Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.37 4.03607403
2G.HN.51 4.11464404
3G.hns1.01 8.335714184
4G.S1.02 6.87643456
5G.S1.06 5.067144208
6G.H1.01 5.446074209
7G.S3.03 6.48857558
8G.S3.04 8.95754197
9G.S3.05 4.78464408
10G.S3.06 9.054575197
11G.S3.07 5.085714209
12G.H2.03 5.9525429
13G.H2.06 6.45119629
14G.H2.07 7.44857429
15G.S4.03 4.11571407
16G.S4.04 4.68214409
17G.H3.06 5.43214406
18G.H3.09 5.19429689
19G.H3.13 7.88286686
20G.H3.17 11.1803525
21G.H3.18 5.40536409
22G.S5.04 4.65929409
23G.S5.05 5.530714109
24G.S5.07 3.84143409
25G.s5hg.01 4.172144219
26G.hgh4.05 9.52371506
27G.hgh4.08 7.74464406
28G.hgh4.11 4.03286505
29G.hgh4.20 7.56857403
30G.H4.07 8.91643485
31G.H4.08 6.63057583
32G.H4.10 11.0529407
33G.H4.12 5.85457584
34G.H4.15 7.89964408
35G.h4s6.02 4.43786487
36G.h4s6.12 4.56457502
37G.S6.02 8.005435148
38G.S6.05 7.73771585
39G.s6h5.01 5.666575109
40G.s6h5.05 4.575145109
41G.H5.03 7.149644109
42G.H5.05 5.72679455
43G.H5.06 5.871145104
44G.H5.08 5.35589858
45G.H5.17 7.509056145
46G.H5.20 4.63571468
47G.H5.25 4.51464468
48b.1x1 2.11893404
49b.1x19 5.39143406
50b.h2x5 3.62107405
51b.lhb1x3 2.70286502
52b.lhb1x6 5.7175493
53b.b1x6 8.73143439
54b.l1x3 8.96343539
55b.l1x6 10.3469529
56b.b2x1 7.21886528
57b.b2x5 6.45691637
58b.b3x3 3.928934168
59b.l3x1 8.44393429
60b.l3x2 7.488574189
61b.b4x2 4.99429408
62b.b4x6 9.03877739
63b.b4x7 8.94893438
64b.b5x2 9.00036437
65b.b5x3 6.89667639
66b.b5x7 5.78407
67b.l5x1 4.372575178
68b.l5x5 10.2763509
69b.b6x1 5.24571429
70b.b6x5 4.362295166
71b.b7x1 5.49679404
72b.b8x4 5.419435176
73b.l9x3 6.73238629
74b.l9x6 6.17225728
75b.b10x5 4.91771509
76b.l10x1 4.19321403
77b.l11x2 7.544529
78b.b12x6 7.94898728
79b.b13x7 7.67314577
80b.l13x3 7.93548679
81b.l13x6 6.042529
82b.b14x3 4.47286475
83b.b15x1 6.64976679
84b.l15x1 5.54457527
85b.l15x2 5.57771579
86b.b16x4 8.61714576
87b.b16x6 9.02214678
88b.b16x7 6.229145159
89b.b17x5 7.12143447
90b.b17x7 8.14964448
91b.l17x3 8.53673749
92b.l17x6 8.65428529
93b.b18x3 4.96464448
94b.b18x5 5.81929405
95b.l18x1 7.817866126
96b.l18x2 6.170364127
97b.l18x3 7.616074125
98b.b19x2 7.12524646
99b.b19x4 6.69607448
100b.l19x1 6.96107429
101b.l19x2 8.11543549
102b.b20x2 6.99036446
103b.b20x4 9.85071648
104b.b20x6 6.41571646
105b.b21x1 7.35743547
106b.b21x5 5.88071404
107b.b21x7 6.04143605
108b.l21x2 6.77254134
109b.l21x5 4.148214134
110b.b22x5 6.253435127
111b.l22x5 7.726599
112b.b23x6 7.834766137
113b.l23x1 6.88114526
114b.b24x4 8.784136
115b.b24x6 8.444294138
116b.l24x3 4.24286405
117b.b25x3 8.559644135
118b.l25x3 8.986575119
119b.l25x6 14.3617528
120b.l28x1 10.7592729
121b.l28x2 7.783214119
122b.b28x3 4.54714537
123b.b28x4 8.458574116
124b.b28x6 10.51114119
125g.h1x11 2.98643409
126g.h1x12 2.78286406
127g.l1x2 3.77286442
128g.l1x4 6.06143448
129g.h2x11 9.002144126
130g.ctx3 6.13114599
131g.ctx6 2.68571596
132g.ctx14 5.84714439
133g.ctx15 7.35643439
134g.ctx16 5.39661838
135Lig 16.92043310
136NT 207.621715
1371x35 4.55857415
1381x39 5.62057517
1391x43 5.55717
1401x50 4.30071409
1411x60 6.134295227
142I1x50 4.116794229
1432x39 6.79821409
1442x45 8.545364238
1452x47 4.15357409
1462x50 7.42262608
1472x51 3.50714408
1482x53 6.9049718
1492x57 4.55107417
1502x60 5.87464417
1513x32 7.80107417
1523x33 5.66679417
1533x34 6.23393409
1543x35 8.82786405
1553x40 7.82762617
1563x41 4.57786616
1573x42 11.67695239
1583x44 4.64114508
1593x46 9.29893409
1603x49 6.4481658
1613x51 9.73714468
1623x54 4.05429468
1633x55 8.62714466
164I2 5.510911157
1654x53 3.406519
1664x56 6.29679415
1674x60 6.06618
1684x64 8.71071418
169E2 6.07875816
170E2x51 10.4751518
1715x40 3.99571403
1725x41 5.90714617
1735x43 5.99679417
1745x44 8.23857417
1755x58 6.836569
1765x69 3.55536408
1776x29 2.4575406
1786x44 6.08333669
1796x47 9.37571418
1806x48 8.98694718
1816x51 5.78548617
1826x52 2.72643406
183E3 8.203711015
1847x30 9.83086515
1857x33 7.42643416
1867x36 6.65893414
1877x37 5.91229517
1887x41 6.756516
1897x43 5.28821417
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b4x2 b.l3x2 19.64876.91571YesYes089
2G.hns1.01 b.l3x2 18.0354.10714YesYes1849
3G.S1.03 G.hns1.01 20.780919.99NoYes094
4G.S1.03 G.S3.06 21.07783.81714NoYes097
5b.l27x5 g.ctx4 20.25524.79143NoNo057
6g.ctx3 g.ctx4 20.30174.6YesNo097
7g.ctx3 g.ctx5 27.92623.49YesNo999
8b.lhb1x11 g.ctx5 28.7055.45286NoNo049
9b.b25x7 b.lhb1x11 28.74676.25857NoNo074
10b.b25x7 b.b28x6 27.882817.57NoYes079
11b.b28x4 b.b28x6 50.62316.62857YesYes1169
12b.b1x5 b.b28x4 74.19917.72NoYes036
13b.b1x5 b.l1x1 74.154311.2729NoNo037
14I1x48 b.l1x1 10010.5071NoNo087
15I1x48 I1x51 99.9234.19286NoNo088
162x41 I1x51 99.84364.2NoNo078
172x41 4x43 72.09844.18429NoNo076
182x38 4x43 71.99324.84429NoNo076
192x38 3x49 71.82116.42NoYes078
203x49 I2 64.02064.54YesYes587
21G.S1.02 I2 20.88599.05YesYes567
22G.S1.02 G.S3.03 20.45446.46714YesYes568
23G.S3.01 I2 20.56238.24NoYes557
24G.S3.01 G.S3.03 20.41143.93NoYes558
25G.H5.08 I2 21.21043.76714YesYes587
26G.H5.08 G.S3.03 20.46735.36YesYes588
27G.S2.06 G.S3.03 60.393812.0971NoYes098
28G.H1.08 G.S2.06 59.91973.55429NoNo099
29G.H1.08 G.S3.05 58.99713.3NoYes098
30G.S1.04 G.S3.05 26.66363.02857NoYes078
31G.S1.04 G.S4.03 26.19445.91286NoYes077
32G.S1.06 G.S3.05 30.9648.07714YesYes088
33G.S1.06 G.S4.03 26.27233.05429YesYes087
34G.S3.06 b.l5x5 24.577416.6071YesYes079
35G.H5.07 G.S4.03 44.80184.34143NoYes097
36G.H5.07 G.S5.05 43.86053.15857NoYes099
37G.S5.05 G.s6h5.01 30.74976.67143YesYes1099
38G.S5.07 G.s6h5.01 22.49554.80571YesYes099
39G.S5.07 G.s5hg.01 10.76994.99857YesYes099
40b.b26x2 b.b2x3 12.13284.86NoNo076
41b.b26x1 b.b26x2 12.28013.19429NoNo097
42b.b26x1 b.l28x1 12.42876.53NoYes099
43b.b2x1 b.l28x1 66.6918.40571YesYes289
44b.b2x1 b.b6x1 55.20616.84143YesYes289
45b.b6x1 b.l9x6 56.32675.98571YesYes298
46G.H2.07 b.l9x6 32.17575.37429YesYes298
47G.H2.04 G.H2.07 31.86889.42857NoYes099
48G.H2.04 G.H3.08 31.66779.89143NoNo098
49b.l25x6 b.l28x1 72.936419.5614YesYes289
50b.l1x6 b.l28x1 13.028123.5386YesYes299
51b.l1x6 b.l3x1 12.66229.10429YesYes299
52b.b2x1 b.l3x1 14.118711.2714YesYes289
53G.H3.08 G.S4.04 30.47566.96143NoYes089
54G.H3.09 G.S4.04 15.33954.28714YesYes099
55G.S4.04 G.S5.04 14.75463.13143YesYes099
56G.H3.06 G.H4.14 10.11314.35714YesNo065
57G.H3.06 G.H4.15 10.5289.74143YesYes068
583x49 G.H5.23 11.73.69YesNo084
59b.l25x3 b.l28x2 28.08356.84YesYes1199
60b.b27x3 b.l25x3 50.60538.21429NoYes089
61b.b27x3 b.b28x6 25.92898.14286NoYes089
62b.b28x4 b.l25x3 25.470511.9771YesYes1169
63b.b26x3 b.b27x3 74.48063.15857NoNo068
64b.b22x2 b.b26x3 74.32765.79143NoNo086
65b.b22x1 b.b22x2 74.17783.42857NoNo088
66b.b22x1 b.l25x6 73.32067.20857NoYes288
67g.ctx3 g.ctx6 36.6474.26714YesYes996
68b.l22x5 g.ctx6 35.65893.81714YesYes996
69b.l22x5 b.lhb1x3 17.92835.72714YesYes092
70b.h2x5 b.lhb1x3 17.15223.47429YesYes052
71b.h2x1 b.h2x5 33.26893.58NoYes055
72b.b21x5 b.h2x1 32.32556.86571YesNo045
73b.b21x5 b.b21x7 30.61899.92143YesYes045
74b.b21x7 b.b23x2 25.62713.68286YesNo056
75b.b22x5 b.b23x2 25.433210.7871YesNo076
76b.b22x5 b.l18x1 22.637410.5643YesYes1276
77b.l18x1 b.l18x3 20.441410.8743YesYes1265
78b.l18x3 b.l18x4 19.31282.66571YesNo057
79b.b18x5 b.l18x4 18.91742.36714YesNo057
80b.b15x2 b.b18x5 18.32319.73857NoYes065
81b.b15x2 b.b19x2 16.080511.2386NoYes466
82b.b17x7 b.b19x2 10.57810.2586YesYes486
83b.l22x5 b.l24x2 17.23497.98286YesNo096
84b.h2x5 b.l24x2 17.05914.63286YesNo056
85b.b28x2 b.l28x2 26.146311.09NoYes049
86b.b28x2 b.l1x1 26.05698.24429NoNo047
87b.l11x1 b.l9x6 21.28147.24143NoYes298
88b.b11x6 b.l11x1 21.14263.44571NoNo299
89b.b11x6 b.l9x3 20.080814.5443NoYes299
90b.b12x6 b.l9x3 18.6565.59429YesYes289
91b.b12x6 b.b9x4 12.779419.0343YesNo089
92b.b8x1 b.b9x4 11.07423.62857NoNo089
93b.b10x3 b.b8x1 10.86043.38NoNo088
94b.b10x3 b.b6x2 10.64657.48429NoNo088
95b.b10x2 b.b6x2 10.43253.13857NoNo068
96b.b2x5 b.l27x1 11.69311.0929YesNo377
97b.b4x2 b.b5x8 17.57263.10714YesNo085
98b.b5x7 b.b5x8 17.1573.39YesNo075
99b.l27x3 b.l27x5 11.86296.93NoNo075
100b.l27x1 b.l27x3 11.71617.22857NoNo377
1012x41 2x45 28.09537.46571NoYes078
1022x45 3x42 21.723415.5671YesYes2389
1032x49 3x42 23.07296.52857NoYes099
1042x49 3x39 22.92966.38571NoNo098
1052x53 3x39 21.571311.7071YesNo088
1062x53 Lig 14.19666.66143YesYes180
107b.l3x1 b.l5x5 27.83888.60429YesYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
5x44Lig15.92711YesYes7010
E3Lig30.30141YesYes5010
7x33Lig6.425711YesYes6010
3x36Lig7.901431NoYes6010
3x40Lig4.411YesYes7010
5x47Lig4.747141NoYes7010
7x37Lig9.155711YesYes7010
7x38Lig10.39711NoYes6010
7x41Lig6.754291YesYes6010
1x43Lig7.238571YesYes7010
2x53Lig6.661431YesYes8010
2x57Lig3.728571YesYes7010
3x32Lig11.02141YesYes7010
3x33Lig4.177141YesYes7010
5x43Lig3.434291YesYes7010
7x30Lig12.58141YesYes5010
7x34Lig12.48431NoYes6010
1x32Lig24.781NoYes6010
1x35Lig3.361431YesYes5010
2x60Lig7.237141YesYes7010
2x65Lig15.67431NoYes4010
E2x52Lig9.521NoYes5010
E2Lig14.98291YesYes6010
5x41Lig5.644291YesYes7010
LigNT120.961YesYes0501
1x28Lig5.015711NoYes3010
1x29Lig7.581431NoYes3010
1x22Lig3.408571NoYes3010
NTNT654.0431YesYes5511
1x22NT6.504291NoYes3511
1x21NT11.59141NoYes3521
1x231x253.224290NoNo1121
1x28E35.315711NoYes3511
1x291x333.402861NoNo3212
1x327x304.294291NoYes6511
1x357x344.642861YesNo5611
1x357x356.611431YesNo5512
1x357x383.618571YesNo5611
1x391x435.674291YesYes7721
1x392x573.284291YesYes7721
1x397x387.005711YesNo7621
1x432x538.082861YesYes7811
1x432x543.238571YesNo7812
1x432x577.424291YesYes7711
1x437x424.542861YesNo7912
2x533x367.461431YesNo8611
2x533x3911.70711YesNo8812
2x533x408.085711YesYes8711
2x536x483.234291YesYes8812
2x537x413.101431YesYes8611
2x573x323.767141YesYes7711
2x602x643.238571YesNo7512
2x603x3211.87571YesYes7711
2x642x656.865710NoNo5421
2x64E2x526.610NoNo5521
3x26E27.414290NoYes8621
3x323x334.541YesYes7711
3x334x607.031YesYes7812
3x335x436.921YesYes7711
3x363x405.861431NoYes6711
3x405x478.811YesNo7711
3x405x513.628571YesNo7712
3x406x4816.171YesYes7812
4x565x433.164291YesYes5721
4x604x646.142861YesYes8822
4x605x4310.46861YesYes8721
4x644x683.557141YesNo8722
4x64E27.865711YesYes8621
4x68E23.398571NoYes7621
5x41E23.934291YesYes7611
5x40E26.557140YesYes3621
5x415x429.445711YesNo7812
5x415x444.068571YesYes7711
5x41E311.60291YesYes7511
5x425x448.451NoYes8721
5x44E34.508571YesYes7511
5x516x484.835711NoYes7822
6x476x4815.86571YesYes8822
6x477x414.737141YesYes8621
6x487x4111.29861YesYes8621
6x516x544.437141YesNo7522
6x517x3311.04141YesYes7621
6x517x366.641YesYes7422
6x517x374.167141YesYes7721
6x54E33.627141NoYes5521
6x547x337.897141NoYes5621
E3E34.235711YesYes5511
7x29E33.157140NoYes4521
7x30E314.31861YesYes5511
7x307x3415.45431YesNo5611
7x337x374.341431YesYes6711
7x367x374.008571YesYes4721
7x377x417.888571YesYes7611
E2NT3.874291YesYes6511
1x261x295.185710NoNo3321
E2x50E2x522.660NoNo9521
1x432x582.648571YesNo7712
7x307x312.505711YesNo5412
E1NT2.330NoYes4521
3x29Lig2.298570NoYes6010
1x25Lig1.287141NoYes1010
2x603x281.147141YesNo7612
5x385x410.7471430NoYes6721
7x27E30.7342860NoYes5521
3x21E20.6028570NoYes0621
2x68Lig0.5857140NoYes0010
2x622x650.1614290NoNo4421

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
87.10Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
84.38Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
84.38Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
83.87Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
81.82Consensuspth_onOrthosteric Ligandpth1_on pth2_on
78.12Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
74.19Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
71.88Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
71.88Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
71.88Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
71.05Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
67.65Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
67.57Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
66.67Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
65.62Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
65.62Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
64.71Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
64.52Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
63.64Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
61.76Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
61.76Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
61.76Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
60.61Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
60.61Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
59.46Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
58.82Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
58.33Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
57.58Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
57.58Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
57.14Single6LMLGlucagon6LML-Glucagon-Glucagon
57.14Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
55.88Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
55.88Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
55.88Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
55.88Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
55.88Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
55.88Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
55.88Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
55.26Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
55.00Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
54.55Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
54.29Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
53.66Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
52.94Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
52.94Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
52.94Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
52.78Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
51.52Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
51.43Single6FJ3PTH6FJ3-PTH1-PTH
51.43Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
51.43Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
51.35Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
50.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
50.00Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
50.00Consensusglp_onOrthosteric Ligandglp1_on glp2_on
50.00Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
48.72Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
