psnGPCR

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Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R1.NT	R1.NT	3639.86	Yes	Yes	1	6	6
2	R1.Lig	R1.NT	80.6062	No	Yes	0	0	6
3	R1.NT	R2.NT	219.262	Yes	Yes	1	6	6
4	R1.E2	R1.NT	79.145	Yes	Yes	1	4	6
5	R1.E3	R1.NT	8.005	Yes	Yes	1	5	6
6	R1.E1	R1.NT	25.955	Yes	Yes	1	4	6
7	R1.7x35	R1.NT	8.38375	Yes	Yes	1	7	6
8	R1.1x36	R1.NT	2.8275	No	Yes	1	5	6
9	R1.1x35	R1.7x36	4.275	No	No	0	6	5
10	R1.1x36	R1.1x40	3.965	No	No	0	5	3
11	R1.1x38	R1.1x39	3.4675	No	No	0	4	6
12	R1.1x39	R1.7x39	4.74625	No	No	0	6	7
13	R1.1x40	R1.2x58	4.06875	No	No	0	3	5
14	R1.1x41	R1.1x45	2.56625	No	No	0	3	3
15	R1.1x42	R1.7x43	3.39	No	No	0	4	5
16	R1.1x43	R1.2x54	3.005	No	Yes	0	7	8
17	R1.1x43	R1.2x57	5.3	No	No	0	7	8
18	R1.1x43	R1.2x58	2.91375	No	No	0	7	5
19	R1.1x46	R1.2x54	4.8375	No	Yes	8	9	8
20	R1.1x46	R1.7x47	2.895	No	No	8	9	8
21	R1.1x47	R1.2x51	3.04375	No	No	0	8	6
22	R1.1x47	R1.2x54	2.66625	No	Yes	0	8	8
23	R1.1x50	R1.7x50	3.23125	No	Yes	0	7	8
24	R1.1x53	R1.7x53	8.9325	No	Yes	0	8	9
25	R1.1x54	R1.2x44	2.645	No	Yes	0	8	8
26	R1.1x54	R1.2x47	4.32125	No	No	0	8	7
27	R1.1x56	R1.7x57	4.28875	No	No	0	8	6
28	R1.1x57	R1.I1x50	3.87375	No	No	0	9	9
29	R1.1x57	R1.7x53	2.8175	No	Yes	0	9	9
30	R1.1x59	R1.1x60	3.545	No	Yes	0	2	5
31	R1.1x60	R1.I1x47	2.9	Yes	No	0	5	5
32	R1.1x60	R1.7x60	3.71	Yes	No	0	5	6
33	R1.I1	R1.I1x51	3.965	No	No	0	6	8
34	R1.I1x47	R1.I1x48	3.49625	No	No	0	5	8
35	R1.7x60	R1.I1x48	3.645	No	No	0	6	8
36	R1.7x59	R1.I1x49	14.7075	No	No	0	5	4
37	R1.7x56	R1.I1x53	4.01625	No	No	0	9	9
38	R1.2x39	R1.2x42	2.82625	No	Yes	3	9	6
39	R1.2x39	R1.I3	8.2	No	Yes	3	9	7
40	R1.2x41	R1.2x44	3.1675	No	Yes	9	5	8
41	R1.2x41	R1.4x43	8.9175	No	No	0	5	5
42	R1.2x42	R1.3x45	2.76125	Yes	No	3	6	7
43	R1.2x42	R1.3x46	4.23	Yes	Yes	3	6	9
44	R1.2x42	R1.4x42	3.1025	Yes	No	3	6	8
45	R1.2x43	R1.3x46	3.6975	No	Yes	0	9	9
46	R1.2x45	R1.3x38	3.035	No	Yes	0	6	7
47	R1.2x46	R1.3x42	5.57	Yes	No	0	7	7
48	R1.2x46	R1.3x43	3.125	Yes	No	0	7	9
49	R1.2x46	R1.7x521	3.55	Yes	No	0	7	7
50	R1.2x47	R1.7x53	5.07625	No	Yes	0	7	9
51	R1.2x50	R1.7x46	2.7625	No	No	0	5	8
52	R1.2x50	R1.7x50	3.65125	No	Yes	0	5	8
53	R1.2x54	R1.7x43	3.08	Yes	No	0	8	5
54	R1.2x54	R1.7x46	4.96625	Yes	No	0	8	8
55	R1.2x54	R1.7x47	3.07875	Yes	No	8	8	8
56	R1.2x57	R1.7x39	4.30125	No	No	0	8	7
57	R1.2x60	R1.3x28	8.44625	No	Yes	0	5	8
58	R1.2x62	R1.E1	3.355	No	Yes	0	5	4
59	R1.E1	R1.E1	8.97375	Yes	Yes	1	4	4
60	R1.E1	R1.E2	11.17	Yes	Yes	1	4	4
61	R1.3x20	R1.E1	3.985	No	Yes	0	3	4
62	R1.3x21	R1.E2	4.235	No	Yes	1	4	4
63	R1.3x24	R1.3x28	3.43125	No	Yes	0	5	8
64	R1.3x25	R1.E2	4.205	No	Yes	1	9	4
65	R1.3x25	R1.E2x50	5.46	No	No	0	9	9
66	R1.3x26	R1.3x30	5.33875	No	Yes	0	6	6
67	R1.3x26	R1.4x61	9.20625	No	No	0	6	6
68	R1.3x28	R1.E2x50	4.0025	Yes	No	0	8	9
69	R1.3x29	R1.4x57	5.535	Yes	No	0	5	8
70	R1.3x29	R1.4x60	3.22	Yes	No	0	5	9
71	R1.3x29	R1.4x61	7.23375	Yes	No	1	5	6
72	R1.3x30	R1.4x57	8.29625	Yes	No	0	6	8
73	R1.3x36	R1.3x40	5.8825	No	Yes	4	9	8
74	R1.3x36	R1.5x47	4.77625	No	Yes	4	9	9
75	R1.3x37	R1.4x50	3.00625	No	No	0	9	7
76	R1.3x37	R1.4x53	9.82875	No	Yes	0	9	9
77	R1.3x38	R1.4x50	5.04125	Yes	No	0	7	7
78	R1.3x40	R1.5x50	5.71375	Yes	No	0	8	8
79	R1.3x40	R1.5x51	6.65375	Yes	No	0	8	8
80	R1.3x40	R1.6x41	2.71875	Yes	Yes	0	8	8
81	R1.3x41	R1.4x49	2.58125	No	No	0	9	6
82	R1.3x43	R1.6x37	3.305	No	No	0	9	9
83	R1.3x43	R1.6x41	3.97375	No	Yes	0	9	8
84	R1.3x44	R1.5x50	3.4725	Yes	No	0	9	8
85	R1.3x44	R1.5x53	3.3175	Yes	No	0	9	7
86	R1.3x44	R1.5x54	2.89375	Yes	No	0	9	9
87	R1.3x44	R1.5x57	3.1	Yes	Yes	0	9	9
88	R1.3x45	R1.4x42	4.13375	No	No	3	7	8
89	R1.3x45	R1.4x45	4.685	No	No	0	7	6
90	R1.3x46	R1.I3	4.83	Yes	Yes	3	9	7
91	R1.3x46	R1.6x33	4.15	Yes	Yes	0	9	9
92	R1.3x46	R1.6x37	3.73	Yes	No	0	9	9
93	R1.3x47	R1.6x41	2.59875	No	Yes	0	9	8
94	R1.3x48	R1.5x57	6.78625	No	Yes	0	8	9
95	R1.3x49	R1.3x52	2.885	Yes	Yes	0	9	6
96	R1.3x49	R1.4x41	4.06	Yes	No	0	9	7
97	R1.3x49	R1.4x42	14.0025	Yes	No	0	9	8
98	R1.3x49	R1.4x45	3.03	Yes	No	0	9	6
99	R1.3x50	R1.5x61	3.675	No	No	0	9	9
100	R1.3x50	R1.I3	7.31375	No	Yes	3	9	7
101	R1.3x50	R1.6x34	4.75875	No	No	3	9	9
102	R1.3x51	R1.5x57	3.38125	No	Yes	0	8	9
103	R1.3x51	R1.5x60	7.595	No	No	0	8	8
104	R1.3x51	R1.5x61	2.89	No	No	0	8	9
105	R1.3x52	R1.3x53	4.23875	Yes	No	0	6	8
106	R1.3x54	R1.I3	16.4	No	Yes	3	8	7
107	R1.4x38	R1.I2	2.815	Yes	Yes	6	6	8
108	R1.4x38	R1.4x39	2.565	Yes	No	0	6	8
109	R1.4x38	R1.4x40	5.66375	Yes	No	6	6	4
110	R1.4x38	R1.4x41	5.47625	Yes	No	6	6	7
111	R1.4x40	R1.4x41	6.96	No	No	6	4	7
112	R1.4x53	R1.4x57	3.10125	Yes	No	0	9	8
113	R1.4x53	R1.5x47	5.335	Yes	Yes	4	9	9
114	R1.4x56	R1.5x43	4.54	No	No	0	6	6
115	R1.4x60	R1.5x39	10.6062	No	No	0	9	8
116	R1.4x60	R1.5x43	4.51	No	No	0	9	6
117	R1.4x61	R1.E2	8.0525	No	Yes	1	6	4
118	R1.4x63	R1.4x64	4.355	No	No	0	4	8
119	R1.4x64	R1.E2	8.1425	No	Yes	1	8	4
120	R1.4x64	R1.E2x52	3.00875	No	No	1	8	8
121	R1.E2	R1.E2	102.221	Yes	Yes	1	4	4
122	R1.E2	R1.E2x51	8.12625	Yes	Yes	1	4	5
123	R1.E2	R1.E3	7.74	Yes	Yes	1	4	5
124	R1.5x36	R1.E2x51	3.835	No	Yes	0	5	5
125	R1.5x35	R1.5x38	5.255	No	No	0	5	5
126	R1.5x36	R1.5x40	2.825	No	No	0	5	5
127	R1.5x37	R1.6x56	2.805	No	No	0	4	5
128	R1.5x40	R1.5x44	7.035	No	Yes	4	5	6
129	R1.5x46	R1.5x47	5.065	Yes	Yes	4	7	9
130	R1.5x51	R1.6x45	3.78875	No	No	0	8	7
131	R1.5x56	R1.5x57	2.72625	No	Yes	0	9	9
132	R1.5x56	R1.5x60	3.7675	No	No	0	9	8
133	R1.5x59	R1.5x62	5.45625	No	No	2	8	9
134	R1.5x59	R1.Alloh56	6.3	No	Yes	2	8	0
135	R1.5x62	R1.Alloh56	6.2	No	Yes	2	9	0
136	R1.I3	R1.I3	15.5775	Yes	Yes	3	7	7
137	R1.6x34	R1.I3	2.585	No	Yes	3	9	7
138	R1.7x59	R1.I3	5.425	No	Yes	3	5	7
139	R1.6x33	R1.7x56	5.8525	Yes	No	0	9	9
140	R1.6x40	R1.7x52	4.7975	No	No	0	8	7
141	R1.6x42	R1.6x46	5.17	Yes	No	0	9	6
142	R1.6x42	R2.6x39	3.59	Yes	Yes	2	9	6
143	R1.6x42	R2.6x43	7.3475	Yes	No	2	9	9
144	R1.6x42	R1.Alloh56	3.435	Yes	Yes	2	9	0
145	R1.6x43	R1.6x47	2.6475	No	No	0	8	7
146	R1.6x43	R1.7x48	4.9275	No	No	0	8	4
147	R1.6x43	R2.6x42	2.905	No	No	0	8	9
148	R1.6x50	R2.6x50	3.68	No	No	0	7	6
149	R1.6x51	R1.6x55	4.80375	Yes	No	0	8	7
150	R1.6x51	R1.7x41	4.9925	Yes	No	0	8	6
151	R1.6x52	R1.6x53	3.4475	No	No	0	7	6
152	R1.6x54	R1.7x37	3.845	No	No	0	6	6
153	R1.6x54	R2.6x54	3.9975	No	No	0	6	6
154	R1.6x55	R1.7x34	6.6975	No	No	0	7	5
155	R1.6x58	R1.E3	2.66	No	Yes	1	6	5
156	R1.6x58	R1.7x33	4.4975	No	No	0	6	6
157	R1.E3	R1.E3	5.545	Yes	Yes	1	5	5
158	R1.7x50	R1.7x53	5.66	Yes	Yes	0	8	9
159	R1.7x521	R1.7x53	5.835	No	Yes	0	7	9
160	R1.7x54	R1.7x55	3.5375	No	No	0	6	9
161	R2.NT	R2.NT	3587.32	Yes	Yes	1	6	6
162	R2.E2	R2.NT	75.7225	Yes	Yes	1	4	6
163	R2.7x31	R2.NT	6.64625	No	Yes	1	5	6
164	R2.E1	R2.NT	8.51625	Yes	Yes	1	5	6
165	R2.2x61	R2.NT	2.715	No	Yes	0	7	6
166	R2.7x32	R2.NT	3.8925	Yes	Yes	1	7	6
167	R2.7x35	R2.NT	3.08	No	Yes	1	7	6
168	R2.1x32	R2.1x34	3.565	No	No	0	6	3
169	R2.1x35	R2.7x32	3.375	Yes	Yes	0	5	7
170	R2.1x35	R2.7x36	3.97875	Yes	No	0	5	5
171	R2.1x36	R2.1x40	3.815	No	No	0	5	3
172	R2.1x39	R2.7x35	3.045	No	No	0	5	7
173	R2.1x39	R2.7x39	2.9875	No	No	0	5	6
174	R2.1x40	R2.2x58	4.02125	No	No	0	3	6
175	R2.1x42	R2.7x43	2.8325	No	No	0	4	6
176	R2.1x43	R2.2x57	7.2075	No	Yes	0	7	8
177	R2.1x43	R2.2x58	3.9825	No	No	0	7	6
178	R2.1x46	R2.2x54	5.97375	No	Yes	0	8	8
179	R2.1x47	R2.2x51	5.02375	No	No	0	8	5
180	R2.1x47	R2.2x54	3.6725	No	Yes	0	8	8
181	R2.1x53	R2.2x47	2.67875	Yes	No	7	7	7
182	R2.1x53	R2.7x53	6.9725	Yes	Yes	7	7	9
183	R2.1x54	R2.2x44	2.645	No	No	0	8	8
184	R2.1x54	R2.2x47	5.35375	No	No	0	8	7
185	R2.1x55	R2.1x56	2.68	No	No	0	1	6
186	R2.1x55	R2.1x59	3.1	No	No	0	1	2
187	R2.1x57	R2.2x44	2.725	No	No	0	9	8
188	R2.1x59	R2.1x60	6.51875	No	No	0	2	4
189	R2.1x60	R2.7x60	4.205	No	No	0	4	6
190	R2.I1	R2.I1	4.84	Yes	Yes	13	6	6
191	R2.2x40	R2.I1	5.25	Yes	Yes	13	9	6
192	R2.I1x52	R2.I3	3.9275	No	Yes	0	7	7
193	R2.7x56	R2.I1x53	3.4425	No	No	0	9	9
194	R2.2x39	R2.2x40	2.955	No	Yes	0	9	9
195	R2.2x39	R2.3x49	3.955	No	No	0	9	9
196	R2.2x40	R2.2x41	7.67375	Yes	No	0	9	5
197	R2.2x41	R2.4x39	4.6	No	No	0	5	8
198	R2.2x42	R2.3x46	8.8575	No	No	0	6	9
199	R2.2x42	R2.4x42	4.5725	No	No	0	6	8
200	R2.2x43	R2.3x46	3.6975	No	No	0	9	9
201	R2.2x43	R2.7x53	3.25625	No	Yes	0	9	9
202	R2.2x46	R2.7x53	3.8675	No	Yes	0	8	9
203	R2.2x47	R2.7x53	5.28125	No	Yes	7	7	9
204	R2.2x48	R2.2x49	2.725	No	Yes	0	3	9
205	R2.2x50	R2.7x50	3.18125	No	No	0	5	7
206	R2.2x52	R2.3x35	3.15625	No	No	0	5	9
207	R2.2x53	R2.7x46	3.3475	No	No	0	6	8
208	R2.2x54	R2.7x46	5.5125	Yes	No	0	8	8
209	R2.2x54	R2.7x47	4.73625	Yes	No	0	8	8
210	R2.2x56	R2.2x60	2.91375	No	No	0	8	5
211	R2.2x56	R2.3x32	5.9075	No	No	0	8	7
212	R2.2x57	R2.7x39	4.28125	Yes	No	0	8	6
213	R2.2x57	R2.7x42	3.68	Yes	No	0	8	8
214	R2.2x59	R2.3x27	3.355	No	No	11	6	6
215	R2.2x59	R2.3x28	3.81	No	Yes	0	6	7
216	R2.2x59	R2.3x31	2.8475	No	No	11	6	4
217	R2.2x60	R2.3x28	14.2788	No	Yes	0	5	7
218	R2.2x60	R2.7x38	3.70875	No	No	0	5	4
219	R2.E1	R2.E1	17.48	Yes	Yes	1	5	5
220	R2.E1	R2.E2	3.37125	Yes	Yes	1	5	4
221	R2.3x24	R2.E1	3.1	No	Yes	1	4	5
222	R2.3x18	R2.E2	4.125	No	Yes	0	1	4
223	R2.3x22	R2.E2	3.19875	No	Yes	1	3	4
224	R2.3x25	R2.3x28	3.135	No	Yes	0	9	7
225	R2.3x25	R2.E2x50	7.0525	No	No	0	9	9
226	R2.3x28	R2.3x29	3.97625	Yes	No	0	7	4
227	R2.3x29	R2.4x60	5.35375	No	Yes	0	4	9
228	R2.3x30	R2.4x57	3.40375	No	No	0	6	7
229	R2.3x36	R2.3x40	6.0625	Yes	Yes	5	9	8
230	R2.3x36	R2.5x47	7.92875	Yes	Yes	5	9	9
231	R2.3x36	R2.5x51	2.995	Yes	Yes	5	9	8
232	R2.3x37	R2.4x53	6.14	No	No	0	8	9
233	R2.3x38	R2.4x50	6.885	No	No	0	7	5
234	R2.3x40	R2.3x44	4.5875	Yes	No	0	8	9
235	R2.3x40	R2.5x50	4.12625	Yes	No	5	8	8
236	R2.3x40	R2.5x51	5.18875	Yes	Yes	5	8	8
237	R2.3x40	R2.6x44	5.6825	Yes	No	5	8	9
238	R2.3x40	R2.7x49	3.245	Yes	No	0	8	8
239	R2.3x41	R2.4x49	2.7025	No	No	0	9	6
240	R2.3x44	R2.5x54	5.90375	No	No	0	9	9
241	R2.3x47	R2.5x57	4.7075	No	No	0	9	9
242	R2.3x48	R2.5x57	4.3	No	No	0	8	9
243	R2.3x49	R2.4x42	7.93125	No	No	0	9	8
244	R2.3x50	R2.3x54	3.935	No	No	2	9	7
245	R2.3x50	R2.I3	4.115	No	Yes	2	9	7
246	R2.3x51	R2.3x55	10.0075	No	No	0	8	7
247	R2.3x51	R2.5x60	4.27	No	No	0	8	9
248	R2.3x51	R2.5x61	2.89	No	No	0	8	9
249	R2.3x53	R2.I2	2.945	No	Yes	12	8	5
250	R2.3x54	R2.5x64	5.42	No	No	2	7	8
251	R2.3x54	R2.I3	3.1875	No	Yes	2	7	7
252	R2.3x55	R2.I2	9.095	No	Yes	12	7	5
253	R2.I2	R2.I2	6.52	Yes	Yes	12	5	5
254	R2.4x41	R2.I2	10.11	No	Yes	0	6	5
255	R2.4x38	R2.4x39	3.41	No	No	0	6	8
256	R2.4x52	R2.5x46	2.60125	No	Yes	0	6	5
257	R2.4x53	R2.5x46	6.10375	No	Yes	0	9	5
258	R2.4x60	R2.5x36	2.9425	Yes	No	0	9	5
259	R2.4x60	R2.5x39	19.9575	Yes	No	0	9	8
260	R2.4x63	R2.4x64	3.44625	No	Yes	0	4	9
261	R2.4x64	R2.E2	5.655	Yes	Yes	1	9	4
262	R2.4x64	R2.E2x52	3.51875	Yes	Yes	1	9	8
263	R2.4x64	R2.5x39	3.50875	Yes	No	0	9	8
264	R2.E2	R2.E2	100.156	Yes	Yes	1	4	4
265	R2.E2	R2.E2x50	2.89375	Yes	No	1	4	9
266	R2.E2	R2.E2x51	15.8138	Yes	No	1	4	4
267	R2.7x31	R2.E2	8.31625	No	Yes	1	5	4
268	R2.E2x51	R2.E3	4.07	No	No	0	4	4
269	R2.E2	R2.E2x52	2.91	Yes	Yes	1	4	8
270	R2.5x36	R2.E2x52	4.205	No	Yes	0	5	8
271	R2.5x35	R2.E2	2.74	No	Yes	1	4	4
272	R2.5x40	R2.5x44	6.59625	No	No	0	5	6
273	R2.5x40	R2.6x56	3.655	No	No	0	5	5
274	R2.5x44	R2.5x47	3.14	No	Yes	0	6	9
275	R2.5x44	R2.6x52	3.01625	No	No	0	6	6
276	R2.5x46	R2.5x50	3.51625	Yes	No	5	5	8
277	R2.5x51	R2.6x41	3.36875	Yes	Yes	0	8	9
278	R2.5x51	R2.6x44	3.405	Yes	No	5	8	9
279	R2.5x55	R2.6x41	2.7375	No	Yes	0	5	9
280	R2.5x64	R2.I3	3.315	No	Yes	2	8	7
281	R2.I3	R2.I3	12.0662	Yes	Yes	2	7	7
282	R1.Alloh56	R2.6x35	8.955	Yes	No	2	0	8
283	R2.6x36	R2.7x55	7.24	No	No	0	6	9
284	R1.Alloh56	R2.6x36	4.01	Yes	No	0	0	6
285	R2.6x39	R2.6x43	2.805	Yes	No	2	6	9
286	R1.Alloh56	R2.6x39	3.455	Yes	Yes	2	0	6
287	R2.6x43	R2.7x48	2.89125	No	No	0	9	4
288	R2.6x47	R2.7x41	3.23875	Yes	No	0	7	5
289	R2.6x47	R2.7x44	6.44875	Yes	No	0	7	4
290	R2.6x47	R2.7x45	2.79875	Yes	No	0	7	7
291	R2.6x48	R2.7x45	2.765	Yes	No	0	7	7
292	R2.6x51	R2.7x41	5.3775	No	No	0	7	5
293	R2.6x54	R2.7x37	4.78	No	No	0	6	5
294	R2.6x55	R2.7x34	7.88625	No	No	0	7	5
295	R2.6x58	R2.7x33	3.53625	No	Yes	0	6	6
296	R2.7x30	R2.E3	2.61	Yes	No	0	5	4
297	R2.7x30	R2.7x33	3.79375	Yes	Yes	0	5	6
298	R2.7x44	R2.7x48	3.14	No	No	0	4	4
299	R2.7x521	R2.7x53	3.68625	No	Yes	0	8	9
300	R2.7x54	R2.7x55	3.49	No	No	0	6	9
301	R1.7x32	R1.NT	3.8975	No	Yes	1	0	6
302	R1.1x57	R1.7x56	3.5675	No	No	0	9	9
303	R1.2x40	R1.I1	2.5625	No	No	0	9	6
304	R1.2x40	R1.2x41	2.9075	No	No	9	9	5
305	R1.2x40	R1.2x44	6.945	No	Yes	9	9	8
306	R1.3x21	R1.3x24	3.94375	No	No	0	4	5
307	R1.3x29	R1.E2x51	3.61625	Yes	Yes	1	5	5
308	R1.3x29	R1.E2x52	2.75625	Yes	No	1	5	8
309	R1.3x36	R1.Allo1	3.73625	No	Yes	4	9	0
310	R1.3x40	R1.5x47	3.04375	Yes	Yes	4	8	9
311	R1.3x52	R1.I2	6.0675	Yes	Yes	6	6	8
312	R1.3x54	R1.5x64	2.7925	No	No	0	8	0
313	R1.3x56	R1.I2	2.81375	No	Yes	6	0	8
314	R1.I2	R1.I2	8.485	Yes	Yes	6	8	8
315	R1.4x53	R1.5x46	6.19875	Yes	Yes	4	9	7
316	R1.7x31	R1.E2	6.175	No	Yes	0	0	4
317	R1.E2x51	R1.E2x52	2.90125	Yes	No	1	5	8
318	R1.5x40	R1.Allo1	3.0825	No	Yes	4	5	0
319	R1.5x44	R1.Allo1	2.59375	Yes	Yes	4	6	0
320	R1.5x47	R1.Allo1	2.57625	Yes	Yes	4	9	0
321	R1.6x39	R2.6x39	5.4925	No	Yes	0	7	6
322	R1.6x48	R1.6x51	2.63	No	Yes	0	8	8
323	R1.6x55	R1.Allo1	2.64	No	Yes	0	7	0
324	R1.7x30	R1.7x33	2.5475	No	No	0	0	6
325	R2.Lig	R2.NT	39.5487	No	Yes	0	0	6
326	R2.1x35	R2.7x33	2.6825	Yes	Yes	0	5	6
327	R2.1x50	R2.2x50	2.71	No	No	10	7	5
328	R2.1x50	R2.2x54	2.6525	No	Yes	10	7	8
329	R2.1x52	R2.1x56	3.0975	No	No	0	1	6
330	R2.1x57	R2.7x56	3.7225	No	No	7	9	9
331	R2.I1x47	R2.I1x48	2.625	No	No	0	5	8
332	R2.2x41	R2.4x43	3.0075	No	No	0	5	5
333	R2.2x50	R2.2x54	3.21875	No	Yes	10	5	8
334	R2.3x29	R2.E2x52	2.945	No	Yes	0	4	8
335	R2.3x34	R2.4x54	3.6675	No	No	0	6	4
336	R2.3x36	R2.6x48	2.88125	Yes	Yes	5	9	7
337	R2.3x52	R2.I2	2.8525	No	Yes	0	6	5
338	R2.4x61	R2.E2	4.70375	No	Yes	1	6	4
339	R2.5x47	R2.6x48	3.68	Yes	Yes	5	9	7
340	R2.5x53	R2.5x57	2.89875	No	No	0	7	9
341	R2.5x54	R2.6x41	3.4425	No	Yes	0	9	9
342	R2.5x56	R2.5x60	2.9825	No	No	0	9	9
343	R2.5x59	R2.5x62	2.805	No	No	0	8	9
344	R2.6x33	R2.I3	2.77	No	Yes	2	9	7
345	R2.6x32	R2.6x35	2.6225	No	No	0	0	8
346	R2.7x31	R2.7x32	2.5875	No	Yes	1	5	7
347	R2.7x58	R2.7x62	3.6175	No	No	0	3	0
348	R1.1x34	R1.1x35	3.2025	No	No	0	3	6
349	R1.3x22	R1.E2	4.1525	No	Yes	1	3	4
350	R1.3x40	R1.6x48	2.7725	Yes	No	0	8	8
351	R1.7x32	R1.E2	2.7625	No	Yes	1	0	4
352	R2.1x57	R2.7x53	2.59875	No	Yes	7	9	9
353	R2.3x21	R2.3x24	2.57125	No	No	0	4	4
354	R2.5x37	R2.E2	4.02	No	Yes	1	4	4
355	R2.7x53	R2.7x56	4.2025	Yes	No	7	9	9
356	R1.2x52	R1.3x31	4.5675	No	No	0	6	5
357	R1.3x52	R1.3x56	2.6275	Yes	No	6	6	0
358	R1.3x58	R1.3x59	2.785	No	No	0	0	0
359	R1.7x35	R1.E2	3.755	Yes	Yes	1	7	4
360	R1.I3	R2.7x58	3.8575	Yes	No	3	7	3
361	R1.6x60	R2.E3	2.61	No	No	0	0	4
362	R1.6x61	R1.7x30	3.4425	No	No	0	0	0
363	R2.1x37	R2.1x41	3.2775	No	No	0	4	3
364	R2.3x27	R2.3x31	5.48	No	No	11	6	4
365	R2.3x40	R2.5x46	4.965	Yes	Yes	5	8	5
366	R2.7x32	R2.E2	4.9225	Yes	Yes	1	7	4
367	R2.6x35	R2.I3	4.9825	No	Yes	2	8	7
368	R2.7x30	R2.7x34	3.73	Yes	No	0	5	5
369	R1.2x59	R1.3x28	2.5175	No	Yes	0	6	8
370	R2.5x51	R2.6x45	2.5	Yes	No	0	8	5
371	R2.7x50	R2.7x53	2.4975	No	Yes	0	7	9
372	R2.1x49	R2.1x53	2.49	No	Yes	0	4	7
373	R2.5x62	R2.5x63	2.47625	No	No	0	9	7
374	R1.2x52	R1.3x35	2.465	No	No	0	6	9
375	R2.6x40	R2.7x52	2.4425	No	No	0	8	7
376	R1.1x35	R1.7x35	2.435	No	Yes	0	6	7
377	R2.I1	R2.I1x51	2.43125	Yes	No	0	6	8
378	R1.6x51	R1.7x37	2.43	Yes	No	0	8	6
379	R1.5x38	R1.5x39	2.425	No	No	0	5	8
380	R1.6x44	R1.7x45	2.41	No	No	0	8	7
381	R2.3x41	R2.4x46	2.405	No	No	0	9	7
382	R1.6x50	R2.6x47	2.3875	No	Yes	0	7	7
383	R2.1x56	R2.7x57	2.38375	No	No	0	6	5
384	R2.3x45	R2.4x42	2.38375	No	No	0	7	8
385	R1.7x30	R2.6x60	2.3725	No	No	0	0	0
386	R1.3x30	R1.4x54	2.37	Yes	No	0	6	4
387	R2.3x41	R2.4x50	2.36	No	No	0	9	5
388	R1.3x32	R1.3x33	2.35125	No	No	0	8	6
389	R2.5x39	R2.5x42	2.35	No	No	0	8	4
390	R2.7x60	R2.I1x50	2.3325	No	No	0	6	8
391	R1.1x56	R1.1x60	2.32875	No	Yes	0	8	5
392	R1.2x57	R1.7x42	2.32875	No	No	0	8	7
393	R2.6x40	R2.6x41	2.31625	No	Yes	0	8	9
394	R1.2x45	R1.4x46	2.3075	No	No	0	6	7
395	R1.7x53	R1.7x57	2.295	Yes	No	0	9	6
396	R1.6x40	R1.7x49	2.27875	No	No	0	8	8
397	R1.1x52	R1.1x56	2.2775	No	No	0	1	8
398	R2.5x43	R2.5x47	2.275	No	Yes	0	5	9
399	R1.1x49	R1.7x50	2.2725	No	Yes	0	4	8
400	R1.2x61	R1.7x35	2.26	No	Yes	0	8	7
401	R1.3x47	R1.5x58	2.255	No	No	0	9	9
402	R2.2x49	R2.3x38	2.2525	Yes	No	0	9	7
403	R2.2x62	R2.E1	2.235	No	Yes	0	5	5
404	R1.2x59	R1.3x27	2.22625	No	No	0	6	5
405	R1.2x49	R1.3x38	2.215	No	Yes	0	9	7
406	R2.3x37	R2.4x50	2.21	No	No	0	8	5
407	R2.6x40	R2.7x521	2.21	No	No	0	8	8
408	R2.2x42	R2.3x42	2.2025	No	No	0	6	7
409	R2.2x45	R2.3x42	2.2025	No	No	0	5	7
410	R2.2x40	R2.I1x49	2.1925	Yes	No	0	9	4
411	R1.6x57	R2.7x33	2.175	No	Yes	0	6	6
412	R1.6x59	R1.7x34	2.165	No	No	0	0	5
413	R1.3x34	R1.3x38	2.1575	No	Yes	0	5	7
414	R1.3x28	R1.3x32	2.125	Yes	No	0	8	8
415	R1.4x48	R1.4x52	2.12	No	No	0	4	6
416	R1.6x56	R2.1x35	2.11625	No	Yes	0	5	5
417	R2.3x26	R2.4x61	2.1075	No	No	0	5	6
418	R2.4x56	R2.4x59	2.095	No	No	0	6	4
419	R2.5x59	R2.6x42	2.06875	No	No	0	8	9
420	R2.4x52	R2.4x55	2.0625	No	No	0	6	3
421	R2.3x33	R2.4x53	2.06125	No	No	0	7	9
422	R1.2x46	R1.3x39	2.05625	Yes	No	0	7	7
423	R1.5x55	R1.6x45	2.0475	No	No	0	6	7
424	R2.3x56	R2.I2	2.045	No	Yes	0	0	5
425	R2.1x43	R2.2x54	2.04125	No	Yes	0	7	8
426	R1.1x41	R1.1x44	2.0375	No	No	0	3	3
427	R1.2x50	R1.7x49	2.035	No	No	0	5	8
428	R2.4x57	R2.4x60	2.01625	No	Yes	0	7	9
429	R2.3x45	R2.4x45	2.005	No	No	0	7	5
430	R2.5x56	R2.5x59	2.005	No	No	0	9	8
431	R2.7x36	R2.7x40	1.9825	No	No	0	5	4
432	R2.4x47	R2.4x51	1.9825	No	No	0	1	2
433	R1.6x47	R2.6x46	1.9775	No	No	0	7	6
434	R1.6x38	R1.6x41	1.97125	No	Yes	0	7	8
435	R1.7x40	R1.7x44	1.965	No	No	0	3	5
436	R1.5x44	R1.5x48	1.95375	Yes	No	0	6	7
437	R2.3x43	R2.6x41	1.94375	No	Yes	0	8	9
438	R2.6x33	R2.6x37	1.895	No	No	0	9	8
439	R1.6x31	R1.6x33	1.895	No	Yes	0	0	9
440	R2.3x49	R2.3x53	1.88	No	No	0	9	8
441	R2.7x59	R2.I1x49	1.85875	No	No	0	4	4
442	R1.5x44	R1.6x52	1.85375	Yes	No	0	6	7
443	R1.7x54	R1.7x58	1.8525	No	No	0	6	3
444	R2.5x58	R2.6x37	1.8275	No	No	0	9	8
445	R2.1x60	R2.I1x47	1.80375	No	No	0	4	5
446	R1.7x60	R1.7x61	1.78125	No	No	0	6	4
447	R2.6x37	R2.6x38	1.76125	No	No	0	8	7
448	R1.I1x49	R1.I1x52	1.745	No	No	0	4	8
449	R2.1x45	R2.1x46	1.7425	No	No	0	2	8
450	R2.2x51	R2.2x55	1.74	No	No	0	5	2
451	R1.2x59	R1.3x31	1.7325	No	No	0	6	5
452	R1.2x60	R1.7x38	1.72375	No	No	0	5	5
453	R2.3x44	R2.3x48	1.715	No	No	0	9	8
454	R2.2x49	R2.2x52	1.71	Yes	No	0	9	5
455	R1.6x33	R1.6x36	1.69125	Yes	No	0	9	6
456	R1.1x44	R1.2x58	1.68	No	No	0	3	5
457	R1.6x32	R1.6x33	1.64375	No	Yes	0	0	9
458	R2.3x17	R2.3x20	1.6	No	No	0	6	2
459	R2.2x57	R2.7x43	1.6	Yes	No	0	8	6
460	R2.7x62	R2.7x63	1.59	No	No	0	0	0
461	R2.3x20	R2.E1	1.585	No	Yes	1	2	5
462	R1.2x51	R1.2x55	1.57125	No	No	0	6	3
463	R2.5x49	R2.5x53	1.56625	No	No	0	5	7
464	R2.3x34	R2.3x35	1.5575	No	No	0	6	9
465	R1.2x56	R1.2x60	1.555	No	No	0	8	5
466	R1.7x54	R1.7x57	1.52	No	No	0	6	6
467	R1.6x44	R1.6x48	1.5175	No	No	0	8	8
468	R2.4x46	R2.4x47	1.515	No	No	0	7	1
469	R1.2x48	R1.3x38	1.49	No	Yes	0	4	7
470	R2.1x32	R2.7x32	1.49	No	Yes	0	6	7
471	R1.3x30	R1.4x58	1.48125	Yes	No	0	6	4
472	R2.7x59	R2.7x60	1.475	No	No	0	4	6
473	R2.4x56	R2.5x42	1.47	No	No	0	6	4
474	R2.2x49	R2.3x39	1.465	Yes	No	0	9	7
475	R1.1x34	R1.1x37	1.455	No	No	0	3	3
476	R2.1x44	R2.2x58	1.43	No	No	0	1	6
477	R2.1x38	R2.1x39	1.425	No	No	0	3	5
478	R2.5x37	R2.5x41	1.4	No	No	0	4	4
479	R2.1x53	R2.7x51	1.395	Yes	No	0	7	4
480	R1.5x52	R1.6x49	1.385	No	No	0	4	4
481	R1.6x58	R2.6x57	1.385	No	No	0	6	6
482	R1.5x49	R1.5x53	1.3825	No	No	0	6	7
483	R1.4x52	R1.5x46	1.37625	No	Yes	0	6	7
484	R1.5x37	R1.5x41	1.3575	No	No	0	4	4
485	R1.6x47	R1.7x44	1.355	No	No	0	7	5
486	R2.1x33	R2.NT	1.34	No	Yes	0	1	6
487	R2.5x35	R2.5x38	1.325	No	No	0	4	5
488	R2.5x62	R2.6x34	1.32	No	No	0	9	9
489	R1.4x40	R1.4x44	1.295	No	No	0	4	4
490	R1.1x58	R1.2x44	1.26125	No	Yes	0	6	8
491	R2.6x52	R2.6x53	1.2575	No	No	0	6	5
492	R2.1x37	R2.1x38	1.235	No	No	0	4	3
493	R1.2x53	R1.3x35	1.1675	No	No	0	7	9
494	R1.5x44	R1.5x45	1.1525	Yes	No	0	6	4
495	R2.6x61	R2.7x30	1.1475	No	Yes	0	0	5
496	R1.7x51	R1.7x53	1.12875	No	Yes	0	5	9
497	R1.4x46	R1.4x47	1.11875	No	No	0	7	1
498	R1.8x49	R1.I1x49	1.10875	No	No	0	0	4
499	R1.3x41	R1.4x46	1.075	No	No	0	9	7
500	R2.1x51	R2.2x51	1.0675	No	No	0	3	5
501	R1.3x54	R1.3x55	1.06375	No	No	0	8	0
502	R2.4x47	R2.4x48	1.055	No	No	0	1	3
503	R1.7x58	R1.7x62	0.99	No	No	0	3	4
504	R2.1x54	R2.1x58	0.95875	No	No	0	8	6
505	R2.6x31	R2.7x59	0.9425	No	No	0	0	4
506	R1.6x35	R1.6x39	0.93	No	No	0	8	7
507	R2.5x48	R2.6x48	0.9025	No	Yes	0	8	7
508	R1.5x48	R1.6x49	0.855	No	No	0	7	4
509	R2.4x38	R2.4x40	0.855	No	No	0	6	4
