Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1NT.H20 11.0625417
2NT.I22 5.3225414
3NT.F30 6.59167615
4NT.V37 3.9525416
5NT.I40 4.472515
6NT.P41 4.90833619
7NT.L44 7.9475412
8NT.L51 5.9075418
9NT.V60 3.674104
10NT.I61 5.864518
11NT.F66 5.58667618
12NT.L72 6.115407
13NT.I75 5.915417
14NT.Q79 8.665427
15NT.I86 6.184518
16NT.V90 5.91419
17NT.F91 6.788519
18NT.L97 5.655418
19NT.E99 7.02426
20NT.I100 4.5325418
21NT.R101 10.07425
22NT.K104 15.6525426
23NT.L108 5.4225419
24NT.N112 3.15415
25NT.F116 6.2419
26NT.L122 4.01419
27NT.Y124 10.706526
28NT.L126 10.86427
29NT.I127 4.99619
30NT.T130 4.638518
31NT.I132 5.008517
32NT.I141 4.2075418
33NT.V147 4.255416
34NT.L149 5.6675418
35NT.D150 9.95427
36NT.I151 4.13517
37NT.Q152 7.86833627
38NT.I160 4.986516
39NT.F165 5.455617
40NT.L168 6.27415
41NT.I174 6.66425
42NT.L175 5.07517
43NT.W176 7.436526
44NT.L177 4.71419
45NT.N178 11.005425
46NT.K179 7.862526
47NT.F190 5.5509
48NT.N191 4.3225405
49NT.L198 6.6725467
50NT.S201 8.14427
51NT.L206 4.64488
52NT.L209 4.8525487
53NT.V213 4.805408
54NT.F214 6.704509
55NT.P220 5.545468
56NT.L223 3.5875468
57NT.I230 4.7425488
58NT.Y271 7.932509
59NT.I273 3.02408
60NT.F278 4.4625408
61NT.H289 3.8725423
62NT.I359 6.0925448
631x36 8.455409
641x39 4.81538
652x38 3.4965138
662x40 3.51833678
672x46 6.98458
682x50 7.778559
692x53 4.4225407
702x56 7.314537
712x57 3.8775408
72E1.Y429 6.466549
73E1.N431 8.1525445
74E1x50 4.4225449
753x30 7.8154148
763x38 5.395407
773x49 5.35754139
783x50 5.78409
793x51 7.03405
804x50 6.35496
81E2.Y511 8.756538
82E2.I516 3.942538
83E2x51 6.395638
84E2x52 5.2025439
85E2.D521 5.0454168
865x39 7.3525407
875x43 5.2075406
885x51 7.3175409
895x58 8.288509
906x59 4.668507
91E3.L601 3.095406
927x37 6.0525437
937x40 6.334177
947x41 6.1406
957x49 7.244559
967x53 6.74459
977x55 5.4775407
988x50 4.3625408
998x53 6.2075478
100Lig 136.542120
101Allo1 7.152731130
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1NT.F30 NT.P45 11.692610.11YesNo152
2NT.N47 NT.P45 11.61744.89NoNo052
3NT.N47 NT.R28 11.27478.44NoNo051
4NT.I49 NT.R28 10.246611.27NoNo031
5NT.F30 NT.L51 13.05073.65YesYes158
6NT.A65 NT.F66 38.28985.55NoYes158
7NT.F53 NT.L51 15.06298.53NoYes068
8NT.F53 NT.I77 15.56015.02NoNo068
9NT.A65 NT.Q62 39.16813.03NoNo054
10NT.E87 NT.Q62 38.79832.55NoNo064
11NT.E87 NT.V60 38.05874.28NoYes064
12NT.R59 NT.V60 36.95111.31NoYes024
13NT.R59 NT.V82 36.58281.31NoNo025
14NT.I102 NT.I77 15.8894.42NoNo088
15NT.F66 NT.F91 44.17964.29YesYes189
16NT.D81 NT.V82 35.84667.3NoNo075
17NT.F116 NT.F91 48.347413.93YesYes199
18NT.I102 NT.I127 25.887210.3NoYes089
19NT.F116 NT.P136 51.75464.33YesNo199
20NT.I127 NT.I151 34.154.42YesYes197
21NT.I151 NT.L135 17.42294.28YesNo077
22NT.I160 NT.L135 17.47754.28YesNo067
23NT.I151 NT.L149 34.39654.28YesYes178
24NT.F165 NT.L149 34.40557.31YesYes178
25NT.I151 NT.L177 34.39654.28YesYes179
26NT.F165 NT.L177 34.40554.87YesYes179
27NT.I160 NT.I185 17.60845.89YesNo067
28NT.F165 NT.F190 73.66424.29YesYes079
29NT.I185 NT.L206 16.91675.71NoYes078
30NT.F190 NT.F214 77.96093.22YesYes099
31NT.I230 NT.L206 16.84364.28YesYes888
32NT.F214 NT.P234 40.66087.22YesNo099
33NT.F214 NT.L238 40.73733.65YesNo098
34NT.I225 NT.I230 18.26574.42NoYes088
35NT.A246 NT.I225 18.27853.25NoNo088
36NT.L233 NT.P234 41.90114.93NoNo089
37NT.L233 NT.L238 41.55074.15NoNo088
38NT.L233 NT.P256 83.31344.93NoNo087
39NT.A246 NT.T249 18.29215.03NoNo087
40NT.T249 NT.T270 18.3236.28NoNo078
41NT.T270 NT.Y271 18.35088.74NoYes089
42NT.L255 NT.P256 82.63344.93NoNo067
43NT.H274 NT.L255 82.40516.43NoNo096
44NT.H274 NT.Y271 82.29095.44NoYes099
45E1.I434 NT.Y271 10018.13NoYes079
46E1.A433 E1.Y429 97.55018.01NoYes099
47E1.A433 NT.I273 97.70673.25NoYes098
48E1.I434 NT.I273 99.6942.94NoYes078
492x60 E2.I516 25.98122.94NoYes388
501x39 2x60 38.78552.94YesNo388
511x39 NT.M360 87.77895.83YesNo387
522x64 NT.M360 93.32039.7NoNo097
532x64 NT.I359 94.8049.8NoYes098
54E1.Y429 NT.I359 95.81688.46YesYes498
552x57 7x42 36.21083.28YesNo089
561x39 2x57 49.15235.71YesYes088
572x40 I1x51 11.23343.88YesNo087
582x39 I1x51 11.48236.99NoNo067
592x39 3x49 11.65849.43NoYes1369
603x49 3x50 14.17563.49YesYes099
613x50 7x53 22.97288.23YesYes099
627x49 7x53 32.62333.49YesYes599
632x50 7x49 33.75138.08YesYes599
642x50 7x46 35.31388.83YesNo099
652x53 7x46 35.73936.19YesNo079
662x53 3x36 36.38263.1YesNo078
673x36 7x41 35.30988.37NoYes086
687x41 7x42 35.73463.05YesNo069
69E2x51 E2x52 12.20853.28YesYes389
70E2.I516 E2x51 24.4925.71YesYes388
712x56 2x57 12.77993.52YesYes078
722x56 2x60 12.67479.67YesNo378
732x56 7x37 24.55393.52YesYes377
74Allo1 E2x51 12.094815.27YesYes308
757x37 Allo1 24.11354.77YesYes370
766x59 Allo1 23.48613.11YesYes070
775x41 6x59 10.37256.13NoYes067
785x44 6x56 17.95784.28NoNo087
796x55 Allo1 10.34247.6NoYes080
806x52 6x56 24.92544.64NoNo097
815x51 6x48 16.73836.22YesNo097
826x48 6x52 18.78293.07NoNo079
835x51 5x55 10.56038.38YesNo097
84Lig NT.D81 35.47594.34YesNo207
85NT.I151 NT.P136 51.74433.39YesNo179
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
NT.L31NT.Q335.320NoNo4421
LigNT.Q335.162YesNo0401
NT.L55NT.Q793.990NoYes4721
NT.Q79NT.S784.332YesNo7512
NT.K104NT.Q7913.562YesYes6711
LigNT.Q7912.782YesYes0701
NT.D81NT.V827.32NoNo7512
LigNT.D814.342YesNo0701
NT.E99NT.R1016.982YesYes6522
NT.E99NT.Y1246.732YesYes6621
NT.E103NT.R1015.822NoYes5512
NT.R101NT.Y1249.262YesYes5621
NT.L126NT.R10118.222YesYes7522
NT.E103NT.K10418.92NoYes5611
LigNT.E10312.372YesNo0501
NT.K104NT.N1294.22YesNo6812
LigNT.K10425.952YesYes0601
NT.N106NT.N10714.982NoNo6512
LigNT.N1064.122YesNo0601
NT.L126NT.Y1248.212YesYes7621
NT.L148NT.Y1243.522NoYes5621
LigNT.Y12425.812YesYes0601
NT.L126NT.S1287.512YesNo7722
NT.D150NT.L1269.52YesYes7722
NT.D150NT.S1285.892YesNo7722
NT.Q152NT.S1285.782YesNo7712
NT.I174NT.L1488.562YesNo5522
NT.L148NT.W17610.252NoYes5622
NT.D150NT.Q15214.362YesYes7721
NT.D150NT.W17610.052YesYes7622
NT.Q152NT.W1764.382YesYes7612
NT.N178NT.Q15213.22YesYes5721
NT.K179NT.Q1524.072YesYes6711
LigNT.Q1525.422YesYes0701
NT.D153NT.K1796.912NoYes6611
LigNT.D1538.372YesNo0601
NT.D196NT.S1728.832NoNo4512
NT.I174NT.W1767.052YesYes5622
NT.D196NT.I1744.22NoYes4512
NT.K179NT.N1788.392YesYes6512
NT.D202NT.K17912.440NoYes5621
LigNT.K1797.52YesYes0601
LigNT.D1963.222YesNo0401
NT.I222NT.V2216.140NoNo3121
LigNT.V2217.072YesNo0101
NT.I222NT.K2437.270NoNo3521
NT.E266NT.K2438.10NoNo4521
LigNT.K2434.822YesNo0501
NT.E287NT.H2896.150NoYes2321
NT.C338NT.H2894.422NoYes8321
LigNT.H2893.392YesYes0301
LigNT.I29125.212YesNo0201
NT.C292NT.L3374.762NoNo1121
NT.C292NT.C3387.282NoNo1822
NT.T329NT.Y3303.752NoNo4412
NT.E332NT.F3334.660NoNo5321
LigNT.Y33535.842YesNo0401
NT.C338NT.L3373.172NoNo8121
LigNT.L3373.72YesNo0101
LigNT.T3292.52YesNo0401
NT.I291NT.S2951.552NoNo2512
NT.H289NT.P2901.532YesNo3112
NT.K242NT.V2211.520NoNo6121
LigNT.F3331.442YesNo0301

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
100.00Single6D35Cholesterol6D35-SMO-Cholesterol
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
100.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
100.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
100.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
100.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
100.00Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00Single7FIIhCG7FII-LH-hCG-6fuf
100.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
100.00Single7XW7K1-707XW7-TSH-K1-70
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
100.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
100.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
100.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
100.00Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
100.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
100.00Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusgphr_onOrthosteric Ligandlh_on tsh_on
100.00Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00Consensusgs_proteinOrthosteric Ligandgs_gphr
100.00Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
100.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
100.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
100.00Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
100.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
100.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
100.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
100.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
100.00Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
100.00Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
100.00Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
33.33Single8HS2Fab0468HS2-GPR20-Fab046
25.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
20.00Single5L7DCholesterol5L7D-SMO-Cholesterol
20.00Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
20.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
20.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29Single4XNWMRS25004XNW-P2Y1-MRS2500
14.29Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
14.29Single6LI0GTPL98046LI0-GPR52-GTPL9804
14.29Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.29Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
14.29Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
12.50Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
12.50Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50Consensusgo_proteinOrthosteric Ligandgo_chemokine
12.50Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.11Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
11.11Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Consensusclass-f_offOrthosteric Ligandsmo_off
11.11Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
10.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00Single7VV6C48/807VV6-MRGPRX2-C48/80
10.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
10.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
10.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
10.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
10.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
10.00Consensuss1p_offOrthosteric Ligands1p1_off
9.09Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single5TGZAM65385TGZ-CB1-AM6538
9.09Single6D27CAY104716D27-DP2-CAY10471
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
9.09Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
9.09Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
9.09Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
9.09Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.33Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
8.33Single5C1MBU725C1M-μ-BU72
8.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33Single7C4SS1P7C4S-S1P3-S1P
8.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
8.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
8.33Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
8.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YXAONO-54306087YXA-S1P5-ONO-5430608
8.33Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.33Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
7.69Single4BV0Neurotensin4BV0-NTS1-Neurotensin
7.69Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
7.69Single5V56TC1145V56-SMO-TC114
7.69Single5V57TC1145V57-SMO-TC114
7.69Single6OS1TRV0266OS1-AT1-TRV026
7.69Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
7.69Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
7.69Single7F1TMIP-1a7F1T-CCR5-MIP-1a
7.69Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
7.69Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
7.69Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
7.69Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
7.69Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
7.69Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7.69Single8E0GBU728E0G-μ-BU72
7.69Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.69Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.69Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
7.69Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.69Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7.69Consensuslpa_offOrthosteric Ligandlpa1_off
7.69Consensuslpa_onOrthosteric Ligandlpa1_on
7.69Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7.69Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
7.14Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
7.14Single4XEENeurotensin4XEE-NTS1-Neurotensin
7.14Single4XESNeurotensin4XES-NTS1-Neurotensin
7.14Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
7.14Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
7.14Single6OS2TRV0266OS2-AT1-TRV026
7.14Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
7.14Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single6YVRNTS8-136YVR-NTS1-NTS8-13
7.14Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
7.14Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7.14Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
7.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.14Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
7.14Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
7.14Consensuschemokine_offOrthosteric Ligandcxcr_off
7.14Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
7.14Consensuscxcr_offOrthosteric Ligandcxcr4_off
7.14Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
7.14Consensusdp_offOrthosteric Liganddp2_off
7.14Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
7.14Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.14Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.14Consensusnts_onOrthosteric Ligandnts1_on
7.14Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
7.14Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
6.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
6.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
6.67Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
6.67Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
6.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
6.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.67Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
6.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
6.67Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.67Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.67Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.67Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
6.25Single6KNMJN241-96KNM-Apelin-JN241-9
6.25Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
6.25Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
6.25Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.25Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.25Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
6.25Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.25Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
