Yes	Yes	0	8	7
33	3x43	5x54	56.7333	5.02	No	Yes	0	8	7
34	3x43	6x40	58.612	4.61	No	No	0	8	7
35	6x40	7x53	62.2793	5.05	No	Yes	0	7	9
36	3x47	5x54	23.4463	7.93	No	Yes	0	9	7
37	3x47	5x58	22.3454	8.9	No	Yes	0	9	8
38	5x58	6x41	22.3454	10.09	Yes	No	0	8	7
39	5x54	6x41	23.4463	13.11	Yes	No	0	7	7
40	3x51	5x57	23.8559	8.06	Yes	No	0	8	7
41	5x57	5x58	26.2005	2.69	No	Yes	0	7	8
42	4x41	4x42	12.8466	1.75	Yes	No	0	4	7
43	2x42	4x42	14.0903	2.9	Yes	No	0	6	7
44	5x43	6x55	12.4859	4.24	No	No	0	4	5
45	6x49	6x50	17.8966	5.3	No	No	0	5	9
46	6x50	7x37	22.2026	5.25	No	No	0	9	7
47	6x51	7x37	27.8387	2.59	No	No	0	6	7
48	3x32	6x51	29.2064	3.09	Yes	No	0	6	6
49	7x26	7x30	12.05	4.28	No	No	0	2	4
50	6x57	7x30	13.523	2.77	No	No	0	5	4
51	6x53	6x57	14.9884	1.49	No	No	0	6	5
52	6x49	6x53	16.4462	1.6	No	No	0	5	6
53	2x63	E1x50	23.42	4.82	No	Yes	0	5	8
54	6x48	7x45	17.5922	10.58	Yes	Yes	3	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E1x49	Lig	3.96	1	Yes	Yes	5	0	1	0
E2.G179	Lig	8.94	0	No	Yes	6	0	1	0
E2.L181	Lig	5.52	1	No	Yes	4	0	1	0
E2.S176	Lig	6.26	0	No	Yes	3	0	1	0
E2.D178	Lig	25.38	0	No	Yes	1	0	1	0
E2.E177	Lig	9.81	1	No	Yes	1	0	1	0
E2.Q173	Lig	19.8	1	No	Yes	4	0	1	0
3x22	Lig	10.12	1	No	Yes	4	0	1	0
E2.N188	Lig	8.39	0	No	Yes	5	0	1	0
5x31	Lig	7.89	1	No	Yes	4	0	1	0
E2.Q189	Lig	11.09	1	No	Yes	3	0	1	0
2x66	E1x49	6.53	0	No	Yes	5	5	2	1
E1x49	E2.V180	4.3	1	Yes	No	5	4	1	2
E1x49	E2.L181	5.32	1	Yes	No	5	4	1	1
3x22	E2.V174	4.76	1	No	No	4	4	1	2
E2.F186	E2.Q173	7.03	0	No	No	5	4	2	1
E2.E177	E2.Q182	3.82	1	No	No	1	2	1	2
5x31	E2.Q189	5.12	1	No	No	4	3	1	1
3x22	3x26	3	1	No	No	4	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	8TLM	Anti-murine CCR8 antibody	8TLM-CCR8-Anti-murine CCR8 antibody
20.00	Single	8W8S	AA-14	8W8S-GPR101-AA-14
16.67	Single	8W8R	AA-14	8W8R-GPR101-AA-14-chim(NtGi1-Gs)/&β;1/&γ;2
15.00	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
14.29	Single	8WCB	Cyclohexylammonium ion	8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29	Single	8WCC	Cyclohexylammonium ion	8WCC-TA1-Cyclohexylammonium ion
13.33	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
12.50	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50	Single	7XKE	Betahydroxyandrosterone	7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
12.50	Single	8HQM	NPGLY	8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
12.50	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
12.50	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
11.76	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
11.76	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76	Consensus	gs_galanin	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
11.11	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
11.11	Single	7VDM	Substance P	7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
11.11	Single	7XKD	Betahydroxyandrosterone	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
11.11	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
11.11	Single	8HVI	NOX-6-7	8HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
11.11	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
11.11	Consensus	hca2_on_allo	Orthosteric Ligand	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
10.53	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
10.00	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
10.00	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
10.00	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
10.00	Single	5WKT	Octyl Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
10.00	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
10.00	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
10.00	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
10.00	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
10.00	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
10.00	Single	6OIK	LY2119620	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.00	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
10.00	Single	7MT8	All-trans-retinal	7MT8-Rhodopsin-All-trans-retinal-GRK1
10.00	Single	7MT9	All-trans-retinal	7MT9-Rhodopsin-All-trans-retinal-GRK1
10.00	Single	7MTA	All-trans-retinal	7MTA-Rhodopsin-All-trans-retinal-GRK1
10.00	Single	7S8O	(R)-Zinc-3573	7S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
10.00	Single	8F76	-	8F76-OR51E2-Gs/&β;1/&γ;2
10.00	Single	8J6Q	Beta-hydroxybutyrate	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
10.00	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off alpha1b_off
10.00	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
10.00	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
9.09	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
9.09	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
9.09	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
9.09	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
9.09	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
9.09	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
9.09	Single	6QNO	All-trans-retinal	6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
9.09	Single	6U1N	LY2119620	6U1N-M₂-LY2119620-Arrestin2
9.09	Single	7S8N	(R)-Zinc-3573	7S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
9.09	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
9.09	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
9.09	Single	7XKF	Betahydroxyandrosterone	7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
9.09	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/&β;1/&γ;2
9.09	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2
9.09	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
9.09	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2
9.09	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2
9.09	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/&β;1/&γ;2
9.09	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/&β;1/&γ;2
9.09	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/&β;1/&γ;2
9.09	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
9.09	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
9.09	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
9.09	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
9.09	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
9.09	Consensus	go_protein	Orthosteric Ligand	go_chemokine
9.09	Consensus	mt1_on	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
9.09	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.33	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
8.33	Single	2X72	All-trans-retinal	2X72-Rhodopsin-All-trans-retinal-Gt(CT)
8.33	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
8.33	Single	3PWH	ZM241385	3PWH-A_2A-ZM241385
8.33	Single	3VG9	ZM241385	3VG9-A_2A-ZM241385-Antibody
8.33	Single	3VGA	ZM241385	3VGA-A_2A-ZM241385-Antibody
8.33	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
8.33	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
8.33	Single	5K2D	ZM241385	5K2D-A_2A-ZM241385
8.33	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
8.33	Single	5U09	Taranabant	5U09-CB₁-Taranabant
8.33	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
8.33	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/&β;1/&γ;2