48.57Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
48.48Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
47.22Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
47.06Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
46.34Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
45.95Consensusgo_class-b1Orthosteric Ligandgo_crf
45.95Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
45.71Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
45.00Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
44.12Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
43.90Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
43.59Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
43.59Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
43.59Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
43.59Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
42.86Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
42.11Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
42.11Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
41.67Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
41.67Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
41.67Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
41.67Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
41.46Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
41.03Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
41.03Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
39.39Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
39.13Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
39.02Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
38.46Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
38.46Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
38.46Consensusgi_class-dOrthosteric Ligandgi_ste
38.46Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
38.46Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
37.50Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
37.14Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
37.14Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
35.90Consensusclass-d_onOrthosteric Ligandste2_on
34.29Consensusclass-d_offOrthosteric Ligandste2_off
33.33Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
33.33Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
33.33Single7QA8Peptide7QA8-STE2-Peptide
33.33Single7QA8Peptide7QA8-STE2-Peptide
33.33Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
33.33Consensusclass-d_offOrthosteric Ligandste2_off
33.33Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
32.43Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
32.35Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
32.35Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
32.35Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
32.35Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
31.82Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
31.11Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
30.95Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
30.95Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
30.77Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.56Single5EE7MK08935EE7-Glucagon-MK0893
30.56Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
30.30Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
30.23Single6IGKEndothelin-36IGK-ETB-Endothelin-3
30.23Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
30.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
30.00Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
29.73Single4XT1Fractalkine4XT1-US28-Fractalkine
29.41Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
29.27Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
28.95Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
28.95Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
28.57Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
28.57Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
28.57Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
28.57Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
28.57Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
28.57Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
28.57Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
28.21Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
28.21Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
28.21Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
28.12Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
28.12Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
27.91Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
27.91Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
27.91Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
27.91Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
27.91Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
27.78Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
27.78Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
27.78Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
27.78Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
27.78Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
27.78Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
27.50Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
27.50Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single5GLHEndothelin-15GLH-ETB-Endothelin-1
27.27Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
27.27Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
27.03Single4UG2CGS216804UG2-A2A-CGS21680
27.03Single5ZTYAM102575ZTY-CB2-AM10257
27.03Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
27.03Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
27.03Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
27.03Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
27.03Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
27.03Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
27.03Consensusgs_class-b2Orthosteric Ligandgs_adgr
27.03Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
26.83Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
26.83Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
26.83Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
26.47Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
26.47Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
26.47Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
26.32Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
26.32Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
26.32Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
26.32Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
26.32Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
26.32Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
26.19Single4XT3Fractalkine4XT3-US28-Fractalkine
26.19Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
26.19Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
26.19Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.19Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
26.09Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
25.71Single5XR8AM8415XR8-CB1-AM841
25.71Single5XRAAM115425XRA-CB1-AM11542
25.71Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
25.71Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
25.71Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
25.71Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
25.71Single8E0GBU728E0G-μ-BU72
25.71Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
25.64Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
25.64Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
25.64Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
25.64Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.64Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
25.64Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
25.58Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
25.58Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
25.58Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
25.53Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.53Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.53Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
25.49Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
25.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
25.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
25.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
25.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
25.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
25.00Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
25.00Single8WU1KCA8WU1-CB1-KCA-Arrestin1
25.00Consensusangiotensin_onOrthosteric Ligandat1_on
25.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.00Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
25.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
25.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
25.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
25.00Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.00Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
25.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
24.49Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
24.44Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
24.44Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
24.44Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
24.39Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
24.39Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
24.39Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
24.39Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
24.32Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
24.32Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
24.32Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
24.32Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
24.32Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
24.32Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
24.32Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
24.32Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
24.32Consensusorexin_onOrthosteric Ligandox2_on
24.32Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
24.24Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
24.24Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
23.81Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
23.81Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
23.81Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.68Single3NY9PubChem 9131033NY9-β2-PubChem 913103
23.68Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
23.68Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
23.68Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
23.68Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
23.68Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
23.68Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
23.68Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
23.68Consensuslpl_offOrthosteric Ligands1p_off lpa_off
23.68Consensuslpl_onOrthosteric Ligands1p_on lpa_on
23.68Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
23.53Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
23.53Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
23.53Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
23.53Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
23.53Consensusgi_hcarOrthosteric Ligandgi_hca
23.53Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
23.53Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
23.26Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
23.26Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
23.26Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
23.26Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
23.26Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
23.26Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
23.26Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
23.08Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
23.08Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
23.08Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
23.08Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
23.08Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.08Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
23.08Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
23.08Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
23.08Consensussst_onOrthosteric Ligandsst2_on sst4_on
22.92Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.92Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
22.86Single5C1MBU725C1M-μ-BU72
22.86Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
22.86Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
22.86Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
22.86Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
22.86Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
22.86Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
22.86Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.86Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
22.86Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.86Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
22.86Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
22.86Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
22.73Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
22.73Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
22.73Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
22.73Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
22.50Single3QAKUK-4320973QAK-A2A-UK-432097
22.50Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
22.50Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
22.50Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
22.50Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
22.50Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
22.22Single2YDVNECA2YDV-A2A-NECA
22.22Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
22.22Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
22.22Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
22.22Single4UHRCGS216804UHR-A2A-CGS21680
22.22Single5G53NECA5G53-A2A-NECA-Gs
22.22Single6IGLIRL16206IGL-ETB-IRL1620
22.22Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
22.22Single7EPENAM5637EPE-mGlu-NAM563
22.22Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