6.25Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25Consensuslpl_offOrthosteric Ligands1p_off lpa_off
6.25Consensuslpl_onOrthosteric Ligands1p_on lpa_on
6.25Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
6.25Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
5.88Single4XT1Fractalkine4XT1-US28-Fractalkine
5.88Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.88Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.88Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
5.88Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
5.88Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
5.88Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.88Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
5.88Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.88Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.88Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.88Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
5.88Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.88Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.88Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
5.88Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
5.56Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
5.56Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.56Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
5.56Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.56Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.56Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
5.56Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.56Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.56Single7SK5CXCL127SK5-ACKR3-CXCL12
5.56Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.56Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.56Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
5.56Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
5.26Single3OE0CVX153OE0-CXCR4-CVX15
5.26Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
5.26Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.26Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
5.26Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
5.26Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.26Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.26Consensusangiotensin_onOrthosteric Ligandat1_on
5.26Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.26Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
5.26Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.26Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.26Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
5.26Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
5.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
5.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
5.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
5.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
5.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
5.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
5.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
5.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
5.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
5.00Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
5.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
5.00Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
5.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.00Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
5.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.76Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.76Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
4.76Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.76Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.76Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.76Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.76Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
4.76Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.76Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.76Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
4.76Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
4.76Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.76Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
4.76Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
4.55Single4XT3Fractalkine4XT3-US28-Fractalkine
4.55Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.55Single6FJ3PTH6FJ3-PTH1-PTH
4.55Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.55Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.55Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7SK3CXCL127SK3-ACKR3-CXCL12
4.55Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
4.55Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
4.55Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.55Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
4.55Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.55Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.55Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
4.55Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.55Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
4.35Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.35Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.35Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
4.35Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.35Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.35Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
4.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.35Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.35Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.35Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
4.35Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.35Consensusgo_class-b1Orthosteric Ligandgo_crf
4.35Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.35Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.17Single6LMLGlucagon6LML-Glucagon-Glucagon
4.17Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.17Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.17Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.17Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.17Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.17Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
4.17Single8IY6Endothelin-18IY6-ETB-Endothelin-1
4.17Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
4.17Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
4.17Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.17Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.17Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.17Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.17Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.17Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
4.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
4.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
4.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.00Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.00Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.00Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
4.00Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
3.85Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.85Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.85Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.85Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.85Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.85Consensusglp_onOrthosteric Ligandglp1_on glp2_on
3.85Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
3.70Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.70Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.70Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.70Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.70Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
3.57Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.57Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.57Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.57Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.57Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.57Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
3.57Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.57Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
3.57Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.45Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
3.45Consensuspth_onOrthosteric Ligandpth1_on pth2_on
3.33Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.33Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.23Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.23Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
3.23Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.12Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.12Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.12Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.03Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
3.03Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.94Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.86Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x533x363.10YesNo7821
2x563x3216.233YesNo7822
2x56E2.I5163.633YesYes7822
2x567x373.523YesYes7721
3x32E2x512.950NoYes8821
3x33E2.Y5116.313NoYes8822
3x33E2x523.533NoYes8921
3x367x418.370NoYes8612
3x36Allo15.180NoYes8010
E2.Y511E2x528.343YesYes8921
E2.I516E2.V5143.073YesNo8822
E2.M520E2.V5149.133NoNo8812
E2.I516E2x515.713YesYes8821
E2x51E2x523.283YesYes8911
E2.M520E2x514.243NoYes8811
7x37E2x516.923YesYes7811
Allo1E2x5115.273YesYes0801
Allo1E2x525.663YesYes0901
Allo1E2.M52015.593YesNo0801
6x59E2.I5224.640YesNo7612
5x406x596.460NoYes7721
5x416x596.130NoYes6721
5x446x554.730NoNo8821
5x446x5930NoYes8721
6x517x413.980NoYes9612
6x51Allo17.870NoYes9010
6x55Allo17.60NoYes8010
6x58Allo18.690NoYes9010
6x59Allo13.110YesYes7010
7x33Allo13.260NoYes7010
7x377x4193YesYes7612
7x37Allo14.773YesYes7010
Allo1NT.F3531.683YesNo0801

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
84.62Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
64.29Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
61.54Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
56.25Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
56.25Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
50.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
46.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
46.67Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
42.11Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
41.18Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
41.18Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
40.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
40.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
38.89Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
37.50Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
37.50Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
36.84Single7EZCUKA7EZC-A2A-UKA
36.84Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
35.71Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
35.29Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
35.29Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
35.29Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
35.29Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
35.29Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Single5WF6UK-4320975WF6-A2A-UK-432097
35.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
34.78Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
33.33Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
33.33Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
33.33Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
33.33Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
33.33Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
33.33Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
33.33Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
33.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
33.33Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
33.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
33.33Single8GNGIstradefylline8GNG-A2A-Istradefylline
33.33Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
33.33Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
33.33Single8PWNTheophylline8PWN-A2A-Theophylline
33.33Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
33.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Consensuscck_onOrthosteric Ligandccka_on cckb_on
33.33Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
33.33Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
32.00Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
31.82Single3QAKUK-4320973QAK-A2A-UK-432097
31.82Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
31.82Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
31.58Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
31.58Single6MXTSalmeterol6MXT-β2-Salmeterol
31.58Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
31.58Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
31.58Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
31.58Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
31.58Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
31.58Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
31.58Consensusclass-b2_onOrthosteric Ligandadgrg_on
31.25Single2YDOAdenosine2YDO-A2A-Adenosine
31.25Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
31.25Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
31.25Single6MH8ZM2413856MH8-A2A-ZM241385
31.25Single8GGLEpinephrine8GGL-β2-Epinephrine
30.77Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
30.77Single8A2OTheophylline8A2O-A2A-Theophylline-Na
30.43Single5WF5UK-4320975WF5-A2A-UK-432097
30.43Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
30.43Consensusangiotensin_onOrthosteric Ligandat1_on
30.43Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.43Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
30.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
30.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
30.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
30.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
30.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
30.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
30.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
30.00Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
29.63Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
29.63Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
29.63Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
29.63Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
