psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	1x30	1x34	4.69	No	No	0	2	5
2	1x32	2x66	13.92	No	Yes	0	5	5
3	1x32	E1.H131	5.24	No	No	0	5	3
4	1x35	1x39	5.05	No	Yes	0	5	7
5	1x36	2x61	4.42	No	No	0	6	6
6	1x36	2x66	9.7	No	Yes	0	6	5
7	1x39	2x57	8.38	Yes	Yes	1	7	8
8	1x39	2x60	6.73	Yes	Yes	1	7	6
9	1x39	2x61	4.69	Yes	No	0	7	6
10	1x39	7x42	8.94	Yes	Yes	1	7	7
11	1x42	7x43	2.98	No	No	0	7	5
12	1x43	1x47	7.78	No	No	0	7	6
13	1x45	7x47	3.17	No	No	0	6	7
14	1x46	7x47	3.64	No	No	0	8	7
15	1x49	7x50	4.06	No	Yes	0	9	9
16	1x50	2x47	4.69	Yes	No	0	9	9
17	1x50	2x50	12.12	Yes	No	0	9	9
18	1x50	2x51	4.12	Yes	No	0	9	7
19	1x50	7x50	6.52	Yes	Yes	0	9	9
20	1x51	2x51	2.95	No	No	0	4	7
21	1x52	1x56	4.76	Yes	Yes	2	6	7
22	1x52	8x54	10.49	Yes	Yes	2	6	7
23	1x52	8x57	3.17	Yes	Yes	2	6	5
24	1x52	8x58	4.47	Yes	No	2	6	7
25	1x53	1x57	2.95	No	No	0	9	7
26	1x53	7x50	3.5	No	Yes	0	9	9
27	1x54	2x47	3.15	No	No	0	8	9
28	1x56	8x50	3.89	Yes	Yes	2	7	8
29	1x56	8x53	3.04	Yes	No	0	7	6
30	1x56	8x54	5.19	Yes	Yes	2	7	7
31	1x56	8x57	4.71	Yes	Yes	2	7	5
32	1x57	2x40	7.71	No	No	0	7	8
33	1x59	8x53	13.78	No	No	0	5	6
34	1x59	8x57	6.47	No	Yes	0	5	5
35	2x37	2x41	3.82	No	Yes	5	8	5
36	2x37	4x39	5.27	No	No	5	8	3
37	2x38	3x49	4.23	No	Yes	0	7	8
38	2x41	4x39	7.2	Yes	No	5	5	3
39	2x41	4x42	7.49	Yes	No	0	5	7
40	2x41	4x43	5.97	Yes	No	5	5	3
41	2x42	3x45	6.97	No	No	0	8	7
42	2x42	3x46	12.86	No	No	0	8	9
43	2x43	7x53	15.24	No	Yes	0	8	9
44	2x45	3x42	8.94	No	No	0	9	8
45	2x45	4x46	3.1	No	No	0	9	7
46	2x45	4x50	6.18	No	Yes	0	9	9
47	2x46	3x42	5.49	No	No	0	9	8
48	2x46	7x49	4.12	No	Yes	0	9	9
49	2x49	3x35	3.44	Yes	No	0	8	7
50	2x49	3x38	3.42	Yes	No	4	8	7
51	2x49	3x39	4.8	Yes	No	4	8	9
52	2x49	4x50	3.71	Yes	Yes	4	8	9
53	2x49	Na	5.94	Yes	No	4	8	0
54	2x50	7x46	7.36	No	No	0	9	9
55	2x50	Na	10.74	No	No	0	9	0
56	2x53	3x35	3.38	No	No	0	7	7
57	2x53	7x41	3.89	No	Yes	0	7	7
58	2x53	7x46	4.8	No	No	0	7	9
59	2x54	7x46	3	No	No	0	7	9
60	2x57	2x58	3.35	Yes	No	0	8	9
61	2x57	7x42	16.76	Yes	Yes	1	8	7
62	2x59	E1x52	3.93	No	Yes	0	6	7
63	2x59	3x28	7.57	No	Yes	0	6	6
64	2x60	2x65	4.1	Yes	No	0	6	4
65	2x60	3x32	4.65	Yes	No	0	6	7
66	2x60	7x38	3.94	Yes	No	1	6	6
67	2x60	7x42	10.1	Yes	Yes	1	6	7
68	2x62	2x63	8.14	Yes	Yes	3	5	5
69	2x62	2x67	6.31	Yes	No	3	5	5
70	2x62	E1x52	6.19	Yes	Yes	3	5	7
71	2x63	2x67	2.96	Yes	No	3	5	5
72	2x63	E1x50	14.69	Yes	Yes	3	5	8
73	2x63	E1x52	9.67	Yes	Yes	3	5	7
74	2x64	3x28	7.22	No	Yes	0	4	6
75	2x65	2x66	8.22	No	Yes	0	4	5
76	E1.H132	E1x49	7.63	No	No	0	4	5
77	E1.H132	E2.G221	3.18	No	No	0	4	2
78	E1.H132	E2.V223	4.15	No	No	0	4	4
79	E1x50	E1x52	12.03	Yes	Yes	3	8	7
80	3x25	E1x50	3.92	No	Yes	3	9	8
81	E1x50	E2x50	6.53	Yes	No	3	8	9
82	3x21	E2.E209	3.27	No	No	0	8	5
83	3x22	3x26	10.72	No	No	0	3	7
84	3x22	E2.E209	6.5	No	No	0	3	5
85	3x25	E2x50	7.28	No	No	3	9	9
86	3x28	3x29	12.91	Yes	No	0	6	4
87	3x28	3x32	13.38	Yes	No	0	6	7
88	3x29	4x61	3.59	No	No	0	4	5
89	3x29	4x65	10.78	No	No	0	4	6
90	3x30	4x62	10.96	Yes	No	0	6	5
91	3x31	3x35	3.17	No	No	0	5	7
92	3x32	7x41	17.1	No	Yes	0	7	7
93	3x33	4x61	8.32	No	No	0	5	5
94	3x36	5x461	3.2	No	Yes	0	7	6
95	3x36	6x48	4.85	No	Yes	0	7	8
96	3x37	4x56	17.58	Yes	No	0	7	6
97	3x37	5x43	9.3	Yes	No	1	7	6
98	3x37	5x46	3.59	Yes	No	0	7	5
99	3x37	5x461	3.82	Yes	Yes	1	7	6
100	3x38	4x50	3.89	No	Yes	4	7	9
101	3x38	4x53	3.42	No	No	0	7	8
102	3x39	Na	8.75	No	No	4	9	0
103	3x44	5x54	3.25	No	No	0	8	8
104	3x45	4x45	5.28	No	No	7	7	6
105	3x45	4x49	3.1	No	Yes	7	7	7
106	3x46	6x37	2.98	No	No	0	9	8
107	3x47	5x54	6.19	No	No	0	9	8
108	3x49	3x50	13.96	Yes	Yes	0	8	9
109	3x49	I2x57	10.83	Yes	No	0	8	7
110	3x50	6x33	8.77	Yes	No	0	9	8
111	3x50	6x34	3.88	Yes	No	0	9	7
112	3x50	6x37	5.23	Yes	No	0	9	8
113	3x51	3x52	3.52	Yes	Yes	6	8	4
114	3x51	3x55	6.72	Yes	Yes	6	8	7
115	3x51	3x56	4.36	Yes	Yes	6	8	6
116	3x51	5x57	15.24	Yes	No	0	8	7
117	3x51	5x61	3.59	Yes	No	0	8	9
118	3x52	3x56	5.14	Yes	Yes	6	4	6
119	3x52	I2x57	4.24	Yes	No	0	4	7
120	3x54	3x55	3.27	No	Yes	0	9	7
121	3x54	5x61	4.37	No	No	0	9	9
122	3x54	6x34	6.08	No	No	0	9	7
123	3x55	3x56	4.42	Yes	Yes	6	7	6
124	I2x52	I2x55	4.5	No	No	0	4	4
125	I2x52	I2x56	7.05	No	No	0	4	4
126	4x39	4x43	3.71	No	No	5	3	3
127	4x40	4x44	3.06	No	No	0	4	4
128	4x41	4x44	3.71	No	No	0	5	4
129	4x42	4x46	3.04	No	No	0	7	7
130	4x45	4x49	5.02	No	Yes	7	6	7
131	4x51	4x55	4.15	No	No	0	3	4
132	4x59	4x60	3.53	No	No	0	5	7
133	4x59	4x62	2.98	No	No	0	5	5
134	4x61	4x64	7.53	No	Yes	0	5	5
135	4x64	4x65	4.52	Yes	No	0	5	6
136	4x64	E2.I228	3.04	Yes	No	0	5	5
137	4x64	5x39	3.17	Yes	No	0	5	6
138	4x65	E2x52	8.39	No	No	0	6	5
139	E2.G208	E2.T227	3.64	No	No	0	4	3
140	E2.E209	E2.L222	13.25	No	No	0	5	4
141	E2.Q210	E2x51	4.25	No	No	0	1	4
142	E2.Q210	E2.T227	7.09	No	No	0	1	3
143	E2.H218	E2.R212	34.98	No	No	0	3	1
144	E2.G220	E2.R212	4.5	No	No	0	5	1
145	E2.V223	E2x51	3.17	No	No	0	4	4
146	E2x51	E2x52	6.99	No	No	0	4	5
147	5x35	E2.I228	7.6	No	No	0	4	5
148	5x36	E2.I228	3.07	No	No	0	5	5
149	5x37	6x59	6.47	No	Yes	0	4	3
150	5x40	6x55	7.52	No	Yes	0	6	6
151	5x40	6x59	3.27	No	Yes	0	6	3
152	5x40	Lig	4.65	No	Yes	0	6	0
153	5x41	6x59	7.63	No	Yes	8	5	3
154	5x41	6x60	9.02	No	No	8	5	5
155	5x43	5x461	7.45	No	Yes	1	6	6
156	5x43	6x55	6.03	No	Yes	1	6	6
157	5x44	6x52	6.85	No	No	0	6	7
158	5x44	6x56	2.95	No	No	0	6	6
159	5x45	5x48	6.28	No	No	0	5	5
160	5x461	6x52	4.18	Yes	No	0	6	7
161	5x47	5x51	8.71	Yes	No	0	8	6
162	5x47	6x44	4.29	Yes	No	0	8	9
163	5x47	6x49	7.31	Yes	No	0	8	7
164	5x47	6x52	15.84	Yes	No	0	8	7
165	5x49	5x50	4.33	No	No	0	6	9
166	5x51	6x45	3.04	No	No	0	6	7
167	5x54	6x41	3.07	No	No	0	8	8
168	5x58	5x61	8.38	Yes	No	0	9	9
169	5x58	6x37	3.79	Yes	No	0	9	8
170	5x58	6x38	11.72	Yes	No	0	9	5
171	5x60	5x64	6.07	No	No	0	5	5
172	5x63	5x64	3.64	No	No	0	4	5
173	5x65	6x31	4.86	No	No	0	8	5
174	5x67	5x68	3.23	No	No	0	4	6
175	5x68	5x71	4.47	No	No	0	6	7
176	5x70	6x27	5.43	No	No	0	4	3
177	5x71	6x27	5.43	No	No	9	7	3
178	5x71	6x31	4.86	No	No	9	7	5
179	5x72	6x26	7.65	No	No	0	5	4
180	5x74	5x76	5.75	No	No	0	5	2
181	5x75	5x76	3.49	No	No	0	4	2
182	6x27	6x31	11.91	No	No	9	3	5
183	6x28	6x29	3.62	No	No	0	5	6
184	6x29	6x32	4.82	No	No	0	6	8
185	6x36	7x56	7.45	No	No	0	8	7
186	6x40	7x49	2.96	No	Yes	0	8	9
187	6x43	7x48	3.25	No	No	0	7	6
188	6x44	6x48	12.03	No	Yes	0	9	8
189	6x47	7x45	3.44	No	No	0	9	9
190	6x48	7x41	4.01	Yes	Yes	0	8	7
191	6x48	7x45	9.88	Yes	No	0	8	9
192	6x49	6x50	3.28	No	No	0	7	9
193	6x50	7x40	3.28	No	No	0	9	7
194	6x51	6x54	3.09	No	Yes	1	6	5
195	6x51	6x55	10.29	No	Yes	1	6	6
196	6x54	6x55	4.26	Yes	Yes	1	5	6
197	6x54	7x34	12.35	Yes	No	1	5	4
198	6x54	7x37	11.64	Yes	No	0	5	6
199	6x54	7x38	6.03	Yes	No	1	5	6
200	6x54	Lig	12.67	Yes	Yes	1	5	0
201	6x57	6x61	4.37	Yes	No	0	4	3
202	6x57	7x33	7.46	Yes	No	0	4	4
203	6x57	Lig	8.29	Yes	Yes	0	4	0
204	6x58	Lig	30.17	No	Yes	0	4	0
205	6x59	6x60	4.03	Yes	No	8	3	5
206	7x27	E3.W334	5.79	No	No	1	2	4
207	7x30	E3.W334	13.5	Yes	No	1	4	4
208	E3.W334	Lig	6.68	No	Yes	1	4	0
209	7x23	7x24	5.25	No	No	0	4	4
210	7x23	7x26	4.42	No	No	0	4	1
211	7x26	7x30	4.69	No	Yes	0	1	4
212	7x27	Lig	3.06	No	Yes	1	2	0
213	7x28	7x32	3.45	No	No	0	1	1
214	7x29	7x30	6.19	No	Yes	0	4	4
215	7x30	Lig	8.41	Yes	Yes	1	4	0
216	7x31	7x32	3.27	No	No	0	4	1
217	7x31	7x35	6.57	No	No	0	4	3
218	7x33	7x37	5.19	No	No	0	4	6
219	7x34	7x38	5.81	No	No	1	4	6
220	7x34	Lig	12.99	No	Yes	1	4	0
221	7x41	7x42	10.32	Yes	Yes	0	7	7
222	7x48	7x52	5.71	No	No	0	6	8
223	7x49	7x50	3.26	Yes	Yes	0	9	9
224	7x49	7x53	9.3	Yes	Yes	0	9	9
225	7x53	8x50	10.32	Yes	Yes	0	9	8
226	7x54	8x50	8.46	No	Yes	2	7	8
227	7x54	8x51	3.62	No	No	0	7	9
228	7x54	8x54	15.71	No	Yes	2	7	7
229	8x47	8x49	7.45	No	No	0	8	7
230	8x50	8x54	11.79	Yes	Yes	2	8	7
231	8x51	8x55	4.86	No	No	0	9	4
232	8x54	8x58	4.87	Yes	No	2	7	7
233	5x32	5x34	2.93	No	No	0	4	1
234	2x39	3x49	2.85	No	Yes	0	8	8
235	3x41	4x49	2.85	No	Yes	0	6	7
236	6x38	6x42	2.85	No	No	0	5	5
237	3x42	4x49	2.83	No	Yes	0	8	7
238	3x21	E1x50	2.81	No	Yes	0	8	8
239	3x55	5x64	2.79	Yes	No	0	7	5
240	2x551	3x31	2.77	No	No	0	5	5
241	3x30	4x57	2.77	Yes	No	0	6	7
242	3x40	6x44	2.77	No	No	0	8	9
243	3x50	3x53	2.77	Yes	No	0	9	8
244	3x52	I2x56	2.77	Yes	No	0	4	4
245	2x62	E1x51	2.67	Yes	No	0	5	3
246	4x38	4x41	2.64	No	No	0	8	5
247	8x47	8x50	2.64	No	Yes	0	8	8
248	4x59	4x63	2.62	No	No	0	5	4
249	E2.R212	E2.V223	2.62	No	No	0	1	4
250	3x47	5x58	2.54	No	Yes	0	9	9
251	1x43	2x57	2.49	No	Yes	0	7	8
252	1x33	2x66	2.45	No	Yes	0	6	5
253	1x43	2x55	2.44	No	No	0	7	5
254	7x25	7x26	2.44	No	No	0	2	1
255	6x36	7x53	2.34	No	Yes	0	8	9
256	5x76	6x28	2.33	No	No	0	2	5
257	7x27	7x28	2.3	No	No	0	2	1
258	2x52	4x50	2.28	No	Yes	0	8	9
259	3x23	3x24	1.95	No	No	0	1	6
260	3x40	5x50	1.87	No	No	0	8	9
261	5x72	5x73	1.86	No	No	0	5	4
262	1x48	1x49	1.84	No	No	0	5	9
263	3x34	4x57	1.79	No	No	0	6	7
264	1x46	2x54	1.71	No	No	0	8	7
265	1x54	2x44	1.71	No	No	0	8	6
266	1x57	2x44	1.71	No	No	0	7	6
267	5x70	5x73	1.71	No	No	0	4	4
268	6x47	7x43	1.71	No	No	0	9	5
269	3x44	5x53	1.7	No	No	0	8	6
270	E2.G221	E2.N211	1.7	No	No	0	2	2
271	I2x53	I2x57	1.61	No	No	0	6	7
272	3x43	6x40	1.6	No	No	0	8	8
273	3x43	6x41	1.6	No	No	0	8	8
274	5x38	5x42	1.6	No	No	0	4	5
275	2x56	3x31	1.58	No	No	0	7	5
276	3x53	6x30	1.58	No	No	0	8	7
277	1x45	7x51	1.54	No	No	0	6	6
278	3x33	4x57	1.54	No	No	0	5	7
279	1x31	1x32	1.53	No	No	0	3	5
280	3x56	I2x50	1.53	Yes	No	0	6	8
281	5x74	6x26	1.53	No	No	0	5	4
282	5x44	5x48	1.52	No	No	0	6	5
283	6x53	6x57	1.52	No	Yes	0	5	4
284	3x24	E1x52	1.51	No	Yes	0	6	7
285	3x27	3x30	1.51	No	Yes	0	5	6
286	5x33	5x37	1.5	No	No	0	4	4
287	5x72	6x30	1.5	No	No	0	5	7
288	3x48	5x57	1.49	No	No	0	7	7
289	7x36	7x40	1.49	No	No	0	6	7
290	1x36	1x40	1.47	No	No	0	6	5
291	5x59	5x60	1.47	No	No	0	3	5
292	5x59	5x63	1.47	No	No	0	3	4
293	8x48	8x52	1.46	No	No	0	4	4
