Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1b.1x4 3.13408
2b.1x11 2.73754198
3b.lhb1x6 2.3825403
4b.b1x3 6.34487
5b.l1x3 6.075717119
6b.b2x5 6.494507
7b.l3x2 4.7565119
8b.b4x6 6.985717119
9b.b4x7 7.114228
10b.l4x2 7.3375484
11b.b5x3 4.8725409
12b.b5x5 4.2154165
13b.l5x5 4.76857719
14b.b6x5 3.754506
15b.b7x1 3.105644
16b.l7x2 4.225419
17b.l7x4 4.6325409
18b.b8x4 3.4075406
19b.l8x1 2.8454165
20b.l8x5 3.34443
21b.l9x6 3.7721018
22b.b10x4 4.73254206
23b.b10x5 3.31286749
24b.l10x1 2.735403
25b.l11x1 4.5175419
26b.b12x6 5.92648
27b.b13x7 6.064597
28b.l13x3 5.382599
29b.l13x6 5.5625419
30b.b15x1 5699
31b.b15x3 3.5525499
32b.l15x2 4.6575409
33b.b16x5 3.7575405
34b.b16x6 7.29698
35b.b17x7 6.1425438
36b.l17x3 4.55739
37b.b18x3 3.2425438
38b.l18x1 4.751676136
39b.l18x2 5.30754137
40b.b19x2 5.19536
41b.b19x4 4.296538
42b.l19x2 5.35539
43b.b20x2 3.5436
44b.b20x4 6.99833638
45b.b20x6 6.58536
46b.b21x3 6.935436
47b.b21x5 5.2675464
48b.b21x7 4.98667665
49b.b22x5 4.81254137
50b.l22x5 5.2125129
51b.b23x6 5.57833667
52b.l23x1 5.7675406
53b.b24x4 5.87566
54b.b24x6 6.265468
55b.b24x7 5.8045129
56b.l24x3 6.754125
57b.b25x3 6.8465
58b.b25x6 3.2875463
59b.l25x3 10.0225479
60b.l25x5 3.5925477
61b.l28x1 10.214579
62b.l28x2 5.33579
63b.b28x4 7.0625476
64b.b28x6 5.98579
65g.h2x11 8.07754136
66g.ctx3 6.456509
67g.ctx15 5.025489
68g.ctx16 3.73333688
69NT 20.556523
701x35 5.242505
711x39 4.6225408
72I1x51 3.2925407
732x42 3.54167607
742x51 2.54407
752x53 4.4985236
76E1x50 5.09125828
77E1x52 4.6875427
783x24 3.3675425
793x50 5.03409
80I2x55 3.9575405
81I2 5.19167606
824x53 2.65754247
83E2 15.78291424
845x40 2.2525405
855x47 5.914558
865x57 2.6925407
875x58 4.72833609
88I3 5.48254144
896x48 5.165459
90E3 7.53424
917x42 4.48254237
927x45 6.53559
937x49 5.8725459
947x53 4.15559
957x55 2.4554176
968x50 5.5985178
97Lig 67.2631020
98G.HN.43 2.43408
99G.S1.02 3.831676104
100G.S2.08 4.2885105
101G.S3.01 3.55254104
102G.S3.06 7.052516
103G.H2.06 3.94519
104G.H2.07 4.77419
105G.H2.09 6.625408
106G.h2s4.01 4.34519
107G.S4.04 4.208577279
108G.H3.09 7.0825409
109G.H3.18 4.035269
110G.S5.04 3.538509
111G.S5.05 3.427147189
112G.s5hg.01 3.33254289
113G.HG.04 6.065408
114G.hgh4.01 3.9254154
115G.hgh4.02 4.3085158
116G.H4.15 5.4375408
117G.S6.02 5.821676148
118G.s6h5.01 4.64254189
119G.H5.05 3.8954105
120G.H5.14 3.9054146
121G.H5.25 3.31754256
122G.H5.26 4.8075405
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b17x5 b.b17x7 10.94588.2NoYes078
2b.b19x4 b.l17x3 14.80595.48YesYes389
3b.l17x3 b.l19x2 19.44012.52YesYes399
4b.l17x5 b.l19x2 24.71825.89NoYes069
5b.l17x5 b.l19x1 24.93732.94NoNo069
6b.l19x1 b.l21x8 25.39111.68NoNo094
7b.l21x8 b.l23x1 25.61961.68NoYes046
8b.l23x1 b.l25x6 41.07910.72YesNo068
9b.l25x6 b.l28x1 40.95713.99NoYes789
10b.b26x1 b.l28x1 36.94734.94NoYes099
11b.b26x1 b.b26x2 36.71995.16NoNo097
12b.b26x2 b.b2x3 36.73793.24NoNo076
13b.b2x3 b.b2x5 36.29822.33NoYes067
14G.H2.09 b.l28x1 81.63052.12YesYes089
15b.b10x4 b.b2x4 11.019911.28YesNo066
16b.b2x4 b.b6x5 11.26232.18NoYes066
17b.b2x5 b.l4x1 20.72064.94YesNo075
18b.l4x1 b.l4x2 20.49952.54NoYes054
19b.b3x1 b.b6x5 16.42262.34NoYes056
20b.b3x1 b.b4x7 16.65744.07NoYes058
21b.b4x7 b.l2x5 17.078913.1YesNo085
22G.H2.09 b.b6x1 78.3143.94YesNo089
23b.b6x1 b.l9x6 76.37482.39NoYes198
24b.l11x1 b.l9x6 13.81435.79YesYes198
25b.b11x6 b.l11x1 13.58793.71NoYes099
26b.b11x6 b.l9x3 12.574313.95NoNo099
27b.b12x6 b.l9x3 10.48512.12YesNo489
28G.H2.07 b.l9x6 84.74711.93YesYes198
29b.l21x7 b.l23x1 14.7437.78NoYes056
30b.l21x7 b.l23x2 14.48076.22NoNo058
31b.b23x6 b.l23x2 12.63593.45YesNo078
32E2 E2x52 27.69664.17YesNo245
334x65 E2x52 28.56536.52NoNo055
344x61 4x65 44.80344.39NoNo045
353x33 4x61 45.22575.03NoNo054
363x33 4x57 45.64773.42NoNo056
373x34 4x57 49.84987.74NoNo056
383x34 4x53 51.10393.1NoYes057
393x38 4x53 51.91883.44NoYes2477
403x38 4x49 52.77161.71NoNo076
413x42 4x49 53.60342.98NoNo076
422x45 3x42 26.59132.75NoNo097
432x45 4x46 26.77454.72NoNo097
442x42 4x46 32.3452.69YesNo077
452x42 3x49 91.74413.45YesNo078
463x49 I2 91.87758.34NoYes086
473x53 I2 92.80194.15NoYes086
483x53 G.H5.19 93.19311.56NoNo088
49G.H5.19 I2x50 93.32291.56NoNo088
50G.H5.15 I2x50 93.71011.62NoNo088
51G.H5.11 G.H5.15 93.83861.54NoNo088
52G.H5.11 G.S1.02 93.96671.6NoYes084
53G.S1.02 G.S1.04 94.38542.98YesNo047
54G.S1.04 G.S4.01 96.5021.58NoNo078
55G.S4.01 G.S5.03 95.68221.62NoNo088
56G.S5.03 G.S5.05 99.22553.77NoYes089
57G.H1.04 G.S5.05 49.96813.77NoYes079
58G.H1.04 G.S5.07 49.98998.5NoNo079
59G.S5.07 G.s1h1.06 1001.7NoNo099
60G.s1h1.06 G.s5hg.01 99.92481.74NoYes099
61G.S4.07 G.s5hg.01 99.6972.77NoYes089
62G.S4.07 G.s1h1.05 99.388810.31NoNo089
63G.s1h1.02 G.s1h1.05 99.31091.71NoNo079
64G.H3.05 G.s1h1.02 99.23271.71NoNo097
65G.H3.05 G.S4.04 93.09732.64NoYes2799
66G.H3.08 G.S4.04 86.25173.58NoYes099
67G.H2.04 G.H3.08 86.13898.34NoNo099
68G.H2.04 G.H2.07 86.03172NoYes099
692x46 3x42 27.85722.83NoNo097
702x46 3x46 36.12452.92NoNo099
712x42 3x46 59.60943.63YesNo079
72G.S5.05 G.s6h5.01 49.96755.19YesYes1899
73G.S5.07 G.s6h5.01 50.08625.85NoYes099
743x32 7x42 12.41097.22NoYes2377
752x60 3x32 20.385713.5NoNo067
762x60 E1x50 21.26813.75NoYes068
77E1x50 E2 14.68994.64YesYes284
78E1x50 E2x50 14.523310.45YesNo289
793x29 E2x50 15.3923.23NoNo059
803x29 4x65 15.826112.59NoNo055
813x43 7x49 10.25896.87NoYes589
822x46 3x43 10.65542.83NoNo098
833x50 7x53 11.0134.12YesYes099
843x46 3x50 24.77083.76NoYes099
853x50 5x58 11.01556.17YesYes099
865x47 6x48 16.1982.34YesYes589
876x48 7x45 11.85848.65YesYes599
887x45 7x49 13.23936.38YesYes599
89b.l2x5 b.l4x2 17.553820.58NoYes054
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
NTNT22.162YesYes3311
LigNT48.532YesYes0301
7x24NT5.460NoYes7321
1x27NT4.472NoYes3321
1x28E22.342NoYes4421
E1x49E23.420NoYes4421
E1x50E24.642YesYes8421
3x22E24.22NoYes4421
4x64E218.092NoYes4421
4x645x3522NoNo4222
E2E249.742YesYes4411
E2E2x514.492YesNo4312
E2Lig40.872YesYes4010
E2x51E2x52112NoNo3522
E2E2x524.172YesNo4512
5x35E219.092NoYes2421
5x36E27.170NoYes4421
5x39E27.180NoYes5421
5x34E25.820NoYes1421
6x616x644.22NoNo4122
6x61E33.622NoYes4421
6x64E35.112NoYes1421
6x65Lig4.790NoYes1010
7x27E36.980NoYes4421
E3Lig14.412YesYes4010
7x34Lig3.060NoYes5010
7x31Lig1.70NoYes5010
6x63Lig1.680NoYes2010
5x32Lig1.630NoYes2010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
88.89Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
88.89Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
50.00Single4XNWMRS25004XNW-P2Y1-MRS2500
50.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
41.67Single4BWBNeurotensin4BWB-NTS1-Neurotensin
40.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
38.89Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
38.46Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
35.71Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
33.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
33.33Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
33.33Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
31.25Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
31.25Single7F1TMIP-1a7F1T-CCR5-MIP-1a
31.25Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
31.25Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
31.25Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
30.00Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
29.41Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
29.41Single4XEENeurotensin4XEE-NTS1-Neurotensin
29.41Single4XESNeurotensin4XES-NTS1-Neurotensin
29.41Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
29.41Single6YVRNTS8-136YVR-NTS1-NTS8-13
29.41Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
29.41Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
28.57Single5K2BZM2413855K2B-A2A-ZM241385-Na
28.57Single5NLXZM2413855NLX-A2A-ZM241385-Na
28.57Single5UVIZM2413855UVI-A2A-ZM241385
28.57Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
28.57Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
28.57Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
28.57Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
28.57Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
28.57Consensusgi_class-fOrthosteric Ligandgi_frizzled
28.57Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
28.57Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
27.78Single4BUONeurotensin4BUO-NTS1-Neurotensin
27.78Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
27.78Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
27.78Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
26.67Single3EMLZM2413853EML-A2A-ZM241385
26.67Single5K2AZM2413855K2A-A2A-ZM241385-Na
26.67Single5VRAZM2413855VRA-A2A-ZM241385-Na
26.67Single6LPJZM2413856LPJ-A2A-ZM241385-Na
26.67Single6LPKZM2413856LPK-A2A-ZM241385-Na
26.67Single6S0LZM2413856S0L-A2A-ZM241385
26.67Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
26.67Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
26.67Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
26.67Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
26.67Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
26.32Single6KNMJN241-96KNM-Apelin-JN241-9
26.32Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
26.32Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
26.32Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
26.32Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
25.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
25.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
25.00Single6LPLZM2413856LPL-A2A-ZM241385-Na
25.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single6S0QZM2413856S0Q-A2A-ZM241385
25.00Single6WQAZM2413856WQA-A2A-ZM241385-Na
