Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.H1.01 3.7625189
2G.S3.03 6.945508
3G.S3.04 7.85875417
4G.S3.06 8.743517
5G.H2.03 9.34625419
6G.H2.04 5.59625409
7G.H2.06 6.225619
8G.H2.07 7.532509
9G.h2s4.01 10.11409
10G.S4.02 5.284178
11G.s4h3.03 6.156254198
12G.H3.06 4.785406
13G.H3.09 5.088577109
14G.H3.13 12.2354106
15G.H3.17 9.00857715
16G.S5.04 5.301254109
17G.S5.05 4.8856119
18G.S5.06 3.881254158
19G.S5.07 4.5525409
20G.HG.01 6.028754156
21G.hgh4.02 4.5165128
22G.hgh4.05 10.422506
23G.H4.10 8.2215127
24G.H4.15 7.64108
25G.S6.02 10.0225208
26G.S6.05 10.81624155
27G.s6h5.01 5.8754119
28G.s6h5.05 4.1015119
29G.H5.08 4.83071798
30G.H5.15 3.3875408
31G.H5.23 6.7495214
32G.H5.25 4.58508
33b.1x2 4.8125402
34b.1x19 7.9075446
35b.b1x4 6.5175437
36b.l1x3 8.05571739
37b.l1x4 6.9025436
38b.l1x6 9.82419
39b.b2x1 6.27125418
40b.b2x5 6.82917637
41b.l3x1 7.69419
42b.l3x2 7.975439
43b.b4x5 4.438754227
44b.b4x6 11.76639
45b.l4x2 12.1025434
46b.b5x2 6.10625407
47b.b5x3 7.466539
48b.b5x5 4.55254225
49b.b5x7 6.5425407
50b.l5x1 5.1855238
51b.l5x5 8.86929719
52b.b6x1 4.72875419
53b.b6x5 4.255406
54b.l7x5 2.2425406
55b.b8x3 4.01625406
56b.b8x4 6.5875406
57b.l9x3 7.866589
58b.l9x6 6.78929718
59b.b10x5 6.085409
60b.l10x1 3.968503
61b.l10x4 8.511254243
62b.b11x4 4.95333689
63b.l11x2 7.503589
64b.b12x6 10.685588
65b.b13x7 8.144567
66b.l13x3 7.64917669
67b.l13x6 9.81419
68b.l13x7 4.287569
69b.b15x2 7.05446
70b.b15x5 4.495468
71b.l15x1 6.585417
72b.l15x2 6.09125469
73b.b16x4 10.3425466
74b.b16x5 5.992545
75b.b16x6 7.90214768
76b.b16x7 7.765449
77b.b17x5 6.94547
78b.b17x7 10.2262448
79b.l17x3 9.13833649
80b.l17x6 9.26875419
81b.b18x3 4.89875448
82b.l18x1 7.48583676
83b.l18x2 6.0225477
84b.l18x3 8.58875475
85b.b19x2 7.657546
86b.b19x4 6.57875448
87b.l19x1 6.7419
88b.l19x2 8.33549
89b.b20x4 10.073548
90b.b20x6 6.81083646
91b.b20x7 5.03417679
92b.l20x2 9.66625479
93b.b21x1 8.638547
94b.b21x2 3.81406
95b.b21x5 6.32375404
96b.b21x7 7.38505
97b.l21x9 5.52875406
98b.b22x5 5.1125677
99b.l22x5 6.3055139
100b.b23x6 6.83214717
101b.b24x2 5.91375415
102b.b24x3 3.71125455
103b.b24x4 6.46375416
104b.l25x3 9.015559
105b.l25x6 13.696518
106b.b26x3 3.86456
107b.l27x5 5.82625435
108b.b27x3 6.1075458
109b.l28x1 9.85083619
110b.l28x2 8.9225459
111b.b28x3 4.76407
112b.b28x4 8.775456
113b.b28x6 10.304559
114b.b28x7 5.1775439
115Lig 19.20852320
116g.l1x2 4.12375442
117g.h2x11 8.20125476
118g.ctx3 6.5465149
119g.ctx4 4.10875407
120g.ctx6 2.88754146
121g.ctx14 5.90875439
122g.ctx16 6.05929738
1231x43 5.928754267
1241x50 6.16875409
1251x54 1.41407
1262x38 5.688754217
1272x42 6.183508
1282x54 4.166437266
129E1x50 6.799527
130E1x52 5.095406
1313x30 5.9645296
1323x33 10.7138424
1333x37 8.25375426
1343x49 7.084219
1353x51 8.695408
136I2x51 4.28625497
1374x50 5.945409
138E2 29.875924
1395x46 6.18875426
1405x54 5.94754168
1415x58 7.2345169
1426x44 6.7425409
1436x48 7.4425288
1446x55 12.2787426
145E3 8.90187823
1467x38 8.30625425
1477x40 2.6475407
1487x52 2.915408
1497x53 5.0275409
1508x50 7.98254278
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1G.H3.16 G.H3.17 18.507213.995NoYes055
2G.H3.16 G.h3s5.01 18.56245.865NoNo053
3G.h3s5.01 G.h4s6.12 18.61785.33NoNo032
4G.h4s6.10 G.h4s6.12 18.673414.295NoNo032
5G.h4s6.08 G.h4s6.10 18.84798.83NoNo053
6G.H3.13 G.h4s6.08 19.08056.18YesNo065
7G.H3.13 G.h4s6.13 99.702325.39YesNo067
8G.S5.01 G.h4s6.13 99.7452.09NoNo087
9G.S5.01 G.S6.02 99.74184.455NoYes2088
10G.H5.10 G.S6.02 10013.79NoYes078
11G.H5.10 G.S5.03 49.790412.59NoNo079
12G.S5.03 G.S5.05 49.7863.77NoYes099
13G.H5.07 G.S5.05 97.44855.02NoYes099
14G.H5.07 G.S4.03 97.39633.68NoNo097
15G.S1.04 G.S4.03 97.34416.425NoNo077
16G.S1.04 G.S3.03 97.29174.26NoYes078
17G.S3.01 G.S3.03 87.30375.245NoYes058
18G.H5.08 G.S3.01 43.86373.275YesNo985
19G.H5.08 G.H5.12 43.42673.72YesNo987
20G.H5.12 I2x50 86.65195.02NoNo078
21G.H5.16 I2x50 86.48263.285NoNo068
22G.H5.16 G.H5.20 86.31383.46NoNo068
23G.H5.20 G.H5.25 85.24065.535NoYes088
243x50 G.H5.25 42.35356.68NoYes098
253x50 5x58 42.63756.69NoYes099
26G.H5.10 G.S6.04 50.25199.45NoNo079
27G.S5.05 G.S6.04 49.74195.66YesNo1199
28G.S3.01 I2x51 43.39314.47NoYes957
29G.H5.12 I2x51 43.39473.525NoYes977
306x37 G.H5.25 42.29244.15NoYes088
315x58 6x37 42.11198.79YesNo098
32G.S1.05 G.h2s4.01 40.978917.66NoYes099
33G.H2.04 G.S1.07 34.97666.075YesNo098
34G.S1.05 G.S4.02 41.03218.565NoYes1798
35G.s3h2.03 b.l9x6 10.20468.455NoYes098
36G.s3h2.03 b.l7x4 18.86847.26NoNo099
37G.H2.07 b.l9x6 60.52859.165YesYes098
38G.H2.07 G.h2s4.01 35.50325.51YesYes099
39G.H2.06 b.l9x6 36.36163.58YesYes198
40G.H2.06 b.l19x1 34.92345.53YesYes199
41G.S4.02 G.S5.02 76.22433.84YesNo086
42G.H3.09 G.H3.13 82.1975.01YesYes1096
43G.H3.09 G.S5.02 76.27373.93YesNo096
44G.H3.17 b.l23x1 10.10346.7YesNo156
45b.l17x5 b.l19x1 34.78025.155NoYes069
46b.l17x5 b.l19x2 34.57613.68NoYes069
47b.l17x3 b.l19x2 24.04456.3YesYes499
48b.b19x4 b.l17x3 13.71798.21YesYes489
49b.b17x7 b.b20x6 24.073515.005YesYes486
50b.b17x7 b.b21x1 20.91865.375YesYes487
51b.1x19 b.b21x1 18.409514.885YesYes467
52b.1x15 b.1x19 15.24336.26NoYes076
53b.1x15 g.h1x11 12.7064.28NoNo079
54b.1x11 g.h1x11 11.43693.46NoNo089
55b.b20x4 b.b20x6 17.73374.275YesYes486
56b.l21x7 b.l23x1 11.52533.11NoNo156
57b.b23x6 b.l21x7 10.79894.03YesNo175
58b.b10x1 b.l9x6 18.88083.18NoYes098
59b.b10x1 b.b11x5 18.67343.26NoNo096
60b.b11x5 b.b14x3 11.51435.255NoNo065
61b.l7x4 b.l9x5 17.66035.09NoNo098
62b.l11x2 b.l9x5 17.2614.195YesNo098
63b.l11x2 b.l9x3 15.26625.67YesYes899
64b.b12x6 b.l9x3 10.43998.46YesYes889
656x55 Lig 51.322722.37YesYes260
666x51 6x55 58.181610.69NoYes066
676x48 6x51 69.33328.02YesNo086
686x44 6x48 75.489615.035YesYes098
695x54 6x44 76.12484.265YesYes089
705x54 5x58 76.307510.55YesYes1689
71E3 Lig 11.38775.785YesYes230
722x67 Lig 10.208814.375NoYes230
73E2x51 Lig 10.20923.94NoYes230
744x50 4x54 11.78799.02YesNo094
753x30 4x54 12.96677.5YesNo2964
763x30 4x62 18.862511.255YesNo065
773x26 4x62 20.04133.72NoNo075
783x22 3x26 22.398712.445NoNo047
793x22 E2 23.577113.79NoYes244
806x51 6x52 10.99496.79NoNo067
81G.H2.04 G.H2.07 34.67496YesYes099
82G.S1.07 G.S4.02 35.04363.565NoYes1788
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
3x29Lig21.852NoYes4010
7x34Lig16.6752NoYes4010
7x37Lig3.220NoYes7010
7x38Lig12.6052YesYes5010
6x58Lig14.6252NoYes4010
LigNT11.342YesNo0401
2x63Lig3.7852NoYes5010
2x64Lig5.6550NoYes4010
7x31Lig12.672NoYes3010
6x61Lig5.22NoYes2010
E3Lig5.7852YesYes3010
2x67Lig14.3752NoYes3010
E2x51Lig3.942NoYes3010
7x31NT6.682NoNo3411
7x35NT6.70NoNo4421
2x607x385.972NoYes6511
2x63E1x5072NoYes5712
2x67E212.3452NoYes3412
E1x50E25.422YesYes7422
3x283x294.0950NoNo4421
3x294x655.7352NoNo4412
3x333x3710.12YesYes4612
3x334x616.152YesNo4411
3x336x558.1452YesYes4611
3x33Lig18.462YesYes4010
3x375x436.362YesNo6622
4x61Lig8.4552NoYes4010
4x645x395.6552NoNo4511
E2E297.652YesYes4422
E2E2x5116.2852YesNo4321
E2E313.112YesYes4321
5x39Lig8.712NoYes5010
5x436x557.910NoYes6621
6x516x5510.690NoYes6621
6x55Lig22.372YesYes6010
6x58E37.52NoYes4311
6x60E311.8750NoYes4321
6x61E33.532NoYes2311
E3E313.0452YesYes3311
7x387x4211.862YesNo5712
2x60Lig5.072NoYes6010
4x64Lig6.492NoYes4010
E2x52Lig4.210NoYes4010
7x28E33.3252NoYes1321
7x307x342.980NoNo4421
1x397x382.790NoYes6521
2x622x632.6150NoNo4521
6x547x342.5450NoNo4421
7x27Lig2.3050NoYes3010
4x634x640.7450NoNo4421

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
78.26Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
76.19Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
68.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
60.71Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
55.17Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
55.17Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
54.17Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
53.85Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
53.85Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
53.12Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
51.85Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
51.72Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
50.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
50.00Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
48.48Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
48.39Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
48.28Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
48.15Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
48.00Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
48.00Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
46.43Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
46.43Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.15Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
46.15Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
45.83Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
45.45Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
44.83Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
44.44Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
44.44Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
44.44Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
44.12Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
44.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
43.48Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
43.48Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
43.33Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
43.33Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
43.33Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
43.33Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
43.33Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
43.33Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
43.33Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
42.86Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
42.86Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
42.31Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
42.31Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
42.31Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
41.94Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
41.94Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
41.67Single6OS1TRV0266OS1-AT1-TRV026
41.67Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.67Consensuscck_onOrthosteric Ligandccka_on cckb_on
41.67Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
41.38Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
40.74Single7F8XNN90567F8X-CCKA-NN9056
40.74Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
40.74Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
40.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
40.00Single4XESNeurotensin4XES-NTS1-Neurotensin
40.00Single6OS2TRV0266OS2-AT1-TRV026
40.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
40.00Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
40.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
40.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
40.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
40.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
39.39Single5GLHEndothelin-15GLH-ETB-Endothelin-1
39.39Single6IGKEndothelin-36IGK-ETB-Endothelin-3
39.29Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
39.29Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
39.29Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
39.29Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
39.29Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
39.13Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
39.13Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
39.13Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
38.71Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Single4BUONeurotensin4BUO-NTS1-Neurotensin
38.46Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
38.46Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
38.46Consensusorexin_onOrthosteric Ligandox2_on
38.24Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
38.10Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
37.93Single3OE0CVX153OE0-CXCR4-CVX15
37.93Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
37.93Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
37.93Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
37.93Consensusangiotensin_onOrthosteric Ligandat1_on
37.93Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
37.93Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
37.93Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
37.50Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
37.50Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
37.14Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
37.04Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
37.04Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
37.04Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
37.04Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.04Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
37.04Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
37.04Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.04Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
37.04Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
36.67Single6JODAngiotensin II6JOD-AT2-Angiotensin II
36.67Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
36.67Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
