Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x35 6.4825403
21x42 5.4075417
31x45 3.255405
41x52 4.7825428
51x53 2.545409
61x56 5.04428
71x57 5.285428
81x60 9.19426
92x36 8.165426
102x40 7.7528
112x50 10.0583619
122x61 6.045414
13E1.N72 4.2275403
14E1.N76 6.0475403
153x32 11.718514
163x36 6.99518
173x40 6.935416
183x41 8.88286717
193x42 4.616537
203x45 4.595435
213x52 3.5575407
224x44 3.935437
234x58 4.4125406
24E2.Q151 5.8403
255x47 5.434515
265x48 3.0625403
275x51 7.53417
285x54 4.63518
295x58 7.59407
30I3.G215 2.1575405
316x31 4.07466
326x34 6.425469
336x38 3.2975407
346x51 7.458517
357x38 3.82403
367x43 7.9775414
377x45 10.354516
387x46 5.4575418
397x47 3.99418
407x49 7.68333619
417x52 5.034518
427x55 6.2675415
438x49 8.916528
448x50 8.0775429
45Lig 9.70875810
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
11x40 1x41 10.67831.6NoNo055
21x39 1x40 15.87681.54NoNo045
31x35 2x61 15.61335.01YesYes034
42x61 7x43 20.4138.02YesYes144
51x42 7x43 26.32729.08YesYes174
61x42 7x47 13.23843.2YesYes178
72x57 7x43 66.38778.53NoYes144
82x57 3x32 50.92043.42NoYes144
93x32 3x36 10010.17YesYes148
102x53 3x36 43.16546.87NoYes048
112x53 7x46 44.46866.57NoYes048
122x50 7x46 28.20012.88YesYes198
131x50 2x50 24.01287.23NoYes099
141x50 2x51 20.39172.96NoNo096
152x51 2x55 17.9422.45NoNo061
161x43 2x55 15.42116.04NoNo451
173x36 3x40 32.63669.54YesYes186
183x39 3x40 36.49632.98NoYes086
192x50 3x39 36.93799.22YesNo098
201x43 2x58 14.2145.24NoNo054
212x50 7x49 46.950312.41YesYes199
227x49 7x53 67.42039YesNo099
231x53 7x53 65.81452.85YesNo099
241x53 8x50 59.30924.28YesYes099
251x56 8x50 29.90562.98YesYes289
261x52 1x56 23.55357.87YesYes288
277x45 7x46 18.29454.17YesYes168
287x45 7x49 64.881610.89YesYes169
293x36 5x47 28.73426.81YesYes185
305x47 6x51 69.5143.49YesYes157
316x51 7x45 46.17069.93YesYes176
322x57 Lig 17.78892.88NoYes140
335x43 Lig 45.75753.07NoYes020
345x43 5x47 47.20672.92NoYes025
351x52 8x57 12.8613.93YesNo086
368x49 8x50 26.476812.69YesYes289
372x40 8x49 10.61064.15YesYes288
381x60 8x49 10.78876.75YesYes268
392x46 2x50 20.099712.15NoYes099
402x46 3x42 17.98476.92NoYes097
415x51 6x51 28.178710.32YesYes177
425x51 5x54 36.33613.89YesYes178
435x54 5x57 17.11233.2YesNo188
443x48 5x57 21.84443.1NoNo068
453x48 3x52 20.76552.85NoYes067
462x58 2x62 12.95715.05NoNo044
472x62 2x66 11.69315.86NoNo044
482x66 E1.N72 10.42191.37NoYes043
493x29 3x32 43.46092.89NoYes124
503x29 5x42 57.42925.05NoNo024
514x58 5x42 55.05072.77YesNo064
524x58 4x62 37.31896.63YesNo064
534x62 E2.Q151 34.69825.49NoYes043
543x26 E2.Q151 18.82149.61NoYes023
553x22 3x26 13.48762.94NoNo042
563x29 Lig 16.30414.88NoYes120
573x40 5x50 14.74459.77YesNo168
583x41 5x50 12.159514.86YesNo178
596x44 7x49 47.88683.39NoYes199
605x58 6x44 48.78057.5YesNo079
613x47 5x54 20.30276.4NoYes188
623x47 5x58 25.757514.53NoYes087
633x52 4x43 10.06944.47YesNo076
645x58 6x41 62.73465.24YesNo077
654x58 5x41 13.29185.48YesNo063
664x63 E2.Q151 10.80651.32NoYes033
675x40 5x41 10.61421.57NoNo033
685x62 6x41 56.88094.61NoNo077
695x62 6x38 50.75664.28NoYes077
705x69 6x38 44.57181.38NoYes067
715x69 6x34 38.54376.43NoYes069
726x31 6x34 19.46953.94YesYes669
736x31 I3.G215 15.37483.49YesYes065
746x30 6x34 10.82076.97NoYes689
757x49 7x52 10.98813.98YesYes198
766x58 Lig 12.08473.12NoYes050
776x58 7x38 10.6323.44NoYes053
781x39 7x43 18.09516.28NoYes144
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x327.360NoYes4421
2x573x323.421NoYes4411
2x577x438.531NoYes4412
2x57Lig2.881NoYes4010
2x602x644.390NoNo4412
2x60Lig18.090NoYes4010
3x293x322.891NoYes2411
3x295x425.051NoNo2412
3x29Lig4.881NoYes2010
3x323x3610.171YesYes4812
3x32Lig34.751YesYes4010
3x365x476.811YesYes8522
5x39E3.F2523.620NoNo3221
5x435x472.920NoYes2512
5x43Lig3.070NoYes2010
6x587x383.440NoYes5312
6x58Lig3.120NoYes5010
7x357x3911.660NoNo1321
7x39Lig9.190NoYes3010
E3.F252Lig1.690NoYes2010
5x436x591.590NoNo2312

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
100.00Consensusclass-t_onOrthosteric Ligandtaste2_on
100.00Consensusgs_class-tOrthosteric Ligandgs_taste
100.00Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
41.67Single7F8YDevazepide7F8Y-CCKA-Devazepide
35.71Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
35.71Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
35.71Consensuscck_offOrthosteric Ligandccka_off
35.71Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
33.33Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
33.33Single7YXAONO-54306087YXA-S1P5-ONO-5430608
33.33Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
33.33Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
33.33Consensusclass-d_offOrthosteric Ligandste2_off
33.33Consensusclass-d_onOrthosteric Ligandste2_on
33.33Consensusgi_class-dOrthosteric Ligandgi_ste
33.33Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
31.82Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
31.58Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
31.58Single7QA8Peptide7QA8-STE2-Peptide
31.58Single7QA8Peptide7QA8-STE2-Peptide
31.58Consensusclass-d_offOrthosteric Ligandste2_off
31.25Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
31.25Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single5WS3EMPA5WS3-OX2-EMPA
30.77Single6B73PubChem 1319551386B73-κ-PubChem 131955138
30.77Single7XRRLemborexant7XRR-OX2-Lemborexant
30.77Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
30.77Consensusorexin_offOrthosteric Ligandox2_off ox1_off
30.43Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
30.43Consensusclass-d_onOrthosteric Ligandste2_on
30.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
29.41Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
29.41Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
29.41Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
29.41Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
29.17Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
29.17Consensusgi_class-dOrthosteric Ligandgi_ste
29.17Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
28.57Single4ZJCSB-6740424ZJC-OX1-SB-674042
28.57Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
28.57Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
28.57Single6TPGEMPA6TPG-OX2-EMPA
28.57Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
28.57Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
28.57Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
28.57Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
28.57Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
28.57Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
28.57Consensusgnrh_offOrthosteric Ligandgnrh1_off
28.57Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
28.57Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
28.57Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
27.78Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
27.78Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
27.78Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
27.78Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
27.78Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
27.78Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.78Consensusorexin_onOrthosteric Ligandox2_on
27.78Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
27.27Single6TQ9SB-4081246TQ9-OX1-SB-408124
27.27Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
26.67Single5TGZAM65385TGZ-CB1-AM6538
26.67Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
26.67Single6TOTLemborexant6TOT-OX1-Lemborexant
26.67Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
26.67Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
26.67Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
26.67Single7UL4Alvimopan7UL4-μ-Alvimopan
26.67Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
26.67Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
26.67Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
26.67Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
26.67Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
26.32Single5ZTYAM102575ZTY-CB2-AM10257
26.32Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
26.32Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
26.32Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
26.32Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
26.32Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
26.09Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single3OE6IT1t3OE6-CXCR4-IT1t
25.00Single3OE8IT1t3OE8-CXCR4-IT1t
25.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
25.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
25.00Single5WQCEMPA5WQC-OX2-EMPA
25.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
25.00Single6GPXMK08126GPX-CCR2-MK0812
25.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
25.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
25.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
25.00Single6TP6Filorexant6TP6-OX1-Filorexant
25.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
25.00Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
25.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
25.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
25.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
25.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
25.00Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
25.00Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
25.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
25.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
25.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
25.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
25.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
25.00Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
25.00Consensussst_onOrthosteric Ligandsst2_on sst4_on
25.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
24.14Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
24.00Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
24.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
23.81Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
23.81Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
23.81Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
23.81Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
23.81Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
23.81Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
23.81Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
23.53Single4DJHJDTic4DJH-κ-JDTic
23.53Single4RWADIPP-NH24RWA-δ-DIPP-NH2
23.53Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
23.53Single5X93K-87945X93-ETB-K-8794
23.53Single5XR8AM8415XR8-CB1-AM841
23.53Single5XRAAM115425XRA-CB1-AM11542
23.53Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
23.53Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
23.53Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
23.53Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
23.53Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8E0GBU728E0G-μ-BU72
23.53Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