25.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
25.00Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
25.00Single7RM5ZM2413857RM5-A2A-ZM241385-Na
25.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
25.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
25.00Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
25.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
25.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single8FYNZM2413858FYN-A2A-ZM241385-Na
25.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
25.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
25.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
25.00Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
24.00Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
24.00Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
23.81Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
23.81Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
23.81Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53Single4BV0Neurotensin4BV0-NTS1-Neurotensin
23.53Single5V57TC1145V57-SMO-TC114
23.53Single6OS1TRV0266OS1-AT1-TRV026
23.53Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
23.53Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
23.08Single4O9RCyclopamine4O9R-SMO-Cyclopamine
23.08Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
23.08Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
23.08Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
23.08Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
23.08Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
22.73Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
22.73Single7XNACYN1548067XNA-SST2-CYN154806
22.73Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
22.73Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
22.73Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
22.73Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
22.22Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
22.22Single6OS2TRV0266OS2-AT1-TRV026
22.22Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
22.22Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
22.22Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
22.22Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
22.22Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
22.22Consensusdp_offOrthosteric Liganddp2_off
22.22Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
22.22Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
22.22Consensusnts_onOrthosteric Ligandnts1_on
21.74Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
21.74Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
21.74Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
21.74Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
21.74Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
21.43Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
21.43Single4QINSAG1.54QIN-SMO-SAG1.5
21.43Single5K2DZM2413855K2D-A2A-ZM241385
21.43Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
21.43Single6JZHZM2413856JZH-A2A-ZM241385-Na
21.43Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
21.43Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
21.43Single6PS7ZM2413856PS7-A2A-ZM241385-Na
21.43Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
21.43Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
21.43Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
21.43Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
21.43Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
21.43Single8GNGIstradefylline8GNG-A2A-Istradefylline
21.43Consensusclass-f_offOrthosteric Ligandsmo_off
21.43Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
21.43Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
21.05Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
21.05Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
21.05Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
20.83Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
20.83Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
20.69Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
20.00Single5IU4ZM2413855IU4-A2A-ZM241385-Na
20.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
20.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
20.00Single5JTBZM2413855JTB-A2A-ZM241385
20.00Single5K2CZM2413855K2C-A2A-ZM241385-Na
20.00Single5NM4ZM2413855NM4-A2A-ZM241385-Na
20.00Single6MH8ZM2413856MH8-A2A-ZM241385
20.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
20.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
20.00Single7AROLUF58337ARO-A2A-LUF5833-Na
20.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
20.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
20.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
20.00Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single7SK3CXCL127SK3-ACKR3-CXCL12
20.00Single7T32ZM2413857T32-A2A-ZM241385
20.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
20.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
20.00Single7VV6C48/807VV6-MRGPRX2-C48/80
20.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
20.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
20.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
20.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
20.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
20.00Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
20.00Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
20.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
20.00Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
20.00Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
20.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
20.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
20.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
19.23Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
19.23Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
19.05Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
19.05Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
19.05Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
19.05Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
19.05Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
19.05Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
19.05Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
18.75Single4EIYZM2413854EIY-A2A-ZM241385-Na
18.75Single5IU8Q274563475IU8-A2A-Q27456347-Na
18.75Single5OLGZM2413855OLG-A2A-ZM241385-Na
18.75Single5T04Neurotensin5T04-NTS1-Neurotensin
18.75Single6D27CAY104716D27-DP2-CAY10471
18.75Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
18.75Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
18.75Single7PYRPSB-21157PYR-A2A-PSB-2115
18.75Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
18.75Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
18.75Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
18.75Consensusa2_offOrthosteric Liganda2a_off
18.75Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
18.75Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
18.52Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
18.52Single8IY6Endothelin-18IY6-ETB-Endothelin-1
18.52Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
18.52Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
18.52Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
18.18Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
18.18Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
18.18Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
18.18Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
18.18Single7SK5CXCL127SK5-ACKR3-CXCL12
18.18Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
18.18Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
18.18Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
18.18Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
18.18Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
18.18Consensussst_offOrthosteric Ligandsst2_off
17.86Single5GLHEndothelin-15GLH-ETB-Endothelin-1
17.86Single6IGKEndothelin-36IGK-ETB-Endothelin-3
17.86Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
17.65Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
17.65Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
17.65Single5N2SPSB365N2S-A1-PSB36
17.65Single5NM2ZM2413855NM2-A2A-ZM241385-Na
17.65Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
17.65Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
17.65Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
17.65Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
17.65Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
17.65Single8GNEKW-63568GNE-A2A-KW-6356-Na
17.65Single8QOTNanobody E8QOT-μ-Nanobody E
17.65Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single3OE0CVX153OE0-CXCR4-CVX15
17.39Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
17.39Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
17.39Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Consensusangiotensin_onOrthosteric Ligandat1_on
17.39Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
17.39Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
17.39Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
16.67Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
16.67Single5V56TC1145V56-SMO-TC114
16.67Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
16.67Single6JODAngiotensin II6JOD-AT2-Angiotensin II
16.67Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
16.67Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.67Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