510	R1.3x60	R1.I2	0.855	No	Yes	0	0	8
511	R2.3x22	R2.3x23	0.855	No	No	0	3	1
512	R2.4x58	R2.4x62	0.8275	No	No	0	4	3
513	R1.1x51	R1.1x55	0.81	No	No	0	4	3
514	R1.4x59	R1.4x63	0.77	No	No	0	5	4
515	R2.4x44	R2.4x45	0.77	No	No	0	4	5
516	R2.3x17	R2.3x19	0.765	No	No	0	6	1
517	R2.7x57	R2.7x61	0.745	No	No	0	5	3
518	R1.8x51	R1.I3	0.73875	No	Yes	0	0	7
519	R2.6x59	R2.7x34	0.7225	No	No	0	0	5
520	R1.1x47	R1.1x51	0.7125	No	No	0	8	4
521	R2.4x58	R2.4x61	0.685	No	No	0	4	6
522	R1.5x42	R1.5x46	0.6725	No	Yes	0	4	7
523	R1.5x63	R2.7x58	0.655	No	No	0	0	3
524	R1.1x33	R1.NT	0.62125	No	Yes	0	0	6
525	R1.1x32	R1.NT	0.6175	No	Yes	0	0	6
526	R1.4x55	R1.4x56	0.60625	No	No	0	4	6
527	R1.8x53	R1.8x54	0.56375	No	No	0	0	0
528	R1.8x47	R1.8x48	0.50875	No	No	0	0	0
529	R2.5x42	R2.5x45	0.4875	No	No	0	4	4
530	R1.3x22	R1.3x23	0.4275	No	No	0	3	1
531	R1.3x56	R1.3x57	0.41	No	No	0	0	0
532	R2.5x52	R2.5x56	0.4	No	No	0	5	9
533	R1.8x52	R1.8x54	0.33	No	No	0	0	0
534	R1.4x51	R1.4x52	0.2325	No	No	0	3	6
535	R1.4x62	R1.4x63	0.2	No	No	0	4	4
536	R1.7x63	R1.8x46	0.1975	No	No	0	0	0
537	R2.7x63	R2.8x46	0.1975	No	No	0	0	0
538	R2.7x63	R2.8x48	0.17	No	No	0	0	0
539	R1.7x58	R1.7x63	0.155	No	No	0	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg. Int. Strength	Num. Of Links	Community	ConSurf
1	R1.NT	642.42	12	1	6
2	R1.1x60	3.12094	4	0	5
3	R1.2x42	3.23	4	3	6
4	R1.2x44	3.50469	4	9	8
5	R1.2x46	3.57531	4	0	7
6	R1.2x54	3.60563	6	8	8
7	R1.E1	10.4021	6	1	4
8	R1.3x28	4.1045	5	0	8
9	R1.3x29	4.47225	5	1	5
10	R1.3x30	4.37156	4	0	6
11	R1.3x38	2.78775	5	0	7
12	R1.3x40	4.46417	6	4	8
13	R1.3x44	3.19594	4	0	9
14	R1.3x46	4.1275	5	3	9
15	R1.3x49	5.99438	4	0	9
16	R1.3x52	3.95469	4	6	6
17	R1.I2	4.92021	6	6	8
18	R1.4x38	4.13	4	6	6
19	R1.4x53	6.11594	4	4	9
20	R1.E2	25.1503	14	1	4
21	R1.E2x51	4.61969	4	1	5
22	R1.5x44	2.91775	5	4	6
23	R1.5x46	3.32812	4	4	7
24	R1.5x47	4.15925	5	4	9
25	R1.5x57	3.99844	4	0	9
26	R1.I3	8.0505	10	3	7
27	R1.6x33	3.0465	5	0	9
28	R1.6x41	2.81562	4	0	8
29	R1.6x42	4.88562	4	2	9
30	R1.6x51	3.71406	4	0	8
31	R1.E3	5.899	5	1	5
32	R1.7x35	4.20844	4	1	7
33	R1.7x50	3.70375	4	0	8
34	R1.7x53	4.535	7	0	9
35	R2.NT	685.032	11	1	6
36	R2.1x35	3.03813	4	0	5
37	R2.1x53	3.38406	4	7	7
38	R2.I1	4.34031	4	13	6
39	R2.2x40	4.51781	4	13	9
40	R2.2x49	2.03813	4	0	9
41	R2.2x54	3.9725	7	10	8
42	R2.2x57	4.19219	4	0	8
43	R2.E1	7.68107	7	1	5
44	R2.3x28	6.3	4	0	7
45	R2.3x36	4.96688	4	5	9
46	R2.3x40	4.83679	7	5	8
47	R2.I2	5.72679	7	12	5
48	R2.4x60	7.5675	4	0	9
49	R2.4x64	4.03219	4	1	9
50	R2.E2	22.5803	15	1	4
51	R2.E2x52	3.39469	4	1	8
52	R2.5x46	4.29656	4	5	5
53	R2.5x47	4.25594	4	5	9
54	R2.5x51	3.4915	5	5	8
55	R2.I3	5.80375	8	2	7
56	R2.6x39	3.83563	4	2	6
57	R2.6x41	2.76175	5	0	9
58	R2.6x47	3.71844	4	0	7
59	R2.6x48	2.55719	4	5	7
60	R2.7x30	2.82031	4	0	5
61	R2.7x32	3.2535	5	1	7
62	R2.7x33	3.04688	4	0	6
63	R2.7x53	4.04531	8	7	9
64	R1.Alloh56	5.3925	6	2	0
65	R1.Allo1	2.92575	5	4	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R1.1x36	R1.1x40	17.8294	3.965	No	No	0	5	3
2	R1.1x36	R1.NT	18.2499	2.8275	No	Yes	1	5	6
3	R1.1x43	R1.2x58	16.3851	2.91375	No	No	0	7	5
4	R1.1x40	R1.2x58	17.5281	4.06875	No	No	0	3	5
5	R1.1x43	R1.2x54	15.0259	3.005	No	Yes	0	7	8
6	R1.2x50	R1.7x50	11.9751	3.65125	No	Yes	0	5	8
7	R1.2x50	R1.7x46	12.6384	2.7625	No	No	0	5	8
8	R1.2x54	R1.7x46	12.8124	4.96625	Yes	No	0	8	8
9	R1.7x50	R1.7x53	11.5332	5.66	Yes	Yes	0	8	9
10	R1.3x46	R1.I3	19.4773	4.83	Yes	Yes	3	9	7
11	R1.3x46	R1.6x37	42.2594	3.73	Yes	No	0	9	9
12	R1.3x43	R1.6x37	43.3232	3.305	No	No	0	9	9
13	R1.3x43	R1.6x41	50.4523	3.97375	No	Yes	0	9	8
14	R1.3x40	R1.6x41	54.37	2.71875	Yes	Yes	0	8	8
15	R1.3x36	R1.3x40	18.264	5.8825	No	Yes	4	9	8
16	R1.3x36	R1.Allo1	18.4431	3.73625	No	Yes	4	9	0
17	R1.5x40	R1.Allo1	38.6127	3.0825	No	Yes	4	5	0
18	R1.5x36	R1.5x40	40.6678	2.825	No	No	0	5	5
19	R1.5x36	R1.E2x51	40.7751	3.835	No	Yes	0	5	5
20	R1.E2	R1.E2x51	65.0725	8.12625	Yes	Yes	1	4	5
21	R1.E2	R1.NT	86.5805	79.145	Yes	Yes	1	4	6
22	R1.3x40	R1.5x47	55.5301	3.04375	Yes	Yes	4	8	9
23	R1.5x47	R1.Allo1	18.8059	2.57625	Yes	Yes	4	9	0
24	R1.4x53	R1.5x47	37.6503	5.335	Yes	Yes	4	9	9
25	R1.4x53	R1.4x57	45.5952	3.10125	Yes	No	0	9	8
26	R1.3x29	R1.4x57	45.6063	5.535	Yes	No	0	5	8
27	R1.3x29	R1.E2x51	24.3937	3.61625	Yes	Yes	1	5	5
28	R1.3x29	R1.4x61	24.2738	7.23375	Yes	No	1	5	6
29	R1.4x61	R1.E2	25.5056	8.0525	No	Yes	1	6	4
30	R1.2x42	R1.3x46	18.8518	4.23	Yes	Yes	3	6	9
31	R1.2x42	R1.4x42	14.6232	3.1025	Yes	No	3	6	8
32	R1.3x40	R1.5x50	14.2819	5.71375	Yes	No	0	8	8
33	R1.3x44	R1.5x50	13.1633	3.4725	Yes	No	0	9	8
34	R1.3x49	R1.4x42	13.4898	14.0025	Yes	No	0	9	8
35	R1.NT	R2.NT	100	219.262	Yes	Yes	1	6	6
36	R1.6x42	R2.6x43	10.1377	7.3475	Yes	No	2	9	9
37	R2.6x43	R2.7x48	21.2718	2.89125	No	No	0	9	4
38	R2.7x44	R2.7x48	21.7826	3.14	No	No	0	4	4
39	R2.6x47	R2.7x44	22.2912	6.44875	Yes	No	0	7	4
40	R2.6x47	R2.7x45	24.7557	2.79875	Yes	No	0	7	7
41	R2.6x48	R2.7x45	25.2561	2.765	Yes	No	0	7	7
42	R2.3x36	R2.6x48	25.9935	2.88125	Yes	Yes	5	9	7
43	R2.3x36	R2.5x51	28.8052	2.995	Yes	Yes	5	9	8
44	R2.5x51	R2.6x41	42.2105	3.36875	Yes	Yes	0	8	9
45	R2.6x40	R2.6x41	46.9662	2.31625	No	Yes	0	8	9
46	R2.6x40	R2.7x521	47.8205	2.21	No	No	0	8	8
47	R2.7x521	R2.7x53	48.2455	3.68625	No	Yes	0	8	9
48	R2.7x50	R2.7x53	73.2099	2.4975	No	Yes	0	7	9
49	R2.2x50	R2.7x50	73.5342	3.18125	No	No	0	5	7
50	R2.2x50	R2.2x54	73.7333	3.21875	No	Yes	10	5	8
51	R2.1x43	R2.2x54	77.3097	2.04125	No	Yes	0	7	8
52	R2.1x43	R2.2x57	78.82	7.2075	No	Yes	0	7	8
53	R2.2x57	R2.7x39	80.0015	4.28125	Yes	No	0	8	6
54	R2.1x39	R2.7x39	80.2932	2.9875	No	No	0	5	6
55	R2.1x39	R2.7x35	81.4451	3.045	No	No	0	5	7
56	R2.7x35	R2.NT	81.7293	3.08	No	Yes	1	7	6
57	R2.6x39	R2.6x43	10.6189	2.805	Yes	No	2	6	9
58	R2.3x53	R2.I2	11.5369	2.945	No	Yes	12	8	5
59	R2.3x49	R2.3x53	12.0743	1.88	No	No	0	9	8
60	R2.3x49	R2.4x42	24.4618	7.93125	No	No	0	9	8
61	R2.2x42	R2.4x42	26.4547	4.5725	No	No	0	6	8
62	R2.2x42	R2.3x46	27.9338	8.8575	No	No	0	6	9
63	R2.2x43	R2.3x46	28.4239	3.6975	No	No	0	9	9
64	R2.2x43	R2.7x53	28.9125	3.25625	No	Yes	0	9	9
65	R2.2x39	R2.3x49	12.631	3.955	No	No	0	9	9
66	R2.2x39	R2.2x40	12.0951	2.955	No	Yes	0	9	9
67	R1.Alloh56	R2.6x35	11.87	8.955	Yes	No	2	0	8
68	R2.3x40	R2.5x51	12.0721	5.18875	Yes	Yes	5	8	8
69	R2.3x40	R2.5x46	11.6124	4.965	Yes	Yes	5	8	5
70	R2.4x53	R2.5x46	10.0067	6.10375	No	Yes	0	9	5
71	R2.E2	R2.NT	28.6267	75.7225	Yes	Yes	1	4	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R1.NT	R1.NT	3639.86	1	Yes	Yes	6	6	2	2
R1.NT	R2.NT	219.262	1	Yes	Yes	6	6	2	1
R2.NT	R2.NT	3587.32	1	Yes	Yes	6	6	1	1
R2.E2	R2.NT	75.7225	1	Yes	Yes	4	6	2	1
R2.7x31	R2.NT	6.64625	1	No	Yes	5	6	2	1
R2.E1	R2.NT	8.51625	1	Yes	Yes	5	6	2	1
R2.2x61	R2.NT	2.715	0	No	Yes	7	6	2	1
R2.7x32	R2.NT	3.8925	1	Yes	Yes	7	6	2	1
R2.7x35	R2.NT	3.08	1	No	Yes	7	6	2	1
R2.E1	R2.E1	17.48	1	Yes	Yes	5	5	2	2
R2.E1	R2.E2	3.37125	1	Yes	Yes	5	4	2	2
R2.E2	R2.E2	100.156	1	Yes	Yes	4	4	2	2
R2.7x31	R2.E2	8.31625	1	No	Yes	5	4	2	2
R2.Lig	R2.NT	39.5487	0	No	Yes	0	6	0	1
R2.7x31	R2.7x32	2.5875	1	No	Yes	5	7	2	2
R2.7x32	R2.E2	4.9225	1	Yes	Yes	7	4	2	2
R2.1x33	R2.NT	1.34	0	No	Yes	1	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
100.00	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
100.00	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
100.00	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
100.00	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
100.00	Single	7DD5	Ca3	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7EB2	Baclofen	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Single	7FII	hCG	7FII-LH-hCG-6fuf
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
100.00	Single	7XW7	K1-70	7XW7-TSH-K1-70
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-J9R
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
100.00	Consensus	fsh_on_allo	Orthosteric Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
100.00	Consensus	gabab_off	Orthosteric Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Consensus	gabab_on	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_gaba	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gphr_on	Orthosteric Ligand	lh_on tsh_on
100.00	Consensus	gs_gphr	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	gs_protein	Orthosteric Ligand	gs_gphr
100.00	Consensus	lh_on	Orthosteric Ligand	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	lh_on_allo	Orthosteric Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	smo_off_allo	Other Ligand	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Consensus	tsh_on	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2
100.00	Consensus	tsh_on_allo	Orthosteric Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
33.33	Single	8HS2	Fab046	8HS2-GPR20-Fab046
25.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
25.00	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
20.00	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
20.00	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/&β;1/&γ;2
20.00	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
20.00	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
14.29	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
14.29	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
14.29	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
14.29	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
14.29	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
12.50	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
12.50	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
12.50	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50	Consensus	go_protein	Orthosteric Ligand	go_chemokine
12.50	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
11.11	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
11.11	Single	5U09	Taranabant	5U09-CB₁-Taranabant
11.11	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
11.11	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
11.11	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
11.11	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
11.11	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
11.11	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
11.11	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Consensus	class-f_off	Orthosteric Ligand	smo_off
11.11	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
11.11	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
10.00	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
10.00	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
10.00	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
10.00	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
10.00	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
10.00	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
10.00	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
10.00	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
10.00	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
9.09	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
9.09	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
9.09	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
9.09	Single	6D27	CAY10471	6D27-DP₂-CAY10471
9.09	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
9.09	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
9.09	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
9.09	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
9.09	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
9.09	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
9.09	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
9.09	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
9.09	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
9.09	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.33	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
8.33	Single	5C1M	BU72	5C1M-μ-BU72
8.33	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33	Single	7C4S	S1P	7C4S-S1P₃-S1P
8.33	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
8.33	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
8.33	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.33	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
8.33	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
8.33	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.33	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
7.69	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
7.69	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
7.69	Single	5V56	TC114	5V56-SMO-TC114
7.69	Single	5V57	TC114	5V57-SMO-TC114
7.69	Single	6OS1	TRV026	6OS1-AT₁-TRV026
7.69	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
7.69	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.69	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
7.69	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
7.69	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
7.69	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
7.69	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
7.69	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	8E0G	BU72	8E0G-μ-BU72
7.69	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.69	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.69	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.69	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
7.69	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
7.69	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.69	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
7.14	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
7.14	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
7.14	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
7.14	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
7.14	Single	6OS2	TRV026	6OS2-AT₁-TRV026
7.14	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
7.14	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.14	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
7.14	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.14	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
7.14	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
7.14	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
7.14	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
7.14	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
7.14	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
7.14	Consensus	dp_off	Orthosteric Ligand	dp2_off
7.14	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
7.14	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.14	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Consensus	nts_on	Orthosteric Ligand	nts1_on
7.14	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
7.14	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
6.67	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
6.67	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
6.67	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
6.67	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
6.67	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
6.67	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.67	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.67	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.67	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
6.67	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.67	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.67	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
6.25	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
6.25	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
6.25	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
6.25	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.25	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.25	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
6.25	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.25	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
6.25	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
6.25	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
6.25	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
6.25	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
5.88	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
5.88	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.88	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.88	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
5.88	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
5.88	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
5.88	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.88	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
5.88	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.88	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.88	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.88	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
5.88	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.88	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.88	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
5.88	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
5.56	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
5.56	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.56	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
5.56	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.56	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.56	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
5.56	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.56	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
5.56	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.56	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.56	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.56	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
5.26	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
5.26	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
5.26	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.26	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.26	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.26	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
5.26	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.26	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
5.26	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.26	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.26	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
5.26	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
5.00	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
5.00	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
5.00	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
5.00	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.00	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
5.00	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
5.00	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
5.00	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
5.00	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
5.00	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
5.00	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
5.00	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
5.00	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.76	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.76	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
4.76	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.76	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.76	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.76	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.76	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.76	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
4.76	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
4.76	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.76	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
4.76	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
4.55	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
4.55	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
4.55	Single	6FJ3	PTH	6FJ3-PTH1-PTH
4.55	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.55	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.55	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
