Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.37 2.99929403
2G.HN.52 1.70071403
3G.S1.02 3.40943506
4G.S1.06 5.88857468
5G.H1.01 4.39393469
6G.S2.03 6.49571419
7G.S3.03 5.7319608
8G.S3.04 8.87536417
9G.S3.06 8.71543517
10G.H2.03 5.29643419
11G.H2.05 6.78536418
12G.H2.06 5.57929619
13G.H2.07 6.73457519
14G.h2s4.01 7.56943519
15G.H3.01 5.19286409
16G.H3.08 5.77357408
17G.H3.09 4.242257109
18G.H3.13 10.83324106
19G.H3.17 8.52714615
20G.S5.05 5.07738669
21G.S5.07 4.57071409
22G.s5hg.01 5.17571409
23G.HG.03 3.32571406
24G.hgh4.01 6.62214406
25G.hgh4.05 8.04829506
26G.hgh4.11 3.55786405
27G.hgh4.20 4.46457503
28G.H4.03 3.44214404
29G.H4.10 9.80643407
30G.H4.12 5.10643404
31G.H4.15 7.41179408
32G.h4s6.12 5.08257502
33G.S6.02 7.873145178
34G.S6.05 5.541434185
35G.s6h5.01 4.3425469
36G.s6h5.05 3.85464469
37G.H5.03 5.36857469
38G.H5.06 5.89321464
39G.H5.08 5.74171588
40G.H5.13 5.60393408
41G.H5.15 3.86857408
42G.H5.17 4.90536405
43G.H5.23 5.93929634
44G.H5.24 5.47314536
45b.1x4 2.72964408
46b.1x11 2.9625408
47b.h2x1 4.2125405
48b.lhb1x3 3.16036402
49b.lhb1x6 3.854294113
50b.l1x3 8.11619659
51b.l1x6 9.15171519
52b.b2x1 6.18257518
53b.b2x5 8.45964407
54b.l3x1 7.2825419
55b.l3x2 6.068575169
56b.b4x2 5.95607408
57b.b4x6 11.9877559
58b.l4x2 8.120364214
59b.b5x2 7.35143457
60b.b5x3 6.12024659
61b.b5x7 5.90929407
62b.l5x1 4.651715138
63b.l5x5 9.19686519
64b.b6x1 4.47943519
65b.b6x5 3.983816206
66b.l6x5 6.24144
67b.b7x1 6.04254144
68b.b8x4 5.326575136
69b.l8x3 2.9775403
70b.b9x3 3.68857406
71b.l9x3 7.05143519
72b.l9x6 5.31405618
73b.b10x5 4.60357609
74b.l10x1 3.62107403
75b.l11x2 7.16714519
76b.b12x6 8.57595618
77b.b13x7 6.52886577
78b.l13x3 7.51214679
79b.l13x6 7.18107419
80b.l13x7 4.32571479
81b.l15x1 4.75214417
82b.l15x2 6.33714479
83b.b16x4 9.76571476
84b.b16x5 3.82036405
85b.b16x6 8.62119678
86b.b17x5 6.99107447
87b.b17x7 8.36679448
88b.l17x3 9.35095649
89b.l17x6 7.62429419
90b.b18x3 4.58457548
91b.b18x5 4.30643405
92b.l18x1 7.385246
93b.b19x2 6.50238646
94b.b19x4 6.42071448
95b.l19x2 4.69179409
96b.b20x4 7.69524648
97b.b20x6 6.4802746
98b.b20x7 3.84314509
99b.l20x2 6.245715159
100b.b21x1 8.96179447
101b.b21x5 6.13357404
102b.b21x7 5.19429605
103b.b22x5 5.323715247
104b.l22x5 5.778576119
105b.b23x6 7.667435127
106b.l23x1 5.88619616
107b.b24x4 6.717864126
108b.b24x6 5.902864128
109b.l24x3 4.47464405
110b.l25x3 7.03943599
111b.l25x6 11.4617518
112b.l28x1 8.42612719
113b.l28x2 6.62143499
114b.b28x3 3.735407
115b.b28x4 6.5425496
116b.b28x6 8.90257599
117g.h1x10 2.90686509
118g.l1x4 3.53829508
119g.ctx3 5.92514509
120g.ctx6 2.81357406
1211x36 2.92829506
1221x42 4.74179428
1231x50 4.46893409
1242x39 5.35286437
1252x40 1.75036408
1262x50 5.48643429
1272x51 4.00536407
1282x57 5.03571406
129E1 3.43016924
1303x28 4.86429406
1313x33 4.13357428
1323x34 4.27343507
1333x35 4.02029507
1343x46 4.10714409
1353x49 5.68964439
1363x50 4.93514539
137I2x51 5.37286485
138I2x53 7.87321438
1394x60 5.71071429
140E2 10.33492725
141E2x51 6.41464428
142E2x52 5.15738626
1436x29 3.44214405
1446x30 5.46929408
1456x32 4.33024637
1466x33 4.67571438
1476x37 3.4625438
1486x54 2.83314505
149E3 12.3367621
1507x39 6.83229528
1517x45 4.96714409
1527x46 4.54428
1537x51 5.60214406
1547x53 5.84036409
1558x55 3.66714434
156Lig 6.418571520
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1G.HN.36 b.b5x2 45.18437.90429NoYes547
2G.HN.40 b.b5x2 92.572510.0229NoYes577
3G.HN.40 b.b5x3 92.76745.22286NoYes579
4b.b4x4 b.b5x3 47.04954.15429NoYes589
5b.b4x4 b.l1x3 47.146210.7957NoYes589
6b.b3x6 b.l1x3 95.5979.56143NoYes099
7b.b3x6 b.l3x2 95.6678.20286NoYes099
8b.b4x6 b.b5x3 47.276610.9371YesYes599
9b.b4x6 b.l1x3 47.63217.40571YesYes599
10G.hns1.01 b.l3x2 98.14113.61286NoYes1649
11G.S1.03 G.hns1.01 99.377314.2586NoNo094
12G.S1.03 G.S3.06 99.43993.97286NoYes097
13G.S3.06 b.l5x5 10018.04YesYes179
14G.h2s4.01 b.l5x5 66.847613.8886YesYes199
15G.H2.07 G.h2s4.01 66.99473.57857YesYes199
16G.H2.04 G.H2.07 60.98698NoYes099
17G.H2.04 G.H3.08 60.931810.4557NoYes098
18G.H3.08 G.S4.04 60.78096.55143YesNo089
19G.H3.09 G.S4.04 46.80743.21286YesNo099
20G.H3.09 G.H3.13 47.12244.00714YesYes1096
21G.H3.13 G.h4s6.13 47.143225.2386YesNo067
22G.h4s6.12 G.h4s6.13 47.07043.06286YesNo027
23G.H5.21 G.h4s6.12 46.56836.24571NoYes042
246x29 G.H5.21 46.49674.23571YesNo054
256x29 G.H5.24 46.29286.35857YesYes056
266x33 G.H5.24 42.32784.18571YesYes386
276x33 G.H5.23 38.07333.39YesYes384
28G.H5.10 G.S6.02 15.283712.4771NoYes078
296x30 G.H5.17 16.75264.12429YesYes085
306x30 G.H5.20 17.31143.32429YesNo088
316x33 G.H5.20 17.90146.33429YesNo088
32G.HG.03 G.s4h3.02 10.21284.07286YesNo069
33G.HG.07 G.s4h3.02 10.36264.59NoNo099
34G.HG.07 G.s4h3.04 10.6686.65286NoNo098
35G.HG.15 G.s4h3.04 10.92127.77NoNo078
36G.H4.08 G.hgh4.11 14.63443.77286NoYes035
37G.H4.08 G.H4.12 14.88197.93571NoYes034
38G.H4.12 G.S6.05 15.414.27857YesYes045
39G.S5.06 G.S6.05 17.64354.34714NoYes085
40G.S5.04 G.S5.06 17.77634.74571NoNo098
41G.S4.04 G.S5.04 16.77623.30571NoNo099
42G.H2.07 b.l9x6 54.3213.58286YesYes198
43b.l11x1 b.l9x6 21.20127.03429NoYes198
44b.b11x6 b.l11x1 21.07613.71NoNo199
45b.l5x5 b.l7x2 30.06486.01857YesNo199
46b.b6x1 b.l7x2 30.05833.03143YesNo199
47b.b6x1 b.l9x6 32.78495.13YesYes198
48G.H2.06 b.l9x6 68.07133.58YesYes198
49G.H2.06 b.l17x6 33.7376.52YesYes199
50G.H2.06 b.b18x1 33.73764YesNo099
512x39 G.H5.23 27.314710.0214YesYes374
52b.l17x6 b.l19x1 33.7154.56143YesNo099
53b.l17x5 b.l19x1 66.99343.57286NoNo069
54b.l17x5 b.l19x2 66.67552.52286NoYes069
55b.l17x4 b.l19x2 20.46376.86857NoYes039
56b.b20x4 b.l17x4 20.13743.15714YesNo083
57b.b20x4 b.b20x6 38.29915.64714YesYes486
58b.b17x7 b.b20x6 38.585712.0957YesYes486
59b.b17x7 b.b21x1 26.67285.63YesYes487
60b.1x19 b.b21x1 21.72227.14714NoYes067
61b.1x15 b.1x19 16.74553.21857NoNo076
62b.1x12 b.1x15 14.75392.06571NoNo067
63b.1x12 b.1x16 13.75791.76857NoNo064
64b.1x13 b.1x16 12.76185.51NoNo014
65b.1x13 b.1x9 10.76913.37571NoNo014
66b.b18x1 b.l19x1 33.59625.58NoNo099
67b.b20x2 b.l19x2 20.79494.75143NoYes069
68b.b20x2 b.b20x4 20.14243.51NoYes068
69b.b19x6 b.l19x2 25.09954.62429NoYes099
70b.b19x6 b.l17x3 24.773312.7529NoYes099
71b.b20x6 b.l17x3 19.15754.20429YesYes469
72b.b11x6 b.l9x3 19.049212.9514NoYes199
73b.b11x4 b.l9x3 13.00524.69714NoYes199
74b.b10x3 b.b11x4 12.95854.10429NoNo089
75b.b10x3 b.b6x2 12.59164.82857NoNo088
76b.b10x2 b.b6x2 12.4083.13857NoNo068
77G.HN.36 b.b4x7 44.95125.59429NoNo548
78b.b4x7 b.l2x5 89.42413.6143NoNo085
79b.l2x5 b.l4x2 83.672818.2257NoYes054
80b.l4x1 b.l4x2 75.56593.81429NoYes054
81b.b2x5 b.l4x1 75.08364.94YesNo075
82b.b2x5 b.l27x1 72.18711.4357YesNo077
83b.l27x1 b.l27x3 71.21097.02143NoNo1977
84b.l27x3 b.l27x5 70.736910.2971NoNo075
85b.l27x5 g.ctx4 70.25326.47NoNo057
86g.ctx3 g.ctx4 68.80164.14YesNo097
87g.ctx3 g.ctx6 43.20685.81714YesYes096
88b.l22x5 g.ctx6 41.24183.46857YesYes096
89b.l22x5 b.l24x2 33.85047.98286YesNo1196
90b.h2x5 b.l24x2 33.36134.42NoNo056
91b.h2x1 b.h2x5 32.37392.31571YesNo055
92b.b5x2 b.l4x3 45.18438.77286YesNo576
93b.b4x7 b.l4x3 44.95128.87857NoNo586
94b.b21x5 b.h2x1 19.96016.66286YesYes045
95g.ctx3 g.ctx5 23.21613.68429YesNo099
96b.lhb1x11 g.ctx5 20.73735.05NoNo049
97b.b25x7 b.lhb1x11 20.24043.83429NoNo074
98b.b25x7 b.b28x6 18.245117.0843NoYes079
99b.b19x2 b.b20x6 16.90659.34143YesYes466
100b.b17x5 b.b17x7 10.94146.86286YesYes478
101b.b21x5 b.b21x7 16.480610.4357YesYes045
102E2 Lig 12.7819.97714YesYes250
1037x46 Lig 23.36046.26143YesYes280
1042x50 7x46 22.88935.12714YesYes298
1052x46 2x50 24.52945.81714NoYes099
1062x46 3x46 24.77493.23143NoYes099
1072x39 3x46 26.9043.55429YesYes079
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
1x387x3911.45570NoYes4821
1x39Lig8.431430NoYes7010
1x427x394.057142YesYes8811
1x427x423.724292YesNo8911
1x427x436.772862YesNo8512
1x42Lig4.412862YesYes8010
2x503x397.538572YesNo9922
2x533x356.868570NoYes8721
2x54Lig11.680NoYes8010
2x563x313.701430NoNo5412
2x573x283.107140YesYes6612
2x57Lig8.671430YesYes6010
2x603x289.548570NoYes6612
2x64E1x504.552862NoNo7522
2x65E24.458572NoYes8521
E1E23.568572YesYes4521
E1E1x504.695712YesNo4522
E1x50E26.438572NoYes5521
E1E14.088572YesYes4422
3x26E24.602862NoYes4521
3x283x323.731430YesNo6821
3x29E28.451430NoYes7521
3x30E23.202862NoYes5521
3x32E2x513.725710NoYes8812
3x32Lig7.024290NoYes8010
4x594x603.517142NoYes6922
4x60E28.912YesYes9521
4x60E2x523.264292YesYes9622
E2E274.03712YesYes5511
5x34E210.77862NoYes0521
E2E2x524.095712YesYes5612
E2E2x519.337142YesYes5812
E2Lig9.977142YesYes5010
7x34E27.412862NoYes7521
7x35E25.052862NoYes6511
7x38E25.744292NoYes7511
E2x51E2x528.535712YesYes8622
6x58E23.168572NoYes6521
E2E314.04572YesYes5112
5x35E24.041430NoYes3521
E3E321.10862YesYes1122
7x357x3911.10572NoYes6811
7x35Lig5.114292NoYes6010
7x38Lig4.081432NoYes7010
7x39Lig5.707142YesYes8010
7x42Lig11.63572NoYes9010
7x457x463.382860YesYes9821
7x46Lig6.261432YesYes8010
2x507x465.127142YesYes9821
3x397x463.388572NoYes9821
6x517x383.191430NoNo8721
1x432x576.607140NoYes7621
2x56Lig3.857140NoYes5010
2x60Lig4.420NoYes6010
2x64E23.922862NoYes7521
3x343x356.735710YesYes7721
4x59E23.181432NoYes6521
7x34E35.381432NoYes7122
3x35Lig2.667140YesYes7010
5x36E22.470NoYes5521
E2E2x502.448572YesNo5912
3x36Lig2.337140NoYes7010
3x22E22.182NoYes1521
2x523x351.915710NoYes5721
2x5513x351.914290NoYes0721
7x367x391.835710NoYes4821
2x572x581.757140YesNo6712
4x62E21.507140NoYes4521
7x31E21.290NoYes4521
1x392x611.191430NoNo7812
4x63E20.6814290NoYes7521

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
93.33Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
87.50Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
81.25Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
81.25Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
81.25Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
80.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
75.00Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
72.22Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
70.59Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
70.59Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
68.75Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
68.75Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
68.42Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
66.67Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
66.67Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
66.67Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
66.67Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
66.67Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
64.71Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
63.16Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
61.11Single6IIURamatroban6IIU-TP-Ramatroban
58.82Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
58.82Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
57.89Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
52.94Single6IIVDaltroban6IIV-TP-Daltroban
52.94Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
52.94Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
52.94Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
50.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
50.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
50.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
50.00Consensusep_offOrthosteric Ligandep4_off
47.37Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
47.06Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
42.11Single7YXAONO-54306087YXA-S1P5-ONO-5430608
41.18Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
40.00Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
38.89Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
38.89Single8K5CAcipimox8K5C-HCA2-Acipimox
38.89Consensushca_onOrthosteric Ligandhca2_on hca3_on
38.89Consensushcar_onOrthosteric Ligandhca_on
36.84Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
36.84Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
36.84Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
