Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x50 2.804509
22x38 3.395437
32x42 6.61555638
42x47 3.96083409
52x53 4.574508
62x57 2.69333466
72x58 3.32917469
82x61 1.58333406
9E1 6.84926914
103x29 6.10583415
113x33 5.69667516
123x36 7.3775416
133x40 3.93167418
143x42 6.818548
153x47 4.13583419
163x49 3.06083439
173x51 6.93583429
183x55 6.24417426
194x42 3.62436
204x50 6.00333649
214x56 6.52333415
22E2 8.411251614
235x39 8.27111617
245x43 6.27714716
255x47 3.38583417
265x58 2.316519
275x62 2.17667407
285x69 4.11167405
295x76 3.73833403
30I3 4.165482
316x44 3.062509
326x48 6.45111618
336x51 4.90222617
34E3 3.71583852
357x49 5.61409
368x50 9.18333477
37Lig 6.289331510
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
11x39 2x58 12.02023.56NoYes079
22x57 2x58 18.43883.28YesYes669
32x54 2x57 28.27251.71NoYes096
41x46 2x54 28.71921.76333NoNo089
51x46 1x50 31.8112.36NoYes089
61x50 7x51 10.35093.44667YesNo096
71x50 2x47 25.37472.74667YesYes099
81x51 2x51 13.95993.69NoNo056
91x51 1x55 12.25530.923333NoNo054
101x55 1x56 10.5390.57NoNo048
112x43 2x47 20.47267.30667NoYes089
122x43 8x50 17.145712.0333NoYes087
131x57 8x50 12.25535.24NoYes087
141x50 2x50 77.69352.26333YesNo099
152x50 2x53 78.85733.03333NoYes098
162x53 3x39 62.7996.38667YesNo089
172x49 3x39 62.12312.62667NoNo099
182x49 3x42 35.23784.69NoYes498
192x45 3x42 29.10727.94667NoYes498
202x45 4x46 44.3723NoNo097
212x42 4x46 41.86215.27667YesNo087
222x38 2x42 17.01643.36667YesYes378
232x37 2x38 12.95481.95NoYes037
242x49 4x50 25.80972.59NoYes499
252x45 4x50 17.76886.18NoYes499
263x42 4x49 29.17774.39YesNo086
273x45 4x49 27.620111.3NoNo066
282x42 3x45 26.062417.8633YesNo086
292x42 3x49 17.15756.60667YesYes389
302x42 4x42 25.66863.34667YesYes386
312x46 7x50 30.48846.57NoNo099
322x53 3x36 1004.75667YesYes086
333x36 Lig 49.779614.0667YesYes160
34E1 Lig 10.32159.86333YesYes140
35E2 Lig 36.18414.99333YesYes140
363x33 Lig 12.08494.37667YesYes160
375x43 Lig 15.67049.49YesYes160
383x37 5x43 12.18484.42NoYes176
393x36 6x51 49.47395.84333YesYes167
403x37 4x53 18.00982.73333NoNo078
416x48 6x51 75.92436.43YesYes187
423x43 6x48 25.27484.55667NoYes198
433x43 3x47 22.67095.99667NoYes199
443x47 3x50 21.27783.76333YesNo199
456x44 6x48 65.355.68YesYes098
465x58 6x44 60.71833.08YesYes099
473x50 5x58 23.38212.64NoYes199
483x50 5x61 41.73285.23NoNo099
493x54 5x61 38.79973.20667NoNo089
503x54 3x55 26.88532.98NoYes286
513x51 3x55 18.08039.77YesYes296
524x52 4x53 10.83884.06NoNo028
536x51 6x55 45.59453.51667YesNo075
545x44 6x55 53.72954.47NoNo045
555x44 5x45 26.82655.89NoNo045
565x41 5x45 22.75913.31NoNo065
575x44 6x59 24.9754.81NoNo046
585x41 6x59 22.94132.94333NoNo066
595x41 6x63 41.52126.73333NoNo061
605x51 6x48 10.5394.49667NoYes078
615x58 5x62 39.09361YesYes097
625x62 6x33 29.73020.886667YesNo077
635x69 6x33 26.90887.09667YesNo057
645x69 6x29 19.57333.23YesNo056
656x25 6x29 14.84756.46NoNo036
665x76 6x25 13.23693.09667YesNo033
677x49 7x50 34.57364.12YesNo099
687x38 Lig 13.44272.46333NoYes070
696x54 7x38 11.70282.45667NoNo057
706x63 E3 37.59483.87667NoYes512
717x34 E3 12.77855.93333NoYes522
724x42 4x43 17.34561.67YesNo061
734x41 4x43 13.02530.44NoNo061
741x50 2x51 17.81583.20333YesNo096
752x46 3x42 27.25562.75NoYes098
766x48 7x49 35.843211.85YesYes089
776x51 Lig 38.26494.27333YesYes170
785x47 6x55 10.08645.07667YesNo075
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x533x364.756670YesYes8621
2x607x4231NoNo7811
2x60Lig6.973331NoYes7010
2x63E13.293331NoYes5411
2x63Lig7.091NoYes5010
E1E110.471YesYes4411
E1Lig9.863331YesYes4010
3x28E16.396671NoYes5421
E1E210.61671YesYes4411
3x24E14.390NoYes3421
3x25E14.643331NoYes9421
3x22E227.62671NoYes4421
3x253x292.691NoYes9522
3x25E2x507.281NoNo9922
3x29E2x528.481YesNo5521
3x29E210.51671YesYes5421
3x30E24.133331NoYes5421
3x333x373.663331YesNo6712
3x33E23.626671YesYes6411
3x335x395.423331YesYes6712
3x335x4311.39331YesYes6611
3x33Lig4.376671YesYes6010
3x366x515.843331YesYes6711
3x367x424.843331YesNo6811
3x36Lig14.06671YesYes6010
3x375x434.421NoYes7621
3x406x485.693331YesYes8822
3x406x513.123331YesYes8721
4x565x3911.34671YesYes5722
4x565x436.221YesYes5621
4x59E24.176671NoYes5421
5x36E210.291NoYes5421
5x39E27.663331YesYes7421
E2E216.341YesYes4411
E2E2x515.416671YesNo4412
E2E2x502.726671YesNo4912
E2E2x523.806671YesNo4511
E2x52Lig4.016671NoYes5010
6x62E25.881NoYes4411
E2Lig4.993331YesYes4010
5x365x395.563331NoYes5722
5x395x437.111YesYes7621
5x406x628.211NoNo5411
5x40Lig8.046671NoYes5010
5x435x472.653331YesYes6711
5x43Lig9.491YesYes6010
5x476x555.076671YesNo7512
5x47Lig2.583331YesYes7010
6x486x516.431YesYes8721
6x516x553.516671YesNo7512
6x517x466.226671YesNo7912
6x51Lig4.273331YesYes7010
6x58Lig9.140NoYes5010
6x62Lig4.081NoYes4010
7x42Lig2.883331NoYes8010
2x633x292.736671NoYes5512
3x405x473.231YesYes8721
5x405x432.653331NoYes5611
7x38Lig2.463330NoYes7010
6x547x382.456670NoNo5721
3x21E11.50NoYes5421
6x64E20.4266670NoYes2421

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
93.33Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
93.33Consensusgs_steroidOrthosteric Ligandgs_bileacid
86.67Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
68.75Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
62.50Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
52.17Single6JODAngiotensin II6JOD-AT2-Angiotensin II
50.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
50.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
50.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
50.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
50.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
50.00Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
50.00Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
50.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
50.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
47.83Consensusangiotensin_onOrthosteric Ligandat1_on
47.83Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
47.83Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
47.62Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
47.62Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
47.62Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
47.37Consensusrelaxin_onOrthosteric Ligandrxfp4_on
47.06Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
47.06Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
46.67Single8GGZEpinephrine8GGZ-β2-Epinephrine
45.83Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
45.83Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
45.83Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
45.45Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
45.45Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
45.45Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
45.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
45.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
45.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
45.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
45.00Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
44.44Single4EJ4Naltrindole4EJ4-δ-Naltrindole
44.44Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
44.44Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
44.44Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
44.44Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
44.44Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
44.44Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
44.44Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
44.44Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
44.44Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
44.44Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
44.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
43.75Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
43.75Single8GGYEpinephrine8GGY-β2-Epinephrine
43.75Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
43.48Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
42.86Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
42.86Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
42.86Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
42.86Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
42.86Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
42.86Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
42.86Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
42.11Single5WIUNemonapride5WIU-D4-Nemonapride
42.11Single5WIVNemonapride5WIV-D4-Nemonapride-Na
42.11Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
42.11Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
42.11Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
42.11Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
42.11Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
42.11Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
42.11Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
42.11Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single6PT2KGCHM076PT2-δ-KGCHM07
41.67Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
41.18Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
41.18Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
41.18Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
41.18Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
41.18Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
41.18Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GGVEpinephrine8GGV-β2-Epinephrine
41.18Single8GGWEpinephrine8GGW-β2-Epinephrine
41.18Single8GGXEpinephrine8GGX-β2-Epinephrine
41.18Single8GH0Epinephrine8GH0-β2-Epinephrine
41.18Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
41.18Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
41.18Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
41.18Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
40.91Single3NY9PubChem 9131033NY9-β2-PubChem 913103
40.91Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
40.91Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
40.91Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
40.91Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
40.00Single2YDVNECA2YDV-A2A-NECA
40.00Single4UHRCGS216804UHR-A2A-CGS21680
40.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
40.00Single5G53NECA5G53-A2A-NECA-Gs
40.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
40.00Single6J21Aprepitant6J21-NK1-Aprepitant
40.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
40.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
40.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
40.00Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
40.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
40.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
40.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
40.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
40.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
40.00Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
40.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
40.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
39.29Single6IGLIRL16206IGL-ETB-IRL1620
39.29Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
39.13Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
39.13Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
39.13Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
39.13Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
39.13Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
39.13Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
39.13Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
39.13Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
38.89Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
38.89Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