8.33	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
8.33	Single	6JZH	ZM241385	6JZH-A_2A-ZM241385-Na
8.33	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
8.33	Single	6NWE	Octyl Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
8.33	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
8.33	Single	6OYA	All-trans-retinal	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
8.33	Single	6PS7	ZM241385	6PS7-A_2A-ZM241385-Na
8.33	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
8.33	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
8.33	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
8.33	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
8.33	Single	7T94	PubChem 57664406	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
8.33	Single	7TUZ	7alpha,25-dihydroxycholesterol	7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
8.33	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
8.33	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
8.33	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
8.33	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
8.33	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
8.33	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
8.33	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
8.33	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
8.33	Single	8DWH	Compound-16	8DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
8.33	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
8.33	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2
8.33	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
8.33	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2
8.33	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/&β;1/&γ;2
8.33	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33	Single	8U8F	PML	8U8F-GPR3-PML-Gs/&β;1/&γ;2
8.33	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
8.33	Consensus	a2a_off_allo	Orthosteric Ligand	6ZDR-A_2A-HMS1413f12-Na 6GT3-A_2A-Imaradenant-Na 8CU7-A_2A-LJ-4517-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PubChem 92460631; psb36-Na 5MZJ-A_2A-Theophylline-Na 5OLO-A_2A-Tozadenant-Na 5OLH-A_2A-Vipadenant-Na 5NM4-A_2A-ZM241385-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5MZP-A_2A-Caffeine-Na 8CIC-A_2A-Etrumadenant-Na
8.33	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
8.33	Consensus	class-f_off	Orthosteric Ligand	smo_off
8.33	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
8.33	Consensus	gi_neuromedin	Orthosteric Ligand	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
8.33	Consensus	gi_nucleotide	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
8.33	Consensus	gt_class-a	Orthosteric Ligand	gt_opsin
8.33	Consensus	gt_opsin	Orthosteric Ligand	gt_sensory
8.33	Consensus	gt_sensory	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
8.33	Consensus	m2_on_allo	Other Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
8.33	Consensus	melatonin_on	Orthosteric Ligand	mt1_on mt2_on
8.33	Consensus	mglu_on	Other Ligand	mglu2_on mglu4_on
8.33	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
8.33	Consensus	smo_on_allo	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.00	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
7.69	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
7.69	Single	5IU4	ZM241385	5IU4-A_2A-ZM241385-Na
7.69	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
7.69	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
7.69	Single	5JTB	ZM241385	5JTB-A_2A-ZM241385
7.69	Single	5K2B	ZM241385	5K2B-A_2A-ZM241385-Na
7.69	Single	5K2C	ZM241385	5K2C-A_2A-ZM241385-Na
7.69	Single	5NLX	ZM241385	5NLX-A_2A-ZM241385-Na
7.69	Single	5NM4	ZM241385	5NM4-A_2A-ZM241385-Na
7.69	Single	5TE3	Octyl Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
7.69	Single	5UVI	ZM241385	5UVI-A_2A-ZM241385
7.69	Single	6AQF	ZM241385	6AQF-A_2A-ZM241385
7.69	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
7.69	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
7.69	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
7.69	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
7.69	Single	6MH8	ZM241385	6MH8-A_2A-ZM241385
7.69	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
7.69	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
7.69	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
7.69	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
7.69	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
7.69	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
7.69	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/&β;1/&γ;2
7.69	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
7.69	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2
7.69	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
7.69	Single	7F61	PF-03654746	7F61-H₃-PF-03654746-Cholesterol
7.69	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/&β;1/&γ;2
7.69	Single	7T32	ZM241385	7T32-A_2A-ZM241385
7.69	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
7.69	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
7.69	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
7.69	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
7.69	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
7.69	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
7.69	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
7.69	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
7.69	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
7.69	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2
7.69	Single	8GUR	PubChem 104895	8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2
7.69	Single	8HQN	9(S)-HODE	8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
7.69	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
7.69	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/&β;1/&γ;2
7.69	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/&β;1/&γ;2
7.69	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2
7.69	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
7.69	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/&β;1/&γ;2
7.69	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
7.69	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/&β;1/&γ;2
7.69	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2
7.69	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
7.69	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
7.69	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
7.69	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
7.69	Consensus	d1_on_allo	Orthosteric Ligand	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
7.69	Consensus	ffa2_on	Orthosteric Ligand	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
7.69	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
7.69	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
7.69	Consensus	gi_melatonin	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
7.69	Consensus	go_galanin	Orthosteric Ligand	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
7.69	Consensus	gs_tar	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Consensus	h3_on_allo	Orthosteric Ligand	7F61-H₃-PF-03654746-Cholesterol
7.69	Consensus	hca_on	Orthosteric Ligand	hca2_on hca3_on