36.84Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
35.29Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
35.29Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
35.29Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
35.29Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
35.29Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
35.29Single8K5BNiacin8K5B-HCA2-Niacin
35.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
35.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
35.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
35.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
34.78Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
34.78Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
33.33Single5U09Taranabant5U09-CB1-Taranabant
33.33Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
33.33Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
33.33Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
33.33Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
31.82Single4N4WSANT-14N4W-SMO-SANT-1
31.82Single5X33BIIL2605X33-BLT1-BIIL260
31.58Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
31.58Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
31.58Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
31.58Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
31.58Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
31.58Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
31.58Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
31.58Single8K2WAMG4878K2W-CXCR3-AMG487
31.58Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
31.58Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
31.25Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
30.43Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
30.00Single5TGZAM65385TGZ-CB1-AM6538
30.00Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
30.00Consensusgi_hcarOrthosteric Ligandgi_hca
30.00Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
30.00Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
29.41Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
29.17Single5EE7MK08935EE7-Glucagon-MK0893
29.17Single7SK9CCX6627SK9-ACKR3-CCX662
28.57Single5CGCHTL142425CGC-mGlu5-HTL14242
28.57Single6GPXMK08126GPX-CCR2-MK0812
28.57Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
28.57Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
28.57Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
28.57Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Single7QA8Peptide7QA8-STE2-Peptide
28.00Single7QA8Peptide7QA8-STE2-Peptide
28.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
28.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
28.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
28.00Consensusclass-d_offOrthosteric Ligandste2_off
28.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
27.78Single5L7IVismodegib5L7I-SMO-Vismodegib
27.59Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
27.59Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
27.27Single4DJHJDTic4DJH-κ-JDTic
27.27Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
27.27Single7TUYGSK682753A7TUY-GPR183-GSK682753A
27.27Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
27.27Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
27.27Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
26.92Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
26.92Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
26.92Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
26.92Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
26.92Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
26.67Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single5ZKQABT-4915ZKQ-PAF-ABT-491
26.32Single6AKXA4R6AKX-CCR5-A4R
26.32Single6AKYMaraviroc6AKY-CCR5-Maraviroc
26.32Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
26.32Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
26.32Single8IHKAcifran8IHK-HCA3-Acifran
26.32Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
26.32Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
26.09Single6A93Risperidone6A93-5-HT2A-Risperidone
26.09Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
26.09Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
26.09Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
26.09Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
26.09Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
26.09Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
26.09Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
26.09Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
26.09Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
26.09Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
26.09Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
26.09Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
26.09Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
25.81Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.00Single2YDOAdenosine2YDO-A2A-Adenosine
25.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
25.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
25.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
25.00Single5CGDHTL142425CGD-mGlu5-HTL14242
25.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
25.00Single6H7LDobutamine6H7L-β1-Dobutamine
25.00Single6TPGEMPA6TPG-OX2-EMPA
25.00Single6VI4JDTic6VI4-κ-JDTic
25.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
25.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
25.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
25.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
25.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
25.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
25.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
25.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
25.00Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
25.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
25.00Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
25.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
25.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
25.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
25.00Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
25.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
25.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.00Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
25.00Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
25.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
25.00Consensuss1p_offOrthosteric Ligands1p1_off
24.14Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
24.14Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
24.14Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
24.14Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
24.00Single5ZTYAM102575ZTY-CB2-AM10257
24.00Single6PT3DPI-2876PT3-δ-DPI-287
24.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
24.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
24.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
24.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
24.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
24.00Single8X5YAstemizole8X5Y-H1-Astemizole
24.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
24.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
24.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
24.00Consensusclass-d_offOrthosteric Ligandste2_off
24.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
24.00Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
24.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
23.81Single2Y01Dobutamine2Y01-β1-Dobutamine
23.81Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
23.81Single4YAYZD-71554YAY-AT1-ZD-7155
23.81Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
23.81Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
23.81Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
23.81Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
23.81Single6GPSMK08126GPS-CCR2-MK0812
23.81Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
23.81Single6TOTLemborexant6TOT-OX1-Lemborexant
23.81Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
23.81Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
23.81Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
23.81Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
23.81Single7UL4Alvimopan7UL4-μ-Alvimopan
23.81Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
23.81Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
23.81Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
23.81Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
23.81Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
23.81Single8K5DGSK2560738K5D-HCA2-GSK256073
23.81Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
23.81Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
23.81Consensusadenosine_onOrthosteric Liganda1_on a2_on
23.81Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
23.81Consensusblt_onOrthosteric Ligandblt1_on
23.81Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
23.81Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
23.81Consensushcar_offOrthosteric Ligandsuccinate_off
23.81Consensusleuko_onOrthosteric Ligandblt_on
23.81Consensusnucleotide_onOrthosteric Ligandadenosine_on
23.81Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
23.81Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
23.81Consensustar_onOrthosteric Ligandta1_on
23.53Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Consensusclass-d_onOrthosteric Ligandste2_on
23.33Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
23.08Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
23.08Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
23.08Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
23.08Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
23.08Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
23.08Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
22.86Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
22.73Single2Y00Dobutamine2Y00-β1-Dobutamine
22.73Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
22.73Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
22.73Single5C1MBU725C1M-μ-BU72
22.73Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
22.73Single5WQCEMPA5WQC-OX2-EMPA
22.73Single6D26Fevipiprant6D26-DP2-Fevipiprant
22.73Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
22.73Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
22.73Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
22.73Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
22.73Single6TP6Filorexant6TP6-OX1-Filorexant
22.73Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
22.73Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
22.73Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
22.73Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
22.73Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
22.73Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
22.73Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
22.73Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
22.73Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
22.73Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
22.73Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
22.73Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
22.73Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
22.73Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
22.73Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
22.73Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
22.73Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
22.73Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
22.73Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.58Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
22.58Consensusgi_class-dOrthosteric Ligandgi_ste
22.58Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.22Single3OE6IT1t3OE6-CXCR4-IT1t