23.53Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
23.53Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
23.53Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
23.53Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
23.53Consensuscck_onOrthosteric Ligandccka_on cckb_on
23.53Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
23.53Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
23.53Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
23.53Consensusrelaxin_onOrthosteric Ligandrxfp4_on
23.53Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
23.53Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
23.08Single3OE9IT1t3OE9-CXCR4-IT1t
23.08Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
23.08Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
23.08Single5L7IVismodegib5L7I-SMO-Vismodegib
23.08Single6IGLIRL16206IGL-ETB-IRL1620
23.08Single6TP4ACT-4622066TP4-OX1-ACT-462206
23.08Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
23.08Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
23.08Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
23.08Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
23.08Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
23.08Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
23.08Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
23.08Consensusgo_class-b2Orthosteric Ligandgo_adhesion
23.08Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
23.08Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
23.08Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
22.73Single6PT2KGCHM076PT2-δ-KGCHM07
22.73Single6W25SHU91196W25-MC4-SHU9119-Ca
22.73Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
22.73Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
22.73Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
22.22Single5GLHEndothelin-15GLH-ETB-Endothelin-1
22.22Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
22.22Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
22.22Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
22.22Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
22.22Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
22.22Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
22.22Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
22.22Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
22.22Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
22.22Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
22.22Single7YITNalfurafine7YIT-κ-Nalfurafine
22.22Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
22.22Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
22.22Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
22.22Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single8WU1KCA8WU1-CB1-KCA-Arrestin1
22.22Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
22.22Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
22.22Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
22.22Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
22.22Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
22.22Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
22.22Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
22.22Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
22.22Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
21.74Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
21.74Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
21.43Single3ODUIT1t3ODU-CXCR4-IT1t
21.43Single4S0VSuvorexant4S0V-OX2-Suvorexant
21.43Single5U09Taranabant5U09-CB1-Taranabant
21.43Single6AKXA4R6AKX-CCR5-A4R
21.43Single6AKYMaraviroc6AKY-CCR5-Maraviroc
21.43Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
21.43Single6TODEMPA6TOD-OX1-EMPA-Na
21.43Single6TPJSuvorexant6TPJ-OX2-Suvorexant
21.43Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
21.43Single7BR3Elagolix7BR3-GnRH1-Elagolix
21.43Single7F8ULintitript7F8U-CCKA-Lintitript
21.43Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
21.43Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.43Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
21.43Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
21.43Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
21.43Single8IHKAcifran8IHK-HCA3-Acifran
21.43Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
21.43Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
21.43Consensusclass-f_offOrthosteric Ligandsmo_off
21.43Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
21.43Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
21.05Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
21.05Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
21.05Single6K1QIRL25006K1Q-ETB-IRL2500
21.05Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
21.05Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
21.05Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
21.05Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
21.05Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
21.05Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
21.05Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
21.05Consensusendothelin_offOrthosteric Ligandetb_off
21.05Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
21.05Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
21.05Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
21.05Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
21.05Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
21.05Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
20.83Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.83Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.83Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
20.83Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
20.69Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
20.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
20.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
20.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
20.00Single6IQLL7458706IQL-D4-L745870
20.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
20.00Single6TPNHTL66416TPN-OX2-HTL6641
20.00Single6V9SGTPL114036V9S-OX1-GTPL11403
20.00Single6W25Ca6W25-MC4-SHU9119-Ca
20.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
20.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
20.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
20.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
20.00Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
20.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
20.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7SK3CXCL127SK3-ACKR3-CXCL12
20.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
20.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
20.00Single7XN9L-054,5227XN9-SST2-L-054,522
20.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
20.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
20.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
20.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
20.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
20.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
20.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
20.00Single8K2WAMG4878K2W-CXCR3-AMG487
20.00Single8K5CAcipimox8K5C-HCA2-Acipimox
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
20.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
20.00Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
20.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
20.00Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
20.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
20.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
20.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
20.00Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
20.00Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
20.00Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
20.00Consensushca_onOrthosteric Ligandhca2_on hca3_on
20.00Consensushcar_onOrthosteric Ligandhca_on
20.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
20.00Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
20.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
20.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
20.00Consensuss1p_offOrthosteric Ligands1p1_off
20.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
19.35Consensuspth_onOrthosteric Ligandpth1_on pth2_on
19.23Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
19.23Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
19.23Consensusendothelin_onOrthosteric Ligandetb_on eta_on
19.23Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
19.23Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
19.05Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
19.05Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
19.05Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
19.05Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
19.05Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
19.05Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
19.05Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
19.05Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
19.05Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
19.05Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
19.05Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
19.05Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
19.05Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
19.05Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
19.05Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
19.05Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
18.75Single2Y01Dobutamine2Y01-β1-Dobutamine
18.75Single2Y04Salbutamol2Y04-β1-Salbutamol
18.75Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
18.75Single4EJ4Naltrindole4EJ4-δ-Naltrindole
18.75Single4YAYZD-71554YAY-AT1-ZD-7155
18.75Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
18.75Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
18.75Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
18.75Single5T04Neurotensin5T04-NTS1-Neurotensin
18.75Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
18.75Single6GPSMK08126GPS-CCR2-MK0812
18.75Single6IIVDaltroban6IIV-TP-Daltroban
18.75Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
18.75Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
18.75Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
18.75Single7F83PF-051904577F83-Ghrelin-PF-05190457
18.75Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
18.75Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
18.75Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
18.75Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
18.75Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
18.75Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
18.75Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
18.75Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
18.75Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
18.75Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
18.75Single8K5DGSK2560738K5D-HCA2-GSK256073
