Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x31 13.51406
21x50 6.3225409
31x52 6.445408
42x42 5.2475408
52x50 9.8925419
62x51 3.2075408
72x53 6.35418
82x60 8.35517
92x63 7.5417
10E1x50 6.95143719
113x33 9.21418
123x37 6.59508
133x39 7.46167619
143x49 9.3425439
153x52 6.5525407
16I2x53 8.0675439
17I2x57 7.39833638
184x50 4.735669
194x64 8.758517
20E2.R171 10.735477
21E2.Q177 7.3775414
22E2x50 6.955419
23E2x52 7.482517
24E2.F182 8.9025416
25E2.L183 6.27417
265x41 6.4575407
275x47 9.45167619
285x48 5.09407
296x44 9.675419
306x48 9.905818
317x34 11.05417
327x38 9.948517
337x39 7.838548
347x42 6.515618
357x45 6.73619
367x49 6.3425419
378x50 8.344529
388x51 4.04409
398x54 6.616529
408x57 3.232508
41Allo1 71.28191610
42Lig 9.9861010
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
12x60 7x42 14.93145.96YesYes178
22x57 7x42 17.55737.18NoYes088
31x39 2x57 15.39144.52NoNo068
42x53 7x42 29.50744.84YesYes188
52x53 7x46 30.91249.29YesNo189
62x50 7x46 23.774910.31YesNo199
71x50 2x50 58.86858.08YesYes099
81x50 7x50 48.16449.77YesNo099
91x49 7x50 46.78884.06NoNo099
101x49 1x52 42.61165.13NoYes098
111x52 8x54 26.651610.96YesYes089
128x50 8x54 14.37117.5YesYes299
136x47 7x40 17.51555.9NoNo088
147x45 7x49 49.99585.45YesYes199
157x49 7x53 1005.81YesNo099
162x46 7x53 97.51213.52NoNo099
172x46 3x42 96.20765.49NoNo098
182x45 3x42 85.369610.43NoNo698
192x45 4x46 85.33629.29NoNo099
202x42 4x46 83.93963.77YesNo089
212x42 3x49 78.24054.78YesYes089
223x49 I2x57 50.652316.68YesYes398
232x38 I2x57 23.151910.46NoYes078
242x38 4x39 19.68143.53NoNo075
252x41 4x39 10.85886.95NoNo075
261x52 8x57 14.40882.77YesYes088
272x39 I2x57 28.12766.03NoYes088
282x39 3x50 24.711513.26NoNo089
293x39 6x48 57.12496YesYes198
307x38 Lig 56.581413.67YesYes170
316x48 Lig 87.042114.11YesYes180
322x60 Allo1 13.0549.26YesYes170
332x63 Allo1 25.58966.17YesYes170
342x63 E1x50 20.1339.65YesYes179
353x28 E1x50 11.4868.43NoYes079
36Allo1 E2x51 22.67113.88YesNo104
37E2.V173 E2x51 20.877212.62NoNo044
38E2.R171 E2.V173 19.02077.85YesNo074
394x65 E2.R171 13.371814.02NoYes777
403x33 Lig 20.20411.96YesYes180
413x33 E2x52 15.6139.67YesYes187
424x64 Allo1 10.23168.45YesYes170
433x37 Lig 23.94634.85YesYes080
443x37 4x53 15.96845.78YesNo088
455x47 6x48 32.02466.01YesYes198
465x47 5x51 21.69687.87YesNo097
475x51 5x54 17.42353.04NoNo079
486x52 Lig 13.405311.01NoYes080
495x47 6x52 13.14625.37YesNo098
503x49 I2x53 24.581911.49YesYes399
513x52 I2x53 24.87469.28YesYes079
523x51 3x52 16.13565.16NoYes087
533x51 3x55 12.640111.24NoNo088
543x50 5x61 16.0982.51NoNo099
555x61 5x65 14.33351.52NoNo098
563x54 5x65 12.56066.35NoNo088
573x54 5x68 10.77943.92NoNo088
583x55 5x64 10.85885.64NoNo087
593x34 4x53 12.84081.62NoNo088
603x34 4x58 11.26441.7NoNo086
614x65 4x66 11.511112.4NoNo075
625x47 5x48 19.56439.28YesYes097
635x45 5x48 13.11675.99NoYes067
645x41 5x45 10.95088.71YesNo076
657x45 7x48 11.63242.83YesNo096
663x44 5x54 13.11672.83NoNo079
672x50 3x39 26.739413.1YesYes199
682x50 7x49 20.50518.08YesYes199
693x39 7x49 38.66036.03YesYes199
706x48 7x45 37.65687.91YesYes189
717x38 7x42 16.20256.95YesYes178
727x38 Allo1 57.52639.26YesYes170
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x3211.781NoNo8921
2x567x423.821NoYes8822
2x607x3812.911YesYes7721
2x607x425.961YesYes7822
2x60Allo19.261YesYes7022
3x327x4210.341NoYes9812
3x32Lig10.881NoYes9010
3x334x5711.581YesNo8812
3x334x613.631YesNo8712
3x33E2x529.671YesYes8712
3x33Lig11.961YesYes8010
3x366x484.941NoYes8811
3x36Lig8.751NoYes8010
3x373x404.30YesNo8912
3x373x418.160YesNo8712
3x374x535.780YesNo8812
3x374x579.860YesNo8812
3x37Lig4.850YesYes8010
3x396x4861YesYes9821
3x397x4512.051YesYes9922
4x61E2x527.361NoYes7722
5x461Lig8.040NoYes8010
5x476x444.291YesYes9922
5x476x486.011YesYes9821
5x476x5225.371YesNo9821
6x446x4821.051YesYes9821
6x447x454.831YesYes9922
6x476x484.851NoYes8821
6x477x457.311NoYes8922
6x487x4114.371YesNo8811
6x487x457.911YesYes8912
6x48Lig14.111YesYes8010
6x517x346.751NoYes8712
6x517x386.951NoYes8711
6x51Lig11.961NoYes8010
6x52Lig11.010NoYes8010
7x34Allo120.231YesYes7022
7x387x426.951YesYes7812
7x38Allo19.261YesYes7012
7x38Lig13.671YesYes7010
7x41Lig4.631NoYes8010
Allo1Allo1466.881YesYes0022
6x526x552.960NoNo8812

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
90.91Single4MQSIperoxo4MQS-M2-Iperoxo
90.91Single4U14Tiotropium4U14-M3-Tiotropium
90.91Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
90.91Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
83.33Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
83.33Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
83.33Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
81.82Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
81.82Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
76.92Single4U15Tiotropium4U15-M3-Tiotropium
76.92Single6OL9Tiotropium6OL9-M5-Tiotropium
76.92Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
76.92Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
76.92Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
75.00Single4DAJTiotropium4DAJ-M3-Tiotropium
75.00Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
75.00Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
75.00Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
75.00Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
75.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
75.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
75.00Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
75.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
75.00Consensushistamine_onOrthosteric Ligandh1_on h4_on
75.00Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
75.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
72.73Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
71.43Single5CXVTiotropium5CXV-M1-Tiotropium
71.43Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
71.43Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
69.23Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
69.23Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
69.23Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
69.23Single8EA0Iperoxo8EA0-M3-Iperoxo
69.23Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
66.67Single3RZECidoxepin3RZE-H1-Cidoxepin
66.67Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
66.67Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
66.67Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
66.67Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
66.67Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
66.67Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
66.67Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
66.67Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
66.67Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
64.29Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
64.29Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
64.29Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
64.29Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
64.29Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
64.29Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
64.29Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
64.29Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
64.29Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
63.64Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
63.64Single7SRQLSD7SRQ-5-HT2B-LSD
63.64Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
63.64Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
63.64Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
63.64Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
63.64Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
63.64Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
63.64Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
63.64Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
61.54Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
61.54Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
61.54Single5DSGTiotropium5DSG-M4-Tiotropium
61.54Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
61.54Single7WC7Lisuride7WC7-5-HT2A-Lisuride
61.54Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
61.54Single8JJOAlprenolol8JJO-β2-Alprenolol
61.54Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
61.54Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
61.54Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
61.54Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
61.54Single8X63Mepyramine8X63-H1-Mepyramine
61.54Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
61.54Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
61.54Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
61.54Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
61.54Consensustar_onOrthosteric Ligandta1_on
60.00Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
60.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
60.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
60.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
58.33Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
58.33Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
58.33Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
58.33Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
58.33Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
58.33Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
58.33Consensusalpha1_onOrthosteric Ligandalpha1a_on
58.33Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.33Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
58.33Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
58.33Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
58.33Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
57.14Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
57.14Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
57.14Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
57.14Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
57.14Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
57.14Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
57.14Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
57.14Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
57.14Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
57.14Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
56.25Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
54.55Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
54.55Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
54.55Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
53.85Single6A94Zotepine6A94-5-HT2A-Zotepine
53.85Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
53.85Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
53.85Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
53.85Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
53.85Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
53.85Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
53.85Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.85Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
53.85Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
53.85Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
53.85Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
53.85Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
53.85Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
53.85Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
53.85Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
53.85Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8GGIEpinephrine8GGI-β2-Epinephrine
53.85Single8GGKEpinephrine8GGK-β2-Epinephrine
53.85Single8GGMEpinephrine8GGM-β2-Epinephrine
53.85Single8GGPEpinephrine8GGP-β2-Epinephrine
53.85Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.85Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
53.85Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
53.85Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
53.85Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
53.85Consensus5ht5_onOrthosteric Ligand5ht5a_on
53.85Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
53.85Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
53.85Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
53.33Single2YDVNECA2YDV-A2A-NECA
53.33Single4UHRCGS216804UHR-A2A-CGS21680
53.33Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
53.33Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
53.33Single5G53NECA5G53-A2A-NECA-Gs
53.33Single6TQ7SB-3348676TQ7-OX1-SB-334867
53.33Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
53.33Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
53.33Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
53.33Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
53.33Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
53.33Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
53.33Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
53.33Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
53.33Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
53.33Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
53.33Consensushistamine_offOrthosteric Ligandh1_off
52.94Single7SK9CCX6627SK9-ACKR3-CCX662
52.94Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
50.00Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
50.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
50.00Single3NY8ICI 118-5513NY8-β2-ICI 118-551
50.00Single4AMIBucindolol4AMI-β1-Bucindolol
50.00Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
50.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
50.00Single6CM4Risperidone6CM4-D2-Risperidone
50.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
50.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
50.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
50.00Single6H7MSalbutamol6H7M-β1-Salbutamol
50.00Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
50.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
50.00Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
50.00Single6PS1Timolol6PS1-β2-Timolol
50.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
50.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
50.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
50.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
50.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
50.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
50.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
50.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
50.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
50.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
50.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GGJEpinephrine8GGJ-β2-Epinephrine
50.00Single8GGNEpinephrine8GGN-β2-Epinephrine
50.00Single8GGOEpinephrine8GGO-β2-Epinephrine
50.00Single8GGSEpinephrine8GGS-β2-Epinephrine
50.00Single8GGUEpinephrine8GGU-β2-Epinephrine
50.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
50.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
50.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
50.00Single8X64Desloratadine8X64-H1-Desloratadine
50.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
50.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
50.00Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
50.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
50.00Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
50.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
50.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
50.00Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
50.00Consensustachykinin_offOrthosteric Ligandnk1_off
47.06Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
47.06Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
47.06Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
47.06Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
47.06Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
47.06Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
47.06Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
47.06Single7UM4AS26747237UM4-5-HT5A-AS2674723
47.06Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
47.06Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
47.06Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
47.06Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
46.67Single2Y03Isoprenaline2Y03-β1-Isoprenaline
46.67Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
46.67Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
46.67Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
46.67Single6E67BI1671076E67-β2-BI167107-Gs (fused)
46.67Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
46.67Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
46.67Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
46.67Single6PS6Timolol6PS6-β2-Timolol
46.67Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
46.67Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
46.67Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
46.67Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
46.67Single7WC6LSD7WC6-5-HT2A-LSD
46.67Single7XKAEpinephrine7XKA-β2-Epinephrine
46.67Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
46.67Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
46.67Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
46.67Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
46.67Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
46.67Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
46.67Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
46.67Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
46.67Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
46.67Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
46.67Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
46.67Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
46.15Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
46.15Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
46.15Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
46.15Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
46.15Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
46.15Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
46.15Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
46.15Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
46.15Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
46.15Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
46.15Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
46.15Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
46.15Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
46.15Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
46.15Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single8GGVEpinephrine8GGV-β2-Epinephrine
46.15Single8GGWEpinephrine8GGW-β2-Epinephrine
46.15Single8GGXEpinephrine8GGX-β2-Epinephrine
46.15Single8GH0Epinephrine8GH0-β2-Epinephrine
46.15Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Single8IWESpermidine8IWE-TAAR9-Spermidine
46.15Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
46.15Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
46.15Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
46.15Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
45.45Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
45.45Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
45.00Single5WF5UK-4320975WF5-A2A-UK-432097
44.44Single3NY9PubChem 9131033NY9-β2-PubChem 913103
44.44Single4UG2CGS216804UG2-A2A-CGS21680
44.44Single8X5YAstemizole8X5Y-H1-Astemizole
43.75Single3P0GBI1671073P0G-β2-BI167107
43.75Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
43.75Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
43.75Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
43.75Single5V54Methiothepin5V54-5-HT1B-Methiothepin
43.75Single6E59L-7607356E59-NK1-L-760735
43.75Single6H7JIsoprenaline6H7J-β1-Isoprenaline
43.75Single6J20Aprepitant6J20-NK1-Aprepitant
43.75Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
43.75Single6WGTLSD6WGT-5-HT2A-LSD
43.75Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
43.75Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
43.75Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
43.75Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
43.75Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
43.75Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
43.75Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
43.75Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
43.75Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
43.75Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
43.75Consensus5ht1_offOrthosteric Ligand5ht1b_off
43.75Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
43.75Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
43.75Consensus5ht5_offOrthosteric Ligand5ht5a_off