22.22Single3QAKUK-4320973QAK-A2A-UK-432097
22.22Single6LI0GTPL98046LI0-GPR52-GTPL9804
22.22Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
22.22Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
22.22Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
22.22Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
22.22Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
22.22Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
21.88Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
21.88Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
21.88Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
21.88Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
21.74Single2YDVNECA2YDV-A2A-NECA
21.74Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
21.74Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
21.74Single4UHRCGS216804UHR-A2A-CGS21680
21.74Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
21.74Single5G53NECA5G53-A2A-NECA-Gs
21.74Single5V56TC1145V56-SMO-TC114
21.74Single5V57TC1145V57-SMO-TC114
21.74Single5XR8AM8415XR8-CB1-AM841
21.74Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
21.74Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
21.74Single6TQ7SB-3348676TQ7-OX1-SB-334867
21.74Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
21.74Single7P2L4YI7P2L-mGlu5-4YI
21.74Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
21.74Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
21.74Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
21.74Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
21.74Single8E0GBU728E0G-μ-BU72
21.74Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
21.74Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
21.74Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
21.74Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
21.74Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
21.74Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
21.74Consensusa2_onOrthosteric Liganda2a_on a2b_on
21.74Consensuscck_onOrthosteric Ligandccka_on cckb_on
21.74Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
21.74Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
21.74Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
21.74Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
21.43Single5WF5UK-4320975WF5-A2A-UK-432097
21.43Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
21.43Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
21.43Consensusangiotensin_onOrthosteric Ligandat1_on
21.43Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
21.43Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
21.43Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
21.43Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
21.21Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
21.21Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
21.21Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
21.05Single3OE9IT1t3OE9-CXCR4-IT1t
21.05Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
21.05Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
21.05Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
21.05Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
21.05Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
21.05Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
21.05Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Consensusclass-t_onOrthosteric Ligandtaste2_on
21.05Consensusgs_class-tOrthosteric Ligandgs_taste
21.05Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
21.05Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
20.83Single4LDEBI1671074LDE-β2-BI167107
20.83Single6CM4Risperidone6CM4-D2-Risperidone
20.83Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
20.83Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
20.83Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.83Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.83Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
20.83Single6ZG4HTL00099366ZG4-M1-HTL0009936
20.83Single7DFPSpiperone7DFP-D2-Spiperone
20.83Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
20.83Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
20.83Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
20.83Single7K15MKD0467K15-BLT1-MKD046-Na
20.83Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
20.83Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single7YITNalfurafine7YIT-κ-Nalfurafine
20.83Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
20.83Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
20.83Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
20.83Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
20.83Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single8JJ8Formoterol8JJ8-β2-Formoterol
20.83Single8WU1KCA8WU1-CB1-KCA-Arrestin1
20.83Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
20.83Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
20.83Consensusblt_offOrthosteric Ligandblt1_off
20.83Consensusclass-b2_onOrthosteric Ligandadgrg_on
20.83Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
20.83Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
20.83Consensusdp_offOrthosteric Liganddp2_off
20.83Consensusgi_class-fOther Ligandgi_frizzled
20.83Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
20.83Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
20.83Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.83Consensusgs_steroidOrthosteric Ligandgs_bileacid
20.83Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
20.69Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
20.69Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
20.69Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
20.69Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.69Single7C61Ergotamine7C61-5-HT1B-Ergotamine
20.69Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
20.69Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
20.69Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
20.69Consensusclass-d_onOrthosteric Ligandste2_on
20.69Consensusgi_class-dOrthosteric Ligandgi_ste
20.69Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.69Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
20.69Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.59Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
20.59Consensusglp_onOrthosteric Ligandglp1_on glp2_on
20.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
20.00Single3ODUIT1t3ODU-CXCR4-IT1t
20.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
20.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
20.00Single5DHHSB-6121115DHH-NOP-SB-612111
20.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
20.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
20.00Single5WS3EMPA5WS3-OX2-EMPA
20.00Single6B73PubChem 1319551386B73-κ-PubChem 131955138
20.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
20.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
20.00Single6IBLArformoterol6IBL-β1-Arformoterol
20.00Single6K1QIRL25006K1Q-ETB-IRL2500
20.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
20.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
20.00Single6TODEMPA6TOD-OX1-EMPA-Na
20.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
20.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
20.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
20.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
20.00Single7EZCUKA7EZC-A2A-UKA
20.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
20.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
20.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
20.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
20.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
20.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
20.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
20.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
20.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
20.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
20.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
20.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
20.00Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GGVEpinephrine8GGV-β2-Epinephrine
20.00Single8GGWEpinephrine8GGW-β2-Epinephrine
20.00Single8GGXEpinephrine8GGX-β2-Epinephrine
20.00Single8GH0Epinephrine8GH0-β2-Epinephrine
20.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
20.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
20.00Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
20.00Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8IWESpermidine8IWE-TAAR9-Spermidine
20.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
20.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
20.00Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
20.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
20.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
20.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
20.00Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
20.00Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
20.00Consensusendothelin_offOrthosteric Ligandetb_off
20.00Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
20.00Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
20.00Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
20.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.00Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
20.00Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
20.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
20.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
20.00Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
20.00Consensussteroid_onOrthosteric Ligandbileacid_on
20.00Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
20.00Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
19.51Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
19.35Single4XT3Fractalkine4XT3-US28-Fractalkine
19.35Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
19.35Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
19.35Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
19.35Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
19.35Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
19.35Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
19.35Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
19.35Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
19.23Single3NY9PubChem 9131033NY9-β2-PubChem 913103
19.23Single4UG2CGS216804UG2-A2A-CGS21680
19.23Single5WF6UK-4320975WF6-A2A-UK-432097
19.23Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
19.23Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
19.23Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
19.23Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
19.23Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
19.23Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Consensusgs_class-b2Orthosteric Ligandgs_adgr
19.23Consensuslpl_offOrthosteric Ligands1p_off lpa_off
19.23Consensuslpl_onOrthosteric Ligands1p_on lpa_on
19.23Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
19.23Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.05Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
19.05Single6DS0Ly2660976DS0-5-HT2B-Ly266097
19.05Single6FFIMMPEP6FFI-mGlu5-MMPEP
19.05Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
19.05Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
19.05Single6PS4ICI 118-5516PS4-β2-ICI 118-551
19.05Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
19.05Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
19.05Single6TP3Nemorexant6TP3-OX1-Nemorexant
19.05Single6V9SGTPL114036V9S-OX1-GTPL11403
19.05Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
19.05Single7AROLUF58337ARO-A2A-LUF5833-Na
19.05Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
19.05Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