4.55	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
4.55	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
4.55	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.55	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
4.55	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
4.55	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.55	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
4.55	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.55	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
4.35	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.35	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.35	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.35	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
4.35	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.35	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.35	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.35	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.35	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.35	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.35	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
4.35	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.35	Consensus	go_class-b1	Orthosteric Ligand	go_crf
4.35	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.35	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.17	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
4.17	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.17	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.17	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.17	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
4.17	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
4.17	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
4.17	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
4.17	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.17	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.17	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.17	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.17	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.17	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.00	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
4.00	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.00	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
4.00	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
4.00	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.00	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.00	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.00	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.00	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
4.00	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
3.85	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
3.85	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.85	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.85	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.85	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.85	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
3.85	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
3.70	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.70	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.70	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.70	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.70	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
3.57	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.57	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.57	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.57	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.57	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.57	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.57	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.57	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
3.57	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.45	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
3.45	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
3.33	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.33	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.23	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.23	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
3.23	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.12	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.12	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.12	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.03	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
3.03	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.94	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.86	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R1.NT	R1.NT	3639.86	1	Yes	Yes	6	6	1	1
R1.Lig	R1.NT	80.6062	0	No	Yes	0	6	0	1
R1.NT	R2.NT	219.262	1	Yes	Yes	6	6	1	2
R1.E2	R1.NT	79.145	1	Yes	Yes	4	6	2	1
R1.E3	R1.NT	8.005	1	Yes	Yes	5	6	2	1
R1.E1	R1.NT	25.955	1	Yes	Yes	4	6	2	1
R1.7x35	R1.NT	8.38375	1	Yes	Yes	7	6	2	1
R1.1x36	R1.NT	2.8275	1	No	Yes	5	6	2	1
R1.E1	R1.E1	8.97375	1	Yes	Yes	4	4	2	2
R1.E1	R1.E2	11.17	1	Yes	Yes	4	4	2	2
R1.E2	R1.E2	102.221	1	Yes	Yes	4	4	2	2
R1.E2	R1.E3	7.74	1	Yes	Yes	4	5	2	2
R1.E3	R1.E3	5.545	1	Yes	Yes	5	5	2	2
R2.NT	R2.NT	3587.32	1	Yes	Yes	6	6	2	2
R1.7x32	R1.NT	3.8975	1	No	Yes	0	6	2	1
R1.7x32	R1.E2	2.7625	1	No	Yes	0	4	2	2
R1.7x35	R1.E2	3.755	1	Yes	Yes	7	4	2	2
R1.1x33	R1.NT	0.62125	0	No	Yes	0	6	2	1
R1.1x32	R1.NT	0.6175	0	No	Yes	0	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
100.00	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
100.00	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
100.00	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
100.00	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
100.00	Single	7DD5	Ca3	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7EB2	Baclofen	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Single	7FII	hCG	7FII-LH-hCG-6fuf
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
100.00	Single	7XW7	K1-70	7XW7-TSH-K1-70
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-J9R
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
100.00	Consensus	fsh_on_allo	Orthosteric Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
100.00	Consensus	gabab_off	Orthosteric Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Consensus	gabab_on	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_gaba	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gphr_on	Orthosteric Ligand	lh_on tsh_on
100.00	Consensus	gs_gphr	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	gs_protein	Orthosteric Ligand	gs_gphr
100.00	Consensus	lh_on	Orthosteric Ligand	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	lh_on_allo	Orthosteric Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	smo_off_allo	Other Ligand	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Consensus	tsh_on	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2
100.00	Consensus	tsh_on_allo	Orthosteric Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
33.33	Single	8HS2	Fab046	8HS2-GPR20-Fab046
25.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
25.00	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
20.00	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
20.00	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/&β;1/&γ;2
20.00	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
20.00	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
14.29	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
14.29	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
14.29	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
14.29	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
14.29	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
12.50	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
12.50	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
12.50	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50	Consensus	go_protein	Orthosteric Ligand	go_chemokine
12.50	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
11.11	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
11.11	Single	5U09	Taranabant	5U09-CB₁-Taranabant
11.11	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
11.11	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
11.11	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
11.11	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
11.11	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
11.11	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
11.11	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Consensus	class-f_off	Orthosteric Ligand	smo_off
11.11	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
11.11	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
10.00	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
10.00	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
10.00	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
10.00	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
10.00	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
10.00	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
10.00	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
10.00	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
10.00	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
9.09	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
9.09	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
9.09	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
9.09	Single	6D27	CAY10471	6D27-DP₂-CAY10471
9.09	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
9.09	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
9.09	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
9.09	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
9.09	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
9.09	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
9.09	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
9.09	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
9.09	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
9.09	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.33	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
8.33	Single	5C1M	BU72	5C1M-μ-BU72
8.33	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33	Single	7C4S	S1P	7C4S-S1P₃-S1P
8.33	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
8.33	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
8.33	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.33	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
8.33	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
8.33	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.33	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
7.69	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
7.69	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
7.69	Single	5V56	TC114	5V56-SMO-TC114
7.69	Single	5V57	TC114	5V57-SMO-TC114
7.69	Single	6OS1	TRV026	6OS1-AT₁-TRV026
7.69	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
7.69	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.69	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
7.69	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
7.69	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
7.69	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
7.69	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
7.69	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	8E0G	BU72	8E0G-μ-BU72
7.69	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.69	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.69	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.69	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
7.69	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
7.69	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.69	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
7.14	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
7.14	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
7.14	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
7.14	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
7.14	Single	6OS2	TRV026	6OS2-AT₁-TRV026
7.14	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
7.14	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.14	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
7.14	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.14	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
7.14	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
7.14	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
7.14	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
7.14	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
7.14	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
7.14	Consensus	dp_off	Orthosteric Ligand	dp2_off
7.14	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
7.14	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.14	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Consensus	nts_on	Orthosteric Ligand	nts1_on
7.14	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
7.14	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
6.67	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
6.67	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
6.67	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
6.67	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
6.67	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
6.67	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.67	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.67	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.67	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
6.67	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.67	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.67	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
6.25	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
6.25	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
6.25	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
6.25	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.25	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.25	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
6.25	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.25	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
6.25	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
6.25	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
6.25	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
6.25	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
5.88	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
5.88	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.88	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.88	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
5.88	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
5.88	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
5.88	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.88	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
5.88	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.88	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.88	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.88	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
5.88	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.88	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.88	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
5.88	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
5.56	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
5.56	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.56	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
5.56	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.56	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.56	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
5.56	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.56	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
5.56	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.56	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.56	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.56	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
5.26	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
5.26	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
5.26	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.26	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.26	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.26	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
5.26	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.26	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
5.26	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.26	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.26	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
5.26	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
5.00	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
5.00	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
5.00	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
5.00	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.00	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
5.00	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
5.00	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
5.00	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
5.00	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
5.00	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
5.00	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
5.00	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
5.00	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.76	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.76	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
4.76	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.76	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.76	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.76	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.76	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.76	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
4.76	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
4.76	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.76	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
4.76	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
4.55	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
4.55	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
4.55	Single	6FJ3	PTH	6FJ3-PTH1-PTH
4.55	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.55	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.55	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
4.55	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
4.55	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
4.55	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.55	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
4.55	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
4.55	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.55	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
4.55	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.55	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
4.35	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.35	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.35	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.35	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
4.35	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.35	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.35	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.35	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.35	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.35	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.35	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
4.35	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.35	Consensus	go_class-b1	Orthosteric Ligand	go_crf