16.67Single7PX4PSB-21137PX4-A2A-PSB-2113
16.67Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
16.67Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
16.67Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
16.67Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
16.67Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single8A2OTheophylline8A2O-A2A-Theophylline-Na
16.67Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
16.67Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
16.67Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
16.67Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
16.67Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
16.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
16.67Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
16.67Consensusadenosine_offOrthosteric Liganda1_off a2_off
16.67Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
16.67Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
16.67Consensuscck_onOrthosteric Ligandccka_on cckb_on
16.67Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
16.67Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
16.67Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
16.67Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Consensuslpa_offOrthosteric Ligandlpa1_off
16.67Consensuslpa_onOrthosteric Ligandlpa1_on
16.67Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
16.67Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
16.13Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
16.13Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
16.13Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
16.13Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
16.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
16.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
16.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
16.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
16.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
16.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
16.00Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
16.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
16.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
16.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
16.00Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
16.00Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
15.79Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
15.79Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
15.79Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
15.79Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
15.79Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
15.79Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
15.79Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
15.79Consensuschemokine_offOrthosteric Ligandcxcr_off
15.79Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
15.79Consensuscxcr_offOrthosteric Ligandcxcr4_off
15.79Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
15.79Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
15.79Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
15.38Single4XT3Fractalkine4XT3-US28-Fractalkine
15.38Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
15.38Single6FJ3PTH6FJ3-PTH1-PTH
15.38Single6LI0GTPL98046LI0-GPR52-GTPL9804
15.38Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.38Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.38Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
15.38Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
15.38Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
15.38Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
15.38Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
15.38Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
15.38Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
15.38Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
15.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
15.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
15.00Single7EZCUKA7EZC-A2A-UKA
15.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
15.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
15.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
15.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
15.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
15.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
15.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
15.00Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
15.00Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
15.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
15.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
15.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.00Consensusorexin_onOrthosteric Ligandox2_on
14.81Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
14.81Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
14.81Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
14.81Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
14.81Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
14.81Consensusendothelin_onOrthosteric Ligandetb_on eta_on
14.81Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
14.29Single4UG2CGS216804UG2-A2A-CGS21680
14.29Single5L7IVismodegib5L7I-SMO-Vismodegib
14.29Single5WF6UK-4320975WF6-A2A-UK-432097
14.29Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
14.29Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
14.29Single6IGLIRL16206IGL-ETB-IRL1620
14.29Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.29Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
14.29Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
14.29Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
14.29Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
14.29Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
14.29Single7UL2SR486927UL2-NTS1-SR48692-Na
14.29Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
14.29Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
14.29Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
14.29Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
14.29Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
14.29Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
14.29Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
14.29Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
14.29Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
14.29Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
14.29Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensuslpl_offOrthosteric Ligands1p_off lpa_off
14.29Consensuslpl_onOrthosteric Ligands1p_on lpa_on
14.29Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
13.79Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
13.79Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
13.64Single4XT1Fractalkine4XT1-US28-Fractalkine
13.64Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
13.64Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.64Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
13.64Single7F8XNN90567F8X-CCKA-NN9056
13.64Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
13.64Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
13.64Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
13.64Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
13.64Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
13.64Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
13.64Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
13.64Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
13.64Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
13.64Consensussst_onOrthosteric Ligandsst2_on sst4_on
13.33Single3PWHZM2413853PWH-A2A-ZM241385
13.33Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
13.33Single5U09Taranabant5U09-CB1-Taranabant
13.33Single7BR3Elagolix7BR3-GnRH1-Elagolix
13.33Single7F8ULintitript7F8U-CCKA-Lintitript
13.33Single7F8YDevazepide7F8Y-CCKA-Devazepide
13.33Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
13.33Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
13.33Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
13.33Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
13.33Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
13.33Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
13.33Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
13.33Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
13.33Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
13.33Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
13.33Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
13.33Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
13.33Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
13.33Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
13.33Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
13.33Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
13.33Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
13.04Single3QAKUK-4320973QAK-A2A-UK-432097
13.04Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
13.04Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
13.04Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
13.04Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
13.04Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
13.04Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
12.90Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
12.90Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
12.50Single3REYPubChem 56973REY-A2A-PubChem 5697
12.50Single5WF5UK-4320975WF5-A2A-UK-432097
12.50Single6AQFZM2413856AQF-A2A-ZM241385