43.75Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
43.75Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
43.75Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
43.75Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
43.75Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
42.86Single2YDOAdenosine2YDO-A2A-Adenosine
42.86Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
42.86Single6PS4ICI 118-5516PS4-β2-ICI 118-551
42.86Single6TPNHTL66416TPN-OX2-HTL6641
42.86Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
42.86Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
42.86Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
42.86Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
42.86Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
42.86Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
42.86Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
42.86Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
42.86Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
42.86Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GGLEpinephrine8GGL-β2-Epinephrine
42.86Single8GGQEpinephrine8GGQ-β2-Epinephrine
42.86Single8GGTEpinephrine8GGT-β2-Epinephrine
42.86Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
42.86Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
42.86Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
42.86Consensussensory_offOrthosteric Ligandopsin_off
42.11Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
42.11Single4IARErgotamine4IAR-5-HT1B-Ergotamine
41.67Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
41.67Single8GGREpinephrine8GGR-β2-Epinephrine
41.67Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
41.67Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Single4LDEBI1671074LDE-β2-BI167107
41.18Single6A93Risperidone6A93-5-HT2A-Risperidone
41.18Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
41.18Single6MXTSalmeterol6MXT-β2-Salmeterol
41.18Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
41.18Single7DFPSpiperone7DFP-D2-Spiperone
41.18Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
41.18Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
41.18Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
41.18Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
41.18Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
41.18Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Single7YITNalfurafine7YIT-κ-Nalfurafine
41.18Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
41.18Single8JJ8Formoterol8JJ8-β2-Formoterol
41.18Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
41.18Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
41.18Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
41.18Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
41.18Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
41.18Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
40.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
40.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
40.00Single2Y02Carmoterol2Y02-β1-Carmoterol
40.00Single2Y04Salbutamol2Y04-β1-Salbutamol
40.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
40.00Single3QAKUK-4320973QAK-A2A-UK-432097
40.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
40.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
40.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
40.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
40.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
40.00Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
40.00Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
40.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
40.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
40.00Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
40.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
40.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
40.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
40.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
40.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
40.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
40.00Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
40.00Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
40.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
40.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
40.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
40.00Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
40.00Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
40.00Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
40.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
40.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
38.89Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
38.89Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
38.89Single6H7LDobutamine6H7L-β1-Dobutamine
38.89Single6IBLArformoterol6IBL-β1-Arformoterol
38.89Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
38.89Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
38.89Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
38.89Consensusendothelin_offOrthosteric Ligandetb_off
38.89Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
38.89Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
38.46Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
38.46Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
38.46Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
38.46Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
38.46Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
38.46Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
38.46Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
38.46Single8GGYEpinephrine8GGY-β2-Epinephrine
38.46Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
38.46Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single5C1MBU725C1M-μ-BU72
37.50Single5TVNLSD5TVN-5-HT2B-LSD
37.50Single5WIUNemonapride5WIU-D4-Nemonapride
37.50Single5WIVNemonapride5WIV-D4-Nemonapride-Na
37.50Single5XPRBosentan5XPR-ETB-Bosentan
37.50Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
37.50Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
37.50Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
37.50Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
37.50Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
37.50Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
37.50Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
37.50Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
37.50Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
37.50Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
37.50Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
37.50Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
36.84Single5ZTYAM102575ZTY-CB2-AM10257
36.84Single6PT3DPI-2876PT3-δ-DPI-287
36.84Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
36.36Single7C61Ergotamine7C61-5-HT1B-Ergotamine
36.36Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
35.71Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
35.71Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
35.71Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
35.71Single6AKXA4R6AKX-CCR5-A4R
35.71Single6AKYMaraviroc6AKY-CCR5-Maraviroc
35.71Single6KUXRS-799486KUX-α2a-RS-79948
35.71Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
35.71Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
35.71Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
35.71Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
35.71Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
35.71Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
35.71Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
35.71Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
35.71Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
35.71Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
35.71Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
35.71Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
35.71Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
35.71Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
35.71Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
35.71Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
35.71Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
35.71Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
35.29Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
35.29Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
35.29Single4RWADIPP-NH24RWA-δ-DIPP-NH2
35.29Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
35.29Single5X93K-87945X93-ETB-K-8794
35.29Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
35.29Single6J21Aprepitant6J21-NK1-Aprepitant
35.29Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
35.29Single7B6WCyclazosin7B6W-α1b-Cyclazosin
35.29Single7EPENAM5637EPE-mGlu-NAM563
35.29Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
35.29Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
35.29Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
35.29Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
35.29Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
35.29Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
35.29Single8E0GBU728E0G-μ-BU72
35.29Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
35.29Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
35.29Consensusa2_onOrthosteric Liganda2a_on a2b_on
35.29Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
35.29Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
35.29Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
35.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
35.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
35.00Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
35.00Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
34.78Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
33.33Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
33.33Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
33.33Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
33.33Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
33.33Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
33.33Single4MBSMaraviroc4MBS-CCR5-Maraviroc
33.33Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
33.33Single6HLOAprepitant6HLO-NK1-Aprepitant
33.33Single6HLPNetupitant6HLP-NK1-Netupitant
33.33Single6TPGEMPA6TPG-OX2-EMPA
33.33Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
33.33Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
33.33Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
33.33Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
33.33Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Single7T32ZM2413857T32-A2A-ZM241385
33.33Single7VODCariprazine7VOD-5-HT2A-Cariprazine
33.33Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
33.33Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
33.33Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
33.33Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
33.33Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
33.33Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
33.33Single8JJLOlodaterol8JJL-β2-Olodaterol
33.33Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
33.33Single8JWZAB9288JWZ-A2A-AB928-Na
33.33Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
33.33Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
33.33Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
33.33Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
33.33Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
33.33Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
33.33Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
33.33Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
33.33Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
33.33Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
31.82Single6PT2KGCHM076PT2-δ-KGCHM07
31.58Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
31.58Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
31.58Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
31.58Single7EZCUKA7EZC-A2A-UKA
31.58Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
31.58Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
31.58Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
31.58Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Single2Y01Dobutamine2Y01-β1-Dobutamine
31.25Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
31.25Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
31.25Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
31.25Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
31.25Single5TGZAM65385TGZ-CB1-AM6538
31.25Single6TOTLemborexant6TOT-OX1-Lemborexant
31.25Single7BU7BI1671077BU7-β1-BI167107
31.25Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
31.25Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
31.25Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
31.25Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.25Single8CU6LJ-45178CU6-A2A-LJ-4517
31.25Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
31.25Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
31.25Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
31.25Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
31.25Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
31.25Consensusadenosine_onOrthosteric Liganda1_on a2_on
31.25Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
31.25Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.25Consensusblt_onOrthosteric Ligandblt1_on
31.25Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.25Consensusleuko_onOrthosteric Ligandblt_on
31.25Consensusnucleotide_onOrthosteric Ligandadenosine_on
30.77Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
30.77Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
30.77Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
30.77Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
30.77Single8GGZEpinephrine8GGZ-β2-Epinephrine
30.77Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
30.00Single5WF6UK-4320975WF6-A2A-UK-432097
30.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
29.41Single2Y00Dobutamine2Y00-β1-Dobutamine
29.41Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
29.41Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
29.41Single5CGCHTL142425CGC-mGlu5-HTL14242
29.41Single5NM2ZM2413855NM2-A2A-ZM241385-Na
29.41Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
29.41Single5WQCEMPA5WQC-OX2-EMPA
29.41Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
29.41Single6LUQHaloperidol6LUQ-D2-Haloperidol
29.41Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
29.41Single6TP6Filorexant6TP6-OX1-Filorexant
29.41Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
29.41Single7C4SS1P7C4S-S1P3-S1P
29.41Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
29.41Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
29.41Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
29.41Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
29.41Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
29.41Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
29.41Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
29.41Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
29.17Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
28.57Single3PBLEticlopride3PBL-D3-Eticlopride
28.57Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
28.57Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
28.57Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
28.57Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
28.57Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
28.57Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
28.57Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
28.57Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8GH1Epinephrine8GH1-β2-Epinephrine
28.57Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
28.57Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
28.57Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
28.57Consensusgo_class-b2Orthosteric Ligandgo_adhesion
28.57Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
28.57Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
28.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
27.78Single4DJHJDTic4DJH-κ-JDTic
27.78Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
27.78Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
27.78Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
27.78Single7W41PD1762527W41-BB2-PD176252
27.78Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
27.78Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
27.78Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
27.78Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
27.78Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
27.78Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
27.78Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Consensusadenosine_offOrthosteric Liganda1_off a2_off
27.78Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
27.78Consensusbombesin_offOrthosteric Ligandbb2_off
27.78Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
27.78Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
27.78Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
27.78Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
27.27Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
27.27Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
27.27Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
27.27Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
27.27Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
26.92Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
26.67Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
26.67Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
26.67Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
26.67Single4S0VSuvorexant4S0V-OX2-Suvorexant
26.67Single5DHHSB-6121115DHH-NOP-SB-612111
26.67Single6B73PubChem 1319551386B73-κ-PubChem 131955138
26.67Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
26.67Single6ME2Ramelteon6ME2-MT1-Ramelteon
26.67Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
26.67Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
26.67Single6TODEMPA6TOD-OX1-EMPA-Na
26.67Single6TPJSuvorexant6TPJ-OX2-Suvorexant
26.67Single7F8ULintitript7F8U-CCKA-Lintitript
26.67Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
26.67Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
26.67Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
26.67Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
26.67Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
26.67Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
26.67Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
26.67Consensusgt_class-aOrthosteric Ligandgt_opsin
26.67Consensusgt_opsinOrthosteric Ligandgt_sensory
26.67Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
26.67Consensusmglu_onOther Ligandmglu2_on mglu4_on
26.67Consensusorexin_offOrthosteric Ligandox2_off ox1_off
26.32Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.32Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
26.32Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
26.32Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
26.32Single7K15MKD0467K15-BLT1-MKD046-Na
26.32Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
26.32Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
26.32Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
26.32Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
26.32Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
26.32Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
26.32Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single8WU1KCA8WU1-CB1-KCA-Arrestin1
26.32Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
26.32Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
26.32Consensusblt_offOrthosteric Ligandblt1_off
26.32Consensusclass-b2_onOrthosteric Ligandadgrg_on
26.32Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
26.32Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
26.32Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
26.09Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
26.09Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
26.09Consensusangiotensin_onOrthosteric Ligandat1_on
26.09Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
26.09Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.09Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
25.00Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
25.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
25.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
25.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
25.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
25.00Single5CGDHTL142425CGD-mGlu5-HTL14242
25.00Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