18.75Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
18.75Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
18.75Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
18.75Consensusgi_hcarOrthosteric Ligandgi_hca
18.75Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
18.75Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
18.75Consensushcar_offOrthosteric Ligandsuccinate_off
18.75Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
18.75Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
18.75Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
18.52Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
18.52Single8IY6Endothelin-18IY6-ETB-Endothelin-1
18.52Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
18.52Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
18.52Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
18.18Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
18.18Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
18.18Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
18.18Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
18.18Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
18.18Single7SK5CXCL127SK5-ACKR3-CXCL12
18.18Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
18.18Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
18.18Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
18.18Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
18.18Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
18.18Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
18.18Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
18.18Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
18.18Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
17.86Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
17.86Single6IGKEndothelin-36IGK-ETB-Endothelin-3
17.65Single2Y00Dobutamine2Y00-β1-Dobutamine
17.65Single2Y03Isoprenaline2Y03-β1-Isoprenaline
17.65Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
17.65Single5C1MBU725C1M-μ-BU72
17.65Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
17.65Single5N2SPSB365N2S-A1-PSB36
17.65Single5WIUNemonapride5WIU-D4-Nemonapride
17.65Single5WIVNemonapride5WIV-D4-Nemonapride-Na
17.65Single5XPRBosentan5XPR-ETB-Bosentan
17.65Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
17.65Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
17.65Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
17.65Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
17.65Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
17.65Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
17.65Single7C4SS1P7C4S-S1P3-S1P
17.65Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
17.65Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
17.65Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
17.65Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
17.65Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
17.65Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
17.65Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
17.65Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
17.65Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
17.65Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
17.65Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
17.65Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
17.65Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
17.65Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
17.65Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
17.65Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
17.65Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
17.65Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
17.65Single8QOTNanobody E8QOT-μ-Nanobody E
17.65Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
17.65Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
17.65Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
17.65Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
17.65Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
17.65Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
17.65Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
17.65Consensusep_offOrthosteric Ligandep4_off
17.65Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
17.39Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
17.39Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
17.39Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
17.39Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
17.39Consensusangiotensin_onOrthosteric Ligandat1_on
17.39Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
17.39Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
17.39Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
17.39Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
17.39Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
17.39Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
17.39Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
17.24Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
17.24Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.67Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
16.67Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
16.67Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
16.67Single4BV0Neurotensin4BV0-NTS1-Neurotensin
16.67Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
16.67Single5V56TC1145V56-SMO-TC114
16.67Single5V57TC1145V57-SMO-TC114
16.67Single6H7JIsoprenaline6H7J-β1-Isoprenaline
16.67Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
16.67Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
16.67Single6TQ7SB-3348676TQ7-OX1-SB-334867
16.67Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
16.67Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
16.67Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
16.67Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
16.67Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
16.67Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
16.67Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
16.67Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
16.67Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
16.67Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
16.67Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
16.67Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
16.67Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
16.67Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
16.67Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
16.67Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
16.67Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
16.67Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
16.67Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
16.67Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
16.67Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
16.67Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
16.67Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
16.67Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
16.67Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
16.67Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
16.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
16.67Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
16.67Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
16.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
16.67Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
16.67Consensuschemerin_onOrthosteric Ligandcml1_on
16.67Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
16.67Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
16.67Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
16.67Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
16.67Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
16.67Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
16.67Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
16.67Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
16.67Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
16.67Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
16.67Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
16.67Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
16.67Consensussensory_onOrthosteric Ligandopsin_on
16.67Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
16.13Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
16.13Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
16.13Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
16.13Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
16.13Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
16.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
16.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
16.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
16.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
16.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
16.00Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
15.79Single4LDEBI1671074LDE-β2-BI167107
15.79Single4PY02MeSATP4PY0-P2Y12-2MeSATP
15.79Single4XEENeurotensin4XEE-NTS1-Neurotensin
15.79Single4XESNeurotensin4XES-NTS1-Neurotensin
15.79Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
15.79Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
15.79Single5X33BIIL2605X33-BLT1-BIIL260
15.79Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
15.79Single6HLPNetupitant6HLP-NK1-Netupitant
15.79Single6IIURamatroban6IIU-TP-Ramatroban
15.79Single6MXTSalmeterol6MXT-β2-Salmeterol
15.79Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
15.79Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
15.79Single6YVRNTS8-136YVR-NTS1-NTS8-13
15.79Single6ZG4HTL00099366ZG4-M1-HTL0009936
15.79Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
15.79Single7DFPSpiperone7DFP-D2-Spiperone
15.79Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
15.79Single7K15MKD0467K15-BLT1-MKD046-Na
15.79Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
15.79Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
15.79Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
15.79Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
15.79Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.79Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
15.79Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
15.79Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
15.79Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
15.79Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
15.79Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
15.79Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
15.79Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
15.79Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
15.79Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
15.79Consensusblt_offOrthosteric Ligandblt1_off
15.79Consensuschemokine_offOrthosteric Ligandcxcr_off
15.79Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
15.79Consensuscxcr_offOrthosteric Ligandcxcr4_off