12.50Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
12.50Single6D35Cholesterol6D35-SMO-Cholesterol
12.50Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
12.50Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
12.50Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
12.50Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
12.50Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
12.50Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
12.50Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
12.50Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
12.50Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
12.50Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
12.50Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
12.50Single6ZINSR486926ZIN-NTS1-SR48692
12.50Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
12.50Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
12.50Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
12.50Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
12.50Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.50Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.50Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.50Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.50Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
12.50Single7DTTCa7DTT-CaS-Ca-Ca
12.50Single7DTTCa7DTT-CaS-Ca-Ca
12.50Single7DTUTryptophan7DTU-CaS-Tryptophan
12.50Single7DTUTryptophan7DTU-CaS-Tryptophan
12.50Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
12.50Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
12.50Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
12.50Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
12.50Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
12.50Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
12.50Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
12.50Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
12.50Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
12.50Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
12.50Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
12.50Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
12.50Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
12.50Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
12.50Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
12.50Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
12.50Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
12.50Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
12.50Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
12.50Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7FIIhCG7FII-LH-hCG-6fuf
12.50Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
12.50Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
12.50Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.50Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.50Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.50Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.50Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.50Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.50Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
12.50Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
12.50Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
12.50Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
12.50Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
12.50Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
12.50Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
12.50Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
12.50Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
12.50Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
12.50Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
12.50Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
12.50Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
12.50Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
12.50Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
12.50Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
12.50Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
12.50Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
12.50Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
12.50Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
12.50Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
12.50Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
12.50Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
12.50Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
12.50Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
12.50Single7XW7K1-707XW7-TSH-K1-70
12.50Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
12.50Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
12.50Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
12.50Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
12.50Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
12.50Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
12.50Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
12.50Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
12.50Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
12.50Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
12.50Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
12.50Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
12.50Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
12.50Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
12.50Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
12.50Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
12.50Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
12.50Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
12.50Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
12.50Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
12.50Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
12.50Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
12.50Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
12.50Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
12.50Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
12.50Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
12.50Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
12.50Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
12.50Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.50Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.50Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.50Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
12.50Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
12.50Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
12.50Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
12.50Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
12.50Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
12.50Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
12.50Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
12.50Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
12.50Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
12.50Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
12.50Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
12.50Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
12.50Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
12.50Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
12.50Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
12.50Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
12.50Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
12.50Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
12.50Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
12.50Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
12.50Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
12.50Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
12.50Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
12.50Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
12.50Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
12.50Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
12.50Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
12.50Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
12.50Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
12.50Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
12.50Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
12.50Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
12.50Consensusgphr_onOrthosteric Ligandlh_on tsh_on
12.50Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
12.50Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
12.50Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
12.50Consensusgs_proteinOrthosteric Ligandgs_gphr
12.50Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
12.50Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
12.50Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
12.50Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
12.50Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
12.50Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
12.50Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
12.50Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
12.50Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
12.50Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
12.50Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
12.50Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
12.50Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
12.50Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
12.50Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