4.35	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.35	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.17	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
4.17	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.17	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.17	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.17	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
4.17	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
4.17	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
4.17	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
4.17	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.17	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.17	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.17	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.17	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.17	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.00	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
4.00	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.00	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
4.00	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
4.00	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.00	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.00	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.00	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.00	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
4.00	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
3.85	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
3.85	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.85	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.85	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.85	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.85	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
3.85	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
3.70	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.70	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.70	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.70	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.70	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
3.57	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.57	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.57	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.57	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.57	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.57	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.57	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.57	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
3.57	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.45	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
3.45	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
3.33	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.33	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.23	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.23	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
3.23	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.12	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.12	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.12	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.03	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
3.03	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.94	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.86	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R1.5x59	R1.5x62	5.45625	2	No	No	8	9	1	1
R1.5x59	R1.Alloh56	6.3	2	No	Yes	8	0	1	0
R1.5x62	R1.Alloh56	6.2	2	No	Yes	9	0	1	0
R1.6x42	R1.6x46	5.17	2	Yes	No	9	6	1	2
R1.6x42	R2.6x39	3.59	2	Yes	Yes	9	6	1	1
R1.6x42	R2.6x43	7.3475	2	Yes	No	9	9	1	2
R1.6x42	R1.Alloh56	3.435	2	Yes	Yes	9	0	1	0
R2.I3	R2.I3	12.0662	2	Yes	Yes	7	7	2	2
R1.Alloh56	R2.6x35	8.955	2	Yes	No	0	8	0	1
R2.6x36	R2.7x55	7.24	0	No	No	6	9	1	2
R1.Alloh56	R2.6x36	4.01	2	Yes	No	0	6	0	1
R2.6x39	R2.6x43	2.805	2	Yes	No	6	9	1	2
R1.Alloh56	R2.6x39	3.455	2	Yes	Yes	0	6	0	1
R1.6x39	R2.6x39	5.4925	0	No	Yes	7	6	2	1
R2.6x32	R2.6x35	2.6225	0	No	No	0	8	2	1
R2.6x35	R2.I3	4.9825	2	No	Yes	8	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	7EB2	rac-BHFF	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gabab_on	Other Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_class-c	Other Ligand	gi_mglu gi_gaba
85.71	Consensus	gi_gaba	Other Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
66.67	Single	7C7Q	PubChem 7023848	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
55.56	Single	7CA3	rac-BHFF	7CA3-GABA_B1, GABA_B2-rac-BHFF
42.86	Single	6UO8	GS39783	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
40.00	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
29.41	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
27.78	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
27.27	Single	5VEX	NNC0640	5VEX-GLP-1-NNC0640
27.27	Single	6KK7	PubChem 68178630	6KK7-GLP-1-PubChem 68178630
26.67	Single	6LN2	PubChem 68178630	6LN2-GLP-1-PubChem 68178630
26.32	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
25.00	Single	6KJV	PubChem 68178630	6KJV-GLP-1-PubChem 68178630
25.00	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
23.08	Single	5VEW	PF-06372222	5VEW-GLP-1-PF-06372222
21.43	Single	5XEZ	NNC0640	5XEZ-Glucagon-NNC0640
20.00	Single	5XF1	NNC0640	5XF1-Glucagon-NNC0640
17.65	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
15.38	Single	6KK1	PubChem 68178630	6KK1-GLP-1-PubChem 68178630
15.38	Single	8HNN	SCH546738	8HNN-CXCR3-SCH546738
14.29	Single	7EJX	(1R;2R)-2-PCCA	7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/&β;1/&γ;2
11.11	Single	7DUQ	PubChem 156022738	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
7.69	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
6.67	Single	5X7D	PubChem 129318963	5X7D-β₂-(S)-Carazolol-PubChem 129318963
6.25	Single	7RBT	PubChem 163183774	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	8JPF	PubChem 118610427	8JPF-NTS₁-Neurotensin-PubChem 118610427
5.88	Single	6LFL	PubChem 153466996	6LFL-CXCR2-PubChem 153466996
5.88	Single	8GW8	KHF	8GW8-PTH1-KHF-Gs/&β;1/&γ;2
5.88	Consensus	ffa3_on_allo	Other Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
5.56	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
5.26	Single	5LWE	Vercirnon	5LWE-CCR9-Vercirnon
5.26	Consensus	ccr9_off_allo	Other Ligand	5LWE-CCR9-Vercirnon

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R1.3x36	R1.3x40	5.8825	4	No	Yes	9	8	1	2
R1.3x36	R1.5x47	4.77625	4	No	Yes	9	9	1	1
R1.4x53	R1.5x47	5.335	4	Yes	Yes	9	9	2	1
R1.5x36	R1.5x40	2.825	0	No	No	5	5	2	1
R1.5x40	R1.5x44	7.035	4	No	Yes	5	6	1	1
R1.5x46	R1.5x47	5.065	4	Yes	Yes	7	9	2	1
R1.6x51	R1.6x55	4.80375	0	Yes	No	8	7	2	1
R1.6x55	R1.7x34	6.6975	0	No	No	7	5	1	2
R1.3x36	R1.Allo1	3.73625	4	No	Yes	9	0	1	0
R1.3x40	R1.5x47	3.04375	4	Yes	Yes	8	9	2	1
R1.4x53	R1.5x46	6.19875	4	Yes	Yes	9	7	2	2
R1.5x40	R1.Allo1	3.0825	4	No	Yes	5	0	1	0
R1.5x44	R1.Allo1	2.59375	4	Yes	Yes	6	0	1	0
R1.5x47	R1.Allo1	2.57625	4	Yes	Yes	9	0	1	0
R1.6x55	R1.Allo1	2.64	0	No	Yes	7	0	1	0
R1.5x44	R1.5x48	1.95375	4	Yes	No	6	7	1	2
R1.5x44	R1.6x52	1.85375	4	Yes	No	6	7	1	2
R1.5x44	R1.5x45	1.1525	4	Yes	No	6	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
55.56	Consensus	mglu_on	Other Ligand	mglu2_on mglu4_on
45.45	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
45.45	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
40.00	Single	7EJ0	L-Norepinephrine	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2
40.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
40.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
40.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
38.46	Single	8JD0	J9R	8JD0-mGlu2; mGlu3-Glutamate-J9R
38.46	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
36.36	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
36.36	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
33.33	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
33.33	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
33.33	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
33.33	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
33.33	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
31.25	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
30.77	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
30.77	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
30.77	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
30.00	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
30.00	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
30.00	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
30.00	Single	6QNO	All-trans-retinal	6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
30.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
30.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
28.57	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
28.57	Single	7EPE	NAM563	7EPE-mGlu-NAM563
28.57	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2
28.57	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
28.57	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
28.57	Consensus	mglu2_on	Other Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
27.27	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/&β;1/&γ;2
27.27	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
27.27	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
27.27	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
27.27	Single	8GGF	Epinephrine	8GGF-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
27.27	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2
27.27	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
27.27	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
27.27	Consensus	gs_5ht	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
26.67	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg3_on
26.67	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on
25.00	Single	4DKL	Beta-funaltrexamine	4DKL-μ-Beta-funaltrexamine
25.00	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
25.00	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
25.00	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
25.00	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
25.00	Single	6TPK	Retosiban	6TPK-OT-Retosiban
25.00	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/&β;1/&γ;2
25.00	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
25.00	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
25.00	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
25.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
25.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00	Consensus	5ht5a_off	Orthosteric Ligand	7UM4-5-HT_5A-AS2674723
25.00	Consensus	dop_off_allo	Orthosteric Ligand	4N6H-δ-Naltrindole-Na
25.00	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
25.00	Consensus	vasopressin-ot_off	Orthosteric Ligand	ot_off
23.53	Single	3NY9	PubChem 913103	3NY9-β₂-PubChem 913103
23.53	Consensus	gs_adgr	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
23.53	Consensus	gs_class-b2	Orthosteric Ligand	gs_adgr
23.08	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
23.08	Single	4X1H	Nonyl Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
23.08	Single	5JQH	(S)-Carazolol	5JQH-β₂-(S)-Carazolol
23.08	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
23.08	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
23.08	Single	7CFM	P395	7CFM-GPBA-P395-Gs/&β;1/&γ;2
23.08	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
23.08	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
23.08	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
23.08	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
23.08	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
23.08	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
23.08	Single	8X17	Namodenoson	8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
23.08	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
23.08	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
23.08	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on
23.08	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
23.08	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on
23.08	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
22.22	Single	3RFM	Caffeine	3RFM-A_2A-Caffeine
22.22	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
22.22	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
22.22	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
22.22	Single	8IWM	2-Phenylethylamine	8IWM-TAAR9-2-Phenylethylamine
21.43	Single	4WW3	All-trans-retinal	4WW3-Rhodopsin-All-trans-retinal
21.43	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
21.43	Single	5X7D	(S)-Carazolol	5X7D-β₂-(S)-Carazolol-PubChem 129318963
21.43	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
21.43	Single	6PS6	Timolol	6PS6-β₂-Timolol
21.43	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
21.43	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
21.43	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
21.43	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2
21.43	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
21.43	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/&β;1/&γ;2
21.43	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
21.43	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
21.43	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
21.43	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43	Single	7Y27	Somatostatin-14	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
21.43	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43	Consensus	a1_on_allo	Orthosteric Ligand	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
21.43	Consensus	a2a_on	Orthosteric Ligand	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
21.43	Consensus	gs_sst	Orthosteric Ligand	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
21.05	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
21.05	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
21.05	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
20.00	Single	3UON	Quinuclidinyl benzilate hydrobromide	3UON-M₂-Quinuclidinyl benzilate hydrobromide
20.00	Single	3UZA	GTPL9236	3UZA-A_2A-GTPL9236
20.00	Single	4OO9	Mavoglurant	4OO9-mGlu₅-Mavoglurant
20.00	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
20.00	Single	6E59	L-760735	6E59-NK₁-L-760735
20.00	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
20.00	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
20.00	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/&β;1/&γ;2
20.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
20.00	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
20.00	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
20.00	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/&β;1/&γ;2
20.00	Single	7EW7	PubChem 4077460	7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
20.00	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/&β;1/&γ;2
20.00	Single	7P2L	4YI	7P2L-mGlu₅-4YI
20.00	Single	7S8O	(R)-Zinc-3573	7S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
20.00	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
20.00	Single	8DPI	Lorcaserin	8DPI-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2
20.00	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
20.00	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
20.00	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
20.00	Single	8IU2	Retinal	8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
20.00	Single	8IW7	2-Phenylethylamine	8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00	Single	8J21	Butyric acid	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
20.00	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
20.00	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/&β;1/&γ;2
20.00	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
20.00	Single	8X16	Piclidenoson	8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
20.00	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
20.00	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
20.00	Consensus	5ht1b_on	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
20.00	Consensus	5ht5_off	Orthosteric Ligand	5ht5a_off
20.00	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht5_off 5ht1_off
20.00	Consensus	a2_on	Orthosteric Ligand	a2a_on a2b_on
20.00	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
20.00	Consensus	class-c_off	Other Ligand	gabab_off mglu_off
20.00	Consensus	ffa3_on	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
20.00	Consensus	ffa4_on	Orthosteric Ligand	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
20.00	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A_2A-NECA-Gs/&β;1/&γ;1 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
20.00	Consensus	gs_ffa	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2 8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
20.00	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
20.00	Consensus	nk1_off	Orthosteric Ligand	6J20-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
20.00	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
20.00	Consensus	npy_off	Orthosteric Ligand	npy2_off npy1_off
20.00	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
20.00	Consensus	sst4_on	Orthosteric Ligand	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
19.05	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
19.05	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
18.75	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
18.75	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
18.75	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
18.75	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
18.75	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
18.75	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2
18.75	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
18.75	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
18.75	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
18.75	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/&β;1/&γ;2
18.75	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
18.75	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
18.75	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
18.75	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
18.75	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/&β;1/&γ;2
18.75	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
18.75	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75	Single	8JWY	PubChem 168451710	8JWY-A_2A-PubChem 168451710
18.75	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
18.75	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
18.75	Consensus	gi_class-f	Other Ligand	gi_frizzled
18.75	Consensus	gi_frizzled	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
18.75	Consensus	gpr119_on	Orthosteric Ligand	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
18.75	Consensus	opioid_off	Orthosteric Ligand	kop_off mop_off nop_off dop_off
18.75	Consensus	peptide_off	Orthosteric Ligand	opioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
18.75	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
18.18	Single	3AYM	All-trans-retinal	3AYM-Rhodopsin-All-trans-retinal
18.18	Single	5OLV	LUAA41063	5OLV-A_2A-LUAA41063-Na
18.18	Single	6HLL	CP99994	6HLL-NK₁-CP99994
18.18	Single	6TQ4	PubChem 16046844	6TQ4-OX₁-PubChem 16046844-Na
18.18	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
18.18	Single	7E2Y	Serotonin	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
18.18	Single	7EJK	Oxymetazoline	7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2
18.18	Single	7S8N	(R)-Zinc-3573	7S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18	Single	7SRQ	LSD	7SRQ-5-HT_2B-LSD
18.18	Single	7V68	Iperoxo	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
18.18	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
18.18	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/&β;1/&γ;2