22.22Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
22.22Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.22Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
22.22Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
22.22Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
22.22Single8IY6Endothelin-18IY6-ETB-Endothelin-1
22.22Consensuscck_onOrthosteric Ligandccka_on cckb_on
22.22Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
22.22Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
22.22Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
22.22Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
21.95Single5WF5UK-4320975WF5-A2A-UK-432097
21.95Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
21.95Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
21.95Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
21.95Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
21.95Single7XNACYN1548067XNA-SST2-CYN154806
21.95Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
21.95Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.95Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
21.88Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.88Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.88Single8GH1Epinephrine8GH1-β2-Epinephrine
21.74Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
21.74Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
21.62Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
21.62Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.62Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
21.62Single7DFPSpiperone7DFP-D2-Spiperone
21.62Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
21.62Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
21.62Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.62Single7YITNalfurafine7YIT-κ-Nalfurafine
21.62Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
21.62Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
21.62Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
21.62Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.62Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
21.62Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
21.62Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
21.62Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
21.62Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
21.62Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
21.62Consensusdp_offOrthosteric Liganddp2_off
21.62Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
21.62Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
21.62Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
21.43Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
21.43Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.43Single7C61Ergotamine7C61-5-HT1B-Ergotamine
21.43Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
21.43Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
21.43Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
21.43Consensusclass-d_onOrthosteric Ligandste2_on
21.43Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
21.43Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
21.43Consensusgi_class-dOrthosteric Ligandgi_ste
21.43Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
21.43Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.28Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
21.21Single5U09Taranabant5U09-CB1-Taranabant
21.21Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
21.21Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
21.21Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.21Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
21.15Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
21.05Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
21.05Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
21.05Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
21.05Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
21.05Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
21.05Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
21.05Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
21.05Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
21.05Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
21.05Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
21.05Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.05Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
21.05Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
21.05Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
21.05Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
21.05Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
21.05Consensusendothelin_offOrthosteric Ligandetb_off
21.05Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
21.05Consensussteroid_onOrthosteric Ligandbileacid_on
20.93Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.93Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.93Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.93Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
20.93Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
20.93Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.93Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.93Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.93Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.93Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
20.59Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
20.59Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.59Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
20.59Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
20.59Single8GGTEpinephrine8GGT-β2-Epinephrine
20.59Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
20.59Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
20.59Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
20.59Single8K5CAcipimox8K5C-HCA2-Acipimox
20.59Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.59Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.59Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
20.59Consensushca_onOrthosteric Ligandhca2_on hca3_on
20.59Consensushcar_onOrthosteric Ligandhca_on
20.59Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
20.59Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
20.59Consensuss1p_offOrthosteric Ligands1p1_off
20.51Single5WF6UK-4320975WF6-A2A-UK-432097
20.51Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
20.51Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
20.51Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
20.51Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.51Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
20.51Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.51Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
20.51Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.51Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
20.51Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
20.51Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.51Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
20.51Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.51Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
20.45Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
20.45Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.45Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.45Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
20.45Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
20.37Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
20.00Single2Y04Salbutamol2Y04-β1-Salbutamol
20.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
20.00Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
20.00Single5TGZAM65385TGZ-CB1-AM6538
20.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
20.00Single6TOTLemborexant6TOT-OX1-Lemborexant
20.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
20.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
20.00Single7UL4Alvimopan7UL4-μ-Alvimopan
20.00Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
20.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
20.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
20.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
20.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
20.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
20.00Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
20.00Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
20.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
20.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
20.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
20.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
20.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
20.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
19.57Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
19.57Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
19.57Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
19.57Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
19.51Single6HLOAprepitant6HLO-NK1-Aprepitant
19.51Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
19.51Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
19.51Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
19.51Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
19.51Consensussst_offOrthosteric Ligandsst2_off
19.44Single2Y03Isoprenaline2Y03-β1-Isoprenaline
19.44Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
19.44Single5TVNLSD5TVN-5-HT2B-LSD
19.44Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
19.44Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
19.44Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
19.44Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
19.44Single6TP6Filorexant6TP6-OX1-Filorexant
19.44Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
19.44Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
19.44Single7C4SS1P7C4S-S1P3-S1P
19.44Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
19.44Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
19.44Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
19.44Single7XKAEpinephrine7XKA-β2-Epinephrine
19.44Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
19.44Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
19.44Single7YXAONO-54306087YXA-S1P5-ONO-5430608
19.44Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
19.44Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.44Single8EA0Iperoxo8EA0-M3-Iperoxo
19.44Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
19.44Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
19.44Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
19.44Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
19.44Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
19.44Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
19.44Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
19.44Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
19.44Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.44Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.44Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.44Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
19.44Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
19.44Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
19.44Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
19.44Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
19.44Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
19.44Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
19.44Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
19.15Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
19.05Single3OE0CVX153OE0-CXCR4-CVX15
19.05Single6PT2KGCHM076PT2-δ-KGCHM07
19.05Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
19.05Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
19.05Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
18.92Single3P0GBI1671073P0G-β2-BI167107
18.92Single4DJHJDTic4DJH-κ-JDTic
18.92Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
18.92Single4RWADIPP-NH24RWA-δ-DIPP-NH2
18.92Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
18.92Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
18.92Single5V54Methiothepin5V54-5-HT1B-Methiothepin
18.92Single5X93K-87945X93-ETB-K-8794
18.92Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
18.92Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
18.92Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
18.92Single6H7JIsoprenaline6H7J-β1-Isoprenaline
18.92Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
18.92Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
18.92Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
18.92Single6WGTLSD6WGT-5-HT2A-LSD
18.92Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
18.92Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
18.92Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
18.92Single7TUYGSK682753A7TUY-GPR183-GSK682753A
18.92Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
18.92Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.92Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
18.92Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
18.92Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
18.92Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
18.92Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
18.92Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
18.92Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
18.92Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
18.92Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
18.92Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
18.92Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
18.92Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
18.92Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
18.92Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.92Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
18.92Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
18.92Consensus5ht1_offOrthosteric Ligand5ht1b_off
18.92Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
18.92Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
18.92Consensusa2_onOrthosteric Liganda2a_on a2b_on
18.92Consensusadenosine_offOrthosteric Liganda1_off a2_off
18.92Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