12.50Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
12.50Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
12.50Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
12.50Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
12.50Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
12.12Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
12.12Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
12.12Consensuspth_onOrthosteric Ligandpth1_on pth2_on
12.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
12.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
12.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
12.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
12.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
12.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
12.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
11.76Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
11.76Single5TGZAM65385TGZ-CB1-AM6538
11.76Single5UENDU1725UEN-A1-DU172
11.76Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
11.76Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
11.76Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
11.76Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
11.76Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
11.76Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
11.76Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
11.76Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
11.76Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
11.76Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
11.76Single8CU6LJ-45178CU6-A2A-LJ-4517
11.76Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
11.76Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
11.76Consensusadenosine_onOrthosteric Liganda1_on a2_on
11.76Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
11.76Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
11.76Consensuscck_offOrthosteric Ligandccka_off
11.76Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
11.76Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
11.76Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
11.76Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
11.76Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
11.76Consensusnucleotide_onOrthosteric Ligandadenosine_on
11.54Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
11.54Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
11.54Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
11.54Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
11.54Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
11.54Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
11.43Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
11.11Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
11.11Single5C1MBU725C1M-μ-BU72
11.11Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
11.11Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
11.11Single6D26Fevipiprant6D26-DP2-Fevipiprant
11.11Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
11.11Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
11.11Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
11.11Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
11.11Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
11.11Single6Z4SSR486926Z4S-NTS1-SR48692
11.11Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
11.11Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
11.11Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
11.11Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
11.11Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
11.11Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.11Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.11Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.11Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.11Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
11.11Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
11.11Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
11.11Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
11.11Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
11.11Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
11.11Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
11.11Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
11.11Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
11.11Single7YXAONO-54306087YXA-S1P5-ONO-5430608
11.11Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
11.11Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
11.11Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
11.11Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
11.11Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
11.11Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
11.11Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
11.11Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
11.11Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
11.11Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
11.11Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.71Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
10.71Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
10.71Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
10.71Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.71Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
10.71Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
10.71Consensusgo_class-b1Orthosteric Ligandgo_crf
10.71Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.71Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.71Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.53Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
10.53Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
10.53Single5TZR-5TZR-FFA1 (GPR40)-MK8666
10.53Single5XR8AM8415XR8-CB1-AM841
10.53Single5XRAAM115425XRA-CB1-AM11542
10.53Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
10.53Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
10.53Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
10.53Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
10.53Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
10.53Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
10.53Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
10.53Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
10.53Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
10.53Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
10.53Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
10.53Single8E0GBU728E0G-μ-BU72
10.53Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
10.53Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
10.53Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
10.53Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
10.53Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
10.53Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
10.53Consensusa2_onOrthosteric Liganda2a_on a2b_on
10.53Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
10.53Consensuschemerin_onOrthosteric Ligandcml1_on
10.53Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
10.53Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
10.53Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
10.53Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
10.53Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
10.53Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
10.53Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
10.53Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
10.53Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
10.53Consensusrelaxin_onOrthosteric Ligandrxfp4_on
10.53Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
10.34Single6LMLGlucagon6LML-Glucagon-Glucagon
10.34Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
10.34Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
10.34Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
10.34Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
10.34Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
10.34Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
10.34Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
10.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
10.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
10.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
10.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
10.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
10.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
10.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
10.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
10.00Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
10.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
10.00Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
10.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
10.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
10.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single8HS2Fab0468HS2-GPR20-Fab046
10.00Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
10.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
10.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
10.00Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
10.00Single8WU1KCA8WU1-CB1-KCA-Arrestin1
10.00Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
10.00Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
10.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
10.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
10.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
10.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