18.18	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2
18.18	Single	7XTB	Serotonin	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2
18.18	Single	7YS6	Serotonin	7YS6-5-HT₆-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
18.18	Single	8A2P	LUAA47070	8A2P-A_2A-LUAA47070-Na
18.18	Single	8DPF	Lorcaserin	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/&β;1/&γ;2
18.18	Single	8GH1	Epinephrine	8GH1-β₂-Epinephrine
18.18	Consensus	5ht4_on	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
17.65	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
17.65	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
17.65	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
17.65	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
17.65	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
17.65	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
17.65	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2
17.65	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
17.65	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.65	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
17.65	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2
17.65	Single	8E9Y	PubChem 446603	8E9Y-M₃-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
17.65	Consensus	beta1_off_allo	Orthosteric Ligand	4BVN-β₁-Cyanopindolol-Na
17.65	Consensus	bileacid_on	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
17.65	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
17.65	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
17.65	Consensus	steroid_on	Orthosteric Ligand	bileacid_on
17.39	Consensus	class-d_on	Orthosteric Ligand	ste2_on
17.24	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
16.67	Single	2X72	All-trans-retinal	2X72-Rhodopsin-All-trans-retinal-Gt(CT)
16.67	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
16.67	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
16.67	Single	3PWH	ZM241385	3PWH-A_2A-ZM241385
16.67	Single	3VGA	ZM241385	3VGA-A_2A-ZM241385-Antibody
16.67	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
16.67	Single	5K2D	ZM241385	5K2D-A_2A-ZM241385
16.67	Single	5OLH	Vipadenant	5OLH-A_2A-Vipadenant-Na
16.67	Single	6AKX	A4R	6AKX-CCR5-A4R
16.67	Single	6B73	PubChem 131955138	6B73-κ-PubChem 131955138
16.67	Single	6JZH	ZM241385	6JZH-A_2A-ZM241385-Na
16.67	Single	6PS7	ZM241385	6PS7-A_2A-ZM241385-Na
16.67	Single	6PT3	DPI-287	6PT3-δ-DPI-287
16.67	Single	6TOD	EMPA	6TOD-OX₁-EMPA-Na
16.67	Single	6TQ6	PubChem 145714283	6TQ6-OX₁-PubChem 145714283
16.67	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
16.67	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
16.67	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2
16.67	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
16.67	Single	7F24	Dopamine	7F24-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
16.67	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
16.67	Single	7LJD	Dopamine	7LJD-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;1
16.67	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
16.67	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
16.67	Single	7SRR	LSD	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67	Single	7SRS	LSD	7SRS-5-HT_2B-LSD-Arrestin2
16.67	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
16.67	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
16.67	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
16.67	Single	7X2F	Dopamine	7X2F-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
16.67	Single	7X5H	5-CT	7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2
16.67	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
16.67	Single	7XY6	PubChem 11717831	7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
16.67	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
16.67	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
16.67	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/&β;1/&γ;2
16.67	Single	8GED	Epinephrine	8GED-β₂-Epinephrine-Gs/&β;1/&γ;2
16.67	Single	8GG9	Epinephrine	8GG9-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
16.67	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67	Single	8UNL	Epinephrine	8UNL-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67	Single	8UNT	Epinephrine	8UNT-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67	Single	8UNU	Epinephrine	8UNU-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67	Single	8UNW	Epinephrine	8UNW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67	Single	8UO0	Epinephrine	8UO0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67	Consensus	5ht2_on	Orthosteric Ligand	5ht2a_on 5ht2c_on
16.67	Consensus	5ht2c_on	Orthosteric Ligand	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67	Consensus	5ht_on	Orthosteric Ligand	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
16.67	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
16.67	Consensus	a2a_off_allo	Orthosteric Ligand	6ZDR-A_2A-HMS1413f12-Na 6GT3-A_2A-Imaradenant-Na 8CU7-A_2A-LJ-4517-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PubChem 92460631; psb36-Na 5MZJ-A_2A-Theophylline-Na 5OLO-A_2A-Tozadenant-Na 5OLH-A_2A-Vipadenant-Na 5NM4-A_2A-ZM241385-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5MZP-A_2A-Caffeine-Na 8CIC-A_2A-Etrumadenant-Na
16.67	Consensus	class-d_off	Orthosteric Ligand	ste2_off
16.67	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
16.67	Consensus	ffa3_on_allo	Orthosteric Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
16.67	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
16.67	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
16.67	Consensus	gi_nucleotide	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
16.67	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
16.67	Consensus	orexin_off	Orthosteric Ligand	ox2_off ox1_off
16.67	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
15.79	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
15.79	Single	7QA8	Peptide	7QA8-STE2-Peptide
15.79	Single	7QA8	Peptide	7QA8-STE2-Peptide
15.79	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
15.79	Consensus	class-d_off	Orthosteric Ligand	ste2_off
15.79	Consensus	mop_off	Orthosteric Ligand	7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
15.38	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
15.38	Single	3REY	PubChem 5697	3REY-A_2A-PubChem 5697
15.38	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
15.38	Single	3UZC	PubChem 135566609	3UZC-A_2A-PubChem 135566609
15.38	Single	4LDO	L-Epinephrine	4LDO-β₂-L-Epinephrine
15.38	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
15.38	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
15.38	Single	5IU4	ZM241385	5IU4-A_2A-ZM241385-Na
15.38	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
15.38	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
15.38	Single	5JTB	ZM241385	5JTB-A_2A-ZM241385
15.38	Single	5K2C	ZM241385	5K2C-A_2A-ZM241385-Na
15.38	Single	5NLX	ZM241385	5NLX-A_2A-ZM241385-Na
15.38	Single	5NM4	ZM241385	5NM4-A_2A-ZM241385-Na
15.38	Single	5TE3	Octyl Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
15.38	Single	5UVI	ZM241385	5UVI-A_2A-ZM241385
15.38	Single	6AQF	ZM241385	6AQF-A_2A-ZM241385
15.38	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
15.38	Single	6MH8	ZM241385	6MH8-A_2A-ZM241385
15.38	Single	6PS4	ICI 118-551	6PS4-β₂-ICI 118-551
15.38	Single	6PS5	(S)-Propranolol	6PS5-β₂-(S)-Propranolol
15.38	Single	6TPG	EMPA	6TPG-OX₂-EMPA
15.38	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
15.38	Single	6VI4	JDTic	6VI4-κ-JDTic
15.38	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
15.38	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
15.38	Single	6ZDV	PubChem 984073	6ZDV-A_2A-PubChem 984073-Na
15.38	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
15.38	Single	7BB6	Acyclovir triphosphate	7BB6-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
15.38	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
15.38	Single	7CMU	Pramipexole	7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
15.38	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/&β;1/&γ;2
15.38	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
15.38	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2
15.38	Single	7EJA	Dexmedetomidine	7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
15.38	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2
15.38	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
15.38	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/&β;1/&γ;2
15.38	Single	7RAN	PubChem 164575847	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38	Single	7SR8	TAK-925	7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.38	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
15.38	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
15.38	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/&β;1/&γ;2
15.38	Single	8DPG	Psilocin	8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38	Single	8GEG	Epinephrine	8GEG-β₂-Epinephrine-Gs/&β;1/&γ;2
15.38	Single	8GG3	Epinephrine	8GG3-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38	Single	8GG5	Epinephrine	8GG5-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38	Single	8GGK	Epinephrine	8GGK-β₂-Epinephrine
15.38	Single	8GGL	Epinephrine	8GGL-β₂-Epinephrine
15.38	Single	8GGM	Epinephrine	8GGM-β₂-Epinephrine
15.38	Single	8GGP	Epinephrine	8GGP-β₂-Epinephrine
15.38	Single	8GGQ	Epinephrine	8GGQ-β₂-Epinephrine
15.38	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2
15.38	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/&β;1/&γ;2
15.38	Single	8T3V	DHA	8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38	Single	8THL	Epinephrine	8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38	Single	8UNR	Epinephrine	8UNR-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38	Single	8UNS	Epinephrine	8UNS-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38	Single	8UNZ	Epinephrine	8UNZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38	Single	8UO2	Epinephrine	8UO2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
15.38	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
15.38	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6WH4-5-HT_2A-Methiothepin 7VOE-5-HT_2A-Aripiprazole 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 6A93-5-HT_2A-Risperidone
15.38	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
15.38	Consensus	5ht5a_on	Orthosteric Ligand	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
15.38	Consensus	alpha2b_on	Orthosteric Ligand	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
15.38	Consensus	d1_on_allo	Orthosteric Ligand	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
15.38	Consensus	d3_on	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
15.38	Consensus	ffa2_on	Orthosteric Ligand	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
15.38	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
15.38	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
15.38	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
15.38	Consensus	ox1_off	Orthosteric Ligand	6TOT-OX₁-Lemborexant 6TP4-OX₁-ACT-462206 6TP6-OX₁-Filorexant 6V9S-OX₁-GTPL11403 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ7-OX₁-SB-334867 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant
15.38	Consensus	ox2_off	Orthosteric Ligand	6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant
15.00	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
15.00	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
15.00	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
15.00	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
15.00	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
15.00	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
15.00	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
15.00	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
14.29	Single	3EML	ZM241385	3EML-A_2A-ZM241385
14.29	Single	3NY8	ICI 118-551	3NY8-β₂-ICI 118-551
14.29	Single	3NYA	(S)-Alprenolol	3NYA-β₂-(S)-Alprenolol
14.29	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
14.29	Single	4DAJ	Tiotropium	4DAJ-M₃-Tiotropium
14.29	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
14.29	Single	4EIY	ZM241385	4EIY-A_2A-ZM241385-Na
14.29	Single	4GBR	(S)-Carazolol	4GBR-β₂-(S)-Carazolol
14.29	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
14.29	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
14.29	Single	4U16	N-Methyl Scopolamine	4U16-M₃-N-Methyl Scopolamine
14.29	Single	5DHG	PubChem 25001412	5DHG-NOP-PubChem 25001412
14.29	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
14.29	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
14.29	Single	5K2A	ZM241385	5K2A-A_2A-ZM241385-Na
14.29	Single	5OLG	ZM241385	5OLG-A_2A-ZM241385-Na
14.29	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
14.29	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
14.29	Single	5UEN	DU172	5UEN-A₁-DU172
14.29	Single	5UIG	J3.651.884G	5UIG-A_2A-J3.651.884G
14.29	Single	5VRA	ZM241385	5VRA-A_2A-ZM241385-Na
14.29	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
14.29	Single	6LPJ	ZM241385	6LPJ-A_2A-ZM241385-Na
14.29	Single	6LPK	ZM241385	6LPK-A_2A-ZM241385-Na
14.29	Single	6PS0	(S)-Carazolol	6PS0-β₂-(S)-Carazolol
14.29	Single	6PS1	Timolol	6PS1-β₂-Timolol
14.29	Single	6PS2	(S)-Alprenolol	6PS2-β₂-(S)-Alprenolol
14.29	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
14.29	Single	6S0L	ZM241385	6S0L-A_2A-ZM241385
14.29	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
14.29	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29	Single	7BTS	L-Epinephrine	7BTS-β₁-L-Epinephrine
14.29	Single	7BU6	L-Norepinephrine	7BU6-β₁-L-Norepinephrine
14.29	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/&β;1/&γ;2
14.29	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
14.29	Single	7F4D	Alpha-MSH	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
14.29	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
14.29	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
14.29	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
14.29	Single	7LJC	PubChem 86764103	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
14.29	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
14.29	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1
14.29	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
14.29	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
14.29	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
14.29	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/&β;1/&γ;2
14.29	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/&β;1/&γ;2
14.29	Single	7T2G	Mitragynine pseudoindoxyl	7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
14.29	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
14.29	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
14.29	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
14.29	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
14.29	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
14.29	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
14.29	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
14.29	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
14.29	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
14.29	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
14.29	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
14.29	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
14.29	Single	8GE3	Epinephrine	8GE3-β₂-Epinephrine-Gs/&β;1/&γ;2
14.29	Single	8GEE	Epinephrine	8GEE-β₂-Epinephrine-Gs/&β;1/&γ;2
14.29	Single	8GEH	Epinephrine	8GEH-β₂-Epinephrine-Gs/&β;1/&γ;2
14.29	Single	8GFW	Epinephrine	8GFW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29	Single	8GFX	Epinephrine	8GFX-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29	Single	8GFY	Epinephrine	8GFY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29	Single	8GFZ	Epinephrine	8GFZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29	Single	8GG0	Epinephrine	8GG0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29	Single	8GG1	Epinephrine	8GG1-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29	Single	8GG2	Epinephrine	8GG2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29	Single	8GG6	Epinephrine	8GG6-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29	Single	8GGB	Epinephrine	8GGB-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29	Single	8GGJ	Epinephrine	8GGJ-β₂-Epinephrine
14.29	Single	8GGN	Epinephrine	8GGN-β₂-Epinephrine
14.29	Single	8GGO	Epinephrine	8GGO-β₂-Epinephrine
14.29	Single	8GGU	Epinephrine	8GGU-β₂-Epinephrine
14.29	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
14.29	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2
14.29	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
14.29	Single	8UNM	Epinephrine	8UNM-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29	Single	8UNN	Epinephrine	8UNN-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29	Single	8UNP	Epinephrine	8UNP-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29	Single	8UO4	Epinephrine	8UO4-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
14.29	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
14.29	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
14.29	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
14.29	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
14.29	Consensus	a2_off	Orthosteric Ligand	a2a_off
14.29	Consensus	a2a_off	Orthosteric Ligand	8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 5UIG-A_2A-J3.651.884G 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-PubChem 168451710 5K2D-A_2A-ZM241385
14.29	Consensus	adrenergic_on	Orthosteric Ligand	beta_on alpha_on
14.29	Consensus	alpha2_on	Orthosteric Ligand	alpha2a_on alpha2b_on
14.29	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
14.29	Consensus	dopamine_on	Orthosteric Ligand	d3_on d2_on d5_on d1_on
14.29	Consensus	ffa_on	Orthosteric Ligand	ffa4_on ffa1_on ffa2_on ffa3_on
14.29	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
14.29	Consensus	gi_5ht	Orthosteric Ligand	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
14.29	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
14.29	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
14.29	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
14.29	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
14.29	Consensus	p2y12_off	Orthosteric Ligand	4NTJ-P2Y₁₂-AZD1283 7PP1-P2Y₁₂-Selatogrel
13.64	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
13.64	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
13.64	Consensus	gi_somatostatin	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
13.64	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
13.33	Single	2RH1	(S)-Carazolol	2RH1-β₂-(S)-Carazolol
13.33	Single	2YCW	(S)-Carazolol	2YCW-β₁-(S)-Carazolol
13.33	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
13.33	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
13.33	Single	5C1M	BU72	5C1M-μ-BU72
13.33	Single	5CGC	HTL14242	5CGC-mGlu₅-HTL14242
13.33	Single	5D6L	(S)-Carazolol	5D6L-β₂-(S)-Carazolol
13.33	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
13.33	Single	5N2S	PSB36	5N2S-A₁-PSB36
13.33	Single	5NM2	ZM241385	5NM2-A_2A-ZM241385-Na
13.33	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
13.33	Single	5WQC	EMPA	5WQC-OX₂-EMPA
13.33	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
13.33	Single	5ZK3	Quinuclidinyl benzilate hydrobromide	5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
13.33	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/&β;1/&γ;2
13.33	Single	6E67	BI167107	6E67-β₂-BI167107-Gs (fused)
13.33	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
13.33	Single	6LPL	ZM241385	6LPL-A_2A-ZM241385-Na
13.33	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
13.33	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
13.33	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
13.33	Single	6PS3	(S)-Carvedilol	6PS3-β₂-(S)-Carvedilol
13.33	Single	6S0Q	ZM241385	6S0Q-A_2A-ZM241385
13.33	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
