Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1NT 45.7731025
21x38 11.09424
31x39 3.506527
41x42 7.71427
51x49 3.14754108
61x50 5.054109
71x55 7.375403
81x56 3.1225407
9I1x50 6.275407
102x39 3.7625498
112x42 5.01407
122x45 5.876529
132x46 4.4825429
142x57 7.038527
15E1x50 6.948528
163x30 3.895626
173x37 8.595426
183x38 4.30667627
193x41 7.86833625
203x50 5.462529
213x51 6.1385117
223x54 2.675408
23I2x54 6.3075495
24I2x56 5.475497
254x48 3.85423
264x49 3.676527
274x50 4.562529
28E2 16.68482924
29E2x50 4.8775429
30E2x52 4.36833624
315x39 11.7075426
325x42 4.73333624
335x43 5.76333625
345x461 5.99857726
355x47 4.705428
365x51 4.9975427
375x57 3.37754118
385x58 5.07529
396x26 6.45465
406x40 7.164528
416x44 5.9675429
426x48 8.738528
436x51 8.798526
44E3 7.72833622
457x48 4.285625
467x52 3.3475428
477x53 6.70875829
487x54 5.00754107
498x50 8.1245108
50Lig 6.38222920
51G.HN.43 3.525409
52G.S1.02 4.02754135
53G.S1.05 5.6725419
54G.S1.07 3.338519
55G.s1h1.01 2.194519
56G.s1h1.05 2.555419
57G.H1.01 5.944519
58G.S2.01 4.3125418
59G.S2.04 2.555417
60G.S2.06 7.568518
61G.S3.03 4.1825407
62G.S3.04 8.316517
63G.S3.06 8.22833616
64G.s3h2.03 5.004519
65G.H2.06 5.81857719
66G.H2.07 5.67667619
67G.H2.10 4.855417
68G.h2s4.01 5.965619
69G.S4.02 4.468518
70G.S4.04 5.6519
71G.s4h3.01 9.3975417
72G.H3.08 5.2875419
73G.H3.09 5.56833619
74G.H3.13 3.82405
75G.H3.17 6.755614
76G.H3.18 4.42333619
77G.S5.01 4.8625468
78G.S5.02 3.925416
79G.S5.03 3.3025409
80G.S5.05 3.75333669
81G.S5.06 3.745618
82G.HG.01 6.798515
83G.HG.08 5.0375417
84G.HG.14 4.5325405
85G.H4.05 5.4525404
86G.H4.10 14.55417
87G.H4.15 6.304518
88G.h4s6.10 3.882564
89G.h4s6.12 7.608564
90G.S6.01 5.2975415
91G.S6.02 6.47714768
92G.S6.05 6.055415
93G.s6h5.01 5.67569
94G.H5.08 7.3854148
95G.H5.13 8.6725467
96G.H5.14 4.8625467
97G.H5.17 6.27857766
98G.H5.23 3.3875404
99G.H5.26 4.4875465
100b.1x11 2.7175408
101b.1x19 5.312516
102b.h2x1 4.8675405
103b.lhb1x3 4.985412
104b.lhb1x6 5.588513
105b.b1x3 4.175437
106b.b1x4 4.82537
107b.l1x3 5.26571739
108b.l1x7 4.426539
109b.b2x1 7.418518
110b.b2x5 5.89429737
111b.b3x2 5.0275435
112b.b3x3 4.058578
113b.l3x1 7.9575419
114b.l3x2 8.775409
115b.b4x3 5.104577
116b.b4x4 9.135438
117b.b4x5 3.035677
118b.b4x6 9.99714739
119b.b4x7 6.77254158
120b.b5x3 4.77833639
121b.b5x5 5.6575475
122b.b5x7 5.372577
123b.l5x5 7.41719
124b.b6x1 3.075409
125b.b6x5 4.17375876
126b.l6x3 4.21406
127b.b7x2 3.204578
128b.b7x3 2.3925459
129b.b7x4 4.25408
130b.l7x2 3.56419
131b.l7x4 4.925409
132b.b8x3 4.185456
133b.b8x4 5.138576
134b.l8x1 5.2675475
135b.l9x3 4.845459
136b.l9x6 4.56333618
137b.b10x2 3.815446
138b.b10x3 4.275458
139b.b10x5 4559
140b.l10x1 4.14443
141b.b11x2 4.5375457
142b.b11x3 3.725445
143b.b11x4 4.48659
144b.b11x5 3.64446
145b.b11x6 5.61409
146b.b12x3 3.872548
147b.b12x5 3.448546
148b.b12x6 12.1475458
149b.l12x1 3.926556
150b.b13x7 6.60333647
151b.l13x3 6.46429749
152b.l13x6 4.59167619
153b.l13x7 4.102549
154b.b14x1 5.2675418
155b.b14x3 3.404545
156b.b15x1 6.598549
157b.b15x3 3.974549
158b.l15x1 6.69417
159b.b16x4 10.362546
160b.b16x6 8.21748
161b.b17x5 9.315417
162b.b17x7 5.74618
163b.l17x3 8.06857719
164b.b18x3 4.7425408
165b.b18x5 3.35615
166b.l18x1 7.72816
167b.l18x3 9.45415
168b.b19x2 5.50429716
169b.b19x4 4.732518
170b.b19x5 2.3415
171b.b19x6 7.3425419
172b.l19x2 9.22419
173b.b20x2 4.964516
174b.b20x3 2.288518
175b.b20x4 7.45667618
176b.b20x5 5.22417
177b.b20x6 3.78333616
178b.l20x2 10.455419
179b.b21x1 11.775417
180b.b21x2 6.4775406
181b.b21x5 5.634514
182b.b21x7 5.24857715
183b.l21x2 7.6525414
184b.l21x5 7.125414
185b.b22x3 2.06416
186b.b22x5 6.766517
187b.l22x4 3.56419
188b.l22x5 6.45125819
189b.b23x2 4.645416
190b.b23x6 9.912517
191b.b24x4 9.7325416
192b.b24x6 5.895618
193b.b24x7 7.865419
194b.l24x2 5.44833616
195b.l24x3 5.0325415
196b.b25x3 4.585615
197b.b25x6 4.0375413
198b.l25x3 7.785689
199b.l25x6 11.856518
200b.b26x2 3.3825437
201b.b26x3 3.718536
202b.b26x4 3.3575435
203b.l27x1 7.6925437
204b.b27x3 4.6275408
205b.l28x1 10.4986719
206b.l28x2 7.128589
207b.b28x3 3.744537
208b.b28x4 6.576586
209b.b28x5 3.1275435
210b.b28x6 8.972589
211b.b28x7 5.1125439
212g.h2x11 5.4275449
213g.h2x12 4.3925408
214g.l2x3 6.026518
215g.h3x1 5.945406
216g.h3x3 3.64833615
217g.h3x4 4.6025405.5
218g.h3x8 6.26414
219g.h3x12 3.215416
220g.l3x4 6.816509
221g.ctx2 3.6875436
222g.ctx9 4.41143737
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1E2 NT 10.166259.09YesYes245
2E2 Lig 17.12052.34YesYes240
3b.l25x5 b.l28x2 10.89852.69NoYes079
4b.l25x5 b.l28x1 11.13877.91NoYes079
5G.H2.09 b.l28x1 10.65466.35NoYes189
6G.H2.09 G.H3.17 10.688513.75NoYes184
7G.H3.17 G.H3.18 43.40422YesYes149
8G.H3.18 G.S4.02 43.86186.28YesYes198
9G.S1.07 G.S4.02 39.08752.85YesYes198
10G.S1.07 G.s1h1.01 1001.71YesYes199
11G.H1.01 G.s1h1.01 86.9263.49YesYes199
12G.H1.01 G.S1.06 86.84025.64YesNo199
13G.S1.06 G.S3.05 86.80555.65NoNo197
14G.S2.06 G.S3.05 86.40727.46YesNo187
15G.S2.06 G.S3.03 86.27626.43YesYes087
16G.S1.02 G.S3.03 85.685.24YesYes057
17G.H5.15 G.S1.02 88.73861.54NoYes085
18G.H5.15 G.H5.18 88.66294.1NoNo084
19G.H5.18 G.H5.19 88.587214.46NoNo048
20G.H5.19 G.H5.22 88.51132.69NoNo084
212x39 G.H5.22 88.43546.79YesNo084
222x39 3x49 62.37282.65YesNo988
232x42 3x49 62.552210.93YesNo078
242x42 3x45 62.37523.07YesNo077
253x45 4x48 30.48612.62NoYes073
263x41 4x48 20.73244.01YesYes253
273x37 3x41 18.90567.63YesYes265
283x37 Lig 18.47843.52YesYes260
29G.h2s4.02 b.l28x1 10.66552.18NoYes079
30G.H3.17 G.h2s4.02 10.697414.17YesNo047
31b.l25x6 b.l28x1 11.162426.99YesYes189
32G.H3.17 b.l25x6 22.3446YesYes148
33b.b2x1 b.l28x1 11.37867.72YesYes189
34G.H2.10 b.b2x1 15.32024.03YesYes178
35G.H2.10 G.h2s4.01 15.31095.59YesYes179
36G.S1.05 G.h2s4.01 38.19119.74YesYes199
37G.S1.05 G.S1.07 37.85572.77YesYes199
383x45 4x49 31.80073.17NoYes077
393x41 4x49 20.76032.43YesYes257
403x41 5x461 18.87368.46YesYes256
415x42 5x461 25.13634.36YesYes246
425x42 E2 24.14188.68YesYes244
433x38 4x49 10.2593.04YesYes277
443x50 G.H5.23 21.74966.96YesYes094
453x50 7x53 16.12032.06YesYes299
46G.H5.06 G.S6.02 11.2832.06NoYes648
47b.b26x2 b.l1x7 10.23463.27YesYes379
48b.b26x1 b.b26x2 31.74013.44NoYes097
49b.b26x1 b.l28x1 31.95824.94NoYes099
50G.H3.08 G.S1.07 16.71216.92YesYes199
51G.S5.07 G.s1h1.06 14.13125.09NoNo099
52G.S5.07 G.s6h5.01 13.74835.85NoYes099
53G.H2.07 G.s3h2.03 24.30627.67YesYes199
54G.H2.04 G.H2.07 19.28618NoYes099
55G.H2.04 G.H3.08 19.26537.29NoYes099
56G.H2.07 G.h2s4.01 16.9644.01YesYes199
57G.H2.07 b.l7x2 11.81442.28YesYes199
58G.s3h2.03 b.l9x6 23.63493.38YesYes198
59G.H2.06 b.l9x6 10.69693.58YesYes198
60G.H2.06 b.l19x1 10.35014.15YesNo199
61G.HG.04 G.HG.08 10.862210.05NoYes197
62b.l17x5 b.l19x1 15.03612.94NoNo169
63b.b19x6 b.l17x5 13.33643.26YesNo196
64b.b19x6 b.l17x3 12.030713.95YesYes199
65b.b26x2 b.b2x3 20.78054.86YesNo376
66b.b2x3 b.b2x5 19.06384.65NoYes367
67b.b2x5 b.l27x1 10.149812.13YesYes377
68b.b6x1 b.l7x2 17.55452.83YesYes099
69b.b6x1 b.l7x1 23.48083.49YesNo099
70b.b7x5 b.l7x1 23.25592.11NoNo099
71b.b7x4 b.b7x5 14.32193.92YesNo089
72b.b4x3 b.b7x4 11.21017.94YesYes078
732x39 G.H5.23 24.3523.17YesYes084
74G.s1h1.05 G.s1h1.06 14.19561.86YesNo099
75G.s1h1.01 G.s1h1.05 14.26761.86YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
NTNT175.242YesYes5522
E2NT59.092YesYes4512
1x32NT9.242NoYes5522
1x32E29.012NoYes5421
1x35E22.830NoYes5421
1x392x574.982YesYes7722
1x392x603.012YesNo7722
1x397x424.322YesNo7721
2x533x363.490NoNo7712
2x537x464.830NoNo7912
2x53Lig1.880NoYes7010
2x577x429.932YesNo7721
2x577x462.772YesNo7922
2x60E24.892NoYes7421
2x63E25.072NoYes5421
2x64E23.442NoYes5421
3x25E21.882NoYes9421
3x264x612.752NoNo7522
3x26E28.142NoYes7421
3x29E28.692NoYes5421
3x304x616.092YesNo6522
3x30E24.132YesYes6421
3x32Lig3.140NoYes5010
3x33E24.992NoYes4421
3x33E2x524.562NoYes4421
3x373x417.632YesYes6512
3x374x5612.152YesNo6512
3x375x46111.082YesYes6612
3x37Lig3.522YesYes6010
3x406x444.872NoYes7922
3x406x4820.52NoYes7821
3x415x4618.462YesYes5622
4x565x433.242NoYes5521
4x565x4617.372NoYes5622
4x594x605.842NoNo7522
4x59E25.42NoYes7421
4x60E221.642NoYes5421
4x60E2x525.082NoYes5421
4x61E23.522NoYes5421
5x35E22.260NoYes3421
5x39E225.242YesYes6421
5x42E28.682YesYes4421
5x36E223.52NoYes4421
E2E2121.122YesYes4411
E2E2x524.842YesYes4411
E2E2x516.552YesNo4512
6x51E26.212YesYes6411
7x34E24.142NoYes4421
7x35E26.342NoYes4421
5x39E2x525.022YesYes6421
5x43E2x522.922YesYes5411
E2x52Lig3.792YesYes4010
6x54E25.050NoYes5421
E2Lig2.342YesYes4010
6x58E22.422NoYes4421
5x395x424.132YesYes6422
5x395x4312.442YesYes6521
5x425x433.592YesYes4521
5x425x4614.362YesYes4622
5x435x4613.942YesYes5612
5x43Lig8.452YesYes5010
6x446x489.022YesYes9821
6x476x486.532NoYes8821
6x486x513.862YesYes8611
6x48Lig3.782YesYes8010
6x517x378.342YesNo6612
6x517x415.342YesNo6812
6x51Lig20.242YesYes6010
6x587x342.922NoNo4422
7x42Lig10.32NoYes7010
6x55E21.330NoYes5421

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
100.00Consensusgt_class-aOrthosteric Ligandgt_opsin
100.00Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
77.78Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
66.67Consensussensory_onOrthosteric Ligandopsin_on
63.64Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
63.64Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
60.00Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
60.00Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
60.00Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
60.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
60.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
58.33Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
55.56Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
55.56Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
54.55Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
53.85Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
53.33Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
53.33Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
53.33Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
50.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
50.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
50.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
50.00Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
50.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
50.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
46.67Single2YDVNECA2YDV-A2A-NECA
46.67Single4UHRCGS216804UHR-A2A-CGS21680
46.67Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
46.67Single5G53NECA5G53-A2A-NECA-Gs
46.67Single5V54Methiothepin5V54-5-HT1B-Methiothepin
46.67Single6J21Aprepitant6J21-NK1-Aprepitant
46.67Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
46.67Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
46.67Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
46.67Consensus5ht1_offOrthosteric Ligand5ht1b_off
46.67Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
46.67Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
46.67Consensusa2_onOrthosteric Liganda2a_on a2b_on
46.15Single2YDOAdenosine2YDO-A2A-Adenosine
46.15Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
46.15Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
46.15Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
46.15Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
46.15Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
46.15Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
46.15Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
46.15Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
46.15Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Consensussensory_offOrthosteric Ligandopsin_off
45.45Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
45.45Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
45.45Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
45.45Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