10.00Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
10.00Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
10.00Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
10.00Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
10.00Consensusnts_offOrthosteric Ligandnts1_off
10.00Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
10.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.68Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
9.68Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
9.68Consensusglp_onOrthosteric Ligandglp1_on glp2_on
9.52Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
9.52Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
9.52Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
9.52Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
9.52Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
9.52Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
9.52Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
9.52Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
9.52Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
9.52Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.52Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
9.52Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
9.52Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
9.52Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
9.52Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
9.52Consensuscyslt_offOrthosteric Ligandcyslt2_off
9.52Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
9.38Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
9.38Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
9.09Single3NY9PubChem 9131033NY9-β2-PubChem 913103
9.09Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
9.09Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
9.09Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
9.09Single7XN9L-054,5227XN9-SST2-L-054,522
9.09Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
9.09Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
9.09Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
9.09Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
9.09Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
9.09Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
9.09Consensusclass-d_offOrthosteric Ligandste2_off
9.09Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
9.09Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
9.09Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
9.09Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
9.09Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
9.09Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
8.82Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.70Single4IARErgotamine4IAR-5-HT1B-Ergotamine
8.70Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
8.70Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single7QA8Peptide7QA8-STE2-Peptide
8.70Single7QA8Peptide7QA8-STE2-Peptide
8.70Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
8.70Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
8.70Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
8.70Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
8.70Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
8.70Consensusclass-d_offOrthosteric Ligandste2_off
8.70Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
8.33Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
8.33Single5L7DCholesterol5L7D-SMO-Cholesterol
8.33Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
8.33Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
8.33Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
8.33Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
8.33Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
8.33Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
8.33Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
8.33Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
8.33Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
8.33Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
8.33Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single8PWNTheophylline8PWN-A2A-Theophylline
8.33Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
8.33Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
8.11Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
8.00Single6PT2KGCHM076PT2-δ-KGCHM07
8.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
8.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.89Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
7.89Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
7.69Single3RFMCaffeine3RFM-A2A-Caffeine
7.69Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.69Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
7.69Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
7.69Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
7.69Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
7.69Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
7.69Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
7.69Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
7.41Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
7.41Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
7.41Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
7.14Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
7.14Single3OE6IT1t3OE6-CXCR4-IT1t
7.14Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
7.14Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
7.14Single6ME5Agomelatine6ME5-MT1-Agomelatine
7.14Single6ME9Ramelteon6ME9-MT2-Ramelteon
7.14Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
7.14Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
7.14Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
7.14Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
7.14Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
7.14Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
7.14Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
7.14Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
7.14Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
7.14Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
7.14Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
7.14Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
7.14Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
7.14Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
7.14Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
7.14Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
7.14Consensusclass-d_onOrthosteric Ligandste2_on
7.14Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
6.90Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.90Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
6.90Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.90Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
6.90Consensusgi_class-dOrthosteric Ligandgi_ste
6.90Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.67Single3OE9IT1t3OE9-CXCR4-IT1t
6.67Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
6.67Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
6.67Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
6.67Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
6.67Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
6.67Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
6.67Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
6.67Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
6.67Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
6.67Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
6.67Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
6.67Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.67Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
6.67Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
6.67Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
6.67Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
6.67Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
6.67Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
6.67Single8GH1Epinephrine8GH1-β2-Epinephrine
6.67Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
6.67Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
6.67Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
6.67Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
6.67Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
6.67Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
6.67Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
6.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single8K5BNiacin8K5B-HCA2-Niacin
6.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
6.67Consensusclass-t_onOrthosteric Ligandtaste2_on
6.67Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
6.67Consensusgo_class-b2Orthosteric Ligandgo_adhesion
6.67Consensusgs_class-tOrthosteric Ligandgs_taste
6.67Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
6.67Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
6.67Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
6.45Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
6.45Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
6.45Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
6.45Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
6.45Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
6.45Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
6.25Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
6.25Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
6.25Single3ODUIT1t3ODU-CXCR4-IT1t
6.25Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