15.79Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
15.79Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
15.79Consensusgs_steroidOrthosteric Ligandgs_bileacid
15.79Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.79Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
15.79Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
15.79Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
15.79Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
15.79Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.79Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
15.38Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
15.38Single4XNWMRS25004XNW-P2Y1-MRS2500
15.38Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
15.38Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
15.38Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.38Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
15.38Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
15.38Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
15.38Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8GGREpinephrine8GGR-β2-Epinephrine
15.38Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
15.38Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
15.38Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
15.38Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
15.38Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
15.38Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
15.38Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
15.38Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
15.38Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
15.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
15.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
15.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
15.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
15.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
15.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
15.00Single6H7LDobutamine6H7L-β1-Dobutamine
15.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
15.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
15.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
15.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
15.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
15.00Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
15.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
15.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
15.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
15.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
15.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
15.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.00Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
15.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
15.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
15.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
15.00Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
15.00Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
15.00Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
15.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
15.00Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
15.00Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
15.00Consensussteroid_onOrthosteric Ligandbileacid_on
14.81Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
14.81Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
14.81Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
14.81Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
14.81Consensusgo_class-b1Orthosteric Ligandgo_crf
14.81Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
14.71Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
14.29Single3PBLEticlopride3PBL-D3-Eticlopride
14.29Single4O9RCyclopamine4O9R-SMO-Cyclopamine
14.29Single4UG2CGS216804UG2-A2A-CGS21680
14.29Single5EE7MK08935EE7-Glucagon-MK0893
14.29Single5WF6UK-4320975WF6-A2A-UK-432097
14.29Single6HLLCP999946HLL-NK1-CP99994
14.29Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
14.29Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single6PT3DPI-2876PT3-δ-DPI-287
14.29Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
14.29Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
14.29Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
14.29Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
14.29Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single7SK9CCX6627SK9-ACKR3-CCX662
14.29Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
14.29Single7UL2SR486927UL2-NTS1-SR48692-Na
14.29Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
14.29Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
14.29Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
14.29Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
14.29Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
14.29Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
14.29Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
14.29Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
14.29Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
14.29Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GGSEpinephrine8GGS-β2-Epinephrine
14.29Single8GH1Epinephrine8GH1-β2-Epinephrine
14.29Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
14.29Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
14.29Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
14.29Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
14.29Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
14.29Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8K5BNiacin8K5B-HCA2-Niacin
14.29Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
14.29Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
14.29Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8X5YAstemizole8X5Y-H1-Astemizole
14.29Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
14.29Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
14.29Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
14.29Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
14.29Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
14.29Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
14.29Consensuslpl_onOrthosteric Ligands1p_on lpa_on
14.29Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
14.29Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
14.29Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
14.29Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
13.79Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
13.79Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
13.79Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
13.79Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
13.79Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
13.64Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
13.64Single4IARErgotamine4IAR-5-HT1B-Ergotamine
13.64Single4XT1Fractalkine4XT1-US28-Fractalkine
13.64Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
13.64Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Single7F8XNN90567F8X-CCKA-NN9056
13.64Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
13.64Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
13.64Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
13.64Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
13.64Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
13.64Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
13.64Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
13.64Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
13.33Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
13.33Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
13.33Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
13.33Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
13.33Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
13.33Single4QINSAG1.54QIN-SMO-SAG1.5
13.33Single5DHHSB-6121115DHH-NOP-SB-612111
13.33Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
13.33Single5ZKQABT-4915ZKQ-PAF-ABT-491
13.33Single6KUXRS-799486KUX-α2a-RS-79948
13.33Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
13.33Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
13.33Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
13.33Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
13.33Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
13.33Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
13.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
13.33Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
13.33Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
13.33Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
13.33Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
13.33Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
13.33Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
13.33Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
13.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
13.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.33Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
13.33Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
13.33Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
13.33Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
13.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
13.33Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
13.33Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
13.33Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
13.33Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
13.33Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
13.33Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
13.33Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
13.33Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
13.33Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
13.33Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.33Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.33Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.33Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.33Single8GGVEpinephrine8GGV-β2-Epinephrine
13.33Single8GGWEpinephrine8GGW-β2-Epinephrine
13.33Single8GGXEpinephrine8GGX-β2-Epinephrine
13.33Single8GH0Epinephrine8GH0-β2-Epinephrine
13.33Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
13.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
13.33Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.33Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.33Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.33Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.33Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.33Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.33Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
13.33Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
13.33Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
13.33Consensusalpha1_onOrthosteric Ligandalpha1a_on
13.33Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
13.33Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