38.89Single6PS4ICI 118-5516PS4-β2-ICI 118-551
38.89Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
38.89Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
38.89Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
38.89Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
38.89Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
38.89Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
38.89Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
38.89Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
38.89Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
38.89Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GGIEpinephrine8GGI-β2-Epinephrine
38.89Single8GGQEpinephrine8GGQ-β2-Epinephrine
38.89Single8GGTEpinephrine8GGT-β2-Epinephrine
38.89Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
38.89Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
38.89Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
38.89Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
38.89Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
38.89Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
38.89Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
38.46Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
38.46Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.10Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
38.10Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
38.10Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
38.10Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
38.10Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.10Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
38.10Single7YITNalfurafine7YIT-κ-Nalfurafine
38.10Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
38.10Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
38.10Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
38.10Single8JWZAB9288JWZ-A2A-AB928-Na
38.10Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
38.10Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
38.10Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
38.10Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
38.10Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
38.10Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
38.10Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
37.50Single3QAKUK-4320973QAK-A2A-UK-432097
37.50Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
37.50Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
37.50Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
37.50Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
37.50Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
37.50Single8GGREpinephrine8GGR-β2-Epinephrine
37.50Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
37.50Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
37.04Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
37.04Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
36.84Single2Y04Salbutamol2Y04-β1-Salbutamol
36.84Single3NY8ICI 118-5513NY8-β2-ICI 118-551
36.84Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
36.84Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
36.84Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
36.84Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
36.84Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
36.84Single6H7MSalbutamol6H7M-β1-Salbutamol
36.84Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
36.84Single6TOTLemborexant6TOT-OX1-Lemborexant
36.84Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
36.84Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
36.84Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
36.84Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
36.84Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
36.84Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
36.84Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
36.84Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
36.84Single7UL4Alvimopan7UL4-μ-Alvimopan
36.84Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
36.84Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
36.84Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
36.84Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
36.84Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
36.84Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8GGJEpinephrine8GGJ-β2-Epinephrine
36.84Single8GGNEpinephrine8GGN-β2-Epinephrine
36.84Single8GGOEpinephrine8GGO-β2-Epinephrine
36.84Single8GGUEpinephrine8GGU-β2-Epinephrine
36.84Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
36.84Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
36.84Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
36.84Single8K5DGSK2560738K5D-HCA2-GSK256073
36.84Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
36.84Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
36.84Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
36.84Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
36.84Consensusadenosine_onOrthosteric Liganda1_on a2_on
36.84Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
36.84Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
36.84Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
36.84Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
36.84Consensusgi_hcarOrthosteric Ligandgi_hca
36.84Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
36.84Consensusnucleotide_onOrthosteric Ligandadenosine_on
36.84Consensustar_onOrthosteric Ligandta1_on
36.36Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
36.36Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
36.36Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
36.36Single6H7LDobutamine6H7L-β1-Dobutamine
36.36Single7EZCUKA7EZC-A2A-UKA
36.36Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
36.36Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
36.36Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
36.36Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
36.36Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
36.36Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
36.36Consensusendothelin_offOrthosteric Ligandetb_off
36.36Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
36.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
36.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
36.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
36.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
36.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
35.71Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
35.29Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
35.29Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
35.29Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
35.29Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GGSEpinephrine8GGS-β2-Epinephrine
35.29Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
35.29Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
35.29Single8K5BNiacin8K5B-HCA2-Niacin
35.29Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.00Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
35.00Single2Y00Dobutamine2Y00-β1-Dobutamine
35.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
35.00Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
35.00Single5C1MBU725C1M-μ-BU72
35.00Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
35.00Single5N2SPSB365N2S-A1-PSB36
35.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
35.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
35.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
35.00Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
35.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
35.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
35.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
35.00Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
35.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
35.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
35.00Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
35.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
35.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
35.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
35.00Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
35.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
35.00Single7WC6LSD7WC6-5-HT2A-LSD
35.00Single7XKAEpinephrine7XKA-β2-Epinephrine
35.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
35.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
35.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
35.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
35.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
35.00Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.00Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
35.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
35.00Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
35.00Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
35.00Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
35.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
35.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
35.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
35.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
35.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
35.00Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
35.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
35.00Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.78Single4UG2CGS216804UG2-A2A-CGS21680
34.78Single5WF6UK-4320975WF6-A2A-UK-432097
34.78Single6PT3DPI-2876PT3-δ-DPI-287
34.78Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
34.78Single7SK9CCX6627SK9-ACKR3-CCX662
34.78Single7XN9L-054,5227XN9-SST2-L-054,522
34.78Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
34.78Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
34.78Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
34.78Single8X5YAstemizole8X5Y-H1-Astemizole
34.78Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
34.78Consensuslpl_onOrthosteric Ligands1p_on lpa_on
34.78Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
34.62Single7C61Ergotamine7C61-5-HT1B-Ergotamine
34.62Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
34.62Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
34.62Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
34.48Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
34.48Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
33.33Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
33.33Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
33.33Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
33.33Single4IARErgotamine4IAR-5-HT1B-Ergotamine
33.33Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
33.33Single4RWADIPP-NH24RWA-δ-DIPP-NH2
33.33Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
33.33Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
33.33Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
33.33Single5GLHEndothelin-15GLH-ETB-Endothelin-1
33.33Single5V54Methiothepin5V54-5-HT1B-Methiothepin
33.33Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
33.33Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
33.33Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
33.33Single6AKXA4R6AKX-CCR5-A4R
33.33Single6AKYMaraviroc6AKY-CCR5-Maraviroc
33.33Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Single6H7JIsoprenaline6H7J-β1-Isoprenaline
33.33Single6IGKEndothelin-36IGK-ETB-Endothelin-3
33.33Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
33.33Single6KUXRS-799486KUX-α2a-RS-79948
33.33Single6ME2Ramelteon6ME2-MT1-Ramelteon
33.33Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