36.67Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
36.67Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
36.36Single6IGLIRL16206IGL-ETB-IRL1620
36.36Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
36.36Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
36.11Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
36.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
36.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
36.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
36.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
36.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
36.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
36.00Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
36.00Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.71Single4XT1Fractalkine4XT1-US28-Fractalkine
35.71Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
35.71Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
35.71Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
35.71Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
35.71Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
35.48Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
35.48Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.48Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
35.48Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
35.48Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.48Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
35.48Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
34.78Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
34.78Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
34.78Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
34.78Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
34.62Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
34.62Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
34.62Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
34.62Single6YVRNTS8-136YVR-NTS1-NTS8-13
34.62Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
34.62Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.62Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.62Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
34.62Consensuschemokine_offOrthosteric Ligandcxcr_off
34.62Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
34.62Consensuscxcr_offOrthosteric Ligandcxcr4_off
34.62Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
34.62Consensusdp_offOrthosteric Liganddp2_off
34.48Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
34.48Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
34.48Single7SK5CXCL127SK5-ACKR3-CXCL12
34.48Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
34.48Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
34.38Single4XT3Fractalkine4XT3-US28-Fractalkine
34.38Single7SK3CXCL127SK3-ACKR3-CXCL12
34.38Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
34.38Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
34.29Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
33.33Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
33.33Single6W25SHU91196W25-MC4-SHU9119-Ca
33.33Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
33.33Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
33.33Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
33.33Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
33.33Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
33.33Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
33.33Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
33.33Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
33.33Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
33.33Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
33.33Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
33.33Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
33.33Consensusendothelin_onOrthosteric Ligandetb_on eta_on
33.33Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
33.33Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
33.33Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
33.33Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
33.33Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
32.35Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
32.35Single8IY6Endothelin-18IY6-ETB-Endothelin-1
32.35Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
32.26Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
32.26Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
32.26Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
32.14Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
32.14Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
32.14Single7XN9L-054,5227XN9-SST2-L-054,522
32.14Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
32.14Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
32.14Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
32.14Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
32.14Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
32.14Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
31.82Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
31.82Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
31.82Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
31.43Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
31.43Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
31.25Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
31.25Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
31.25Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
31.25Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
31.03Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
31.03Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
31.03Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.03Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
31.03Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
31.03Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.03Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
31.03Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
31.03Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
31.03Consensussst_onOrthosteric Ligandsst2_on sst4_on
30.95Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
30.77Single4BV0Neurotensin4BV0-NTS1-Neurotensin
30.77Single7F1TMIP-1a7F1T-CCR5-MIP-1a
30.77Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
30.77Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
30.77Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
30.77Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
30.77Consensuschemerin_onOrthosteric Ligandcml1_on
30.77Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
30.77Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
30.77Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensusrelaxin_onOrthosteric Ligandrxfp4_on
30.56Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
30.56Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
30.43Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
30.43Single7F8YDevazepide7F8Y-CCKA-Devazepide
30.43Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
30.30Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
30.30Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.30Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.30Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
30.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
30.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
30.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
30.00Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
30.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
29.63Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
29.63Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
29.63Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
29.63Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
29.63Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
29.63Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
29.63Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
29.63Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
29.63Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
29.63Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
29.63Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
29.63Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
29.63Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
29.63Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
29.63Consensusnts_offOrthosteric Ligandnts1_off
29.63Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
29.63Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
29.41Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
29.17Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
29.17Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
29.17Single6ZINSR486926ZIN-NTS1-SR48692
29.17Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
29.17Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
29.17Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
29.17Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
29.03Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
29.03Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
29.03Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
29.03Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
29.03Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
29.03Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
28.57Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
28.57Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
28.57Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
28.57Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
28.57Single7EZCUKA7EZC-A2A-UKA
28.57Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
28.57Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
28.57Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
28.57Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
28.57Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
28.57Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.12Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
28.12Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
28.12Single7C61Ergotamine7C61-5-HT1B-Ergotamine
28.12Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.12Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
28.12Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.12Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
28.00Single4YAYZD-71554YAY-AT1-ZD-7155
28.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
28.00Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
28.00Single6D27CAY104716D27-DP2-CAY10471
28.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
28.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
28.00Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
28.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
28.00Single8K5DGSK2560738K5D-HCA2-GSK256073
28.00Consensuscck_offOrthosteric Ligandccka_off
28.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
28.00Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
28.00Consensusgi_hcarOrthosteric Ligandgi_hca
28.00Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
28.00Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
28.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
27.59Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
27.59Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
27.59Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
27.59Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
27.59Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
27.59Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
27.59Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.59Consensuslpl_offOrthosteric Ligands1p_off lpa_off
27.59Consensuslpl_onOrthosteric Ligands1p_on lpa_on
27.27Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
27.27Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
27.27Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
27.27Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
27.27Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
27.27Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
27.27Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
27.27Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
27.27Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Single5N2SPSB365N2S-A1-PSB36
26.92Single6D26Fevipiprant6D26-DP2-Fevipiprant
26.92Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
26.92Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
26.92Single6Z4SSR486926Z4S-NTS1-SR48692
26.92Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
26.92Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
26.92Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
26.92Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.92Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.92Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.92Single8GNEKW-63568GNE-A2A-KW-6356-Na
26.92Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.92Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
26.67Single4IARErgotamine4IAR-5-HT1B-Ergotamine
26.67Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
26.67Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
26.67Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