7.69	Consensus	hcar_on	Orthosteric Ligand	hca_on
7.69	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Consensus	m1_off_allo	Other Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
7.69	Consensus	sensory_off	Orthosteric Ligand	opsin_off
7.14	Single	3EML	ZM241385	3EML-A_2A-ZM241385
7.14	Single	4EIY	ZM241385	4EIY-A_2A-ZM241385-Na
7.14	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
7.14	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
7.14	Single	4X1H	Nonyl Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
7.14	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
7.14	Single	5K2A	ZM241385	5K2A-A_2A-ZM241385-Na
7.14	Single	5OLG	ZM241385	5OLG-A_2A-ZM241385-Na
7.14	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
7.14	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
7.14	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
7.14	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
7.14	Single	5UEN	DU172	5UEN-A₁-DU172
7.14	Single	5VRA	ZM241385	5VRA-A_2A-ZM241385-Na
7.14	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
7.14	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
7.14	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
7.14	Single	6IIV	Daltroban	6IIV-TP-Daltroban
7.14	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2
7.14	Single	6LPJ	ZM241385	6LPJ-A_2A-ZM241385-Na
7.14	Single	6LPK	ZM241385	6LPK-A_2A-ZM241385-Na
7.14	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
7.14	Single	6S0L	ZM241385	6S0L-A_2A-ZM241385
7.14	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
7.14	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
7.14	Single	7CFM	P395	7CFM-GPBA-P395-Gs/&β;1/&γ;2
7.14	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/&β;1/&γ;2
7.14	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
7.14	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.14	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
7.14	Single	7LJC	PubChem 86764103	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
7.14	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
7.14	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
7.14	Single	7V3Z	PubMed 104895	7V3Z-CB₁-PubMed 104895
7.14	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/&β;1/&γ;2
7.14	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
7.14	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
7.14	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
7.14	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
7.14	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
7.14	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
7.14	Single	8EJC	TAK-875	8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8EJK	TAK-875	8EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
7.14	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/&β;1/&γ;2
7.14	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
7.14	Single	8J18	(3R)-3-hydroxydodecanoic acid	8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
7.14	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
7.14	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
7.14	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
7.14	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
7.14	Single	8X17	Namodenoson	8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
7.14	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
7.14	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
7.14	Consensus	a2_off	Orthosteric Ligand	a2a_off
7.14	Consensus	a2a_off	Orthosteric Ligand	8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 5UIG-A_2A-J3.651.884G 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-PubChem 168451710 5K2D-A_2A-ZM241385
7.14	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on
7.14	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
7.14	Consensus	cb1_on_allo	Orthosteric Ligand	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
7.14	Consensus	ffa_on	Orthosteric Ligand	ffa4_on ffa1_on ffa2_on ffa3_on
7.14	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.14	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
7.14	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
7.14	Consensus	gi_hca	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
7.14	Consensus	gi_hcar	Orthosteric Ligand	gi_hca
7.14	Consensus	hca2_on	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
7.14	Consensus	hca3_on	Orthosteric Ligand	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
7.14	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
7.14	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
7.14	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
7.14	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on
7.14	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
7.14	Consensus	prostanoid_off	Orthosteric Ligand	ep_off tp_off dp_off
7.14	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
7.14	Consensus	tar_on	Orthosteric Ligand	ta1_on
7.14	Consensus	tp_off	Orthosteric Ligand	6IIV-TP-Daltroban 6IIU-TP-Ramatroban
6.90	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
6.67	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
6.67	Single	4PHU	Fasiglifam	4PHU-FFA1 (GPR40)-Fasiglifam
6.67	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
6.67	Single	5N2R	PubChem 92460631; psb36	5N2R-A_2A-PubChem 92460631; psb36-Na
6.67	Single	5N2S	PSB36	5N2S-A₁-PSB36
6.67	Single	5NM2	ZM241385	5NM2-A_2A-ZM241385-Na
6.67	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
6.67	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
6.67	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
6.67	Single	5ZK3	Quinuclidinyl benzilate hydrobromide	5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
6.67	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
6.67	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
6.67	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
6.67	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
6.67	Single	6LPL	ZM241385	6LPL-A_2A-ZM241385-Na
6.67	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
6.67	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
6.67	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
6.67	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
6.67	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
6.67	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
6.67	Single	6S0Q	ZM241385	6S0Q-A_2A-ZM241385
6.67	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
6.67	Single	6WQA	ZM241385	6WQA-A_2A-ZM241385-Na
6.67	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
6.67	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
6.67	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2
6.67	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/&β;1/&γ;2
6.67	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
6.67	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
6.67	Single	7RM5	ZM241385	7RM5-A_2A-ZM241385-Na
6.67	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
6.67	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
6.67	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
6.67	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
