Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:R57 9.12405
2R:R:F65 4.4975407
3R:R:S68 3.595408
4R:R:N72 7.15409
5R:R:I75 4.95409
6R:R:F92 4.645608
7R:R:M108 6.21407
8R:R:F120 7.838528
9R:R:F122 5.95426
10R:R:R152 5.8654119
11R:R:L160 4.815407
12R:R:W165 6.975405
13R:R:Q166 8.245147
14R:R:H170 5.4175407
15R:R:M186 4.2775428
16R:R:Y189 7.24627
17R:R:C205 6.37529
18R:R:H207 7.3525425
19R:R:W209 7.0225426
20R:R:W218 6.35571727
21R:R:F227 5.19408
22R:R:Y238 6.485409
23R:R:W346 6.726676158
24R:R:P348 2.935409
25R:R:W355 3.6375405
26R:R:I372 8.485424
27R:R:H376 6.14425
28R:R:Y380 6.57167627
29R:R:N386 5.945409
30R:R:Y390 5.036676119
31R:R:F392 5.275406
32B:B:V40 4.6125183
33B:B:H54 9.538549
34B:B:Y59 7.628518
35B:B:W63 5.30333697
36B:B:D76 5.4125409
37B:B:I80 8.6275448
38B:B:I81 5.034197
39B:B:W82 8.09143749
40B:B:N88 6.655407
41B:B:K89 6.06833649
42B:B:H91 5.27254195
43B:B:W99 6.65286719
44B:B:C103 3.00254208
45B:B:Y105 5.152506
46B:B:Y111 5.332504
47B:B:L117 5.5575419
48B:B:Y124 5.823336216
49B:B:H142 8.118519
50B:B:Y145 5.145618
51B:B:C149 3.096518
52B:B:F151 3.88619
53B:B:I157 3.604517
54B:B:T159 5.514519
55B:B:S161 5.696519
56B:B:D163 8.4725419
57B:B:W169 9.88833618
58B:B:F180 7.888577
59B:B:T181 2.7575402
60B:B:H183 9.2325409
61B:B:D186 4.875419
62B:B:F199 6.67333679
63B:B:V200 7.5825456
64B:B:C204 4.3725417
65B:B:K209 10.9075476
66B:B:W211 9.502578
67B:B:D212 9.76254239
68B:B:H225 7.205659
69B:B:D228 6.592519
70B:B:I232 5.3325458
71B:B:F234 4.78455
72B:B:F235 5.897126
73B:B:P236 5.66754127
74B:B:F241 6.64167656
75B:B:T243 6.62458
76B:B:D246 8.3175419
77B:B:R251 8.976558
78B:B:F253 6.79167656
79B:B:M262 5.54404
80B:B:Y264 6.482505
81B:B:F278 4.003336127
82B:B:G282 3.44754129
83B:B:R283 9.2354189
84B:B:Y289 6.076676137
85B:B:N295 6.03254136
86B:B:W297 4.254138
87B:B:H311 8.2275489
88B:B:L318 4.126586
89B:B:T329 5.785488
90B:B:W332 11.8883619
91B:B:D333 7.2725489
92B:B:W339 7.788509
93G:G:L19 2.465409
94G:G:R27 6.7465178
95G:G:Y40 9.874126
96G:G:D48 7.625409
97G:G:F61 5.02857748
98A:A:R27 2.3275404
99A:A:L42 4.202536
100A:A:T47 5.23568
101A:A:F55 6.872537
102A:A:I189 5.605419
103A:A:F201 5.52333637
104A:A:R202 8.83754247
105A:A:Q209 5.35419
106A:A:S211 4.735418
107A:A:K215 7.0925419
108A:A:W216 6.11857719
109A:A:F220 7.73409
110A:A:M227 3.916537
111A:A:F228 7.1225469
112A:A:E234 6.26467
113A:A:Y235 8.3365108
114A:A:D236 11.84109
115A:A:R247 4.655409
116A:A:F255 6.728569
117A:A:I259 3.60167665
118A:A:Y261 4.27518
119A:A:F264 4.7925419
120A:A:I270 4.5575438
121A:A:F272 5.86833639
122A:A:K276 4.23754275
123A:A:L279 5.1054108
124A:A:I283 4.544106
125A:A:F308 8.215407
126A:A:N317 5.91467
127A:A:Y325 7.3045268
128A:A:T329 7.705439
129A:A:C330 3.9875407
130A:A:I348 4.1625408
131A:A:Y356 8.2754144
132L:L:?12 6.51125820
133L:L:W14 10.134520
134L:L:D16 8.4375420
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:M108 R:R:Y380 20.15715.99YesYes077
2R:R:H376 R:R:Y380 15.72611.98YesYes257
3R:R:M108 R:R:S68 35.4643.07YesYes078
4R:R:N72 R:R:S68 24.56794.47YesYes098
5R:R:A383 R:R:S68 12.27093.42NoYes098
6R:R:L145 R:R:Y390 41.6123.52NoYes099
7R:R:L145 R:R:N386 41.39426.87NoYes099
8R:R:D100 R:R:N386 26.60514.04NoYes099
9R:R:D100 R:R:N72 13.885412.12NoYes099
10R:R:N386 R:R:P387 14.11253.26YesNo099
11R:R:N72 R:R:P387 13.88536.52YesNo099
12R:R:A383 R:R:D100 12.4974.63NoNo099
13R:R:F92 R:R:I148 69.81713.77YesNo089
14R:R:I148 R:R:R152 19.2346.26NoYes1199
15R:R:R152 R:R:Y238 17.72456.17YesYes099
16R:R:A149 R:R:Y238 16.58825.34NoYes099
17R:R:A149 R:R:M234 16.13413.22NoNo098
18R:R:F342 R:R:M234 14.76737.46NoNo098
19R:R:F342 R:R:W346 14.32366.01NoYes098
20R:R:S379 R:R:W346 12.92757.41NoYes078
21R:R:I148 R:R:Y390 50.36373.63NoYes1199
22R:R:E151 R:R:Q166 92.38077.65NoYes097
23R:R:E151 R:R:F92 91.23548.16NoYes098
24R:R:I175 R:R:S95 19.4667.74NoNo079
25R:R:S95 R:R:W179 19.01686.18NoNo099
26R:R:V140 R:R:W179 18.792522.07NoNo089
27R:R:S182 R:R:V140 18.40434.85NoNo088
28R:R:S182 R:R:V136 17.26173.23NoNo086
29R:R:M186 R:R:V136 16.34213.04YesNo086
30R:R:M186 R:R:Y189 12.19363.59YesYes287
31R:R:A155 R:R:Q166 97.15554.55NoYes1487
32A:A:N352 R:R:A155 98.05173.13NoNo088
33A:A:I348 A:A:N352 98.26684.25YesNo088
34A:A:I348 R:R:L160 65.78634.28YesYes087
35A:A:V199 R:R:L160 33.11414.47NoYes047
36A:A:F341 R:R:L160 33.10214.87NoYes087
37A:A:L40 A:A:T224 32.96297.37NoNo057
38A:A:I348 A:A:T224 32.89933.04YesNo087
39R:R:A363 R:R:W355 10.37423.89NoYes035
40L:L:W14 R:R:A363 11.52663.89YesNo003
41A:A:R213 A:A:W216 97.45993NoYes099
42A:A:L254 A:A:R213 97.50196.07NoNo099
43A:A:F228 A:A:L254 97.77154.87YesNo099
44A:A:F228 A:A:T47 97.55383.89YesYes698
45A:A:S50 A:A:T47 99.92546.4NoYes098
46A:A:L229 A:A:S50 99.99983NoNo079
47A:A:F55 A:A:L229 1008.53YesNo377
48A:A:F55 A:A:M59 49.07017.46YesNo079
49A:A:I337 A:A:M59 49.06774.37NoNo079
50A:A:I337 A:A:L196 49.05564.28NoNo075
51A:A:F201 A:A:L196 49.05396.09YesNo075
52A:A:F201 A:A:L40 33.09057.31YesNo075
53A:A:F272 A:A:F55 50.43387.5YesYes397
54A:A:F272 A:A:M227 50.05153.73YesYes397
55A:A:L42 A:A:M227 49.88315.65YesYes367
56A:A:F201 A:A:L42 50.4573.65YesYes376
57A:A:F201 A:A:V199 33.24143.93YesNo074
58A:A:F201 A:A:F341 33.16584.29YesNo078
59B:B:T221 G:G:E22 16.60828.47NoNo079
60B:B:K209 B:B:T221 16.776812.01YesNo067
61B:B:K209 B:B:W211 18.43778.12YesYes768
62B:B:F199 B:B:W211 20.604313.03YesYes798
63B:B:F199 B:B:L192 23.31143.65YesNo095
64B:B:L192 B:B:R150 23.81023.64NoNo056
65B:B:H62 B:B:R150 26.356911.28NoNo066
66B:B:H62 B:B:Y105 26.52273.27NoYes066
67B:B:L126 B:B:Y105 27.12843.52NoYes056
68B:B:L126 B:B:V112 27.77515.96NoNo058
69B:B:V112 B:B:Y124 27.943.79NoYes086
70B:B:S122 B:B:Y124 31.10745.09NoYes2186
71B:B:E138 B:B:S122 31.440410.06NoNo068
72B:B:E138 B:B:I120 31.60448.2NoNo066
73B:B:D118 B:B:I120 32.09584.2NoNo096
74B:B:D118 B:B:S97 32.259511.78NoNo098
75B:B:S97 B:B:W99 32.42323.71NoYes089
76B:B:L117 B:B:W99 37.14063.42YesYes199
77A:A:W216 B:B:L117 36.2519.11YesYes199
78A:A:F220 B:B:W99 36.09210.02YesYes099
79A:A:F220 A:A:W216 36.25636.01YesYes099
80B:B:I18 G:G:E22 14.91985.47NoNo079
81B:B:I18 G:G:R27 14.75065.01NoYes078
82B:B:W297 B:B:Y264 53.38434.82YesYes085
83B:B:W297 B:B:Y289 54.55975.79YesYes1387
84B:B:C271 B:B:Y289 58.45194.03NoYes057
85B:B:C271 B:B:D290 59.9186.22NoNo056
86B:B:D290 B:B:R314 60.157919.06NoNo068
87B:B:R314 B:B:W332 60.397720.99NoYes089
88B:B:W332 B:B:Y59 41.37897.72YesYes198
89B:B:Q75 B:B:Y59 41.72219.02NoYes198
90B:B:Q75 B:B:W99 42.04896.57NoYes199
91A:A:H218 B:B:W332 19.71785.29NoYes189
92A:A:H218 A:A:W263 19.79687.41NoNo085
93A:A:W263 A:A:Y261 20.1034.82NoYes058
94A:A:I217 A:A:Y261 20.33314.84NoYes188
95A:A:I217 A:A:W216 20.66653.52NoYes189
96B:B:L300 B:B:R283 12.567710.93NoYes069
97B:B:L300 G:G:C41 12.81767.94NoNo067
98B:B:F235 G:G:C41 13.06764.19YesNo067
99B:B:F235 B:B:F278 16.61396.43YesYes1267
100B:B:F278 B:B:L285 46.85066.09YesNo076
101B:B:L285 B:B:Y264 47.09323.52NoYes065
102B:B:R283 B:B:V40 10.81179.15YesYes1893
103G:G:F61 G:G:P60 10.02234.33YesNo489
104B:B:M325 G:G:P60 14.5315.03NoNo059
105B:B:M325 G:G:P49 23.54516.71NoNo057
106G:G:D48 G:G:P49 24.28863.22YesNo097
107B:B:S281 G:G:D48 26.021510.31NoYes099
108B:B:G282 B:B:S281 26.26893.71YesNo099
109B:B:F278 B:B:G282 26.28463.01YesYes1279
110B:B:F222 B:B:Q220 13.38917.03NoNo087
111R:R:F92 R:R:I175 19.6983.77YesNo087
112L:L:W14 R:R:H376 10.17493.17YesYes205
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:H376 R:R:T111 4.11 2 Yes No 5 7 1 2
R:R:T111 R:R:Y380 8.74 2 No Yes 7 7 2 2
R:R:F120 R:R:P114 5.78 2 Yes No 8 5 1 1
L:L:?12 R:R:P114 5.9 2 Yes No 0 5 0 1
R:R:I372 R:R:N115 4.25 2 Yes No 4 5 1 2
L:L:?12 R:R:G118 4.91 2 Yes No 0 4 0 1
R:R:F120 R:R:F122 9.65 2 Yes Yes 8 6 1 2
R:R:C127 R:R:F120 5.59 2 No Yes 9 8 2 1
R:R:C205 R:R:F120 11.17 2 Yes Yes 9 8 1 1
L:L:?12 R:R:F120 7 2 Yes Yes 0 8 0 1
R:R:C127 R:R:V195 3.42 2 No No 9 4 2 2
R:R:C127 R:R:C205 7.28 2 No Yes 9 9 2 1
R:R:V138 R:R:W346 8.58 0 No Yes 7 8 1 2
L:L:F17 R:R:V138 3.93 0 No No 0 7 0 1
R:R:M186 R:R:Y189 3.59 2 Yes Yes 8 7 2 1
R:R:M186 R:R:W218 3.49 2 Yes Yes 8 7 2 2
R:R:P190 R:R:Y189 4.17 0 No Yes 6 7 2 1
R:R:H207 R:R:Y189 9.8 2 Yes Yes 5 7 1 1
R:R:W218 R:R:Y189 10.61 2 Yes Yes 7 7 2 1
L:L:D16 R:R:Y189 8.05 2 Yes Yes 0 7 0 1
L:L:F17 R:R:Y189 7.22 0 No Yes 0 7 0 1
R:R:H207 R:R:T193 6.85 2 Yes No 5 6 1 2
R:R:C205 R:R:V195 5.12 2 Yes No 9 4 1 2
R:R:V198 R:R:V202 4.81 2 No No 1 1 2 2
R:R:Q204 R:R:V198 5.73 2 No No 4 1 1 2
R:R:Q204 R:R:V202 7.16 2 No No 4 1 1 2
L:L:?12 R:R:Q204 14.34 2 Yes No 0 4 0 1
L:L:?12 R:R:C205 3.42 2 Yes Yes 0 9 0 1
L:L:M15 R:R:C205 4.86 2 No Yes 0 9 0 1
L:L:M15 R:R:H207 3.94 2 No Yes 0 5 0 1
L:L:D16 R:R:H207 8.82 2 Yes Yes 0 5 0 1
L:L:D16 R:R:N353 12.12 2 Yes No 0 7 0 1
R:R:A363 R:R:W355 3.89 0 No Yes 3 5 1 2
R:R:H364 R:R:R356 4.51 2 No No 1 4 1 1
L:L:W14 R:R:R356 12 2 Yes No 0 4 0 1
L:L:D16 R:R:R356 4.76 2 Yes No 0 4 0 1
R:R:G362 R:R:R365 4.5 0 No No 4 3 2 1
L:L:W14 R:R:A363 3.89 2 Yes No 0 3 0 1
L:L:G13 R:R:H364 3.18 0 No No 0 1 0 1
L:L:W14 R:R:H364 11.64 2 Yes No 0 1 0 1
R:R:G369 R:R:S368 3.71 0 No No 3 5 2 1
L:L:A11 R:R:S368 3.42 0 No No 0 5 0 1
R:R:I372 R:R:I375 4.42 2 Yes No 4 6 1 2
R:R:H376 R:R:I372 5.3 2 Yes Yes 5 4 1 1
L:L:W14 R:R:I372 19.97 2 Yes Yes 0 4 0 1
R:R:H376 R:R:Y380 11.98 2 Yes Yes 5 7 1 2
L:L:W14 R:R:H376 3.17 2 Yes Yes 0 5 0 1
L:L:E10 R:R:R365 2.33 0 No No 0 3 0 1
R:R:G118 R:R:T119 1.82 0 No No 4 4 1 2
R:R:L113 R:R:P114 1.64 0 No No 5 5 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
86.67Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
70.59Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
60.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
57.89Single7F8XNN90567F8X-CCKA-NN9056
55.56Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
55.56Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
55.56Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
55.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
55.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
52.94Consensuscck_onOrthosteric Ligandccka_on cckb_on
52.63Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
52.63Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
52.63Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
52.38Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
52.17Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
47.62Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
47.37Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
47.06Single5N2SPSB365N2S-A1-PSB36
47.06Single8GNEKW-63568GNE-A2A-KW-6356-Na
46.67Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
45.45Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
44.44Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
44.44Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
44.44Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
42.31Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
42.31Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
42.31Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
42.11Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.11Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.11Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
42.11Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
42.11Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
41.67Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
41.38Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
40.00Single7EZCUKA7EZC-A2A-UKA
40.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
40.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
39.13Single6PT2KGCHM076PT2-δ-KGCHM07
39.13Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
39.13Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
38.89Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
38.89Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
38.89Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
38.10Single5WF6UK-4320975WF6-A2A-UK-432097
38.10Single7XN9L-054,5227XN9-SST2-L-054,522
38.10Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
38.10Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
38.10Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
