Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.29 0.960929402
2G.hns1.01 7.40368544
3G.S1.02 6.08891446
4G.s1h1.04 1.12323609
5H.hahb.04 0.07004507
6H.hahb.06 0.0502333404
7H.HB.05 0.1394403
8H.HB.08 0.119083401
9H.hbhc.04 0.150667603
10H.HC.08 0.0609667403
11H.HD.07 0.0660833404
12H.HD.09 0.1144408
13H.hdhe.01 0.0920833406
14H.HE.04 0.150567409
15H.HE.05 0.0928667407
16H.hehf.04 0.103433409
17G.S2.02 2.37381405
18G.S2.06 3.59919609
19G.S3.03 5.74017648
20G.S3.04 8.48614417
21G.S3.06 8.90491517
22G.S3.07 3.66222409
23G.H2.01 7.29322419
24G.H2.06 6.19135619
25G.h2s4.01 10.2059419
26G.s4h3.05 0.138233409
27G.H3.01 1.06297709
28G.H3.03 4.29624404
29G.H3.09 5.49504799
30G.H3.13 10.0195596
31G.H3.17 9.54381615
32G.S5.05 4.868134129
33G.S5.07 3.29172509
34G.hgh4.01 3.91171606
35G.hgh4.02 5.293034118
36G.hgh4.04 4.174325116
37G.hgh4.05 9.55482506
38G.hgh4.11 4.39852405
39G.hgh4.20 5.23346503
40G.hgh4.21 5.74367404
41G.H4.03 3.9755404
42G.H4.08 7.37214463
43G.H4.10 10.73835117
44G.H4.12 6.99556564
45G.H4.14 7.730194115
46G.H4.15 8.91502408
47G.h4s6.08 3.23585405
48G.h4s6.12 4.61296402
49G.h4s6.20 9.92571464
50G.S6.02 9.26952568
51G.S6.05 9.65772565
52G.s6h5.01 6.028034129
53G.H5.03 5.178185129
54G.H5.05 6.39375445
55G.H5.08 5.97369748
56G.H5.17 8.45059565
57G.H5.19 4.33709508
58G.H5.20 3.7385408
59G.H5.23 6.39576404
60G.H5.25 3.43142408
61b.1x1 1.5057404
62b.1x4 1.55307608
63b.h2x1 4.31617405
64b.h2x5 4.71574405
65b.lhb1x6 3.84754153
66b.b1x3 5.08873407
67b.b1x4 3.79703437
68b.l1x3 9.98992539
69b.l1x6 10.7566519
70b.b2x1 6.33571518
71b.b2x3 4.56537436
72b.b2x5 6.44062637
73b.l3x1 8.47851419
74b.l3x2 7.7706449
75b.b4x2 5.50975408
76b.b4x6 9.52493739
77b.b4x7 8.53527438
78b.l4x3 6.36044436
79b.b5x2 8.09492437
80b.b5x3 6.85906639
81b.b5x5 5.75042405
82b.l5x1 4.249075138
83b.l5x5 9.69296619
84b.b6x1 5.365419
85b.b6x5 4.46768406
86b.b7x1 6.34511404
87b.l7x4 3.8939409
88b.b8x3 3.77394406
89b.b8x4 5.74565136
90b.b9x4 6.76199409
91b.l9x3 7.99232519
92b.l9x6 6.33308818
93b.b10x5 4.79546609
94b.l10x1 4.98582403
95b.b11x4 5.84286419
96b.l11x2 8.6104419
97b.b12x6 9.14326618
98b.b13x7 8.03319577
99b.l13x3 7.75043679
100b.l13x6 6.39607519
101b.b15x1 8.63218479
102b.l15x1 6.11261417
103b.b16x4 10.2729476
104b.b16x6 8.29361778
105b.b17x5 7.22027457
106b.b17x7 8.95519458
107b.l17x3 9.35312659
108b.l17x6 8.63624419
109b.b18x3 5.1295458
110b.l18x1 6.474797106
111b.l18x3 8.183994105
112b.b19x2 8.01701556
113b.b19x4 6.37482458
114b.l19x1 5.9377419
115b.l19x2 7.17099559
116b.b20x4 9.99928558
117b.b20x6 6.58508656
118b.b21x1 6.97691657
119b.b21x5 5.62286404
120b.b21x7 6.01854605
121b.l22x5 7.121415159
122b.b23x2 4.88523406
123b.b23x6 8.381076147
124b.b24x5 3.2221405
125b.b24x6 6.911134148
126b.l24x3 4.35684405
127b.b25x7 7.72793407
128b.l25x3 10.1762489
129b.l25x4 5.14599505
130b.l25x6 12.7681518
131b.l28x1 12.0635719
132b.l28x2 9.02394489
133b.b28x2 6.85192404
134b.b28x3 4.63511637
135b.b28x4 8.19419486
136b.b28x6 9.81421589
137g.h1x8 2.42763407
138g.l1x4 4.96051458
139g.h2x11 9.876674106
140g.ctx3 6.43841509
141g.ctx6 3.99471406
142g.ctx14 5.36175439
143g.ctx15 7.30743439
144g.ctx16 5.07611838
145NT 64.5761824
1461x43 4.23634527
1471x60 3.792407
1482x38 2.59272507
1492x39 4.92821409
1502x51 1.92762407
151E1 5.63985623
1523x26 4.71662428
1533x34 3.463255179
1543x35 4.29218405
1553x39 4.40315509
1563x42 8.15991409
1573x46 4.53177609
1583x51 5.02152408
159I2 6.384051647
1604x42 5.93642445
1614x50 7.186494179
162E2 7.072751725
163E2x51 6.28277528
1645x40 3.007424
1655x47 5.4514427
1665x58 4.74874409
1676x47 3.43648508
1686x48 6.18934628
169E3 2.62102924
1707x45 5.20462409
1717x52 4.53664408
1727x54 3.98992409
1738x58 1.30725405
174Lig 9.968253120
175I3 4.10632965
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b4x7 b.l4x3 12.36887.99587YesYes386
2b.b5x2 b.l4x3 14.85418.87622YesYes376
3G.HN.40 b.b5x2 29.725310.7428NoYes377
4G.HN.40 b.b5x3 30.04556.08901NoYes379
5b.b4x4 b.b5x3 15.79544.41002NoYes389
6b.b4x4 b.l1x3 15.953713.6785NoYes389
7b.b3x6 b.l1x3 99.883613.1051NoYes099
8b.b3x6 b.l3x2 1008.35509NoYes099
9b.b4x6 b.b5x3 16.046911.1797YesYes399
10b.b4x6 b.l1x3 82.16764.50588YesYes399
11b.l1x4 b.l3x2 19.716810.8116NoYes469
12G.HN.51 b.l1x4 19.79966.79251NoNo446
13G.hns1.01 b.l3x2 81.20883.83771YesYes449
14G.hns1.01 G.hns1.02 56.71014.0696YesNo444
15G.S1.03 G.hns1.01 98.821320.0634NoYes094
16G.S1.03 G.S3.06 98.83894.41543NoYes097
17G.hns1.02 I2 56.49044.93762NoYes447
18G.HN.51 I2 19.67247.054NoYes447
19G.S3.06 b.l5x5 98.893919.8509YesYes179
20G.h2s4.01 b.l5x5 24.030513.476YesYes199
21G.S1.05 G.h2s4.01 23.845219.5922NoYes099
22G.S1.05 G.S1.07 23.70374.45294NoNo098
23G.S2.06 G.S3.03 11.681210.8002YesYes098
24b.l3x1 b.l5x5 75.45898.45495YesYes199
25G.H2.10 b.l3x1 29.37334.7387NoYes189
26G.H2.10 b.b6x1 29.34154.76897NoYes189
27b.b6x1 b.l9x6 61.40547.06029YesYes198
28b.b2x1 b.l3x1 37.603910.9942YesYes189
29b.b2x1 b.b6x1 32.31335.64373YesYes189
30G.H2.04 G.S1.07 23.65924.24797NoNo098
31G.H2.06 b.l9x6 46.73543.59741YesYes198
32G.H2.04 G.H3.08 31.438210.088NoNo098
33G.H2.06 b.l19x1 45.72644.51258YesYes199
34b.b2x1 b.l28x1 11.08846.20437YesYes189
35b.l25x6 b.l28x1 15.619127.7232YesYes189
36G.H3.08 G.S4.04 31.24867.34538NoNo089
37G.H3.09 G.S4.04 31.15893.68346YesNo099
38G.H3.09 G.H4.15 31.95888.93949YesYes098
39G.H3.06 G.H4.15 31.55449.64774NoYes068
40G.H3.06 G.H4.14 28.89454.79428NoYes065
41G.H4.10 G.H4.14 28.31311.1388YesYes1175
42G.H4.10 G.hgh4.08 27.712513.7135YesNo076
43G.H4.13 G.hgh4.08 24.434510.1304NoNo036
44G.H4.12 G.H4.13 24.32444.05628YesNo043
45G.H4.12 G.H4.16 22.20645.26954YesNo644
46G.H4.16 I3 22.10787.2584NoYes645
47G.h4s6.20 I3 21.01799.43104YesYes645
48G.S6.02 G.h4s6.20 20.27310.5396YesYes684
49G.H5.10 G.S6.02 19.862713.5986NoYes078
50G.H5.10 G.S6.04 19.510712.4378NoNo079
51G.S5.05 G.S6.04 18.11643.60483YesNo099
52G.S5.05 G.s6h5.01 16.9947.13734YesYes1299
53G.S5.07 G.s6h5.01 16.44386.291YesYes099
54G.S4.05 G.S5.07 14.64594.59526NoYes079
55G.H5.16 I2 12.46485.3629NoYes467
565x64 G.H5.16 12.24584.02418NoNo096
573x54 5x64 12.02214.47951NoNo089
58b.l17x5 b.l19x1 45.81644.23806NoYes069
59b.l17x5 b.l19x2 45.62062.50598NoYes069
60b.l17x3 b.l19x2 30.65286.1266YesYes599
61b.b19x4 b.l17x3 15.8819.18473YesYes589
62b.b19x4 b.b20x6 13.32627.52714YesYes586
63b.b17x7 b.b20x6 37.394110.8809YesYes586
64b.b17x7 b.b21x1 30.36485.05623YesYes587
65b.1x19 b.b21x1 23.44817.45888NoYes067
66b.1x15 b.1x19 22.80513.52988NoNo076
67b.1x12 b.1x15 20.87511.8316NoNo067
68b.1x12 g.h1x11 17.65522.34396NoNo069
69b.1x11 g.h1x11 14.65015.36462NoNo089
70b.b20x4 b.l17x3 13.953418.0656YesYes589
71b.b20x4 b.b20x6 26.62633.76452YesYes586
72b.b20x2 b.l19x2 14.364110.3815NoYes069
73b.b20x2 b.b20x4 13.94898.40619NoYes068
74b.l27x5 g.ctx15 31.82785.97219NoYes059
75b.l27x5 g.ctx4 62.0536.17193NoNo057
76g.ctx3 g.ctx4 61.39674.33205YesNo097
77g.ctx3 g.ctx6 56.78428.05333YesYes096
78b.l22x5 g.ctx6 55.46055.5147YesYes096
79b.l22x5 b.lhb1x3 25.90365.24043YesNo092
80b.h2x5 b.lhb1x3 25.22483.6433YesNo052
81b.h2x1 b.h2x5 49.07863.4416YesYes055
82b.b21x5 b.h2x1 43.56745.92545YesYes045
83b.l22x5 b.l24x2 25.90368.40594YesNo096
84b.h2x5 b.l24x2 25.22486.57834YesNo056
85b.b22x1 b.l25x6 16.45636.73284NoYes088
86b.b22x1 b.b22x2 16.23793.68952NoNo088
87b.b22x2 b.b26x3 16.01935.85068NoNo086
88b.b26x3 b.b27x3 15.80053.29154NoNo068
89b.b27x3 b.l25x3 12.10676.96823NoYes089
90b.b28x5 g.ctx16 33.11724.87344NoYes358
91b.l25x3 b.l28x2 10.59369.08657YesYes899
92b.b1x6 b.b4x6 33.799720.6441NoYes399
93b.b3x2 b.b4x6 32.06486.68583NoYes359
94b.b2x5 b.b3x2 31.573210.2383YesNo375
95b.b10x1 b.l9x6 13.31243.21732NoYes098
96b.b10x1 b.b11x5 13.09114.03619NoNo096
97b.l27x3 b.l27x5 30.58837.24497NoNo075
98b.l27x1 b.l27x3 30.71397.01484NoNo377
99b.b2x5 b.l27x1 31.038811.3381YesNo377
100b.b3x1 b.b4x7 24.06443.6693NoYes058
101b.b3x1 b.b6x5 22.69473.99468NoYes056
102b.b3x3 b.b6x5 20.63894.83503NoYes086
103b.b3x3 b.b7x2 17.89563.87397NoNo088
104b.b7x2 b.l8x1 17.20936.21827NoNo085
105b.b4x5 b.l8x1 16.52294.74502NoNo075
106b.b4x5 b.b5x5 15.83646.10702NoYes075
107b.b5x5 b.l8x8 13.77576.24313YesNo054
108b.b5x7 b.l8x8 13.08846.82403NoNo074
109b.l11x1 b.l9x6 10.18038.37144NoYes198
110b.b21x5 b.b21x7 36.69358.95721YesYes045
111b.b21x7 b.b23x2 22.22233.31297YesYes056
112b.b22x5 b.b23x2 18.761111.3916NoYes076
113b.b22x5 b.l18x1 13.89877.64003NoYes1076
114b.b21x7 b.b24x6 11.128710.8988YesYes058
115b.1x11 b.1x7 14.00482.6743NoNo088
116b.1x7 g.h1x8 12.71373.21194NoYes087
1174x42 I2 46.30465.70796YesYes457
1182x45 4x42 43.92525.22163NoYes095
1192x45 3x42 43.52779.32573NoYes099
1203x42 4x50 43.346414.2623YesYes099
1213x46 4x50 40.26183.6924YesYes099
1223x46 6x43 39.34285.04674YesNo099
1236x43 7x53 39.16410.3684NoNo098
1247x52 7x53 38.75653.69527YesNo088
1256x47 7x52 34.25325.4281YesYes088
1266x47 6x48 33.23574.66499YesYes088
1276x48 Lig 27.45244.05978YesYes280
128b.1x4 g.h1x8 10.12951.0955YesYes087
129G.H3.01 G.s1h1.05 14.15963.3302YesNo099
130G.S4.05 G.s1h1.05 14.28382.94764NoNo079
131G.H3.01 G.s1h1.04 13.45832.23235YesYes099
132G.s1h1.04 H.HF.03 12.72710.1126YesNo099
133H.HF.03 H.hehf.04 10.29730.0843333NoYes099
134G.HN.36 b.b5x2 12.5199.33584NoYes347
135G.HN.36 b.b4x7 12.20476.61473NoYes348
136b.b1x6 b.b28x5 33.72633.60213NoNo395
137g.ctx15 g.ctx16 30.81624.48262YesYes398
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
NTNT234.5072YesYes4411
LigNT36.5842YesYes0401
E1NT3.776932YesYes3411
1x29Lig4.261262NoYes2010
1x32Lig8.747352NoYes5010
1x35Lig4.081340NoYes6010
1x361x403.624922NoNo5712
1x39Lig7.376890NoYes7010
1x432x576.231062YesNo7711
1x437x424.154942YesNo7912
1x43Lig4.578562YesYes7010
2x533x363.894760NoNo8621
2x57Lig5.815362NoYes7010
2x603x323.703440NoNo6621
E1E110.05752YesYes3311
E1Lig9.718472YesYes3010
3x26E26.488032YesYes8521
3x26E2x519.387482YesYes8821
3x32Lig4.460642NoYes6010
3x363x405.184342NoNo6812
3x36Lig6.601162NoYes6010
3x405x4711.27270NoYes8721
3x406x487.732050NoYes8821
4x604x644.233122NoNo8822
4x64E2x518.036452NoYes8821
4x68E25.948990NoYes6521
E2E2x514.750712YesYes5811
E2E219.15372YesYes5511
E2x52Lig6.695250NoYes5010
E2Lig25.32812YesYes5010
5x41E23.934132NoYes6521
5x415x444.774662NoNo6621
5x47Lig5.607712YesYes7010
6x476x484.664990YesYes8821
6x487x4111.90012YesNo8611
E3E34.157342YesYes4411
E3Lig4.321262YesYes4010
7x34Lig3.839030NoYes5010
7x37Lig6.521852NoYes8010
7x38Lig6.421652NoYes7010
7x41Lig4.603852NoYes6010
2x573x323.83392NoNo7611
5x44Lig5.556012NoYes6010
6x48Lig4.059782YesYes8010
4x64E26.130812NoYes8521
6x487x455.134662YesYes8912
2x67E23.672030NoYes3521
3x33E24.80072NoYes7521
5x37Lig5.63832NoYes5010
3x30E24.66572NoYes5521
6x487x573.64452YesNo8012
4x60E24.4252NoYes8521
E2x51Lig7.7852YesYes8010
5x40Lig9.152YesYes4010
6x55Lig4.1550NoYes7010
1x432x543.583792YesNo7712
1x36Lig3.498932NoYes5010
7x33E33.467562NoYes7421
6x517x373.421080NoNo7821
3x37E23.26752NoYes6521
1x25NT3.179422NoYes0421
5x425x442.935530NoNo7621
5x39E22.805172NoYes3521
5x475x512.750332YesNo7712
1x432x582.633362YesNo7712
1x311x322.591660NoNo4521
3x29E22.56250NoYes5521
7x30E32.542620NoYes5421
6x587x372.41250NoNo0821
1x442x682.2540NoNo6321
1x24NT2.235652NoYes0421
5x476x572.17492YesNo7012
7x29E32.166480NoYes3421
5x35E21.9850NoYes0521
2x65Lig1.94092NoYes4010
1x28Lig1.759690NoYes0010
1x33Lig1.628390NoYes3010
4x65E2x511.45420NoYes3821
7x32E31.38450NoYes4421
4x635x401.195350NoYes4421
2x73E21.1650NoYes0521
1x21NT1.159140NoYes0421
2x68Lig1.138442NoYes3010
6x567x411.13320NoNo0621
7x28E30.93210NoYes2421
4x675x400.8646190NoYes3421
5x385x400.818050NoYes5421
6x597x380.8050NoNo0721
1x261x290.7810380NoNo0221
1x22NT0.6594950NoYes0421
2x652x660.6468672NoNo4312
5x335x370.58250NoNo0521
7x27E30.4599950NoYes4421
2x71E10.2110NoYes0321
3x20E10.01773330NoYes0321

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
61.54Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
55.88Single6LMLGlucagon6LML-Glucagon-Glucagon
55.17Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
55.17Consensusgs_class-b2Orthosteric Ligandgs_adgr
54.55Single6FJ3PTH6FJ3-PTH1-PTH
53.12Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
52.94Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
52.78Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
52.78Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
51.52Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
51.43Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
51.35Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
50.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
50.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
50.00Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
50.00Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
50.00Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
50.00Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
50.00Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
48.78Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
48.72Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
48.72Consensuspth_onOrthosteric Ligandpth1_on pth2_on
48.65Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
48.57Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
48.57Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
48.57Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
48.57Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
48.48Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
47.37Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
47.22Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
47.22Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
47.06Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
46.15Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
45.95Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
45.71Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
45.71Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
45.71Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
45.71Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
45.71Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
44.74Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
44.74Consensusglp_onOrthosteric Ligandglp1_on glp2_on
44.44Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
44.44Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
44.12Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
44.12Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
44.12Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