44.44Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
44.44Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
44.44Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
43.75Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
43.75Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
42.86Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
42.86Single3NY8ICI 118-5513NY8-β2-ICI 118-551
42.86Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
42.86Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
42.86Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
42.86Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
42.86Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
42.86Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
42.86Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
42.86Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
42.86Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
42.86Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
42.86Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
42.86Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
42.86Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
42.86Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
42.86Consensusadenosine_onOrthosteric Liganda1_on a2_on
42.86Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
42.86Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
42.86Consensusnucleotide_onOrthosteric Ligandadenosine_on
42.86Consensustar_onOrthosteric Ligandta1_on
42.11Single6HLOAprepitant6HLO-NK1-Aprepitant
41.67Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
41.67Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
41.67Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
41.67Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
41.67Single3PBLEticlopride3PBL-D3-Eticlopride
41.67Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
41.67Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
41.67Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
41.67Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
41.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
41.67Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
41.18Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
41.18Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
41.18Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
41.18Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
41.18Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
41.18Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
41.18Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
40.00Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
40.00Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
40.00Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
40.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
40.00Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
40.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
40.00Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
40.00Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
40.00Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
40.00Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
40.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
40.00Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
40.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
38.89Single3NY9PubChem 9131033NY9-β2-PubChem 913103
38.89Single4UG2CGS216804UG2-A2A-CGS21680
38.46Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
38.46Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
38.46Single6KUXRS-799486KUX-α2a-RS-79948
38.46Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
38.46Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
38.46Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
38.46Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
38.46Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
38.46Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
38.46Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
38.46Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
38.46Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
38.46Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
38.46Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
38.46Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Single8GGVEpinephrine8GGV-β2-Epinephrine
38.46Single8GGWEpinephrine8GGW-β2-Epinephrine
38.46Single8GGXEpinephrine8GGX-β2-Epinephrine
38.46Single8GH0Epinephrine8GH0-β2-Epinephrine
38.46Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
38.46Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
38.46Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
38.46Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
38.46Consensusalpha1_onOrthosteric Ligandalpha1a_on
38.46Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
38.46Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
38.46Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
38.10Single7C61Ergotamine7C61-5-HT1B-Ergotamine
37.50Single4U15Tiotropium4U15-M3-Tiotropium
37.50Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
37.50Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
37.50Single5X93K-87945X93-ETB-K-8794
37.50Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
37.50Single6OL9Tiotropium6OL9-M5-Tiotropium
37.50Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
37.50Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
37.50Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
37.50Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
37.50Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
37.50Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
37.50Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
37.50Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
37.50Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
37.50Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
37.50Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
37.50Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
37.50Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
37.50Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
37.50Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
36.84Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
36.84Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
36.84Consensussst_onOrthosteric Ligandsst2_on sst4_on
36.36Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
36.36Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
36.36Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
36.36Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
35.71Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
35.71Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
35.71Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
35.71Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
35.71Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
35.71Single6A94Zotepine6A94-5-HT2A-Zotepine
35.71Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
35.71Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
35.71Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
35.71Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
35.71Single6PS4ICI 118-5516PS4-β2-ICI 118-551
35.71Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
35.71Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
35.71Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
35.71Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
35.71Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
35.71Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
35.71Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.71Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
35.71Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
35.71Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
35.71Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
35.71Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
35.71Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
35.71Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
35.71Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8GGIEpinephrine8GGI-β2-Epinephrine
35.71Single8GGQEpinephrine8GGQ-β2-Epinephrine
35.71Single8GGTEpinephrine8GGT-β2-Epinephrine
35.71Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
35.71Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
35.71Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.71Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.71Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
35.71Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
35.71Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
35.29Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
35.29Single4AMIBucindolol4AMI-β1-Bucindolol
35.29Single5CXVTiotropium5CXV-M1-Tiotropium
35.29Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
35.29Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
35.29Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
35.29Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
35.29Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
35.29Single7K15MKD0467K15-BLT1-MKD046-Na
35.29Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
35.29Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
35.29Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
35.29Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
35.29Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
35.29Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
35.29Consensusblt_offOrthosteric Ligandblt1_off
35.29Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
35.29Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
35.29Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
35.29Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
33.33Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
33.33Single2Y01Dobutamine2Y01-β1-Dobutamine
33.33Single2Y04Salbutamol2Y04-β1-Salbutamol
33.33Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
33.33Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
33.33Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
33.33Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
33.33Single4EJ4Naltrindole4EJ4-δ-Naltrindole
33.33Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
33.33Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
33.33Single5TGZAM65385TGZ-CB1-AM6538
33.33Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
33.33Single5WF5UK-4320975WF5-A2A-UK-432097
33.33Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
33.33Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
33.33Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
33.33Single6H7MSalbutamol6H7M-β1-Salbutamol
33.33Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
33.33Single6ME5Agomelatine6ME5-MT1-Agomelatine
33.33Single6ME9Ramelteon6ME9-MT2-Ramelteon
33.33Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
33.33Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
33.33Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
33.33Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
33.33Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
33.33Single7BU7BI1671077BU7-β1-BI167107
33.33Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
33.33Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
33.33Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
33.33Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
33.33Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
33.33Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
33.33Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
33.33Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
33.33Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
33.33Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
33.33Single7UL4Alvimopan7UL4-μ-Alvimopan