13.33Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Consensusgt_class-aOrthosteric Ligandgt_opsin
13.33Consensusgt_opsinOrthosteric Ligandgt_sensory
13.33Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
13.33Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
13.33Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
13.04Single3QAKUK-4320973QAK-A2A-UK-432097
13.04Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
13.04Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
13.04Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
13.04Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
13.04Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
13.04Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
13.04Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
13.04Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
13.04Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
13.04Consensussst_offOrthosteric Ligandsst2_off
12.90Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
12.90Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
12.50Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
12.50Single3OE0CVX153OE0-CXCR4-CVX15
12.50Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
12.50Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
12.50Single5WF5UK-4320975WF5-A2A-UK-432097
12.50Single6A94Zotepine6A94-5-HT2A-Zotepine
12.50Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
12.50Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
12.50Single6PS4ICI 118-5516PS4-β2-ICI 118-551
12.50Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
12.50Single6TPKRetosiban6TPK-OT-Retosiban
12.50Single6VI4JDTic6VI4-κ-JDTic
12.50Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
12.50Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
12.50Single6ZINSR486926ZIN-NTS1-SR48692
12.50Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
12.50Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
12.50Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
12.50Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
12.50Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
12.50Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
12.50Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
12.50Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
12.50Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
12.50Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
12.50Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
12.50Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
12.50Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
12.50Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
12.50Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
12.50Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
12.50Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single7XNACYN1548067XNA-SST2-CYN154806
12.50Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
12.50Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
12.50Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
12.50Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
12.50Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
12.50Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
12.50Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
12.50Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
12.50Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
12.50Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
12.50Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
12.50Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
12.50Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
12.50Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8GGIEpinephrine8GGI-β2-Epinephrine
12.50Single8GGKEpinephrine8GGK-β2-Epinephrine
12.50Single8GGLEpinephrine8GGL-β2-Epinephrine
12.50Single8GGMEpinephrine8GGM-β2-Epinephrine
12.50Single8GGPEpinephrine8GGP-β2-Epinephrine
12.50Single8GGQEpinephrine8GGQ-β2-Epinephrine
12.50Single8GGTEpinephrine8GGT-β2-Epinephrine
12.50Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
12.50Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
12.50Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
12.50Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
12.50Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
12.50Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
12.50Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8W8SAA-148W8S-GPR101-AA-14
12.50Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
12.50Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
12.50Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
12.50Consensus5ht5_onOrthosteric Ligand5ht5a_on
12.50Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
12.50Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
12.50Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
12.50Consensusgi_class-fOrthosteric Ligandgi_frizzled
12.50Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
12.50Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
12.50Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
12.50Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
12.50Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
12.50Consensusvasopressin-ot_offOrthosteric Ligandot_off
12.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
12.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
12.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.00Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
12.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
12.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
12.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
12.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
12.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
12.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
12.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
12.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
11.76Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
11.76Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
11.76Single2Y02Carmoterol2Y02-β1-Carmoterol
11.76Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
11.76Single3NY8ICI 118-5513NY8-β2-ICI 118-551
11.76Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
11.76Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
11.76Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
11.76Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
11.76Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
11.76Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
11.76Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
11.76Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
11.76Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
11.76Single6DRXLisuride6DRX-5-HT2B-Lisuride
11.76Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
11.76Single6H7MSalbutamol6H7M-β1-Salbutamol
11.76Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
11.76Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
11.76Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
11.76Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
11.76Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
11.76Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
11.76Single7BU7BI1671077BU7-β1-BI167107
11.76Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
11.76Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
11.76Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
11.76Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
11.76Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
11.76Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
11.76Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
11.76Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
11.76Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
11.76Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
11.76Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
11.76Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
11.76Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
11.76Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
11.76Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
11.76Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
11.76Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
11.76Single7WC7Lisuride7WC7-5-HT2A-Lisuride
11.76Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
11.76Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
11.76Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
11.76Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
11.76Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.76Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
11.76Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
11.76Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
11.76Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
11.76Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.76Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.76Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.76Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.76Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.76Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.76Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.76Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.76Single8GGJEpinephrine8GGJ-β2-Epinephrine
11.76Single8GGNEpinephrine8GGN-β2-Epinephrine
11.76Single8GGOEpinephrine8GGO-β2-Epinephrine
11.76Single8GGUEpinephrine8GGU-β2-Epinephrine
11.76Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
11.76Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
11.76Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
11.76Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.76Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.76Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.76Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
11.76Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
11.76Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single8X64Desloratadine8X64-H1-Desloratadine
11.76Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
11.76Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
11.76Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
11.76Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
11.76Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
11.76Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
11.76Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
11.76Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
11.76Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
11.76Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
11.76Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
11.76Consensusblt_onOrthosteric Ligandblt1_on
11.76Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
11.76Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
11.76Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
11.76Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
11.76Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