43.75Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
43.59Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
43.59Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
43.33Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
43.33Consensusclass-b2_onOrthosteric Ligandadgrg_on
43.24Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
43.24Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
43.24Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
42.86Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
42.86Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
42.86Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
42.86Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
42.86Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
42.86Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
42.86Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
42.42Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
41.67Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
41.67Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
41.46Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
41.03Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
40.54Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
40.54Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
40.54Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
40.00Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
40.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
40.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
40.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
39.47Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
39.47Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
39.47Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
39.47Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
39.47Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
39.47Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
38.89Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
38.46Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
38.24Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
37.84Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
37.84Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
37.84Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
37.84Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
37.84Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
37.78Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
37.50Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
37.14Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
36.84Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
36.84Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
36.59Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
36.11Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
35.90Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
35.90Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
35.00Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
34.29Single3QAKUK-4320973QAK-A2A-UK-432097
34.21Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
34.09Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
33.33Single5WF5UK-4320975WF5-A2A-UK-432097
33.33Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
33.33Consensusgo_class-b1Orthosteric Ligandgo_crf
33.33Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
32.61Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
32.56Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
32.50Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
32.50Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
31.71Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
31.71Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
31.71Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
31.58Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
31.43Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
31.25Single7PX4PSB-21137PX4-A2A-PSB-2113
31.25Consensusadenosine_offOrthosteric Liganda1_off a2_off
31.03Consensusmglu_onOther Ligandmglu2_on mglu4_on
30.56Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
30.56Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
29.41Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
29.27Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
29.27Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
29.27Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
29.03Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
29.03Consensusadenosine_onOrthosteric Liganda1_on a2_on
29.03Consensusnucleotide_onOrthosteric Ligandadenosine_on
28.95Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
28.95Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.95Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single3NY9PubChem 9131033NY9-β2-PubChem 913103
28.57Single4UG2CGS216804UG2-A2A-CGS21680
28.57Single5WF6UK-4320975WF6-A2A-UK-432097
28.57Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
28.57Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
28.57Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
28.57Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
28.21Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
28.21Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
28.12Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
28.12Single5N2SPSB365N2S-A1-PSB36
28.12Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
28.12Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
28.12Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
28.12Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
28.12Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
27.78Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
27.78Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
27.78Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.78Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
27.50Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
27.50Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
27.50Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
27.50Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
27.50Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single5V56TC1145V56-SMO-TC114
27.27Single7EPENAM5637EPE-mGlu-NAM563
27.27Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
27.27Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
27.27Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
27.27Consensusa2_onOrthosteric Liganda2a_on a2b_on
27.27Consensuscck_onOrthosteric Ligandccka_on cckb_on
27.03Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
27.03Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
27.03Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
27.03Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
26.83Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
26.83Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
26.83Consensusgi_class-dOrthosteric Ligandgi_ste
26.83Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
26.47Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.47Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
26.47Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
26.47Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
26.47Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
26.32Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
26.32Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
26.32Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
26.32Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
26.19Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
26.19Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
25.81Single2YDOAdenosine2YDO-A2A-Adenosine
25.81Single5IU7Q274563465IU7-A2A-Q27456346-Na
25.81Single5JTBZM2413855JTB-A2A-ZM241385
25.81Single6MH8ZM2413856MH8-A2A-ZM241385
25.81Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
25.81Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
25.81Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
25.81Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
25.71Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
25.71Single7EZCUKA7EZC-A2A-UKA
25.71Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
25.71Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
25.71Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
25.71Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.71Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
25.71Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
25.64Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.64Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.64Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.64Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.64Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
25.64Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.58Single5GLHEndothelin-15GLH-ETB-Endothelin-1
25.58Single6IGKEndothelin-36IGK-ETB-Endothelin-3
25.58Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
25.00Single3EMLZM2413853EML-A2A-ZM241385
25.00Single4EIYZM2413854EIY-A2A-ZM241385-Na
25.00Single5EE7MK08935EE7-Glucagon-MK0893
25.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
25.00Single5K2AZM2413855K2A-A2A-ZM241385-Na
25.00Single5OLGZM2413855OLG-A2A-ZM241385-Na
25.00Single5UENDU1725UEN-A1-DU172
25.00Single5VRAZM2413855VRA-A2A-ZM241385-Na
25.00Single6S0LZM2413856S0L-A2A-ZM241385
25.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
25.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
25.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.00Single7PYRPSB-21157PYR-A2A-PSB-2115
25.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
25.00Single8CU6LJ-45178CU6-A2A-LJ-4517
25.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
25.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
25.00Consensusa2_offOrthosteric Liganda2a_off
25.00Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
25.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
25.00Consensusclass-d_offOrthosteric Ligandste2_off
25.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
25.00Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
25.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
25.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
24.44Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
24.39Single4XT3Fractalkine4XT3-US28-Fractalkine
24.39Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
24.39Consensusclass-d_onOrthosteric Ligandste2_on
24.39Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
24.39Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
24.32Single4XT1Fractalkine4XT1-US28-Fractalkine
24.32Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
24.32Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
24.32Single7QA8Peptide7QA8-STE2-Peptide
24.32Single7QA8Peptide7QA8-STE2-Peptide
24.32Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
24.32Consensusclass-d_offOrthosteric Ligandste2_off
24.32Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
24.32Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
24.24Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
24.24Single5IUAQ274563485IUA-A2A-Q27456348-Na
24.24Single5NM2ZM2413855NM2-A2A-ZM241385-Na
24.24Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
24.24Single6LPLZM2413856LPL-A2A-ZM241385-Na
24.24Single6S0QZM2413856S0Q-A2A-ZM241385
24.24Single6WQAZM2413856WQA-A2A-ZM241385-Na
24.24Single7RM5ZM2413857RM5-A2A-ZM241385-Na
24.24Single7SINNPS-21437SIN-CaS-NPS-2143
24.24Single7SINNPS-21437SIN-CaS-NPS-2143
24.24Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
24.24Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
24.24Single8FYNZM2413858FYN-A2A-ZM241385-Na
24.24Single8GNEKW-63568GNE-A2A-KW-6356-Na
24.24Single8QOTNanobody E8QOT-μ-Nanobody E
24.24Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
24.24Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.24Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
23.91Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
23.91Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
23.91Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
23.91Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
23.81Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
23.68Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
23.68Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
23.68Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
23.68Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
23.68Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
23.53Single2YDVNECA2YDV-A2A-NECA
23.53Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
23.53Single4UHRCGS216804UHR-A2A-CGS21680
23.53Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
23.53Single5G53NECA5G53-A2A-NECA-Gs
23.53Single5V57TC1145V57-SMO-TC114
23.53Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
23.53Single7TUYGSK682753A7TUY-GPR183-GSK682753A
23.53Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
23.53Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
23.53Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
23.53Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
23.53Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
23.53Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
23.53Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
23.33Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
23.33Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
23.33Consensusgo_class-b2Orthosteric Ligandgo_adhesion
23.26Single6IGLIRL16206IGL-ETB-IRL1620
23.26Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
23.08Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
23.08Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
23.08Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
23.08Single7XNACYN1548067XNA-SST2-CYN154806
23.08Consensusangiotensin_onOrthosteric Ligandat1_on
23.08Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
23.08Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
23.08Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
23.08Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
22.86Single4N4WSANT-14N4W-SMO-SANT-1
22.86Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
22.86Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
22.86Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
22.86Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