6.25Single5ZKQABT-4915ZKQ-PAF-ABT-491
6.25Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
6.25Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
6.25Single6ME2Ramelteon6ME2-MT1-Ramelteon
6.25Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
6.25Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
6.25Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
6.25Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
6.25Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
6.25Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
6.25Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
6.25Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
6.25Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
6.25Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
6.25Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
6.25Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
6.25Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
6.25Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
6.25Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
6.25Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
6.25Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
6.25Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
6.25Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
6.25Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
6.25Consensusgt_class-aOrthosteric Ligandgt_opsin
6.25Consensusgt_opsinOrthosteric Ligandgt_sensory
6.25Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
6.25Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
6.25Consensusmglu_onOther Ligandmglu2_on mglu4_on
6.25Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.06Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
5.88Single2YDOAdenosine2YDO-A2A-Adenosine
5.88Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
5.88Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
5.88Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
5.88Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
5.88Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
5.88Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
5.88Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
5.88Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
5.88Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
5.88Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
5.88Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
5.88Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
5.88Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
5.88Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
5.88Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.88Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
5.88Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
5.88Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
5.88Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
5.88Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
5.88Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
5.88Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
5.88Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.88Single8GGTEpinephrine8GGT-β2-Epinephrine
5.88Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
5.88Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
5.88Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.88Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
5.88Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
5.88Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
5.88Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
5.88Single8K2WAMG4878K2W-CXCR3-AMG487
5.88Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
5.88Single8K5CAcipimox8K5C-HCA2-Acipimox
5.88Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
5.88Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.88Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
5.88Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
5.88Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
5.88Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
5.88Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
5.88Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
5.88Consensushca_onOrthosteric Ligandhca2_on hca3_on
5.88Consensushcar_onOrthosteric Ligandhca_on
5.88Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
5.88Consensuss1p_offOrthosteric Ligands1p1_off
5.88Consensussensory_offOrthosteric Ligandopsin_off
5.56Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.56Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
5.56Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
5.56Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
5.56Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
5.56Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
5.56Single6IIVDaltroban6IIV-TP-Daltroban
5.56Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
5.56Single6PS1Timolol6PS1-β2-Timolol
5.56Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
5.56Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
5.56Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
5.56Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.56Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
5.56Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
5.56Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
5.56Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
5.56Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
5.56Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
5.56Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.56Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
5.56Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
5.56Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.56Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.56Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.56Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
5.56Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
5.56Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
5.56Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
5.56Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
5.56Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
5.56Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.56Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
5.56Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
5.56Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
5.56Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
5.56Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
5.56Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
5.56Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
5.56Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
5.56Consensusgi_hcarOrthosteric Ligandgi_hca
5.56Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
5.56Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
5.56Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
5.56Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
5.56Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
5.56Consensustar_onOrthosteric Ligandta1_on
5.56Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
5.26Single4NTJAZD12834NTJ-P2Y12-AZD1283
5.26Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
5.26Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
5.26Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
5.26Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
5.26Single6LUQHaloperidol6LUQ-D2-Haloperidol
5.26Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
5.26Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
5.26Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
5.26Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
5.26Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.26Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
5.26Single7C4SS1P7C4S-S1P3-S1P
5.26Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
5.26Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
5.26Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
5.26Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
5.26Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
5.26Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
5.26Single7XKAEpinephrine7XKA-β2-Epinephrine
5.26Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
5.26Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
5.26Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
5.26Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
5.26Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
5.26Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
5.26Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
5.26Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
5.26Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
5.26Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
5.26Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
5.26Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
5.26Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
5.26Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
5.26Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
5.26Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
5.26Consensusep_offOrthosteric Ligandep4_off
5.26Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
5.26Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
5.26Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
5.26Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
5.13Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
5.00Single2YDVNECA2YDV-A2A-NECA
5.00Single3P0GBI1671073P0G-β2-BI167107
5.00Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