26.67Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
26.67Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
26.67Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
26.47Single6FJ3PTH6FJ3-PTH1-PTH
26.47Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
26.47Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Single3OE9IT1t3OE9-CXCR4-IT1t
25.93Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
25.93Single4RWADIPP-NH24RWA-δ-DIPP-NH2
25.93Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
25.93Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
25.93Single7B6WCyclazosin7B6W-α1b-Cyclazosin
25.93Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
25.93Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
25.93Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
25.93Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
25.93Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.93Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single8E0GBU728E0G-μ-BU72
25.93Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
25.93Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
25.93Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
25.93Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
25.93Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
25.93Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
25.93Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
25.81Single3QAKUK-4320973QAK-A2A-UK-432097
25.81Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
25.81Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
25.81Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
25.81Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.81Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
25.81Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
25.81Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
25.81Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
25.81Consensussst_offOrthosteric Ligandsst2_off
25.71Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
25.64Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
25.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
25.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
25.00Single5WF5UK-4320975WF5-A2A-UK-432097
25.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
25.00Single6MXTSalmeterol6MXT-β2-Salmeterol
25.00Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
25.00Single6PT2KGCHM076PT2-δ-KGCHM07
25.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
25.00Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7F8ULintitript7F8U-CCKA-Lintitript
25.00Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
25.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
25.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
25.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
25.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Single7XNACYN1548067XNA-SST2-CYN154806
25.00Single7XRRLemborexant7XRR-OX2-Lemborexant
25.00Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
25.00Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
25.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
25.00Single8JJLOlodaterol8JJL-β2-Olodaterol
25.00Single8JWZAB9288JWZ-A2A-AB928-Na
25.00Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
25.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
25.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
25.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
25.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
25.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
25.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
25.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
25.00Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
25.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
25.00Consensusnts_onOrthosteric Ligandnts1_on
25.00Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
25.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
24.32Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
24.32Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
24.24Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
24.24Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
24.24Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
24.24Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
24.24Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
24.24Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
24.14Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
24.14Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
24.14Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
24.14Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
24.14Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
24.14Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
24.14Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
24.00Single3REYPubChem 56973REY-A2A-PubChem 5697
24.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
24.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
24.00Single5NLXZM2413855NLX-A2A-ZM241385-Na
24.00Single6MH8ZM2413856MH8-A2A-ZM241385
24.00Single6V9SGTPL114036V9S-OX1-GTPL11403
24.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
24.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
24.00Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
24.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
24.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
24.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
24.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
24.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
24.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
24.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
24.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
24.00Consensuss1p_offOrthosteric Ligands1p1_off
23.81Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
23.68Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
23.53Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
23.53Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
23.33Single4UG2CGS216804UG2-A2A-CGS21680
23.33Single5WF6UK-4320975WF6-A2A-UK-432097
23.33Single5ZTYAM102575ZTY-CB2-AM10257
23.33Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
23.33Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
23.33Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
23.33Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
23.33Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
23.33Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
23.08Single3EMLZM2413853EML-A2A-ZM241385
23.08Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
23.08Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
23.08Single5K2AZM2413855K2A-A2A-ZM241385-Na
23.08Single5T04Neurotensin5T04-NTS1-Neurotensin
23.08Single5VRAZM2413855VRA-A2A-ZM241385-Na
23.08Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
23.08Single6LPJZM2413856LPJ-A2A-ZM241385-Na
23.08Single6LPKZM2413856LPK-A2A-ZM241385-Na
23.08Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
23.08Single6S0LZM2413856S0L-A2A-ZM241385
23.08Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
23.08Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
23.08Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
23.08Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
23.08Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
23.08Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
23.08Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
23.08Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
23.08Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
23.08Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
23.08Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
23.08Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
23.08Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
23.08Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
22.86Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
22.86Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
22.86Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
22.86Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
22.86Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
22.86Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
22.58Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
22.58Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
22.58Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
22.58Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
22.58Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
22.58Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
22.58Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
22.58Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
22.58Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
22.58Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
22.50Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
22.50Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
22.50Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
22.22Single5C1MBU725C1M-μ-BU72
22.22Single5IUAQ274563485IUA-A2A-Q27456348-Na
22.22Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
22.22Single5NM2ZM2413855NM2-A2A-ZM241385-Na
22.22Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
22.22Single6LPLZM2413856LPL-A2A-ZM241385-Na
22.22Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
22.22Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
22.22Single6S0QZM2413856S0Q-A2A-ZM241385
22.22Single6WQAZM2413856WQA-A2A-ZM241385-Na
22.22Single7C4SS1P7C4S-S1P3-S1P
22.22Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
22.22Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
22.22Single7RM5ZM2413857RM5-A2A-ZM241385-Na
22.22Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
22.22Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
22.22Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
22.22Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
22.22Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
22.22Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.22Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.22Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
22.22Single8FYNZM2413858FYN-A2A-ZM241385-Na
22.22Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
22.22Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.22Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
22.22Single8QOTNanobody E8QOT-μ-Nanobody E
22.22Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
22.22Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
22.22Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.95Consensuspth_onOrthosteric Ligandpth1_on pth2_on
21.88Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
21.88Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
21.88Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
21.74Single3OE6IT1t3OE6-CXCR4-IT1t
21.74Single3OE8IT1t3OE8-CXCR4-IT1t
21.74Single4XNWMRS25004XNW-P2Y1-MRS2500
21.74Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
21.62Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
21.62Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
21.62Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
21.43Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
21.43Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
21.43Single5XR8AM8415XR8-CB1-AM841
21.43Single5XRAAM115425XRA-CB1-AM11542
21.43Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
21.43Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
21.43Single6TQ7SB-3348676TQ7-OX1-SB-334867
21.43Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
21.43Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
21.43Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
21.43Single7PX4PSB-21137PX4-A2A-PSB-2113
21.43Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
21.43Single7TUYGSK682753A7TUY-GPR183-GSK682753A
21.43Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
21.43Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
21.43Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.43Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
21.43Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
21.43Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
21.43Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
21.43Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
21.43Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
21.43Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
21.43Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
21.43Consensus5ht5_offOrthosteric Ligand5ht5a_off
21.43Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
21.43Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.43Consensuslpa_offOrthosteric Ligandlpa1_off
21.43Consensuslpa_onOrthosteric Ligandlpa1_on
21.43Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
21.43Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
21.43Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
21.21Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.93Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
20.93Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
20.83Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
20.83Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
20.83Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