19.05Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
19.05Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
19.05Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
19.05Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
19.05Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
19.05Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.05Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
19.05Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
19.05Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
19.05Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
19.05Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
19.05Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GGIEpinephrine8GGI-β2-Epinephrine
19.05Single8GGQEpinephrine8GGQ-β2-Epinephrine
19.05Single8GGTEpinephrine8GGT-β2-Epinephrine
19.05Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
19.05Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
19.05Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
19.05Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
19.05Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
19.05Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
19.05Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
19.05Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
19.05Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
18.75Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
18.75Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
18.75Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
18.75Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
18.75Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
18.75Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
18.52Single4IARErgotamine4IAR-5-HT1B-Ergotamine
18.52Single4XT1Fractalkine4XT1-US28-Fractalkine
18.52Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.52Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
18.52Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
18.52Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
18.52Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
18.52Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
18.52Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
18.52Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
18.52Consensussst_onOrthosteric Ligandsst2_on sst4_on
18.18Single2Y04Salbutamol2Y04-β1-Salbutamol
18.18Single3NY8ICI 118-5513NY8-β2-ICI 118-551
18.18Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
18.18Single4EJ4Naltrindole4EJ4-δ-Naltrindole
18.18Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
18.18Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
18.18Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
18.18Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
18.18Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
18.18Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
18.18Single5UENDU1725UEN-A1-DU172
18.18Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
18.18Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
18.18Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
18.18Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
18.18Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
18.18Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
18.18Single6FFHFenobam6FFH-mGlu5-Fenobam
18.18Single6H7MSalbutamol6H7M-β1-Salbutamol
18.18Single6IGLIRL16206IGL-ETB-IRL1620
18.18Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
18.18Single6LMLGlucagon6LML-Glucagon-Glucagon
18.18Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
18.18Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
18.18Single6PS1Timolol6PS1-β2-Timolol
18.18Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
18.18Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
18.18Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
18.18Single7BU7BI1671077BU7-β1-BI167107
18.18Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
18.18Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
18.18Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
18.18Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
18.18Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
18.18Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
18.18Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
18.18Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
18.18Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
18.18Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
18.18Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
18.18Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
18.18Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
18.18Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
18.18Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
18.18Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
18.18Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8GGJEpinephrine8GGJ-β2-Epinephrine
18.18Single8GGNEpinephrine8GGN-β2-Epinephrine
18.18Single8GGOEpinephrine8GGO-β2-Epinephrine
18.18Single8GGUEpinephrine8GGU-β2-Epinephrine
18.18Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
18.18Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
18.18Single8JJOAlprenolol8JJO-β2-Alprenolol
18.18Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
18.18Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
18.18Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
18.18Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
18.18Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
18.18Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
18.18Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
18.18Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
18.18Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
18.18Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
18.18Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
18.18Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
18.18Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
18.18Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
18.18Consensushistamine_onOrthosteric Ligandh1_on h4_on
18.18Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
18.18Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
17.86Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
17.86Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
17.86Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
17.86Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
17.86Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
17.86Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
17.86Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
17.86Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
17.86Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
17.86Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
17.86Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
17.65Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
17.65Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
17.65Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
17.65Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.39Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
17.39Single2Y03Isoprenaline2Y03-β1-Isoprenaline
17.39Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
17.39Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
17.39Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
17.39Single5WIUNemonapride5WIU-D4-Nemonapride
17.39Single5WIVNemonapride5WIV-D4-Nemonapride-Na
17.39Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
17.39Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
17.39Single6E67BI1671076E67-β2-BI167107-Gs (fused)
17.39Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
17.39Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
17.39Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
17.39Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
17.39Single6PS6Timolol6PS6-β2-Timolol
17.39Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
17.39Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
17.39Single7C4SS1P7C4S-S1P3-S1P
17.39Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
17.39Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
17.39Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
17.39Single7WC6LSD7WC6-5-HT2A-LSD
17.39Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
17.39Single7XKAEpinephrine7XKA-β2-Epinephrine
17.39Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
17.39Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
17.39Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.39Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
17.39Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
17.39Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
17.39Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
17.39Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
17.39Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
17.39Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
17.39Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
17.39Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
17.39Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
17.39Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
17.39Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
17.39Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
17.39Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
17.39Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
17.39Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
17.39Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
17.39Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
17.24Single6PT2KGCHM076PT2-δ-KGCHM07
17.24Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.24Single6W25SHU91196W25-MC4-SHU9119-Ca
17.24Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
17.24Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
17.24Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
17.24Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
17.24Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
17.24Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
17.24Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
17.24Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
17.14Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
17.14Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
17.14Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
17.14Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
16.67Single3P0GBI1671073P0G-β2-BI167107
16.67Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
16.67Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
16.67Single4RWADIPP-NH24RWA-δ-DIPP-NH2
16.67Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
16.67Single4U15Tiotropium4U15-M3-Tiotropium
16.67Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
16.67Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
16.67Single5X93K-87945X93-ETB-K-8794
16.67Single5XRAAM115425XRA-CB1-AM11542
16.67Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
16.67Single6H7JIsoprenaline6H7J-β1-Isoprenaline
16.67Single6J21Aprepitant6J21-NK1-Aprepitant
16.67Single6JODAngiotensin II6JOD-AT2-Angiotensin II
16.67Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
16.67Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.67Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.67Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
16.67Single6OL9Tiotropium6OL9-M5-Tiotropium
16.67Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
16.67Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
16.67Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
16.67Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
16.67Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
16.67Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
16.67Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
16.67Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