18.92Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
18.92Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
18.92Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
18.92Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
18.92Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.92Consensuslpa_offOrthosteric Ligandlpa1_off
18.92Consensuslpa_onOrthosteric Ligandlpa1_on
18.92Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
18.92Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
18.92Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
18.92Consensusrelaxin_onOrthosteric Ligandrxfp4_on
18.92Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
18.75Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
18.75Single8GGREpinephrine8GGR-β2-Epinephrine
18.75Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
18.75Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
18.75Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
18.60Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
18.60Single6JODAngiotensin II6JOD-AT2-Angiotensin II
18.60Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
18.60Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
18.60Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
18.42Single4LDEBI1671074LDE-β2-BI167107
18.42Single4N4WSANT-14N4W-SMO-SANT-1
18.42Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
18.42Single4XEENeurotensin4XEE-NTS1-Neurotensin
18.42Single4XESNeurotensin4XES-NTS1-Neurotensin
18.42Single5CXVTiotropium5CXV-M1-Tiotropium
18.42Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
18.42Single6A93Risperidone6A93-5-HT2A-Risperidone
18.42Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
18.42Single6MXTSalmeterol6MXT-β2-Salmeterol
18.42Single6OS2TRV0266OS2-AT1-TRV026
18.42Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
18.42Single6YVRNTS8-136YVR-NTS1-NTS8-13
18.42Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
18.42Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
18.42Single7K15MKD0467K15-BLT1-MKD046-Na
18.42Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
18.42Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.42Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
18.42Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
18.42Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
18.42Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
18.42Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
18.42Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
18.42Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
18.42Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
18.42Single8JJ8Formoterol8JJ8-β2-Formoterol
18.42Single8JJLOlodaterol8JJL-β2-Olodaterol
18.42Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.42Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
18.42Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
18.42Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
18.42Consensusblt_offOrthosteric Ligandblt1_off
18.42Consensusclass-b2_onOrthosteric Ligandadgrg_on
18.42Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
18.42Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
18.42Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
18.42Consensusgs_steroidOrthosteric Ligandgs_bileacid
18.42Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
18.42Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
18.42Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
18.42Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
18.42Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
18.37Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
18.37Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
18.37Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single3OE9IT1t3OE9-CXCR4-IT1t
18.18Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
18.18Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
18.18Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
18.18Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
18.18Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
18.18Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
18.18Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
18.18Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
18.18Single8GGSEpinephrine8GGS-β2-Epinephrine
18.18Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
18.18Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
18.18Single8K5BNiacin8K5B-HCA2-Niacin
18.18Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
18.18Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Consensusclass-t_onOrthosteric Ligandtaste2_on
18.18Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensusgs_class-tOrthosteric Ligandgs_taste
18.18Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
18.18Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
18.00Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
17.95Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
17.95Single4BUONeurotensin4BUO-NTS1-Neurotensin
17.95Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.95Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
17.95Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
17.95Single6K1QIRL25006K1Q-ETB-IRL2500
17.95Single7EZCUKA7EZC-A2A-UKA
17.95Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
17.95Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
17.95Single7UM4AS26747237UM4-5-HT5A-AS2674723
17.95Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
17.95Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
17.95Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
17.95Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
17.95Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.95Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
17.95Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
17.95Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.95Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
17.95Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.78Single7SK3CXCL127SK3-ACKR3-CXCL12
17.78Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
17.78Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.78Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
17.78Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
17.65Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
17.65Single6AKXA4R6AKX-CCR5-A4R
17.65Single6AKYMaraviroc6AKY-CCR5-Maraviroc
17.65Single6B73PubChem 1319551386B73-κ-PubChem 131955138
17.65Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
17.65Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
17.65Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
17.65Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
17.65Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
17.65Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
17.65Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
17.65Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
17.65Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
17.65Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
17.65Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.65Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.65Single8GGVEpinephrine8GGV-β2-Epinephrine
17.65Single8GGWEpinephrine8GGW-β2-Epinephrine
17.65Single8GGXEpinephrine8GGX-β2-Epinephrine
17.65Single8GH0Epinephrine8GH0-β2-Epinephrine
17.65Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
17.65Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single8IWESpermidine8IWE-TAAR9-Spermidine
17.65Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
17.65Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.65Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.65Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
17.65Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
17.65Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
17.65Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
17.65Consensusmglu_onOther Ligandmglu2_on mglu4_on
17.65Consensusorexin_offOrthosteric Ligandox2_off ox1_off
17.50Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
17.50Single6PT3DPI-2876PT3-δ-DPI-287
17.50Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
17.50Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.50Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
17.50Single7SK9CCX6627SK9-ACKR3-CCX662
17.50Single7XN9L-054,5227XN9-SST2-L-054,522
17.50Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
17.50Single8X5YAstemizole8X5Y-H1-Astemizole
17.50Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
17.50Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
17.50Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
17.50Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.50Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Consensusendothelin_onOrthosteric Ligandetb_on eta_on
17.39Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
17.39Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.31Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
17.14Single2YDOAdenosine2YDO-A2A-Adenosine
17.14Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
17.14Single4MBSMaraviroc4MBS-CCR5-Maraviroc
17.14Single4ZJCSB-6740424ZJC-OX1-SB-674042
17.14Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
17.14Single6PS4ICI 118-5516PS4-β2-ICI 118-551
17.14Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
17.14Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
17.14Single6TPGEMPA6TPG-OX2-EMPA
17.14Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
17.14Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
17.14Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
17.14Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
17.14Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
17.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
17.14Single7T32ZM2413857T32-A2A-ZM241385
17.14Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
17.14Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
17.14Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
17.14Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
17.14Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
17.14Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
17.14Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
17.14Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
17.14Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
17.14Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
17.14Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.14Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.14Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.14Single8GGIEpinephrine8GGI-β2-Epinephrine
17.14Single8GGKEpinephrine8GGK-β2-Epinephrine
17.14Single8GGLEpinephrine8GGL-β2-Epinephrine
17.14Single8GGMEpinephrine8GGM-β2-Epinephrine
17.14Single8GGPEpinephrine8GGP-β2-Epinephrine
17.14Single8GGQEpinephrine8GGQ-β2-Epinephrine
17.14Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
17.14Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.14Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.14Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
17.14Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.14Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
17.14Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
17.14Consensusgnrh_offOrthosteric Ligandgnrh1_off
17.14Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
17.14Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
17.14Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
17.14Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
17.14Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
17.07Single4IARErgotamine4IAR-5-HT1B-Ergotamine
17.07Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
17.07Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
17.07Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
17.07Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
17.07Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
17.07Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
17.07Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
17.07Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
17.07Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
17.07Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
17.02Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single3NY8ICI 118-5513NY8-β2-ICI 118-551
16.67Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
16.67Single4DAJTiotropium4DAJ-M3-Tiotropium
16.67Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
16.67Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
16.67Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
16.67Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
16.67Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
16.67Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
16.67Single4YAYZD-71554YAY-AT1-ZD-7155
16.67Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
16.67Single5UENDU1725UEN-A1-DU172
16.67Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
16.67Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
16.67Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
16.67Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
16.67Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
16.67Single6GPSMK08126GPS-CCR2-MK0812
16.67Single6H7MSalbutamol6H7M-β1-Salbutamol
16.67Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
16.67Single6PS1Timolol6PS1-β2-Timolol
16.67Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
16.67Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
16.67Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
16.67Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
16.67Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
16.67Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
16.67Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
16.67Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
16.67Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
16.67Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
16.67Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
16.67Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
16.67Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
16.67Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
16.67Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