22.86Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
22.86Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
22.86Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
22.86Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
22.86Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
22.86Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
22.86Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
22.86Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
22.86Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.86Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
22.86Consensusgi_class-fOther Ligandgi_frizzled
22.86Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
22.86Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
22.86Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
22.86Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
22.86Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
22.86Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
22.58Single5K2DZM2413855K2D-A2A-ZM241385
22.58Single5U09Taranabant5U09-CB1-Taranabant
22.58Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
22.58Single6JZHZM2413856JZH-A2A-ZM241385-Na
22.58Single6PS7ZM2413856PS7-A2A-ZM241385-Na
22.58Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.58Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.58Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
22.58Single8GNGIstradefylline8GNG-A2A-Istradefylline
22.58Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
22.58Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
22.50Single7C61Ergotamine7C61-5-HT1B-Ergotamine
22.50Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
22.50Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
22.50Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
22.50Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
22.22Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
22.22Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
22.22Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
22.22Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
22.22Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
22.22Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
22.22Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
22.22Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
22.22Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
22.22Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
22.22Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
22.22Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
22.22Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
21.95Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
21.95Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
21.95Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
21.95Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
21.95Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
21.95Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
21.95Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
21.95Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
21.95Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.95Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
21.95Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.95Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
21.88Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
21.88Single5IU4ZM2413855IU4-A2A-ZM241385-Na
21.88Single5IUBQ274563445IUB-A2A-Q27456344-Na
21.88Single5K2BZM2413855K2B-A2A-ZM241385-Na
21.88Single5K2CZM2413855K2C-A2A-ZM241385-Na
21.88Single5NLXZM2413855NLX-A2A-ZM241385-Na
21.88Single5NM4ZM2413855NM4-A2A-ZM241385-Na
21.88Single5UVIZM2413855UVI-A2A-ZM241385
21.88Single6AQFZM2413856AQF-A2A-ZM241385
21.88Single7AROLUF58337ARO-A2A-LUF5833-Na
21.88Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
21.88Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
21.88Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.88Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
21.88Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
21.62Single5ZTYAM102575ZTY-CB2-AM10257
21.62Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
21.62Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.62Single7XN9L-054,5227XN9-SST2-L-054,522
21.62Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
21.62Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
21.62Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
21.62Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.62Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.62Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
21.62Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
21.62Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
21.62Consensuslpl_offOrthosteric Ligands1p_off lpa_off
21.62Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.62Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.62Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
21.43Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
21.43Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
21.28Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
21.21Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
21.21Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
21.21Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
21.21Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
21.21Single5TGZAM65385TGZ-CB1-AM6538
21.21Single6LPJZM2413856LPJ-A2A-ZM241385-Na
21.21Single6LPKZM2413856LPK-A2A-ZM241385-Na
21.21Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
21.21Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
21.21Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
21.21Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
21.21Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
21.21Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
21.05Single7F8XNN90567F8X-CCKA-NN9056
21.05Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
21.05Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
21.05Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
21.05Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
21.05Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
21.05Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
21.05Consensussst_onOrthosteric Ligandsst2_on sst4_on
20.93Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.93Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
20.93Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
20.93Consensusendothelin_onOrthosteric Ligandetb_on eta_on
20.93Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
20.69Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
20.59Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
20.59Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
20.59Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
20.59Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
20.59Single6PS6Timolol6PS6-β2-Timolol
20.59Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
20.59Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
20.59Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
20.59Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.59Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.59Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
20.59Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
20.59Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
20.59Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
20.59Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
20.51Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
20.51Single6HLOAprepitant6HLO-NK1-Aprepitant
20.51Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
20.51Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.51Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.51Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
20.51Consensussst_offOrthosteric Ligandsst2_off
20.45Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
20.45Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
20.45Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
20.45Single8IY6Endothelin-18IY6-ETB-Endothelin-1
20.45Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
20.45Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single3OE0CVX153OE0-CXCR4-CVX15
20.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
20.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
20.00Single5XRAAM115425XRA-CB1-AM11542
20.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
20.00Single6J21Aprepitant6J21-NK1-Aprepitant
20.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
20.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
20.00Single6PT2KGCHM076PT2-δ-KGCHM07
20.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
20.00Single6WGTLSD6WGT-5-HT2A-LSD
20.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
20.00Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
20.00Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
20.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
20.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
20.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
20.00Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
20.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
20.00Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
20.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
20.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
20.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
20.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
20.00Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
20.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
20.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
20.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
20.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
20.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
20.00Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.00Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
20.00Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
20.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
20.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.00Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
20.00Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
20.00Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensuslpa_offOrthosteric Ligandlpa1_off
20.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
20.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
19.61Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
19.57Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
19.57Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
19.51Single6JODAngiotensin II6JOD-AT2-Angiotensin II
19.51Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
19.51Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
19.51Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.51Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
19.51Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
19.51Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
19.51Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
19.44Single4AMIBucindolol4AMI-β1-Bucindolol
19.44Single4XEENeurotensin4XEE-NTS1-Neurotensin
19.44Single4XESNeurotensin4XES-NTS1-Neurotensin
19.44Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
19.44Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
19.44Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
19.44Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
19.44Single6MXTSalmeterol6MXT-β2-Salmeterol
19.44Single6OS2TRV0266OS2-AT1-TRV026
19.44Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
19.44Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
19.44Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
19.44Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
19.44Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.44Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
19.44Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.44Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
19.44Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
19.44Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
19.44Single7YITNalfurafine7YIT-κ-Nalfurafine
19.44Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.44Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
19.44Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
19.44Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.44Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
19.44Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
19.44Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
19.44Single8JJLOlodaterol8JJL-β2-Olodaterol
19.44Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
19.44Single8JWZAB9288JWZ-A2A-AB928-Na
19.44Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
19.44Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
19.44Single8WU1KCA8WU1-CB1-KCA-Arrestin1
19.44Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
19.44Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
19.44Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
19.44Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
19.44Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
19.44Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
19.44Consensusdp_offOrthosteric Liganddp2_off
19.44Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
19.44Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
19.44Consensusnts_onOrthosteric Ligandnts1_on
19.44Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
19.44Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
19.35Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
19.35Single8GH1Epinephrine8GH1-β2-Epinephrine
19.35Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
19.35Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
19.05Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
19.05Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
19.05Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
18.92Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
18.92Single4BUONeurotensin4BUO-NTS1-Neurotensin
18.92Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
18.92Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
18.92Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
18.92Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
18.92Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