25.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
25.00Single5JTBZM2413855JTB-A2A-ZM241385
25.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
25.00Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
25.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
25.00Single6AQFZM2413856AQF-A2A-ZM241385
25.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
25.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
25.00Single6IQLL7458706IQL-D4-L745870
25.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
25.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
25.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
25.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
25.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
25.00Single6TPKRetosiban6TPK-OT-Retosiban
25.00Single6VI4JDTic6VI4-κ-JDTic
25.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
25.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
25.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
25.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
25.00Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
25.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
25.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
25.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
25.00Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
25.00Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
25.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
25.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.00Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusorexin_onOrthosteric Ligandox2_on
25.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
25.00Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
25.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
25.00Consensuss1p_offOrthosteric Ligands1p1_off
25.00Consensusvasopressin-ot_offOrthosteric Ligandot_off
24.00Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
23.81Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
23.81Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
23.81Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
23.81Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
23.81Consensuslpl_offOrthosteric Ligands1p_off lpa_off
23.81Consensuslpl_onOrthosteric Ligands1p_on lpa_on
23.81Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
23.53Single3EMLZM2413853EML-A2A-ZM241385
23.53Single4EIYZM2413854EIY-A2A-ZM241385-Na
23.53Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
23.53Single5IU8Q274563475IU8-A2A-Q27456347-Na
23.53Single5K2AZM2413855K2A-A2A-ZM241385-Na
23.53Single5OLGZM2413855OLG-A2A-ZM241385-Na
23.53Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
23.53Single5VRAZM2413855VRA-A2A-ZM241385-Na
23.53Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
23.53Single6FFHFenobam6FFH-mGlu5-Fenobam
23.53Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
23.53Single6S0LZM2413856S0L-A2A-ZM241385
23.53Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
23.53Single7F83PF-051904577F83-Ghrelin-PF-05190457
23.53Single7PYRPSB-21157PYR-A2A-PSB-2115
23.53Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
23.53Single7UL4Alvimopan7UL4-μ-Alvimopan
23.53Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
23.53Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
23.53Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
23.53Consensusa2_offOrthosteric Liganda2a_off
23.53Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
23.53Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
23.53Consensusgi_hcarOrthosteric Ligandgi_hca
23.53Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
23.53Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
23.08Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
23.08Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
23.08Consensussensory_onOrthosteric Ligandopsin_on
22.73Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
22.73Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
22.73Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
22.73Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
22.73Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
22.73Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
22.73Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
22.22Single5IUAQ274563485IUA-A2A-Q27456348-Na
22.22Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
22.22Single5N2SPSB365N2S-A1-PSB36
22.22Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
22.22Single6D26Fevipiprant6D26-DP2-Fevipiprant
22.22Single6LPLZM2413856LPL-A2A-ZM241385-Na
22.22Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
22.22Single6S0QZM2413856S0Q-A2A-ZM241385
22.22Single6WQAZM2413856WQA-A2A-ZM241385-Na
22.22Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
22.22Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
22.22Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
22.22Single7RM5ZM2413857RM5-A2A-ZM241385-Na
22.22Single7SINNPS-21437SIN-CaS-NPS-2143
22.22Single7SINNPS-21437SIN-CaS-NPS-2143
22.22Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
22.22Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
22.22Single8FYNZM2413858FYN-A2A-ZM241385-Na
22.22Single8GNEKW-63568GNE-A2A-KW-6356-Na
22.22Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
22.22Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.22Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
22.22Single8QOTNanobody E8QOT-μ-Nanobody E
22.22Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
22.22Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
22.22Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
22.22Consensusendothelin_onOrthosteric Ligandetb_on eta_on
22.22Consensusgo_class-b1Orthosteric Ligandgo_crf
22.22Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
21.43Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
21.43Single3UZAGTPL92363UZA-A2A-GTPL9236
21.43Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
21.43Single6IGLIRL16206IGL-ETB-IRL1620
21.43Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
21.43Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
21.43Single7WC5Psilocin7WC5-5-HT2A-Psilocin
21.43Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.43Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
21.43Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
21.43Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
21.43Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
21.05Single5XR8AM8415XR8-CB1-AM841
21.05Single5XRAAM115425XRA-CB1-AM11542
21.05Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
21.05Single7P2L4YI7P2L-mGlu5-4YI
21.05Single7PX4PSB-21137PX4-A2A-PSB-2113
21.05Single7TUYGSK682753A7TUY-GPR183-GSK682753A
21.05Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
21.05Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
21.05Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
21.05Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
21.05Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
21.05Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
21.05Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
21.05Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
21.05Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
21.05Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
21.05Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
21.05Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
21.05Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
21.05Consensuslpa_offOrthosteric Ligandlpa1_off
21.05Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
21.05Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
20.83Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
20.83Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
20.69Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.69Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
20.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
20.00Single6HLLCP999946HLL-NK1-CP99994
20.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
20.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
20.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
20.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
20.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
20.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
20.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
20.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
20.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
20.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
20.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
20.00Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
20.00Single8K5BNiacin8K5B-HCA2-Niacin
20.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
20.00Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
20.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
20.00Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
20.00Consensusdp_offOrthosteric Liganddp2_off
20.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
20.00Consensusgi_class-fOther Ligandgi_frizzled
20.00Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
20.00Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
20.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
20.00Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.00Consensusgs_steroidOrthosteric Ligandgs_bileacid
20.00Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
20.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
19.23Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
19.23Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
19.23Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
19.23Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single6K1QIRL25006K1Q-ETB-IRL2500
19.05Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.05Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
19.05Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
19.05Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
19.05Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
19.05Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
19.05Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
19.05Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensussteroid_onOrthosteric Ligandbileacid_on
18.75Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
18.75Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
18.75Single5K2DZM2413855K2D-A2A-ZM241385
18.75Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
18.75Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
18.75Single5U09Taranabant5U09-CB1-Taranabant
18.75Single5WS3EMPA5WS3-OX2-EMPA
18.75Single6JZHZM2413856JZH-A2A-ZM241385-Na
18.75Single6PS7ZM2413856PS7-A2A-ZM241385-Na
18.75Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
18.75Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
18.75Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
18.75Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
18.75Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
18.75Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
18.75Single7XRRLemborexant7XRR-OX2-Lemborexant
18.75Single8GNGIstradefylline8GNG-A2A-Istradefylline
18.75Single8IHKAcifran8IHK-HCA3-Acifran
18.75Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
18.75Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
18.75Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
18.75Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
18.52Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensusclass-d_onOrthosteric Ligandste2_on
18.52Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
18.18Single5EE7MK08935EE7-Glucagon-MK0893
18.18Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
18.18Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
18.18Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
18.18Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
18.18Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single7XN9L-054,5227XN9-SST2-L-054,522
18.18Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
18.18Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
18.18Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
18.18Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
18.18Consensusclass-d_offOrthosteric Ligandste2_off
18.18Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
18.18Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
18.18Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Consensusgs_class-b2Orthosteric Ligandgs_adgr
18.18Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
17.86Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.86Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
17.86Consensusgi_class-dOrthosteric Ligandgi_ste
17.86Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.86Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
17.65Single3REYPubChem 56973REY-A2A-PubChem 5697
17.65Single5IU4ZM2413855IU4-A2A-ZM241385-Na
17.65Single5IUBQ274563445IUB-A2A-Q27456344-Na
17.65Single5K2CZM2413855K2C-A2A-ZM241385-Na
17.65Single5NLXZM2413855NLX-A2A-ZM241385-Na
17.65Single5NM4ZM2413855NM4-A2A-ZM241385-Na
17.65Single5UVIZM2413855UVI-A2A-ZM241385
17.65Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
17.65Single6MH8ZM2413856MH8-A2A-ZM241385
17.65Single6V9SGTPL114036V9S-OX1-GTPL11403
17.65Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
17.65Single7AROLUF58337ARO-A2A-LUF5833-Na
17.65Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
17.65Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
17.65Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
17.65Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
17.65Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
17.65Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
17.65Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
17.65Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
17.65Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
17.65Single8K5CAcipimox8K5C-HCA2-Acipimox
17.65Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
17.65Consensushca_onOrthosteric Ligandhca2_on hca3_on
17.65Consensushcar_onOrthosteric Ligandhca_on
17.39Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.39Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Single7F8XNN90567F8X-CCKA-NN9056
17.39Single7QA8Peptide7QA8-STE2-Peptide
17.39Single7QA8Peptide7QA8-STE2-Peptide
17.39Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
17.39Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
17.39Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
17.39Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
17.39Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
17.39Consensusclass-d_offOrthosteric Ligandste2_off
17.39Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
17.39Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
17.39Consensussst_onOrthosteric Ligandsst2_on sst4_on
17.39Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
17.24Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
17.24Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
17.24Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
17.24Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
17.24Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
17.24Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.24Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
17.24Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
17.24Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
16.67Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
16.67Single4YAYZD-71554YAY-AT1-ZD-7155
16.67Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
16.67Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
16.67Single5GLHEndothelin-15GLH-ETB-Endothelin-1
16.67Single5MZPCaffeine5MZP-A2A-Caffeine-Na
16.67Single5UENDU1725UEN-A1-DU172
16.67Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
16.67Single6D27CAY104716D27-DP2-CAY10471
16.67Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
16.67Single6GPSMK08126GPS-CCR2-MK0812
16.67Single6IGKEndothelin-36IGK-ETB-Endothelin-3
16.67Single6IIVDaltroban6IIV-TP-Daltroban
16.67Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
16.67Single6LPJZM2413856LPJ-A2A-ZM241385-Na
16.67Single6LPKZM2413856LPK-A2A-ZM241385-Na
16.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
16.67Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
16.67Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
16.67Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
16.67Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
16.67Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
16.67Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
16.67Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
16.67Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
16.67Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
16.67Single8K5DGSK2560738K5D-HCA2-GSK256073
16.67Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
16.67Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
16.67Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
16.67Consensuscck_offOrthosteric Ligandccka_off
16.67Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
16.67Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
16.67Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
16.67Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
16.67Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
16.67Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
16.67Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
16.13Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.13Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
16.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
16.00Single6W25SHU91196W25-MC4-SHU9119-Ca
16.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
16.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
16.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
15.79Single4NTJAZD12834NTJ-P2Y12-AZD1283
15.79Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
15.79Single6GPXMK08126GPX-CCR2-MK0812
15.79Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
15.79Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
15.79Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
15.79Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
15.79Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
15.79Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
15.79Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
15.79Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
15.79Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
15.79Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
15.79Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
15.62Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
15.62Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
15.38Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
15.38Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
15.38Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.38Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
15.38Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8PWNTheophylline8PWN-A2A-Theophylline
15.38Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
15.38Consensusclass-d_onOrthosteric Ligandste2_on
15.38Consensusgi_class-dOrthosteric Ligandgi_ste
15.38Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
15.38Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.15Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
15.15Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
15.15Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
15.15Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.15Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
15.15Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
15.00Single5TZR-5TZR-FFA1 (GPR40)-MK8666
15.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
15.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.00Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
15.00Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
15.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
15.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
15.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
15.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
15.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
15.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
15.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
15.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
15.00Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
15.00Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.00Consensuslpa_onOrthosteric Ligandlpa1_on
15.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
14.81Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
14.81Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
14.81Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