16.67Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
16.67Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
16.67Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
16.67Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
16.67Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
16.67Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
16.67Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
16.67Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
16.67Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
16.67Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
16.67Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
16.67Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
16.67Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
16.67Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
16.67Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
16.67Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
16.67Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
16.67Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
16.67Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
16.67Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
16.67Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusadenosine_offOrthosteric Liganda1_off a2_off
16.67Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
16.67Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
16.67Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
16.67Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
16.67Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
16.67Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
16.67Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
16.67Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
16.67Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
16.67Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
16.67Consensushistamine_offOrthosteric Ligandh1_off
16.67Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
16.67Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
16.67Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
16.67Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.67Consensusrelaxin_onOrthosteric Ligandrxfp4_on
16.67Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
16.67Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
16.67Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
16.22Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
16.22Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
16.22Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
16.22Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
16.13Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.13Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
16.13Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
16.13Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
16.13Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
16.13Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
16.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
16.00Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
16.00Single4AMIBucindolol4AMI-β1-Bucindolol
16.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
16.00Single5CXVTiotropium5CXV-M1-Tiotropium
16.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
16.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
16.00Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
16.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
16.00Single6MXTSalmeterol6MXT-β2-Salmeterol
16.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
16.00Single6OS2TRV0266OS2-AT1-TRV026
16.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
16.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
16.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
16.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
16.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
16.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
16.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
16.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
16.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
16.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
16.00Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
16.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
16.00Single8JJLOlodaterol8JJL-β2-Olodaterol
16.00Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
16.00Single8JWZAB9288JWZ-A2A-AB928-Na
16.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
16.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
16.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
16.00Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
16.00Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
16.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
16.00Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
16.00Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
16.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.79Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
15.79Single3OE8IT1t3OE8-CXCR4-IT1t
15.79Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
15.79Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
15.79Single8GGREpinephrine8GGR-β2-Epinephrine
15.79Single8GGZEpinephrine8GGZ-β2-Epinephrine
15.79Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
15.79Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
15.79Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
15.79Consensuspth_onOrthosteric Ligandpth1_on pth2_on
15.62Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
15.62Single6FJ3PTH6FJ3-PTH1-PTH
15.62Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.62Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.62Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
15.62Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
15.62Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Single7SK3CXCL127SK3-ACKR3-CXCL12
15.62Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
15.62Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
15.62Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
15.62Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
15.62Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
15.38Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
15.38Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
15.38Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
15.38Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
15.38Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
15.38Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
15.38Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
15.38Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
15.38Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
15.38Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
15.38Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
15.38Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.38Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
15.38Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
15.38Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.38Consensusorexin_onOrthosteric Ligandox2_on
15.15Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
15.15Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
15.15Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.15Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
15.15Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
15.15Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
15.15Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
15.15Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
15.15Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
15.15Consensusendothelin_onOrthosteric Ligandetb_on eta_on
15.15Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
15.15Consensusgo_class-b1Orthosteric Ligandgo_crf
15.15Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
15.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
15.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
15.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
15.00Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
15.00Single7SRQLSD7SRQ-5-HT2B-LSD
15.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
15.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
15.00Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
15.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
15.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
15.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
15.00Single8GGSEpinephrine8GGS-β2-Epinephrine
15.00Single8GGYEpinephrine8GGY-β2-Epinephrine
15.00Single8GH1Epinephrine8GH1-β2-Epinephrine
15.00Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
15.00Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
15.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
15.00Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
15.00Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
14.81Single7XN9L-054,5227XN9-SST2-L-054,522
14.81Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
14.81Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
14.81Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
14.81Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
14.81Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
14.81Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
14.71Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
14.71Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
14.71Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
14.71Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
14.71Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
14.71Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
14.71Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.71Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
14.71Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
14.71Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
14.71Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
14.63Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
14.29Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
14.29Single3PWHZM2413853PWH-A2A-ZM241385
14.29Single5GLHEndothelin-15GLH-ETB-Endothelin-1
14.29Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
14.29Single6IGKEndothelin-36IGK-ETB-Endothelin-3
14.29Single6KUXRS-799486KUX-α2a-RS-79948
14.29Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
14.29Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
14.29Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
14.29Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
14.29Single7F8XNN90567F8X-CCKA-NN9056
14.29Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
14.29Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
14.29Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
14.29Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
14.29Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
14.29Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
14.29Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
14.29Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
14.29Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
14.29Single7XRRLemborexant7XRR-OX2-Lemborexant
14.29Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
14.29Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GNGIstradefylline8GNG-A2A-Istradefylline
14.29Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
14.29Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
14.29Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
14.29Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
14.29Consensusclass-f_offOrthosteric Ligandsmo_off
14.29Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
14.29Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
14.29Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
14.29Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusgt_class-aOrthosteric Ligandgt_opsin
14.29Consensusgt_opsinOrthosteric Ligandgt_sensory