33.33Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
33.33Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
33.33Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
33.33Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
33.33Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
33.33Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
33.33Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
33.33Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
33.33Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
33.33Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
33.33Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
33.33Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
33.33Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
33.33Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
33.33Single8E0GBU728E0G-μ-BU72
33.33Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
33.33Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
33.33Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
33.33Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
33.33Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
33.33Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
33.33Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
33.33Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
33.33Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
33.33Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8IWESpermidine8IWE-TAAR9-Spermidine
33.33Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
33.33Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
33.33Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
33.33Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
33.33Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
33.33Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33Consensus5ht1_offOrthosteric Ligand5ht1b_off
33.33Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
33.33Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
33.33Consensus5ht5_offOrthosteric Ligand5ht5a_off
33.33Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
33.33Consensusalpha1_onOrthosteric Ligandalpha1a_on
33.33Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
33.33Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
33.33Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
33.33Consensuschemerin_onOrthosteric Ligandcml1_on
33.33Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
33.33Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
33.33Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
33.33Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
33.33Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
33.33Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
33.33Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
33.33Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
33.33Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
33.33Consensussst_onOrthosteric Ligandsst2_on sst4_on
32.26Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
32.26Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
32.14Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
32.14Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
32.14Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
32.14Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
32.14Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
32.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
32.00Single6HLOAprepitant6HLO-NK1-Aprepitant
32.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
32.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
32.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
32.00Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
32.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
31.82Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
31.82Single4AMIBucindolol4AMI-β1-Bucindolol
31.82Single4LDEBI1671074LDE-β2-BI167107
31.82Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
31.82Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
31.82Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
31.82Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
31.82Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
31.82Single6MXTSalmeterol6MXT-β2-Salmeterol
31.82Single6OS2TRV0266OS2-AT1-TRV026
31.82Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
31.82Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
31.82Single6ZG4HTL00099366ZG4-M1-HTL0009936
31.82Single7DFPSpiperone7DFP-D2-Spiperone
31.82Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
31.82Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
31.82Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.82Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
31.82Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
31.82Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
31.82Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
31.82Single8JJ8Formoterol8JJ8-β2-Formoterol
31.82Single8JJLOlodaterol8JJL-β2-Olodaterol
31.82Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.82Single8WU1KCA8WU1-CB1-KCA-Arrestin1
31.82Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
31.82Consensusdp_offOrthosteric Liganddp2_off
31.82Consensusgi_class-fOther Ligandgi_frizzled
31.82Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
31.82Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
31.58Single2YDOAdenosine2YDO-A2A-Adenosine
31.58Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
31.58Single4MBSMaraviroc4MBS-CCR5-Maraviroc
31.58Single4ZJCSB-6740424ZJC-OX1-SB-674042
31.58Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
31.58Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
31.58Single6TPGEMPA6TPG-OX2-EMPA
31.58Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
31.58Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
31.58Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
31.58Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
31.58Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
31.58Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
31.58Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
31.58Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.58Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
31.58Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
31.58Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
31.58Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8GGKEpinephrine8GGK-β2-Epinephrine
31.58Single8GGMEpinephrine8GGM-β2-Epinephrine
31.58Single8GGPEpinephrine8GGP-β2-Epinephrine
31.58Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
31.58Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
31.58Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
31.58Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
31.58Single8K5CAcipimox8K5C-HCA2-Acipimox
31.58Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
31.58Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
31.58Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
31.58Consensushca_onOrthosteric Ligandhca2_on hca3_on
31.58Consensushcar_onOrthosteric Ligandhca_on
31.58Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
31.58Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
31.25Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
31.25Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
31.25Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
31.03Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
31.03Consensusendothelin_onOrthosteric Ligandetb_on eta_on
31.03Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
30.77Single5WF5UK-4320975WF5-A2A-UK-432097
30.77Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
30.77Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
30.77Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
30.77Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
30.77Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
30.77Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
30.43Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
30.43Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
30.43Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
30.43Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
30.43Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
30.43Single6IBLArformoterol6IBL-β1-Arformoterol
30.43Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
30.43Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
30.43Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.43Single7UM4AS26747237UM4-5-HT5A-AS2674723
30.43Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
30.43Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
30.43Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
30.43Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
30.43Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.43Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
30.43Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
30.43Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
30.43Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
30.43Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
30.43Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
30.43Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.43Consensusorexin_onOrthosteric Ligandox2_on
30.43Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
30.30Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
30.30Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
30.30Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
30.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
30.00Single2Y01Dobutamine2Y01-β1-Dobutamine
30.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
30.00Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
30.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
30.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
30.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
30.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
30.00Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
30.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
30.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
30.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
30.00Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
30.00Single6PS1Timolol6PS1-β2-Timolol
30.00Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
30.00Single7BU7BI1671077BU7-β1-BI167107
30.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
30.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
30.00Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
30.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
30.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
30.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
30.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
30.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
30.00Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
30.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
30.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
30.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
30.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
30.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
30.00Single8CU6LJ-45178CU6-A2A-LJ-4517
30.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
30.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
30.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
30.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
30.00Single8JJOAlprenolol8JJO-β2-Alprenolol
30.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
30.00Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