29.41Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
29.41Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
29.41Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
29.41Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
29.41Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
29.41Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
29.41Consensusadenosine_onOrthosteric Liganda1_on a2_on
29.41Consensusnucleotide_onOrthosteric Ligandadenosine_on
29.17Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
29.17Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.17Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
29.17Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
29.17Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
28.57Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
28.57Single6ME5Agomelatine6ME5-MT1-Agomelatine
28.57Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
28.57Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
28.57Single7XN9L-054,5227XN9-SST2-L-054,522
28.57Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
28.57Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
28.57Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
28.57Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
28.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
28.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
28.00Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
28.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
27.78Single5N2SPSB365N2S-A1-PSB36
27.78Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
27.78Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
27.78Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
27.78Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
27.78Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
27.78Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
27.78Single8GNEKW-63568GNE-A2A-KW-6356-Na
27.78Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
27.78Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
27.78Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
27.78Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
27.78Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
27.78Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
27.27Single4IARErgotamine4IAR-5-HT1B-Ergotamine
27.27Single7F8XNN90567F8X-CCKA-NN9056
27.27Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
27.27Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
27.27Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
27.27Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
27.27Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
27.27Consensussst_onOrthosteric Ligandsst2_on sst4_on
26.92Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
26.67Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
26.67Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
26.67Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
26.67Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
26.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
26.67Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
26.67Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
26.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
26.67Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
26.32Single2YDVNECA2YDV-A2A-NECA
26.32Single4RWADIPP-NH24RWA-δ-DIPP-NH2
26.32Single4UHRCGS216804UHR-A2A-CGS21680
26.32Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
26.32Single5G53NECA5G53-A2A-NECA-Gs
26.32Single6J21Aprepitant6J21-NK1-Aprepitant
26.32Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
26.32Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
26.32Single6WGTLSD6WGT-5-HT2A-LSD
26.32Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
26.32Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
26.32Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
26.32Single7PX4PSB-21137PX4-A2A-PSB-2113
26.32Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
26.32Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
26.32Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
26.32Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
26.32Consensusa2_onOrthosteric Liganda2a_on a2b_on
26.32Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
26.32Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
26.32Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
26.32Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
26.32Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
26.32Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
26.09Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
26.09Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
26.09Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
25.81Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.81Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.81Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.81Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
25.00Single3PWHZM2413853PWH-A2A-ZM241385
25.00Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
25.00Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
25.00Single4AMIBucindolol4AMI-β1-Bucindolol
25.00Single4N4WSANT-14N4W-SMO-SANT-1
25.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
25.00Single4XESNeurotensin4XES-NTS1-Neurotensin
25.00Single5K2DZM2413855K2D-A2A-ZM241385
25.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
25.00Single6JZHZM2413856JZH-A2A-ZM241385-Na
25.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
25.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
25.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
25.00Single6OS2TRV0266OS2-AT1-TRV026
25.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
25.00Single6PS7ZM2413856PS7-A2A-ZM241385-Na
25.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
25.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
25.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
25.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
25.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
25.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
25.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
25.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
25.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
25.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
25.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
25.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
25.00Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
25.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
25.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
25.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
25.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
25.00Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
25.00Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
25.00Single8JJLOlodaterol8JJL-β2-Olodaterol
25.00Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
25.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
25.00Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
25.00Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
25.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
25.00Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
25.00Consensusdp_offOrthosteric Liganddp2_off
25.00Consensusgi_class-fOther Ligandgi_frizzled
25.00Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
25.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
25.00Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
25.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
25.00Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
25.00Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgs_steroidOrthosteric Ligandgs_bileacid
25.00Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
25.00Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
25.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
24.14Single5GLHEndothelin-15GLH-ETB-Endothelin-1
24.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
24.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
24.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
24.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
24.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
24.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
24.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
24.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
23.81Single4BUONeurotensin4BUO-NTS1-Neurotensin
23.81Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
23.81Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
23.81Single6IBLArformoterol6IBL-β1-Arformoterol
23.81Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
23.81Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
23.81Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
23.81Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
23.81Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
23.81Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
23.81Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
23.81Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
23.81Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
23.81Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
23.81Consensussteroid_onOrthosteric Ligandbileacid_on
23.53Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
23.53Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
23.53Single5IU4ZM2413855IU4-A2A-ZM241385-Na
23.53Single5IU7Q274563465IU7-A2A-Q27456346-Na
23.53Single5IUBQ274563445IUB-A2A-Q27456344-Na
23.53Single5JTBZM2413855JTB-A2A-ZM241385
23.53Single5K2BZM2413855K2B-A2A-ZM241385-Na
23.53Single5K2CZM2413855K2C-A2A-ZM241385-Na
23.53Single5NLXZM2413855NLX-A2A-ZM241385-Na
23.53Single5NM4ZM2413855NM4-A2A-ZM241385-Na
23.53Single5UVIZM2413855UVI-A2A-ZM241385
23.53Single6AQFZM2413856AQF-A2A-ZM241385
23.53Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
23.53Single6PS4ICI 118-5516PS4-β2-ICI 118-551
23.53Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
23.53Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
23.53Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
23.53Single7AROLUF58337ARO-A2A-LUF5833-Na
23.53Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
23.53Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
23.53Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
23.53Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
23.53Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
23.53Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
23.53Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
23.53Single7VV6C48/807VV6-MRGPRX2-C48/80
23.53Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
23.53Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
23.53Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
23.53Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8GGKEpinephrine8GGK-β2-Epinephrine
23.53Single8GGMEpinephrine8GGM-β2-Epinephrine
23.53Single8GGPEpinephrine8GGP-β2-Epinephrine
23.53Single8GGQEpinephrine8GGQ-β2-Epinephrine
23.53Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
23.53Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
23.53Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
23.53Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
23.53Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
23.53Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
23.53Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
23.53Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
23.53Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
23.53Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
23.53Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
23.53Consensusgnrh_offOrthosteric Ligandgnrh1_off
23.53Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
23.53Consensushca_onOrthosteric Ligandhca2_on hca3_on
23.53Consensushcar_onOrthosteric Ligandhca_on
23.08Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
23.08Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
23.08Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
23.08Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
23.08Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
23.08Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single3NY9PubChem 9131033NY9-β2-PubChem 913103
22.73Single4UG2CGS216804UG2-A2A-CGS21680
22.73Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
22.73Single6KNMJN241-96KNM-Apelin-JN241-9
22.73Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
22.73Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
22.73Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
22.73Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
22.73Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
22.73Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
22.73Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
22.73Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Consensusgs_class-b2Orthosteric Ligandgs_adgr
22.73Consensuslpl_onOrthosteric Ligands1p_on lpa_on
22.73Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
22.58Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
22.22Single2Y02Carmoterol2Y02-β1-Carmoterol
22.22Single3EMLZM2413853EML-A2A-ZM241385
22.22Single3NY8ICI 118-5513NY8-β2-ICI 118-551
22.22Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
22.22Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
22.22Single4EIYZM2413854EIY-A2A-ZM241385-Na
22.22Single4EJ4Naltrindole4EJ4-δ-Naltrindole
22.22Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
22.22Single5IU8Q274563475IU8-A2A-Q27456347-Na
22.22Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
22.22Single5K2AZM2413855K2A-A2A-ZM241385-Na
22.22Single5OLGZM2413855OLG-A2A-ZM241385-Na
22.22Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
22.22Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
22.22Single5UENDU1725UEN-A1-DU172
22.22Single5VRAZM2413855VRA-A2A-ZM241385-Na
22.22Single6D27CAY104716D27-DP2-CAY10471
22.22Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
22.22Single6FJ3PTH6FJ3-PTH1-PTH
22.22Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
22.22Single6LPJZM2413856LPJ-A2A-ZM241385-Na
22.22Single6LPKZM2413856LPK-A2A-ZM241385-Na
22.22Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
22.22Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
22.22Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
22.22Single6PS1Timolol6PS1-β2-Timolol
22.22Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
22.22Single6S0LZM2413856S0L-A2A-ZM241385
22.22Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
22.22Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
22.22Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
22.22Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
22.22Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