16.67Single7SK5CXCL127SK5-ACKR3-CXCL12
16.67Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
16.67Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
16.67Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
16.67Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
16.67Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
16.67Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
16.67Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
16.67Single7WC7Lisuride7WC7-5-HT2A-Lisuride
16.67Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GGJEpinephrine8GGJ-β2-Epinephrine
16.67Single8GGNEpinephrine8GGN-β2-Epinephrine
16.67Single8GGOEpinephrine8GGO-β2-Epinephrine
16.67Single8GGUEpinephrine8GGU-β2-Epinephrine
16.67Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
16.67Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
16.67Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
16.67Single8K5DGSK2560738K5D-HCA2-GSK256073
16.67Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
16.67Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
16.67Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
16.67Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
16.67Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
16.67Consensusadenosine_onOrthosteric Liganda1_on a2_on
16.67Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
16.67Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
16.67Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
16.67Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
16.67Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
16.67Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
16.67Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
16.67Consensusnucleotide_onOrthosteric Ligandadenosine_on
16.67Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
16.67Consensustar_onOrthosteric Ligandta1_on
16.67Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
16.33Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
16.28Single6W25SHU91196W25-MC4-SHU9119-Ca
16.28Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
16.28Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
16.28Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
16.28Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
16.22Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
16.22Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
16.22Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
16.22Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
16.22Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
16.22Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
16.22Single5N2SPSB365N2S-A1-PSB36
16.22Single5NM2ZM2413855NM2-A2A-ZM241385-Na
16.22Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
16.22Single5WIUNemonapride5WIU-D4-Nemonapride
16.22Single5WIVNemonapride5WIV-D4-Nemonapride-Na
16.22Single5WQCEMPA5WQC-OX2-EMPA
16.22Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
16.22Single5XPRBosentan5XPR-ETB-Bosentan
16.22Single6D26Fevipiprant6D26-DP2-Fevipiprant
16.22Single6E67BI1671076E67-β2-BI167107-Gs (fused)
16.22Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
16.22Single6GPXMK08126GPX-CCR2-MK0812
16.22Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
16.22Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
16.22Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
16.22Single6PS6Timolol6PS6-β2-Timolol
16.22Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
16.22Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
16.22Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
16.22Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
16.22Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
16.22Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
16.22Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
16.22Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
16.22Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
16.22Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
16.22Single8QOTNanobody E8QOT-μ-Nanobody E
16.22Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
16.22Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
16.22Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
16.22Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
16.22Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
16.22Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
16.22Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
16.22Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
16.22Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
16.22Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
16.22Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
16.22Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
16.22Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
16.13Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
15.91Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
15.91Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
15.91Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
15.91Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
15.91Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.91Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
15.79Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
15.79Single4BV0Neurotensin4BV0-NTS1-Neurotensin
15.79Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
15.79Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
15.79Single4U15Tiotropium4U15-M3-Tiotropium
15.79Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
15.79Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
15.79Single5V56TC1145V56-SMO-TC114
15.79Single5V57TC1145V57-SMO-TC114
15.79Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
15.79Single6J21Aprepitant6J21-NK1-Aprepitant
15.79Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
15.79Single6OL9Tiotropium6OL9-M5-Tiotropium
15.79Single6TQ7SB-3348676TQ7-OX1-SB-334867
15.79Single7B6WCyclazosin7B6W-α1b-Cyclazosin
15.79Single7F1TMIP-1a7F1T-CCR5-MIP-1a
15.79Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
15.79Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
15.79Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
15.79Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
15.79Single7PX4PSB-21137PX4-A2A-PSB-2113
15.79Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
15.79Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
15.79Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
15.79Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
15.79Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
15.79Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
15.79Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
15.79Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
15.79Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
15.79Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
15.79Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
15.79Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
15.79Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
15.79Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
15.79Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
15.79Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
15.79Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
15.79Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
15.79Consensus5ht5_offOrthosteric Ligand5ht5a_off
15.79Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
15.79Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
15.79Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
15.79Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
15.79Consensuschemerin_onOrthosteric Ligandcml1_on
15.79Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
15.79Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
15.79Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
15.79Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
15.79Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
15.79Consensushistamine_offOrthosteric Ligandh1_off
15.79Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
15.79Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
15.69Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
15.62Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
15.56Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
15.56Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
15.56Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
15.56Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
15.38Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
15.38Single4AMIBucindolol4AMI-β1-Bucindolol
15.38Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
15.38Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
15.38Single6CM4Risperidone6CM4-D2-Risperidone
15.38Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
15.38Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
15.38Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
15.38Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
15.38Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
15.38Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
15.38Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.38Single6ZG4HTL00099366ZG4-M1-HTL0009936
15.38Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
15.38Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
15.38Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.38Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
15.38Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
15.38Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
15.38Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
15.38Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
15.38Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
15.38Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
15.38Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
15.38Single8JWZAB9288JWZ-A2A-AB928-Na
15.38Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
15.38Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
15.38Consensusgi_class-fOther Ligandgi_frizzled
15.38Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.38Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
15.38Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.38Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.15Single3OE6IT1t3OE6-CXCR4-IT1t
15.15Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
15.15Single8GGZEpinephrine8GGZ-β2-Epinephrine
15.15Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
15.00Single5CGDHTL142425CGD-mGlu5-HTL14242
15.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
15.00Single6H7LDobutamine6H7L-β1-Dobutamine
15.00Single6IBLArformoterol6IBL-β1-Arformoterol
15.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
15.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
15.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
15.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
15.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
15.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
15.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
15.00Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
15.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
15.00Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
15.00Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
14.71Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
14.71Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
14.71Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
14.71Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
14.71Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
14.71Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
14.71Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.71Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.71Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.71Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
14.71Single8GGYEpinephrine8GGY-β2-Epinephrine
14.71Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
14.71Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
14.71Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
14.71Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
14.71Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
14.71Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
14.71Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.71Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
14.71Consensusgo_class-b2Orthosteric Ligandgo_adhesion
14.63Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
14.63Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.63Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.63Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
14.63Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.63Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.63Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
14.63Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
14.29Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
14.29Single3ODUIT1t3ODU-CXCR4-IT1t
14.29Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
14.29Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
14.29Single4BWBNeurotensin4BWB-NTS1-Neurotensin
14.29Single4S0VSuvorexant4S0V-OX2-Suvorexant
14.29Single5K2DZM2413855K2D-A2A-ZM241385
14.29Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
14.29Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
14.29Single5WS3EMPA5WS3-OX2-EMPA
14.29Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
14.29Single6JZHZM2413856JZH-A2A-ZM241385-Na
14.29Single6KUXRS-799486KUX-α2a-RS-79948
14.29Single6ME2Ramelteon6ME2-MT1-Ramelteon
14.29Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
14.29Single6PS7ZM2413856PS7-A2A-ZM241385-Na
14.29Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
14.29Single6TODEMPA6TOD-OX1-EMPA-Na
14.29Single6TPJSuvorexant6TPJ-OX2-Suvorexant
14.29Single7BR3Elagolix7BR3-GnRH1-Elagolix
14.29Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
14.29Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
14.29Single7F8XNN90567F8X-CCKA-NN9056
14.29Single7F8YDevazepide7F8Y-CCKA-Devazepide
14.29Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
14.29Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
14.29Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
14.29Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