20.83Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
20.83Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
20.83Single8GH1Epinephrine8GH1-β2-Epinephrine
20.69Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
20.69Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
20.69Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
20.69Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
20.69Single7K15MKD0467K15-BLT1-MKD046-Na
20.69Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
20.69Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
20.69Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
20.69Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
20.69Single7YITNalfurafine7YIT-κ-Nalfurafine
20.69Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
20.69Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
20.69Single8WU1KCA8WU1-CB1-KCA-Arrestin1
20.69Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
20.69Consensusblt_offOrthosteric Ligandblt1_off
20.69Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
20.69Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
20.69Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.69Consensusgs_steroidOrthosteric Ligandgs_bileacid
20.69Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
20.69Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
20.69Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
20.69Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
20.69Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
20.59Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
20.59Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
20.59Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
20.59Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
20.51Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
20.51Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
20.51Consensusglp_onOrthosteric Ligandglp1_on glp2_on
20.45Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
20.00Single3ODUIT1t3ODU-CXCR4-IT1t
20.00Single3PWHZM2413853PWH-A2A-ZM241385
20.00Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
20.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
20.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
20.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
20.00Single5K2DZM2413855K2D-A2A-ZM241385
20.00Single5WS3EMPA5WS3-OX2-EMPA
20.00Single6IBLArformoterol6IBL-β1-Arformoterol
20.00Single6JZHZM2413856JZH-A2A-ZM241385-Na
20.00Single6PS7ZM2413856PS7-A2A-ZM241385-Na
20.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
20.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
20.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
20.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
20.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
20.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.00Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
20.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
20.00Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
20.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
20.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
20.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
20.00Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
20.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
20.00Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
20.00Single8IHKAcifran8IHK-HCA3-Acifran
20.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
20.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
20.00Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.00Consensusendothelin_offOrthosteric Ligandetb_off
20.00Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
20.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
20.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
20.00Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
20.00Consensussteroid_onOrthosteric Ligandbileacid_on
20.00Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
19.51Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
19.44Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
19.44Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
19.44Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
19.44Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
19.35Single6KNMJN241-96KNM-Apelin-JN241-9
19.35Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.35Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
19.35Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
19.23Single4ZJCSB-6740424ZJC-OX1-SB-674042
19.23Single5IU4ZM2413855IU4-A2A-ZM241385-Na
19.23Single5IU7Q274563465IU7-A2A-Q27456346-Na
19.23Single5IUBQ274563445IUB-A2A-Q27456344-Na
19.23Single5JTBZM2413855JTB-A2A-ZM241385
19.23Single5K2CZM2413855K2C-A2A-ZM241385-Na
19.23Single5NM4ZM2413855NM4-A2A-ZM241385-Na
19.23Single5UVIZM2413855UVI-A2A-ZM241385
19.23Single6DS0Ly2660976DS0-5-HT2B-Ly266097
19.23Single6IQLL7458706IQL-D4-L745870
19.23Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
19.23Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
19.23Single6TP3Nemorexant6TP3-OX1-Nemorexant
19.23Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
19.23Single7AROLUF58337ARO-A2A-LUF5833-Na
19.23Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
19.23Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.23Single7T32ZM2413857T32-A2A-ZM241385
19.23Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
19.23Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
19.23Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
19.23Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
19.23Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
19.23Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
19.23Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
19.23Single8K5CAcipimox8K5C-HCA2-Acipimox
19.23Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.23Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
19.23Consensushca_onOrthosteric Ligandhca2_on hca3_on
19.23Consensushcar_onOrthosteric Ligandhca_on
19.23Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
19.23Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
19.05Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
18.92Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
18.92Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
18.92Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
18.92Consensusgo_class-b1Orthosteric Ligandgo_crf
18.92Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.92Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
18.75Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
18.75Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
18.75Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
18.52Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
18.52Single2Y02Carmoterol2Y02-β1-Carmoterol
18.52Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
18.52Single4EIYZM2413854EIY-A2A-ZM241385-Na
18.52Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
18.52Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
18.52Single5IU8Q274563475IU8-A2A-Q27456347-Na
18.52Single5OLGZM2413855OLG-A2A-ZM241385-Na
18.52Single6DRXLisuride6DRX-5-HT2B-Lisuride
18.52Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
18.52Single6PS1Timolol6PS1-β2-Timolol
18.52Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
18.52Single6TOTLemborexant6TOT-OX1-Lemborexant
18.52Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
18.52Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
18.52Single7PYRPSB-21157PYR-A2A-PSB-2115
18.52Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
18.52Single7UL4Alvimopan7UL4-μ-Alvimopan
18.52Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
18.52Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
18.52Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
18.52Single8CU6LJ-45178CU6-A2A-LJ-4517
18.52Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
18.52Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
18.52Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
18.52Consensusa2_offOrthosteric Liganda2a_off
18.52Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
18.52Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
18.52Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
18.52Consensusblt_onOrthosteric Ligandblt1_on
18.52Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
18.52Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
18.52Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
18.52Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
18.52Consensushcar_offOrthosteric Ligandsuccinate_off
18.52Consensusleuko_onOrthosteric Ligandblt_on
18.52Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
18.52Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
18.52Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
18.52Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
18.42Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
18.42Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
18.42Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
18.42Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
18.42Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.42Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
18.42Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
18.18Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
18.18Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
18.18Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
17.95Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
17.95Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
17.95Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
17.95Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.86Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
17.86Single4NTJAZD12834NTJ-P2Y12-AZD1283
17.86Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
17.86Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
17.86Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
17.86Single5TVNLSD5TVN-5-HT2B-LSD
17.86Single5WQCEMPA5WQC-OX2-EMPA
17.86Single5XPRBosentan5XPR-ETB-Bosentan
17.86Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
17.86Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
17.86Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
17.86Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
17.86Single6PS6Timolol6PS6-β2-Timolol
17.86Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
17.86Single6TP6Filorexant6TP6-OX1-Filorexant
17.86Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
17.86Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
17.86Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
17.86Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
17.86Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
17.86Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
17.86Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
17.86Single7XKAEpinephrine7XKA-β2-Epinephrine
17.86Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
17.86Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
17.86Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
17.86Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
17.86Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.86Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
17.86Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
17.86Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
17.86Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
17.86Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
17.65Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
17.50Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
17.50Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
17.39Single3RFMCaffeine3RFM-A2A-Caffeine
17.39Single6TQ9SB-4081246TQ9-OX1-SB-408124
17.39Single8A2OTheophylline8A2O-A2A-Theophylline-Na
17.24Single3P0GBI1671073P0G-β2-BI167107
17.24Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
17.24Single4DJHJDTic4DJH-κ-JDTic
17.24Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
17.24Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
17.24Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
17.24Single5TZR-5TZR-FFA1 (GPR40)-MK8666
17.24Single5V56TC1145V56-SMO-TC114
17.24Single5X93K-87945X93-ETB-K-8794
17.24Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
17.24Single6H7JIsoprenaline6H7J-β1-Isoprenaline
17.24Single6J20Aprepitant6J20-NK1-Aprepitant
17.24Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
17.24Single6WGTLSD6WGT-5-HT2A-LSD
17.24Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
17.24Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
17.24Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
17.24Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
17.24Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
17.24Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
17.24Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
17.24Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
17.24Single7W41PD1762527W41-BB2-PD176252
17.24Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
17.24Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
17.24Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
17.24Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
17.24Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
17.24Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