14.81Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
14.81Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
14.81Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
14.81Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
14.81Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
14.81Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
14.81Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
14.81Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
14.81Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.71Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
14.71Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
14.71Consensuspth_onOrthosteric Ligandpth1_on pth2_on
14.29Single3RFMCaffeine3RFM-A2A-Caffeine
14.29Single4N4WSANT-14N4W-SMO-SANT-1
14.29Single5X33BIIL2605X33-BLT1-BIIL260
14.29Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
14.29Single6FJ3PTH6FJ3-PTH1-PTH
14.29Single6IIURamatroban6IIU-TP-Ramatroban
14.29Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
14.29Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
14.29Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
14.29Single6TQ9SB-4081246TQ9-OX1-SB-408124
14.29Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
14.29Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
14.29Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
14.29Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
14.29Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
14.29Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
14.29Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
14.29Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
14.29Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
14.29Single8A2OTheophylline8A2O-A2A-Theophylline-Na
14.29Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
14.29Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
14.29Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
14.29Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
14.29Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
14.29Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
14.29Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
14.29Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
14.29Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
14.29Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
13.89Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.79Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
13.79Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
13.79Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
13.79Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
13.79Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
13.79Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
13.79Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
13.79Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
13.79Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.64Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
13.64Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
13.64Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
13.64Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
13.64Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
13.64Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
13.64Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
13.64Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
13.64Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
13.64Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
13.64Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
13.33Single3OE6IT1t3OE6-CXCR4-IT1t
13.33Single3OE8IT1t3OE8-CXCR4-IT1t
13.33Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
13.33Single6LMLGlucagon6LML-Glucagon-Glucagon
13.33Single6ME5Agomelatine6ME5-MT1-Agomelatine
13.33Single6ME9Ramelteon6ME9-MT2-Ramelteon
13.33Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
13.33Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
13.33Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
13.33Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
13.33Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
13.33Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
13.33Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
13.33Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
13.33Single8IY6Endothelin-18IY6-ETB-Endothelin-1
13.33Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
13.33Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
13.33Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
13.33Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
13.33Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
13.04Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
13.04Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
13.04Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
13.04Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
13.04Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
13.04Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
13.04Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
13.04Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
13.04Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
13.04Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
12.90Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
12.50Single3OE9IT1t3OE9-CXCR4-IT1t
12.50Single4XT1Fractalkine4XT1-US28-Fractalkine
12.50Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
12.50Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
12.50Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
12.50Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
12.50Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
12.50Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
12.50Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
12.50Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
12.50Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
12.50Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Consensusglp_onOrthosteric Ligandglp1_on glp2_on
12.50Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
12.50Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
12.50Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
12.12Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
12.12Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
12.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
12.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
12.00Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
12.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
12.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
12.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
12.00Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
12.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
12.00Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
11.76Single3ODUIT1t3ODU-CXCR4-IT1t
11.76Single3PWHZM2413853PWH-A2A-ZM241385
11.76Single5ZKQABT-4915ZKQ-PAF-ABT-491
11.76Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
11.76Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
11.76Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.76Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
11.76Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
11.76Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
11.76Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
11.76Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
11.76Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.76Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
11.76Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
11.76Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.54Single3OE0CVX153OE0-CXCR4-CVX15
11.54Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
11.54Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
11.54Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
11.54Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
11.54Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
11.54Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
11.54Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
11.54Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
11.11Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
11.11Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
11.11Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.11Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.11Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
11.11Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
11.11Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
11.11Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
11.11Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
11.11Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
11.11Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
11.11Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
11.11Single8IYXYL-3658IYX-GPR34-YL-365
11.11Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
11.11Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
11.11Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
11.11Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
11.11Consensusgnrh_offOrthosteric Ligandgnrh1_off
11.11Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
11.11Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
11.11Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.81Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
10.71Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
10.71Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
10.71Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
10.71Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
10.71Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
10.71Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
10.71Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
10.71Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
10.71Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
10.53Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
10.53Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
10.53Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
10.53Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
10.53Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
10.53Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
10.53Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
10.53Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
10.53Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
10.53Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
10.53Consensushcar_offOrthosteric Ligandsuccinate_off
10.53Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
10.53Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
10.53Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
10.53Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
10.34Single4XT3Fractalkine4XT3-US28-Fractalkine
10.34Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.34Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.34Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
10.34Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
10.34Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
10.34Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.34Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
10.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
10.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
10.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
10.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
10.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
10.00Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
10.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
10.00Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
10.00Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
10.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
10.00Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
10.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
10.00Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
10.00Consensusclass-c_offOther Ligandgabab_off mglu_off
10.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
10.00Consensusep_offOrthosteric Ligandep4_off
10.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
10.00Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
10.00Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.68Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
9.68Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
9.68Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
9.68Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.52Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
9.52Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
9.52Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
9.52Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
9.52Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
9.52Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
9.52Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
9.52Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
9.52Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
9.52Consensuschemerin_onOrthosteric Ligandcml1_on
9.52Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
9.52Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
9.38Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
9.38Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
9.09Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
9.09Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
9.09Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
9.09Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
9.09Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
9.09Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
9.09Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
9.09Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
9.09Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
9.09Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
8.82Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
8.82Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
8.82Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
8.82Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
8.70Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
8.70Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
8.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
8.70Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
8.70Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
8.70Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
8.70Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
8.70Consensuscyslt_offOrthosteric Ligandcyslt2_off
8.57Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.33Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
8.33Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
8.33Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
8.33Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.33Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.33Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
8.33Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
8.00Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
8.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
8.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
8.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
8.00Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
8.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
8.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
8.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
8.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
7.89Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
7.69Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.69Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
7.69Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
7.69Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
7.69Single7SHEPI; PE7SHE-GPR158-PI; PE
7.69Single7SK5CXCL127SK5-ACKR3-CXCL12
7.69Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.69Consensussst_offOrthosteric Ligandsst2_off
7.50Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
7.41Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
7.41Single7XNACYN1548067XNA-SST2-CYN154806
7.41Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
7.41Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
7.41Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
7.14Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.14Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
7.14Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
7.14Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
7.14Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
7.14Consensusclass-c_onOther Ligandgabab_on mglu_on
7.14Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
6.90Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
6.90Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
6.90Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
6.67Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
6.67Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
6.67Single7SK3CXCL127SK3-ACKR3-CXCL12
6.67Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
6.67Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
6.67Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
6.45Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.45Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
6.25Single6LI0GTPL98046LI0-GPR52-GTPL9804
6.25Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
6.25Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
6.25Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
6.25Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
6.25Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
6.06Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.88Single5L7IVismodegib5L7I-SMO-Vismodegib
5.88Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
5.88Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
5.88Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
5.88Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.88Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.88Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
5.88Consensusclass-t_onOrthosteric Ligandtaste2_on
5.88Consensusgs_class-tOrthosteric Ligandgs_taste
5.88Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.88Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.88Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.88Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.56Single4K5YCP-3763954K5Y-CRF1-CP-376395
5.56Single7F8YDevazepide7F8Y-CCKA-Devazepide
5.56Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.56Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
5.56Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.56Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
5.56Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
5.56Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.56Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.56Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
5.26Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
5.26Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.26Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
5.26Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
5.26Single8K2WAMG4878K2W-CXCR3-AMG487
5.26Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
5.26Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
5.26Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.26Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
5.26Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
5.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
5.00Single4Z9GCP-3763954Z9G-CRF1-CP-376395
5.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
5.00Single8GTIBMK-C2058GTI-CRF1-BMK-C205
5.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
4.76Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
4.76Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
4.76Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
4.76Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.76Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.76Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
4.55Single5V56TC1145V56-SMO-TC114
4.55Single5V57TC1145V57-SMO-TC114
4.55Single6OS1TRV0266OS1-AT1-TRV026
4.55Single7F1TMIP-1a7F1T-CCR5-MIP-1a
4.55Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
4.55Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
4.55Consensusrelaxin_onOrthosteric Ligandrxfp4_on
4.35Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.35Single4PY02MeSATP4PY0-P2Y12-2MeSATP
4.35Single6OS2TRV0266OS2-AT1-TRV026
4.35Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
4.35Single7SHEPI; PE7SHE-GPR158-PI; PE