33.33Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
33.33Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
33.33Single7WC7Lisuride7WC7-5-HT2A-Lisuride
33.33Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
33.33Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
33.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
33.33Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
33.33Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
33.33Single8CU6LJ-45178CU6-A2A-LJ-4517
33.33Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGJEpinephrine8GGJ-β2-Epinephrine
33.33Single8GGNEpinephrine8GGN-β2-Epinephrine
33.33Single8GGOEpinephrine8GGO-β2-Epinephrine
33.33Single8GGREpinephrine8GGR-β2-Epinephrine
33.33Single8GGUEpinephrine8GGU-β2-Epinephrine
33.33Single8GGZEpinephrine8GGZ-β2-Epinephrine
33.33Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
33.33Single8JJOAlprenolol8JJO-β2-Alprenolol
33.33Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
33.33Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
33.33Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
33.33Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8X64Desloratadine8X64-H1-Desloratadine
33.33Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
33.33Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
33.33Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
33.33Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
33.33Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
33.33Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
33.33Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
33.33Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
33.33Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
33.33Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
33.33Consensusendothelin_offOrthosteric Ligandetb_off
33.33Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
33.33Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
33.33Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
33.33Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
33.33Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
31.82Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
31.58Single5WF6UK-4320975WF6-A2A-UK-432097
31.58Single6PT3DPI-2876PT3-δ-DPI-287
31.58Single7SK9CCX6627SK9-ACKR3-CCX662
31.58Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
31.58Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
31.25Single2Y00Dobutamine2Y00-β1-Dobutamine
31.25Single2Y03Isoprenaline2Y03-β1-Isoprenaline
31.25Single5CGCHTL142425CGC-mGlu5-HTL14242
31.25Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
31.25Single5N2SPSB365N2S-A1-PSB36
31.25Single5WIUNemonapride5WIU-D4-Nemonapride
31.25Single5WIVNemonapride5WIV-D4-Nemonapride-Na
31.25Single5XPRBosentan5XPR-ETB-Bosentan
31.25Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
31.25Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
31.25Single6LUQHaloperidol6LUQ-D2-Haloperidol
31.25Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
31.25Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
31.25Single6PS6Timolol6PS6-β2-Timolol
31.25Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
31.25Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
31.25Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
31.25Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
31.25Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
31.25Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
31.25Single7SINNPS-21437SIN-CaS-NPS-2143
31.25Single7SINNPS-21437SIN-CaS-NPS-2143
31.25Single7XKAEpinephrine7XKA-β2-Epinephrine
31.25Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
31.25Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
31.25Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
31.25Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
31.25Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
31.25Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
31.25Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
31.25Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
31.25Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
31.25Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
31.25Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
31.25Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
31.25Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
31.25Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
31.25Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
31.25Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.25Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.25Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
30.77Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
30.77Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
30.77Single6HLLCP999946HLL-NK1-CP99994
30.77Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
30.77Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
30.77Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
30.77Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
30.77Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
30.77Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
30.77Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
30.77Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
30.77Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
30.77Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
30.77Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
30.77Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.77Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.77Single8GGSEpinephrine8GGS-β2-Epinephrine
30.77Single8GGYEpinephrine8GGY-β2-Epinephrine
30.77Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
30.77Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
30.77Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
30.77Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single8K5BNiacin8K5B-HCA2-Niacin
30.77Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.77Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
30.77Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
30.77Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
30.77Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
30.43Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
30.00Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
30.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
30.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
30.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
30.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
30.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
30.00Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
30.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
30.00Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
29.41Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
29.41Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
29.41Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
29.41Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
29.41Single6H7JIsoprenaline6H7J-β1-Isoprenaline
29.41Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
29.41Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
29.41Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
29.41Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
29.41Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
29.41Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
29.41Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
29.41Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
29.41Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
29.41Single7W41PD1762527W41-BB2-PD176252
29.41Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
29.41Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
29.41Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
29.41Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
29.41Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
29.41Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
29.41Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
29.41Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
29.41Consensusadenosine_offOrthosteric Liganda1_off a2_off
29.41Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
29.41Consensusbombesin_offOrthosteric Ligandbb2_off
29.41Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
29.41Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
29.41Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
29.41Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
29.41Consensushistamine_offOrthosteric Ligandh1_off
29.41Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
29.41Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
29.41Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
29.41Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
28.57Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
28.57Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
28.57Single3QAKUK-4320973QAK-A2A-UK-432097
28.57Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
28.57Single5WS3EMPA5WS3-OX2-EMPA
28.57Single6B73PubChem 1319551386B73-κ-PubChem 131955138
28.57Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
28.57Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
28.57Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
28.57Single6ME2Ramelteon6ME2-MT1-Ramelteon
28.57Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
28.57Single6TODEMPA6TOD-OX1-EMPA-Na
28.57Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
28.57Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
28.57Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
28.57Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
28.57Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
28.57Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
28.57Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
28.57Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
28.57Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
28.57Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
28.57Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
28.57Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
28.57Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
28.57Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
28.57Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
28.57Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8GNGIstradefylline8GNG-A2A-Istradefylline
28.57Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
28.57Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
28.57Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
28.57Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8IWESpermidine8IWE-TAAR9-Spermidine
28.57Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
28.57Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
28.57Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
28.57Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
28.57Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
28.57Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
28.57Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
28.57Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
28.57Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
28.57Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
27.78Single4LDEBI1671074LDE-β2-BI167107
27.78Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.78Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
27.78Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
27.78Single6HLPNetupitant6HLP-NK1-Netupitant
27.78Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
27.78Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
27.78Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
27.78Single6ZG4HTL00099366ZG4-M1-HTL0009936
27.78Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