294	5x62	5x66	1.45	No	No	0	6	5
295	7x51	7x55	1.43	No	No	0	6	6
296	7x48	7x49	1.42	No	Yes	0	6	9
297	3x30	4x54	1.39	Yes	No	0	6	4
298	1x54	2x48	1.38	No	No	0	8	6
299	1x59	8x56	1.38	No	No	0	5	4
300	5x32	5x35	1.37	No	No	0	4	4
301	1x39	7x39	1.33	Yes	No	0	7	5
302	1x51	1x55	1.3	No	No	0	4	4
303	1x55	8x57	1.3	No	Yes	0	4	5
304	1x30	1x33	1.26	No	No	0	2	6
305	1x38	1x39	1.26	No	Yes	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg. Int. Strength	Num. Of Links	Community	ConSurf
1	1x39	5.19714	7	1	7
2	1x50	6.8625	4	0	9
3	1x52	5.7225	4	2	6
4	1x56	4.318	5	2	7
5	2x41	6.12	4	5	5
6	2x49	4.262	5	4	8
7	2x57	7.745	4	1	8
8	2x60	5.904	5	1	6
9	2x62	5.8275	4	3	5
10	2x63	8.865	4	3	5
11	2x66	8.5725	4	0	5
12	E1x50	7.996	5	3	8
13	E1x52	6.666	5	3	7
14	3x28	10.27	4	0	6
15	3x30	4.1575	4	0	6
16	3x37	8.5725	4	1	7
17	3x49	7.9675	4	0	8
18	3x50	6.922	5	0	9
19	3x51	6.686	5	6	8
20	3x52	3.9175	4	6	4
21	3x55	4.3	4	6	7
22	3x56	3.8625	4	6	6
23	4x49	3.45	4	7	7
24	4x50	4.015	4	4	9
25	4x64	4.565	4	0	5
26	5x461	4.6625	4	1	6
27	5x47	9.0375	4	0	8
28	5x58	6.6075	4	0	9
29	6x48	7.6925	4	0	8
30	6x54	8.34	6	1	5
31	6x55	7.025	4	1	6
32	6x57	5.41	4	0	4
33	6x59	5.35	4	8	3
34	7x30	8.1975	4	1	4
35	7x41	8.83	4	0	7
36	7x42	11.53	4	1	7
37	7x49	4.212	5	0	9
38	7x50	4.335	4	0	9
39	7x53	9.3	4	0	9
40	8x50	7.42	5	2	8
41	8x54	9.61	5	2	7
42	8x57	3.9125	4	2	5
43	Lig	10.865	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	2x60	2x65	10.8266	4.1	Yes	No	0	6	4
2	2x60	7x42	30.5825	10.1	Yes	Yes	1	6	7
3	2x60	3x32	41.0255	4.65	Yes	No	0	6	7
4	3x32	7x41	58.3886	17.1	No	Yes	0	7	7
5	6x48	7x41	24.1018	4.01	Yes	Yes	0	8	7
6	7x41	7x42	35.8656	10.32	Yes	Yes	0	7	7
7	2x53	7x41	100	3.89	No	Yes	0	7	7
8	2x53	7x46	49.3454	4.8	No	No	0	7	9
9	2x50	7x46	47.5805	7.36	No	No	0	9	9
10	1x50	2x50	47.0503	12.12	Yes	No	0	9	9
11	1x50	7x50	38.8792	6.52	Yes	Yes	0	9	9
12	7x49	7x50	37.0817	3.26	Yes	Yes	0	9	9
13	7x49	7x53	15.0471	9.3	Yes	Yes	0	9	9
14	7x53	8x50	11.6149	10.32	Yes	Yes	0	9	8
15	2x53	3x35	52.9683	3.38	No	No	0	7	7
16	2x49	3x35	51.6196	3.44	Yes	No	0	8	7
17	2x49	4x50	49.7756	3.71	Yes	Yes	4	8	9
18	2x45	4x50	49.478	6.18	No	Yes	0	9	9
19	2x45	3x42	46.8248	8.94	No	No	0	9	8
20	3x42	4x49	48.2293	2.83	No	Yes	0	8	7
21	3x45	4x49	46.2016	3.1	No	Yes	7	7	7
22	2x42	3x45	45.7435	6.97	No	No	0	8	7
23	2x42	3x46	45.1203	12.86	No	No	0	8	9
24	3x46	6x37	44.4762	2.98	No	No	0	9	8
25	3x50	6x37	30.7987	5.23	Yes	No	0	9	8
26	3x28	3x32	41.3068	13.38	Yes	No	0	6	7
27	2x59	3x28	13.6356	7.57	No	Yes	0	6	6
28	2x59	E1x52	12.8659	3.93	No	Yes	0	6	7
29	2x60	7x38	61.6068	3.94	Yes	No	1	6	6
30	3x28	3x29	29.7663	12.91	Yes	No	0	6	4
31	3x29	4x65	15.9423	10.78	No	No	0	4	6
32	4x65	E2x52	10.6034	8.39	No	No	0	6	5
33	3x29	4x61	13.8751	3.59	No	No	0	4	5
34	3x36	6x48	10.5895	4.85	No	Yes	0	7	8
35	3x36	5x461	10.0779	3.2	No	Yes	0	7	6
36	6x54	7x38	35.7424	6.03	Yes	No	1	5	6
37	6x40	7x49	26.8387	2.96	No	Yes	0	8	9
38	3x43	6x40	26.2109	1.6	No	No	0	8	8
39	3x43	6x41	25.5831	1.6	No	No	0	8	8
40	5x54	6x41	24.9552	3.07	No	No	0	8	8
41	3x47	5x54	23.0787	6.19	No	No	0	9	8
42	5x58	6x37	20.5697	3.79	Yes	No	0	9	8
43	5x58	5x61	31.9777	8.38	Yes	No	0	9	9
44	3x51	5x61	21.1045	3.59	Yes	No	0	8	9
45	3x47	5x58	22.4881	2.54	No	Yes	0	9	9
46	3x54	3x55	12.6264	3.27	No	Yes	0	9	7
47	5x40	6x55	10.3314	7.52	No	Yes	0	6	6
48	5x40	6x59	18.0421	3.27	No	Yes	0	6	3
49	6x54	Lig	25.3738	12.67	Yes	Yes	1	5	0
50	5x40	Lig	13.7565	4.65	No	Yes	0	6	0
51	7x34	7x38	24.9436	5.81	No	No	1	4	6
52	7x34	Lig	23.9205	12.99	No	Yes	1	4	0
53	6x44	6x48	11.3289	12.03	No	Yes	0	9	8
54	3x55	5x64	17.3654	2.79	Yes	No	0	7	5
55	3x50	3x53	18.1025	2.77	Yes	No	0	9	8
56	3x53	6x30	17.1306	1.58	No	No	0	8	7
57	5x72	6x30	16.2562	1.5	No	No	0	5	7
58	7x27	Lig	11.508	3.06	No	Yes	1	2	0
59	7x30	Lig	13.824	8.41	Yes	Yes	1	4	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
5x40	6x55	7.52	0	No	Yes	6	6	1	2
5x40	6x59	3.27	0	No	Yes	6	3	1	2
5x40	Lig	4.65	0	No	Yes	6	0	1	0
6x51	6x54	3.09	1	No	Yes	6	5	2	1
6x51	6x55	10.29	1	No	Yes	6	6	2	2
6x54	6x55	4.26	1	Yes	Yes	5	6	1	2
6x54	7x34	12.35	1	Yes	No	5	4	1	1
6x54	7x37	11.64	1	Yes	No	5	6	1	2
6x54	7x38	6.03	1	Yes	No	5	6	1	2
6x54	Lig	12.67	1	Yes	Yes	5	0	1	0
6x57	6x61	4.37	0	Yes	No	4	3	1	2
6x57	7x33	7.46	0	Yes	No	4	4	1	2
6x57	Lig	8.29	0	Yes	Yes	4	0	1	0
6x58	Lig	30.17	0	No	Yes	4	0	1	0
7x27	E3.W334	5.79	1	No	No	2	4	1	1
7x30	E3.W334	13.5	1	Yes	No	4	4	1	1
E3.W334	Lig	6.68	1	No	Yes	4	0	1	0
7x26	7x30	4.69	0	No	Yes	1	4	2	1
7x27	Lig	3.06	1	No	Yes	2	0	1	0
7x29	7x30	6.19	0	No	Yes	4	4	2	1
7x30	Lig	8.41	1	Yes	Yes	4	0	1	0
7x33	7x37	5.19	0	No	No	4	6	2	2
7x34	7x38	5.81	1	No	No	4	6	1	2
7x34	Lig	12.99	1	No	Yes	4	0	1	0
7x27	7x28	2.3	1	No	No	2	1	1	2
6x53	6x57	1.52	0	No	Yes	5	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	7UL2	SR48692	7UL2-NTS₁-SR48692-Na
54.55	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
53.85	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
50.00	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
50.00	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
46.67	Consensus	nts1_off	Orthosteric Ligand	6Z4Q-NTS₁-SR142948A 6Z4S-NTS₁-SR48692
46.67	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
46.67	Consensus	nts_off	Orthosteric Ligand	nts1_off
46.67	Consensus	nts_on	Orthosteric Ligand	nts1_on
43.75	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
43.75	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
42.86	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
40.00	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
40.00	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
40.00	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
40.00	Consensus	nts1_on_allo	Orthosteric Ligand	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
38.89	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
38.46	Single	6ZIN	SR48692	6ZIN-NTS₁-SR48692
37.50	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
35.71	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
35.29	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
35.29	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
33.33	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
33.33	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
33.33	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
31.25	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
31.25	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
31.25	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
31.25	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
30.77	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
30.77	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
30.77	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
29.41	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
29.41	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
29.41	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
29.41	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
29.41	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
28.57	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
28.57	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
28.57	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
28.00	Single	8FEG	PRD_002517	8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
26.67	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
26.67	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
26.67	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
26.67	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
26.67	Consensus	cck_off	Orthosteric Ligand	ccka_off
26.67	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
26.32	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
25.00	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
25.00	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
25.00	Single	5N2S	PSB36	5N2S-A₁-PSB36
25.00	Single	7V6A	PubChem 9864275	7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
25.00	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.00	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
25.00	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
25.00	Single	8QOT	Nanobody E	8QOT-μ-Nanobody E
25.00	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
24.14	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
24.14	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
24.14	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
23.81	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
23.53	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
23.53	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53	Consensus	npy_off	Orthosteric Ligand	npy2_off npy1_off
23.08	Single	4MQT	LY2119620	4MQT-M₂-Iperoxo-LY2119620
23.08	Single	6U1N	LY2119620	6U1N-M₂-LY2119620-Arrestin2
23.08	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
23.08	Single	7VGX	Neuropeptide Y	7VGX-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
22.73	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
22.73	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
22.22	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
22.22	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2
22.22	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
21.74	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
21.74	Consensus	nmur2_on	Orthosteric Ligand	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74	Consensus	nmur_on	Orthosteric Ligand	nmur1_on nmur2_on
21.43	Single	5K2D	ZM241385	5K2D-A_2A-ZM241385
21.43	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