5.00Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
5.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
5.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
5.00Single4UHRCGS216804UHR-A2A-CGS21680
5.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
5.00Single5G53NECA5G53-A2A-NECA-Gs
5.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
5.00Single6J21Aprepitant6J21-NK1-Aprepitant
5.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
5.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
5.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
5.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
5.00Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
5.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
5.00Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
5.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
5.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
5.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
5.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
5.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
5.00Single7W41PD1762527W41-BB2-PD176252
5.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
5.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
5.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
5.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
5.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
5.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
5.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
5.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
5.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
5.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
5.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
5.00Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
5.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
5.00Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
5.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
5.00Consensusbombesin_offOrthosteric Ligandbb2_off
5.00Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
5.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
5.00Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.00Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
5.00Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
5.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
4.88Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
4.76Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
4.76Single4N4WSANT-14N4W-SMO-SANT-1
4.76Single6A93Risperidone6A93-5-HT2A-Risperidone
4.76Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
4.76Single6CM4Risperidone6CM4-D2-Risperidone
4.76Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
4.76Single6IIURamatroban6IIU-TP-Ramatroban
4.76Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
4.76Single6MXTSalmeterol6MXT-β2-Salmeterol
4.76Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
4.76Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.76Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
4.76Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
4.76Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
4.76Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
4.76Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
4.76Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
4.76Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
4.76Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
4.76Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
4.76Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
4.76Single7YITNalfurafine7YIT-κ-Nalfurafine
4.76Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
4.76Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
4.76Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
4.76Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single8JJ8Formoterol8JJ8-β2-Formoterol
4.76Single8JJLOlodaterol8JJL-β2-Olodaterol
4.76Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
4.76Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
4.76Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
4.76Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
4.76Consensusclass-b2_onOrthosteric Ligandadgrg_on
4.76Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
4.76Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
4.76Consensusgi_class-fOther Ligandgi_frizzled
4.76Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.76Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
4.76Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
4.76Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
4.76Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
4.76Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
4.76Consensusgs_steroidOrthosteric Ligandgs_bileacid
4.76Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
4.76Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
4.76Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
4.76Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
4.55Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
4.55Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
4.55Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
4.55Single6IBLArformoterol6IBL-β1-Arformoterol
4.55Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
4.55Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
4.55Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
4.55Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
4.55Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
4.55Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
4.55Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
4.55Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
4.55Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
4.55Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
4.55Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
4.55Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
4.55Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
4.55Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
4.55Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
4.55Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
4.55Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Consensussteroid_onOrthosteric Ligandbileacid_on
4.35Single5EE7MK08935EE7-Glucagon-MK0893
4.35Single5ZTYAM102575ZTY-CB2-AM10257
4.35Single6PT3DPI-2876PT3-δ-DPI-287
4.35Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
4.35Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.35Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
4.35Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
4.35Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
4.35Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
4.35Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
4.35Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Consensusgs_class-b2Orthosteric Ligandgs_adgr
4.17Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
4.17Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
4.17Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
4.17Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
4.17Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
4.00Single6HLOAprepitant6HLO-NK1-Aprepitant
4.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
4.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
4.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
4.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
4.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
4.00Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
3.85Single6W25SHU91196W25-MC4-SHU9119-Ca
3.85Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
3.85Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
3.70Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.70Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
3.70Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
3.70Consensusclass-d_onOrthosteric Ligandste2_on
3.70Consensusgi_class-dOrthosteric Ligandgi_ste
3.70Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.70Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.57Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
3.57Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
3.45Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
3.45Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
3.33Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
3.23Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
3.12Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.94Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3

Consensus Members
Id Members
go_chemokine 6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
Net Summary
Imin 1.84
Number of Linked Nodes 795
Number of Links 908
Number of Hubs 122
Number of Links mediated by Hubs 496
Number of Communities 28
Number of Nodes involved in Communities 183
Number of Links involved in Communities 243
Path Summary
Number Of Nodes in MetaPath 90
Number Of Links MetaPath 89
Number of Shortest Paths 881294
Length Of Smallest Path 3
Average Path Length 36.5232
Length of Longest Path 70
Minimum Path Strength 1.265
Average Path Strength 4.36128
Maximum Path Strength 36.1633
Minimum Path Correlation 0.7
Average Path Correlation 0.980998
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.81818
Average % Of Corr. Nodes 44.0672
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 35.4946
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
go_class-ago_amine
go_peptide
go_protein



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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