22.22Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
22.22Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
22.22Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
22.22Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
22.22Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
22.22Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
22.22Single7PYRPSB-21157PYR-A2A-PSB-2115
22.22Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
22.22Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
22.22Single7UL4Alvimopan7UL4-μ-Alvimopan
22.22Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
22.22Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
22.22Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
22.22Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
22.22Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
22.22Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
22.22Single8CU6LJ-45178CU6-A2A-LJ-4517
22.22Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
22.22Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
22.22Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
22.22Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGJEpinephrine8GGJ-β2-Epinephrine
22.22Single8GGNEpinephrine8GGN-β2-Epinephrine
22.22Single8GGOEpinephrine8GGO-β2-Epinephrine
22.22Single8GGUEpinephrine8GGU-β2-Epinephrine
22.22Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
22.22Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
22.22Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
22.22Single8JJOAlprenolol8JJO-β2-Alprenolol
22.22Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
22.22Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
22.22Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
22.22Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
22.22Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
22.22Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
22.22Consensusa2_offOrthosteric Liganda2a_off
22.22Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
22.22Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
22.22Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
22.22Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
22.22Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
22.22Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
22.22Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
22.22Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
22.22Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
22.22Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
22.22Consensusgi_hcarOrthosteric Ligandgi_hca
22.22Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.22Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
22.22Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
21.74Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
21.74Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
21.74Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
21.74Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
21.74Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
21.74Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
21.74Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
21.74Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
21.74Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
21.74Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
21.43Single3RFMCaffeine3RFM-A2A-Caffeine
21.43Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
21.43Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
21.43Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
21.43Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
21.43Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
21.43Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
21.43Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
21.21Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
21.05Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
21.05Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
21.05Single5C1MBU725C1M-μ-BU72
21.05Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
21.05Single5IUAQ274563485IUA-A2A-Q27456348-Na
21.05Single5NM2ZM2413855NM2-A2A-ZM241385-Na
21.05Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
21.05Single5TVNLSD5TVN-5-HT2B-LSD
21.05Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
21.05Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
21.05Single6D26Fevipiprant6D26-DP2-Fevipiprant
21.05Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
21.05Single6E67BI1671076E67-β2-BI167107-Gs (fused)
21.05Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
21.05Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
21.05Single6LPLZM2413856LPL-A2A-ZM241385-Na
21.05Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
21.05Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
21.05Single6PS6Timolol6PS6-β2-Timolol
21.05Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
21.05Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
21.05Single6S0QZM2413856S0Q-A2A-ZM241385
21.05Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
21.05Single6WQAZM2413856WQA-A2A-ZM241385-Na
21.05Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
21.05Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
21.05Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
21.05Single7RM5ZM2413857RM5-A2A-ZM241385-Na
21.05Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
21.05Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
21.05Single7XKAEpinephrine7XKA-β2-Epinephrine
21.05Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
21.05Single8FYNZM2413858FYN-A2A-ZM241385-Na
21.05Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
21.05Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
21.05Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
21.05Single8QOTNanobody E8QOT-μ-Nanobody E
21.05Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
21.05Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
21.05Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
21.05Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
21.05Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
21.05Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
21.05Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
21.05Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
21.05Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
21.05Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
21.05Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
21.05Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
20.83Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
20.83Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
20.83Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
20.83Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.83Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
20.83Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
20.83Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.83Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
20.83Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
20.83Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
20.69Single6IGLIRL16206IGL-ETB-IRL1620
20.69Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
20.69Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
20.69Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
20.69Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
20.69Single8IY6Endothelin-18IY6-ETB-Endothelin-1
20.00Single3OE0CVX153OE0-CXCR4-CVX15
20.00Single3P0GBI1671073P0G-β2-BI167107
20.00Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
20.00Single3UZAGTPL92363UZA-A2A-GTPL9236
20.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
20.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
20.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
20.00Single4XNWMRS25004XNW-P2Y1-MRS2500
20.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
20.00Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
20.00Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
20.00Single5V56TC1145V56-SMO-TC114
20.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
20.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
20.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
20.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
20.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
20.00Single6J20Aprepitant6J20-NK1-Aprepitant
20.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
20.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
20.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
20.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
20.00Single6OS1TRV0266OS1-AT1-TRV026
20.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
20.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
20.00Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
20.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
20.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
20.00Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
20.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
20.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
20.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
20.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
20.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
20.00Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
20.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
20.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
20.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
20.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
20.00Single7W41PD1762527W41-BB2-PD176252
20.00Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
20.00Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
20.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
20.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
20.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
20.00Single8E0GBU728E0G-μ-BU72
20.00Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
20.00Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
20.00Single8GGREpinephrine8GGR-β2-Epinephrine
20.00Single8GGZEpinephrine8GGZ-β2-Epinephrine
20.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
20.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
20.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
20.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
20.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
20.00Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
20.00Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
20.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
20.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
20.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
20.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
20.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
20.00Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
20.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
20.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
20.00Consensusbombesin_offOrthosteric Ligandbb2_off
20.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.00Consensuschemerin_onOrthosteric Ligandcml1_on
20.00Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.00Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
20.00Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
20.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
20.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.00Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
20.00Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.00Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
20.00Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.00Consensuslpa_offOrthosteric Ligandlpa1_off
20.00Consensuslpa_onOrthosteric Ligandlpa1_on
20.00Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
20.00Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
20.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
20.00Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
20.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
19.35Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
19.35Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
19.23Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
19.23Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
19.23Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
19.23Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
19.23Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
19.23Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
19.23Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
19.23Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
19.23Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
19.23Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
19.05Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
19.05Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
19.05Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
19.05Single4LDEBI1671074LDE-β2-BI167107
19.05Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
19.05Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
19.05Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
19.05Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
19.05Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
19.05Single6YVRNTS8-136YVR-NTS1-NTS8-13
19.05Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
19.05Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
19.05Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
19.05Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
19.05Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
19.05Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
19.05Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
19.05Single8JJ8Formoterol8JJ8-β2-Formoterol
19.05Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
19.05Single8JWZAB9288JWZ-A2A-AB928-Na
19.05Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
19.05Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
19.05Consensuschemokine_offOrthosteric Ligandcxcr_off
19.05Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
19.05Consensuscxcr_offOrthosteric Ligandcxcr4_off
19.05Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
19.05Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
19.05Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
19.05Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
19.05Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
19.05Consensusnts_onOrthosteric Ligandnts1_on
19.05Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
19.05Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
19.05Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
18.75Single3OE9IT1t3OE9-CXCR4-IT1t