27.78Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
27.78Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.78Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.78Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
27.78Single7YITNalfurafine7YIT-κ-Nalfurafine
27.78Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
27.78Single8JJ8Formoterol8JJ8-β2-Formoterol
27.78Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
27.78Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
27.78Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
27.78Consensusgi_class-fOther Ligandgi_frizzled
27.78Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
27.78Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
27.78Consensusgs_steroidOrthosteric Ligandgs_bileacid
27.78Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
27.78Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
27.27Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
27.27Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
27.27Single8PWNTheophylline8PWN-A2A-Theophylline
27.27Consensusangiotensin_onOrthosteric Ligandat1_on
27.27Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
27.27Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
27.27Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
27.27Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
27.27Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
26.67Single3RZECidoxepin3RZE-H1-Cidoxepin
26.67Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
26.67Single4ZJCSB-6740424ZJC-OX1-SB-674042
26.67Single5IU7Q274563465IU7-A2A-Q27456346-Na
26.67Single5JTBZM2413855JTB-A2A-ZM241385
26.67Single5K2BZM2413855K2B-A2A-ZM241385-Na
26.67Single5UVIZM2413855UVI-A2A-ZM241385
26.67Single6AQFZM2413856AQF-A2A-ZM241385
26.67Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
26.67Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
26.67Single6MH8ZM2413856MH8-A2A-ZM241385
26.67Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
26.67Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
26.67Single6TPGEMPA6TPG-OX2-EMPA
26.67Single6TPNHTL66416TPN-OX2-HTL6641
26.67Single6V9SGTPL114036V9S-OX1-GTPL11403
26.67Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
26.67Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
26.67Single7AROLUF58337ARO-A2A-LUF5833-Na
26.67Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
26.67Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
26.67Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
26.67Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
26.67Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
26.67Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67Single7T32ZM2413857T32-A2A-ZM241385
26.67Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
26.67Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
26.67Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
26.67Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
26.67Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
26.67Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Single8GGKEpinephrine8GGK-β2-Epinephrine
26.67Single8GGLEpinephrine8GGL-β2-Epinephrine
26.67Single8GGMEpinephrine8GGM-β2-Epinephrine
26.67Single8GGPEpinephrine8GGP-β2-Epinephrine
26.67Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
26.67Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
26.67Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
26.67Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
26.67Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
26.67Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
26.67Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
26.67Single8K5CAcipimox8K5C-HCA2-Acipimox
26.67Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67Consensus5ht5_onOrthosteric Ligand5ht5a_on
26.67Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
26.67Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
26.67Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
26.67Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
26.67Consensushca_onOrthosteric Ligandhca2_on hca3_on
26.67Consensushcar_onOrthosteric Ligandhca_on
26.67Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
26.67Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
26.32Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.32Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
26.32Single5CGDHTL142425CGD-mGlu5-HTL14242
26.32Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
26.32Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
26.32Single6H7LDobutamine6H7L-β1-Dobutamine
26.32Single6IBLArformoterol6IBL-β1-Arformoterol
26.32Single7EZCUKA7EZC-A2A-UKA
26.32Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
26.32Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
26.32Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
26.32Single7UM4AS26747237UM4-5-HT5A-AS2674723
26.32Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
26.32Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
26.32Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
26.32Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
26.32Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
26.32Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
26.32Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
26.32Consensussteroid_onOrthosteric Ligandbileacid_on
26.09Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
26.09Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
26.09Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
26.09Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
26.09Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
26.09Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.93Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.93Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single2Y02Carmoterol2Y02-β1-Carmoterol
25.00Single3EMLZM2413853EML-A2A-ZM241385
25.00Single4EIYZM2413854EIY-A2A-ZM241385-Na
25.00Single4MQSIperoxo4MQS-M2-Iperoxo
25.00Single4U14Tiotropium4U14-M3-Tiotropium
25.00Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
25.00Single5EE7MK08935EE7-Glucagon-MK0893
25.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
25.00Single5K2AZM2413855K2A-A2A-ZM241385-Na
25.00Single5OLGZM2413855OLG-A2A-ZM241385-Na
25.00Single5UENDU1725UEN-A1-DU172
25.00Single5VRAZM2413855VRA-A2A-ZM241385-Na
25.00Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
25.00Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
25.00Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
25.00Single5ZTYAM102575ZTY-CB2-AM10257
25.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
25.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
25.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
25.00Single6IIVDaltroban6IIV-TP-Daltroban
25.00Single6PS1Timolol6PS1-β2-Timolol
25.00Single6S0LZM2413856S0L-A2A-ZM241385
25.00Single6TOTLemborexant6TOT-OX1-Lemborexant
25.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
25.00Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
25.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
25.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
25.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.00Single7PYRPSB-21157PYR-A2A-PSB-2115
25.00Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
25.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
25.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
25.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
25.00Single7XN9L-054,5227XN9-SST2-L-054,522
25.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
25.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
25.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
25.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
25.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
25.00Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
25.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
25.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
25.00Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
25.00Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
25.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
25.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
25.00Single8X5YAstemizole8X5Y-H1-Astemizole
25.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
25.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
25.00Consensusa2_offOrthosteric Liganda2a_off
25.00Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
25.00Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
25.00Consensusblt_onOrthosteric Ligandblt1_on
25.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
25.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
25.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
25.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Consensusgi_hcarOrthosteric Ligandgi_hca
25.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
25.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
25.00Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
25.00Consensushistamine_onOrthosteric Ligandh1_on h4_on
25.00Consensusleuko_onOrthosteric Ligandblt_on
25.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
25.00Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
25.00Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
24.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
24.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single7F8XNN90567F8X-CCKA-NN9056
23.81Single7QA8Peptide7QA8-STE2-Peptide
23.81Single7QA8Peptide7QA8-STE2-Peptide
23.81Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
23.81Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
23.81Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
23.81Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
23.81Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.81Consensusclass-d_offOrthosteric Ligandste2_off
23.81Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
23.81Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
23.53Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
23.53Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
23.53Single5C1MBU725C1M-μ-BU72
23.53Single5IUAQ274563485IUA-A2A-Q27456348-Na
23.53Single5NM2ZM2413855NM2-A2A-ZM241385-Na
23.53Single5TVNLSD5TVN-5-HT2B-LSD
23.53Single5WQCEMPA5WQC-OX2-EMPA
23.53Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
23.53Single6D26Fevipiprant6D26-DP2-Fevipiprant
23.53Single6E67BI1671076E67-β2-BI167107-Gs (fused)
23.53Single6LPLZM2413856LPL-A2A-ZM241385-Na
23.53Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
23.53Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
23.53Single6S0QZM2413856S0Q-A2A-ZM241385
23.53Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
23.53Single6TP6Filorexant6TP6-OX1-Filorexant
23.53Single6WQAZM2413856WQA-A2A-ZM241385-Na
23.53Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
23.53Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
23.53Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
23.53Single7RM5ZM2413857RM5-A2A-ZM241385-Na
23.53Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
23.53Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
23.53Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
23.53Single7WC6LSD7WC6-5-HT2A-LSD
23.53Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
23.53Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
23.53Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
23.53Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
23.53Single8FYNZM2413858FYN-A2A-ZM241385-Na
23.53Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
23.53Single8GNEKW-63568GNE-A2A-KW-6356-Na
23.53Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
23.53Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
23.53Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
23.53Single8QOTNanobody E8QOT-μ-Nanobody E