11.76Consensusleuko_onOrthosteric Ligandblt_on
11.76Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
11.76Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
11.76Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
11.76Consensustar_onOrthosteric Ligandta1_on
11.54Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
11.54Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
11.54Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
11.54Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
11.54Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
11.54Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
11.54Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
11.54Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
11.11Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
11.11Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
11.11Single4NTJAZD12834NTJ-P2Y12-AZD1283
11.11Single4XT3Fractalkine4XT3-US28-Fractalkine
11.11Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
11.11Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
11.11Single5TVNLSD5TVN-5-HT2B-LSD
11.11Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
11.11Single6D26Fevipiprant6D26-DP2-Fevipiprant
11.11Single6E67BI1671076E67-β2-BI167107-Gs (fused)
11.11Single6FJ3PTH6FJ3-PTH1-PTH
11.11Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
11.11Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
11.11Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
11.11Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
11.11Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
11.11Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
11.11Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
11.11Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
11.11Single6Z4SSR486926Z4S-NTS1-SR48692
11.11Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
11.11Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
11.11Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
11.11Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
11.11Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
11.11Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
11.11Single7SINNPS-21437SIN-CaS-NPS-2143
11.11Single7SINNPS-21437SIN-CaS-NPS-2143
11.11Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
11.11Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
11.11Single7WC6LSD7WC6-5-HT2A-LSD
11.11Single7XKAEpinephrine7XKA-β2-Epinephrine
11.11Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
11.11Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
11.11Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
11.11Single8GNEKW-63568GNE-A2A-KW-6356-Na
11.11Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
11.11Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
11.11Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.11Single8W8RAA-148W8R-GPR101-AA-14-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
11.11Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
11.11Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
11.11Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
11.11Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
11.11Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
11.11Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
11.11Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
11.11Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
11.11Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
11.11Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
11.11Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
11.11Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
11.11Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
11.11Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
11.11Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
10.71Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
10.71Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
10.71Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
10.71Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.53Single2YDVNECA2YDV-A2A-NECA
10.53Single3P0GBI1671073P0G-β2-BI167107
10.53Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
10.53Single4U15Tiotropium4U15-M3-Tiotropium
10.53Single4UHRCGS216804UHR-A2A-CGS21680
10.53Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
10.53Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
10.53Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
10.53Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
10.53Single5G53NECA5G53-A2A-NECA-Gs
10.53Single5V54Methiothepin5V54-5-HT1B-Methiothepin
10.53Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
10.53Single6E59L-7607356E59-NK1-L-760735
10.53Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
10.53Single6J20Aprepitant6J20-NK1-Aprepitant
10.53Single6J21Aprepitant6J21-NK1-Aprepitant
10.53Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
10.53Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
10.53Single6OL9Tiotropium6OL9-M5-Tiotropium
10.53Single6OS1TRV0266OS1-AT1-TRV026
10.53Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
10.53Single6WGTLSD6WGT-5-HT2A-LSD
10.53Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
10.53Single7B6WCyclazosin7B6W-α1b-Cyclazosin
10.53Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
10.53Single7EPENAM5637EPE-mGlu-NAM563
10.53Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
10.53Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
10.53Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
10.53Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
10.53Single7TUYGSK682753A7TUY-GPR183-GSK682753A
10.53Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
10.53Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
10.53Single7W41PD1762527W41-BB2-PD176252
10.53Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
10.53Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
10.53Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
10.53Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
10.53Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
10.53Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.53Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
10.53Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
10.53Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
10.53Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
10.53Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
10.53Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
10.53Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
10.53Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
10.53Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
10.53Consensus5ht1_offOrthosteric Ligand5ht1b_off
10.53Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
10.53Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
10.53Consensus5ht5_offOrthosteric Ligand5ht5a_off
10.53Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
10.53Consensusa2_onOrthosteric Liganda2a_on a2b_on
10.53Consensusadenosine_offOrthosteric Liganda1_off a2_off
10.53Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
10.53Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
10.53Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
10.53Consensusbombesin_offOrthosteric Ligandbb2_off
10.53Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
10.53Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
10.53Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
10.53Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
10.53Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
10.53Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
10.53Consensushistamine_offOrthosteric Ligandh1_off
10.53Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.53Consensuslpa_offOrthosteric Ligandlpa1_off
10.53Consensuslpa_onOrthosteric Ligandlpa1_on
10.53Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
10.53Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
10.53Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
10.53Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
10.53Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
10.34Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
10.34Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
10.34Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
10.34Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
10.34Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
10.34Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
10.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
10.00Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
10.00Single4AMIBucindolol4AMI-β1-Bucindolol
10.00Single4N4WSANT-14N4W-SMO-SANT-1
10.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
10.00Single5CXVTiotropium5CXV-M1-Tiotropium
10.00Single6A93Risperidone6A93-5-HT2A-Risperidone
10.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
10.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
10.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
10.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
10.00Single6OS2TRV0266OS2-AT1-TRV026
10.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
10.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
10.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
10.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
10.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
10.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
10.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
10.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
10.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
10.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
10.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
10.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single8JJ8Formoterol8JJ8-β2-Formoterol
10.00Single8JJLOlodaterol8JJL-β2-Olodaterol
10.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
10.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
10.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
10.00Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
10.00Consensusdp_offOrthosteric Liganddp2_off
10.00Consensusgi_class-fOther Ligandgi_frizzled
10.00Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
10.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
10.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
10.00Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
10.00Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
10.00Consensusnts_offOrthosteric Ligandnts1_off
10.00Consensusnts_onOrthosteric Ligandnts1_on
9.68Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
9.68Consensusglp_onOrthosteric Ligandglp1_on glp2_on
9.52Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
9.52Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
9.52Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
9.52Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
9.52Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
9.52Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