4.35Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.35Single8GTMBMK-C2038GTM-CRF1-BMK-C203
4.35Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.35Consensuschemokine_offOrthosteric Ligandcxcr_off
4.35Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
4.35Consensuscxcr_offOrthosteric Ligandcxcr4_off
4.35Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.17Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
4.17Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
4.17Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
4.17Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
4.17Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
4.17Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
4.17Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
4.00Single6KNMJN241-96KNM-Apelin-JN241-9
4.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
4.00Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
4.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
3.85Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
3.85Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
3.70Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
3.70Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
3.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.57Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
3.45Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
3.23Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
3.12Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
3.03Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
2.44Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x602x643.521YesNo7712
2x607x3510.11YesNo7611
2x607x3812.911YesYes7711
2x607x425.961YesYes7812
2x60Allo19.261YesYes7010
2x63E1x509.651YesYes7912
2x63E2.Q17710.151YesYes7411
2x63E2x504.031YesYes7912
2x63Allo16.171YesYes7010
2x647x359.281NoNo7621
E1x50E2x5011.751YesYes9922
4x644x674.561YesNo7412
4x644x687.361YesNo7412
4x64E2.Q1814.381YesNo7812
4x64E2.F18219.041YesYes7612
4x64Allo18.451YesYes7010
E2.E170E2.T1725.641NoNo4411
Allo1E2.E17029.351YesNo0401
E2.Q181E2.T1729.920NoNo8421
Allo1E2.T17212.971YesNo0401
E2.V173E2x5112.620NoNo4421
E2.L174E2.Q1775.321NoYes3411
Allo1E2.L17430.821YesNo0301
Allo1E2.Q17712.41YesYes0401
Allo1E2x5113.881YesNo0401
5x37Allo113.010NoYes5010
6x517x346.751NoYes8721
6x517x386.951NoYes8721
6x51Lig11.961NoYes8022
6x587x347.410NoYes5721
7x34E3.V3959.811YesNo7612
7x31Allo121.090NoYes3010
7x34Allo120.231YesYes7010
7x35Allo116.761NoYes6010
7x387x426.951YesYes7812
7x38Allo19.261YesYes7010
7x38Lig13.671YesYes7012
Allo1E2.S1843.11YesNo0601
E2.G176E2.Q1771.640NoYes2421

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
72.73Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
66.67Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
63.64Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
58.33Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
54.55Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
50.00Single6OS2TRV0266OS2-AT1-TRV026
50.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
50.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
50.00Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
50.00Consensusdp_offOrthosteric Liganddp2_off
50.00Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
47.06Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
46.67Single6D26Fevipiprant6D26-DP2-Fevipiprant
46.15Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
44.44Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
44.44Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
43.75Single6OS1TRV0266OS1-AT1-TRV026
42.86Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
42.86Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
42.86Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
42.86Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
42.11Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
41.67Single3OE6IT1t3OE6-CXCR4-IT1t
41.18Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
41.18Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.18Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
40.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
40.00Single6D27CAY104716D27-DP2-CAY10471
40.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
40.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
40.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
40.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
40.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
40.00Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
38.89Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
38.89Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
38.46Single3OE9IT1t3OE9-CXCR4-IT1t
38.46Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
38.10Consensusangiotensin_onOrthosteric Ligandat1_on
38.10Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
37.50Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
36.84Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
36.84Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.36Single6JODAngiotensin II6JOD-AT2-Angiotensin II
36.36Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
36.36Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
36.36Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
36.36Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
35.71Single3ODUIT1t3ODU-CXCR4-IT1t
35.71Single8GNGIstradefylline8GNG-A2A-Istradefylline
35.71Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
35.71Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
35.29Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
35.29Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
35.29Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
35.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
35.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
35.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
33.33Single4XT3Fractalkine4XT3-US28-Fractalkine
33.33Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
33.33Single6MH8ZM2413856MH8-A2A-ZM241385
33.33Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
33.33Single7AROLUF58337ARO-A2A-LUF5833-Na
33.33Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
33.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
33.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
33.33Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
33.33Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
33.33Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
33.33Consensuschemokine_offOrthosteric Ligandcxcr_off
33.33Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
33.33Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
33.33Consensuscxcr_offOrthosteric Ligandcxcr4_off
33.33Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
33.33Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
33.33Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
33.33Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
33.33Consensushca_onOrthosteric Ligandhca2_on hca3_on
33.33Consensushcar_onOrthosteric Ligandhca_on
32.00Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
32.00Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
32.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
32.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
31.82Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
31.82Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
31.82Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
31.82Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
31.82Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
31.25Single6LPJZM2413856LPJ-A2A-ZM241385-Na
31.25Single6LPKZM2413856LPK-A2A-ZM241385-Na
31.25Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
31.25Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
31.25Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
31.25Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
31.25Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
30.77Single3OE8IT1t3OE8-CXCR4-IT1t
30.77Single6IGLIRL16206IGL-ETB-IRL1620
30.77Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
30.77Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
30.43Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
30.43Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
30.43Single7C61Ergotamine7C61-5-HT1B-Ergotamine
30.43Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
30.43Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
30.43Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
30.43Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
30.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
30.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
30.00Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
30.00Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
30.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
29.63Single6IGKEndothelin-36IGK-ETB-Endothelin-3
29.41Single5IUAQ274563485IUA-A2A-Q27456348-Na
29.41Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
29.41Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
29.41Single6LPLZM2413856LPL-A2A-ZM241385-Na
29.41Single6S0QZM2413856S0Q-A2A-ZM241385
29.41Single6WQAZM2413856WQA-A2A-ZM241385-Na
29.41Single7RM5ZM2413857RM5-A2A-ZM241385-Na
29.41Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
29.41Single8FYNZM2413858FYN-A2A-ZM241385-Na
29.41Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
29.17Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
29.17Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
29.17Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
29.17Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
29.17Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
29.17Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
29.17Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
29.17Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.17Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
29.17Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
28.57Single4XT1Fractalkine4XT1-US28-Fractalkine
28.57Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
28.57Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
28.57Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
28.57Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
28.57Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
28.57Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
28.57Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
28.57Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
28.57Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
28.57Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
28.57Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
28.57Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
28.57Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
28.57Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
28.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
28.00Single7SK3CXCL127SK3-ACKR3-CXCL12
28.00Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
28.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
28.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
27.78Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
27.78Single7F1TMIP-1a7F1T-CCR5-MIP-1a
27.78Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
27.78Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
27.78Single7PX4PSB-21137PX4-A2A-PSB-2113
27.78Single7TUYGSK682753A7TUY-GPR183-GSK682753A
27.78Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
27.78Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
27.78Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
27.78Consensuscck_onOrthosteric Ligandccka_on cckb_on
27.78Consensuschemerin_onOrthosteric Ligandcml1_on
27.78Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
27.78Consensusrelaxin_onOrthosteric Ligandrxfp4_on
27.59Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
27.27Single7SK5CXCL127SK5-ACKR3-CXCL12
27.27Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
27.27Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
27.27Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
27.27Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
27.27Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
26.92Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
26.92Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
26.67Single3PWHZM2413853PWH-A2A-ZM241385
26.67Single5ZKQABT-4915ZKQ-PAF-ABT-491
26.67Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
26.67Single8IHKAcifran8IHK-HCA3-Acifran
26.67Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
26.67Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
26.32Single6A93Risperidone6A93-5-HT2A-Risperidone
26.32Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
26.32Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
26.32Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
26.32Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
26.32Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
26.32Single8JJLOlodaterol8JJL-β2-Olodaterol
26.32Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
26.09Single3OE0CVX153OE0-CXCR4-CVX15
26.09Single5WF5UK-4320975WF5-A2A-UK-432097
26.09Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
26.09Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
26.09Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
26.09Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
26.09Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single8IY6Endothelin-18IY6-ETB-Endothelin-1
25.93Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.93Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.93Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
25.93Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
25.00Single3REYPubChem 56973REY-A2A-PubChem 5697
25.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
25.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
25.00Single5IU4ZM2413855IU4-A2A-ZM241385-Na
25.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
25.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
25.00Single5K2CZM2413855K2C-A2A-ZM241385-Na
25.00Single5NLXZM2413855NLX-A2A-ZM241385-Na
25.00Single5NM4ZM2413855NM4-A2A-ZM241385-Na
25.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
25.00Single6AQFZM2413856AQF-A2A-ZM241385
25.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
25.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
25.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
25.00Single7EZCUKA7EZC-A2A-UKA
25.00Single7T32ZM2413857T32-A2A-ZM241385
25.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
25.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
25.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
25.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
25.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
25.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
25.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
25.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
25.00Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
25.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
25.00Single8K2WAMG4878K2W-CXCR3-AMG487
25.00Single8K5CAcipimox8K5C-HCA2-Acipimox
25.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
25.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
25.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
25.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
25.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
25.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
25.00Consensusorexin_onOrthosteric Ligandox2_on
24.14Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
24.14Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
24.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
24.00Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
24.00Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single5WF6UK-4320975WF6-A2A-UK-432097
23.81Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
23.81Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
23.81Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
23.81Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
23.81Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
23.81Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
23.81Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
23.81Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.81Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
23.81Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
23.81Consensuslpl_offOrthosteric Ligands1p_off lpa_off
23.81Consensuslpl_onOrthosteric Ligands1p_on lpa_on
23.81Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
23.81Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
23.53Single3EMLZM2413853EML-A2A-ZM241385
23.53Single4EIYZM2413854EIY-A2A-ZM241385-Na
23.53Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
23.53Single5IU8Q274563475IU8-A2A-Q27456347-Na
23.53Single5K2AZM2413855K2A-A2A-ZM241385-Na
23.53Single5OLGZM2413855OLG-A2A-ZM241385-Na
23.53Single5UENDU1725UEN-A1-DU172
23.53Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
23.53Single5VRAZM2413855VRA-A2A-ZM241385-Na
23.53Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
23.53Single6S0LZM2413856S0L-A2A-ZM241385
23.53Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
23.53Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
23.53Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
23.53Single7PYRPSB-21157PYR-A2A-PSB-2115
23.53Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
23.53Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
23.53Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
23.53Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
23.53Single8CU6LJ-45178CU6-A2A-LJ-4517
23.53Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
23.53Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
23.53Single8K5DGSK2560738K5D-HCA2-GSK256073
23.53Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
23.53Consensusa2_offOrthosteric Liganda2a_off
23.53Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
23.53Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
23.53Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
23.53Consensusgi_hcarOrthosteric Ligandgi_hca
23.53Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
23.53Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
23.53Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
23.33Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
23.08Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
23.08Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
23.08Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single8A2OTheophylline8A2O-A2A-Theophylline-Na
23.08Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
23.08Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
22.73Single4IARErgotamine4IAR-5-HT1B-Ergotamine
22.73Single7F8XNN90567F8X-CCKA-NN9056
22.73Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
22.73Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
22.73Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
22.73Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
22.73Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
22.73Consensussst_onOrthosteric Ligandsst2_on sst4_on
22.73Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
22.58Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.58Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.58Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.58Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
22.22Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
22.22Single5N2SPSB365N2S-A1-PSB36
22.22Single5NM2ZM2413855NM2-A2A-ZM241385-Na
22.22Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
22.22Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
22.22Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
22.22Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
22.22Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
22.22Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
22.22Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
22.22Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
22.22Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
22.22Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.22Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.22Single7YXAONO-54306087YXA-S1P5-ONO-5430608
22.22Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
22.22Single8GNEKW-63568GNE-A2A-KW-6356-Na
22.22Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
22.22Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
22.22Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
22.22Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
22.22Consensusep_offOrthosteric Ligandep4_off
22.22Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Single3QAKUK-4320973QAK-A2A-UK-432097