18.92Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.92Single7UM4AS26747237UM4-5-HT5A-AS2674723
18.92Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
18.92Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
18.92Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
18.92Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
18.92Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.92Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
18.92Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.92Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
18.92Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
18.92Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.92Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
18.92Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
18.92Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
18.92Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
18.92Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
18.92Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
18.92Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
18.92Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.92Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
18.92Consensussteroid_onOrthosteric Ligandbileacid_on
18.87Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
18.75Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
18.75Single3PWHZM2413853PWH-A2A-ZM241385
18.75Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
18.75Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
18.75Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
18.75Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
18.75Single5ZKQABT-4915ZKQ-PAF-ABT-491
18.75Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
18.75Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
18.75Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
18.75Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
18.75Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
18.75Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
18.75Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
18.75Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.75Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
18.75Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
18.75Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
18.75Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
18.75Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
18.75Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
18.60Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
18.60Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
18.42Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
18.42Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
18.42Single6PT3DPI-2876PT3-δ-DPI-287
18.42Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
18.42Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
18.42Single7SK9CCX6627SK9-ACKR3-CCX662
18.42Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
18.42Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.42Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
18.42Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
18.42Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
18.42Consensuslpl_onOrthosteric Ligands1p_on lpa_on
18.42Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
18.42Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.18Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
18.18Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
18.18Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
18.18Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
18.18Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
18.18Single7T32ZM2413857T32-A2A-ZM241385
18.18Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
18.18Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
18.18Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
18.18Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
18.18Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
18.18Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
18.18Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
18.18Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
18.18Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
18.18Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
18.18Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
18.18Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
18.18Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
18.18Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
18.18Consensusgnrh_offOrthosteric Ligandgnrh1_off
18.18Consensushca_onOrthosteric Ligandhca2_on hca3_on
18.18Consensushcar_onOrthosteric Ligandhca_on
17.95Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
17.95Single4IARErgotamine4IAR-5-HT1B-Ergotamine
17.95Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
17.95Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
17.95Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
17.95Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.95Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
17.95Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
17.95Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
17.95Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
17.78Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
17.65Single3NY8ICI 118-5513NY8-β2-ICI 118-551
17.65Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
17.65Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
17.65Single4DAJTiotropium4DAJ-M3-Tiotropium
17.65Single4EJ4Naltrindole4EJ4-δ-Naltrindole
17.65Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
17.65Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
17.65Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
17.65Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
17.65Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
17.65Single6D27CAY104716D27-DP2-CAY10471
17.65Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
17.65Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
17.65Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
17.65Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
17.65Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
17.65Single6PS1Timolol6PS1-β2-Timolol
17.65Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
17.65Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
17.65Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
17.65Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
17.65Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
17.65Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
17.65Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
17.65Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
17.65Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
17.65Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
17.65Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
17.65Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
17.65Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
17.65Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
17.65Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
17.65Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
17.65Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
17.65Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
17.65Single8JJOAlprenolol8JJO-β2-Alprenolol
17.65Single8K5DGSK2560738K5D-HCA2-GSK256073
17.65Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
17.65Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.65Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
17.65Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
17.65Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
17.65Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
17.65Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
17.65Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
17.65Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
17.65Consensusgi_hcarOrthosteric Ligandgi_hca
17.65Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
17.65Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
17.50Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
17.50Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
17.50Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
17.50Single7SK5CXCL127SK5-ACKR3-CXCL12
17.50Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
17.50Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
17.50Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
17.50Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
17.50Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
17.39Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
17.39Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
17.39Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
17.24Consensusclass-c_onOther Ligandgabab_on mglu_on
17.14Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
17.14Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
17.14Single5C1MBU725C1M-μ-BU72
17.14Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
17.14Single5TVNLSD5TVN-5-HT2B-LSD
17.14Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
17.14Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
17.14Single6LUQHaloperidol6LUQ-D2-Haloperidol
17.14Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
17.14Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
17.14Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
17.14Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
17.14Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
17.14Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
17.14Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
17.14Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
17.14Single7XKAEpinephrine7XKA-β2-Epinephrine
17.14Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.14Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.14Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
17.14Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.14Single8EA0Iperoxo8EA0-M3-Iperoxo
17.14Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
17.14Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
17.14Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
17.14Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
17.14Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
17.14Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
17.14Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
17.14Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.14Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
17.14Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
17.14Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
17.14Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
17.14Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
17.14Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
17.14Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
17.14Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
17.14Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.14Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
17.14Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
17.14Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
17.14Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
17.07Single6W25SHU91196W25-MC4-SHU9119-Ca
17.07Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
17.07Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.07Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
17.07Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
17.07Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
17.07Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
17.02Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
17.02Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.67Single3P0GBI1671073P0G-β2-BI167107
16.67Single3RFMCaffeine3RFM-A2A-Caffeine
16.67Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
16.67Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
16.67Single4BV0Neurotensin4BV0-NTS1-Neurotensin
16.67Single4RWADIPP-NH24RWA-δ-DIPP-NH2
16.67Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
16.67Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
16.67Single5V54Methiothepin5V54-5-HT1B-Methiothepin
16.67Single5XR8AM8415XR8-CB1-AM841
16.67Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
16.67Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
16.67Single6J20Aprepitant6J20-NK1-Aprepitant
16.67Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
16.67Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
16.67Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
16.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
16.67Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
16.67Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
16.67Single7F1TMIP-1a7F1T-CCR5-MIP-1a
16.67Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
16.67Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
16.67Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
16.67Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
16.67Single7P2L4YI7P2L-mGlu5-4YI
16.67Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
16.67Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
16.67Single7W41PD1762527W41-BB2-PD176252
16.67Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
16.67Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
16.67Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
16.67Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
16.67Single8A2OTheophylline8A2O-A2A-Theophylline-Na
16.67Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
16.67Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
16.67Single8E0GBU728E0G-μ-BU72
16.67Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
16.67Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
16.67Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
16.67Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
16.67Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
16.67Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
16.67Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
16.67Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
16.67Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.67Consensus5ht1_offOrthosteric Ligand5ht1b_off
16.67Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