6.67	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
6.67	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7Y27	Somatostatin-14	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.67	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.67	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.67	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
6.67	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
6.67	Single	8FYN	ZM241385	8FYN-A_2A-ZM241385-Na
6.67	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2
6.67	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/&β;1/&γ;2
6.67	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
6.67	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
6.67	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
6.67	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
6.67	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
6.67	Single	8J19	PubChem 127045422	8J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
6.67	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
6.67	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
6.67	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
6.67	Single	8QOT	Nanobody E	8QOT-μ-Nanobody E
6.67	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
6.67	Consensus	a1_on_allo	Orthosteric Ligand	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
6.67	Consensus	a2a_on	Orthosteric Ligand	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
6.67	Consensus	adrenergic_off	Orthosteric Ligand	beta_off alpha_off
6.67	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
6.67	Consensus	cb2_on	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
6.67	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
6.67	Consensus	ep3_on	Orthosteric Ligand	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
6.67	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
6.67	Consensus	ep_off	Orthosteric Ligand	ep4_off
6.67	Consensus	gs_adrenergic	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJI-β₃-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
6.67	Consensus	gs_sst	Orthosteric Ligand	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
6.67	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	2YDV	NECA	2YDV-A_2A-NECA
6.25	Single	3UON	Quinuclidinyl benzilate hydrobromide	3UON-M₂-Quinuclidinyl benzilate hydrobromide
6.25	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
6.25	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
6.25	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
6.25	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
6.25	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
6.25	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
6.25	Single	5G53	NECA	5G53-A_2A-NECA-Gs
6.25	Single	5TZR	-	5TZR-FFA1 (GPR40)-MK8666
6.25	Single	5V56	TC114	5V56-SMO-TC114
6.25	Single	5V57	TC114	5V57-SMO-TC114
6.25	Single	5XR8	AM841	5XR8-CB₁-AM841
6.25	Single	5XRA	AM11542	5XRA-CB₁-AM11542
6.25	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
6.25	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
6.25	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
6.25	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
6.25	Single	6OS1	TRV026	6OS1-AT₁-TRV026
6.25	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
6.25	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
6.25	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/&β;1/&γ;2
6.25	Single	7EW7	PubChem 4077460	7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
6.25	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
6.25	Single	7FEE	PubMed 104895	7FEE-CB₁-PubMed 104895-ZCZ011
6.25	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/&β;1/&γ;2
6.25	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/&β;1/&γ;2
6.25	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
6.25	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
6.25	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
6.25	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
6.25	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
6.25	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
6.25	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2
6.25	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
6.25	Single	7W41	PD176252	7W41-BB₂-PD176252
6.25	Single	7WV9	PubMed 104895	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
6.25	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
6.25	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
6.25	Single	7XOX	Cholecystokinin-8	7XOX-CCK_B-Cholecystokinin-8-Gq/&β;1/&γ;2
6.25	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/&β;1/&γ;2
6.25	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2
6.25	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.25	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/&β;1/&γ;2
6.25	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
6.25	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2
6.25	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
6.25	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
6.25	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
6.25	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
6.25	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
6.25	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2
6.25	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2
6.25	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/&β;1/&γ;2
6.25	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
6.25	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/&β;1/&γ;2
6.25	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/&β;1/&γ;2
6.25	Single	8X16	Piclidenoson	8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
6.25	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/&β;1/&γ;2
6.25	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
6.25	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	5ht1b_on	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
6.25	Consensus	a2_on	Orthosteric Ligand	a2a_on a2b_on
6.25	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
6.25	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
6.25	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
6.25	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
6.25	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
6.25	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
6.25	Consensus	cyslt1_off_ortoallo	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
6.25	Consensus	ffa4_on	Orthosteric Ligand	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Consensus	gi_ffa	Orthosteric Ligand	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
6.25	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A_2A-NECA-Gs/&β;1/&γ;1 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Consensus	gs_compl-peptide	Orthosteric Ligand	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2
6.25	Consensus	gs_ffa	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2 8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
6.25	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
6.25	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.25	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