21.74Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
21.74Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
21.74Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
21.74Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
21.74Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
21.74Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
21.74Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
21.74Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
21.43Single4XNWMRS25004XNW-P2Y1-MRS2500
21.43Single6LI0GTPL98046LI0-GPR52-GTPL9804
21.43Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
21.43Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
21.43Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
21.43Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
21.43Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
21.05Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
21.05Single5V56TC1145V56-SMO-TC114
21.05Single5V57TC1145V57-SMO-TC114
21.05Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
21.05Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
21.05Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
21.05Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
21.05Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
21.05Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
21.05Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
21.05Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
21.05Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.05Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
21.05Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
21.05Consensusadenosine_offOrthosteric Liganda1_off a2_off
21.05Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
21.05Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
21.05Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
21.05Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.05Consensuslpa_offOrthosteric Ligandlpa1_off
21.05Consensuslpa_onOrthosteric Ligandlpa1_on
21.05Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
20.83Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
20.83Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
20.83Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
20.83Single7XNACYN1548067XNA-SST2-CYN154806
20.83Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.83Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.83Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
20.83Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
20.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
20.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
20.00Single4N4WSANT-14N4W-SMO-SANT-1
20.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
20.00Single5L7IVismodegib5L7I-SMO-Vismodegib
20.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
20.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
20.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
20.00Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
20.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
20.00Single6MXTSalmeterol6MXT-β2-Salmeterol
20.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
20.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
20.00Single7K15MKD0467K15-BLT1-MKD046-Na
20.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
20.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
20.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
20.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
20.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
20.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
20.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
20.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
20.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
20.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
20.00Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
20.00Single8JWZAB9288JWZ-A2A-AB928-Na
20.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
20.00Single8K5BNiacin8K5B-HCA2-Niacin
20.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
20.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
20.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
20.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
20.00Consensusblt_offOrthosteric Ligandblt1_off
20.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
20.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
20.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
20.00Consensusclass-b2_onOrthosteric Ligandadgrg_on
20.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
20.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
20.00Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
20.00Consensusgo_proteinOrthosteric Ligandgo_chemokine
20.00Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.00Consensusgs_steroidOrthosteric Ligandgs_bileacid
20.00Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
20.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
20.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
20.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
19.23Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
19.23Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
19.23Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
19.05Single6IBLArformoterol6IBL-β1-Arformoterol
19.05Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
19.05Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
19.05Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
19.05Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.05Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
19.05Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
19.05Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
19.05Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
19.05Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
19.05Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
19.05Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
19.05Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
19.05Consensussteroid_onOrthosteric Ligandbileacid_on
18.75Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
18.75Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
18.75Single4BWBNeurotensin4BWB-NTS1-Neurotensin
18.75Single5K2DZM2413855K2D-A2A-ZM241385
18.75Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
18.75Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
18.75Single6JZHZM2413856JZH-A2A-ZM241385-Na
18.75Single6PS7ZM2413856PS7-A2A-ZM241385-Na
18.75Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
18.75Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
18.75Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
18.75Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
18.75Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
18.75Single7XRRLemborexant7XRR-OX2-Lemborexant
18.75Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
18.75Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
18.75Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
18.75Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
18.75Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
18.75Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
18.52Single6FJ3PTH6FJ3-PTH1-PTH
18.52Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
18.52Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
18.52Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
18.18Single6KNMJN241-96KNM-Apelin-JN241-9
18.18Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
18.18Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
18.18Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
18.18Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single7XN9L-054,5227XN9-SST2-L-054,522
18.18Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
18.18Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single8X5YAstemizole8X5Y-H1-Astemizole
18.18Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
18.18Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
18.18Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
18.18Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensusgs_class-b2Orthosteric Ligandgs_adgr
18.18Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
17.86Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.65Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
17.65Single5IU7Q274563465IU7-A2A-Q27456346-Na
17.65Single5JTBZM2413855JTB-A2A-ZM241385
17.65Single5UVIZM2413855UVI-A2A-ZM241385
17.65Single6DS0Ly2660976DS0-5-HT2B-Ly266097
17.65Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
17.65Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
17.65Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
17.65Single6ZG9GSK10347026ZG9-M1-GSK1034702
17.65Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
17.65Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
17.65Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
17.65Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
17.65Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
17.65Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
17.65Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
17.65Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
17.65Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
17.65Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
17.65Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
17.65Consensuss1p_offOrthosteric Ligands1p1_off
17.39Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
17.39Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
17.39Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
17.39Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
17.39Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
17.39Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
17.39Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
17.39Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
17.39Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
17.24Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
17.24Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
16.67Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
16.67Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
16.67Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
16.67Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
16.67Single6GPSMK08126GPS-CCR2-MK0812
16.67Single6IIVDaltroban6IIV-TP-Daltroban
16.67Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
16.67Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
16.67Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
16.67Single6TOTLemborexant6TOT-OX1-Lemborexant
16.67Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
16.67Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
16.67Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
16.67Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
16.67Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
16.67Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
16.67Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
16.67Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
16.67Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
16.67Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
16.67Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
16.67Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
16.67Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
16.67Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
16.67Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
16.67Consensusadenosine_onOrthosteric Liganda1_on a2_on
16.67Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
16.67Consensusblt_onOrthosteric Ligandblt1_on
16.67Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
16.67Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
16.67Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
16.67Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
16.67Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Consensusleuko_onOrthosteric Ligandblt_on
16.67Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
16.67Consensusnucleotide_onOrthosteric Ligandadenosine_on
16.67Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
16.67Consensussst_offOrthosteric Ligandsst2_off
16.67Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
16.67Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
16.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
16.00Single6PT2KGCHM076PT2-δ-KGCHM07
16.00Single6W25SHU91196W25-MC4-SHU9119-Ca
16.00Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
16.00Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
15.79Single2Y00Dobutamine2Y00-β1-Dobutamine
15.79Single5C1MBU725C1M-μ-BU72
15.79Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
15.79Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
15.79Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
15.79Single6GPXMK08126GPX-CCR2-MK0812
15.79Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
15.79Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
15.79Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
15.79Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
15.79Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
15.79Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
15.79Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
15.79Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
15.79Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
15.79Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
15.79Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
15.79Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
15.79Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
15.79Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
15.79Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
15.79Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
15.79Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
15.79Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
15.79Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
15.79Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
15.79Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
15.79Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
15.79Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
15.79Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
15.62Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
15.38Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
15.38Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
15.38Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
15.38Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
15.38Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
15.38Single8PWNTheophylline8PWN-A2A-Theophylline
15.38Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
15.38Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.38Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single3P0GBI1671073P0G-β2-BI167107
15.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
15.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
15.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
15.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
15.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
15.00Single5TZR-5TZR-FFA1 (GPR40)-MK8666
15.00Single5XR8AM8415XR8-CB1-AM841
15.00Single5XRAAM115425XRA-CB1-AM11542
15.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
15.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
15.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
15.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
15.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
15.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
15.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
15.00Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
15.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
15.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
15.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
15.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
15.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
15.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
15.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
15.00Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
15.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
15.00Single8E0GBU728E0G-μ-BU72
15.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
15.00Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
15.00Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
15.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
15.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
15.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
15.00Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
15.00Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
15.00Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
15.00Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
15.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
15.00Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
15.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
14.81Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
14.81Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
14.81Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
14.81Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
14.81Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
14.81Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
14.81Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
14.81Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.71Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
14.29Single3RFMCaffeine3RFM-A2A-Caffeine
14.29Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
14.29Single4XEENeurotensin4XEE-NTS1-Neurotensin
14.29Single4XESNeurotensin4XES-NTS1-Neurotensin
14.29Single5X33BIIL2605X33-BLT1-BIIL260
14.29Single6CM4Risperidone6CM4-D2-Risperidone
14.29Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
14.29Single6IIURamatroban6IIU-TP-Ramatroban
14.29Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
14.29Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
14.29Single6TQ9SB-4081246TQ9-OX1-SB-408124
14.29Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
14.29Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
14.29Single6YVRNTS8-136YVR-NTS1-NTS8-13
14.29Single6ZG4HTL00099366ZG4-M1-HTL0009936
14.29Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
14.29Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
14.29Single7DFPSpiperone7DFP-D2-Spiperone
14.29Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
14.29Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
14.29Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
14.29Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
14.29Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
14.29Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
14.29Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
14.29Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
14.29Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7YITNalfurafine7YIT-κ-Nalfurafine
14.29Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
14.29Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
14.29Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
14.29Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
14.29Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8JJ8Formoterol8JJ8-β2-Formoterol
14.29Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
14.29Single8WU1KCA8WU1-CB1-KCA-Arrestin1
14.29Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
14.29Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
14.29Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
14.29Consensusgi_class-fOther Ligandgi_frizzled
14.29Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
14.29Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
14.29Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
14.29Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
14.29Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
14.29Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
14.29Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
13.79Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
13.79Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
13.79Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
13.79Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.79Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
13.79Consensusgo_class-b1Orthosteric Ligandgo_crf
13.79Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
13.64Single4BUONeurotensin4BUO-NTS1-Neurotensin
13.64Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
13.64Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
13.64Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
13.64Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
13.64Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