14.29Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
14.29Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
13.89Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
13.89Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
13.79Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
13.79Single6HLOAprepitant6HLO-NK1-Aprepitant
13.79Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
13.79Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
13.79Single7SK5CXCL127SK5-ACKR3-CXCL12
13.79Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
13.79Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
13.64Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
13.64Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
13.64Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
13.64Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
13.64Single5IU4ZM2413855IU4-A2A-ZM241385-Na
13.64Single5IUBQ274563445IUB-A2A-Q27456344-Na
13.64Single5K2CZM2413855K2C-A2A-ZM241385-Na
13.64Single5NM4ZM2413855NM4-A2A-ZM241385-Na
13.64Single6AQFZM2413856AQF-A2A-ZM241385
13.64Single6IQLL7458706IQL-D4-L745870
13.64Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
13.64Single6TPKRetosiban6TPK-OT-Retosiban
13.64Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
13.64Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
13.64Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
13.64Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
13.64Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
13.64Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
13.64Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
13.64Single7T32ZM2413857T32-A2A-ZM241385
13.64Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
13.64Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
13.64Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
13.64Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
13.64Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.64Single8GGKEpinephrine8GGK-β2-Epinephrine
13.64Single8GGMEpinephrine8GGM-β2-Epinephrine
13.64Single8GGPEpinephrine8GGP-β2-Epinephrine
13.64Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
13.64Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
13.64Consensus5ht5_onOrthosteric Ligand5ht5a_on
13.64Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
13.64Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
13.64Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
13.64Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
13.64Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
13.64Consensussensory_offOrthosteric Ligandopsin_off
13.64Consensusvasopressin-ot_offOrthosteric Ligandot_off
13.51Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
13.51Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.33Single3OE0CVX153OE0-CXCR4-CVX15
13.33Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
13.33Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
13.33Single7XNACYN1548067XNA-SST2-CYN154806
13.33Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
13.33Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
13.16Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
13.16Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
13.16Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
13.16Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
13.16Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
13.04Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
13.04Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
13.04Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
13.04Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
13.04Single4DAJTiotropium4DAJ-M3-Tiotropium
13.04Single4EIYZM2413854EIY-A2A-ZM241385-Na
13.04Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
13.04Single4MQSIperoxo4MQS-M2-Iperoxo
13.04Single4U14Tiotropium4U14-M3-Tiotropium
13.04Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
13.04Single5DSGTiotropium5DSG-M4-Tiotropium
13.04Single5IU8Q274563475IU8-A2A-Q27456347-Na
13.04Single5OLGZM2413855OLG-A2A-ZM241385-Na
13.04Single6D27CAY104716D27-DP2-CAY10471
13.04Single6DRXLisuride6DRX-5-HT2B-Lisuride
13.04Single6LPJZM2413856LPJ-A2A-ZM241385-Na
13.04Single6LPKZM2413856LPK-A2A-ZM241385-Na
13.04Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
13.04Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
13.04Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
13.04Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
13.04Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
13.04Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
13.04Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.04Single7PYRPSB-21157PYR-A2A-PSB-2115
13.04Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
13.04Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
13.04Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
13.04Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
13.04Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
13.04Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
13.04Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
13.04Single7WC7Lisuride7WC7-5-HT2A-Lisuride
13.04Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
13.04Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
13.04Single8CU6LJ-45178CU6-A2A-LJ-4517
13.04Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
13.04Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
13.04Single8X63Mepyramine8X63-H1-Mepyramine
13.04Single8X64Desloratadine8X64-H1-Desloratadine
13.04Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
13.04Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
13.04Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
13.04Consensusa2_offOrthosteric Liganda2a_off
13.04Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
13.04Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
13.04Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
13.04Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
12.90Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
12.90Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
12.90Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
12.90Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.90Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
12.90Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
12.90Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.90Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.82Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
12.82Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
12.50Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
12.50Single5IUAQ274563485IUA-A2A-Q27456348-Na
12.50Single5N2SPSB365N2S-A1-PSB36
12.50Single5NM2ZM2413855NM2-A2A-ZM241385-Na
12.50Single5TVNLSD5TVN-5-HT2B-LSD
12.50Single5XPRBosentan5XPR-ETB-Bosentan
12.50Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
12.50Single6LPLZM2413856LPL-A2A-ZM241385-Na
12.50Single6LUQHaloperidol6LUQ-D2-Haloperidol
12.50Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
12.50Single6S0QZM2413856S0Q-A2A-ZM241385
12.50Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
12.50Single6WQAZM2413856WQA-A2A-ZM241385-Na
12.50Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
12.50Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
12.50Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
12.50Single7RM5ZM2413857RM5-A2A-ZM241385-Na
12.50Single7SINNPS-21437SIN-CaS-NPS-2143
12.50Single7SINNPS-21437SIN-CaS-NPS-2143
12.50Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
12.50Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
12.50Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
12.50Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
12.50Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
12.50Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
12.50Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
12.50Single8EA0Iperoxo8EA0-M3-Iperoxo
12.50Single8FYNZM2413858FYN-A2A-ZM241385-Na
12.50Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
12.50Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
12.50Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
12.50Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
12.50Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
12.50Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.12Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
12.12Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
12.00Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
12.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
12.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
12.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
12.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
12.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
12.00Single6OS1TRV0266OS1-AT1-TRV026
12.00Single6WGTLSD6WGT-5-HT2A-LSD
12.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
12.00Single7EPENAM5637EPE-mGlu-NAM563
12.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
12.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
12.00Single7PX4PSB-21137PX4-A2A-PSB-2113
12.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
12.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
12.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
12.00Single7W41PD1762527W41-BB2-PD176252
12.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
12.00Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
12.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
12.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
12.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
12.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
12.00Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
12.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
12.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
12.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
12.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
12.00Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
12.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
12.00Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
12.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
12.00Consensusbombesin_offOrthosteric Ligandbb2_off
12.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
12.00Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
12.00Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
12.00Consensuslpa_offOrthosteric Ligandlpa1_off
12.00Consensuslpa_onOrthosteric Ligandlpa1_on
12.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
12.00Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
12.00Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
11.76Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
11.76Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
11.76Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
11.76Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
11.76Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
11.76Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
11.63Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
11.54Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
11.54Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
11.54Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
11.54Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
11.54Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
11.54Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensuschemokine_offOrthosteric Ligandcxcr_off
11.54Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
11.54Consensuscxcr_offOrthosteric Ligandcxcr4_off
11.54Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
11.43Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
11.43Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
11.43Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
11.43Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
11.43Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