16.67Consensus5ht5_offOrthosteric Ligand5ht5a_off
16.67Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
16.67Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
16.67Consensusbombesin_offOrthosteric Ligandbb2_off
16.67Consensusclass-d_onOrthosteric Ligandste2_on
16.67Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
16.67Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusgi_class-dOrthosteric Ligandgi_ste
16.67Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
16.67Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
16.67Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
16.67Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Consensuslpa_onOrthosteric Ligandlpa1_on
16.67Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
16.67Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
16.67Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
16.67Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
16.67Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
16.67Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
16.67Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
16.67Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
16.33Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
16.28Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
16.22Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
16.22Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
16.22Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
16.22Single5CXVTiotropium5CXV-M1-Tiotropium
16.22Single6A93Risperidone6A93-5-HT2A-Risperidone
16.22Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
16.22Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
16.22Single6CM4Risperidone6CM4-D2-Risperidone
16.22Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
16.22Single6IIURamatroban6IIU-TP-Ramatroban
16.22Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
16.22Single6YVRNTS8-136YVR-NTS1-NTS8-13
16.22Single7DFPSpiperone7DFP-D2-Spiperone
16.22Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
16.22Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
16.22Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
16.22Single7K15MKD0467K15-BLT1-MKD046-Na
16.22Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
16.22Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
16.22Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
16.22Single8JJ8Formoterol8JJ8-β2-Formoterol
16.22Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
16.22Consensusblt_offOrthosteric Ligandblt1_off
16.22Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
16.22Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
16.22Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
16.22Consensusgs_steroidOrthosteric Ligandgs_bileacid
16.22Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
16.22Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
16.22Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
16.22Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
16.22Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
16.13Single6LI0GTPL98046LI0-GPR52-GTPL9804
16.13Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
16.13Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
15.91Single7SK3CXCL127SK3-ACKR3-CXCL12
15.91Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
15.91Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
15.79Single6IBLArformoterol6IBL-β1-Arformoterol
15.79Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
15.79Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
15.79Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
15.79Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
15.79Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
15.79Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
15.79Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
15.79Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
15.79Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
15.79Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.79Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Consensusorexin_onOrthosteric Ligandox2_on
15.69Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
15.62Single3OE9IT1t3OE9-CXCR4-IT1t
15.62Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
15.62Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
15.62Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
15.62Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
15.62Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
15.62Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
15.62Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
15.62Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.62Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.62Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
15.62Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
15.62Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
15.62Single8K5BNiacin8K5B-HCA2-Niacin
15.62Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.62Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
15.38Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
15.38Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
15.38Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
15.38Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
15.38Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.15Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
15.15Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
15.15Single4BWBNeurotensin4BWB-NTS1-Neurotensin
15.15Single6AKXA4R6AKX-CCR5-A4R
15.15Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
15.15Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
15.15Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.15Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
15.15Single7F8ULintitript7F8U-CCKA-Lintitript
15.15Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
15.15Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
15.15Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
15.15Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
15.15Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
15.15Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
15.15Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
15.15Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.15Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
15.15Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
15.15Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Single8IWESpermidine8IWE-TAAR9-Spermidine
15.15Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
15.15Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.15Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.15Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.15Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.15Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.15Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
15.15Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
15.15Consensusclass-f_offOrthosteric Ligandsmo_off
15.15Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
15.15Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
15.15Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.15Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.15Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.15Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
15.15Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
15.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
15.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
15.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
15.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
15.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
15.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
14.89Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
14.81Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
14.71Single3REYPubChem 56973REY-A2A-PubChem 5697
14.71Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
14.71Single4MBSMaraviroc4MBS-CCR5-Maraviroc
14.71Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
14.71Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
14.71Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
14.71Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
14.71Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
14.71Single6PS4ICI 118-5516PS4-β2-ICI 118-551
14.71Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
14.71Single6TPKRetosiban6TPK-OT-Retosiban
14.71Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
14.71Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
14.71Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
14.71Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
14.71Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
14.71Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
14.71Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.71Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
14.71Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
14.71Single7VODCariprazine7VOD-5-HT2A-Cariprazine
14.71Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
14.71Single7VV6C48/807VV6-MRGPRX2-C48/80
14.71Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
14.71Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
14.71Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
14.71Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.71Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.71Single8GGKEpinephrine8GGK-β2-Epinephrine
14.71Single8GGLEpinephrine8GGL-β2-Epinephrine
14.71Single8GGMEpinephrine8GGM-β2-Epinephrine
14.71Single8GGPEpinephrine8GGP-β2-Epinephrine
14.71Single8GGQEpinephrine8GGQ-β2-Epinephrine
14.71Single8GGTEpinephrine8GGT-β2-Epinephrine
14.71Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
14.71Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
14.71Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
14.71Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
14.71Single8K5CAcipimox8K5C-HCA2-Acipimox
14.71Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.71Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
14.71Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.71Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.71Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.71Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.71Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
14.71Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
14.71Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
14.71Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
14.71Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
14.71Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
14.71Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
14.71Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
14.71Consensusvasopressin-ot_offOrthosteric Ligandot_off
14.63Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
14.63Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
14.63Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
14.63Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
14.63Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.63Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
14.58Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
14.29Single2Y02Carmoterol2Y02-β1-Carmoterol
14.29Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
14.29Single4MQSIperoxo4MQS-M2-Iperoxo
14.29Single4U14Tiotropium4U14-M3-Tiotropium
14.29Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
14.29Single5DSGTiotropium5DSG-M4-Tiotropium
14.29Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
14.29Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
14.29Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
14.29Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
14.29Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
14.29Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
14.29Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
14.29Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
14.29Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
14.29Single6TOTLemborexant6TOT-OX1-Lemborexant
14.29Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
14.29Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
14.29Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
14.29Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
14.29Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
14.29Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
14.29Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
14.29Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
14.29Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
14.29Single7UL4Alvimopan7UL4-μ-Alvimopan
14.29Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
14.29Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
14.29Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
14.29Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
14.29Single7WC7Lisuride7WC7-5-HT2A-Lisuride
14.29Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
14.29Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
14.29Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GGJEpinephrine8GGJ-β2-Epinephrine
14.29Single8GGNEpinephrine8GGN-β2-Epinephrine
14.29Single8GGOEpinephrine8GGO-β2-Epinephrine
14.29Single8GGUEpinephrine8GGU-β2-Epinephrine
14.29Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
14.29Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
14.29Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
14.29Single8X63Mepyramine8X63-H1-Mepyramine
14.29Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
14.29Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
14.29Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
14.29Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
14.29Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
14.29Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
14.29Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
14.29Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
14.29Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
14.29Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
14.29Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
14.29Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
14.29Consensushistamine_onOrthosteric Ligandh1_on h4_on