13.64Single6H7LDobutamine6H7L-β1-Dobutamine
13.64Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
13.64Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
13.64Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
13.64Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
13.64Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
13.64Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
13.64Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
13.64Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
13.64Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
13.64Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
13.64Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
13.64Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
13.64Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
13.64Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
13.64Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
13.64Consensusendothelin_offOrthosteric Ligandetb_off
13.64Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
13.64Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
13.64Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
13.64Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
13.64Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
13.33Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
13.33Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
13.33Single6ME5Agomelatine6ME5-MT1-Agomelatine
13.33Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.33Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
13.33Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
13.33Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
13.33Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
13.33Single7WC5Psilocin7WC5-5-HT2A-Psilocin
13.33Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
13.33Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
13.33Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
13.33Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
13.33Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.04Single3NY9PubChem 9131033NY9-β2-PubChem 913103
13.04Single4UG2CGS216804UG2-A2A-CGS21680
13.04Single5EE7MK08935EE7-Glucagon-MK0893
13.04Single5ZTYAM102575ZTY-CB2-AM10257
13.04Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
13.04Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
13.04Single7SK9CCX6627SK9-ACKR3-CCX662
13.04Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
13.04Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
13.04Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
13.04Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.90Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
12.90Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
12.90Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
12.50Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
12.50Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.50Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
12.50Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
12.50Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
12.50Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
12.50Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
12.50Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
12.50Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
12.50Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
12.50Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
12.50Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
12.50Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
12.50Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8GH1Epinephrine8GH1-β2-Epinephrine
12.50Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
12.50Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
12.50Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusglp_onOrthosteric Ligandglp1_on glp2_on
12.50Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
12.12Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
12.12Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
12.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
12.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
12.00Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
12.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
11.76Single4QINSAG1.54QIN-SMO-SAG1.5
11.76Single4S0VSuvorexant4S0V-OX2-Suvorexant
11.76Single5DHHSB-6121115DHH-NOP-SB-612111
11.76Single5U09Taranabant5U09-CB1-Taranabant
11.76Single5WS3EMPA5WS3-OX2-EMPA
11.76Single6AKXA4R6AKX-CCR5-A4R
11.76Single6AKYMaraviroc6AKY-CCR5-Maraviroc
11.76Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
11.76Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.76Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
11.76Single6TPJSuvorexant6TPJ-OX2-Suvorexant
11.76Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.76Single7F8ULintitript7F8U-CCKA-Lintitript
11.76Single7F8YDevazepide7F8Y-CCKA-Devazepide
11.76Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.76Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
11.76Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
11.76Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
11.76Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
11.76Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
11.76Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
11.76Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
11.76Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.76Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
11.76Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
11.76Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
11.76Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
11.76Consensusclass-f_offOrthosteric Ligandsmo_off
11.76Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
11.76Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.76Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.76Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
11.76Consensusmglu_onOther Ligandmglu2_on mglu4_on
11.76Consensusorexin_offOrthosteric Ligandox2_off ox1_off
11.76Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
11.76Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.54Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
11.54Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
11.54Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
11.54Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.43Consensuspth_onOrthosteric Ligandpth1_on pth2_on
11.11Single2YDOAdenosine2YDO-A2A-Adenosine
11.11Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
11.11Single4MBSMaraviroc4MBS-CCR5-Maraviroc
11.11Single4ZJCSB-6740424ZJC-OX1-SB-674042
11.11Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
11.11Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
11.11Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
11.11Single6IQLL7458706IQL-D4-L745870
11.11Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
11.11Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
11.11Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
11.11Single6TP3Nemorexant6TP3-OX1-Nemorexant
11.11Single6TPGEMPA6TPG-OX2-EMPA
11.11Single6V9SGTPL114036V9S-OX1-GTPL11403
11.11Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
11.11Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
11.11Single6ZINSR486926ZIN-NTS1-SR48692
11.11Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
11.11Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
11.11Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
11.11Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
11.11Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
11.11Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.11Single8GGTEpinephrine8GGT-β2-Epinephrine
11.11Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
11.11Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
11.11Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
11.11Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.11Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
11.11Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
11.11Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
11.11Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
11.11Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
11.11Consensusgi_class-fOrthosteric Ligandgi_frizzled
11.11Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11Consensusgnrh_offOrthosteric Ligandgnrh1_off
11.11Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
11.11Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
11.11Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
11.11Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
10.81Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
10.81Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
10.81Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.71Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.71Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
10.53Single2Y01Dobutamine2Y01-β1-Dobutamine
10.53Single2Y02Carmoterol2Y02-β1-Carmoterol
10.53Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
10.53Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
10.53Single4YAYZD-71554YAY-AT1-ZD-7155
10.53Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
10.53Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
10.53Single5TGZAM65385TGZ-CB1-AM6538
10.53Single6DRXLisuride6DRX-5-HT2B-Lisuride
10.53Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
10.53Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
10.53Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
10.53Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
10.53Single6PS1Timolol6PS1-β2-Timolol
10.53Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
10.53Single7BU7BI1671077BU7-β1-BI167107
10.53Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
10.53Single7F83PF-051904577F83-Ghrelin-PF-05190457
10.53Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
10.53Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
10.53Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
10.53Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
10.53Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
10.53Single7UL4Alvimopan7UL4-μ-Alvimopan
10.53Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
10.53Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
10.53Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
10.53Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
10.53Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.53Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
10.53Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
10.53Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
10.53Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
10.53Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.53Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
10.53Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
10.53Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
10.53Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
10.53Consensuscck_offOrthosteric Ligandccka_off
10.53Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
10.53Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
10.53Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
10.53Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
10.53Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.53Consensushcar_offOrthosteric Ligandsuccinate_off
10.53Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
10.53Consensustar_onOrthosteric Ligandta1_on
10.34Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.34Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
10.34Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.34Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
10.34Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.34Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.00Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
10.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
10.00Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
10.00Single5WIUNemonapride5WIU-D4-Nemonapride
10.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
10.00Single5WQCEMPA5WQC-OX2-EMPA
10.00Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
10.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
10.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
10.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
10.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
10.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
10.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
10.00Single6TP6Filorexant6TP6-OX1-Filorexant
10.00Single6Z4SSR486926Z4S-NTS1-SR48692
10.00Single7C4SS1P7C4S-S1P3-S1P
10.00Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
10.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
10.00Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
10.00Single7SINNPS-21437SIN-CaS-NPS-2143
10.00Single7SINNPS-21437SIN-CaS-NPS-2143
10.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
10.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
10.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
10.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
10.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
10.00Single7XKAEpinephrine7XKA-β2-Epinephrine
10.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
10.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
10.00Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
10.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
10.00Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
10.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
10.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
10.00Single8QOTNanobody E8QOT-μ-Nanobody E
10.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
10.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
10.00Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
10.00Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
10.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
10.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
10.00Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
10.00Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
10.00Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
10.00Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
10.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
10.00Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
10.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
9.68Single6LMLGlucagon6LML-Glucagon-Glucagon
9.68Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.68Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
9.52Single2YDVNECA2YDV-A2A-NECA
9.52Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
9.52Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
9.52Single4BV0Neurotensin4BV0-NTS1-Neurotensin
9.52Single4DJHJDTic4DJH-κ-JDTic
9.52Single4UHRCGS216804UHR-A2A-CGS21680
9.52Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
9.52Single5G53NECA5G53-A2A-NECA-Gs
9.52Single5X93K-87945X93-ETB-K-8794
9.52Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
9.52Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
9.52Single6TQ7SB-3348676TQ7-OX1-SB-334867
9.52Single6WGTLSD6WGT-5-HT2A-LSD
9.52Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
9.52Single7EPENAM5637EPE-mGlu-NAM563
9.52Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
9.52Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
9.52Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
9.52Single7W41PD1762527W41-BB2-PD176252
9.52Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
9.52Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
9.52Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
9.52Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.52Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
9.52Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
9.52Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
9.52Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
9.52Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
9.52Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
9.52Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
9.52Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
9.52Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
9.52Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
9.52Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
9.52Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
9.52Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
9.52Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
9.52Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
9.52Consensusbombesin_offOrthosteric Ligandbb2_off
9.52Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
9.52Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
9.52Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
9.52Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
9.52Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
9.52Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
9.52Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
9.52Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
9.38Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
9.09Single4AMIBucindolol4AMI-β1-Bucindolol
9.09Single4LDEBI1671074LDE-β2-BI167107
9.09Single4PY02MeSATP4PY0-P2Y12-2MeSATP
9.09Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
9.09Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
9.09Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
9.09Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
9.09Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
9.09Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
9.09Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
9.09Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
9.09Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
9.09Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
9.09Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.09Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
9.09Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
9.09Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
9.09Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
9.09Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
9.09Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
9.09Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.09Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
9.09Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
9.09Consensusnts_offOrthosteric Ligandnts1_off
9.09Consensusnts_onOrthosteric Ligandnts1_on
9.09Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.09Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
8.82Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
8.70Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
8.70Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
8.70Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
8.70Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
8.70Single6K1QIRL25006K1Q-ETB-IRL2500
8.70Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
8.70Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
8.70Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
8.70Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
8.70Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
8.70Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
8.70Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
8.70Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
8.70Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
8.70Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
8.70Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
8.70Consensuscyslt_offOrthosteric Ligandcyslt2_off
8.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
8.33Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
8.33Single6PT3DPI-2876PT3-δ-DPI-287
8.33Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
8.33Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.33Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
8.33Consensusclass-d_offOrthosteric Ligandste2_off
8.11Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
8.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
8.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
8.00Single7QA8Peptide7QA8-STE2-Peptide
8.00Single7QA8Peptide7QA8-STE2-Peptide
8.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
8.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
8.00Consensusclass-d_offOrthosteric Ligandste2_off
7.69Single5MZPCaffeine5MZP-A2A-Caffeine-Na
7.69Single6HLOAprepitant6HLO-NK1-Aprepitant
7.69Single6W25Ca6W25-MC4-SHU9119-Ca
7.69Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.69Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
7.69Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