17.24Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
17.24Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
17.24Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Consensusadenosine_offOrthosteric Liganda1_off a2_off
17.24Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
17.24Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
17.24Consensusbombesin_offOrthosteric Ligandbb2_off
17.24Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
17.24Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
17.24Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
17.24Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
17.24Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
17.24Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
17.24Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
17.14Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
17.14Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
17.07Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
17.07Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
17.07Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
17.02Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
16.67Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
16.67Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
16.67Single4AMIBucindolol4AMI-β1-Bucindolol
16.67Single4LDEBI1671074LDE-β2-BI167107
16.67Single4PY02MeSATP4PY0-P2Y12-2MeSATP
16.67Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
16.67Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
16.67Single6A93Risperidone6A93-5-HT2A-Risperidone
16.67Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
16.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
16.67Single6ME9Ramelteon6ME9-MT2-Ramelteon
16.67Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
16.67Single6ZG4HTL00099366ZG4-M1-HTL0009936
16.67Single7DFPSpiperone7DFP-D2-Spiperone
16.67Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
16.67Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
16.67Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
16.67Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
16.67Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
16.67Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
16.67Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
16.67Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
16.67Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
16.67Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.67Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
16.67Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
16.67Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
16.67Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8JJ8Formoterol8JJ8-β2-Formoterol
16.67Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
16.67Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
16.67Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
16.67Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
16.67Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
16.67Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
16.28Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
16.22Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.22Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
16.22Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
16.22Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
16.22Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
16.13Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
16.13Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
16.13Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
16.13Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
16.13Single6H7LDobutamine6H7L-β1-Dobutamine
16.13Single6K1QIRL25006K1Q-ETB-IRL2500
16.13Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
16.13Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
16.13Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
16.13Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
16.13Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
16.13Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
16.13Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
16.13Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
16.13Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
16.00Single6HLLCP999946HLL-NK1-CP99994
16.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
16.00Single7UL2SR486927UL2-NTS1-SR48692-Na
16.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
16.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.00Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.00Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
16.00Single8K5BNiacin8K5B-HCA2-Niacin
16.00Consensusclass-t_onOrthosteric Ligandtaste2_on
16.00Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
16.00Consensusgo_proteinOrthosteric Ligandgo_chemokine
16.00Consensusgs_class-tOrthosteric Ligandgs_taste
16.00Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.00Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
16.00Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
16.00Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.79Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
15.79Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
15.62Single3NY9PubChem 9131033NY9-β2-PubChem 913103
15.62Single6PT3DPI-2876PT3-δ-DPI-287
15.62Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
15.62Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
15.62Single8X5YAstemizole8X5Y-H1-Astemizole
15.38Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
15.38Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
15.38Single5DHHSB-6121115DHH-NOP-SB-612111
15.38Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
15.38Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.38Single6AKXA4R6AKX-CCR5-A4R
15.38Single6B73PubChem 1319551386B73-κ-PubChem 131955138
15.38Single6LMLGlucagon6LML-Glucagon-Glucagon
15.38Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
15.38Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single6TODEMPA6TOD-OX1-EMPA-Na
15.38Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
15.38Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
15.38Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
15.38Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.38Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
15.38Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
15.38Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
15.38Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
15.38Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
15.38Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8IWESpermidine8IWE-TAAR9-Spermidine
15.38Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
15.38Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
15.38Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
15.38Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
15.38Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
15.38Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
15.38Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
15.38Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
15.38Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
15.22Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
15.15Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.15Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
15.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
14.81Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
14.81Single4MBSMaraviroc4MBS-CCR5-Maraviroc
14.81Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
14.81Single6AQFZM2413856AQF-A2A-ZM241385
14.81Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
14.81Single6PS4ICI 118-5516PS4-β2-ICI 118-551
14.81Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
14.81Single6TPGEMPA6TPG-OX2-EMPA
14.81Single6TPNHTL66416TPN-OX2-HTL6641
14.81Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
14.81Single6ZG9GSK10347026ZG9-M1-GSK1034702
14.81Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
14.81Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
14.81Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
14.81Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8GGKEpinephrine8GGK-β2-Epinephrine
14.81Single8GGLEpinephrine8GGL-β2-Epinephrine
14.81Single8GGMEpinephrine8GGM-β2-Epinephrine
14.81Single8GGPEpinephrine8GGP-β2-Epinephrine
14.81Single8GGQEpinephrine8GGQ-β2-Epinephrine
14.81Single8GGTEpinephrine8GGT-β2-Epinephrine
14.81Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
14.81Single8K2WAMG4878K2W-CXCR3-AMG487
14.81Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
14.81Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
14.81Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
14.71Single6HLOAprepitant6HLO-NK1-Aprepitant
14.71Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
14.29Single2Y04Salbutamol2Y04-β1-Salbutamol
14.29Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
14.29Single3NY8ICI 118-5513NY8-β2-ICI 118-551
14.29Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
14.29Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
14.29Single4EJ4Naltrindole4EJ4-δ-Naltrindole
14.29Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
14.29Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
14.29Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
14.29Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
14.29Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
14.29Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
14.29Single5UENDU1725UEN-A1-DU172
14.29Single6GPSMK08126GPS-CCR2-MK0812
14.29Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
14.29Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
14.29Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
14.29Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
14.29Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
14.29Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
14.29Single7BU7BI1671077BU7-β1-BI167107
14.29Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
14.29Single7F83PF-051904577F83-Ghrelin-PF-05190457
14.29Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
14.29Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
14.29Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
14.29Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
14.29Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
14.29Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
14.29Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
14.29Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
14.29Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.29Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.29Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GGJEpinephrine8GGJ-β2-Epinephrine
14.29Single8GGNEpinephrine8GGN-β2-Epinephrine
14.29Single8GGOEpinephrine8GGO-β2-Epinephrine
14.29Single8GGUEpinephrine8GGU-β2-Epinephrine
14.29Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
14.29Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
14.29Single8JJOAlprenolol8JJO-β2-Alprenolol
14.29Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
14.29Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
14.29Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
14.29Consensusadenosine_onOrthosteric Liganda1_on a2_on
14.29Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
14.29Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
14.29Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
14.29Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensusnucleotide_onOrthosteric Ligandadenosine_on
14.29Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
13.89Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
13.89Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
13.79Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
13.79Single2Y00Dobutamine2Y00-β1-Dobutamine
13.79Single2Y03Isoprenaline2Y03-β1-Isoprenaline
13.79Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
13.79Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
13.79Single5WIUNemonapride5WIU-D4-Nemonapride
13.79Single5WIVNemonapride5WIV-D4-Nemonapride-Na
13.79Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
13.79Single6E67BI1671076E67-β2-BI167107-Gs (fused)
13.79Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
13.79Single6GPXMK08126GPX-CCR2-MK0812
13.79Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
13.79Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
13.79Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
13.79Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
13.79Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
13.79Single7SINNPS-21437SIN-CaS-NPS-2143
13.79Single7SINNPS-21437SIN-CaS-NPS-2143
13.79Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
13.79Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
13.79Single7YXAONO-54306087YXA-S1P5-ONO-5430608
13.79Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
13.79Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
13.79Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
13.79Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
13.79Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
13.79Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
13.79Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