30.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
30.00Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
30.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
30.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
30.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
30.00Consensusblt_onOrthosteric Ligandblt1_on
30.00Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
30.00Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
30.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
30.00Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
30.00Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
30.00Consensusleuko_onOrthosteric Ligandblt_on
29.63Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
29.63Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
29.63Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
29.63Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single3UZAGTPL92363UZA-A2A-GTPL9236
29.41Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
29.41Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
29.41Single6ME5Agomelatine6ME5-MT1-Agomelatine
29.41Single6ME9Ramelteon6ME9-MT2-Ramelteon
29.41Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
29.41Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
29.41Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
29.41Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
29.41Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Single5ZTYAM102575ZTY-CB2-AM10257
29.17Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
29.17Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
29.17Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
29.17Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.17Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
29.17Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
29.17Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
29.17Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
29.17Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
29.17Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
29.17Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
29.17Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
29.17Consensuslpl_offOrthosteric Ligands1p_off lpa_off
28.57Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
28.57Single5NM2ZM2413855NM2-A2A-ZM241385-Na
28.57Single5TVNLSD5TVN-5-HT2B-LSD
28.57Single5WQCEMPA5WQC-OX2-EMPA
28.57Single6E67BI1671076E67-β2-BI167107-Gs (fused)
28.57Single6LUQHaloperidol6LUQ-D2-Haloperidol
28.57Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
28.57Single6PS6Timolol6PS6-β2-Timolol
28.57Single6TP6Filorexant6TP6-OX1-Filorexant
28.57Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
28.57Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
28.57Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
28.57Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
28.57Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
28.57Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
28.57Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
28.57Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
28.57Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
28.57Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
28.57Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
28.57Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
28.57Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
28.57Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
28.57Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
28.57Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
28.57Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
28.57Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
28.57Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
28.57Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
28.57Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
28.57Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
28.57Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
28.57Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
28.57Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
28.12Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
28.12Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
28.00Single7F8XNN90567F8X-CCKA-NN9056
28.00Single7QA8Peptide7QA8-STE2-Peptide
28.00Single7QA8Peptide7QA8-STE2-Peptide
28.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
28.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
28.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
28.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
28.00Consensusclass-d_offOrthosteric Ligandste2_off
28.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
28.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Single3OE9IT1t3OE9-CXCR4-IT1t
27.78Single3PBLEticlopride3PBL-D3-Eticlopride
27.78Single5L7IVismodegib5L7I-SMO-Vismodegib
27.78Single6HLLCP999946HLL-NK1-CP99994
27.78Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
27.78Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
27.78Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
27.78Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
27.78Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
27.78Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
27.78Single8GH1Epinephrine8GH1-β2-Epinephrine
27.78Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
27.78Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
27.78Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
27.78Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
27.78Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
27.59Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
27.59Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
27.59Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
27.59Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
27.59Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
27.59Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
27.27Single3P0GBI1671073P0G-β2-BI167107
27.27Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
27.27Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
27.27Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
27.27Single4DJHJDTic4DJH-κ-JDTic
27.27Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
27.27Single4U15Tiotropium4U15-M3-Tiotropium
27.27Single5X93K-87945X93-ETB-K-8794
27.27Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
27.27Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
27.27Single6OL9Tiotropium6OL9-M5-Tiotropium
27.27Single6OS1TRV0266OS1-AT1-TRV026
27.27Single6TQ7SB-3348676TQ7-OX1-SB-334867
27.27Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
27.27Single6WGTLSD6WGT-5-HT2A-LSD
27.27Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
27.27Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
27.27Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
27.27Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
27.27Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
27.27Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
27.27Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
27.27Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
27.27Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
27.27Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
27.27Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
27.27Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
27.27Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
27.27Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
27.27Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
27.27Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
27.27Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
27.27Consensuscck_onOrthosteric Ligandccka_on cckb_on
27.27Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
27.27Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
27.27Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
27.27Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
27.27Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
27.27Consensushistamine_offOrthosteric Ligandh1_off
27.27Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
27.27Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
27.27Consensuslpa_offOrthosteric Ligandlpa1_off
27.27Consensuslpa_onOrthosteric Ligandlpa1_on
27.27Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
27.27Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
27.27Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
27.27Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
26.92Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
26.92Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
26.92Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
26.92Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
26.92Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
26.92Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
26.92Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
26.92Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
26.92Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
26.67Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
26.67Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
26.67Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
26.47Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
26.47Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
26.32Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
26.32Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
26.32Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
26.32Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
26.32Single3PWHZM2413853PWH-A2A-ZM241385
26.32Single5DHHSB-6121115DHH-NOP-SB-612111
26.32Single5K2DZM2413855K2D-A2A-ZM241385
26.32Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
26.32Single5WS3EMPA5WS3-OX2-EMPA
26.32Single6B73PubChem 1319551386B73-κ-PubChem 131955138
26.32Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
26.32Single6JZHZM2413856JZH-A2A-ZM241385-Na
26.32Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
26.32Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
26.32Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
26.32Single6PS7ZM2413856PS7-A2A-ZM241385-Na
26.32Single6TODEMPA6TOD-OX1-EMPA-Na
26.32Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
26.32Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
26.32Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
26.32Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
26.32Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
26.32Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
26.32Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
26.32Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
26.32Single7XRRLemborexant7XRR-OX2-Lemborexant
26.32Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
26.32Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
26.32Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
26.32Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
26.32Single8IHKAcifran8IHK-HCA3-Acifran
26.32Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
26.32Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
26.32Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
26.32Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
26.32Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
26.32Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
26.32Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
26.32Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
26.32Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Consensusgt_class-aOrthosteric Ligandgt_opsin
26.32Consensusgt_opsinOrthosteric Ligandgt_sensory