38.10Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.10Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.10Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
37.50Single5K2DZM2413855K2D-A2A-ZM241385
37.50Single6JZHZM2413856JZH-A2A-ZM241385-Na
37.50Single6PS7ZM2413856PS7-A2A-ZM241385-Na
37.50Single7F8ULintitript7F8U-CCKA-Lintitript
37.50Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
37.50Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
37.50Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
37.04Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
37.04Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
36.84Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
36.84Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
36.84Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
36.67Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
36.67Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
36.67Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
36.36Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
36.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.00Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
36.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
36.00Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
36.00Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.00Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71Single8A2OTheophylline8A2O-A2A-Theophylline-Na
35.71Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
35.71Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
35.29Single5IU4ZM2413855IU4-A2A-ZM241385-Na
35.29Single5IU7Q274563465IU7-A2A-Q27456346-Na
35.29Single5IUBQ274563445IUB-A2A-Q27456344-Na
35.29Single5JTBZM2413855JTB-A2A-ZM241385
35.29Single5K2BZM2413855K2B-A2A-ZM241385-Na
35.29Single5K2CZM2413855K2C-A2A-ZM241385-Na
35.29Single5NLXZM2413855NLX-A2A-ZM241385-Na
35.29Single5NM4ZM2413855NM4-A2A-ZM241385-Na
35.29Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
35.29Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
35.29Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
35.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
35.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
34.78Single3QAKUK-4320973QAK-A2A-UK-432097
34.78Single7SK5CXCL127SK5-ACKR3-CXCL12
34.78Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
34.78Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.62Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.62Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.62Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.62Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
33.33Single3EMLZM2413853EML-A2A-ZM241385
33.33Single4EIYZM2413854EIY-A2A-ZM241385-Na
33.33Single5IU8Q274563475IU8-A2A-Q27456347-Na
33.33Single5K2AZM2413855K2A-A2A-ZM241385-Na
33.33Single5OLGZM2413855OLG-A2A-ZM241385-Na
33.33Single5VRAZM2413855VRA-A2A-ZM241385-Na
33.33Single5WF5UK-4320975WF5-A2A-UK-432097
33.33Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
33.33Single6LPJZM2413856LPJ-A2A-ZM241385-Na
33.33Single6LPKZM2413856LPK-A2A-ZM241385-Na
33.33Single6S0LZM2413856S0L-A2A-ZM241385
33.33Single7PYRPSB-21157PYR-A2A-PSB-2115
33.33Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
33.33Single8CU6LJ-45178CU6-A2A-LJ-4517
33.33Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
33.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
33.33Consensusa2_offOrthosteric Liganda2a_off
33.33Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
33.33Consensusadenosine_onOrthosteric Liganda1_on a2_on
33.33Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
33.33Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
33.33Consensusnucleotide_onOrthosteric Ligandadenosine_on
33.33Consensusorexin_onOrthosteric Ligandox2_on
32.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
32.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
31.82Single4UG2CGS216804UG2-A2A-CGS21680
31.82Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
31.82Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
31.82Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
31.82Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
31.82Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
31.58Single5IUAQ274563485IUA-A2A-Q27456348-Na
31.58Single5NM2ZM2413855NM2-A2A-ZM241385-Na
31.58Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
31.58Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
31.58Single6LPLZM2413856LPL-A2A-ZM241385-Na
31.58Single6S0QZM2413856S0Q-A2A-ZM241385
31.58Single6WQAZM2413856WQA-A2A-ZM241385-Na
31.58Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
31.58Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
31.58Single7RM5ZM2413857RM5-A2A-ZM241385-Na
31.58Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
31.58Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
31.58Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
31.58Single8FYNZM2413858FYN-A2A-ZM241385-Na
31.58Single8QOTNanobody E8QOT-μ-Nanobody E
31.58Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
31.58Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
31.58Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
31.25Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
31.25Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
31.25Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
31.25Single8GH1Epinephrine8GH1-β2-Epinephrine
31.25Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
31.03Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
30.77Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
30.77Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
30.43Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
30.43Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
30.43Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
30.43Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.43Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
30.43Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
30.43Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
30.43Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
30.43Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
30.43Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
30.43Consensussst_onOrthosteric Ligandsst2_on sst4_on
30.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
30.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
30.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
30.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
30.00Single7PX4PSB-21137PX4-A2A-PSB-2113
30.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
30.00Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
30.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
30.00Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
30.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
30.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
30.00Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
30.00Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
30.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
30.00Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
29.63Single7SK3CXCL127SK3-ACKR3-CXCL12
29.63Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
29.63Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
29.63Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
29.41Single3PWHZM2413853PWH-A2A-ZM241385
29.41Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
29.41Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
29.41Single7F8YDevazepide7F8Y-CCKA-Devazepide
29.41Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
29.41Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
29.41Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
29.41Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
29.41Single8GNGIstradefylline8GNG-A2A-Istradefylline
29.41Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
29.41Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
29.41Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
29.41Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
29.41Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
29.17Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
29.17Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
29.17Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
29.17Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
29.17Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
29.17Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
29.17Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
28.57Single4XEENeurotensin4XEE-NTS1-Neurotensin
28.57Single4XESNeurotensin4XES-NTS1-Neurotensin
28.57Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
28.57Single6MXTSalmeterol6MXT-β2-Salmeterol
28.57Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
28.57Single6OS2TRV0266OS2-AT1-TRV026
28.57Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
28.57Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
28.57Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8JJLOlodaterol8JJL-β2-Olodaterol
28.57Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
28.57Single8PWNTheophylline8PWN-A2A-Theophylline
28.57Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Consensusendothelin_onOrthosteric Ligandetb_on eta_on
28.57Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
28.57Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
28.57Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
28.57Consensusgs_steroidOrthosteric Ligandgs_bileacid
28.57Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
28.12Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
28.00Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Consensusangiotensin_onOrthosteric Ligandat1_on
28.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
28.00Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
27.78Single2YDOAdenosine2YDO-A2A-Adenosine
27.78Single5UVIZM2413855UVI-A2A-ZM241385
27.78Single6AQFZM2413856AQF-A2A-ZM241385
27.78Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
27.78Single6MH8ZM2413856MH8-A2A-ZM241385
27.78Single6V9SGTPL114036V9S-OX1-GTPL11403
27.78Single6VI4JDTic6VI4-κ-JDTic
27.78Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
27.78Single6ZG9GSK10347026ZG9-M1-GSK1034702
27.78Single7AROLUF58337ARO-A2A-LUF5833-Na
27.78Single7T32ZM2413857T32-A2A-ZM241385
27.78Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
27.78Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Single6IGLIRL16206IGL-ETB-IRL1620
27.59Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
27.27Single4BUONeurotensin4BUO-NTS1-Neurotensin
27.27Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
27.27Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
27.27Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
27.27Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
27.27Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
27.27Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
27.27Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
27.27Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
27.27Consensussteroid_onOrthosteric Ligandbileacid_on
26.92Single6JODAngiotensin II6JOD-AT2-Angiotensin II
26.92Single7C61Ergotamine7C61-5-HT1B-Ergotamine
26.92Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
26.92Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
26.92Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
26.92Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
26.92Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
26.92Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
26.67Single3RFMCaffeine3RFM-A2A-Caffeine
26.67Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
26.32Single5UENDU1725UEN-A1-DU172
26.32Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
26.32Single6PS1Timolol6PS1-β2-Timolol
26.32Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
26.32Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
26.32Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
26.32Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