13.79Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
13.79Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
13.79Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
13.79Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
13.79Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
13.79Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
13.79Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
13.79Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
13.64Single5MZPCaffeine5MZP-A2A-Caffeine-Na
13.51Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.51Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
13.33Single2YDVNECA2YDV-A2A-NECA
13.33Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
13.33Single4UHRCGS216804UHR-A2A-CGS21680
13.33Single5G53NECA5G53-A2A-NECA-Gs
13.33Single5V57TC1145V57-SMO-TC114
13.33Single6E59L-7607356E59-NK1-L-760735
13.33Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
13.33Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
13.33Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
13.33Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
13.33Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
13.33Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
13.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
13.33Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
13.33Consensusa2_onOrthosteric Liganda2a_on a2b_on
13.33Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
13.33Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
13.33Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
13.33Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
13.33Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
13.33Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.16Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
13.04Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
13.04Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
13.04Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
13.04Single8PWNTheophylline8PWN-A2A-Theophylline
12.90Single5X33BIIL2605X33-BLT1-BIIL260
12.90Single6HLPNetupitant6HLP-NK1-Netupitant
12.90Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
12.90Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
12.90Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
12.90Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
12.90Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
12.90Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
12.90Consensusclass-b2_onOrthosteric Ligandadgrg_on
12.90Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
12.82Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
12.82Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
12.50Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
12.50Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
12.50Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
12.50Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
12.50Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
12.50Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
12.50Consensuscyslt_offOrthosteric Ligandcyslt2_off
12.50Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
12.12Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
12.12Single7SK9CCX6627SK9-ACKR3-CCX662
12.12Consensusclass-d_offOrthosteric Ligandste2_off
12.12Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Consensusgs_class-b2Orthosteric Ligandgs_adgr
12.00Single3UZAGTPL92363UZA-A2A-GTPL9236
12.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
12.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
12.00Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
12.00Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
12.00Single8GGREpinephrine8GGR-β2-Epinephrine
12.00Single8GGZEpinephrine8GGZ-β2-Epinephrine
12.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
12.00Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
12.00Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
12.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
12.00Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
12.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
12.00Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
11.76Single7QA8Peptide7QA8-STE2-Peptide
11.76Single7QA8Peptide7QA8-STE2-Peptide
11.76Consensusclass-d_offOrthosteric Ligandste2_off
11.54Single3PBLEticlopride3PBL-D3-Eticlopride
11.54Single4O9RCyclopamine4O9R-SMO-Cyclopamine
11.54Single5L7IVismodegib5L7I-SMO-Vismodegib
11.54Single6TP4ACT-4622066TP4-OX1-ACT-462206
11.54Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.54Single7SRQLSD7SRQ-5-HT2B-LSD
11.54Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.54Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
11.54Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
11.54Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
11.54Single8GGSEpinephrine8GGS-β2-Epinephrine
11.54Single8GGYEpinephrine8GGY-β2-Epinephrine
11.54Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
11.54Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
11.54Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
11.54Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
11.54Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.54Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.54Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.54Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
11.54Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
11.54Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.54Consensusgo_class-b2Orthosteric Ligandgo_adhesion
11.54Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
11.54Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.43Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
11.36Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
11.11Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
11.11Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single6AKYMaraviroc6AKY-CCR5-Maraviroc
11.11Single6KUXRS-799486KUX-α2a-RS-79948
11.11Single6ME2Ramelteon6ME2-MT1-Ramelteon
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
11.11Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
11.11Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
11.11Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
11.11Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
11.11Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
11.11Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
11.11Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
11.11Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
11.11Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
11.11Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
11.11Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
11.11Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
11.11Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
11.11Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
11.11Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.11Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.11Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.11Single8GGVEpinephrine8GGV-β2-Epinephrine
11.11Single8GGWEpinephrine8GGW-β2-Epinephrine
11.11Single8GGXEpinephrine8GGX-β2-Epinephrine
11.11Single8GH0Epinephrine8GH0-β2-Epinephrine
11.11Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
11.11Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
11.11Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.11Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.11Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.11Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.11Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.11Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.11Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.11Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
11.11Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.11Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
11.11Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
11.11Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
11.11Consensusclass-f_offOrthosteric Ligandsmo_off
11.11Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
10.81Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.81Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
10.81Consensusclass-d_onOrthosteric Ligandste2_on
10.81Consensusgi_class-dOrthosteric Ligandgi_ste
10.81Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.81Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
10.71Single2YDOAdenosine2YDO-A2A-Adenosine
10.71Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
10.71Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
10.71Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
10.71Single6TPKRetosiban6TPK-OT-Retosiban
10.71Single6VI4JDTic6VI4-κ-JDTic
10.71Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.71Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
10.71Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
10.71Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
10.71Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.71Single7VV6C48/807VV6-MRGPRX2-C48/80
10.71Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
10.71Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.71Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
10.71Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
10.71Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
10.71Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
10.71Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
10.71Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
10.71Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.71Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.71Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.71Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.71Single8GGIEpinephrine8GGI-β2-Epinephrine
10.71Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
10.71Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
10.71Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
10.71Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.71Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.71Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.71Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.71Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
10.71Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
10.71Consensus5ht5_onOrthosteric Ligand5ht5a_on
10.71Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
10.71Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
10.71Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
10.71Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
10.71Consensusgi_class-fOrthosteric Ligandgi_frizzled
10.71Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.71Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
10.71Consensusvasopressin-ot_offOrthosteric Ligandot_off
10.53Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
10.34Single2Y01Dobutamine2Y01-β1-Dobutamine
10.34Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
10.34Single5TGZAM65385TGZ-CB1-AM6538
10.34Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
10.34Single6H7MSalbutamol6H7M-β1-Salbutamol
10.34Single6IIVDaltroban6IIV-TP-Daltroban
10.34Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
10.34Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
10.34Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
10.34Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
10.34Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
10.34Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
10.34Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
10.34Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
10.34Single7WC7Lisuride7WC7-5-HT2A-Lisuride
10.34Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
10.34Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
10.34Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
10.34Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
10.34Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
10.34Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
10.34Single8X63Mepyramine8X63-H1-Mepyramine
10.34Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
10.34Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
10.34Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
10.34Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
10.34Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
10.34Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
10.34Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
10.34Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
10.34Consensustachykinin_offOrthosteric Ligandnk1_off
10.34Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
10.26Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
10.26Consensusclass-d_onOrthosteric Ligandste2_on
10.26Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
10.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
10.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
10.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
10.00Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
10.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
10.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
10.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