26.32Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
26.32Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
26.32Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
26.32Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
26.32Consensusmglu_onOther Ligandmglu2_on mglu4_on
26.32Consensusorexin_offOrthosteric Ligandox2_off ox1_off
26.32Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
26.09Single4N4WSANT-14N4W-SMO-SANT-1
26.09Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.09Single4PY02MeSATP4PY0-P2Y12-2MeSATP
26.09Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
26.09Single5CXVTiotropium5CXV-M1-Tiotropium
26.09Single6A93Risperidone6A93-5-HT2A-Risperidone
26.09Single6CM4Risperidone6CM4-D2-Risperidone
26.09Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
26.09Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
26.09Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
26.09Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
26.09Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
26.09Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
26.09Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
26.09Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
26.09Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
26.09Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
26.09Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
26.09Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
26.09Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
26.09Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
26.09Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
26.09Consensuschemokine_offOrthosteric Ligandcxcr_off
26.09Consensusclass-b2_onOrthosteric Ligandadgrg_on
26.09Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
26.09Consensuscxcr_offOrthosteric Ligandcxcr4_off
26.09Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
26.09Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
26.09Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
26.09Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
26.09Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
26.09Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
26.09Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
26.09Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
26.09Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.93Single3OE0CVX153OE0-CXCR4-CVX15
25.93Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
25.93Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
25.93Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
25.81Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
25.81Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
25.81Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
25.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
25.00Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
25.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
25.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
25.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
25.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
25.00Single5IU4ZM2413855IU4-A2A-ZM241385-Na
25.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
25.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
25.00Single5JTBZM2413855JTB-A2A-ZM241385
25.00Single5K2CZM2413855K2C-A2A-ZM241385-Na
25.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
25.00Single5NLXZM2413855NLX-A2A-ZM241385-Na
25.00Single5NM4ZM2413855NM4-A2A-ZM241385-Na
25.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
25.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
25.00Single6A94Zotepine6A94-5-HT2A-Zotepine
25.00Single6AQFZM2413856AQF-A2A-ZM241385
25.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
25.00Single6IQLL7458706IQL-D4-L745870
25.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
25.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
25.00Single6MH8ZM2413856MH8-A2A-ZM241385
25.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
25.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
25.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
25.00Single6V9SGTPL114036V9S-OX1-GTPL11403
25.00Single6VI4JDTic6VI4-κ-JDTic
25.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
25.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
25.00Single7AROLUF58337ARO-A2A-LUF5833-Na
25.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
25.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
25.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
25.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
25.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
25.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
25.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
25.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
25.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
25.00Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
25.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
25.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
25.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7T32ZM2413857T32-A2A-ZM241385
25.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
25.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
25.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
25.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
25.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
25.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
25.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
25.00Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GGLEpinephrine8GGL-β2-Epinephrine
25.00Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
25.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
25.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
25.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
25.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
25.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
25.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
25.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
25.00Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
25.00Single8PWNTheophylline8PWN-A2A-Theophylline
25.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
25.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
25.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
25.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
25.00Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
25.00Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
25.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
25.00Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
25.00Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
25.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
25.00Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
25.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
25.00Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
25.00Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
25.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
25.00Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
25.00Consensussensory_offOrthosteric Ligandopsin_off
24.32Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
24.24Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
24.14Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
24.14Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
24.14Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
24.14Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
24.14Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
24.14Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
24.14Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
24.14Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
24.14Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
24.14Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
24.14Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
24.00Single5EE7MK08935EE7-Glucagon-MK0893
24.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
24.00Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
24.00Consensusclass-d_offOrthosteric Ligandste2_off
24.00Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
24.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
24.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
24.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
23.81Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
23.81Single2Y02Carmoterol2Y02-β1-Carmoterol
23.81Single3EMLZM2413853EML-A2A-ZM241385
23.81Single4EIYZM2413854EIY-A2A-ZM241385-Na
23.81Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
23.81Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
23.81Single4YAYZD-71554YAY-AT1-ZD-7155
23.81Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
23.81Single5DSGTiotropium5DSG-M4-Tiotropium
23.81Single5IU8Q274563475IU8-A2A-Q27456347-Na
23.81Single5K2AZM2413855K2A-A2A-ZM241385-Na
23.81Single5OLGZM2413855OLG-A2A-ZM241385-Na
23.81Single5UENDU1725UEN-A1-DU172
23.81Single5VRAZM2413855VRA-A2A-ZM241385-Na
23.81Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
23.81Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
23.81Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
23.81Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
23.81Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
23.81Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
23.81Single6LPJZM2413856LPJ-A2A-ZM241385-Na
23.81Single6LPKZM2413856LPK-A2A-ZM241385-Na
23.81Single6S0LZM2413856S0L-A2A-ZM241385
23.81Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
23.81Single7PYRPSB-21157PYR-A2A-PSB-2115
23.81Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
23.81Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
23.81Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
23.81Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
23.81Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
23.81Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
23.81Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
23.81Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
23.81Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
23.81Single8X64Desloratadine8X64-H1-Desloratadine
23.81Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
23.81Consensusa2_offOrthosteric Liganda2a_off
23.81Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
23.81Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
23.81Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
23.81Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
23.81Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
23.81Consensushistamine_onOrthosteric Ligandh1_on h4_on
23.81Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
23.81Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
23.81Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
23.81Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
23.81Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
23.53Single3RFMCaffeine3RFM-A2A-Caffeine
23.53Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
23.53Single6TQ9SB-4081246TQ9-OX1-SB-408124
23.53Single8A2OTheophylline8A2O-A2A-Theophylline-Na
23.53Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
23.53Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
23.53Consensussensory_onOrthosteric Ligandopsin_on
23.33Single4XT3Fractalkine4XT3-US28-Fractalkine
23.33Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
23.33Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
23.33Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
23.33Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
23.33Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Consensusclass-d_onOrthosteric Ligandste2_on