26.32Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
26.32Single7UL4Alvimopan7UL4-μ-Alvimopan
26.32Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
26.32Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
26.32Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
26.32Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
26.32Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
26.32Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Consensuscck_offOrthosteric Ligandccka_off
26.32Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
26.32Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
26.32Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
26.32Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
26.32Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
26.09Single3NY9PubChem 9131033NY9-β2-PubChem 913103
26.09Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
26.09Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
26.09Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
25.93Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
25.93Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.93Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.93Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
25.93Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
25.93Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.81Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.81Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
25.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
25.00Single4XNWMRS25004XNW-P2Y1-MRS2500
25.00Single4XT1Fractalkine4XT1-US28-Fractalkine
25.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
25.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
25.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
25.00Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
25.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
25.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
25.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
25.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
25.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
25.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
25.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
25.00Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
25.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
25.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
25.00Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
25.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
25.00Single7XKAEpinephrine7XKA-β2-Epinephrine
25.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
25.00Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
25.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
25.00Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
25.00Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
25.00Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
25.00Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
25.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
25.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
25.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
25.00Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
25.00Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
25.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
24.14Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
24.14Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
24.14Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
24.14Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
24.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
24.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
24.00Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
24.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
24.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single2YDVNECA2YDV-A2A-NECA
23.81Single3P0GBI1671073P0G-β2-BI167107
23.81Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
23.81Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
23.81Single4BV0Neurotensin4BV0-NTS1-Neurotensin
23.81Single4RWADIPP-NH24RWA-δ-DIPP-NH2
23.81Single4UHRCGS216804UHR-A2A-CGS21680
23.81Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
23.81Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
23.81Single5G53NECA5G53-A2A-NECA-Gs
23.81Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
23.81Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
23.81Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
23.81Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
23.81Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
23.81Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
23.81Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
23.81Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
23.81Single7TUYGSK682753A7TUY-GPR183-GSK682753A
23.81Single7W41PD1762527W41-BB2-PD176252
23.81Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
23.81Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
23.81Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
23.81Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
23.81Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
23.81Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
23.81Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
23.81Consensusbombesin_offOrthosteric Ligandbb2_off
23.81Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
23.81Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
23.81Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
23.81Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
23.81Consensuslpa_onOrthosteric Ligandlpa1_on
23.81Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
23.81Consensusrelaxin_onOrthosteric Ligandrxfp4_on
23.68Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
23.53Single3OE9IT1t3OE9-CXCR4-IT1t
23.53Single5L7IVismodegib5L7I-SMO-Vismodegib
23.53Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
23.53Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
23.53Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
23.53Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
23.53Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
23.53Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
23.53Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
23.53Single8K5BNiacin8K5B-HCA2-Niacin
23.53Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
23.33Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
23.33Single8IY6Endothelin-18IY6-ETB-Endothelin-1
23.33Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
23.33Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.08Single3OE0CVX153OE0-CXCR4-CVX15
23.08Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
23.08Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
23.08Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
23.08Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
23.08Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
23.08Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
23.08Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
22.73Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
22.73Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
22.73Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
22.73Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
22.73Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
22.73Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
22.73Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
22.73Single6YVRNTS8-136YVR-NTS1-NTS8-13
22.73Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
22.73Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
22.73Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
22.73Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.73Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single8JJ8Formoterol8JJ8-β2-Formoterol
22.73Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
22.73Single8JWZAB9288JWZ-A2A-AB928-Na
22.73Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
22.73Consensuschemokine_offOrthosteric Ligandcxcr_off
22.73Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
22.73Consensuscxcr_offOrthosteric Ligandcxcr4_off
22.73Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
22.73Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
22.73Consensusdp_offOrthosteric Liganddp2_off
22.73Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
22.73Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.73Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
22.73Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
22.73Consensusnts_onOrthosteric Ligandnts1_on
22.73Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.73Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
22.58Single5GLHEndothelin-15GLH-ETB-Endothelin-1
22.58Single6IGKEndothelin-36IGK-ETB-Endothelin-3
22.22Single3ODUIT1t3ODU-CXCR4-IT1t
22.22Single5DHHSB-6121115DHH-NOP-SB-612111
22.22Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
22.22Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
22.22Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
22.22Single6ME2Ramelteon6ME2-MT1-Ramelteon
22.22Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
22.22Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
22.22Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
22.22Single6TODEMPA6TOD-OX1-EMPA-Na
22.22Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
22.22Single7XRRLemborexant7XRR-OX2-Lemborexant
22.22Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
22.22Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
22.22Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8IWESpermidine8IWE-TAAR9-Spermidine
22.22Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
22.22Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
22.22Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
22.22Consensusmglu_onOther Ligandmglu2_on mglu4_on
22.22Consensusorexin_offOrthosteric Ligandox2_off ox1_off
22.22Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
21.88Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
21.88Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
21.74Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
21.74Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
21.74Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
21.74Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
21.74Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
21.74Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
21.74Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
21.74Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
21.74Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
21.74Single6H7LDobutamine6H7L-β1-Dobutamine
21.74Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
21.74Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
21.74Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
21.74Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
21.74Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
21.74Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.74Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
21.74Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
21.74Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
21.74Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
21.74Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
21.74Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
21.74Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Single5MZPCaffeine5MZP-A2A-Caffeine-Na
21.43Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
21.43Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
21.43Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
21.43Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
21.43Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
21.43Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
21.43Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
21.21Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
21.21Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