9.52Single6IBLArformoterol6IBL-β1-Arformoterol
9.52Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
9.52Single7EZCUKA7EZC-A2A-UKA
9.52Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
9.52Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
9.52Single7UM4AS26747237UM4-5-HT5A-AS2674723
9.52Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
9.52Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
9.52Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
9.52Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
9.52Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
9.52Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
9.52Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
9.52Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
9.38Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
9.09Single3NY9PubChem 9131033NY9-β2-PubChem 913103
9.09Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
9.09Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
9.09Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
9.09Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
9.09Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
9.09Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
9.09Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
9.09Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
9.09Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
9.09Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
8.82Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
8.82Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
8.70Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
8.70Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
8.70Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
8.70Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
8.70Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
8.33Single6HLOAprepitant6HLO-NK1-Aprepitant
8.33Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
8.33Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
8.33Single7WC4Serotonin7WC4-5-HT2A-Serotonin
8.33Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
8.11Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
8.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
8.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
7.89Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
7.69Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
7.69Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
7.69Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
7.69Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
7.69Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
7.69Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
7.69Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
7.69Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
7.41Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
7.41Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
7.41Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
7.14Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
7.14Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
7.14Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
7.14Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
7.14Single6ME5Agomelatine6ME5-MT1-Agomelatine
7.14Single6ME9Ramelteon6ME9-MT2-Ramelteon
7.14Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
7.14Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
7.14Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
7.14Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
7.14Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
7.14Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
7.14Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
7.14Single7WC5Psilocin7WC5-5-HT2A-Psilocin
7.14Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
7.14Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
7.14Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
7.14Single8GGZEpinephrine8GGZ-β2-Epinephrine
7.14Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
7.14Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
7.14Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
7.14Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
7.14Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
7.14Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
7.14Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
7.14Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
7.14Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
7.14Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
7.14Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
6.90Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.90Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
6.67Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
6.67Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
6.67Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
6.67Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
6.67Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
6.67Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
6.67Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
6.67Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
6.67Single6LMLGlucagon6LML-Glucagon-Glucagon
6.67Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
6.67Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
6.67Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
6.67Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
6.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
6.67Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67Single7SRQLSD7SRQ-5-HT2B-LSD
6.67Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
6.67Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.67Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
6.67Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
6.67Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
6.67Single8GGYEpinephrine8GGY-β2-Epinephrine
6.67Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
6.67Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
6.67Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
6.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
6.67Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
6.67Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
6.67Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
6.67Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
6.67Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
6.67Consensusgo_proteinOrthosteric Ligandgo_chemokine
6.67Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
6.45Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
6.45Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
6.45Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
6.25Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
6.25Single4BWBNeurotensin4BWB-NTS1-Neurotensin
6.25Single5K2DZM2413855K2D-A2A-ZM241385
6.25Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
6.25Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
6.25Single6JZHZM2413856JZH-A2A-ZM241385-Na
6.25Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
6.25Single6ME2Ramelteon6ME2-MT1-Ramelteon
6.25Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
6.25Single6PS7ZM2413856PS7-A2A-ZM241385-Na
6.25Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
6.25Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
6.25Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
6.25Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
6.25Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
6.25Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
6.25Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
6.25Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
6.25Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
6.25Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
6.25Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
6.25Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
6.25Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
6.25Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
6.25Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
6.25Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
6.25Single8GNGIstradefylline8GNG-A2A-Istradefylline
6.25Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
6.25Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
6.25Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single8IWESpermidine8IWE-TAAR9-Spermidine
6.25Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
6.25Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
6.25Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
6.25Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
6.25Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
6.25Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
6.25Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
6.25Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
6.25Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
6.25Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
6.25Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
6.25Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
6.25Consensusmglu_onOther Ligandmglu2_on mglu4_on
6.25Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
6.25Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
6.06Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
6.06Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
6.06Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
5.88Single2YDOAdenosine2YDO-A2A-Adenosine
5.88Single3RZECidoxepin3RZE-H1-Cidoxepin
5.88Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
5.88Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
5.88Single5IU4ZM2413855IU4-A2A-ZM241385-Na
5.88Single5IU7Q274563465IU7-A2A-Q27456346-Na
5.88Single5IUBQ274563445IUB-A2A-Q27456344-Na
5.88Single5JTBZM2413855JTB-A2A-ZM241385
5.88Single5K2BZM2413855K2B-A2A-ZM241385-Na
5.88Single5K2CZM2413855K2C-A2A-ZM241385-Na
5.88Single5NLXZM2413855NLX-A2A-ZM241385-Na
5.88Single5NM4ZM2413855NM4-A2A-ZM241385-Na
5.88Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
5.88Single5UVIZM2413855UVI-A2A-ZM241385
5.88Single6DS0Ly2660976DS0-5-HT2B-Ly266097
5.88Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
5.88Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
5.88Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
5.88Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
5.88Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
5.88Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
5.88Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
5.88Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
5.88Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
5.88Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
5.88Single7AROLUF58337ARO-A2A-LUF5833-Na
5.88Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
5.88Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
5.88Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
5.88Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