11.43Single8IY6Endothelin-18IY6-ETB-Endothelin-1
11.11Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
11.11Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
11.11Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
11.11Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
11.11Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
11.11Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
11.11Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
11.11Single7UM4AS26747237UM4-5-HT5A-AS2674723
11.11Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
11.11Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
11.11Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
11.11Single8PWNTheophylline8PWN-A2A-Theophylline
11.11Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
11.11Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
10.81Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
10.81Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
10.71Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
10.71Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
10.71Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.71Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
10.71Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
10.53Single6TQ9SB-4081246TQ9-OX1-SB-408124
10.53Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.53Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
10.53Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
10.53Single8A2OTheophylline8A2O-A2A-Theophylline-Na
10.53Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Consensussensory_onOrthosteric Ligandopsin_on
10.34Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
10.34Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
10.34Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
10.34Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
10.34Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
10.34Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
10.34Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
10.26Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
10.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
10.00Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
10.00Single3UZAGTPL92363UZA-A2A-GTPL9236
10.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
10.00Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
10.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
10.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
10.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
10.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
10.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
10.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
10.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
10.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
10.00Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
10.00Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
10.00Consensussst_offOrthosteric Ligandsst2_off
9.68Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
9.68Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.68Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
9.68Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
9.68Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
9.52Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
9.52Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
9.52Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
9.52Single3PBLEticlopride3PBL-D3-Eticlopride
9.52Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
9.52Single4O9RCyclopamine4O9R-SMO-Cyclopamine
9.52Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
9.52Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
9.52Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
9.52Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
9.52Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
9.52Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
9.52Single7FEEZCZ0117FEE-CB1-PubMed 104895-ZCZ011
9.52Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
9.52Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
9.52Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
9.52Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
9.52Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
9.52Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
9.52Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
9.52Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
9.52Consensusgo_class-b2Orthosteric Ligandgo_adhesion
9.52Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
9.52Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.38Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
9.38Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
9.09Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
9.09Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
9.09Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
9.09Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
9.09Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
9.09Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
9.09Single4QINSAG1.54QIN-SMO-SAG1.5
9.09Single5K2DZM2413855K2D-A2A-ZM241385
9.09Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
9.09Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
9.09Single6JZHZM2413856JZH-A2A-ZM241385-Na
9.09Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.09Single6ME2Ramelteon6ME2-MT1-Ramelteon
9.09Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
9.09Single6PS7ZM2413856PS7-A2A-ZM241385-Na
9.09Single7BR3Elagolix7BR3-GnRH1-Elagolix
9.09Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
9.09Single7F8ULintitript7F8U-CCKA-Lintitript
9.09Single7F8YDevazepide7F8Y-CCKA-Devazepide
9.09Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
9.09Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
9.09Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.09Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
9.09Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
9.09Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
9.09Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
9.09Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
9.09Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
9.09Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
9.09Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
9.09Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
9.09Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
9.09Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
9.09Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
9.09Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.09Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
9.09Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
9.09Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
9.09Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
9.09Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
9.09Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
8.82Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
8.82Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
8.82Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
8.70Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
8.70Single3REYPubChem 56973REY-A2A-PubChem 5697
8.70Single3RZECidoxepin3RZE-H1-Cidoxepin
8.70Single5IU7Q274563465IU7-A2A-Q27456346-Na
8.70Single5JTBZM2413855JTB-A2A-ZM241385
8.70Single5K2BZM2413855K2B-A2A-ZM241385-Na
8.70Single5NLXZM2413855NLX-A2A-ZM241385-Na
8.70Single6A94Zotepine6A94-5-HT2A-Zotepine
8.70Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
8.70Single6MH8ZM2413856MH8-A2A-ZM241385
8.70Single6TPNHTL66416TPN-OX2-HTL6641
8.70Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.70Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
8.70Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
8.70Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single7VODCariprazine7VOD-5-HT2A-Cariprazine
8.70Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
8.70Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
8.70Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
8.70Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
8.70Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
8.70Single8GGLEpinephrine8GGL-β2-Epinephrine
8.70Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
8.70Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
8.70Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.70Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
8.70Consensusgi_class-fOrthosteric Ligandgi_frizzled
8.70Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.70Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
8.70Consensusgnrh_offOrthosteric Ligandgnrh1_off
8.70Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
8.33Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
8.33Single2Y02Carmoterol2Y02-β1-Carmoterol
8.33Single3EMLZM2413853EML-A2A-ZM241385
8.33Single5K2AZM2413855K2A-A2A-ZM241385-Na
8.33Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
8.33Single5VRAZM2413855VRA-A2A-ZM241385-Na
8.33Single6S0LZM2413856S0L-A2A-ZM241385
8.33Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
8.33Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
8.33Single7F83PF-051904577F83-Ghrelin-PF-05190457
8.33Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
8.33Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
8.33Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
8.33Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
8.33Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
8.33Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
8.33Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
8.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
8.33Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
8.33Consensuscck_offOrthosteric Ligandccka_off
8.33Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
8.33Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
8.33Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
8.33Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
8.33Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
8.33Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.33Consensustachykinin_offOrthosteric Ligandnk1_off
8.11Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
8.11Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
8.11Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
8.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
8.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
8.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
8.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
8.00Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
8.00Single8QOTNanobody E8QOT-μ-Nanobody E
8.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
8.00Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.89Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
7.69Single6E59L-7607356E59-NK1-L-760735
7.69Single6J20Aprepitant6J20-NK1-Aprepitant
7.69Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.69Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
7.69Single7F1TMIP-1a7F1T-CCR5-MIP-1a
7.69Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
7.69Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
7.69Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
7.69Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.69Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
7.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.69Consensuschemerin_onOrthosteric Ligandcml1_on
7.69Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
7.69Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
7.69Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
7.69Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
7.69Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
7.41Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