21.43	Single	6JZH	ZM241385	6JZH-A_2A-ZM241385-Na
21.43	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
21.43	Single	6PS7	ZM241385	6PS7-A_2A-ZM241385-Na
21.43	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
21.43	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
21.43	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
21.43	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
21.43	Consensus	class-f_off	Orthosteric Ligand	smo_off
21.43	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
21.43	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
21.43	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
21.05	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2
21.05	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
21.05	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.05	Consensus	cckb_on	Orthosteric Ligand	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
21.05	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
21.05	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.83	Consensus	gs_neuromedin	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00	Single	5IU4	ZM241385	5IU4-A_2A-ZM241385-Na
20.00	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
20.00	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
20.00	Single	5JTB	ZM241385	5JTB-A_2A-ZM241385
20.00	Single	5K2C	ZM241385	5K2C-A_2A-ZM241385-Na
20.00	Single	5NLX	ZM241385	5NLX-A_2A-ZM241385-Na
20.00	Single	5NM4	ZM241385	5NM4-A_2A-ZM241385-Na
20.00	Single	5UVI	ZM241385	5UVI-A_2A-ZM241385
20.00	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
20.00	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
20.00	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
20.00	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
20.00	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
20.00	Single	8HQN	9(S)-HODE	8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
20.00	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00	Single	8SAI	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine	8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
20.00	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
20.00	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
20.00	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
20.00	Consensus	gi_neuromedin	Orthosteric Ligand	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
20.00	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
20.00	Consensus	go_galanin	Orthosteric Ligand	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
20.00	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
20.00	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
20.00	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
20.00	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
19.23	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
19.23	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
19.05	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
19.05	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
19.05	Consensus	nmur1_on	Orthosteric Ligand	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
18.75	Single	3EML	ZM241385	3EML-A_2A-ZM241385
18.75	Single	4EIY	ZM241385	4EIY-A_2A-ZM241385-Na
18.75	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
18.75	Single	5K2A	ZM241385	5K2A-A_2A-ZM241385-Na
18.75	Single	5OLG	ZM241385	5OLG-A_2A-ZM241385-Na
18.75	Single	5UEN	DU172	5UEN-A₁-DU172
18.75	Single	5VRA	ZM241385	5VRA-A_2A-ZM241385-Na
18.75	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
18.75	Single	6LPJ	ZM241385	6LPJ-A_2A-ZM241385-Na
18.75	Single	6LPK	ZM241385	6LPK-A_2A-ZM241385-Na
18.75	Single	6S0L	ZM241385	6S0L-A_2A-ZM241385
18.75	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
18.75	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
18.75	Consensus	a2_off	Orthosteric Ligand	a2a_off
18.75	Consensus	a2a_off	Orthosteric Ligand	8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 5UIG-A_2A-J3.651.884G 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-PubChem 168451710 5K2D-A_2A-ZM241385
18.75	Consensus	ffa_on	Orthosteric Ligand	ffa4_on ffa1_on ffa2_on ffa3_on
18.75	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
18.75	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
18.75	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
18.75	Consensus	p2y12_off	Orthosteric Ligand	4NTJ-P2Y₁₂-AZD1283 7PP1-P2Y₁₂-Selatogrel
18.75	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
18.52	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
18.18	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
18.18	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
18.18	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
18.18	Single	7V68	PubChem 57664406	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
18.18	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
18.18	Consensus	cx3cr_on	Orthosteric Ligand	cx3cr1_on
18.18	Consensus	sst_off	Orthosteric Ligand	sst2_off
17.65	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
17.65	Single	5N2R	PubChem 92460631; psb36	5N2R-A_2A-PubChem 92460631; psb36-Na
17.65	Single	5NM2	ZM241385	5NM2-A_2A-ZM241385-Na
17.65	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
17.65	Single	6LPL	ZM241385	6LPL-A_2A-ZM241385-Na
17.65	Single	6S0Q	ZM241385	6S0Q-A_2A-ZM241385
17.65	Single	6WQA	ZM241385	6WQA-A_2A-ZM241385-Na
17.65	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
17.65	Single	7RM5	ZM241385	7RM5-A_2A-ZM241385-Na
17.65	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
17.65	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
17.65	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
17.65	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
17.65	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65	Single	7Y27	Somatostatin-14	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65	Single	8FYN	ZM241385	8FYN-A_2A-ZM241385-Na
17.65	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
17.65	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
17.65	Consensus	gs_sst	Orthosteric Ligand	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
17.39	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1
17.39	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
17.39	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
17.39	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
17.39	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;2
17.39	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
17.39	Consensus	cx3cr1_on	Orthosteric Ligand	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
17.39	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
17.39	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
17.39	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
17.39	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
17.39	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
16.67	Single	3RFM	Caffeine	3RFM-A_2A-Caffeine
16.67	Single	6OS1	TRV026	6OS1-AT₁-TRV026
16.67	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
16.67	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
16.67	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
16.67	Single	7XOX	Cholecystokinin-8	7XOX-CCK_B-Cholecystokinin-8-Gq/&β;1/&γ;2
16.67	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2
16.67	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
16.67	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
16.67	Single	8X16	Piclidenoson	8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
16.67	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
16.67	Consensus	5ht1b_on	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
16.67	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
16.67	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
16.67	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
16.67	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
16.67	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
16.67	Consensus	cml1_on	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
16.67	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
16.67	Consensus	ffa4_on	Orthosteric Ligand	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
16.67	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
16.67	Consensus	gi_ffa	Orthosteric Ligand	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
16.67	Consensus	gs_compl-peptide	Orthosteric Ligand	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
16.00	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
16.00	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
16.00	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
16.00	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.00	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00	Consensus	gs_melanocortin	Orthosteric Ligand	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2
15.79	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
15.79	Single	6OS2	TRV026	6OS2-AT₁-TRV026
15.79	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2
15.79	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
15.79	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/&β;1/&γ;2
15.79	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/&β;1/&γ;2
15.79	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/&β;1/&γ;2
15.79	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