23.33Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
23.33Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
23.08Single4XT1Fractalkine4XT1-US28-Fractalkine
23.08Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
23.08Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
23.08Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
23.08Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
22.86Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
22.73Single4NTJAZD12834NTJ-P2Y12-AZD1283
22.73Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
22.73Single5IUAQ274563485IUA-A2A-Q27456348-Na
22.73Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
22.73Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
22.73Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
22.73Single6LPLZM2413856LPL-A2A-ZM241385-Na
22.73Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
22.73Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
22.73Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
22.73Single6S0QZM2413856S0Q-A2A-ZM241385
22.73Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
22.73Single6WQAZM2413856WQA-A2A-ZM241385-Na
22.73Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
22.73Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
22.73Single7RM5ZM2413857RM5-A2A-ZM241385-Na
22.73Single7SINNPS-21437SIN-CaS-NPS-2143
22.73Single7SINNPS-21437SIN-CaS-NPS-2143
22.73Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
22.73Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
22.73Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
22.73Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
22.73Single8EA0Iperoxo8EA0-M3-Iperoxo
22.73Single8FYNZM2413858FYN-A2A-ZM241385-Na
22.73Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
22.73Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
22.73Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
22.73Single8QOTNanobody E8QOT-μ-Nanobody E
22.73Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
22.73Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.58Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
22.58Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.58Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
22.58Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
22.58Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
22.58Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
22.58Consensusgi_class-dOrthosteric Ligandgi_ste
22.58Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.58Consensusgo_class-b1Orthosteric Ligandgo_crf
22.58Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
22.58Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.22Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
22.22Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
22.22Single3OE6IT1t3OE6-CXCR4-IT1t
22.22Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
22.22Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
22.22Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
22.22Single7SK5CXCL127SK5-ACKR3-CXCL12
22.22Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.22Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
22.22Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
22.22Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
22.22Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
22.22Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
22.22Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
22.22Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
22.22Consensuspth_onOrthosteric Ligandpth1_on pth2_on
22.22Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
22.22Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
21.88Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
21.88Single6LMLGlucagon6LML-Glucagon-Glucagon
21.88Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
21.88Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
21.88Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
21.88Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
21.88Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
21.74Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
21.74Single5XR8AM8415XR8-CB1-AM841
21.74Single6J20Aprepitant6J20-NK1-Aprepitant
21.74Single7B6WCyclazosin7B6W-α1b-Cyclazosin
21.74Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
21.74Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
21.74Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
21.74Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
21.74Single7PX4PSB-21137PX4-A2A-PSB-2113
21.74Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
21.74Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
21.74Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
21.74Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
21.74Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
21.74Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
21.74Consensusadenosine_offOrthosteric Liganda1_off a2_off
21.74Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
21.74Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
21.74Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
21.74Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
21.74Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
21.74Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
21.43Single6W25SHU91196W25-MC4-SHU9119-Ca
21.43Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
21.21Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
21.21Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
21.21Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
21.05Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
21.05Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
21.05Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
21.05Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
21.05Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
21.05Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
21.05Single4O9RCyclopamine4O9R-SMO-Cyclopamine
21.05Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
21.05Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
21.05Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
21.05Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
21.05Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
21.05Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
21.05Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
21.05Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
21.05Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
21.05Single7SRQLSD7SRQ-5-HT2B-LSD
21.05Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
21.05Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
21.05Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
21.05Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
21.05Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
21.05Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
21.05Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
21.05Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
21.05Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
21.05Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
21.05Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
21.05Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
21.05Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
20.83Single6HLPNetupitant6HLP-NK1-Netupitant
20.83Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
20.83Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
20.83Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.83Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
20.83Single7K15MKD0467K15-BLT1-MKD046-Na
20.83Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
20.83Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
20.83Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
20.83Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
20.83Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
20.83Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
20.83Consensusblt_offOrthosteric Ligandblt1_off
20.83Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
20.83Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
20.69Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
20.69Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
20.69Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
20.69Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
20.69Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
20.69Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.59Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
20.59Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
20.59Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
20.59Consensusglp_onOrthosteric Ligandglp1_on glp2_on
20.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
20.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
20.00Single3ODUIT1t3ODU-CXCR4-IT1t
20.00Single4QINSAG1.54QIN-SMO-SAG1.5
20.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
20.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
20.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
20.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
20.00Single6K1QIRL25006K1Q-ETB-IRL2500
20.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
20.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
20.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
20.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
20.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
20.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
20.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
20.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
20.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
20.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
20.00Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
20.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
20.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
20.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
20.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
20.00Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
20.00Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
20.00Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
20.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
20.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
20.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
20.00Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
20.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
20.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
20.00Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
20.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusclass-f_offOrthosteric Ligandsmo_off
20.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
20.00Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
20.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
20.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
20.00Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.00Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
19.51Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
19.51Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
19.44Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
19.44Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
19.44Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
19.44Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
19.35Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
19.35Single7SK3CXCL127SK3-ACKR3-CXCL12
19.35Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
19.35Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