14.29Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
14.29Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
14.29Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
14.29Single7XRRLemborexant7XRR-OX2-Lemborexant
14.29Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
14.29Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
14.29Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GNGIstradefylline8GNG-A2A-Istradefylline
14.29Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
14.29Single8IHKAcifran8IHK-HCA3-Acifran
14.29Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
14.29Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
14.29Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
14.29Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
14.29Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
14.29Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
14.29Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
14.29Consensusalpha1_onOrthosteric Ligandalpha1a_on
14.29Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
14.29Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
14.29Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
14.29Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgt_class-aOrthosteric Ligandgt_opsin
14.29Consensusgt_opsinOrthosteric Ligandgt_sensory
14.29Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
14.29Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
14.29Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
13.95Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
13.95Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
13.95Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
13.95Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
13.89Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
13.89Single5IU4ZM2413855IU4-A2A-ZM241385-Na
13.89Single5IU7Q274563465IU7-A2A-Q27456346-Na
13.89Single5IUBQ274563445IUB-A2A-Q27456344-Na
13.89Single5JTBZM2413855JTB-A2A-ZM241385
13.89Single5K2BZM2413855K2B-A2A-ZM241385-Na
13.89Single5K2CZM2413855K2C-A2A-ZM241385-Na
13.89Single5NLXZM2413855NLX-A2A-ZM241385-Na
13.89Single5NM4ZM2413855NM4-A2A-ZM241385-Na
13.89Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
13.89Single6A94Zotepine6A94-5-HT2A-Zotepine
13.89Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
13.89Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
13.89Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
13.89Single6TP3Nemorexant6TP3-OX1-Nemorexant
13.89Single6TPNHTL66416TPN-OX2-HTL6641
13.89Single6V9SGTPL114036V9S-OX1-GTPL11403
13.89Single6VI4JDTic6VI4-κ-JDTic
13.89Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
13.89Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
13.89Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
13.89Single6ZG9GSK10347026ZG9-M1-GSK1034702
13.89Single7AROLUF58337ARO-A2A-LUF5833-Na
13.89Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
13.89Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
13.89Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
13.89Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
13.89Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
13.89Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
13.89Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.89Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.89Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
13.89Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
13.89Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
13.89Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
13.89Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
13.89Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
13.89Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
13.89Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.89Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.89Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.89Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.89Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.89Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
13.89Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
13.89Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
13.89Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
13.89Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
13.89Single8K2WAMG4878K2W-CXCR3-AMG487
13.89Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.89Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.89Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
13.89Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.89Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.89Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
13.89Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.89Consensus5ht5_onOrthosteric Ligand5ht5a_on
13.89Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
13.89Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
13.89Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
13.89Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
13.89Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
13.89Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
13.89Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
13.64Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
13.64Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.51Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
13.51Single2Y01Dobutamine2Y01-β1-Dobutamine
13.51Single2Y02Carmoterol2Y02-β1-Carmoterol
13.51Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
13.51Single3EMLZM2413853EML-A2A-ZM241385
13.51Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
13.51Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
13.51Single4EIYZM2413854EIY-A2A-ZM241385-Na
13.51Single4EJ4Naltrindole4EJ4-δ-Naltrindole
13.51Single4MQSIperoxo4MQS-M2-Iperoxo
13.51Single4U14Tiotropium4U14-M3-Tiotropium
13.51Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
13.51Single5DSGTiotropium5DSG-M4-Tiotropium
13.51Single5IU8Q274563475IU8-A2A-Q27456347-Na
13.51Single5K2AZM2413855K2A-A2A-ZM241385-Na
13.51Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
13.51Single5OLGZM2413855OLG-A2A-ZM241385-Na
13.51Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
13.51Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
13.51Single5T04Neurotensin5T04-NTS1-Neurotensin
13.51Single5VRAZM2413855VRA-A2A-ZM241385-Na
13.51Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
13.51Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
13.51Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
13.51Single6D27CAY104716D27-DP2-CAY10471
13.51Single6DRXLisuride6DRX-5-HT2B-Lisuride
13.51Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
13.51Single6LPJZM2413856LPJ-A2A-ZM241385-Na
13.51Single6LPKZM2413856LPK-A2A-ZM241385-Na
13.51Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
13.51Single6S0LZM2413856S0L-A2A-ZM241385
13.51Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
13.51Single7BU7BI1671077BU7-β1-BI167107
13.51Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
13.51Single7F83PF-051904577F83-Ghrelin-PF-05190457
13.51Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.51Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
13.51Single7PYRPSB-21157PYR-A2A-PSB-2115
13.51Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
13.51Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
13.51Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
13.51Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
13.51Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
13.51Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
13.51Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
13.51Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.51Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
13.51Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
13.51Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
13.51Single8CU6LJ-45178CU6-A2A-LJ-4517
13.51Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
13.51Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
13.51Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
13.51Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
13.51Single8JJOAlprenolol8JJO-β2-Alprenolol
13.51Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
13.51Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
13.51Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
13.51Single8X63Mepyramine8X63-H1-Mepyramine
13.51Single8X64Desloratadine8X64-H1-Desloratadine
13.51Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
13.51Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
13.51Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
13.51Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
13.51Consensusa2_offOrthosteric Liganda2a_off
13.51Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
13.51Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
13.51Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
13.51Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
13.51Consensusblt_onOrthosteric Ligandblt1_on
13.51Consensuscck_offOrthosteric Ligandccka_off
13.51Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
13.51Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
13.51Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.51Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
13.51Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.51Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
13.51Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
13.51Consensushistamine_onOrthosteric Ligandh1_on h4_on
13.51Consensusleuko_onOrthosteric Ligandblt_on
13.51Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
13.51Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
13.51Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
13.51Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
13.51Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
13.33Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.16Single2Y00Dobutamine2Y00-β1-Dobutamine
13.16Single5CGCHTL142425CGC-mGlu5-HTL14242
13.16Single5IUAQ274563485IUA-A2A-Q27456348-Na
13.16Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
13.16Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
13.16Single6LPLZM2413856LPL-A2A-ZM241385-Na
13.16Single6LUQHaloperidol6LUQ-D2-Haloperidol
13.16Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
13.16Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
13.16Single6S0QZM2413856S0Q-A2A-ZM241385
13.16Single6WQAZM2413856WQA-A2A-ZM241385-Na
13.16Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
13.16Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
13.16Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.16Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.16Single7RM5ZM2413857RM5-A2A-ZM241385-Na
13.16Single7SINNPS-21437SIN-CaS-NPS-2143
13.16Single7SINNPS-21437SIN-CaS-NPS-2143
13.16Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
13.16Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
13.16Single7WC6LSD7WC6-5-HT2A-LSD
13.16Single8FYNZM2413858FYN-A2A-ZM241385-Na
13.16Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
13.16Single8GNEKW-63568GNE-A2A-KW-6356-Na
13.16Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
13.16Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
13.16Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
13.16Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
13.16Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
13.16Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.16Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.82Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
12.82Single6J20Aprepitant6J20-NK1-Aprepitant
12.82Single6OS1TRV0266OS1-AT1-TRV026
12.82Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
12.82Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
12.82Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
12.82Single7P2L4YI7P2L-mGlu5-4YI
12.82Single7W41PD1762527W41-BB2-PD176252
12.82Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.82Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
12.82Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.82Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
12.82Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
12.82Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
12.82Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
12.82Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
12.82Consensusbombesin_offOrthosteric Ligandbb2_off
12.82Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
12.82Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
12.82Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
12.82Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
12.82Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
12.82Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
12.82Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.50Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
12.50Single4PY02MeSATP4PY0-P2Y12-2MeSATP
12.50Single5X33BIIL2605X33-BLT1-BIIL260
12.50Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
12.50Single6IIURamatroban6IIU-TP-Ramatroban
12.50Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
12.50Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
12.50Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
12.50Consensuschemokine_offOrthosteric Ligandcxcr_off
12.50Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
12.50Consensuscxcr_offOrthosteric Ligandcxcr4_off
12.50Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
12.50Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
12.50Consensusnts_onOrthosteric Ligandnts1_on
12.50Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
12.20Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
12.20Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
12.20Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
12.20Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
12.20Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
12.20Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.12Single6TQ9SB-4081246TQ9-OX1-SB-408124
12.12Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
12.12Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
12.12Single8A2OTheophylline8A2O-A2A-Theophylline-Na