6.25	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
6.25	Consensus	mglu2_on	Other Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
6.25	Consensus	nts1_on_allo	Orthosteric Ligand	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
6.25	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
6.25	Consensus	s1p2_on	Orthosteric Ligand	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
5.88	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
5.88	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
5.88	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
5.88	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
5.88	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
5.88	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
5.88	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
5.88	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
5.88	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
5.88	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
5.88	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
5.88	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
5.88	Single	6KQI	PubMed 104895	6KQI-CB₁-PubMed 104895-ORG27569
5.88	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
5.88	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
5.88	Single	6OS2	TRV026	6OS2-AT₁-TRV026
5.88	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
5.88	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
5.88	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.88	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.88	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.88	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
5.88	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1
5.88	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2
5.88	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2
5.88	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
5.88	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
5.88	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
5.88	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
5.88	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
5.88	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
5.88	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
5.88	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/&β;1/&γ;2
5.88	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2
5.88	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2
5.88	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2
5.88	Single	8I95	EP54	8I95-C3a_B-EP54-Go/&β;1/&γ;2
5.88	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2
5.88	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2
5.88	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
5.88	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
5.88	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/&β;1/&γ;2
5.88	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
5.88	Single	8JWY	PubChem 168451710	8JWY-A_2A-PubChem 168451710
5.88	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/&β;1/&γ;2
5.88	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
5.88	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
5.88	Single	8WU1	KCA	8WU1-CB₁-KCA-Arrestin1
5.88	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
5.88	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg3_on
5.88	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
5.88	Consensus	cannabinoid_on	Orthosteric Ligand	cb1_on cb2_on
5.88	Consensus	cb1_off_allo	Orthosteric Ligand	6KQI-CB₁-PubMed 104895-ORG27569
5.88	Consensus	cb1_on	Orthosteric Ligand	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
5.88	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
5.88	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on
5.88	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
5.88	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
5.88	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
5.88	Consensus	dp_off	Orthosteric Ligand	dp2_off
5.88	Consensus	ep_on	Orthosteric Ligand	ep4_on ep2_on ep3_on
5.88	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
5.88	Consensus	gi_class-f	Other Ligand	gi_frizzled
5.88	Consensus	gi_frizzled	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.88	Consensus	gi_prostanoid	Orthosteric Ligand	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2 8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
5.88	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
5.88	Consensus	gs_bileacid	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
5.88	Consensus	gs_steroid	Orthosteric Ligand	gs_bileacid
5.88	Consensus	leuko_off	Orthosteric Ligand	blt_off cyslt_off
5.88	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
5.88	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
5.88	Consensus	nts_on	Orthosteric Ligand	nts1_on
5.88	Consensus	opioid_off	Orthosteric Ligand	kop_off mop_off nop_off dop_off
5.88	Consensus	prostanoid_on	Orthosteric Ligand	ep_on fpa_on
5.88	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
5.88	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
5.56	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
5.56	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
5.56	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
5.56	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
5.56	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
5.56	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
5.56	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
5.56	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
5.56	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
5.56	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
5.56	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
5.56	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2
5.56	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
5.56	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
5.56	Single	7EZC	UKA	7EZC-A_2A-UKA
5.56	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2
5.56	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
5.56	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
5.56	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
5.56	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2
5.56	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
5.56	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/&β;1/&γ;2
5.56	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/&β;1/&γ;2
5.56	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
5.56	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
5.56	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
5.56	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
5.56	Single	8GAG	YVF	8GAG-CB₁-YVF-Gi1/&β;1/&γ;2
5.56	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2
5.56	Single	8ID8	TUG-891	8ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
5.56	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
5.56	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
5.56	Single	8WRZ	8D0	8WRZ-CB₁-8D0-Arrestin1