7.41Single6HLPNetupitant6HLP-NK1-Netupitant
7.41Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
7.41Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
7.41Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
7.14Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
7.14Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
7.14Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
7.14Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
7.14Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.14Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
6.90Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.90Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.90Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.90Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
6.90Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
6.90Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.90Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.82Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
6.82Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
6.67Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
6.67Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
6.67Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
6.67Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
6.67Single8W8SAA-148W8S-GPR101-AA-14
6.67Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
6.67Consensusclass-c_offOther Ligandgabab_off mglu_off
6.45Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.45Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.45Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
6.38Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
6.25Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
6.25Single8W8RAA-148W8R-GPR101-AA-14-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.71Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
5.56Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
5.56Single5MZPCaffeine5MZP-A2A-Caffeine-Na
5.56Single6W25Ca6W25-MC4-SHU9119-Ca
5.56Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.56Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
5.41Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
5.41Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
5.26Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
5.26Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
5.26Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.26Single7WC4Serotonin7WC4-5-HT2A-Serotonin
5.26Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
5.26Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.26Consensusclass-c_onOther Ligandgabab_on mglu_on
5.00Single3RFMCaffeine3RFM-A2A-Caffeine
5.00Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.00Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
5.00Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
5.00Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
4.88Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
4.88Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
4.76Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
4.76Single4XNWMRS25004XNW-P2Y1-MRS2500
4.76Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
4.76Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
4.76Single6ME5Agomelatine6ME5-MT1-Agomelatine
4.76Single6ME9Ramelteon6ME9-MT2-Ramelteon
4.76Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
4.76Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
4.76Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
4.65Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.55Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
4.55Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
4.55Single6HLLCP999946HLL-NK1-CP99994
4.55Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
4.55Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
4.55Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
4.55Single6TP4ACT-4622066TP4-OX1-ACT-462206
4.55Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
4.55Single7LD3PubChem 252636037LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
4.55Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
4.55Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
4.55Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.55Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusa1_on_alloOther Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
4.55Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.55Consensusgo_proteinOrthosteric Ligandgo_chemokine
4.55Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
4.55Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
4.35Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
4.35Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
4.35Single4BWBNeurotensin4BWB-NTS1-Neurotensin
4.35Single4XNVBPTU4XNV-P2Y1-BPTU
4.35Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
4.35Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
4.35Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
4.35Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
4.35Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.35Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
4.35Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.35Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
4.35Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
4.35Single7WV9ZCZ0117WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.35Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
4.35Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.35Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
4.35Consensuscb1_on_alloOther Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.35Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.35Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
4.35Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.17Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
4.17Single5UVIZM2413855UVI-A2A-ZM241385
4.17Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
4.17Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
4.17Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
4.17Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
4.17Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
4.17Single7VV6C48/807VV6-MRGPRX2-C48/80
4.17Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
4.17Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
4.17Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
4.17Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
4.17Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
4.17Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single5T04Neurotensin5T04-NTS1-Neurotensin
4.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
4.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
4.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
4.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
4.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
4.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
4.00Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.00Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.00Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
4.00Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
3.85Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
3.85Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
3.85Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
3.85Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
3.85Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.85Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
3.85Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
3.85Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
3.85Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
3.70Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
3.70Single4BV0Neurotensin4BV0-NTS1-Neurotensin
3.70Single5TZR-5TZR-FFA1 (GPR40)-MK8666
3.70Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
3.70Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
3.70Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
3.70Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
3.70Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
3.70Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.70Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
3.70Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
3.57Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
3.57Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
3.57Single4PY02MeSATP4PY0-P2Y12-2MeSATP
3.57Single4XEENeurotensin4XEE-NTS1-Neurotensin
3.57Single4XESNeurotensin4XES-NTS1-Neurotensin
3.57Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
3.57Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
3.57Single6YVRNTS8-136YVR-NTS1-NTS8-13
3.57Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
3.57Single7SHEPI; PE7SHE-GPR158-PI; PE
3.57Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
3.57Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
3.57Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.57Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
3.57Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
3.57Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
3.57Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
3.57Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
3.57Consensusnts_onOrthosteric Ligandnts1_on
3.57Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
3.45Single4BUONeurotensin4BUO-NTS1-Neurotensin
3.45Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
3.45Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
3.45Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
3.45Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
3.45Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.45Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
3.45Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.45Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
3.45Consensuscyslt_offOrthosteric Ligandcyslt2_off
3.45Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.45Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
3.33Single6KNMJN241-96KNM-Apelin-JN241-9
3.33Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
3.33Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
3.23Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
3.23Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
3.23Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.12Single7SHEPI; PE7SHE-GPR158-PI; PE
3.12Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.12Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.03Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on

Consensus Members
Id Members
8IUK 8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8IUM 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7CX2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2
7CX3 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
7D7M 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
7CX4 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
8IUL 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
Net Summary
Imin 2.87571
Number of Linked Nodes 899
Number of Links 1055
Number of Hubs 156
Number of Links mediated by Hubs 619
Number of Communities 24
Number of Nodes involved in Communities 202
Number of Links involved in Communities 287
Path Summary
Number Of Nodes in MetaPath 108
Number Of Links MetaPath 107
Number of Shortest Paths 2349507
Length Of Smallest Path 3
Average Path Length 35.4722
Length of Longest Path 64
Minimum Path Strength 0.652143
Average Path Strength 6.76153
Maximum Path Strength 17.5614
Minimum Path Correlation 0.702857
Average Path Correlation 0.981743
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.78571
Average % Of Corr. Nodes 39.964
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.4309
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gs_lipidgs_ffa
gs_prostanoid



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