15.79	Consensus	peptide_off	Orthosteric Ligand	opioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
15.79	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
15.38	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
15.38	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
15.38	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
15.38	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
15.38	Single	8EIT	Doconexent	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.38	Single	8J21	Butyric acid	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
15.38	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
15.38	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
15.38	Consensus	ffa3_on	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
15.38	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
15.00	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
15.00	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
15.00	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
15.00	Single	7EZC	UKA	7EZC-A_2A-UKA
15.00	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
15.00	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
15.00	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
15.00	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
15.00	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
15.00	Consensus	c5a1_off_ortoallo	Orthosteric Ligand	6C1Q-C5a₁-PMX53-NDT9513727 6C1R-C5a₁-PMX53-Avacopan; Na
15.00	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00	Consensus	gs_galanin	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00	Consensus	gs_orexin	Orthosteric Ligand	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.00	Consensus	orexin_on	Orthosteric Ligand	ox2_on
14.81	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
14.81	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
14.81	Consensus	etb_on	Orthosteric Ligand	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
14.81	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
14.29	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
14.29	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
14.29	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
14.29	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
14.29	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
14.29	Single	6PT3	DPI-287	6PT3-δ-DPI-287
14.29	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
14.29	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
14.29	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
14.29	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
14.29	Single	7XP6	Strychnine	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
14.29	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
14.29	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
14.29	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
14.29	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
14.29	Single	8INR	Alpha-MSH	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.29	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
14.29	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
14.29	Consensus	class-t_on	Orthosteric Ligand	taste2_on
14.29	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
14.29	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
14.29	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
14.29	Consensus	go_protein	Orthosteric Ligand	go_chemokine
14.29	Consensus	go_vasopressin	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
14.29	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
14.29	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
14.29	Consensus	gs_bombesin	Orthosteric Ligand	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29	Consensus	gs_class-t	Orthosteric Ligand	gs_taste
14.29	Consensus	gs_endothelin	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
14.29	Consensus	gs_taste	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
14.29	Consensus	m4_on_allo	Other Ligand	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
14.29	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
14.29	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.29	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
14.29	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
14.29	Consensus	taste2_on	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.79	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
13.79	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
13.79	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
13.64	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
13.64	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
13.64	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
13.64	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
13.64	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
13.64	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
13.64	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
13.64	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
13.64	Consensus	mop_off	Orthosteric Ligand	7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
13.64	Consensus	sst2_on	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
13.33	Single	3PWH	ZM241385	3PWH-A_2A-ZM241385
13.33	Single	3VG9	ZM241385	3VG9-A_2A-ZM241385-Antibody
13.33	Single	3VGA	ZM241385	3VGA-A_2A-ZM241385-Antibody
13.33	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
13.33	Single	5OLH	Vipadenant	5OLH-A_2A-Vipadenant-Na
13.33	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
13.33	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
13.33	Single	7T94	PubChem 57664406	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
13.33	Single	7TUZ	7alpha,25-dihydroxycholesterol	7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
13.33	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
13.33	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
13.33	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
13.33	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
13.33	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
13.33	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
13.33	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
13.33	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33	Consensus	a2a_off_allo	Orthosteric Ligand	6ZDR-A_2A-HMS1413f12-Na 6GT3-A_2A-Imaradenant-Na 8CU7-A_2A-LJ-4517-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PubChem 92460631; psb36-Na 5MZJ-A_2A-Theophylline-Na 5OLO-A_2A-Tozadenant-Na 5OLH-A_2A-Vipadenant-Na 5NM4-A_2A-ZM241385-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5MZP-A_2A-Caffeine-Na 8CIC-A_2A-Etrumadenant-Na
13.33	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
13.33	Consensus	ffa3_on_allo	Orthosteric Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
13.33	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
13.33	Consensus	m2_on_allo	Other Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
13.33	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
13.04	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
13.04	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
13.04	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
13.04	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/&β;1/&γ;2
13.04	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
13.04	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
13.04	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
13.04	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
13.04	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
13.04	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
13.04	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
13.04	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
13.04	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.04	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
13.04	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
13.04	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
12.90	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
12.50	Single	3REY	PubChem 5697	3REY-A_2A-PubChem 5697
12.50	Single	3UZC	PubChem 135566609	3UZC-A_2A-PubChem 135566609
12.50	Single	4DKL	Beta-funaltrexamine	4DKL-μ-Beta-funaltrexamine
12.50	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
12.50	Single	5K2B	ZM241385	5K2B-A_2A-ZM241385-Na
12.50	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
12.50	Single	6AQF	ZM241385	6AQF-A_2A-ZM241385
12.50	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
12.50	Single	6MH8	ZM241385	6MH8-A_2A-ZM241385
12.50	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
12.50	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
12.50	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
12.50	Single	7BB6	Acyclovir triphosphate	7BB6-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
12.50	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
12.50	Single	7F4D	Alpha-MSH	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
12.50	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
12.50	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.50	Single	7S8P	MS47134	7S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50	Single	7T32	ZM241385	7T32-A_2A-ZM241385
12.50	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
12.50	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
12.50	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