12.12Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.12Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
11.90Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
11.90Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
11.90Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
11.86Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
11.76Single3OE8IT1t3OE8-CXCR4-IT1t
11.76Single4XNWMRS25004XNW-P2Y1-MRS2500
11.76Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
11.76Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
11.76Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
11.76Single6LI0GTPL98046LI0-GPR52-GTPL9804
11.76Single6ME5Agomelatine6ME5-MT1-Agomelatine
11.76Single6ME9Ramelteon6ME9-MT2-Ramelteon
11.76Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
11.76Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
11.76Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
11.76Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
11.76Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
11.76Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
11.76Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
11.76Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
11.76Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
11.76Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
11.63Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.63Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.63Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.43Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
11.43Single3PBLEticlopride3PBL-D3-Eticlopride
11.43Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
11.43Single5L7IVismodegib5L7I-SMO-Vismodegib
11.43Single6HLLCP999946HLL-NK1-CP99994
11.43Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
11.43Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
11.43Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
11.43Single7SRQLSD7SRQ-5-HT2B-LSD
11.43Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
11.43Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.43Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
11.43Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
11.43Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
11.43Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
11.43Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
11.43Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.43Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
11.43Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
11.43Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
11.43Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
11.43Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
11.43Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.43Consensusgo_proteinOrthosteric Ligandgo_chemokine
11.43Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
11.43Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
11.43Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
11.43Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
11.36Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.36Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
11.11Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
11.11Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
11.11Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
11.11Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
11.11Single3PWHZM2413853PWH-A2A-ZM241385
11.11Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
11.11Single5DHHSB-6121115DHH-NOP-SB-612111
11.11Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
11.11Single5ZKQABT-4915ZKQ-PAF-ABT-491
11.11Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
11.11Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
11.11Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
11.11Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
11.11Single7F8ULintitript7F8U-CCKA-Lintitript
11.11Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
11.11Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
11.11Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
11.11Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
11.11Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
11.11Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
11.11Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
11.11Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
11.11Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
11.11Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
11.11Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
11.11Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
11.11Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
11.11Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
11.11Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Consensusclass-f_offOrthosteric Ligandsmo_off
11.11Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
11.11Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
10.81Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
10.81Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
10.81Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
10.81Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
10.81Single5UVIZM2413855UVI-A2A-ZM241385
10.81Single6AQFZM2413856AQF-A2A-ZM241385
10.81Single6IQLL7458706IQL-D4-L745870
10.81Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
10.81Single6MH8ZM2413856MH8-A2A-ZM241385
10.81Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
10.81Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
10.81Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
10.81Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
10.81Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
10.81Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
10.81Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
10.81Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
10.81Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
10.81Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
10.81Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
10.81Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
10.81Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
10.81Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
10.81Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
10.81Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
10.81Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
10.81Consensussensory_offOrthosteric Ligandopsin_off
10.53Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
10.53Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
10.53Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
10.53Single6IIVDaltroban6IIV-TP-Daltroban
10.53Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
10.53Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
10.53Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
10.53Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
10.53Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
10.53Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
10.53Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
10.53Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
10.53Consensushcar_offOrthosteric Ligandsuccinate_off
10.53Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
10.53Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
10.53Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
10.26Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
10.26Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
10.26Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
10.26Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
10.26Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
10.26Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
10.26Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.26Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.26Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
10.26Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
10.26Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
10.26Consensusep_offOrthosteric Ligandep4_off
10.26Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single5TZR-5TZR-FFA1 (GPR40)-MK8666
10.00Single6E59L-7607356E59-NK1-L-760735
10.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
10.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
10.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
10.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
10.00Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
9.80Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
9.76Single6HLPNetupitant6HLP-NK1-Netupitant
9.76Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
9.76Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
9.76Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.76Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.76Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
9.76Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
9.76Consensusnts_offOrthosteric Ligandnts1_off
9.52Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
9.52Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
9.52Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
9.38Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
9.30Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
9.09Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
9.09Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
9.09Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
9.09Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
9.09Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8PWNTheophylline8PWN-A2A-Theophylline
9.09Consensusclass-c_onOther Ligandgabab_on mglu_on
9.09Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
8.89Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.82Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
8.82Single3RFMCaffeine3RFM-A2A-Caffeine
8.82Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
8.82Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
8.82Consensussensory_onOrthosteric Ligandopsin_on
8.57Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
8.57Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
8.57Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
8.57Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
8.57Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
8.57Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
8.57Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
8.57Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
8.57Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
8.57Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
8.33Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
8.33Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
8.33Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
8.33Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
8.33Single4O9RCyclopamine4O9R-SMO-Cyclopamine
8.33Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
8.33Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
8.33Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
8.33Single6TP4ACT-4622066TP4-OX1-ACT-462206
8.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
8.33Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
8.33Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
8.33Single7UL2SR486927UL2-NTS1-SR48692-Na
8.33Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
8.33Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
8.33Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
8.33Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
8.33Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
8.33Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
8.33Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.11Single4QINSAG1.54QIN-SMO-SAG1.5
8.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
8.11Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
8.11Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
8.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
8.11Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
8.11Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
8.11Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
8.11Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.11Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
8.11Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
8.11Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
8.11Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
7.89Single3REYPubChem 56973REY-A2A-PubChem 5697
7.89Single3RZECidoxepin3RZE-H1-Cidoxepin
7.89Single6DS0Ly2660976DS0-5-HT2B-Ly266097
7.89Single6FFIMMPEP6FFI-mGlu5-MMPEP
7.89Single6TPKRetosiban6TPK-OT-Retosiban
7.89Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
7.89Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
7.89Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
7.89Single7VODCariprazine7VOD-5-HT2A-Cariprazine
7.89Single7VV6C48/807VV6-MRGPRX2-C48/80
7.89Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
7.89Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
7.89Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
7.89Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.89Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
7.89Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
7.89Consensusgi_class-fOrthosteric Ligandgi_frizzled
7.89Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
7.89Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
7.89Consensusvasopressin-ot_offOrthosteric Ligandot_off
7.69Single6FFHFenobam6FFH-mGlu5-Fenobam
7.69Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
7.69Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
7.69Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
7.69Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
7.69Consensustachykinin_offOrthosteric Ligandnk1_off
7.50Single4NTJAZD12834NTJ-P2Y12-AZD1283
7.50Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
7.50Single6Z4SSR486926Z4S-NTS1-SR48692
7.50Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
7.50Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.32Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
7.32Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
7.32Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
7.14Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