21.21Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
21.05Single3REYPubChem 56973REY-A2A-PubChem 5697
21.05Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
21.05Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
21.05Single4ZJCSB-6740424ZJC-OX1-SB-674042
21.05Single6PS4ICI 118-5516PS4-β2-ICI 118-551
21.05Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
21.05Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
21.05Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
21.05Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
21.05Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.05Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
21.05Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
21.05Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
21.05Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
21.05Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
21.05Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GGKEpinephrine8GGK-β2-Epinephrine
21.05Single8GGMEpinephrine8GGM-β2-Epinephrine
21.05Single8GGPEpinephrine8GGP-β2-Epinephrine
21.05Single8GGQEpinephrine8GGQ-β2-Epinephrine
21.05Single8GGTEpinephrine8GGT-β2-Epinephrine
21.05Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
21.05Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
21.05Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
21.05Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
21.05Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
21.05Single8K5CAcipimox8K5C-HCA2-Acipimox
21.05Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
21.05Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
21.05Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
21.05Consensusgnrh_offOrthosteric Ligandgnrh1_off
21.05Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
21.05Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
21.05Consensushca_onOrthosteric Ligandhca2_on hca3_on
21.05Consensushcar_onOrthosteric Ligandhca_on
21.05Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
21.05Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
21.05Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
20.83Single6PT3DPI-2876PT3-δ-DPI-287
20.83Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
20.83Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
20.83Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
20.83Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
20.83Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
20.83Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
20.83Consensuslpl_onOrthosteric Ligands1p_on lpa_on
20.83Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
20.83Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
20.83Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
20.69Single4XT3Fractalkine4XT3-US28-Fractalkine
20.69Single6FJ3PTH6FJ3-PTH1-PTH
20.69Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
20.69Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
20.69Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
20.59Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.00Single3NY8ICI 118-5513NY8-β2-ICI 118-551
20.00Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
20.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
20.00Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
20.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
20.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
20.00Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
20.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
20.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
20.00Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
20.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
20.00Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
20.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
20.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
20.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
20.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
20.00Single6D27CAY104716D27-DP2-CAY10471
20.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
20.00Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
20.00Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
20.00Single6TOTLemborexant6TOT-OX1-Lemborexant
20.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
20.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
20.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
20.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
20.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
20.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
20.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
20.00Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
20.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
20.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
20.00Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
20.00Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
20.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
20.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
20.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
20.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
20.00Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
20.00Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
20.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
20.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
20.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
20.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
20.00Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GGJEpinephrine8GGJ-β2-Epinephrine
20.00Single8GGNEpinephrine8GGN-β2-Epinephrine
20.00Single8GGOEpinephrine8GGO-β2-Epinephrine
20.00Single8GGUEpinephrine8GGU-β2-Epinephrine
20.00Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
20.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
20.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
20.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
20.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
20.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
20.00Single8JJOAlprenolol8JJO-β2-Alprenolol
20.00Single8K5DGSK2560738K5D-HCA2-GSK256073
20.00Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
20.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
20.00Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
20.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
20.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
20.00Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
20.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
20.00Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
20.00Consensusgi_hcarOrthosteric Ligandgi_hca
20.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
20.00Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
20.00Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
20.00Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
20.00Consensushcar_offOrthosteric Ligandsuccinate_off
20.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
20.00Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
20.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
20.00Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
19.35Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
19.35Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
19.35Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
19.35Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
19.35Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
19.35Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
19.35Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
19.23Single6HLOAprepitant6HLO-NK1-Aprepitant
19.23Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
19.23Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
19.23Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
19.23Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
19.23Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
19.23Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
19.23Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
19.23Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
19.05Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
19.05Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
19.05Single5C1MBU725C1M-μ-BU72
19.05Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
19.05Single5TVNLSD5TVN-5-HT2B-LSD
19.05Single5WQCEMPA5WQC-OX2-EMPA
19.05Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
19.05Single6D26Fevipiprant6D26-DP2-Fevipiprant
19.05Single6E67BI1671076E67-β2-BI167107-Gs (fused)
19.05Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
19.05Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
19.05Single6LUQHaloperidol6LUQ-D2-Haloperidol
19.05Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
19.05Single6PS6Timolol6PS6-β2-Timolol
19.05Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
19.05Single6TP6Filorexant6TP6-OX1-Filorexant
19.05Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
19.05Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
19.05Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
19.05Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
19.05Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
19.05Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
19.05Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
19.05Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
19.05Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
19.05Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
19.05Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
19.05Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
19.05Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
19.05Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
19.05Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
19.05Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
19.05Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
19.05Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
19.05Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
19.05Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
19.05Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
19.05Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
19.05Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
19.05Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
19.05Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
19.05Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
18.75Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
18.75Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
18.52Single6W25SHU91196W25-MC4-SHU9119-Ca
18.52Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
18.52Single7XNACYN1548067XNA-SST2-CYN154806
18.52Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
18.52Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
18.52Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
18.52Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
18.18Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
18.18Single4DJHJDTic4DJH-κ-JDTic
18.18Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
18.18Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
18.18Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
18.18Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
18.18Single5V56TC1145V56-SMO-TC114
18.18Single5XR8AM8415XR8-CB1-AM841
18.18Single5XRAAM115425XRA-CB1-AM11542
18.18Single6H7JIsoprenaline6H7J-β1-Isoprenaline
18.18Single6J20Aprepitant6J20-NK1-Aprepitant
18.18Single6J21Aprepitant6J21-NK1-Aprepitant
18.18Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
18.18Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
18.18Single6OS1TRV0266OS1-AT1-TRV026
18.18Single6TQ7SB-3348676TQ7-OX1-SB-334867
18.18Single6WGTLSD6WGT-5-HT2A-LSD
18.18Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
18.18Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
18.18Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
18.18Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
18.18Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