13.33	Single	6WQA	ZM241385	6WQA-A_2A-ZM241385-Na
13.33	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
13.33	Single	7BVQ	(S)-Carazolol	7BVQ-β₁-(S)-Carazolol
13.33	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/&β;1/&γ;2
13.33	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
13.33	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
13.33	Single	7RM5	ZM241385	7RM5-A_2A-ZM241385-Na
13.33	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2
13.33	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
13.33	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
13.33	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
13.33	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
13.33	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
13.33	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
13.33	Single	7XKA	Epinephrine	7XKA-β₂-Epinephrine
13.33	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
13.33	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
13.33	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/&β;1/&γ;2
13.33	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
13.33	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
13.33	Single	8FYN	ZM241385	8FYN-A_2A-ZM241385-Na
13.33	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
13.33	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
13.33	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
13.33	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
13.33	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
13.33	Single	8QOT	Nanobody E	8QOT-μ-Nanobody E
13.33	Single	8UNY	Epinephrine	8UNY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
13.33	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
13.33	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
13.33	Consensus	adrenergic_off	Orthosteric Ligand	beta_off alpha_off
13.33	Consensus	alpha2a_on	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
13.33	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
13.33	Consensus	amine_off	Orthosteric Ligand	adrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
13.33	Consensus	beta2_off	Orthosteric Ligand	6PS2-β₂-(S)-Alprenolol 6PS3-β₂-(S)-Carvedilol 6PS5-β₂-(S)-Propranolol 6PS6-β₂-Timolol 2RH1-β₂-(S)-Carazolol 6PS4-β₂-ICI 118-551 3NY9-β₂-PubChem 913103
13.33	Consensus	beta2_on	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
13.33	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
13.33	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
13.33	Consensus	gi_adrenergic	Orthosteric Ligand	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
13.33	Consensus	go_amine	Orthosteric Ligand	go_adrenergic go_muscarinic go_5ht
13.33	Consensus	go_opioid	Orthosteric Ligand	8DZQ-κ-momSalB-Go/&β;1/&γ;2
13.33	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
13.33	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
13.33	Consensus	m2_off	Orthosteric Ligand	5ZKB-M₂-AF-DX 384 5ZKC-M₂-N-Methyl Scopolamine 5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
13.04	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
13.04	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
13.04	Single	7KH0	Acyclovir triphosphate	7KH0-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
13.04	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
13.04	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
13.04	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
13.04	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.04	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
12.50	Single	2YDV	NECA	2YDV-A_2A-NECA
12.50	Single	3P0G	BI167107	3P0G-β₂-BI167107
12.50	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/&β;1/&γ;2
12.50	Single	4DJH	JDTic	4DJH-κ-JDTic
12.50	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
12.50	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
12.50	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
12.50	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
12.50	Single	5D5A	(S)-Carazolol	5D5A-β₂-(S)-Carazolol
12.50	Single	5D5B	(S)-Carazolol	5D5B-β₂-(S)-Carazolol
12.50	Single	5G53	NECA	5G53-A_2A-NECA-Gs
12.50	Single	5MZP	Caffeine	5MZP-A_2A-Caffeine-Na
12.50	Single	5V56	TC114	5V56-SMO-TC114
12.50	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
12.50	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
12.50	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
12.50	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
12.50	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
12.50	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.50	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
12.50	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
12.50	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
12.50	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
12.50	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
12.50	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
12.50	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2
12.50	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/&β;1/&γ;2
12.50	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
12.50	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
12.50	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
12.50	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
12.50	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
12.50	Single	7W6P	W96	7W6P-α_2a-W96-Go/&β;1/&γ;2
12.50	Single	7W7E	W58	7W7E-α_2a-W58-Go/&β;1/&γ;2
12.50	Single	7WV9	PubMed 104895	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
12.50	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
12.50	Single	7XOX	Cholecystokinin-8	7XOX-CCK_B-Cholecystokinin-8-Gq/&β;1/&γ;2
12.50	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/&β;1/&γ;2
12.50	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
12.50	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/&β;1/&γ;2
12.50	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/&β;1/&γ;2
12.50	Single	8E0G	BU72	8E0G-μ-BU72
12.50	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/&β;1/&γ;2
12.50	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
12.50	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2
12.50	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/&β;1/&γ;2
12.50	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
12.50	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
12.50	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
12.50	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCZ-β₁-Iodocyanopindolol
12.50	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
12.50	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.50	Consensus	dopamine_off	Orthosteric Ligand	d3_off d2_off d4_off
12.50	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
12.50	Consensus	gi_dopamine	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
12.50	Consensus	gi_ffa	Orthosteric Ligand	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
12.50	Consensus	go_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
12.50	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2
12.50	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
12.50	Consensus	h1_off	Orthosteric Ligand	3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole 8X63-H₁-Mepyramine 8X64-H₁-Desloratadine
12.50	Consensus	histamine_off	Orthosteric Ligand	h1_off
12.50	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
12.50	Consensus	m3_off	Orthosteric Ligand	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl Scopolamine 5ZHP-M₃-PubChem 134828589
12.50	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
12.50	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
12.50	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
12.50	Consensus	nts1_on_allo	Orthosteric Ligand	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.50	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
12.00	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
12.00	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
12.00	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
12.00	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
12.00	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
12.00	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
11.76	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
11.76	Single	3D4S	Timolol Maleate	3D4S-β₂-Timolol Maleate
11.76	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
11.76	Single	4LDE	BI167107	4LDE-β₂-BI167107
11.76	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
11.76	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
11.76	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
11.76	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
11.76	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
11.76	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
11.76	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
11.76	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
11.76	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
11.76	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
11.76	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2
11.76	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
11.76	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
11.76	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.76	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/&β;1/&γ;2
11.76	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
11.76	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76	Single	8I95	EP54	8I95-C3a_B-EP54-Go/&β;1/&γ;2
11.76	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2
11.76	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
11.76	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
11.76	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
11.76	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
11.76	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
11.76	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
11.76	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/&β;1/&γ;2
11.76	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
11.76	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
11.76	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
11.76	Single	8WU1	KCA	8WU1-CB₁-KCA-Arrestin1
11.76	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
11.76	Consensus	go_5ht	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
11.76	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
11.76	Consensus	gs_bileacid	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
11.76	Consensus	gs_steroid	Orthosteric Ligand	gs_bileacid
11.76	Consensus	gs_trh	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.76	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
11.76	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
11.76	Consensus	nts1_off	Orthosteric Ligand	6Z4Q-NTS₁-SR142948A 6Z4S-NTS₁-SR48692
11.76	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
11.76	Consensus	nts_off	Orthosteric Ligand	nts1_off
11.76	Consensus	nts_on	Orthosteric Ligand	nts1_on
11.76	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
11.76	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.54	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
11.54	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
11.54	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
11.54	Single	7VGX	Neuropeptide Y	7VGX-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
11.54	Single	8FEG	PRD_002517	8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
11.54	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
11.54	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
11.54	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
11.11	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
11.11	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
11.11	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
11.11	Single	5CGD	HTL14242	5CGD-mGlu₅-HTL14242
11.11	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
11.11	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
11.11	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/&β;1/&γ;2
11.11	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
11.11	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
11.11	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
11.11	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
11.11	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
11.11	Single	7EZC	UKA	7EZC-A_2A-UKA
11.11	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
11.11	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
11.11	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
11.11	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2
11.11	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/&β;1/&γ;2
11.11	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
11.11	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
11.11	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
11.11	Single	8GAG	YVF	8GAG-CB₁-YVF-Gi1/&β;1/&γ;2
11.11	Single	8GEJ	Epinephrine	8GEJ-β₂-Epinephrine-Gs/&β;1/&γ;2
11.11	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2
11.11	Single	8ID8	TUG-891	8ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
11.11	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
11.11	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
11.11	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
11.11	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11	Single	8WRZ	8D0	8WRZ-CB₁-8D0-Arrestin1
11.11	Consensus	cckb_on	Orthosteric Ligand	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
11.11	Consensus	cyslt2_off	Orthosteric Ligand	6RZ6-CysLT₂-ONO-2570366 6RZ9-CysLT₂-ONO-2770372 6RZ8-CysLT₂-ONO-2080365
11.11	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off
11.11	Consensus	endothelin_off	Orthosteric Ligand	etb_off
11.11	Consensus	etb_off	Orthosteric Ligand	5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500 5X93-ET_B-K-8794
11.11	Consensus	ffa4_on_allo	Orthosteric Ligand	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11	Consensus	gabab_off	Other Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
11.11	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
11.11	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
11.11	Consensus	gs_lipid	Orthosteric Ligand	gs_ffa gs_prostanoid
11.11	Consensus	gs_orexin	Orthosteric Ligand	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11	Consensus	orexin_on	Orthosteric Ligand	ox2_on
10.71	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
10.71	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
10.53	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
10.53	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
10.53	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
10.53	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
10.53	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
10.53	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
10.53	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
10.53	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
10.53	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
10.53	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
10.53	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
10.53	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
10.53	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/&β;1/&γ;2
10.53	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53	Single	8SAI	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine	8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
10.53	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
10.53	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2 8I95-C3a_B-EP54-Go/&β;1/&γ;2
10.53	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
10.53	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
10.53	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
10.53	Consensus	go_vasopressin	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
10.53	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
10.53	Consensus	gs_bombesin	Orthosteric Ligand	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
10.53	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
10.53	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.34	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
10.00	Single	2HPY	All-trans-retinal	2HPY-Rhodopsin-All-trans-retinal
10.00	Single	4AMJ	(S)-Carvedilol	4AMJ-β₁-(S)-Carvedilol
10.00	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
10.00	Single	6OY9	All-trans-retinal	6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
10.00	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
10.00	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
10.00	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
10.00	Single	7MTB	All-trans-retinal	7MTB-Rhodopsin-All-trans-retinal-GRK1
10.00	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
10.00	Single	7VDM	Substance P	7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
10.00	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
10.00	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
10.00	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
10.00	Single	7Y14	Beta-alanine	7Y14-MRGPRD-Beta-alanine
10.00	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
10.00	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
10.00	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
10.00	Single	8DPH	Lorcaserin	8DPH-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
10.00	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
10.00	Single	8G59	TUG-891	8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
10.00	Single	8GHV	PubChem 145964903	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
10.00	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/&β;1/&γ;2
10.00	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
10.00	Single	8WC5	Tetramethylammonium ion	8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
10.00	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
10.00	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
10.00	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
10.00	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
10.00	Consensus	hca2_on_allo	Orthosteric Ligand	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
10.00	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
10.00	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
10.00	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
10.00	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
10.00	Consensus	sst2_on	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
10.00	Consensus	sst_on	Orthosteric Ligand	sst2_on sst4_on
9.68	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
9.68	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
9.52	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
9.52	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/&β;1/&γ;2
9.52	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
9.52	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
9.52	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
9.52	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
9.52	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
9.52	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
9.52	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
9.38	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
9.09	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
9.09	Single	3C9M	11-cis-Retinal	3C9M-Rhodopsin-11-cis-Retinal
9.09	Single	3PQR	All-trans-retinal	3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
9.09	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
9.09	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
9.09	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
9.09	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
9.09	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
9.09	Single	7MT8	All-trans-retinal	7MT8-Rhodopsin-All-trans-retinal-GRK1