18.75Single3PBLEticlopride3PBL-D3-Eticlopride
18.75Single4O9RCyclopamine4O9R-SMO-Cyclopamine
18.75Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
18.75Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
18.75Single6HLLCP999946HLL-NK1-CP99994
18.75Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
18.75Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
18.75Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
18.75Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
18.75Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
18.75Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
18.75Single7SRQLSD7SRQ-5-HT2B-LSD
18.75Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
18.75Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
18.75Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
18.75Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
18.75Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
18.75Single8GGSEpinephrine8GGS-β2-Epinephrine
18.75Single8GGYEpinephrine8GGY-β2-Epinephrine
18.75Single8GH1Epinephrine8GH1-β2-Epinephrine
18.75Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
18.75Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
18.75Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
18.75Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
18.75Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single8K5BNiacin8K5B-HCA2-Niacin
18.75Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.75Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.75Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
18.75Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
18.75Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
18.75Consensusgo_class-b2Orthosteric Ligandgo_adhesion
18.75Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
18.75Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
18.75Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
18.52Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
18.52Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
18.52Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
18.52Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
18.52Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
18.52Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
18.52Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.18Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
18.18Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
18.18Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
18.18Single6H7LDobutamine6H7L-β1-Dobutamine
18.18Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
18.18Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
18.18Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
18.18Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
18.18Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
18.18Single7UM4AS26747237UM4-5-HT5A-AS2674723
18.18Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
18.18Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
18.18Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
18.18Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
18.18Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.18Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
18.18Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
18.18Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
18.18Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
18.18Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
18.18Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
18.18Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
18.18Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
18.18Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
17.86Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
17.86Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
17.86Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
17.86Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
17.86Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
17.86Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
17.86Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
17.86Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
17.86Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
17.65Single4QINSAG1.54QIN-SMO-SAG1.5
17.65Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
17.65Single6AKXA4R6AKX-CCR5-A4R
17.65Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
17.65Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
17.65Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
17.65Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
17.65Single6TODEMPA6TOD-OX1-EMPA-Na
17.65Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
17.65Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
17.65Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
17.65Single7F8ULintitript7F8U-CCKA-Lintitript
17.65Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
17.65Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
17.65Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
17.65Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
17.65Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
17.65Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
17.65Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
17.65Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
17.65Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
17.65Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
17.65Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
17.65Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
17.65Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.65Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.65Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.65Single8GGVEpinephrine8GGV-β2-Epinephrine
17.65Single8GGWEpinephrine8GGW-β2-Epinephrine
17.65Single8GGXEpinephrine8GGX-β2-Epinephrine
17.65Single8GH0Epinephrine8GH0-β2-Epinephrine
17.65Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single8IWESpermidine8IWE-TAAR9-Spermidine
17.65Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
17.65Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.65Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
17.65Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
17.65Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
17.65Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
17.65Consensusclass-f_offOrthosteric Ligandsmo_off
17.65Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Consensusgt_class-aOrthosteric Ligandgt_opsin
17.65Consensusgt_opsinOrthosteric Ligandgt_sensory
17.65Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
17.65Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
17.65Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
17.65Consensusmglu_onOther Ligandmglu2_on mglu4_on
17.65Consensusorexin_offOrthosteric Ligandox2_off ox1_off
17.65Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
17.39Single5EE7MK08935EE7-Glucagon-MK0893
17.39Single5ZTYAM102575ZTY-CB2-AM10257
17.39Single6PT3DPI-2876PT3-δ-DPI-287
17.39Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
17.39Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
17.39Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
17.39Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
17.39Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
17.39Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
17.39Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
17.39Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
17.39Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
17.39Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
17.39Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
17.39Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
17.39Consensuslpl_offOrthosteric Ligands1p_off lpa_off
17.39Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
17.39Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.24Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
17.24Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
17.24Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
17.24Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
17.24Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
17.24Consensusendothelin_onOrthosteric Ligandetb_on eta_on
17.24Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
17.24Consensusgo_class-b1Orthosteric Ligandgo_crf
17.24Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
17.24Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.67Single3REYPubChem 56973REY-A2A-PubChem 5697
16.67Single3RZECidoxepin3RZE-H1-Cidoxepin
16.67Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
16.67Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
16.67Single4MBSMaraviroc4MBS-CCR5-Maraviroc
16.67Single4XT1Fractalkine4XT1-US28-Fractalkine
16.67Single4ZJCSB-6740424ZJC-OX1-SB-674042
16.67Single6A94Zotepine6A94-5-HT2A-Zotepine
16.67Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
16.67Single6DS0Ly2660976DS0-5-HT2B-Ly266097
16.67Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
16.67Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
16.67Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
16.67Single6LMLGlucagon6LML-Glucagon-Glucagon
16.67Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
16.67Single6TPGEMPA6TPG-OX2-EMPA
16.67Single6TPKRetosiban6TPK-OT-Retosiban
16.67Single6TPNHTL66416TPN-OX2-HTL6641
16.67Single6V9SGTPL114036V9S-OX1-GTPL11403
16.67Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
16.67Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
16.67Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
16.67Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
16.67Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
16.67Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
16.67Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
16.67Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
16.67Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
16.67Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
16.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.67Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single7T32ZM2413857T32-A2A-ZM241385
16.67Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
16.67Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
16.67Single7VODCariprazine7VOD-5-HT2A-Cariprazine
16.67Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
16.67Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
16.67Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
16.67Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
16.67Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
16.67Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
16.67Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
16.67Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
16.67Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GGIEpinephrine8GGI-β2-Epinephrine
16.67Single8GGTEpinephrine8GGT-β2-Epinephrine
16.67Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
16.67Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
16.67Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
16.67Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
16.67Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
16.67Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
16.67Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
16.67Single8K5CAcipimox8K5C-HCA2-Acipimox
16.67Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
16.67Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
16.67Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
16.67Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
16.67Consensus5ht5_onOrthosteric Ligand5ht5a_on
16.67Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
16.67Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
16.67Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
16.67Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.67Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
16.67Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
16.67Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
16.67Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
16.67Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.67Consensusgi_class-fOrthosteric Ligandgi_frizzled
16.67Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
16.67Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
16.67Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
16.67Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
16.67Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
16.67Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
16.67Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
16.67Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
16.67Consensusvasopressin-ot_offOrthosteric Ligandot_off
16.13Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
16.13Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
16.13Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
16.00Single6HLOAprepitant6HLO-NK1-Aprepitant
16.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
16.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
16.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
16.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
16.00Single7SK5CXCL127SK5-ACKR3-CXCL12
16.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
16.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
16.00Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
15.79Single2Y04Salbutamol2Y04-β1-Salbutamol
15.79Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
15.79Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
15.79Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
15.79Single5T04Neurotensin5T04-NTS1-Neurotensin
15.79Single5TGZAM65385TGZ-CB1-AM6538
15.79Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
15.79Single6DRXLisuride6DRX-5-HT2B-Lisuride
15.79Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
15.79Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
15.79Single6H7MSalbutamol6H7M-β1-Salbutamol
15.79Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
15.79Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
15.79Single6TOTLemborexant6TOT-OX1-Lemborexant
15.79Single7BU7BI1671077BU7-β1-BI167107
15.79Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
15.79Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
15.79Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
15.79Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
15.79Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
15.79Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
15.79Single7WC7Lisuride7WC7-5-HT2A-Lisuride
15.79Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
15.79Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