10.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
10.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
10.00Single7WC6LSD7WC6-5-HT2A-LSD
10.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
10.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
10.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
10.00Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
10.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
10.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
10.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
10.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
10.00Consensusep_offOrthosteric Ligandep4_off
10.00Consensusgi_class-dOrthosteric Ligandgi_ste
10.00Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.00Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
10.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
10.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
9.76Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
9.68Single6J21Aprepitant6J21-NK1-Aprepitant
9.68Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
9.68Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
9.68Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
9.68Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
9.68Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
9.68Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
9.68Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
9.68Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
9.68Consensushistamine_offOrthosteric Ligandh1_off
9.38Single4N4WSANT-14N4W-SMO-SANT-1
9.38Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
9.38Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
9.38Single6CM4Risperidone6CM4-D2-Risperidone
9.38Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
9.38Single6IIURamatroban6IIU-TP-Ramatroban
9.38Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
9.38Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.38Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
9.38Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.38Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
9.38Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
9.38Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
9.38Consensusgi_class-fOther Ligandgi_frizzled
9.38Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.38Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
9.09Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
9.09Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
9.09Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
9.09Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
9.09Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
9.09Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
9.09Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
9.09Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
8.82Single5EE7MK08935EE7-Glucagon-MK0893
8.82Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.70Single6W25Ca6W25-MC4-SHU9119-Ca
8.57Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
8.33Single7WC4Serotonin7WC4-5-HT2A-Serotonin
8.33Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
8.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
8.00Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
8.00Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
8.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
8.00Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
8.00Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
7.69Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
7.69Single6LI0GTPL98046LI0-GPR52-GTPL9804
7.69Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
7.69Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
7.69Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
7.69Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
7.41Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
7.41Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
7.41Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
7.41Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.41Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
7.41Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
7.41Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
7.41Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
7.41Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
7.41Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
7.14Single5U09Taranabant5U09-CB1-Taranabant
7.14Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
7.14Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
7.14Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
7.14Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
7.14Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.14Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
7.14Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
7.14Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
7.14Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
7.14Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
7.14Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
7.14Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
7.14Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
7.14Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
7.14Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Consensusalpha1_onOrthosteric Ligandalpha1a_on
7.14Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
7.14Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
7.14Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
7.14Consensusmglu_onOther Ligandmglu2_on mglu4_on
6.98Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
6.98Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
6.90Single3RZECidoxepin3RZE-H1-Cidoxepin
6.90Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
6.90Single6A94Zotepine6A94-5-HT2A-Zotepine
6.90Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
6.90Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
6.90Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
6.90Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
6.90Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
6.90Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
6.90Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
6.90Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
6.90Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
6.90Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
6.90Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
6.90Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.90Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
6.90Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
6.90Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
6.90Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
6.90Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.90Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
6.90Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
6.90Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
6.90Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.90Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
6.90Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
6.90Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
6.90Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.90Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
6.90Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
6.90Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
6.90Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
6.90Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
6.82Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
6.67Single4DAJTiotropium4DAJ-M3-Tiotropium
6.67Single4MQSIperoxo4MQS-M2-Iperoxo
6.67Single4U14Tiotropium4U14-M3-Tiotropium
6.67Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
6.67Single5DSGTiotropium5DSG-M4-Tiotropium
6.67Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
6.67Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
6.67Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
6.67Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
6.67Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
6.67Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
6.67Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
6.67Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
6.67Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
6.67Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
6.67Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
6.67Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single8X64Desloratadine8X64-H1-Desloratadine
6.67Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
6.67Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
6.67Consensushistamine_onOrthosteric Ligandh1_on h4_on
6.67Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
6.67Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
6.67Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.67Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
6.67Consensustar_onOrthosteric Ligandta1_on
6.52Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
6.52Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
6.45Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
6.45Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
6.45Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
6.45Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
6.45Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.45Single8EA0Iperoxo8EA0-M3-Iperoxo
6.45Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
6.45Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
6.45Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
6.45Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.45Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
6.45Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
6.45Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
6.25Single4U15Tiotropium4U15-M3-Tiotropium
6.25Single5V54Methiothepin5V54-5-HT1B-Methiothepin
6.25Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
6.25Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
6.25Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
6.25Single6OL9Tiotropium6OL9-M5-Tiotropium
6.25Single7EPENAM5637EPE-mGlu-NAM563
6.25Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
6.25Single7P2L4YI7P2L-mGlu5-4YI
6.25Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
6.25Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
6.25Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
6.25Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
6.25Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
6.25Consensus5ht1_offOrthosteric Ligand5ht1b_off
6.25Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
6.25Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
6.25Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
6.25Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
6.06Single5CXVTiotropium5CXV-M1-Tiotropium
6.06Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
6.06Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
6.06Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
6.00Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
5.88Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
5.88Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
5.88Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
5.88Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
5.88Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.88Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.66Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
5.56Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
5.13Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
4.76Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.76Single6D35Cholesterol6D35-SMO-Cholesterol
4.76Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.76Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.76Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
4.76Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
4.76Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.76Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.76Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.76Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
4.76Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
4.76Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
4.76Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.76Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.76Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.76Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.76Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
4.76Single7DTTCa7DTT-CaS-Ca-Ca
4.76Single7DTTCa7DTT-CaS-Ca-Ca
4.76Single7DTUTryptophan7DTU-CaS-Tryptophan
4.76Single7DTUTryptophan7DTU-CaS-Tryptophan
4.76Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.76Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.76Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.76Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.76Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.76Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.76Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
4.76Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
4.76Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