12.50	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
12.50	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
12.50	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/&β;1/&γ;2
12.50	Single	8T3V	DHA	8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
12.50	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
12.50	Consensus	dop_off_allo	Orthosteric Ligand	4N6H-δ-Naltrindole-Na
12.50	Consensus	ffa2_on	Orthosteric Ligand	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
12.50	Consensus	gi_chemerin	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
12.50	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
12.50	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
12.50	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
12.50	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.50	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.00	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
12.00	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
12.00	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
12.00	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
12.00	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
12.00	Consensus	gi_somatostatin	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
11.76	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
11.76	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
11.76	Single	5UIG	J3.651.884G	5UIG-A_2A-J3.651.884G
11.76	Single	5ZKP	Foropafant (SR27417)	5ZKP-PAF-Foropafant (SR27417)
11.76	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
11.76	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
11.76	Single	7CFM	P395	7CFM-GPBA-P395-Gs/&β;1/&γ;2
11.76	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
11.76	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
11.76	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
11.76	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
11.76	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
11.76	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
11.76	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
11.76	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
11.76	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
11.76	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
11.76	Single	8X17	Namodenoson	8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
11.76	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on
11.76	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
11.76	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
11.76	Consensus	ffa1_on	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on
11.54	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
11.54	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
11.54	Single	7KH0	Acyclovir triphosphate	7KH0-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
11.54	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
11.54	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
11.54	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
11.54	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
11.54	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
11.54	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
11.54	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
11.54	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
11.54	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
11.11	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
11.11	Single	4PHU	Fasiglifam	4PHU-FFA1 (GPR40)-Fasiglifam
11.11	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
11.11	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/&β;1/&γ;2
11.11	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
11.11	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
11.11	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
11.11	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
11.11	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
11.11	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
11.11	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2
11.11	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
11.11	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
11.11	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
11.11	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
11.11	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
11.11	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
11.11	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
11.11	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
11.11	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
11.11	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
11.11	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
11.11	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
11.11	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
11.11	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
11.11	Consensus	a1_on_allo	Orthosteric Ligand	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
11.11	Consensus	a2a_on	Orthosteric Ligand	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
11.11	Consensus	bb1_on	Orthosteric Ligand	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
11.11	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.71	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
10.71	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
10.71	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
10.71	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.71	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
10.71	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
10.53	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
10.53	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
10.53	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
10.53	Single	5TZR	-	5TZR-FFA1 (GPR40)-MK8666
10.53	Single	5V56	TC114	5V56-SMO-TC114
10.53	Single	5V57	TC114	5V57-SMO-TC114
10.53	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
10.53	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
10.53	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
10.53	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
10.53	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/&β;1/&γ;2
10.53	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
10.53	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2
10.53	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
10.53	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
10.53	Consensus	a2_on	Orthosteric Ligand	a2a_on a2b_on
10.53	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
10.53	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
10.53	Consensus	cyslt1_off_ortoallo	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
10.53	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A_2A-NECA-Gs/&β;1/&γ;1 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
10.53	Consensus	gs_ffa	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2 8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
10.53	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
10.53	Consensus	mglu2_on	Other Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
10.53	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
10.34	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
10.34	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.34	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
10.34	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
10.34	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
10.34	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
10.34	Consensus	crf1_on	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
10.00	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
10.00	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
10.00	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
10.00	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
10.00	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
10.00	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
10.00	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
10.00	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
10.00	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2
10.00	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2
10.00	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
10.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
10.00	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
10.00	Single	8WU1	KCA	8WU1-CB₁-KCA-Arrestin1
10.00	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
10.00	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
10.00	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
10.00	Consensus	go_5ht	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
10.00	Consensus	gs_bileacid	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
10.00	Consensus	gs_steroid	Orthosteric Ligand	gs_bileacid
10.00	Consensus	gs_trh	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
10.00	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.68	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
9.68	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
9.68	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
9.52	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
9.52	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
9.52	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