7.69Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
7.69Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
7.41Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
7.41Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
7.14Single7WC4Serotonin7WC4-5-HT2A-Serotonin
7.14Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
6.90Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
6.90Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
6.90Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
6.67Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
6.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
6.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
6.67Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
6.67Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
6.67Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Consensusclass-d_onOrthosteric Ligandste2_on
6.67Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
6.45Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
6.45Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
6.45Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
6.45Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.45Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
6.45Consensusgi_class-dOrthosteric Ligandgi_ste
6.45Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.45Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
6.25Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
6.25Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
6.25Single3UZAGTPL92363UZA-A2A-GTPL9236
6.25Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
6.25Single6ME9Ramelteon6ME9-MT2-Ramelteon
6.25Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
6.25Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
6.25Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
6.25Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
6.25Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
6.25Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
6.25Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
6.25Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
6.25Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
6.25Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
6.25Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
6.25Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
6.25Single8GGREpinephrine8GGR-β2-Epinephrine
6.25Single8GGZEpinephrine8GGZ-β2-Epinephrine
6.25Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
6.25Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
6.25Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
6.25Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
6.25Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
6.25Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
6.25Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
6.25Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
5.88Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
5.88Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
5.88Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
5.88Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
5.88Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
5.88Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
5.88Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.88Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.88Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
5.88Single7SRQLSD7SRQ-5-HT2B-LSD
5.88Single7UL2SR486927UL2-NTS1-SR48692-Na
5.88Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.88Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.88Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.88Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
5.88Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
5.88Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
5.88Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
5.88Single8GGSEpinephrine8GGS-β2-Epinephrine
5.88Single8GGYEpinephrine8GGY-β2-Epinephrine
5.88Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
5.88Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.88Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.88Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
5.88Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.88Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.88Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
5.88Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Consensusclass-t_onOrthosteric Ligandtaste2_on
5.88Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.88Consensusgo_class-b2Orthosteric Ligandgo_adhesion
5.88Consensusgs_class-tOrthosteric Ligandgs_taste
5.88Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.88Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.88Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
5.88Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
5.88Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
5.88Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
5.88Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.56Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
5.56Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
5.56Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
5.56Single6B73PubChem 1319551386B73-κ-PubChem 131955138
5.56Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
5.56Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
5.56Single6KUXRS-799486KUX-α2a-RS-79948
5.56Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
5.56Single6ME2Ramelteon6ME2-MT1-Ramelteon
5.56Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
5.56Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.56Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.56Single6TODEMPA6TOD-OX1-EMPA-Na
5.56Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
5.56Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
5.56Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
5.56Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.56Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.56Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.56Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.56Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.56Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.56Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
5.56Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
5.56Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
5.56Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
5.56Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.56Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
5.56Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
5.56Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
5.56Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
5.56Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
5.56Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
5.56Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
5.56Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
5.56Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56Single8GGVEpinephrine8GGV-β2-Epinephrine
5.56Single8GGWEpinephrine8GGW-β2-Epinephrine
5.56Single8GGXEpinephrine8GGX-β2-Epinephrine
5.56Single8GH0Epinephrine8GH0-β2-Epinephrine
5.56Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
5.56Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single8IWESpermidine8IWE-TAAR9-Spermidine
5.56Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
5.56Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.56Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
5.56Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.56Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.56Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
5.56Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.56Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
5.56Consensusalpha1_onOrthosteric Ligandalpha1a_on
5.56Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
5.56Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
5.56Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
5.56Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
5.56Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
5.56Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Consensusgt_class-aOrthosteric Ligandgt_opsin
5.56Consensusgt_opsinOrthosteric Ligandgt_sensory
5.56Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.56Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
5.56Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
5.26Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
5.26Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
5.26Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
5.26Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
5.26Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
5.26Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
5.26Single6PS4ICI 118-5516PS4-β2-ICI 118-551
5.26Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
5.26Single6VI4JDTic6VI4-κ-JDTic
5.26Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
5.26Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
5.26Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
5.26Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
5.26Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
5.26Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
5.26Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
5.26Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
5.26Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
5.26Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
5.26Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.26Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
5.26Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
5.26Single7VODCariprazine7VOD-5-HT2A-Cariprazine
5.26Single7VV6C48/807VV6-MRGPRX2-C48/80
5.26Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
5.26Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
5.26Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
5.26Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
5.26Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
5.26Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
5.26Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
5.26Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
5.26Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26Single8GGIEpinephrine8GGI-β2-Epinephrine
5.26Single8GGKEpinephrine8GGK-β2-Epinephrine
5.26Single8GGMEpinephrine8GGM-β2-Epinephrine
5.26Single8GGPEpinephrine8GGP-β2-Epinephrine
5.26Single8GGQEpinephrine8GGQ-β2-Epinephrine
5.26Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
5.26Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
5.26Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
5.26Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.26Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Consensus5ht5_onOrthosteric Ligand5ht5a_on
5.26Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
5.26Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
5.26Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
5.26Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
5.26Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
5.26Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
5.26Consensussensory_offOrthosteric Ligandopsin_off
5.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
5.00Single2Y04Salbutamol2Y04-β1-Salbutamol
5.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
5.00Single3NY8ICI 118-5513NY8-β2-ICI 118-551
5.00Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
5.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
5.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
5.00Single4DAJTiotropium4DAJ-M3-Tiotropium
5.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
5.00Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
5.00Single4MQSIperoxo4MQS-M2-Iperoxo
5.00Single4U14Tiotropium4U14-M3-Tiotropium
5.00Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
5.00Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
5.00Single5DSGTiotropium5DSG-M4-Tiotropium
5.00Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
5.00Single5T04Neurotensin5T04-NTS1-Neurotensin
5.00Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
5.00Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
5.00Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
5.00Single6H7MSalbutamol6H7M-β1-Salbutamol
5.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
5.00Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
5.00Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
5.00Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
5.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
5.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
5.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
5.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
5.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
5.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
5.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
5.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
5.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
5.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
5.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
5.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
5.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
5.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
5.00Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
5.00Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
5.00Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00Single8GGJEpinephrine8GGJ-β2-Epinephrine
5.00Single8GGNEpinephrine8GGN-β2-Epinephrine
5.00Single8GGOEpinephrine8GGO-β2-Epinephrine
5.00Single8GGUEpinephrine8GGU-β2-Epinephrine
5.00Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
5.00Single8JJOAlprenolol8JJO-β2-Alprenolol
5.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
5.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
5.00Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
5.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single8X63Mepyramine8X63-H1-Mepyramine
5.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
5.00Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
5.00Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
5.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
5.00Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
5.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
5.00Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
5.00Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
5.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
5.00Consensushistamine_onOrthosteric Ligandh1_on h4_on
5.00Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
5.00Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
5.00Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
4.88Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
4.76Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
4.76Single2Y03Isoprenaline2Y03-β1-Isoprenaline
4.76Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
4.76Single4NTJAZD12834NTJ-P2Y12-AZD1283
4.76Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
4.76Single5CGCHTL142425CGC-mGlu5-HTL14242
4.76Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
4.76Single5TVNLSD5TVN-5-HT2B-LSD
4.76Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
4.76Single5XPRBosentan5XPR-ETB-Bosentan
4.76Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
4.76Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
4.76Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
4.76Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
4.76Single6PS6Timolol6PS6-β2-Timolol
4.76Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.76Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
4.76Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
4.76Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
4.76Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
4.76Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
4.76Single7WC6LSD7WC6-5-HT2A-LSD
4.76Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
4.76Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single8EA0Iperoxo8EA0-M3-Iperoxo
4.76Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.76Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
4.76Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
4.76Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
4.76Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
4.76Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
4.76Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
4.76Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
4.76Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
4.76Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
4.76Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
4.76Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
4.76Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single4U15Tiotropium4U15-M3-Tiotropium
4.55Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
4.55Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
4.55Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
4.55Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
4.55Single6H7JIsoprenaline6H7J-β1-Isoprenaline
4.55Single6J21Aprepitant6J21-NK1-Aprepitant
4.55Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
4.55Single6OL9Tiotropium6OL9-M5-Tiotropium
4.55Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.55Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.55Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
4.55Single7P2L4YI7P2L-mGlu5-4YI
4.55Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
4.55Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
4.55Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
4.55Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
4.55Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.55Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
4.55Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Consensus5ht5_offOrthosteric Ligand5ht5a_off
4.55Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
4.55Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
4.55Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
4.55Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
4.55Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
4.55Consensushistamine_offOrthosteric Ligandh1_off
4.55Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
4.55Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
4.55Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.55Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
4.55Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
4.35Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
4.35Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
4.35Single5CXVTiotropium5CXV-M1-Tiotropium
4.35Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
4.35Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
4.35Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
4.35Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
4.35Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.35Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
4.35Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
4.17Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
4.17Single5CGDHTL142425CGD-mGlu5-HTL14242
4.17Single7UM4AS26747237UM4-5-HT5A-AS2674723
4.17Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
4.17Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
3.45Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
3.45Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.45Consensusclass-d_onOrthosteric Ligandste2_on
3.45Consensusgi_class-dOrthosteric Ligandgi_ste
3.45Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
2.38Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3

Consensus Members
Id Members
6WJC 6WJC-M1-Atropine-Muscarinic toxin 7
Net Summary
Imin 3.52
Number of Linked Nodes 267
Number of Links 308
Number of Hubs 42
Number of Links mediated by Hubs 168
Number of Communities 7
Number of Nodes involved in Communities 62
Number of Links involved in Communities 93
Path Summary
Number Of Nodes in MetaPath 73
Number Of Links MetaPath 72
Number of Shortest Paths 57611
Length Of Smallest Path 3
Average Path Length 13.3193
Length of Longest Path 32
Minimum Path Strength 1.2
Average Path Strength 7.49949
Maximum Path Strength 21.325
Minimum Path Correlation 0.7
Average Path Correlation 0.954644
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4.54545
Average % Of Corr. Nodes 62.478
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.7939
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
m1_off_ortoallom1_off_allom1_off



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