18.18Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
18.18Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
18.18Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
18.18Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
18.18Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
18.18Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
18.18Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
18.18Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
18.18Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
18.18Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
18.18Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
18.18Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
18.18Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
18.18Single8E0GBU728E0G-μ-BU72
18.18Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
18.18Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
18.18Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
18.18Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
18.18Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
18.18Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
18.18Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
18.18Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
18.18Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
18.18Consensus5ht5_offOrthosteric Ligand5ht5a_off
18.18Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
18.18Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
18.18Consensuschemerin_onOrthosteric Ligandcml1_on
18.18Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
18.18Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
18.18Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
18.18Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
18.18Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
18.18Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
18.18Consensuslpa_offOrthosteric Ligandlpa1_off
18.18Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
18.18Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
17.86Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
17.86Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
17.86Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
17.86Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
17.86Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
17.86Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.86Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single3OE6IT1t3OE6-CXCR4-IT1t
17.65Single3OE8IT1t3OE8-CXCR4-IT1t
17.65Single3UZAGTPL92363UZA-A2A-GTPL9236
17.65Single6ME5Agomelatine6ME5-MT1-Agomelatine
17.65Single6ME9Ramelteon6ME9-MT2-Ramelteon
17.65Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
17.65Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
17.65Single8GGREpinephrine8GGR-β2-Epinephrine
17.65Single8GGZEpinephrine8GGZ-β2-Epinephrine
17.65Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
17.65Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
17.39Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
17.39Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
17.39Single4AMIBucindolol4AMI-β1-Bucindolol
17.39Single4LDEBI1671074LDE-β2-BI167107
17.39Single4N4WSANT-14N4W-SMO-SANT-1
17.39Single4PY02MeSATP4PY0-P2Y12-2MeSATP
17.39Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
17.39Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
17.39Single6CM4Risperidone6CM4-D2-Risperidone
17.39Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
17.39Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
17.39Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
17.39Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
17.39Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
17.39Single6ZG4HTL00099366ZG4-M1-HTL0009936
17.39Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
17.39Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
17.39Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
17.39Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
17.39Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
17.39Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
17.39Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
17.39Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
17.39Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
17.39Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
17.39Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
17.39Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
17.39Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
17.39Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
17.39Single7YITNalfurafine7YIT-κ-Nalfurafine
17.39Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
17.39Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
17.39Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
17.39Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
17.39Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
17.39Single8WU1KCA8WU1-CB1-KCA-Arrestin1
17.39Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
17.39Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
17.39Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
17.39Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
17.39Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
17.39Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
17.39Consensusclass-b2_onOrthosteric Ligandadgrg_on
17.39Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
17.39Consensusgi_class-fOther Ligandgi_frizzled
17.39Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
17.39Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
17.39Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
17.39Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
17.39Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
17.39Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
17.39Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
17.39Consensusnts_offOrthosteric Ligandnts1_off
17.39Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
17.24Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
17.24Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
17.24Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
17.24Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
17.24Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
17.14Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
17.14Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
17.14Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
16.67Single4O9RCyclopamine4O9R-SMO-Cyclopamine
16.67Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
16.67Single6HLLCP999946HLL-NK1-CP99994
16.67Single6IBLArformoterol6IBL-β1-Arformoterol
16.67Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
16.67Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
16.67Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
16.67Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
16.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
16.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
16.67Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
16.67Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
16.67Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
16.67Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
16.67Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7SRQLSD7SRQ-5-HT2B-LSD
16.67Single7UL2SR486927UL2-NTS1-SR48692-Na
16.67Single7UM4AS26747237UM4-5-HT5A-AS2674723
16.67Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
16.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
16.67Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
16.67Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
16.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
16.67Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
16.67Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
16.67Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
16.67Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GGSEpinephrine8GGS-β2-Epinephrine
16.67Single8GGYEpinephrine8GGY-β2-Epinephrine
16.67Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
16.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
16.67Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
16.67Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
16.67Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.67Consensusendothelin_offOrthosteric Ligandetb_off
16.67Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
16.67Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
16.67Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
16.67Consensusgo_proteinOrthosteric Ligandgo_chemokine
16.67Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
16.67Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
16.67Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
16.67Consensuspth_onOrthosteric Ligandpth1_on pth2_on
16.67Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
16.13Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
16.13Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
16.13Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
16.13Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
16.13Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
16.13Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.00Single5EE7MK08935EE7-Glucagon-MK0893
16.00Single5ZTYAM102575ZTY-CB2-AM10257
16.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
16.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
16.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
16.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
16.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
16.00Single8X5YAstemizole8X5Y-H1-Astemizole
16.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
16.00Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
16.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
16.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
16.00Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
16.00Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Consensusgs_class-b2Orthosteric Ligandgs_adgr
16.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
15.79Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
15.79Single4BWBNeurotensin4BWB-NTS1-Neurotensin
15.79Single4QINSAG1.54QIN-SMO-SAG1.5
15.79Single4S0VSuvorexant4S0V-OX2-Suvorexant
15.79Single5WS3EMPA5WS3-OX2-EMPA
15.79Single6AKXA4R6AKX-CCR5-A4R
15.79Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
15.79Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
15.79Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
15.79Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
15.79Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
15.79Single6TPJSuvorexant6TPJ-OX2-Suvorexant
15.79Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
15.79Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.79Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
15.79Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
15.79Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
15.79Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
15.79Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
15.79Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
15.79Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
15.79Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
15.79Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
15.79Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
15.79Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
15.79Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
15.79Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
15.79Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
15.79Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
15.79Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
15.79Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8GGVEpinephrine8GGV-β2-Epinephrine
15.79Single8GGWEpinephrine8GGW-β2-Epinephrine
15.79Single8GGXEpinephrine8GGX-β2-Epinephrine
15.79Single8GH0Epinephrine8GH0-β2-Epinephrine