23.53Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
23.53Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
23.53Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
23.53Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
23.53Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
23.53Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
23.08Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
23.08Single3UZAGTPL92363UZA-A2A-GTPL9236
23.08Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
23.08Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
23.08Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
23.08Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
23.08Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
22.73Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
22.73Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
22.73Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
22.22Single3P0GBI1671073P0G-β2-BI167107
22.22Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
22.22Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
22.22Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
22.22Single4DJHJDTic4DJH-κ-JDTic
22.22Single4RWADIPP-NH24RWA-δ-DIPP-NH2
22.22Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
22.22Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
22.22Single6J20Aprepitant6J20-NK1-Aprepitant
22.22Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
22.22Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
22.22Single6TQ7SB-3348676TQ7-OX1-SB-334867
22.22Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
22.22Single6WGTLSD6WGT-5-HT2A-LSD
22.22Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
22.22Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
22.22Single7PX4PSB-21137PX4-A2A-PSB-2113
22.22Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
22.22Single7TUYGSK682753A7TUY-GPR183-GSK682753A
22.22Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
22.22Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
22.22Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
22.22Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
22.22Single8E0GBU728E0G-μ-BU72
22.22Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
22.22Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
22.22Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.22Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
22.22Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
22.22Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
22.22Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
22.22Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensus5ht5_offOrthosteric Ligand5ht5a_off
22.22Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
22.22Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
22.22Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
22.22Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
22.22Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
22.22Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
22.22Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
22.22Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
22.22Consensuslpa_offOrthosteric Ligandlpa1_off
22.22Consensusrelaxin_onOrthosteric Ligandrxfp4_on
22.22Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
21.74Single6PT2KGCHM076PT2-δ-KGCHM07
21.74Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
21.74Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
21.43Single3OE9IT1t3OE9-CXCR4-IT1t
21.43Single5GLHEndothelin-15GLH-ETB-Endothelin-1
21.43Single6IGKEndothelin-36IGK-ETB-Endothelin-3
21.43Single6TP4ACT-4622066TP4-OX1-ACT-462206
21.43Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
21.43Single7SRQLSD7SRQ-5-HT2B-LSD
21.43Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
21.43Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
21.43Single8GH1Epinephrine8GH1-β2-Epinephrine
21.43Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
21.43Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
21.43Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
21.43Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
21.43Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
21.43Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
21.43Consensusgo_class-b2Orthosteric Ligandgo_adhesion
21.05Single5X33BIIL2605X33-BLT1-BIIL260
21.05Single6A93Risperidone6A93-5-HT2A-Risperidone
21.05Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
21.05Single6CM4Risperidone6CM4-D2-Risperidone
21.05Single6IIURamatroban6IIU-TP-Ramatroban
21.05Single6MXTSalmeterol6MXT-β2-Salmeterol
21.05Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
21.05Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.05Single7DFPSpiperone7DFP-D2-Spiperone
21.05Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
21.05Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
21.05Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
21.05Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
21.05Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
21.05Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
21.05Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.05Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
21.05Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
21.05Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
21.05Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
21.05Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
21.05Single8JJLOlodaterol8JJL-β2-Olodaterol
21.05Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
21.05Single8WU1KCA8WU1-CB1-KCA-Arrestin1
21.05Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
21.05Consensusdp_offOrthosteric Liganddp2_off
21.05Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
21.05Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
21.05Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.05Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
20.83Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
20.83Single6JODAngiotensin II6JOD-AT2-Angiotensin II
20.00Single3PWHZM2413853PWH-A2A-ZM241385
20.00Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
20.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
20.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
20.00Single5K2DZM2413855K2D-A2A-ZM241385
20.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
20.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
20.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
20.00Single5U09Taranabant5U09-CB1-Taranabant
20.00Single6AKXA4R6AKX-CCR5-A4R
20.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
20.00Single6JZHZM2413856JZH-A2A-ZM241385-Na
20.00Single6K1QIRL25006K1Q-ETB-IRL2500
20.00Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
20.00Single6PS7ZM2413856PS7-A2A-ZM241385-Na
20.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
20.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
20.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
20.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
20.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
20.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
20.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
20.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
20.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
20.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
20.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
20.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.00Single7XRRLemborexant7XRR-OX2-Lemborexant
20.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
20.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
20.00Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
20.00Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
20.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
20.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
20.00Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
20.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
20.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
19.23Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
19.23Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
19.23Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
19.23Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
19.23Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
19.05Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
19.05Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
19.05Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
19.05Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
19.05Consensusclass-d_offOrthosteric Ligandste2_off
19.05Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
19.05Consensuslpl_onOrthosteric Ligands1p_on lpa_on
19.05Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.75Single4MBSMaraviroc4MBS-CCR5-Maraviroc
18.75Single5IU4ZM2413855IU4-A2A-ZM241385-Na
18.75Single5IUBQ274563445IUB-A2A-Q27456344-Na
18.75Single5K2CZM2413855K2C-A2A-ZM241385-Na
18.75Single5NLXZM2413855NLX-A2A-ZM241385-Na
18.75Single5NM4ZM2413855NM4-A2A-ZM241385-Na
18.75Single6DS0Ly2660976DS0-5-HT2B-Ly266097
18.75Single6FFIMMPEP6FFI-mGlu5-MMPEP
18.75Single6IQLL7458706IQL-D4-L745870
18.75Single6TP3Nemorexant6TP3-OX1-Nemorexant
18.75Single6TPKRetosiban6TPK-OT-Retosiban
18.75Single6VI4JDTic6VI4-κ-JDTic
18.75Single6ZG9GSK10347026ZG9-M1-GSK1034702
18.75Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
18.75Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.75Single7VODCariprazine7VOD-5-HT2A-Cariprazine
18.75Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
18.75Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
18.75Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
18.75Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
18.75Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
18.75Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
18.75Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
18.75Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
18.75Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
18.75Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
18.75Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
18.75Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
18.75Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
18.75Consensusvasopressin-ot_offOrthosteric Ligandot_off
18.52Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
18.52Consensusendothelin_onOrthosteric Ligandetb_on eta_on
18.52Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
18.52Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
18.52Consensusgo_class-b1Orthosteric Ligandgo_crf
18.52Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.18Single5MZPCaffeine5MZP-A2A-Caffeine-Na
18.18Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
18.18Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
18.18Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
17.86Single6IGLIRL16206IGL-ETB-IRL1620
17.86Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
17.86Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
17.86Single8IY6Endothelin-18IY6-ETB-Endothelin-1
17.86Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.86Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
17.65Single4DAJTiotropium4DAJ-M3-Tiotropium
17.65Single4YAYZD-71554YAY-AT1-ZD-7155
17.65Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
17.65Single5DSGTiotropium5DSG-M4-Tiotropium
17.65Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
17.65Single6D27CAY104716D27-DP2-CAY10471
17.65Single6DRXLisuride6DRX-5-HT2B-Lisuride
17.65Single6FFHFenobam6FFH-mGlu5-Fenobam
17.65Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
17.65Single6LPJZM2413856LPJ-A2A-ZM241385-Na
17.65Single6LPKZM2413856LPK-A2A-ZM241385-Na
17.65Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