19.23Single6KNMJN241-96KNM-Apelin-JN241-9
19.23Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
19.23Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
19.23Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
19.23Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
19.23Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
19.23Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
19.23Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Consensusgs_class-b2Orthosteric Ligandgs_adgr
19.23Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
19.05Single3REYPubChem 56973REY-A2A-PubChem 5697
19.05Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
19.05Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
19.05Single5K2BZM2413855K2B-A2A-ZM241385-Na
19.05Single5UVIZM2413855UVI-A2A-ZM241385
19.05Single6DS0Ly2660976DS0-5-HT2B-Ly266097
19.05Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
19.05Single6TP3Nemorexant6TP3-OX1-Nemorexant
19.05Single6TPNHTL66416TPN-OX2-HTL6641
19.05Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
19.05Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
19.05Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
19.05Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
19.05Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
19.05Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
19.05Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
19.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
19.05Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
19.05Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
19.05Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
19.05Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
19.05Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
19.05Consensuss1p_offOrthosteric Ligands1p1_off
18.92Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
18.92Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
18.75Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
18.75Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
18.75Single5MZPCaffeine5MZP-A2A-Caffeine-Na
18.75Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
18.75Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.75Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
18.75Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
18.75Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
18.75Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
18.75Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
18.75Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
18.75Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
18.52Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.52Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
18.52Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
18.52Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
18.52Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
18.42Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
18.18Single4DAJTiotropium4DAJ-M3-Tiotropium
18.18Single4MQSIperoxo4MQS-M2-Iperoxo
18.18Single4U14Tiotropium4U14-M3-Tiotropium
18.18Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
18.18Single5TGZAM65385TGZ-CB1-AM6538
18.18Single6D27CAY104716D27-DP2-CAY10471
18.18Single6DRXLisuride6DRX-5-HT2B-Lisuride
18.18Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
18.18Single6GPSMK08126GPS-CCR2-MK0812
18.18Single6IIVDaltroban6IIV-TP-Daltroban
18.18Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
18.18Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
18.18Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
18.18Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
18.18Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
18.18Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
18.18Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
18.18Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
18.18Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.18Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.18Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
18.18Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
18.18Single8X63Mepyramine8X63-H1-Mepyramine
18.18Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
18.18Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
18.18Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
18.18Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
18.18Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
18.18Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
18.18Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
18.18Consensustachykinin_offOrthosteric Ligandnk1_off
18.18Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
18.18Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
17.95Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
17.86Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
17.86Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
17.86Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
17.65Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
17.65Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
17.65Consensusclass-c_onOther Ligandgabab_on mglu_on
17.65Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
17.65Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
17.65Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
17.50Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
17.50Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
17.39Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
17.39Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
17.39Single5CGCHTL142425CGC-mGlu5-HTL14242
17.39Single5XPRBosentan5XPR-ETB-Bosentan
17.39Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
17.39Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
17.39Single6GPXMK08126GPX-CCR2-MK0812
17.39Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
17.39Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
17.39Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
17.39Single7C4SS1P7C4S-S1P3-S1P
17.39Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
17.39Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
17.39Single7YXAONO-54306087YXA-S1P5-ONO-5430608
17.39Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
17.39Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
17.39Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
17.39Consensusep_offOrthosteric Ligandep4_off
17.24Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.24Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.14Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
16.67Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
16.67Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
16.67Single5TZR-5TZR-FFA1 (GPR40)-MK8666
16.67Single5V56TC1145V56-SMO-TC114
16.67Single5V57TC1145V57-SMO-TC114
16.67Single5XRAAM115425XRA-CB1-AM11542
16.67Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
16.67Single6E59L-7607356E59-NK1-L-760735
16.67Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
16.67Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.67Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Single7EPENAM5637EPE-mGlu-NAM563
16.67Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
16.67Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
16.67Single7W41PD1762527W41-BB2-PD176252
16.67Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
16.67Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
16.67Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
16.67Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
16.67Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
16.67Consensusbombesin_offOrthosteric Ligandbb2_off
16.67Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
16.67Consensusclass-d_onOrthosteric Ligandste2_on
16.67Consensusgi_class-dOrthosteric Ligandgi_ste
16.67Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
16.67Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
16.67Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
16.67Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
16.67Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.22Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
16.13Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
16.00Single4XESNeurotensin4XES-NTS1-Neurotensin
16.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
16.00Single6IIURamatroban6IIU-TP-Ramatroban
16.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
16.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
16.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
16.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
16.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
16.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
16.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
16.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
16.00Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
16.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
16.00Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
16.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
16.00Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
16.00Consensusnts_onOrthosteric Ligandnts1_on
16.00Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
15.79Single3OE8IT1t3OE8-CXCR4-IT1t
15.79Single4XNWMRS25004XNW-P2Y1-MRS2500
15.79Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
15.79Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
15.79Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
15.79Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
15.62Single6FJ3PTH6FJ3-PTH1-PTH
15.62Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.62Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
15.38Single4BUONeurotensin4BUO-NTS1-Neurotensin
15.38Single5CGDHTL142425CGD-mGlu5-HTL14242
15.38Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
15.38Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
15.38Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
15.38Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
15.38Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
15.38Consensuscyslt_offOrthosteric Ligandcyslt2_off
15.38Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
15.38Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.15Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
15.15Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
15.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
15.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
15.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
15.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
15.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
15.00Consensusclass-t_onOrthosteric Ligandtaste2_on
15.00Consensusgs_class-tOrthosteric Ligandgs_taste
15.00Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.00Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
15.00Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
14.81Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
14.81Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
14.81Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.71Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.71Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
14.29Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
14.29Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
14.29Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
14.29Single7BR3Elagolix7BR3-GnRH1-Elagolix
14.29Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
14.29Single7F8ULintitript7F8U-CCKA-Lintitript
14.29Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
14.29Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