9.52	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
9.52	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/&β;1/&γ;2
9.52	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
9.52	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
9.52	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
9.52	Single	8ID8	TUG-891	8ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
9.52	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
9.52	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52	Single	8WRZ	8D0	8WRZ-CB₁-8D0-Arrestin1
9.52	Consensus	bileacid_on	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
9.52	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
9.52	Consensus	ffa4_on_allo	Orthosteric Ligand	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
9.52	Consensus	ot_on	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
9.52	Consensus	steroid_on	Orthosteric Ligand	bileacid_on
9.38	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
9.38	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
9.38	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
9.09	Single	3NY9	PubChem 913103	3NY9-β₂-PubChem 913103
9.09	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
9.09	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
9.09	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
9.09	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
9.09	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
9.09	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
9.09	Single	7XY6	PubChem 11717831	7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
9.09	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
9.09	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/&β;1/&γ;2
9.09	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2 8I95-C3a_B-EP54-Go/&β;1/&γ;2
9.09	Consensus	class-d_off	Orthosteric Ligand	ste2_off
9.09	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
9.09	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
9.09	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
9.09	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
9.09	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
9.09	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
9.09	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.82	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
8.82	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
8.70	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
8.70	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
8.70	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
8.70	Single	7QA8	Peptide	7QA8-STE2-Peptide
8.70	Single	7QA8	Peptide	7QA8-STE2-Peptide
8.70	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
8.70	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
8.70	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
8.70	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
8.70	Single	8G59	TUG-891	8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
8.70	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
8.70	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
8.70	Consensus	class-d_off	Orthosteric Ligand	ste2_off
8.70	Consensus	fpr-alx_on	Orthosteric Ligand	fpr1-alx_on fpr2-alx_on
8.70	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
8.70	Consensus	sst_on	Orthosteric Ligand	sst2_on sst4_on
8.33	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
8.33	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
8.33	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
8.33	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
8.33	Single	8HQM	NPGLY	8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
8.33	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
8.33	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off alpha1b_off
8.33	Consensus	class-c_on	Other Ligand	gabab_on mglu_on
8.33	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
8.33	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
8.11	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
8.00	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
8.00	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
8.00	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
8.00	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
8.00	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
8.00	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
8.00	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
8.00	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
8.00	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
8.00	Consensus	gi_formylpeptide	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
7.69	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
7.69	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
7.69	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
7.69	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
7.69	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
7.69	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
7.69	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
7.69	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
7.69	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
7.69	Consensus	class-d_on	Orthosteric Ligand	ste2_on
7.69	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
7.69	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
7.69	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
7.69	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
7.69	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
7.69	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
7.69	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
7.41	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
7.41	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
7.41	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
7.41	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
7.41	Consensus	bk1_on	Orthosteric Ligand	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41	Consensus	bombesin_on	Orthosteric Ligand	bb2_on bb1_on
7.41	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
7.41	Consensus	gs_bradykinin	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Single	3UZA	GTPL9236	3UZA-A_2A-GTPL9236
7.14	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
7.14	Single	6FJ3	PTH	6FJ3-PTH1-PTH
7.14	Single	6OIK	LY2119620	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
7.14	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/&β;1/&γ;2
7.14	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
7.14	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
7.14	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
7.14	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
7.14	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
7.14	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
7.14	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	7S8O	(R)-Zinc-3573	7S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
7.14	Single	8IU2	Retinal	8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
7.14	Single	8JGB	Conorfamide-Tx2	8JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
7.14	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
7.14	Consensus	adgrg3_on	Orthosteric Ligand	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
7.14	Consensus	class-d_on	Orthosteric Ligand	ste2_on
7.14	Consensus	ghrh_on	Orthosteric Ligand	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
7.14	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
7.14	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
6.90	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
6.90	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.90	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
6.90	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
6.90	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
6.90	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
6.90	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
6.90	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.90	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.67	Single	5OLV	LUAA41063	5OLV-A_2A-LUAA41063-Na
6.67	Single	6HLL	CP99994	6HLL-NK₁-CP99994
6.67	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
6.67	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
6.67	Single	6QNO	All-trans-retinal	6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
6.67	Single	6TQ4	PubChem 16046844	6TQ4-OX₁-PubChem 16046844-Na
6.67	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
6.67	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
6.67	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
6.67	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
6.67	Single	7S8N	(R)-Zinc-3573	7S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
6.67	Single	8A2P	LUAA47070	8A2P-A_2A-LUAA47070-Na
6.67	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/&β;1/&γ;2
6.67	Single	8GGC	Epinephrine	8GGC-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.67	Single	8GGE	Epinephrine	8GGE-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.67	Single	8GH1	Epinephrine	8GH1-β₂-Epinephrine
6.67	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
6.67	Consensus	go_adhesion	Orthosteric Ligand	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
6.67	Consensus	go_class-b2	Orthosteric Ligand	go_adhesion