5.88Single7T32ZM2413857T32-A2A-ZM241385
5.88Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.88Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
5.88Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
5.88Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.88Single7VODCariprazine7VOD-5-HT2A-Cariprazine
5.88Single7VV6C48/807VV6-MRGPRX2-C48/80
5.88Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
5.88Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
5.88Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
5.88Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.88Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
5.88Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
5.88Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
5.88Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
5.88Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
5.88Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
5.88Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
5.88Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.88Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
5.88Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
5.88Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
5.88Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
5.88Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
5.88Consensussensory_offOrthosteric Ligandopsin_off
5.56Single3EMLZM2413853EML-A2A-ZM241385
5.56Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
5.56Single4DAJTiotropium4DAJ-M3-Tiotropium
5.56Single4EIYZM2413854EIY-A2A-ZM241385-Na
5.56Single4MQSIperoxo4MQS-M2-Iperoxo
5.56Single4U14Tiotropium4U14-M3-Tiotropium
5.56Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
5.56Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
5.56Single5IU8Q274563475IU8-A2A-Q27456347-Na
5.56Single5K2AZM2413855K2A-A2A-ZM241385-Na
5.56Single5OLGZM2413855OLG-A2A-ZM241385-Na
5.56Single5UENDU1725UEN-A1-DU172
5.56Single5VRAZM2413855VRA-A2A-ZM241385-Na
5.56Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
5.56Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
5.56Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
5.56Single6D27CAY104716D27-DP2-CAY10471
5.56Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
5.56Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
5.56Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
5.56Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
5.56Single6LPJZM2413856LPJ-A2A-ZM241385-Na
5.56Single6LPKZM2413856LPK-A2A-ZM241385-Na
5.56Single6PS1Timolol6PS1-β2-Timolol
5.56Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
5.56Single6S0LZM2413856S0L-A2A-ZM241385
5.56Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.56Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
5.56Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.56Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
5.56Single7PYRPSB-21157PYR-A2A-PSB-2115
5.56Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
5.56Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
5.56Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
5.56Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
5.56Single8CU6LJ-45178CU6-A2A-LJ-4517
5.56Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
5.56Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.56Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.56Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.56Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
5.56Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
5.56Single8JJOAlprenolol8JJO-β2-Alprenolol
5.56Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
5.56Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
5.56Single8X63Mepyramine8X63-H1-Mepyramine
5.56Consensusa2_offOrthosteric Liganda2a_off
5.56Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
5.56Consensusadenosine_onOrthosteric Liganda1_on a2_on
5.56Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
5.56Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
5.56Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
5.56Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
5.56Consensushistamine_onOrthosteric Ligandh1_on h4_on
5.56Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.56Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.56Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
5.56Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
5.56Consensusnucleotide_onOrthosteric Ligandadenosine_on
5.56Consensustachykinin_offOrthosteric Ligandnk1_off
5.41Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
5.26Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
5.26Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
5.26Single5CGCHTL142425CGC-mGlu5-HTL14242
5.26Single5IUAQ274563485IUA-A2A-Q27456348-Na
5.26Single5NM2ZM2413855NM2-A2A-ZM241385-Na
5.26Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
5.26Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.26Single6LPLZM2413856LPL-A2A-ZM241385-Na
5.26Single6LUQHaloperidol6LUQ-D2-Haloperidol
5.26Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
5.26Single6PS6Timolol6PS6-β2-Timolol
5.26Single6S0QZM2413856S0Q-A2A-ZM241385
5.26Single6WQAZM2413856WQA-A2A-ZM241385-Na
5.26Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
5.26Single7RM5ZM2413857RM5-A2A-ZM241385-Na
5.26Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
5.26Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
5.26Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
5.26Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
5.26Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single8EA0Iperoxo8EA0-M3-Iperoxo
5.26Single8FYNZM2413858FYN-A2A-ZM241385-Na
5.26Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
5.26Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.26Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
5.26Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
5.26Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
5.26Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
5.26Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
5.26Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.13Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
5.13Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.00Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
5.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
5.00Single5TZR-5TZR-FFA1 (GPR40)-MK8666
5.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
5.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
5.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
5.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.00Single7PX4PSB-21137PX4-A2A-PSB-2113
5.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
5.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
5.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
5.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
5.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
5.00Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
5.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
5.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
5.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
5.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
5.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
5.00Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.88Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
4.76Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.76Single6CM4Risperidone6CM4-D2-Risperidone
4.76Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
4.76Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
4.76Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
4.76Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
4.76Single8JWZAB9288JWZ-A2A-AB928-Na
4.76Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.76Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.76Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
4.76Consensusclass-b2_onOrthosteric Ligandadgrg_on
4.76Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
4.55Single5CGDHTL142425CGD-mGlu5-HTL14242
4.55Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
4.55Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
4.55Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
4.55Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
4.55Consensuscyslt_offOrthosteric Ligandcyslt2_off
4.55Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single6KNMJN241-96KNM-Apelin-JN241-9
4.35Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
4.35Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
4.35Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Consensusgs_class-b2Orthosteric Ligandgs_adgr
4.17Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
4.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
4.00Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
3.70Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
3.57Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
3.57Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
3.57Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.45Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
3.45Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
3.33Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
3.33Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
3.33Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
3.33Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.23Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
3.23Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
3.23Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
3.12Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.12Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
3.12Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
3.12Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
3.12Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
2.94Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
2.86Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
2.78Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
2.56Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2

Consensus Members
Id Members
7XP6 7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
Net Summary
Imin 2.85
Number of Linked Nodes 262
Number of Links 297
Number of Hubs 45
Number of Links mediated by Hubs 162
Number of Communities 6
Number of Nodes involved in Communities 59
Number of Links involved in Communities 82
Path Summary
Number Of Nodes in MetaPath 79
Number Of Links MetaPath 78
Number of Shortest Paths 66175
Length Of Smallest Path 3
Average Path Length 14.0408
Length of Longest Path 29
Minimum Path Strength 1.36
Average Path Strength 6.05831
Maximum Path Strength 22.46
Minimum Path Correlation 0.7
Average Path Correlation 0.935227
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 5
Average % Of Corr. Nodes 45.8506
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.1327
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
class-t_ontaste2_on



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