14.29Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
14.29Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
14.29Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
14.29Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
14.29Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
14.29Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
14.29Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
14.29Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
14.29Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
13.79Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
13.79Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
13.79Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
13.64Single3RZECidoxepin3RZE-H1-Cidoxepin
13.64Single6FFIMMPEP6FFI-mGlu5-MMPEP
13.64Single6TPKRetosiban6TPK-OT-Retosiban
13.64Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
13.64Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
13.64Single7VODCariprazine7VOD-5-HT2A-Cariprazine
13.64Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
13.64Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
13.64Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
13.64Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single8K2WAMG4878K2W-CXCR3-AMG487
13.64Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
13.64Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
13.64Consensusgi_class-fOrthosteric Ligandgi_frizzled
13.64Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
13.64Consensusgnrh_offOrthosteric Ligandgnrh1_off
13.64Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
13.64Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
13.64Consensusvasopressin-ot_offOrthosteric Ligandot_off
13.51Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
13.33Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
13.33Single7XNACYN1548067XNA-SST2-CYN154806
13.33Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
13.33Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
13.33Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
13.04Single5T04Neurotensin5T04-NTS1-Neurotensin
13.04Single6FFHFenobam6FFH-mGlu5-Fenobam
13.04Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
13.04Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
13.04Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
13.04Single7F83PF-051904577F83-Ghrelin-PF-05190457
13.04Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
13.04Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
13.04Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.04Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
13.04Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
13.04Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
13.04Consensuscck_offOrthosteric Ligandccka_off
13.04Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
13.04Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Consensushcar_offOrthosteric Ligandsuccinate_off
13.04Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
13.04Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
12.90Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
12.90Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
12.50Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
12.50Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
12.50Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
12.50Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
12.50Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
12.50Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
12.50Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.50Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
12.50Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
12.12Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
12.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
12.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
12.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
12.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
12.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
12.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
12.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
12.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
12.00Single7P2L4YI7P2L-mGlu5-4YI
12.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
12.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
12.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
12.00Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
12.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
11.76Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
11.54Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
11.54Single5X33BIIL2605X33-BLT1-BIIL260
11.54Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
11.54Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
11.54Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
11.54Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
11.54Consensusnts_offOrthosteric Ligandnts1_off
11.43Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
11.43Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
11.43Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
11.11Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
11.11Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single7WC4Serotonin7WC4-5-HT2A-Serotonin
11.11Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
10.71Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
10.71Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.71Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
10.53Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.53Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
10.34Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
10.34Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
10.34Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
10.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
10.00Single6LI0GTPL98046LI0-GPR52-GTPL9804
10.00Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
10.00Single7SHEPI; PE7SHE-GPR158-PI; PE
10.00Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
10.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
10.00Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensussst_offOrthosteric Ligandsst2_off
9.68Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.68Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
9.52Single6TP4ACT-4622066TP4-OX1-ACT-462206
9.52Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single7UL2SR486927UL2-NTS1-SR48692-Na
9.52Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
9.52Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
9.52Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
9.09Single4BWBNeurotensin4BWB-NTS1-Neurotensin
9.09Single5U09Taranabant5U09-CB1-Taranabant
9.09Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
9.09Single7F8YDevazepide7F8Y-CCKA-Devazepide
9.09Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
9.09Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
9.09Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
9.09Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
9.09Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
9.09Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
8.82Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
8.70Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
8.70Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
8.70Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single7VV6C48/807VV6-MRGPRX2-C48/80
8.70Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
8.70Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
8.33Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
8.11Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
8.11Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
8.00Single6Z4SSR486926Z4S-NTS1-SR48692
8.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
8.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
7.50Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
7.50Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
7.41Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
7.14Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
6.82Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
6.67Consensusclass-c_offOther Ligandgabab_off mglu_off
6.45Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
6.45Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Single8HS2Fab0468HS2-GPR20-Fab046
5.56Single6W25Ca6W25-MC4-SHU9119-Ca
5.56Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.56Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
5.26Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
5.26Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.26Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
5.26Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.13Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.00Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
5.00Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
5.00Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.00Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
4.76Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
4.76Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
4.65Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.55Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
4.55Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
4.55Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
4.55Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
4.55Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
4.55Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.55Consensusgo_class-b2Orthosteric Ligandgo_adhesion
4.55Consensusgo_proteinOrthosteric Ligandgo_chemokine
4.55Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
4.35Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.35Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
4.35Single8HNNSCH5467388HNN-CXCR3-SCH546738
4.35Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
4.35Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
4.35Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.17Single6ZINSR486926ZIN-NTS1-SR48692
4.17Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
4.17Single8IYXYL-3658IYX-GPR34-YL-365
3.57Single7SHEPI; PE7SHE-GPR158-PI; PE
3.57Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
3.45Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.56Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.56Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2

Consensus Members
Id Members
bileacid_on 7CFN-GPBA-INT-777-Gs/&β;1/&γ;2
7CFM-GPBA-P395-Gs/&β;1/&γ;2
7XTQ-GPBA-R399-Gs/&β;1/&γ;2
Net Summary
Imin 2.55333
Number of Linked Nodes 234
Number of Links 281
Number of Hubs 37
Number of Links mediated by Hubs 158
Number of Communities 9
Number of Nodes involved in Communities 60
Number of Links involved in Communities 89
Path Summary
Number Of Nodes in MetaPath 79
Number Of Links MetaPath 78
Number of Shortest Paths 45152
Length Of Smallest Path 3
Average Path Length 12.1538
Length of Longest Path 27
Minimum Path Strength 0.661111
Average Path Strength 4.68111
Maximum Path Strength 18.9583
Minimum Path Correlation 0.7
Average Path Correlation 0.931823
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.54545
Average % Of Corr. Nodes 55.1567
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.755
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
class-a_onsensory_on
amine_on
lipid_on
nucleotide_on
peptide_on
protein_on
hcar_on
steroid_on
melatonin_on



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download steroid_on.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.