5.56	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	adgrg2_on	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	beta1_off_allo	Orthosteric Ligand	4BVN-β₁-Cyanopindolol-Na
5.56	Consensus	bileacid_on	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
5.56	Consensus	c5a1_off_ortoallo	Orthosteric Ligand	6C1Q-C5a₁-PMX53-NDT9513727 6C1R-C5a₁-PMX53-Avacopan; Na
5.56	Consensus	cckb_on	Orthosteric Ligand	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
5.56	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
5.56	Consensus	cyslt2_off	Orthosteric Ligand	6RZ6-CysLT₂-ONO-2570366 6RZ9-CysLT₂-ONO-2770372 6RZ8-CysLT₂-ONO-2080365
5.56	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off
5.56	Consensus	ep2_on	Orthosteric Ligand	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
5.56	Consensus	ep4_on	Orthosteric Ligand	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2
5.56	Consensus	fpa_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
5.56	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
5.56	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
5.56	Consensus	gs_lipid	Orthosteric Ligand	gs_ffa gs_prostanoid
5.56	Consensus	gs_prostanoid	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.56	Consensus	steroid_on	Orthosteric Ligand	bileacid_on
5.26	Single	3NY9	PubChem 913103	3NY9-β₂-PubChem 913103
5.26	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
5.26	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
5.26	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
5.26	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
5.26	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
5.26	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
5.26	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
5.26	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
5.26	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
5.26	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.26	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
5.26	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
5.26	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
5.26	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.26	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
5.26	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
5.26	Single	7XY6	PubChem 11717831	7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
5.26	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
5.26	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
5.26	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
5.26	Single	8INR	Alpha-MSH	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/&β;1/&γ;2
5.26	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Single	8SAI	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine	8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
5.26	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/&β;1/&γ;2
5.26	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2 8I95-C3a_B-EP54-Go/&β;1/&γ;2
5.26	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
5.26	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
5.26	Consensus	class-d_off	Orthosteric Ligand	ste2_off
5.26	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
5.26	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.26	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
5.26	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
5.26	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
5.26	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
5.26	Consensus	gs_adgr	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	gs_bombesin	Orthosteric Ligand	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	gs_class-b2	Orthosteric Ligand	gs_adgr
5.26	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
5.26	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
5.26	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
5.26	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
5.26	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
5.00	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
5.00	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.00	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
5.00	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
5.00	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
5.00	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
5.00	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
5.00	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
5.00	Single	7QA8	Peptide	7QA8-STE2-Peptide
5.00	Single	7QA8	Peptide	7QA8-STE2-Peptide
5.00	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
5.00	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.00	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
5.00	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
5.00	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.00	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.00	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
5.00	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
5.00	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
5.00	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
5.00	Single	8G59	TUG-891	8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
5.00	Single	8GHV	PubChem 145964903	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
5.00	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/&β;1/&γ;2
5.00	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.00	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
5.00	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.00	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
5.00	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.00	Consensus	class-d_off	Orthosteric Ligand	ste2_off
5.00	Consensus	fpr-alx_on	Orthosteric Ligand	fpr1-alx_on fpr2-alx_on
5.00	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.00	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
5.00	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
5.00	Consensus	mop_off	Orthosteric Ligand	7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
5.00	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
5.00	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
5.00	Consensus	sst2_on	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
5.00	Consensus	sst_on	Orthosteric Ligand	sst2_on sst4_on
5.00	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
4.76	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
4.76	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
4.76	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
4.76	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
4.76	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
4.76	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
4.76	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
4.76	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
4.76	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.76	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
4.76	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
4.76	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
4.76	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
4.76	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