15.79Single8IHKAcifran8IHK-HCA3-Acifran
15.79Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
15.79Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
15.79Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
15.79Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
15.79Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
15.79Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
15.79Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
15.79Consensusclass-f_offOrthosteric Ligandsmo_off
15.79Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.79Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.62Single6LMLGlucagon6LML-Glucagon-Glucagon
15.62Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
15.62Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.38Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
15.38Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
15.38Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
15.38Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
15.15Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
15.15Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
15.15Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
15.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
15.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
15.00Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
15.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
15.00Single6IQLL7458706IQL-D4-L745870
15.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
15.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
15.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
15.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
15.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
15.00Single6TPGEMPA6TPG-OX2-EMPA
15.00Single6TPKRetosiban6TPK-OT-Retosiban
15.00Single6TPNHTL66416TPN-OX2-HTL6641
15.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
15.00Single6ZINSR486926ZIN-NTS1-SR48692
15.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
15.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
15.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
15.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
15.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
15.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
15.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
15.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
15.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
15.00Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
15.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
15.00Single7VV6C48/807VV6-MRGPRX2-C48/80
15.00Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
15.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
15.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
15.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
15.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
15.00Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8GGIEpinephrine8GGI-β2-Epinephrine
15.00Single8GGLEpinephrine8GGL-β2-Epinephrine
15.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
15.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
15.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
15.00Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
15.00Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
15.00Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
15.00Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
15.00Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
15.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
15.00Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
15.00Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
15.00Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
15.00Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
15.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
15.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
15.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.00Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
15.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
15.00Consensusvasopressin-ot_offOrthosteric Ligandot_off
14.81Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
14.81Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
14.81Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
14.81Consensussst_offOrthosteric Ligandsst2_off
14.81Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
14.71Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
14.71Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
14.71Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
14.71Consensusglp_onOrthosteric Ligandglp1_on glp2_on
14.63Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
14.29Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
14.29Single2Y02Carmoterol2Y02-β1-Carmoterol
14.29Single2Y04Salbutamol2Y04-β1-Salbutamol
14.29Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
14.29Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
14.29Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
14.29Single4YAYZD-71554YAY-AT1-ZD-7155
14.29Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
14.29Single5T04Neurotensin5T04-NTS1-Neurotensin
14.29Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
14.29Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
14.29Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
14.29Single6H7MSalbutamol6H7M-β1-Salbutamol
14.29Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
14.29Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
14.29Single7BU7BI1671077BU7-β1-BI167107
14.29Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
14.29Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
14.29Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
14.29Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
14.29Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
14.29Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
14.29Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
14.29Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
14.29Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
14.29Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
14.29Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
14.29Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
14.29Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
14.29Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
14.29Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single7WC7Lisuride7WC7-5-HT2A-Lisuride
14.29Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
14.29Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
14.29Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
14.29Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
14.29Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
14.29Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
14.29Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
14.29Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
14.29Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
14.29Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
14.29Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
14.29Single8X63Mepyramine8X63-H1-Mepyramine
14.29Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
14.29Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
14.29Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
14.29Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
14.29Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
14.29Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
14.29Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
14.29Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
14.29Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
14.29Consensusblt_onOrthosteric Ligandblt1_on
14.29Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
14.29Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
14.29Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
14.29Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
14.29Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
14.29Consensusleuko_onOrthosteric Ligandblt_on
14.29Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
14.29Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
14.29Consensustachykinin_offOrthosteric Ligandnk1_off
14.29Consensustar_onOrthosteric Ligandta1_on
13.89Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
13.89Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
13.79Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
13.79Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
13.79Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
13.79Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
13.79Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
13.79Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
13.79Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
13.64Single2Y00Dobutamine2Y00-β1-Dobutamine
13.64Single2Y03Isoprenaline2Y03-β1-Isoprenaline
13.64Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
13.64Single4NTJAZD12834NTJ-P2Y12-AZD1283
13.64Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
13.64Single5WIUNemonapride5WIU-D4-Nemonapride
13.64Single5WIVNemonapride5WIV-D4-Nemonapride-Na
13.64Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
13.64Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
13.64Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
13.64Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
13.64Single6Z4SSR486926Z4S-NTS1-SR48692
13.64Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
13.64Single7C4SS1P7C4S-S1P3-S1P
13.64Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
13.64Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
13.64Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
13.64Single7SINNPS-21437SIN-CaS-NPS-2143
13.64Single7SINNPS-21437SIN-CaS-NPS-2143
13.64Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
13.64Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
13.64Single7WC6LSD7WC6-5-HT2A-LSD
13.64Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
13.64Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
13.64Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
13.64Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
13.64Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
13.64Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
13.64Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
13.64Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
13.64Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
13.64Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
13.64Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
13.64Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
13.64Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
13.64Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
13.64Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
13.51Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
13.33Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.33Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
13.33Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
13.04Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
13.04Single5TZR-5TZR-FFA1 (GPR40)-MK8666
13.04Single5V57TC1145V57-SMO-TC114
13.04Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
13.04Single6E59L-7607356E59-NK1-L-760735
13.04Single7B6WCyclazosin7B6W-α1b-Cyclazosin
13.04Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
13.04Single7EPENAM5637EPE-mGlu-NAM563
13.04Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
13.04Single7F1TMIP-1a7F1T-CCR5-MIP-1a
13.04Single7P2L4YI7P2L-mGlu5-4YI
13.04Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
13.04Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
13.04Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
13.04Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
13.04Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
13.04Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
13.04Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