14.29Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
14.29Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
14.29Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
14.29Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
14.29Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
14.29Consensustachykinin_offOrthosteric Ligandnk1_off
14.29Consensustar_onOrthosteric Ligandta1_on
13.89Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
13.89Single5CGCHTL142425CGC-mGlu5-HTL14242
13.89Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
13.89Single6D26Fevipiprant6D26-DP2-Fevipiprant
13.89Single6E67BI1671076E67-β2-BI167107-Gs (fused)
13.89Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
13.89Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
13.89Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
13.89Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
13.89Single6TP6Filorexant6TP6-OX1-Filorexant
13.89Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
13.89Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
13.89Single7C4SS1P7C4S-S1P3-S1P
13.89Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
13.89Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
13.89Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
13.89Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
13.89Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
13.89Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
13.89Single7WC6LSD7WC6-5-HT2A-LSD
13.89Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
13.89Single7YXAONO-54306087YXA-S1P5-ONO-5430608
13.89Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
13.89Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
13.89Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
13.89Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
13.89Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
13.89Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
13.89Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
13.89Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
13.89Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
13.89Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
13.89Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
13.89Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
13.89Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
13.89Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
13.89Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.89Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.51Single4DJHJDTic4DJH-κ-JDTic
13.51Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
13.51Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
13.51Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
13.51Single4U15Tiotropium4U15-M3-Tiotropium
13.51Single6E59L-7607356E59-NK1-L-760735
13.51Single6H7JIsoprenaline6H7J-β1-Isoprenaline
13.51Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
13.51Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
13.51Single6OL9Tiotropium6OL9-M5-Tiotropium
13.51Single6OS1TRV0266OS1-AT1-TRV026
13.51Single6TQ7SB-3348676TQ7-OX1-SB-334867
13.51Single7B6WCyclazosin7B6W-α1b-Cyclazosin
13.51Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
13.51Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
13.51Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
13.51Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
13.51Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
13.51Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
13.51Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
13.51Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
13.51Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.51Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.51Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
13.51Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
13.51Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
13.51Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
13.51Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
13.51Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
13.51Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
13.51Consensuschemerin_onOrthosteric Ligandcml1_on
13.51Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
13.51Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
13.51Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
13.51Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
13.51Consensushistamine_offOrthosteric Ligandh1_off
13.51Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
13.51Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
13.51Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
13.51Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.33Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
13.33Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
13.33Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
13.33Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
13.33Single8PWNTheophylline8PWN-A2A-Theophylline
13.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
13.33Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
13.16Single4LDEBI1671074LDE-β2-BI167107
13.16Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
13.16Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
13.16Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
13.16Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
13.16Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
13.16Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.16Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
13.16Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.16Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.16Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.16Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
13.16Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
13.16Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
13.16Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
13.16Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
13.16Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.16Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.04Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
12.90Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
12.82Single5CGDHTL142425CGD-mGlu5-HTL14242
12.82Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
12.82Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
12.82Single6H7LDobutamine6H7L-β1-Dobutamine
12.82Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
12.82Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
12.82Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.82Consensusendothelin_offOrthosteric Ligandetb_off
12.82Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
12.82Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.82Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.82Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
12.50Single3OE6IT1t3OE6-CXCR4-IT1t
12.50Single3UZAGTPL92363UZA-A2A-GTPL9236
12.50Single4XNWMRS25004XNW-P2Y1-MRS2500
12.50Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
12.50Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
12.50Single6KNMJN241-96KNM-Apelin-JN241-9
12.50Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
12.50Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
12.50Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
12.50Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
12.50Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
12.50Single8GGREpinephrine8GGR-β2-Epinephrine
12.50Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
12.50Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
12.50Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
12.50Single8X5YAstemizole8X5Y-H1-Astemizole
12.50Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
12.50Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
12.50Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
12.50Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
12.20Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
12.20Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
12.20Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
12.20Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
12.20Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
12.20Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
12.12Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
12.12Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
12.12Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
12.12Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.12Single5L7IVismodegib5L7I-SMO-Vismodegib
12.12Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
12.12Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
12.12Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
12.12Single6HLLCP999946HLL-NK1-CP99994
12.12Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
12.12Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
12.12Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
12.12Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
12.12Single7SRQLSD7SRQ-5-HT2B-LSD
12.12Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
12.12Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
12.12Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
12.12Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
12.12Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.12Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
12.12Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
12.12Single8GGSEpinephrine8GGS-β2-Epinephrine
12.12Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
12.12Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.12Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.12Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
12.12Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
12.12Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.12Consensusgo_proteinOrthosteric Ligandgo_chemokine
12.12Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
12.12Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.76Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
11.76Single3ODUIT1t3ODU-CXCR4-IT1t
11.76Single4QINSAG1.54QIN-SMO-SAG1.5
11.76Single4S0VSuvorexant4S0V-OX2-Suvorexant
11.76Single6AKYMaraviroc6AKY-CCR5-Maraviroc
11.76Single6B73PubChem 1319551386B73-κ-PubChem 131955138
11.76Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
11.76Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
11.76Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.76Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.76Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
11.76Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
11.76Single6TODEMPA6TOD-OX1-EMPA-Na
11.76Single6TPJSuvorexant6TPJ-OX2-Suvorexant
11.76Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
11.76Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.76Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
11.76Single7F8YDevazepide7F8Y-CCKA-Devazepide
11.76Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
11.76Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
11.76Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
11.76Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
11.76Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
11.76Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
11.76Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
11.76Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
11.76Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
11.76Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
11.76Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
11.76Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.76Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
11.76Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
11.76Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
11.76Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.76Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.76Single8GGVEpinephrine8GGV-β2-Epinephrine
11.76Single8GGWEpinephrine8GGW-β2-Epinephrine
11.76Single8GGXEpinephrine8GGX-β2-Epinephrine
11.76Single8GH0Epinephrine8GH0-β2-Epinephrine
11.76Single8IHKAcifran8IHK-HCA3-Acifran
11.76Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
11.76Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.76Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
11.76Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
11.76Consensusalpha1_onOrthosteric Ligandalpha1a_on
11.76Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
11.76Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
11.76Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.76Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Consensusgt_class-aOrthosteric Ligandgt_opsin
11.76Consensusgt_opsinOrthosteric Ligandgt_sensory
11.76Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
11.76Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
11.76Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
11.76Consensusorexin_offOrthosteric Ligandox2_off ox1_off
11.76Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.63Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.43Single3RZECidoxepin3RZE-H1-Cidoxepin
11.43Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
11.43Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
11.43Single4ZJCSB-6740424ZJC-OX1-SB-674042
11.43Single6A94Zotepine6A94-5-HT2A-Zotepine
11.43Single6DS0Ly2660976DS0-5-HT2B-Ly266097
11.43Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
11.43Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
11.43Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
11.43Single6TP3Nemorexant6TP3-OX1-Nemorexant
11.43Single6TPGEMPA6TPG-OX2-EMPA
11.43Single6TPNHTL66416TPN-OX2-HTL6641
11.43Single6V9SGTPL114036V9S-OX1-GTPL11403
11.43Single6VI4JDTic6VI4-κ-JDTic
11.43Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.43Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
11.43Single6ZG9GSK10347026ZG9-M1-GSK1034702
11.43Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
11.43Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
11.43Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
11.43Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
11.43Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
11.43Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