4.76	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
4.76	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
4.76	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
4.76	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
4.76	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
4.76	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Consensus	cx3cr_on	Orthosteric Ligand	cx3cr1_on
4.76	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
4.76	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
4.55	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
4.55	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
4.55	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
4.55	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
4.55	Single	7F4D	Alpha-MSH	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1
4.55	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
4.55	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
4.55	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
4.55	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
4.55	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
4.55	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
4.55	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;2
4.55	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
4.55	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
4.55	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
4.55	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
4.55	Consensus	cx3cr1_on	Orthosteric Ligand	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
4.55	Consensus	gi_formylpeptide	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
4.55	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
4.55	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
4.55	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
4.55	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
4.55	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
4.35	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
4.35	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
4.35	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
4.35	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
4.35	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.35	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.35	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
4.35	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
4.35	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
4.35	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
4.35	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
4.35	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.35	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
4.35	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
4.35	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
4.35	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
4.35	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2
4.35	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/&β;1/&γ;2
4.35	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
4.35	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.35	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.35	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
4.35	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
4.35	Consensus	gi_somatostatin	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
4.35	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
4.35	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
4.35	Consensus	nmur2_on	Orthosteric Ligand	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Consensus	nmur_on	Orthosteric Ligand	nmur1_on nmur2_on
4.35	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
4.35	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.17	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
4.17	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.17	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Single	7KH0	Acyclovir triphosphate	7KH0-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.17	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
4.17	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.17	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
4.17	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.17	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.17	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.17	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
4.17	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
4.17	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.17	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.17	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
4.17	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.17	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
4.17	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
4.17	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Consensus	bk1_on	Orthosteric Ligand	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Consensus	bombesin_on	Orthosteric Ligand	bb2_on bb1_on
4.17	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.17	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.17	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
4.17	Consensus	gs_bradykinin	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Consensus	gs_melanocortin	Orthosteric Ligand	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2
4.17	Consensus	gs_neuromedin	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
4.00	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
4.00	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
4.00	Single	6FJ3	PTH	6FJ3-PTH1-PTH
4.00	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.00	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.00	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/&β;1/&γ;2
4.00	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
4.00	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
4.00	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
4.00	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.00	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
4.00	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
4.00	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
4.00	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
4.00	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
4.00	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.00	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Consensus	bb1_on	Orthosteric Ligand	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
4.00	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
4.00	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.00	Consensus	class-d_on	Orthosteric Ligand	ste2_on
4.00	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.00	Consensus	ghrh_on	Orthosteric Ligand	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
4.00	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
4.00	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.00	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