9.09	Single	7MT9	All-trans-retinal	7MT9-Rhodopsin-All-trans-retinal-GRK1
9.09	Single	7MTA	All-trans-retinal	7MTA-Rhodopsin-All-trans-retinal-GRK1
9.09	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
9.09	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
9.09	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
9.09	Single	7V6A	PubChem 9864275	7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
9.09	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
9.09	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
9.09	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;2
9.09	Single	7Y12	Beta-alanine	7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
9.09	Single	8EIT	Doconexent	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.09	Single	8GGR	Epinephrine	8GGR-β₂-Epinephrine
9.09	Single	8GGZ	Epinephrine	8GGZ-β₂-Epinephrine
9.09	Single	8J6Q	Beta-hydroxybutyrate	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
9.09	Single	8JGB	Conorfamide-Tx2	8JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
9.09	Single	8POK	Histamine	8POK-H₂-Histamine-Gs/&β;1/&γ;2
9.09	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	8WC9	ZH8651	8WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Consensus	gip_on_allo	Other Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
9.09	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
8.70	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
8.70	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
8.70	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
8.70	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
8.70	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
8.70	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
8.70	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
8.70	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
8.70	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2
8.70	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/&β;1/&γ;2
8.70	Consensus	class-d_on	Orthosteric Ligand	ste2_on
8.70	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
8.70	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
8.70	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
8.33	Single	1L9H	11-cis-Retinal	1L9H-Rhodopsin-11-cis-Retinal
8.33	Single	1U19	11-cis-Retinal	1U19-Rhodopsin-11-cis-Retinal
8.33	Single	2G87	All-trans-retinal	2G87-Rhodopsin-All-trans-retinal
8.33	Single	2I35	11-cis-Retinal	2I35-Rhodopsin-11-cis-Retinal
8.33	Single	3PBL	Eticlopride	3PBL-D₃-Eticlopride
8.33	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
8.33	Single	6TP4	ACT-462206	6TP4-OX₁-ACT-462206
8.33	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
8.33	Single	7DFL	Histamine	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
8.33	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
8.33	Single	7UL2	SR48692	7UL2-NTS₁-SR48692-Na
8.33	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
8.33	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
8.33	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
8.33	Single	7YFC	Histamine	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33	Single	8GEI	Epinephrine	8GEI-β₂-Epinephrine-Gs/&β;1/&γ;2
8.33	Single	8GGC	Epinephrine	8GGC-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
8.33	Single	8GGE	Epinephrine	8GGE-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
8.33	Single	8GGS	Epinephrine	8GGS-β₂-Epinephrine
8.33	Single	8GGY	Epinephrine	8GGY-β₂-Epinephrine
8.33	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2
8.33	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
8.33	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2
8.33	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2
8.33	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/&β;1/&γ;2
8.33	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/&β;1/&γ;2
8.33	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/&β;1/&γ;2
8.33	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
8.33	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
8.33	Single	8UNV	Epinephrine	8UNV-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
8.33	Single	8UNX	Epinephrine	8UNX-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
8.33	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
8.33	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
8.33	Single	8WC3	SEP-363856	8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Consensus	bombesin_on	Orthosteric Ligand	bb2_on bb1_on
8.33	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
8.33	Consensus	d3_off	Orthosteric Ligand	3PBL-D₃-Eticlopride
8.33	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
8.33	Consensus	gq_histamine	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
8.33	Consensus	gs_bradykinin	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
8.33	Consensus	gs_melanocortin	Orthosteric Ligand	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2
8.33	Consensus	h1_on	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
8.33	Consensus	nts1_off_allo	Orthosteric Ligand	7UL2-NTS₁-SR48692-Na
8.33	Consensus	ox1_off_allo	Orthosteric Ligand	6TOD-OX₁-EMPA-Na 6TOS-OX₁-GSK1059865-Na 6TQ4-OX₁-PubChem 16046844-Na 6TO7-OX₁-Suvorexant-Na
8.00	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
8.00	Single	6FJ3	PTH	6FJ3-PTH1-PTH
8.00	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
8.00	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/&β;1/&γ;2
8.00	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
8.00	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
8.00	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
8.00	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
8.00	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
8.00	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
8.00	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
8.00	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
8.00	Consensus	bb1_on	Orthosteric Ligand	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
8.00	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
8.00	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
8.00	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
7.69	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
7.69	Single	1GZM	11-cis-Retinal	1GZM-Rhodopsin-11-cis-Retinal
7.69	Single	2PED	9-cis-Retinal	2PED-Rhodopsin-9-cis-Retinal
7.69	Single	3C9L	11-cis-Retinal	3C9L-Rhodopsin-11-cis-Retinal
7.69	Single	3VG9	ZM241385	3VG9-A_2A-ZM241385-Antibody
7.69	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
7.69	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
7.69	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
7.69	Single	5WS3	EMPA	5WS3-OX₂-EMPA
7.69	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
7.69	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
7.69	Single	6KUY	PubChem 145704643	6KUY-α_2a-PubChem 145704643
7.69	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
7.69	Single	6NWE	Octyl Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
7.69	Single	6OBA	(S)-Alprenolol	6OBA-β₂-(S)-Alprenolol-GTPL11074
7.69	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
7.69	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
7.69	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
7.69	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
7.69	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
7.69	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
7.69	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
7.69	Single	7T6S	PubChem 24776341	7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
7.69	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
7.69	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
7.69	Single	7TUZ	7alpha,25-dihydroxycholesterol	7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
7.69	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
7.69	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
7.69	Single	7XRR	Lemborexant	7XRR-OX₂-Lemborexant
7.69	Single	7YM8	Oxymetazoline	7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
7.69	Single	7YMH	Norepinephrine	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
7.69	Single	8A6C	All-trans-retinal	8A6C-Rhodopsin-All-trans-retinal
7.69	Single	8A6D	All-trans-retinal	8A6D-Rhodopsin-All-trans-retinal
7.69	Single	8A6E	All-trans-retinal	8A6E-Rhodopsin-All-trans-retinal
7.69	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
7.69	Single	8GEA	Epinephrine	8GEA-β₂-Epinephrine-Gs/&β;1/&γ;2
7.69	Single	8GEC	Epinephrine	8GEC-β₂-Epinephrine-Gs/&β;1/&γ;2
7.69	Single	8GEF	Epinephrine	8GEF-β₂-Epinephrine-Gs/&β;1/&γ;2
7.69	Single	8GG7	Epinephrine	8GG7-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.69	Single	8GGA	Epinephrine	8GGA-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.69	Single	8GGV	Epinephrine	8GGV-β₂-Epinephrine
7.69	Single	8GGW	Epinephrine	8GGW-β₂-Epinephrine
7.69	Single	8GGX	Epinephrine	8GGX-β₂-Epinephrine
7.69	Single	8GH0	Epinephrine	8GH0-β₂-Epinephrine
7.69	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
7.69	Single	8HNN	SCH546738	8HNN-CXCR3-SCH546738
7.69	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
7.69	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
7.69	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2
7.69	Single	8IW4	Spermidine	8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Single	8IWE	Spermidine	8IWE-TAAR9-Spermidine
7.69	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/&β;1/&γ;2
7.69	Single	8U8F	PML	8U8F-GPR3-PML-Gs/&β;1/&γ;2
7.69	Single	8UNO	Epinephrine	8UNO-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.69	Single	8UO1	Epinephrine	8UO1-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
7.69	Single	8UO3	Epinephrine	8UO3-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
7.69	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Consensus	alpha1_on	Orthosteric Ligand	alpha1a_on
7.69	Consensus	alpha1a_on	Orthosteric Ligand	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Consensus	alpha2_off	Orthosteric Ligand	alpha2a_off alpha2c_off
7.69	Consensus	beta2_off_allo	Orthosteric Ligand	6OBA-β₂-(S)-Alprenolol-GTPL11074
7.69	Consensus	class-f_off	Orthosteric Ligand	smo_off
7.69	Consensus	gi_histamine	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2 8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
7.69	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
7.69	Consensus	gs_histamine	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69	Consensus	h4_on	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
7.69	Consensus	opsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
7.69	Consensus	smo_on_allo	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
7.41	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
7.41	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
7.41	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
7.41	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
7.41	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
7.41	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
7.41	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
7.41	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
7.41	Consensus	crf1_on	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
7.41	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
7.41	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
7.14	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
7.14	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
7.14	Single	4MQT	Iperoxo	4MQT-M₂-Iperoxo-LY2119620
7.14	Single	5K2B	ZM241385	5K2B-A_2A-ZM241385-Na
7.14	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
7.14	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
7.14	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
7.14	Single	6FFI	MMPEP	6FFI-mGlu₅-MMPEP
7.14	Single	6IQL	L745870	6IQL-D₄-L745870
7.14	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
7.14	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
7.14	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
7.14	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
7.14	Single	6WJC	Atropine	6WJC-M₁-Atropine-Muscarinic toxin 7
7.14	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
7.14	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
7.14	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
7.14	Single	6ZIN	SR48692	6ZIN-NTS₁-SR48692
7.14	Single	7DHI	Salbutamol	7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
7.14	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
7.14	Single	7F61	PF-03654746	7F61-H₃-PF-03654746-Cholesterol
7.14	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
7.14	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2
7.14	Single	7UM7	Methylergometrine	7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
7.14	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
7.14	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
7.14	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
7.14	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
7.14	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
7.14	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
7.14	Single	8DWG	ML382	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
7.14	Single	8GDZ	Epinephrine	8GDZ-β₂-Epinephrine-Gs/&β;1/&γ;2
7.14	Single	8GE1	Epinephrine	8GE1-β₂-Epinephrine-Gs/&β;1/&γ;2
7.14	Single	8GE4	Epinephrine	8GE4-β₂-Epinephrine-Gs/&β;1/&γ;2
7.14	Single	8GE6	Epinephrine	8GE6-β₂-Epinephrine-Gs/&β;1/&γ;2
7.14	Single	8GE7	Epinephrine	8GE7-β₂-Epinephrine-Gs/&β;1/&γ;2
7.14	Single	8GE8	Epinephrine	8GE8-β₂-Epinephrine-Gs/&β;1/&γ;2
7.14	Single	8GE9	Epinephrine	8GE9-β₂-Epinephrine-Gs/&β;1/&γ;2
7.14	Single	8GFV	Epinephrine	8GFV-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.14	Single	8GG4	Epinephrine	8GG4-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.14	Single	8GG8	Epinephrine	8GG8-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.14	Single	8GGI	Epinephrine	8GGI-β₂-Epinephrine
7.14	Single	8GGT	Epinephrine	8GGT-β₂-Epinephrine
7.14	Single	8GUR	PubChem 104895	8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2
7.14	Single	8HJ5	PubChem 139030531	8HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
7.14	Single	8HQN	9(S)-HODE	8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
7.14	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
7.14	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/&β;1/&γ;2
7.14	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/&β;1/&γ;2
7.14	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2
7.14	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/&β;1/&γ;2
7.14	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
7.14	Single	8JSP	Ulotaront	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2
7.14	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
7.14	Single	8THK	A61603	8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/&β;1/&γ;2
7.14	Single	8UNQ	Epinephrine	8UNQ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.14	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2
7.14	Consensus	5ht2a_on	Orthosteric Ligand	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
7.14	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
7.14	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
7.14	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
7.14	Consensus	gs_crf	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
7.14	Consensus	gs_tar	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Consensus	h3_on_allo	Orthosteric Ligand	7F61-H₃-PF-03654746-Cholesterol
7.14	Consensus	hca_on	Orthosteric Ligand	hca2_on hca3_on
7.14	Consensus	hcar_on	Orthosteric Ligand	hca_on
7.14	Consensus	m1_off_allo	Orthosteric Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
7.14	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
7.14	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
7.14	Consensus	sensory_off	Orthosteric Ligand	opsin_off
6.90	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
6.90	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
6.90	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
6.67	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
6.67	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
6.67	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
6.67	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
6.67	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
6.67	Single	3ZPR	4-methyl-2-(piperazin-1-yl)	3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
6.67	Single	4MQS	Iperoxo	4MQS-M₂-Iperoxo
6.67	Single	4QKX	PubChem 76210628	4QKX-β₂-PubChem 76210628
6.67	Single	4U14	Tiotropium	4U14-M₃-Tiotropium
6.67	Single	5YC8	N-Methyl Scopolamine	5YC8-M₂-N-Methyl Scopolamine
6.67	Single	5ZK8	N-Methyl Scopolamine	5ZK8-M₂-N-Methyl Scopolamine
6.67	Single	5ZKC	N-Methyl Scopolamine	5ZKC-M₂-N-Methyl Scopolamine
6.67	Single	5ZKP	Foropafant (SR27417)	5ZKP-PAF-Foropafant (SR27417)
6.67	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
6.67	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
6.67	Single	6FFH	Fenobam	6FFH-mGlu₅-Fenobam
6.67	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
6.67	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2
6.67	Single	6PRZ	(S)-Alprenolol	6PRZ-β₂-(S)-Alprenolol
6.67	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
6.67	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
6.67	Single	7BU7	BI167107	7BU7-β₁-BI167107
6.67	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
6.67	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
6.67	Single	7TRP	Iperoxo	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
6.67	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/&β;1/&γ;2
6.67	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
6.67	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
6.67	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
6.67	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
6.67	Single	7XJH	Isoproterenol	7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
6.67	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
6.67	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
6.67	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
6.67	Single	8EJC	TAK-875	8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	8EJK	TAK-875	8EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	8GEB	Epinephrine	8GEB-β₂-Epinephrine-Gs/&β;1/&γ;2
6.67	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/&β;1/&γ;2
6.67	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/&β;1/&γ;2
6.67	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
6.67	Single	8J18	(3R)-3-hydroxydodecanoic acid	8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
6.67	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
6.67	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
6.67	Single	8JLJ	T1AM	8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
6.67	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
6.67	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
6.67	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
6.67	Single	8WC7	ZH8667	8WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Consensus	5ht1a_on	Orthosteric Ligand	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
6.67	Consensus	amine_on	Orthosteric Ligand	adrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
6.67	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
6.67	Consensus	blt_on	Orthosteric Ligand	blt1_on
6.67	Consensus	cb1_on_allo	Orthosteric Ligand	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
6.67	Consensus	cck_off	Orthosteric Ligand	ccka_off
6.67	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
6.67	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Consensus	ffa1_on	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67	Consensus	gi_hca	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
6.67	Consensus	gi_hcar	Orthosteric Ligand	gi_hca
6.67	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
6.67	Consensus	go_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
6.67	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