7.14Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
6.98Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
6.98Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
6.98Consensuscyslt_offOrthosteric Ligandcyslt2_off
6.82Single6KNMJN241-96KNM-Apelin-JN241-9
6.52Single7SHEPI; PE7SHE-GPR158-PI; PE
6.25Single8HS2Fab0468HS2-GPR20-Fab046
6.06Single5MZPCaffeine5MZP-A2A-Caffeine-Na
6.06Single6W25Ca6W25-MC4-SHU9119-Ca
6.06Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
5.88Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
5.88Single7WC4Serotonin7WC4-5-HT2A-Serotonin
5.88Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
5.88Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
5.71Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.71Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.71Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
5.71Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
5.56Single3UZAGTPL92363UZA-A2A-GTPL9236
5.56Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.56Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
5.56Single7WC5Psilocin7WC5-5-HT2A-Psilocin
5.56Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.41Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
5.41Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
5.41Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
5.13Single6ZINSR486926ZIN-NTS1-SR48692
5.13Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.26Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.23Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
3.23Single6D35Cholesterol6D35-SMO-Cholesterol
3.23Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.23Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.23Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
3.23Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
3.23Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
3.23Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.23Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.23Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
3.23Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
3.23Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
3.23Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.23Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.23Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.23Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.23Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
3.23Single7DTTCa7DTT-CaS-Ca-Ca
3.23Single7DTTCa7DTT-CaS-Ca-Ca
3.23Single7DTUTryptophan7DTU-CaS-Tryptophan
3.23Single7DTUTryptophan7DTU-CaS-Tryptophan
3.23Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.23Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.23Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.23Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.23Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.23Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.23Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.23Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.23Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.23Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.23Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
3.23Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
3.23Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
3.23Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.23Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.23Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.23Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.23Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.23Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.23Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
3.23Single7FIIhCG7FII-LH-hCG-6fuf
3.23Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
3.23Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
3.23Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.23Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.23Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.23Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.23Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.23Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.23Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.23Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.23Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.23Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.23Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
3.23Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
3.23Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.23Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.23Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.23Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.23Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.23Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.23Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.23Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.23Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
3.23Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.23Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.23Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.23Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.23Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.23Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.23Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
3.23Single7XW7K1-707XW7-TSH-K1-70
3.23Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.23Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.23Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.23Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.23Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.23Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.23Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.23Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.23Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.23Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.23Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.23Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.23Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
3.23Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.23Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.23Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.23Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.23Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
3.23Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
3.23Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.23Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.23Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.23Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.23Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.23Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.23Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.23Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.23Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.23Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
3.23Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
3.23Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
3.23Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
3.23Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.23Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.23Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.23Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.23Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.23Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.23Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.23Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.23Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.23Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.23Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.23Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.23Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.23Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.23Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.23Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.23Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
3.23Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
3.23Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
3.23Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
3.23Consensusclass-c_offOther Ligandgabab_off mglu_off
3.23Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
3.23Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
3.23Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
3.23Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
3.23Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
3.23Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
3.23Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
3.23Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
3.23Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.23Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.23Consensusgphr_onOrthosteric Ligandlh_on tsh_on
3.23Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
3.23Consensusgs_proteinOrthosteric Ligandgs_gphr
3.23Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
3.23Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
3.23Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
3.23Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
3.23Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.23Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.23Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
3.23Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
3.23Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.23Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.23Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
3.23Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
3.23Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
3.23Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
3.23Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
3.23Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
3.23Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
3.23Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
3.23Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
3.12Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.12Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.12Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.12Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.12Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.12Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.12Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.12Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.12Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
3.12Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
3.03Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
3.03Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
2.94Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
2.94Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
2.94Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
2.94Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
2.94Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
2.94Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
2.94Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
2.94Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
2.94Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
2.86Single5L7DCholesterol5L7D-SMO-Cholesterol
2.86Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
2.86Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
2.86Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
2.78Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
2.78Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
2.70Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
2.70Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
2.70Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
2.70Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
2.70Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
2.63Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.63Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
2.63Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
2.63Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
2.56Single4K5YCP-3763954K5Y-CRF1-CP-376395
2.56Single4XNVBPTU4XNV-P2Y1-BPTU
2.56Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
2.56Single8HNNSCH5467388HNN-CXCR3-SCH546738
2.56Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
2.56Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
2.50Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.50Single8IYXYL-3658IYX-GPR34-YL-365
2.44Single4Z9GCP-3763954Z9G-CRF1-CP-376395
2.44Single8GTIBMK-C2058GTI-CRF1-BMK-C205
2.38Single8GTGBMK-I1528GTG-CRF1-BMK-I152
2.27Single7SHEPI; PE7SHE-GPR158-PI; PE
2.27Single8GTMBMK-C2038GTM-CRF1-BMK-C203
2.22Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
8FLQ 8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
7Y35 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
7Y36 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
7F16 7F16-PTH2-TIP39-Gs/&β;1/&γ;2
7VVM 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
8FLU 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
6NBF 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
Net Summary
Imin 3.02429
Number of Linked Nodes 891
Number of Links 1125
Number of Hubs 189
Number of Links mediated by Hubs 725
Number of Communities 23
Number of Nodes involved in Communities 260
Number of Links involved in Communities 412
Path Summary
Number Of Nodes in MetaPath 108
Number Of Links MetaPath 107
Number of Shortest Paths 2129019
Length Of Smallest Path 3
Average Path Length 31.6663
Length of Longest Path 58
Minimum Path Strength 0.212857
Average Path Strength 6.8552
Maximum Path Strength 66.2757
Minimum Path Correlation 0.7
Average Path Correlation 0.987954
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.88679
Average % Of Corr. Nodes 49.23
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.3814
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gs_class-b1gs_glucagon
gs_vip-pacap
gs_pth
gs_calcitonin
gs_crf



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