4.00	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.00	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
3.85	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
3.85	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
3.85	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
3.85	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
3.85	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
3.85	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.85	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
3.85	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
3.85	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
3.85	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
3.85	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
3.85	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
3.85	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
3.85	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
3.85	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.85	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
3.85	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
3.85	Consensus	etb_on	Orthosteric Ligand	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
3.85	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
3.85	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
3.85	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.85	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
3.85	Consensus	go_class-b1	Orthosteric Ligand	go_crf
3.85	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.85	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
3.85	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.70	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
3.70	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
3.70	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
3.70	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.70	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
3.70	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
3.70	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
3.70	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
3.70	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
3.70	Single	7VGX	Neuropeptide Y	7VGX-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.70	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Single	8FEG	PRD_002517	8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
3.70	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
3.70	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
3.70	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
3.70	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
3.70	Consensus	crf1_on	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
3.70	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
3.70	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
3.70	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
3.70	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
3.70	Consensus	gs_endothelin	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
3.70	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
3.70	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
3.70	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
3.57	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
3.57	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
3.57	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
3.57	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
3.57	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.57	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
3.57	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
3.57	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
3.57	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
3.57	Consensus	gs_crf	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
3.45	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
3.45	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.45	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
3.45	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.45	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.45	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.45	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
3.45	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
3.33	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.33	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.33	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.33	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.33	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
3.23	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.23	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.23	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.23	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.23	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.23	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.23	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.23	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.23	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.23	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
3.23	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.12	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.12	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.12	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
3.12	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
3.03	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
2.94	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
2.94	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
2.94	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.86	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
2.86	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
2.78	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
2.78	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.70	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.70	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf

Consensus Members
	Id	Members
	8TLM	8TLM-CCR8-Anti-murine CCR8 antibody

Net Summary
I_min	3.59
Number of Linked Nodes	254
Number of Links	268
Number of Hubs	33
Number of Links mediated by Hubs	135
Number of Communities	7
Number of Nodes involved in Communities	31
Number of Links involved in Communities	37

Path Summary
Number Of Nodes in MetaPath	55
Number Of Links MetaPath	54
Number of Shortest Paths	47701
Length Of Smallest Path	3
Average Path Length	15.3267
Length of Longest Path	33
Minimum Path Strength	1.4
Average Path Strength	5.80771
Maximum Path Strength	22.59
Minimum Path Correlation	0.7
Average Path Correlation	0.972485
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5.88235
Average % Of Corr. Nodes	67.5772
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.3142
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
	Id	1^st Network	2^nd Network
	ccr8_off_on	ccr8_off	ccr8_on

This network is also present in following consensuses:
	Id	Components
	ccr_off	ccr5_off ccr8_off

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download ccr8_off.zip

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