6.67	Consensus	hca2_on	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
6.67	Consensus	hca3_on	Orthosteric Ligand	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
6.67	Consensus	histamine_on	Orthosteric Ligand	h1_on h4_on
6.67	Consensus	leuko_on	Orthosteric Ligand	blt_on
6.67	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
6.67	Consensus	m2_on_allo	Orthosteric Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
6.67	Consensus	m4_on_allo	Orthosteric Ligand	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.67	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
6.67	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
6.67	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
6.67	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
6.67	Consensus	tar_on	Orthosteric Ligand	ta1_on
6.45	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
6.25	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
6.25	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
6.25	Single	4PHU	Fasiglifam	4PHU-FFA1 (GPR40)-Fasiglifam
6.25	Single	5N2R	PubChem 92460631; psb36	5N2R-A_2A-PubChem 92460631; psb36-Na
6.25	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
6.25	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
6.25	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
6.25	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
6.25	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
6.25	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
6.25	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
6.25	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
6.25	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
6.25	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
6.25	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
6.25	Single	7C4S	S1P	7C4S-S1P₃-S1P
6.25	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
6.25	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
6.25	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
6.25	Single	7TRK	Iperoxo	7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2
6.25	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
6.25	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.25	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
6.25	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
6.25	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2
6.25	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/&β;1/&γ;2
6.25	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
6.25	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
6.25	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
6.25	Single	8J19	PubChem 127045422	8J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
6.25	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
6.25	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
6.25	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide 6DRX-5-HT_2B-Lisuride
6.25	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
6.25	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
6.25	Consensus	cb2_on	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
6.25	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
6.25	Consensus	d4_off	Orthosteric Ligand	5WIU-D₄-Nemonapride
6.25	Consensus	d4_off_allo	Orthosteric Ligand	5WIV-D₄-Nemonapride-Na
6.25	Consensus	ep3_on	Orthosteric Ligand	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
6.25	Consensus	gs_adrenergic	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJI-β₃-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
6.25	Consensus	gs_muscarinic	Orthosteric Ligand	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
6.25	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
5.88	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
5.88	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
5.88	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
5.88	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
5.88	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
5.88	Single	5TZR	-	5TZR-FFA1 (GPR40)-MK8666
5.88	Single	5V57	TC114	5V57-SMO-TC114
5.88	Single	5X93	K-8794	5X93-ET_B-K-8794
5.88	Single	5XR8	AM841	5XR8-CB₁-AM841
5.88	Single	5XRA	AM11542	5XRA-CB₁-AM11542
5.88	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
5.88	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
5.88	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
5.88	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
5.88	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2
5.88	Single	7FEE	PubMed 104895	7FEE-CB₁-PubMed 104895-ZCZ011
5.88	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
5.88	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
5.88	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
5.88	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
5.88	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
5.88	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
5.88	Single	7W41	PD176252	7W41-BB₂-PD176252
5.88	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
5.88	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2
5.88	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
5.88	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
5.88	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
5.88	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
5.88	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2
5.88	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2
5.88	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/&β;1/&γ;2
5.88	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
5.88	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
5.88	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/&β;1/&γ;2
5.88	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/&β;1/&γ;2
5.88	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
5.88	Consensus	alpha1b_off	Orthosteric Ligand	7B6W-α_1b-Cyclazosin
5.88	Consensus	angiotensin_off	Orthosteric Ligand	at1_off at2_off
5.88	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
5.88	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
5.88	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
5.88	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
5.88	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
5.88	Consensus	cyslt1_off_ortoallo	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
5.88	Consensus	gi_muscarinic	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
5.88	Consensus	gs_compl-peptide	Orthosteric Ligand	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
5.88	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
5.88	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
5.88	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
5.88	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
5.88	Consensus	s1p2_on	Orthosteric Ligand	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
5.71	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
5.56	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
5.56	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
5.56	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
5.56	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
5.56	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
5.56	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
5.56	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
5.56	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
5.56	Single	6H7N	(S)-Xamoterol	6H7N-β₁-(S)-Xamoterol
5.56	Single	6KQI	PubMed 104895	6KQI-CB₁-PubMed 104895-ORG27569
5.56	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
5.56	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
5.56	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
5.56	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
5.56	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1
5.56	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2
5.56	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
5.56	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
5.56	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
5.56	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
5.56	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.56	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.56	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2
5.56	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2
5.56	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2
5.56	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2
5.56	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
5.56	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/&β;1/&γ;2
5.56	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
5.56	Consensus	at2_off	Orthosteric Ligand	7JNI-AT₂-Olodanrigan
5.56	Consensus	beta1_on	Orthosteric Ligand	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
5.56	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
5.56	Consensus	cannabinoid_on	Orthosteric Ligand	cb1_on cb2_on
5.56	Consensus	cb1_off_allo	Orthosteric Ligand	6KQI-CB₁-PubMed 104895-ORG27569
5.56	Consensus	cb1_on	Orthosteric Ligand	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
5.56	Consensus	ep_on	Orthosteric Ligand	ep4_on ep2_on ep3_on
5.56	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
5.56	Consensus	gi_prostanoid	Orthosteric Ligand	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2 8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
5.56	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
5.56	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.56	Consensus	leuko_off	Orthosteric Ligand	blt_off cyslt_off
5.56	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
5.56	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
5.56	Consensus	prostanoid_on	Orthosteric Ligand	ep_on fpa_on
5.26	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
5.26	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
5.26	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
5.26	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
5.26	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
5.26	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
5.26	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
5.26	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
5.26	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
5.26	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
5.26	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/&β;1/&γ;2
5.26	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
5.26	Consensus	ep4_on	Orthosteric Ligand	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2
5.26	Consensus	fpa_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	gs_prostanoid	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	ot_on	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
5.00	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
5.00	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
5.00	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
5.00	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
5.00	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.00	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
5.00	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
5.00	Single	8INR	Alpha-MSH	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/&β;1/&γ;2
5.00	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
5.00	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
5.00	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
5.00	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
5.00	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
5.00	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
4.76	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
4.76	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
4.76	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
4.76	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
4.76	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
4.76	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
4.76	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
4.76	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
4.76	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
4.76	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
4.76	Consensus	fpr-alx_on	Orthosteric Ligand	fpr1-alx_on fpr2-alx_on
4.76	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
4.76	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
4.76	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
4.76	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
4.55	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
4.55	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
4.55	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
4.55	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
4.55	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
4.55	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
4.55	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off alpha1b_off
4.55	Consensus	cx3cr_on	Orthosteric Ligand	cx3cr1_on
4.55	Consensus	sst_off	Orthosteric Ligand	sst2_off
4.35	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
4.35	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
4.35	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
4.35	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
4.35	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
4.35	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
4.35	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
4.35	Consensus	cx3cr1_on	Orthosteric Ligand	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
4.35	Consensus	gi_chemerin	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
4.35	Consensus	gi_formylpeptide	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
4.35	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
4.35	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
4.35	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
4.17	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
4.17	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
4.17	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
4.17	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.17	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.17	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
4.17	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
4.17	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.17	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
4.17	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
4.17	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
4.17	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
4.17	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
4.17	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
4.17	Consensus	nmur2_on	Orthosteric Ligand	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Consensus	nmur_on	Orthosteric Ligand	nmur1_on nmur2_on
4.17	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
4.17	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
4.00	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.00	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.00	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.00	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.00	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.00	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
4.00	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.00	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
4.00	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
4.00	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
4.00	Consensus	bk1_on	Orthosteric Ligand	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.00	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Consensus	gs_neuromedin	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.85	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
3.85	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
3.85	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
3.85	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
3.85	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
3.85	Consensus	gi_neuromedin	Orthosteric Ligand	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
3.85	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
3.70	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
3.70	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
3.70	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
3.70	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.70	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
3.70	Consensus	etb_on	Orthosteric Ligand	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
3.70	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
3.70	Consensus	go_class-b1	Orthosteric Ligand	go_crf
3.70	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.70	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.57	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
3.57	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
3.57	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
3.57	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
3.57	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
3.57	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
3.57	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
3.57	Consensus	gs_endothelin	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.57	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
3.45	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
3.45	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
3.45	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.45	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.45	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.45	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
3.33	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
3.33	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
3.33	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
3.33	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
3.23	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.23	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.23	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.23	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.23	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
3.12	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.12	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.12	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.12	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.12	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.03	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
2.86	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
2.78	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.78	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
2.63	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1

Consensus Members
	Id	Members
	gabab_on	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
	mglu_on	mglu2_on mglu4_on

Net Summary
I_min	2.53625
Number of Linked Nodes	478
Number of Links	539
Number of Hubs	65
Number of Links mediated by Hubs	286
Number of Communities	13
Number of Nodes involved in Communities	99
Number of Links involved in Communities	134

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	217901
Length Of Smallest Path	3
Average Path Length	21.1219
Length of Longest Path	46
Minimum Path Strength	0.4475
Average Path Strength	13.7731
Maximum Path Strength	113.889
Minimum Path Correlation	0.7
Average Path Correlation	0.972949
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.38095
Average % Of Corr. Nodes	60.9548
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.9617
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
	Id	1^st Network	2^nd Network
	class-c_off_on	class-c_off	class-c_on

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Download class-c_on.zip

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