15.79Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
15.79Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
15.79Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
15.79Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.79Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
15.79Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
15.79Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
15.79Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
15.79Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
15.79Single8K5DGSK2560738K5D-HCA2-GSK256073
15.79Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
15.79Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
15.79Single8X63Mepyramine8X63-H1-Mepyramine
15.79Single8X64Desloratadine8X64-H1-Desloratadine
15.79Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
15.79Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
15.79Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
15.79Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
15.79Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
15.79Consensuscck_offOrthosteric Ligandccka_off
15.79Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
15.79Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
15.79Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
15.79Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
15.79Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
15.79Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
15.79Consensustachykinin_offOrthosteric Ligandnk1_off
15.79Consensustar_onOrthosteric Ligandta1_on
15.62Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
15.62Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
15.62Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
15.62Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
15.62Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
15.62Consensusglp_onOrthosteric Ligandglp1_on glp2_on
15.62Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
15.38Single6PT2KGCHM076PT2-δ-KGCHM07
15.38Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
15.38Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
15.38Single7XNACYN1548067XNA-SST2-CYN154806
15.38Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
15.38Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
15.38Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
15.38Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
15.38Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
15.38Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
15.15Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
15.15Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
15.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
15.00Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
15.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
15.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
15.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
15.00Single5WIUNemonapride5WIU-D4-Nemonapride
15.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
15.00Single5WQCEMPA5WQC-OX2-EMPA
15.00Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
15.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
15.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
15.00Single6TP6Filorexant6TP6-OX1-Filorexant
15.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
15.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
15.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.00Single7SINNPS-21437SIN-CaS-NPS-2143
15.00Single7SINNPS-21437SIN-CaS-NPS-2143
15.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
15.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
15.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
15.00Single7WC6LSD7WC6-5-HT2A-LSD
15.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
15.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
15.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
15.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
15.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
15.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
15.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
15.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
15.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
15.00Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
15.00Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
15.00Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
15.00Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
15.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
15.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
14.81Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
14.81Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
14.81Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
14.81Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
14.81Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
14.71Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
14.71Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.71Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
14.29Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
14.29Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
14.29Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
14.29Single5TZR-5TZR-FFA1 (GPR40)-MK8666
14.29Single5V54Methiothepin5V54-5-HT1B-Methiothepin
14.29Single5V57TC1145V57-SMO-TC114
14.29Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
14.29Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
14.29Single6E59L-7607356E59-NK1-L-760735
14.29Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
14.29Single6TQ7SB-3348676TQ7-OX1-SB-334867
14.29Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
14.29Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
14.29Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
14.29Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
14.29Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
14.29Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
14.29Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
14.29Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
14.29Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
14.29Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
14.29Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
14.29Single7WC4Serotonin7WC4-5-HT2A-Serotonin
14.29Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
14.29Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
14.29Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
14.29Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
14.29Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
14.29Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
14.29Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
14.29Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
14.29Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
14.29Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
14.29Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
14.29Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
14.29Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
14.29Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
14.29Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
14.29Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
14.29Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
14.29Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
14.29Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
14.29Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
14.29Consensus5ht1_offOrthosteric Ligand5ht1b_off
14.29Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
14.29Consensusclass-c_onOther Ligandgabab_on mglu_on
14.29Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
14.29Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
14.29Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
14.29Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
14.29Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
14.29Consensushistamine_offOrthosteric Ligandh1_off
14.29Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
14.29Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
14.29Consensuspth_onOrthosteric Ligandpth1_on pth2_on
14.29Consensusrelaxin_onOrthosteric Ligandrxfp4_on
14.29Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
14.29Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
14.29Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.79Single4XT3Fractalkine4XT3-US28-Fractalkine
13.79Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
13.79Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
13.79Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
13.79Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single7SK3CXCL127SK3-ACKR3-CXCL12
13.79Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
13.79Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
13.64Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
13.64Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
13.64Single6A93Risperidone6A93-5-HT2A-Risperidone
13.64Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
13.64Single6HLPNetupitant6HLP-NK1-Netupitant
13.64Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
13.64Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
13.64Single7DFPSpiperone7DFP-D2-Spiperone
13.64Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
13.64Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
13.64Single7K15MKD0467K15-BLT1-MKD046-Na
13.64Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
13.64Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
13.64Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
13.64Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
13.64Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single7YITNalfurafine7YIT-κ-Nalfurafine
13.64Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
13.64Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
13.64Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
13.64Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
13.64Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
13.64Single8WU1KCA8WU1-CB1-KCA-Arrestin1
13.64Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
13.64Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
13.64Consensusblt_offOrthosteric Ligandblt1_off
13.64Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
13.64Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
13.64Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
13.64Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
13.64Consensusnts_offOrthosteric Ligandnts1_off
13.51Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
13.33Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
13.33Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
13.33Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
13.33Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
13.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
13.33Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
13.33Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
13.33Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.33Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
13.33Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
13.33Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
13.33Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
13.33Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
13.33Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.33Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
13.33Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
13.33Consensussensory_onOrthosteric Ligandopsin_on
13.33Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.16Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
13.04Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
13.04Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
13.04Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
13.04Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
13.04Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
13.04Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
13.04Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
13.04Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
13.04Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
13.04Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
13.04Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
13.04Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
13.04Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
13.04Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
13.04Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
13.04Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
13.04Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
13.04Consensuscyslt_offOrthosteric Ligandcyslt2_off
13.04Consensusendothelin_offOrthosteric Ligandetb_off
13.04Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
13.04Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.04Consensusorexin_onOrthosteric Ligandox2_on
12.90Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
12.90Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
12.90Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
12.90Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
12.90Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
12.82Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
12.50Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
12.50Single3OE6IT1t3OE6-CXCR4-IT1t
12.50Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
12.50Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
12.50Single6LI0GTPL98046LI0-GPR52-GTPL9804
12.50Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
12.50Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
12.50Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
12.50Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
12.50Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
12.50Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
12.50Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
12.50Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
12.50Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
12.50Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
12.50Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
12.50Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
12.50Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
12.50Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8X5YAstemizole8X5Y-H1-Astemizole
12.50Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
12.50Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
12.50Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
12.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
12.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