17.65Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
17.65Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
17.65Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
17.65Single7F83PF-051904577F83-Ghrelin-PF-05190457
17.65Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
17.65Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
17.65Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
17.65Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
17.65Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
17.65Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
17.65Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.65Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
17.65Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
17.65Single8K5DGSK2560738K5D-HCA2-GSK256073
17.65Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
17.65Single8X63Mepyramine8X63-H1-Mepyramine
17.65Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
17.65Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
17.65Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
17.65Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
17.65Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
17.65Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
17.65Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
17.65Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
17.65Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
17.65Consensustachykinin_offOrthosteric Ligandnk1_off
17.39Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
17.39Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
17.39Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
17.39Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
17.24Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
17.24Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
16.67Single4NTJAZD12834NTJ-P2Y12-AZD1283
16.67Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
16.67Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
16.67Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
16.67Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
16.67Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
16.67Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
16.67Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
16.67Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
16.67Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
16.67Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
16.67Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
16.67Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
16.67Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
16.67Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
16.67Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
16.67Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
16.67Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
16.67Single7WC4Serotonin7WC4-5-HT2A-Serotonin
16.67Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
16.67Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7YXAONO-54306087YXA-S1P5-ONO-5430608
16.67Single8EA0Iperoxo8EA0-M3-Iperoxo
16.67Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
16.67Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
16.67Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.67Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
16.67Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
16.67Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
16.67Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
16.67Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
16.67Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
16.67Consensusep_offOrthosteric Ligandep4_off
16.67Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.67Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
16.13Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.13Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
16.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
16.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
16.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
16.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
16.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
16.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
16.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
16.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
16.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
15.79Single5TZR-5TZR-FFA1 (GPR40)-MK8666
15.79Single5XR8AM8415XR8-CB1-AM841
15.79Single5XRAAM115425XRA-CB1-AM11542
15.79Single6E59L-7607356E59-NK1-L-760735
15.79Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
15.79Single7B6WCyclazosin7B6W-α1b-Cyclazosin
15.79Single7EPENAM5637EPE-mGlu-NAM563
15.79Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
15.79Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
15.79Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
15.79Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
15.79Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
15.79Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
15.79Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
15.79Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
15.79Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
15.79Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
15.79Consensuscck_onOrthosteric Ligandccka_on cckb_on
15.79Consensuschemerin_onOrthosteric Ligandcml1_on
15.79Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
15.79Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.79Consensuslpa_onOrthosteric Ligandlpa1_on
15.79Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
15.79Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
15.62Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
15.38Single3RFMCaffeine3RFM-A2A-Caffeine
15.38Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
15.38Single6TQ9SB-4081246TQ9-OX1-SB-408124
15.38Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
15.38Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
15.38Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
15.38Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
15.38Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.38Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
15.38Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
15.38Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
15.38Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
15.38Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
15.38Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.15Consensuspth_onOrthosteric Ligandpth1_on pth2_on
15.00Single4N4WSANT-14N4W-SMO-SANT-1
15.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
15.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
15.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
15.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
15.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
15.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
15.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
15.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
15.00Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
15.00Single8JWZAB9288JWZ-A2A-AB928-Na
15.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
15.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
15.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
15.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
15.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
15.00Consensusclass-b2_onOrthosteric Ligandadgrg_on
15.00Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
15.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
15.00Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
15.00Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
15.00Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
15.00Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
14.81Single6FJ3PTH6FJ3-PTH1-PTH
14.81Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.81Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.81Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
14.81Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
14.81Consensusclass-d_onOrthosteric Ligandste2_on
14.81Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
14.81Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
14.81Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
14.81Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single3OE6IT1t3OE6-CXCR4-IT1t
14.29Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
14.29Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
14.29Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
14.29Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
14.29Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.29Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
14.29Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
14.29Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
14.29Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
14.29Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
14.29Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
14.29Single7WC5Psilocin7WC5-5-HT2A-Psilocin
14.29Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
14.29Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
14.29Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
14.29Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
14.29Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
14.29Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
14.29Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
14.29Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
14.29Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
14.29Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
14.29Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
14.29Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
14.29Consensuscyslt_offOrthosteric Ligandcyslt2_off
14.29Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
14.29Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
14.29Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
14.29Consensusgi_class-dOrthosteric Ligandgi_ste
14.29Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.29Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
14.29Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
14.29Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.29Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusorexin_onOrthosteric Ligandox2_on
14.29Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
13.89Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
13.79Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.79Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
13.79Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
13.79Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
13.79Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
13.79Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
13.79Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
13.79Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
13.79Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
13.79Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
13.79Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.64Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
13.64Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
13.64Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
13.64Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
13.64Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
13.64Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
13.64Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
13.64Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
13.33Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
13.33Single5L7IVismodegib5L7I-SMO-Vismodegib