11.43Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
11.43Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
11.43Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
11.43Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
11.43Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.43Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.43Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
11.43Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
11.43Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
11.43Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
11.43Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
11.43Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
11.43Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
11.43Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
11.43Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
11.43Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
11.43Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
11.43Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.43Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.43Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.43Single8GGIEpinephrine8GGI-β2-Epinephrine
11.43Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
11.43Single8K2WAMG4878K2W-CXCR3-AMG487
11.43Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
11.43Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.43Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.43Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
11.43Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
11.43Consensus5ht5_onOrthosteric Ligand5ht5a_on
11.43Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
11.43Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
11.43Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
11.43Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
11.43Consensusgi_class-fOrthosteric Ligandgi_frizzled
11.43Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.43Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
11.43Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
11.43Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
11.43Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
11.43Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
11.43Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
11.43Consensuss1p_offOrthosteric Ligands1p1_off
11.43Consensussensory_offOrthosteric Ligandopsin_off
11.36Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
11.11Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
11.11Single2Y04Salbutamol2Y04-β1-Salbutamol
11.11Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
11.11Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
11.11Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
11.11Single4YAYZD-71554YAY-AT1-ZD-7155
11.11Single5T04Neurotensin5T04-NTS1-Neurotensin
11.11Single6DRXLisuride6DRX-5-HT2B-Lisuride
11.11Single6H7MSalbutamol6H7M-β1-Salbutamol
11.11Single6IIVDaltroban6IIV-TP-Daltroban
11.11Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
11.11Single7BU7BI1671077BU7-β1-BI167107
11.11Single7F83PF-051904577F83-Ghrelin-PF-05190457
11.11Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
11.11Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
11.11Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
11.11Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
11.11Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
11.11Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
11.11Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
11.11Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
11.11Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
11.11Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
11.11Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
11.11Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
11.11Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
11.11Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
11.11Single8X64Desloratadine8X64-H1-Desloratadine
11.11Consensuscck_offOrthosteric Ligandccka_off
11.11Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
11.11Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
11.11Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
11.11Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
11.11Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
11.11Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
11.11Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
11.11Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
10.87Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
10.81Single2Y03Isoprenaline2Y03-β1-Isoprenaline
10.81Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
10.81Single5WQCEMPA5WQC-OX2-EMPA
10.81Single5XPRBosentan5XPR-ETB-Bosentan
10.81Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
10.81Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
10.81Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
10.81Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
10.81Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
10.81Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
10.81Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
10.81Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.81Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
10.81Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
10.81Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
10.81Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
10.81Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
10.81Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
10.81Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
10.81Consensusep_offOrthosteric Ligandep4_off
10.64Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.53Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
10.53Single5TZR-5TZR-FFA1 (GPR40)-MK8666
10.53Single5X93K-87945X93-ETB-K-8794
10.53Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
10.53Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
10.53Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
10.53Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
10.53Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
10.53Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
10.53Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
10.53Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
10.53Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
10.53Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
10.34Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
10.34Single8HS2Fab0468HS2-GPR20-Fab046
10.26Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
10.26Single6HLPNetupitant6HLP-NK1-Netupitant
10.26Single6ZG4HTL00099366ZG4-M1-HTL0009936
10.26Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
10.26Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.26Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.26Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
10.26Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
10.26Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
10.26Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
10.26Consensuschemokine_offOrthosteric Ligandcxcr_off
10.26Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
10.26Consensuscxcr_offOrthosteric Ligandcxcr4_off
10.26Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
10.26Consensusnts_offOrthosteric Ligandnts1_off
10.20Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
10.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
10.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
10.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
10.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
10.00Single6K1QIRL25006K1Q-ETB-IRL2500
10.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
10.00Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
9.76Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
9.68Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
9.68Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
9.52Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
9.52Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
9.38Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
9.38Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.38Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
9.38Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.38Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
9.38Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
9.38Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
9.38Consensussensory_onOrthosteric Ligandopsin_on
9.30Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
9.09Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
9.09Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
9.09Single3OE8IT1t3OE8-CXCR4-IT1t
9.09Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
9.09Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
9.09Single6ME5Agomelatine6ME5-MT1-Agomelatine
9.09Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
9.09Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
9.09Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
9.09Single7WC5Psilocin7WC5-5-HT2A-Psilocin
9.09Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8GGZEpinephrine8GGZ-β2-Epinephrine
9.09Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
9.09Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
9.09Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
9.09Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
9.09Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
9.09Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
8.89Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
8.82Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
8.82Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
8.82Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
8.82Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
8.82Single3PBLEticlopride3PBL-D3-Eticlopride
8.82Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
8.82Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.82Single7UL2SR486927UL2-NTS1-SR48692-Na
8.82Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
8.82Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
8.82Single8GGYEpinephrine8GGY-β2-Epinephrine
8.82Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
8.82Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
8.82Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
8.82Consensusclass-t_onOrthosteric Ligandtaste2_on
8.82Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
8.82Consensusgs_class-tOrthosteric Ligandgs_taste
8.82Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
8.82Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
8.82Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
8.82Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
8.82Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
8.82Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
8.57Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
8.57Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
8.57Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
8.57Single5DHHSB-6121115DHH-NOP-SB-612111
8.57Single5WS3EMPA5WS3-OX2-EMPA
8.57Single6KUXRS-799486KUX-α2a-RS-79948
8.57Single6ME2Ramelteon6ME2-MT1-Ramelteon
8.57Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
8.57Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
8.57Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
8.57Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
8.57Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
8.57Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
8.57Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
8.57Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
8.57Single7XRRLemborexant7XRR-OX2-Lemborexant
8.57Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
8.57Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
8.57Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
8.57Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
8.57Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.57Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
8.57Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
8.57Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
8.33Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
8.33Single6FFIMMPEP6FFI-mGlu5-MMPEP
8.33Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
8.33Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
8.33Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
8.33Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
8.33Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
8.33Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
8.11Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
8.11Single2Y01Dobutamine2Y01-β1-Dobutamine
8.11Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
8.11Single6FFHFenobam6FFH-mGlu5-Fenobam
8.11Single6GPSMK08126GPS-CCR2-MK0812
8.11Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
8.11Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
8.11Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
8.11Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
8.11Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
8.11Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
8.11Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
8.11Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
8.11Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
8.11Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
8.11Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
8.11Consensusblt_onOrthosteric Ligandblt1_on
8.11Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
8.11Consensushcar_offOrthosteric Ligandsuccinate_off
8.11Consensusleuko_onOrthosteric Ligandblt_on
8.11Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
8.11Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
7.89Single2Y00Dobutamine2Y00-β1-Dobutamine
7.89Single4NTJAZD12834NTJ-P2Y12-AZD1283
7.89Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
7.89Single5WIUNemonapride5WIU-D4-Nemonapride
7.89Single5WIVNemonapride5WIV-D4-Nemonapride-Na
7.89Single6GPXMK08126GPX-CCR2-MK0812
7.89Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
7.89Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
7.89Single6Z4SSR486926Z4S-NTS1-SR48692