6.67	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.45	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
6.45	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
6.45	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
6.45	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
6.45	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
6.45	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
6.45	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
6.25	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
6.25	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/&β;1/&γ;2
6.25	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
6.25	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
6.25	Single	6TQ6	PubChem 145714283	6TQ6-OX₁-PubChem 145714283
6.25	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
6.25	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
6.25	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
6.25	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
6.25	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
6.25	Single	7T6S	PubChem 24776341	7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
6.25	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
6.25	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
6.25	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
6.25	Single	8GGF	Epinephrine	8GGF-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.25	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
6.25	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2
6.25	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
6.25	Single	8UO1	Epinephrine	8UO1-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
6.25	Single	8UO3	Epinephrine	8UO3-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
6.25	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
6.25	Consensus	mglu_on	Other Ligand	mglu2_on mglu4_on
6.06	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
6.06	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
6.06	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
6.06	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
5.88	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
5.88	Single	6TPK	Retosiban	6TPK-OT-Retosiban
5.88	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
5.88	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
5.88	Single	6ZDV	PubChem 984073	6ZDV-A_2A-PubChem 984073-Na
5.88	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
5.88	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.88	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
5.88	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/&β;1/&γ;2
5.88	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
5.88	Single	8DWG	ML382	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88	Single	8GDZ	Epinephrine	8GDZ-β₂-Epinephrine-Gs/&β;1/&γ;2
5.88	Single	8GG8	Epinephrine	8GG8-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.88	Single	8GGT	Epinephrine	8GGT-β₂-Epinephrine
5.88	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2
5.88	Single	8GUR	PubChem 104895	8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2
5.88	Single	8JD6	N-(3-chlorophenyl)pyridine-2-carboxamide	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.88	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
5.88	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
5.88	Single	8UO2	Epinephrine	8UO2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.88	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
5.88	Consensus	m1_off_allo	Other Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
5.88	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
5.88	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
5.88	Consensus	vasopressin-ot_off	Orthosteric Ligand	ot_off
5.71	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
5.71	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
5.56	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
5.56	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
5.56	Single	6D27	CAY10471	6D27-DP₂-CAY10471
5.56	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
5.56	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2
5.56	Single	6PS1	Timolol	6PS1-β₂-Timolol
5.56	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.56	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/&β;1/&γ;2
5.56	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.56	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
5.56	Single	7LJC	PubChem 86764103	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
5.56	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
5.56	Single	7V3Z	PubMed 104895	7V3Z-CB₁-PubMed 104895
5.56	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
5.56	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
5.56	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
5.56	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
5.56	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
5.56	Single	8EJC	TAK-875	8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8EJK	TAK-875	8EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.56	Single	8GEB	Epinephrine	8GEB-β₂-Epinephrine-Gs/&β;1/&γ;2
5.56	Single	8GEH	Epinephrine	8GEH-β₂-Epinephrine-Gs/&β;1/&γ;2
5.56	Single	8GGB	Epinephrine	8GGB-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
5.56	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
5.56	Single	8UNM	Epinephrine	8UNM-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
5.56	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
5.56	Consensus	cb1_on_allo	Orthosteric Ligand	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.56	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
5.56	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
5.56	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
5.41	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
5.41	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
5.26	Single	5C1M	BU72	5C1M-μ-BU72
5.26	Single	5X7D	(S)-Carazolol	5X7D-β₂-(S)-Carazolol-PubChem 129318963
5.26	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
5.26	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
5.26	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
5.26	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
5.26	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
5.26	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
5.26	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/&β;1/&γ;2
5.26	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/&β;1/&γ;2
5.26	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
5.26	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
5.26	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
5.26	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
5.26	Single	7XKA	Epinephrine	7XKA-β₂-Epinephrine
5.26	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
5.26	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
5.26	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/&β;1/&γ;2
5.26	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
5.26	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.26	Single	8UNY	Epinephrine	8UNY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.26	Consensus	cb2_on	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
5.26	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
5.26	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.26	Consensus	go_opioid	Orthosteric Ligand	8DZQ-κ-momSalB-Go/&β;1/&γ;2
5.26	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
5.13	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
5.13	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
5.13	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.00	Single	3P0G	BI167107	3P0G-β₂-BI167107
5.00	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/&β;1/&γ;2
5.00	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
5.00	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
5.00	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
5.00	Single	5XR8	AM841	5XR8-CB₁-AM841
5.00	Single	5XRA	AM11542	5XRA-CB₁-AM11542
5.00	Single	6E59	L-760735	6E59-NK₁-L-760735
5.00	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
5.00	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
5.00	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/&β;1/&γ;2
5.00	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
5.00	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
5.00	Single	7FEE	PubMed 104895	7FEE-CB₁-PubMed 104895-ZCZ011
5.00	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/&β;1/&γ;2
5.00	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/&β;1/&γ;2
5.00	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
5.00	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
5.00	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
5.00	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
5.00	Single	7WV9	PubMed 104895	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.00	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/&β;1/&γ;2
5.00	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/&β;1/&γ;2
5.00	Single	8E0G	BU72	8E0G-μ-BU72
5.00	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2
5.00	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
5.00	Single	8JD0	J9R	8JD0-mGlu2; mGlu3-Glutamate-J9R
5.00	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
5.00	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/&β;1/&γ;2