13.33Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
13.33Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
13.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
13.33Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
13.33Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
13.33Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.33Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
13.33Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.33Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
13.33Consensusclass-t_onOrthosteric Ligandtaste2_on
13.33Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
13.33Consensusgs_class-tOrthosteric Ligandgs_taste
13.33Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
13.33Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.33Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.04Single4XT1Fractalkine4XT1-US28-Fractalkine
13.04Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
13.04Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
13.04Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.04Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
13.04Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
13.04Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
13.04Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
13.04Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
13.04Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
13.04Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
13.04Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
13.04Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
12.90Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
12.90Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
12.90Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
12.50Single3ODUIT1t3ODU-CXCR4-IT1t
12.50Single5DHHSB-6121115DHH-NOP-SB-612111
12.50Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
12.50Single5ZKQABT-4915ZKQ-PAF-ABT-491
12.50Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
12.50Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.50Single7BR3Elagolix7BR3-GnRH1-Elagolix
12.50Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
12.50Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
12.50Single7F8ULintitript7F8U-CCKA-Lintitript
12.50Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.50Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
12.50Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
12.50Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
12.50Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
12.50Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
12.50Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
12.50Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
12.50Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
12.50Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
12.50Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
12.50Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
12.50Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
12.50Single8IHKAcifran8IHK-HCA3-Acifran
12.50Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.50Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
12.50Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
12.50Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
12.50Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
12.50Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
12.50Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
12.50Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
12.50Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
12.12Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
12.12Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
12.12Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
12.12Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
12.12Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
12.12Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
12.12Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
12.12Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
12.00Single3OE0CVX153OE0-CXCR4-CVX15
12.00Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
12.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
12.00Single7XNACYN1548067XNA-SST2-CYN154806
12.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
12.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
12.00Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
12.00Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
12.00Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
12.00Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
11.76Single3REYPubChem 56973REY-A2A-PubChem 5697
11.76Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
11.76Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
11.76Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
11.76Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
11.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.76Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
11.76Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
11.76Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
11.76Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
11.76Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
11.76Consensusgnrh_offOrthosteric Ligandgnrh1_off
11.76Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
11.76Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
11.54Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.54Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.54Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
11.54Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
11.54Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
11.54Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
11.54Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
11.54Consensusclass-d_onOrthosteric Ligandste2_on
11.54Consensusgi_class-dOrthosteric Ligandgi_ste
11.54Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
11.54Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
11.11Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
11.11Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
11.11Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
11.11Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
11.11Single6GPSMK08126GPS-CCR2-MK0812
11.11Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
11.11Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
11.11Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
11.11Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
11.11Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
11.11Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
11.11Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
11.11Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
11.11Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
11.11Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
11.11Consensuscck_offOrthosteric Ligandccka_off
11.11Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
11.11Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
11.11Consensushcar_offOrthosteric Ligandsuccinate_off
11.11Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
11.11Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
11.11Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
10.71Single4XT3Fractalkine4XT3-US28-Fractalkine
10.71Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
10.71Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
10.71Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
10.71Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
10.71Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
10.71Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.71Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
10.71Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
10.71Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.71Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
10.71Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
10.53Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
10.53Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
10.53Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
10.53Single6GPXMK08126GPX-CCR2-MK0812
10.53Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.53Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
10.53Single7C4SS1P7C4S-S1P3-S1P
10.53Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.53Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
10.53Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
10.53Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.53Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.53Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.53Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
10.53Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
10.53Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
10.53Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
10.53Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
10.53Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
10.34Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
10.34Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
10.34Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
10.34Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
10.34Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
10.34Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
10.34Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.26Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
10.26Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
10.00Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
10.00Single6LMLGlucagon6LML-Glucagon-Glucagon
10.00Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
10.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
10.00Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
10.00Single7P2L4YI7P2L-mGlu5-4YI
10.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
10.00Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
10.00Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
10.00Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
10.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
10.00Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
10.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
10.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.00Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
10.00Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
10.00Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
10.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
10.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
10.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
10.00Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
10.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
10.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
9.68Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single4PY02MeSATP4PY0-P2Y12-2MeSATP
9.52Single4XEENeurotensin4XEE-NTS1-Neurotensin
9.52Single4XESNeurotensin4XES-NTS1-Neurotensin
9.52Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
9.52Single6OS2TRV0266OS2-AT1-TRV026
9.52Single6YVRNTS8-136YVR-NTS1-NTS8-13
9.52Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
9.52Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
9.52Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
9.52Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
9.52Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
9.52Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
9.38Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
9.38Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
9.38Consensusglp_onOrthosteric Ligandglp1_on glp2_on
9.09Single4BUONeurotensin4BUO-NTS1-Neurotensin