7.89Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
7.89Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
7.69Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
7.69Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.50Single4PY02MeSATP4PY0-P2Y12-2MeSATP
7.50Single5X33BIIL2605X33-BLT1-BIIL260
7.50Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
7.50Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
7.50Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.50Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.32Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
7.32Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
7.32Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
7.32Consensuscyslt_offOrthosteric Ligandcyslt2_off
6.98Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
6.82Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.45Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.45Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
6.25Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
6.25Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
6.25Single7WC4Serotonin7WC4-5-HT2A-Serotonin
6.25Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
6.06Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
6.06Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
5.88Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
5.88Single6ME9Ramelteon6ME9-MT2-Ramelteon
5.88Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.88Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
5.71Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
5.71Single6TP4ACT-4622066TP4-OX1-ACT-462206
5.71Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
5.71Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
5.71Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
5.71Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
5.71Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
5.56Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
5.41Single6IQLL7458706IQL-D4-L745870
5.41Single6ZINSR486926ZIN-NTS1-SR48692
5.41Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
5.41Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
5.41Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.26Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
5.26Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.44Single7SHEPI; PE7SHE-GPR158-PI; PE
4.44Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.45Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
3.45Single6D35Cholesterol6D35-SMO-Cholesterol
3.45Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.45Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.45Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
3.45Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
3.45Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
3.45Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.45Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.45Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
3.45Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
3.45Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
3.45Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.45Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.45Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.45Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.45Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
3.45Single7DTTCa7DTT-CaS-Ca-Ca
3.45Single7DTTCa7DTT-CaS-Ca-Ca
3.45Single7DTUTryptophan7DTU-CaS-Tryptophan
3.45Single7DTUTryptophan7DTU-CaS-Tryptophan
3.45Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.45Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.45Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.45Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.45Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.45Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.45Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.45Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.45Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.45Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.45Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
3.45Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
3.45Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
3.45Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.45Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.45Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.45Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.45Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.45Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.45Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
3.45Single7FIIhCG7FII-LH-hCG-6fuf
3.45Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
3.45Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
3.45Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.45Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.45Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.45Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.45Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.45Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.45Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.45Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.45Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.45Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.45Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
3.45Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
3.45Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.45Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.45Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.45Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.45Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.45Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.45Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.45Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.45Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
3.45Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.45Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.45Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.45Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.45Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.45Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.45Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
3.45Single7XW7K1-707XW7-TSH-K1-70
3.45Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.45Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.45Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.45Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.45Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.45Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.45Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.45Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.45Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.45Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.45Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.45Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.45Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
3.45Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.45Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.45Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.45Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.45Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
3.45Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
3.45Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.45Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.45Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.45Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.45Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.45Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.45Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.45Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.45Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.45Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
3.45Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
3.45Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
3.45Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
3.45Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.45Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.45Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.45Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.45Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.45Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.45Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.45Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.45Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.45Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.45Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.45Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.45Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
3.45Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
3.45Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
3.45Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
3.45Consensusclass-c_offOther Ligandgabab_off mglu_off
3.45Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
3.45Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
3.45Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
3.45Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
3.45Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
3.45Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
3.45Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
3.45Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
3.45Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.45Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.45Consensusgphr_onOrthosteric Ligandlh_on tsh_on
3.45Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
3.45Consensusgs_proteinOrthosteric Ligandgs_gphr
3.45Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
3.45Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
3.45Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
3.45Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
3.45Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.45Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.45Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
3.45Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
3.45Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.45Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.45Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
3.45Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
3.45Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
3.45Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
3.45Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
3.45Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
3.45Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
3.45Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
3.45Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
3.33Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.33Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.33Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.33Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.33Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.33Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
3.33Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
3.23Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
3.23Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
3.12Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
3.12Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
3.12Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.12Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
3.12Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
3.12Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
3.12Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
3.12Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
3.12Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
3.03Single5L7DCholesterol5L7D-SMO-Cholesterol
3.03Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
3.03Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
2.94Single6TQ9SB-4081246TQ9-OX1-SB-408124
2.94Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
2.86Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
2.86Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
2.86Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
2.86Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
2.86Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
2.78Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
2.78Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
2.78Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
2.70Single4K5YCP-3763954K5Y-CRF1-CP-376395
2.70Single4XNVBPTU4XNV-P2Y1-BPTU
2.70Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.70Single8HNNSCH5467388HNN-CXCR3-SCH546738
2.70Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
2.70Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
2.63Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.56Single4Z9GCP-3763954Z9G-CRF1-CP-376395
2.56Single8GTIBMK-C2058GTI-CRF1-BMK-C205
2.50Single8GTGBMK-I1528GTG-CRF1-BMK-I152
2.38Single7SHEPI; PE7SHE-GPR158-PI; PE
2.38Single8GTMBMK-C2038GTM-CRF1-BMK-C203
2.33Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
gs_class-b1 gs_glucagon
gs_vip-pacap
gs_pth
gs_calcitonin
gs_crf
gs_class-b2 gs_adgr
Net Summary
Imin 3.59136
Number of Linked Nodes 1075
Number of Links 1217
Number of Hubs 175
Number of Links mediated by Hubs 728
Number of Communities 17
Number of Nodes involved in Communities 203
Number of Links involved in Communities 294
Path Summary
Number Of Nodes in MetaPath 138
Number Of Links MetaPath 137
Number of Shortest Paths 2056616
Length Of Smallest Path 3
Average Path Length 31.4551
Length of Longest Path 78
Minimum Path Strength 0.114285
Average Path Strength 7.13352
Maximum Path Strength 24.5188
Minimum Path Correlation 0.7
Average Path Correlation 0.973169
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.49254
Average % Of Corr. Nodes 39.2752
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 55.7603
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .




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