12.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
12.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
12.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
11.76Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
11.76Single5L7IVismodegib5L7I-SMO-Vismodegib
11.76Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
11.76Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
11.76Single6TP4ACT-4622066TP4-OX1-ACT-462206
11.76Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.76Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.76Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
11.76Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
11.76Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
11.76Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
11.76Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.76Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.76Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
11.76Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
11.76Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
11.76Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.76Consensusgo_proteinOrthosteric Ligandgo_chemokine
11.76Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
11.76Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
11.76Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
11.76Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.54Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
11.54Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
11.54Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
11.54Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
11.54Consensussst_offOrthosteric Ligandsst2_off
11.43Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
11.11Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
11.11Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
11.11Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
11.11Single3ODUIT1t3ODU-CXCR4-IT1t
11.11Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.11Single4S0VSuvorexant4S0V-OX2-Suvorexant
11.11Single5DHHSB-6121115DHH-NOP-SB-612111
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single5WS3EMPA5WS3-OX2-EMPA
11.11Single5ZKQABT-4915ZKQ-PAF-ABT-491
11.11Single6AKYMaraviroc6AKY-CCR5-Maraviroc
11.11Single6B73PubChem 1319551386B73-κ-PubChem 131955138
11.11Single6KUXRS-799486KUX-α2a-RS-79948
11.11Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
11.11Single6TPJSuvorexant6TPJ-OX2-Suvorexant
11.11Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
11.11Single6W25SHU91196W25-MC4-SHU9119-Ca
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.11Single7F8YDevazepide7F8Y-CCKA-Devazepide
11.11Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.11Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
11.11Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
11.11Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
11.11Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
11.11Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
11.11Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
11.11Single7XRRLemborexant7XRR-OX2-Lemborexant
11.11Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
11.11Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
11.11Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
11.11Single8IHKAcifran8IHK-HCA3-Acifran
11.11Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
11.11Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
11.11Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
11.11Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusalpha1_onOrthosteric Ligandalpha1a_on
11.11Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
11.11Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
11.11Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
11.11Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
10.81Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.71Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
10.71Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
10.71Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.53Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.53Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
10.53Single6FFIMMPEP6FFI-mGlu5-MMPEP
10.53Single6IQLL7458706IQL-D4-L745870
10.53Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
10.53Single6TP3Nemorexant6TP3-OX1-Nemorexant
10.53Single6VI4JDTic6VI4-κ-JDTic
10.53Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
10.53Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
10.53Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
10.53Single6ZINSR486926ZIN-NTS1-SR48692
10.53Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.53Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
10.53Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
10.53Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
10.53Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
10.53Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
10.53Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
10.53Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
10.53Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
10.53Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
10.53Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
10.53Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
10.53Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
10.53Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
10.53Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
10.53Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
10.53Consensuss1p_offOrthosteric Ligands1p1_off
10.53Consensussensory_offOrthosteric Ligandopsin_off
10.34Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
10.26Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.00Single2Y01Dobutamine2Y01-β1-Dobutamine
10.00Single4DAJTiotropium4DAJ-M3-Tiotropium
10.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
10.00Single4MQSIperoxo4MQS-M2-Iperoxo
10.00Single4U14Tiotropium4U14-M3-Tiotropium
10.00Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
10.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
10.00Single5DSGTiotropium5DSG-M4-Tiotropium
10.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
10.00Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
10.00Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
10.00Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
10.00Single6FFHFenobam6FFH-mGlu5-Fenobam
10.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
10.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
10.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
10.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
10.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
10.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
10.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
10.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
10.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
10.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
10.00Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
10.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
10.00Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.00Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
10.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
10.00Consensushistamine_onOrthosteric Ligandh1_on h4_on
10.00Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
10.00Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
10.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
10.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
10.00Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
9.52Single2Y00Dobutamine2Y00-β1-Dobutamine
9.52Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
9.52Single5CGCHTL142425CGC-mGlu5-HTL14242
9.52Single5XPRBosentan5XPR-ETB-Bosentan
9.52Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
9.52Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
9.52Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
9.52Single6Z4SSR486926Z4S-NTS1-SR48692
9.52Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
9.52Single7C4SS1P7C4S-S1P3-S1P
9.52Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
9.52Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
9.52Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
9.52Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
9.52Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
9.52Single7YXAONO-54306087YXA-S1P5-ONO-5430608
9.52Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single8EA0Iperoxo8EA0-M3-Iperoxo
9.52Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
9.52Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
9.52Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
9.52Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
9.52Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
9.52Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
9.52Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
9.52Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
9.52Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
9.52Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.38Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
9.09Single4DJHJDTic4DJH-κ-JDTic
9.09Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
9.09Single4U15Tiotropium4U15-M3-Tiotropium
9.09Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
9.09Single5X93K-87945X93-ETB-K-8794
9.09Single5XR8AM8415XR8-CB1-AM841
9.09Single5XRAAM115425XRA-CB1-AM11542
9.09Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
9.09Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
9.09Single6D35Cholesterol6D35-SMO-Cholesterol
9.09Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
9.09Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
9.09Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
9.09Single6OL9Tiotropium6OL9-M5-Tiotropium
9.09Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
9.09Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
9.09Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
9.09Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
9.09Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
9.09Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
9.09Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
9.09Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
9.09Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
9.09Single7DTTCa7DTT-CaS-Ca-Ca
9.09Single7DTTCa7DTT-CaS-Ca-Ca
9.09Single7DTUTryptophan7DTU-CaS-Tryptophan
9.09Single7DTUTryptophan7DTU-CaS-Tryptophan
9.09Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
9.09Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
9.09Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
9.09Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
9.09Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
9.09Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
9.09Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
9.09Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
9.09Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
9.09Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
9.09Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
9.09Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
9.09Single7EPENAM5637EPE-mGlu-NAM563
9.09Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
9.09Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
9.09Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
9.09Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
9.09Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
9.09Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7FIIhCG7FII-LH-hCG-6fuf
9.09Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
9.09Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
9.09Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.09Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
9.09Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
9.09Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
9.09Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
9.09Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
9.09Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
9.09Single7P2L4YI7P2L-mGlu5-4YI
9.09Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
9.09Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
9.09Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
9.09Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
9.09Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
9.09Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
9.09Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
9.09Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
9.09Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
9.09Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
9.09Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
9.09Single7XW7K1-707XW7-TSH-K1-70
9.09Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
9.09Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
9.09Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
9.09Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
9.09Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
9.09Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
9.09Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
9.09Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
9.09Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
9.09Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
9.09Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
9.09Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
9.09Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
9.09Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
9.09Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
9.09Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
9.09Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
9.09Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
9.09Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
9.09Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
9.09Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
9.09Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
9.09Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
9.09Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
9.09Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
9.09Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
9.09Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
9.09Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
9.09Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
9.09Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
9.09Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