9.09Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
9.09Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
9.09Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
9.09Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
9.09Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.82Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.70Single6KNMJN241-96KNM-Apelin-JN241-9
8.70Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
8.70Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.70Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
8.70Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
8.70Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
8.70Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
8.70Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
8.70Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
8.70Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
8.70Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Consensusgs_class-b2Orthosteric Ligandgs_adgr
8.70Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
8.70Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
8.57Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
8.33Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
8.33Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.33Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
8.33Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
8.33Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
8.33Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
8.33Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
8.33Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
8.33Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
8.33Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
8.11Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
8.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
8.00Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.00Single7SK5CXCL127SK5-ACKR3-CXCL12
8.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
8.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Consensussst_offOrthosteric Ligandsst2_off
7.89Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
7.69Single6W25SHU91196W25-MC4-SHU9119-Ca
7.69Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
7.69Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
7.41Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
7.41Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.41Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
7.14Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
7.14Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
7.14Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
7.14Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
7.14Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
7.14Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
6.90Single7SK3CXCL127SK3-ACKR3-CXCL12
6.90Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single3OE8IT1t3OE8-CXCR4-IT1t
6.67Single4XNWMRS25004XNW-P2Y1-MRS2500
6.67Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.67Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
6.67Single6LI0GTPL98046LI0-GPR52-GTPL9804
6.67Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
6.67Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
6.67Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
6.67Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
6.67Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
6.67Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
6.67Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
6.67Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
6.67Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
6.67Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.45Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
6.25Single4O9RCyclopamine4O9R-SMO-Cyclopamine
6.25Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
6.25Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
6.25Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.25Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
6.25Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
6.25Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
6.25Consensusgo_proteinOrthosteric Ligandgo_chemokine
6.25Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.06Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
5.88Single4BWBNeurotensin4BWB-NTS1-Neurotensin
5.88Single4K5YCP-3763954K5Y-CRF1-CP-376395
5.88Single4QINSAG1.54QIN-SMO-SAG1.5
5.88Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.88Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
5.88Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
5.88Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
5.88Single7F8YDevazepide7F8Y-CCKA-Devazepide
5.88Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.88Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.88Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
5.88Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.88Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
5.88Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
5.88Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
5.88Consensusclass-f_offOrthosteric Ligandsmo_off
5.88Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.88Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.88Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
5.71Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
5.56Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
5.56Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
5.56Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.56Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.56Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
5.56Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
5.56Single7VV6C48/807VV6-MRGPRX2-C48/80
5.56Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
5.56Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
5.56Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
5.56Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
5.56Single8IYXYL-3658IYX-GPR34-YL-365
5.56Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
5.56Single8K2WAMG4878K2W-CXCR3-AMG487
5.56Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.56Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
5.56Consensusgi_class-fOrthosteric Ligandgi_frizzled
5.56Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.56Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
5.56Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
5.56Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
5.56Consensuss1p_offOrthosteric Ligands1p1_off
5.26Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
5.26Single4Z9GCP-3763954Z9G-CRF1-CP-376395
5.26Single5T04Neurotensin5T04-NTS1-Neurotensin
5.26Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.26Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
5.26Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.26Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
5.26Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.26Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
5.26Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
5.26Single8GTIBMK-C2058GTI-CRF1-BMK-C205
5.26Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.26Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
5.26Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
5.26Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
5.26Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
5.00Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
5.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
5.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
5.00Single8GTGBMK-I1528GTG-CRF1-BMK-I152
5.00Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.76Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
4.76Single4BV0Neurotensin4BV0-NTS1-Neurotensin
4.76Single5V56TC1145V56-SMO-TC114
4.76Single5V57TC1145V57-SMO-TC114
4.76Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
4.76Single6OS1TRV0266OS1-AT1-TRV026
4.76Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.76Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.76Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
4.76Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
4.76Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
4.76Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
4.76Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
4.76Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
4.76Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
4.76Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.55Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.55Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
4.55Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
4.55Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
4.55Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
4.55Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single8GTMBMK-C2038GTM-CRF1-BMK-C203
4.55Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.55Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.55Consensuschemokine_offOrthosteric Ligandcxcr_off
4.55Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
4.55Consensuscxcr_offOrthosteric Ligandcxcr4_off
4.55Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
4.55Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.55Consensusnts_offOrthosteric Ligandnts1_off
4.55Consensusnts_onOrthosteric Ligandnts1_on
4.35Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
4.35Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
4.35Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.35Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.35Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.35Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
4.35Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.17Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
3.85Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
3.70Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
3.57Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.45Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.12Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
3.03Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
3.03Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.03Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.94Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.86Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.86Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.78Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.78Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.63Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.50Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.44Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.33Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

Consensus Members
Id Members
gt_sensory 6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
Net Summary
Imin 1.71
Number of Linked Nodes 822
Number of Links 1127
Number of Hubs 222
Number of Links mediated by Hubs 799
Number of Communities 16
Number of Nodes involved in Communities 347
Number of Links involved in Communities 573
Path Summary
Number Of Nodes in MetaPath 76
Number Of Links MetaPath 75
Number of Shortest Paths 2556411
Length Of Smallest Path 3
Average Path Length 28.3069
Length of Longest Path 48
Minimum Path Strength 1.27
Average Path Strength 5.4965
Maximum Path Strength 42.165
Minimum Path Correlation 0.7
Average Path Correlation 0.986536
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 38.789
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 60.3271
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gt_class-agt_opsin



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