13.04Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
13.04Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
13.04Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
13.04Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
13.04Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
13.04Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
13.04Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
13.04Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
13.04Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
13.04Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
13.04Consensushistamine_offOrthosteric Ligandh1_off
13.04Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
13.04Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
12.90Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
12.82Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
12.82Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
12.50Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
12.50Single6A93Risperidone6A93-5-HT2A-Risperidone
12.50Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
12.50Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
12.50Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
12.50Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
12.50Single7DFPSpiperone7DFP-D2-Spiperone
12.50Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
12.50Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
12.50Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
12.50Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
12.50Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
12.50Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
12.50Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
12.50Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
12.50Consensusclass-c_onOther Ligandgabab_on mglu_on
12.50Consensusgo_class-b1Orthosteric Ligandgo_crf
12.50Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
12.50Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
12.50Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
12.20Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
12.12Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
12.12Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
12.12Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
12.12Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
12.12Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
12.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
12.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
12.00Single6K1QIRL25006K1Q-ETB-IRL2500
12.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
12.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
12.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
12.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
12.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
12.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
12.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
12.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
12.00Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single6TQ9SB-4081246TQ9-OX1-SB-408124
11.76Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.76Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
11.76Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
11.76Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
11.76Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
11.54Single6KNMJN241-96KNM-Apelin-JN241-9
11.54Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
11.54Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
11.54Consensusclass-d_offOrthosteric Ligandste2_off
11.11Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
11.11Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
11.11Single6LI0GTPL98046LI0-GPR52-GTPL9804
11.11Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
11.11Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
11.11Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
11.11Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
11.11Single7QA8Peptide7QA8-STE2-Peptide
11.11Single7QA8Peptide7QA8-STE2-Peptide
11.11Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
11.11Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
11.11Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
11.11Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
11.11Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
11.11Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
11.11Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusclass-d_offOrthosteric Ligandste2_off
11.11Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
10.71Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.71Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
10.71Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single3PBLEticlopride3PBL-D3-Eticlopride
10.53Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
10.53Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
10.53Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
10.53Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
10.53Single6TP4ACT-4622066TP4-OX1-ACT-462206
10.53Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.53Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
10.53Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
10.53Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.53Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
10.53Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
10.53Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
10.53Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
10.53Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
10.53Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
10.53Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
10.53Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Consensusclass-t_onOrthosteric Ligandtaste2_on
10.53Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
10.53Consensusgs_class-tOrthosteric Ligandgs_taste
10.53Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.53Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
10.53Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.53Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.34Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.26Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.00Single5U09Taranabant5U09-CB1-Taranabant
10.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
10.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
10.00Single6B73PubChem 1319551386B73-κ-PubChem 131955138
10.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
10.00Single6KUXRS-799486KUX-α2a-RS-79948
10.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
10.00Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
10.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
10.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
10.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
10.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
10.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
10.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
10.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
10.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
10.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
10.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
10.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
10.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
10.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
10.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
10.00Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
10.00Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
10.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
10.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
10.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
10.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
10.00Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
10.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
10.00Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
10.00Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensusgt_class-aOrthosteric Ligandgt_opsin
10.00Consensusgt_opsinOrthosteric Ligandgt_sensory
10.00Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
10.00Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
10.00Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
9.76Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
9.68Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
9.52Single3RZECidoxepin3RZE-H1-Cidoxepin
9.52Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
9.52Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
9.52Single6A94Zotepine6A94-5-HT2A-Zotepine
9.52Single6DS0Ly2660976DS0-5-HT2B-Ly266097
9.52Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
9.52Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
9.52Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
9.52Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
9.52Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
9.52Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
9.52Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.52Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
9.52Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
9.52Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
9.52Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
9.52Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
9.52Single8K2WAMG4878K2W-CXCR3-AMG487
9.52Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.52Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
9.52Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
9.52Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
9.52Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
9.52Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
9.52Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
9.52Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
9.52Consensuss1p_offOrthosteric Ligands1p1_off
9.38Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
9.38Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Consensusclass-d_onOrthosteric Ligandste2_on
9.09Single2Y01Dobutamine2Y01-β1-Dobutamine
9.09Single4DAJTiotropium4DAJ-M3-Tiotropium
9.09Single4MQSIperoxo4MQS-M2-Iperoxo
9.09Single4U14Tiotropium4U14-M3-Tiotropium
9.09Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
9.09Single5DSGTiotropium5DSG-M4-Tiotropium
9.09Single5TGZAM65385TGZ-CB1-AM6538
9.09Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
9.09Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
9.09Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
9.09Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
9.09Single6DRXLisuride6DRX-5-HT2B-Lisuride
9.09Single6IIVDaltroban6IIV-TP-Daltroban
9.09Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
9.09Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
9.09Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
9.09Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
9.09Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
9.09Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
9.09Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
9.09Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
9.09Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
9.09Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
9.09Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
9.09Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.09Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.09Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
9.09Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
9.09Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8X64Desloratadine8X64-H1-Desloratadine
9.09Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
9.09Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
9.09Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Consensusgi_class-dOrthosteric Ligandgi_ste
9.09Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
9.09Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