9.09Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
9.09Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
9.09Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
9.09Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
9.09Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
9.09Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
9.09Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.09Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
9.09Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
9.09Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
9.09Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
9.09Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.09Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.09Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.09Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.09Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.09Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
9.09Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
9.09Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
9.09Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
9.09Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
9.09Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
9.09Consensusclass-c_offOther Ligandgabab_off mglu_off
9.09Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
9.09Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
9.09Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
9.09Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
9.09Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
9.09Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
9.09Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
9.09Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
9.09Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
9.09Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
9.09Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Consensusgphr_onOrthosteric Ligandlh_on tsh_on
9.09Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
9.09Consensusgs_proteinOrthosteric Ligandgs_gphr
9.09Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
9.09Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
9.09Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
9.09Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
9.09Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
9.09Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
9.09Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
9.09Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
9.09Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
9.09Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
9.09Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
9.09Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
9.09Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
9.09Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
9.09Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
9.09Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
9.09Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
9.09Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
9.09Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
9.09Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
9.09Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
9.09Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
8.82Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
8.70Single4PY02MeSATP4PY0-P2Y12-2MeSATP
8.70Single5CXVTiotropium5CXV-M1-Tiotropium
8.70Single6CM4Risperidone6CM4-D2-Risperidone
8.70Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
8.70Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
8.70Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single6ZG4HTL00099366ZG4-M1-HTL0009936
8.70Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
8.70Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
8.70Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
8.70Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
8.70Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
8.70Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.70Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
8.70Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
8.70Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
8.70Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
8.70Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
8.70Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
8.70Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
8.70Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
8.70Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
8.57Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single5CGDHTL142425CGD-mGlu5-HTL14242
8.33Single6K1QIRL25006K1Q-ETB-IRL2500
8.33Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
8.33Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
8.33Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
8.33Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
8.33Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.33Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.33Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
8.33Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
8.33Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
8.33Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
8.33Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
8.33Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
8.33Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
8.33Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
8.33Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
8.33Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single7SK9CCX6627SK9-ACKR3-CCX662
8.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
8.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Consensusclass-d_offOrthosteric Ligandste2_off
8.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
7.69Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
7.69Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
7.69Single7QA8Peptide7QA8-STE2-Peptide
7.69Single7QA8Peptide7QA8-STE2-Peptide
7.69Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
7.69Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
7.69Single8HS2Fab0468HS2-GPR20-Fab046
7.69Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
7.69Consensusclass-d_offOrthosteric Ligandste2_off
7.69Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
7.41Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
7.41Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
7.41Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
7.14Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
7.14Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
7.14Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
7.14Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
7.14Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
7.14Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
7.14Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
7.14Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
6.67Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
6.67Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
6.67Single5L7DCholesterol5L7D-SMO-Cholesterol
6.67Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
6.67Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
6.67Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.67Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
6.67Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
6.45Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
6.45Consensusclass-d_onOrthosteric Ligandste2_on
6.25Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.25Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
6.25Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.25Consensusgi_class-dOrthosteric Ligandgi_ste
6.25Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.06Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
5.88Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.88Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
5.88Single3OE8IT1t3OE8-CXCR4-IT1t
5.88Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
5.88Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
5.88Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.88Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.88Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
5.88Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.88Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
5.56Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
5.56Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
5.56Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
5.56Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
5.56Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
5.56Single7UL2SR486927UL2-NTS1-SR48692-Na
5.56Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.56Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.56Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
5.56Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.56Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.56Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.56Consensusclass-t_onOrthosteric Ligandtaste2_on
5.56Consensusgs_class-tOrthosteric Ligandgs_taste
5.56Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.56Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.56Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.56Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
5.56Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.26Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
5.26Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
5.26Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
5.26Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.26Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
5.26Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
5.26Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
5.26Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.26Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.26Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.26Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
5.26Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.26Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
5.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
5.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
5.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
5.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
5.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
5.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
5.00Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
5.00Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.00Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
5.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
4.76Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
4.76Single4YAYZD-71554YAY-AT1-ZD-7155
4.76Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
4.76Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
4.76Single6IIVDaltroban6IIV-TP-Daltroban
4.76Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
4.76Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
4.76Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
4.76Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
4.76Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
4.76Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
4.76Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.76Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
4.76Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
4.76Consensusblt_onOrthosteric Ligandblt1_on
4.76Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
4.76Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.76Consensusleuko_onOrthosteric Ligandblt_on
4.76Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
4.55Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
4.55Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
4.55Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
4.55Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.55Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
4.55Consensusep_offOrthosteric Ligandep4_off
4.35Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
4.35Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.35Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
4.17Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
4.17Single6IIURamatroban6IIU-TP-Ramatroban
4.17Single7SHEPI; PE7SHE-GPR158-PI; PE
4.17Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
4.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
4.00Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.00Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
3.70Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
3.57Single7SHEPI; PE7SHE-GPR158-PI; PE
3.57Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.45Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
2.94Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.86Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.86Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.86Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.86Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.86Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
2.78Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.70Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.70Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.63Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.63Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.50Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.38Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.33Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.22Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

Consensus Members
Id Members
8I2G 8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
Net Summary
Imin 2.94
Number of Linked Nodes 569
Number of Links 695
Number of Hubs 101
Number of Links mediated by Hubs 364
Number of Communities 17
Number of Nodes involved in Communities 162
Number of Links involved in Communities 229
Path Summary
Number Of Nodes in MetaPath 86
Number Of Links MetaPath 85
Number of Shortest Paths 852953
Length Of Smallest Path 3
Average Path Length 33.5128
Length of Longest Path 67
Minimum Path Strength 1.185
Average Path Strength 5.92147
Maximum Path Strength 23.6367
Minimum Path Correlation 0.7
Average Path Correlation 0.981243
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 51.2116
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.21
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .




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