4.76Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.76Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.76Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.76Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.76Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.76Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.76Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single7FIIhCG7FII-LH-hCG-6fuf
4.76Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
4.76Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
4.76Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.76Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.76Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.76Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.76Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.76Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.76Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
4.76Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
4.76Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.76Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.76Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.76Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.76Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
4.76Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.76Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.76Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.76Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.76Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.76Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.76Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
4.76Single7XW7K1-707XW7-TSH-K1-70
4.76Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.76Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.76Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.76Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.76Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.76Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.76Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.76Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.76Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.76Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.76Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.76Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.76Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
4.76Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.76Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.76Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.76Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.76Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
4.76Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
4.76Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.76Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.76Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.76Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.76Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.76Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.76Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
4.76Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
4.76Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.76Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.76Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.76Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.76Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.76Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.76Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.76Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.76Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.76Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.76Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.76Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.76Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
4.76Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
4.76Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
4.76Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
4.76Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.76Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.76Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
4.76Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
4.76Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
4.76Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
4.76Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.76Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.76Consensusgphr_onOrthosteric Ligandlh_on tsh_on
4.76Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
4.76Consensusgs_proteinOrthosteric Ligandgs_gphr
4.76Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
4.76Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
4.76Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
4.76Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.76Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.76Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
4.76Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
4.76Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.76Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.76Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
4.76Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
4.76Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
4.76Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
4.76Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
4.76Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
4.76Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
4.76Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
4.76Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.55Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.55Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.55Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.55Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.55Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.55Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.55Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.55Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.55Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.55Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.55Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.55Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.55Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.35Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.35Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.35Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
4.35Single8HS2Fab0468HS2-GPR20-Fab046
4.17Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.17Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
4.17Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
4.17Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.17Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.17Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
4.00Single5L7DCholesterol5L7D-SMO-Cholesterol
4.00Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
4.00Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.00Consensusclass-c_onOther Ligandgabab_on mglu_on
3.85Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
3.85Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
3.85Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
3.85Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
3.85Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
3.85Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.85Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
3.85Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Consensussensory_onOrthosteric Ligandopsin_on
3.70Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
3.70Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
3.70Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
3.70Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
3.70Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
3.70Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
3.70Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
3.70Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
3.70Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
3.70Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
3.70Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
3.70Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
3.57Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
3.57Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
3.57Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
3.57Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
3.57Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
3.57Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
3.57Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
3.57Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
3.57Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
3.57Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
3.57Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
3.57Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
3.57Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
3.57Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
3.57Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
3.57Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
3.57Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
3.45Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
3.45Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
3.45Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
3.45Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
3.45Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
3.45Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
3.45Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
3.45Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
3.45Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
3.45Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
3.45Single8G94CD698G94-S1P1-CD69-Gi1/&β;1/&γ;2
3.45Consensusgt_class-aOrthosteric Ligandgt_opsin
3.45Consensusgt_opsinOrthosteric Ligandgt_sensory
3.45Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
3.45Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
3.45Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
3.33Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
3.33Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
3.33Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
3.33Single7VODCariprazine7VOD-5-HT2A-Cariprazine
3.33Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
3.33Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
3.33Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
3.33Single8IYXYL-3658IYX-GPR34-YL-365
3.33Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.33Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
3.33Consensussensory_offOrthosteric Ligandopsin_off
3.23Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
3.23Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.23Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.23Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
3.12Single5CGCHTL142425CGC-mGlu5-HTL14242
3.12Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.12Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
3.12Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
3.03Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.03Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.03Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.03Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
3.03Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
2.94Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
2.86Single5CGDHTL142425CGD-mGlu5-HTL14242
2.86Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.86Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.78Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.78Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.63Single7SHEPI; PE7SHE-GPR158-PI; PE
2.13Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3

Consensus Members
Id Members
7F9Y 7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7F9Z 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
Net Summary
Imin 3.1
Number of Linked Nodes 848
Number of Links 1007
Number of Hubs 150
Number of Links mediated by Hubs 587
Number of Communities 30
Number of Nodes involved in Communities 238
Number of Links involved in Communities 333
Path Summary
Number Of Nodes in MetaPath 83
Number Of Links MetaPath 82
Number of Shortest Paths 2957220
Length Of Smallest Path 3
Average Path Length 38.1473
Length of Longest Path 63
Minimum Path Strength 0.685
Average Path Strength 7.10429
Maximum Path Strength 22.11
Minimum Path Correlation 0.7
Average Path Correlation 0.985636
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.22222
Average % Of Corr. Nodes 31.3958
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.2363
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gs_peptidegs_cck
gs_motilin
gs_neuromedin
gs_orexin
gs_sst
gs_tachykinin
gs_trh
gs_vasopressin-ot
gs_bombesin
gs_bradykinin
gs_compl-peptide
gs_endothelin
gs_galanin
gs_ghrelin
gs_melanocortin



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