5.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
5.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.00	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
5.00	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
5.00	Consensus	5ht5_off	Orthosteric Ligand	5ht5a_off
5.00	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
5.00	Consensus	gi_dopamine	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
5.00	Consensus	gi_muscarinic	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
5.00	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
5.00	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
5.00	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
5.00	Consensus	nk1_off	Orthosteric Ligand	6J20-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
5.00	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
5.00	Consensus	sst4_on	Orthosteric Ligand	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
4.88	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
4.76	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
4.76	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
4.76	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
4.76	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
4.76	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
4.76	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
4.76	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
4.76	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
4.76	Single	6KQI	PubMed 104895	6KQI-CB₁-PubMed 104895-ORG27569
4.76	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
4.76	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
4.76	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.76	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.76	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
4.76	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
4.76	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
4.76	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/&β;1/&γ;2
4.76	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
4.76	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
4.76	Single	8I95	EP54	8I95-C3a_B-EP54-Go/&β;1/&γ;2
4.76	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2
4.76	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
4.76	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
4.76	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
4.76	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
4.76	Single	8JWY	PubChem 168451710	8JWY-A_2A-PubChem 168451710
4.76	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
4.76	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/&β;1/&γ;2
4.76	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
4.76	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg3_on
4.76	Consensus	cannabinoid_on	Orthosteric Ligand	cb1_on cb2_on
4.76	Consensus	cb1_off_allo	Orthosteric Ligand	6KQI-CB₁-PubMed 104895-ORG27569
4.76	Consensus	cb1_on	Orthosteric Ligand	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
4.76	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on
4.76	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
4.76	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
4.76	Consensus	dp_off	Orthosteric Ligand	dp2_off
4.76	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
4.76	Consensus	gpr119_on	Orthosteric Ligand	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
4.76	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
4.76	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
4.76	Consensus	opioid_off	Orthosteric Ligand	kop_off mop_off nop_off dop_off
4.55	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
4.55	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
4.55	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
4.55	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
4.55	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
4.55	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
4.55	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
4.55	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/&β;1/&γ;2
4.55	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/&β;1/&γ;2
4.55	Single	8E9Y	PubChem 446603	8E9Y-M₃-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55	Single	8GAG	YVF	8GAG-CB₁-YVF-Gi1/&β;1/&γ;2
4.55	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2
4.55	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
4.55	Consensus	5ht5a_off	Orthosteric Ligand	7UM4-5-HT_5A-AS2674723
4.55	Consensus	cyslt2_off	Orthosteric Ligand	6RZ6-CysLT₂-ONO-2570366 6RZ9-CysLT₂-ONO-2770372 6RZ8-CysLT₂-ONO-2080365
4.55	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off
4.55	Consensus	gs_lipid	Orthosteric Ligand	gs_ffa gs_prostanoid
4.35	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.35	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
4.35	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
4.35	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
4.35	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/&β;1/&γ;2
4.35	Consensus	gs_adgr	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Consensus	gs_class-b2	Orthosteric Ligand	gs_adgr
4.35	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
4.35	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
4.35	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
4.35	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
4.17	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
4.17	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
4.17	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
4.17	Single	8GHV	PubChem 145964903	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
4.17	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
4.17	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/&β;1/&γ;2
4.17	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
4.17	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
4.17	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
4.00	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
4.00	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
4.00	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
4.00	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
3.70	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
3.70	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.70	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
3.70	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
3.70	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
3.70	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
3.70	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2
3.70	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/&β;1/&γ;2
3.70	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
3.57	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
3.57	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
3.57	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.45	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
3.45	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
3.45	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
3.45	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
3.33	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
3.33	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
3.33	Consensus	go_class-b1	Orthosteric Ligand	go_crf
3.33	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.33	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
3.23	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
3.23	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
3.23	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
3.23	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
3.23	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
3.23	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
3.23	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
3.12	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
3.12	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
3.12	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.12	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
3.12	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.12	Consensus	gs_crf	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
2.94	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
2.86	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1

Consensus Members
	Id	Members
	7UL2	7UL2-NTS₁-SR48692-Na

Net Summary
I_min	2.95
Number of Linked Nodes	268
Number of Links	305
Number of Hubs	43
Number of Links mediated by Hubs	156
Number of Communities	9
Number of Nodes involved in Communities	52
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	60
Number Of Links MetaPath	59
Number of Shortest Paths	70225
Length Of Smallest Path	3
Average Path Length	15.8937
Length of Longest Path	32
Minimum Path Strength	1.295
Average Path Strength	6.13045
Maximum Path Strength	21.58
Minimum Path Correlation	0.7
Average Path Correlation	0.932651
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	47.496
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.9274
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
	Id	1^st Network	2^nd Network
	nts1_off_ortoallo	nts1_off_allo	nts1_off

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Download nts1_off_allo.zip

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