9.09Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
9.09Consensushistamine_onOrthosteric Ligandh1_on h4_on
9.09Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
9.09Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
9.09Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
9.09Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
9.09Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
9.09Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
9.09Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
8.82Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
8.82Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
8.82Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
8.70Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
8.70Single5CGCHTL142425CGC-mGlu5-HTL14242
8.70Single5XPRBosentan5XPR-ETB-Bosentan
8.70Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
8.70Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
8.70Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
8.70Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
8.70Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
8.70Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
8.70Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
8.70Single7YXAONO-54306087YXA-S1P5-ONO-5430608
8.70Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single8EA0Iperoxo8EA0-M3-Iperoxo
8.70Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
8.70Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
8.70Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
8.70Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
8.70Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
8.70Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
8.70Consensusep_offOrthosteric Ligandep4_off
8.70Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
8.70Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
8.70Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
8.70Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single4U15Tiotropium4U15-M3-Tiotropium
8.33Single5V54Methiothepin5V54-5-HT1B-Methiothepin
8.33Single5X93K-87945X93-ETB-K-8794
8.33Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
8.33Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
8.33Single6OL9Tiotropium6OL9-M5-Tiotropium
8.33Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
8.33Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
8.33Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
8.33Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
8.33Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
8.33Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
8.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Consensus5ht1_offOrthosteric Ligand5ht1b_off
8.33Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
8.33Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
8.33Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
8.33Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
8.33Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
8.33Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
8.00Single5CXVTiotropium5CXV-M1-Tiotropium
8.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
8.00Single6HLPNetupitant6HLP-NK1-Netupitant
8.00Single6IIURamatroban6IIU-TP-Ramatroban
8.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
8.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
8.00Single7K15MKD0467K15-BLT1-MKD046-Na
8.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
8.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
8.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
8.00Consensusblt_offOrthosteric Ligandblt1_off
8.00Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
8.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
7.69Single5CGDHTL142425CGD-mGlu5-HTL14242
7.69Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
7.69Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
7.69Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
7.69Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
7.69Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
7.69Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
7.69Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensusclass-c_offOther Ligandgabab_off mglu_off
7.69Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
7.69Consensuscyslt_offOrthosteric Ligandcyslt2_off
7.41Single7SK9CCX6627SK9-ACKR3-CCX662
7.14Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
7.14Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
7.14Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
6.90Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
6.25Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.25Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
6.25Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
5.88Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.56Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.56Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.56Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
5.56Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
5.56Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
5.56Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
5.56Consensussensory_onOrthosteric Ligandopsin_on
5.26Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
5.26Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.26Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
5.26Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
5.26Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
5.26Single7WC5Psilocin7WC5-5-HT2A-Psilocin
5.26Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.26Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
5.26Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.26Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
5.26Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
5.26Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.26Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.00Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
5.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
5.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
5.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.00Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.00Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
5.00Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.00Consensusgo_class-b2Orthosteric Ligandgo_adhesion
5.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
5.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
5.00Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
4.76Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
4.76Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
4.76Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
4.76Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
4.76Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single8G94CD698G94-S1P1-CD69-Gi1/&β;1/&γ;2
4.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.76Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
4.76Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.55Single6FFIMMPEP6FFI-mGlu5-MMPEP
4.55Single7VODCariprazine7VOD-5-HT2A-Cariprazine
4.55Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.55Consensussensory_offOrthosteric Ligandopsin_off
4.35Single6FFHFenobam6FFH-mGlu5-Fenobam
4.35Single6GPSMK08126GPS-CCR2-MK0812
4.35Single7F83PF-051904577F83-Ghrelin-PF-05190457
4.35Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
4.17Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
4.17Single6GPXMK08126GPX-CCR2-MK0812
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
4.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
4.00Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
4.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.85Single5X33BIIL2605X33-BLT1-BIIL260
3.85Single7SHEPI; PE7SHE-GPR158-PI; PE
3.85Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.70Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
3.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.70Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
3.45Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
3.33Single7SHEPI; PE7SHE-GPR158-PI; PE
3.33Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.12Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.12Consensusclass-d_onOrthosteric Ligandste2_on
3.12Consensusgi_class-dOrthosteric Ligandgi_ste
3.12Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
2.78Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.70Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.70Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.70Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.70Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
2.63Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.56Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.50Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.50Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.38Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.27Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.22Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.13Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 7XOX
Class A
SubFamily Peptide
Type Cholecystokinin
SubType CCKB
Species Homo sapiens
Ligand Cholecystokinin-8
Other Ligand(s) -
Protein Partners Gq/Beta1/Gamma2
PDB Resolution 3.1
Date 2022-07-20
D.O.I. 10.1038/s41421-022-00420-3
Net Summary
Imin 3
Number of Linked Nodes 839
Number of Links 978
Number of Hubs 134
Number of Links mediated by Hubs 515
Number of Communities 27
Number of Nodes involved in Communities 200
Number of Links involved in Communities 269
Path Summary
Number Of Nodes in MetaPath 113
Number Of Links MetaPath 112
Number of Shortest Paths 4212117
Length Of Smallest Path 3
Average Path Length 43.9636
Length of Longest Path 71
Minimum Path Strength 1.16
Average Path Strength 6.03155
Maximum Path Strength 22.68
Minimum Path Correlation 0.7
Average Path Correlation 0.993077
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.0303
Average % Of Corr. Nodes 32.5485
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.9286
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .
CodeTYS
PDB ResiduesL:L:?12
Environment DetailsOpen EMBL-EBI Page
CodeTYS
NameO-SULFO-L-TYROSINE
Synonyms
Identifier(2S)-2-azanyl-3-(4-sulfooxyphenyl)propanoic acid
FormulaC9 H11 N O6 S
Molecular Weight261.252
SMILESc1cc(ccc1C[C@@H](C(=O)O)N)OS(=O)(=O)O
PubChem514186
Formal Charge0
Total Atoms28
Total Chiral Atoms1
Total Bonds28
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP32239
Sequence
>7XOX_Chain_R
ELAIRITLY AVIFLMSVG GNMLIIVVL GLSRRLRTV TNAFLLSLA 
VSDLLLAVA CMPFTLLPN LMGTFIFGT VICKAVSYL MGVSVSVST 
LSLVAIALE RYSAICRPL QARVWQTRS HAARVIVAT WLLSGLLMV 
PYPVYTVVQ PVGPRVLQC VHRWPSARV RQTWSVLLL LLLFFIPGV 
VMAVAYGLI SRELYLGKL LAKKRVVRM LLVIVVLFF LCWLPVYSA 
NTWRAFDGP GAHRALSGA PISFIHLLS YASACVNPL VYCFMHRRF 
RQACLE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7XOX_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7XOX_Chain_G
QARKLVEQL KMEANIDRI KVSKAAADL MAYCEAHAK EDPLLTPVP 
ASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP50148
Sequence
>7XOX_Chain_A
LSAEDKAAV ERSKMIDRN LREDGEKAR RELKLLLLG TGESGKSTF 
IKQMRIIHG GIIEYPFDL QSVIFRMVD VGGQRSERR KWIHCFENV 
TSIMFLVAL SEYDQVNRM EESKALFRT IITYPWFQN SSVILFLNK 
KDLLEEKIM YSHLVDYFP EYDGPQRDA QAAREFILK MFVDLNPDS 
DKIIYSHFT CATDTENIR FVFAAVKDT ILQLNLKEY NLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F8VAPeptideCholecystokininCCKBHomo sapiensGastrin-17-Gi2/&β;1/&γ;23.32021-10-1310.1038/s41589-021-00866-8
7F8WAPeptideCholecystokininCCKBHomo sapiensGastrin-17-chim(NtGsL-Gq)/&β;1/&γ;23.12021-10-1310.1038/s41589-021-00866-8
7XOWAPeptideCholecystokininCCKBHomo sapiensGastrin-Gq/&β;1/&γ;23.12022-07-2010.1038/s41421-022-00420-3
8IA7APeptideCholecystokininCCKBHomo sapiensCholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;23.12023-12-0610.1038/s41421-022-00420-3




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