psnGPCR

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Orange: nodes, hubs and links specific of chemokine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of chemokine_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	chemokine_off Int. Strength	chemokine_on Int. Strength	chemokine_off Hub1?	chemokine_on Hub1?	chemokine_off Hub2?	chemokine_on Hub2?	ConSurf1	ConSurf2
1	1x24	NT	chemokine_off	9.75	0	Yes	No	Yes	Yes	5	4
2	1x24	7x27	chemokine_off	9.3	0	Yes	No	No	No	5	2
3	1x24	7x28	chemokine_off	7.23	0	Yes	No	No	No	5	3
4	1x26	1x27	chemokine_off	3.94	0	Yes	No	Yes	No	4	6
5	1x26	7x25	chemokine_off	7.61	0	Yes	No	No	No	4	3
6	1x26	7x28	chemokine_off	14.46	0	Yes	No	No	No	4	3
7	1x26	7x32	chemokine_off	4.05	0	Yes	No	No	No	4	2
8	1x27	7x31	chemokine_off	10.2	0	Yes	No	No	No	6	4
9	1x27	7x32	chemokine_off	6.99	0	Yes	No	No	No	6	2
10	1x30	1x31	chemokine_off	6.04	0	Yes	No	No	No	4	3
11	1x30	1x34	chemokine_off	4.29	0	Yes	No	No	No	4	5
12	1x30	7x32	chemokine_off	16.13	0	Yes	No	No	No	4	2
13	1x30	7x36	chemokine_off	8.79	0	Yes	No	No	No	4	6
14	1x31	1x35	chemokine_off	9.61	0	No	No	No	No	3	6
15	1x31	7x35	chemokine_off	5.96	0	No	No	No	No	3	5
16	1x34	7x36	chemokine_off	3.77	0	No	No	No	No	5	6
17	1x38	7x40	chemokine_off	7.14	0	No	No	No	No	5	7
18	1x39	2x60	chemokine_off	3.86	0	Yes	Yes	Yes	Yes	7	7
19	1x42	7x43	chemokine_off	3.77	0	No	No	Yes	No	7	5
20	1x46	2x54	chemokine_off	3.68	0	No	No	Yes	No	8	6
21	1x47	2x54	chemokine_off	4.61	0	No	Yes	Yes	No	5	6
22	1x54	2x51	chemokine_off	5.71	0	No	No	No	No	7	7
23	1x56	1x60	chemokine_off	4.3	0	No	No	No	No	7	4
24	1x57	2x40	chemokine_off	8.32	0	No	No	No	No	6	8
25	2x40	2x43	chemokine_off	4.76	0	No	No	No	No	8	8
26	2x42	4x41	chemokine_off	5.34	0	Yes	Yes	No	No	7	3
27	2x43	7x49	chemokine_off	8.44	0	No	No	No	Yes	8	9
28	2x45	4x45	chemokine_off	6.92	0	Yes	No	No	No	9	5
29	2x52	3x31	chemokine_off	8.56	0	No	No	No	No	7	5
30	2x53	2x60	chemokine_off	6.01	0	Yes	Yes	Yes	Yes	7	7
31	2x59	E1x52	chemokine_off	10.72	0	No	No	Yes	No	6	7
32	2x60	7x38	chemokine_off	8.72	0	Yes	Yes	Yes	No	7	5
33	2x60	7x42	chemokine_off	8.02	0	Yes	Yes	Yes	Yes	7	7
34	2x62	E1x52	chemokine_off	6.55	0	No	No	Yes	No	5	7
35	2x63	E2	chemokine_off	4.76	0	No	No	Yes	Yes	5	3
36	2x63	Lig	chemokine_off	16.86	0	No	No	Yes	Yes	5	0
37	2x66	E1x51	chemokine_off	4	0	No	No	No	No	5	3
38	E1x49	E1x51	chemokine_off	8.14	0	No	No	No	No	4	3
39	E1x50	E1x52	chemokine_off	17.04	0	Yes	No	Yes	No	9	7
40	E1x50	E2	chemokine_off	4.9	0	Yes	No	Yes	Yes	9	3
41	E1x50	Lig	chemokine_off	4.56	0	Yes	No	Yes	Yes	9	0
42	3x22	3x26	chemokine_off	4.2	0	No	No	No	No	3	7
43	3x28	Lig	chemokine_off	4.47	0	No	No	Yes	Yes	5	0
44	3x29	4x61	chemokine_off	6.3	0	Yes	No	No	Yes	6	4
45	3x29	E2x52	chemokine_off	5.64	0	Yes	No	Yes	No	6	5
46	3x29	Lig	chemokine_off	3.86	0	Yes	No	Yes	Yes	6	0
47	3x30	4x57	chemokine_off	9.52	0	No	No	No	No	5	6
48	3x32	3x36	chemokine_off	9.38	0	Yes	Yes	No	Yes	6	7
49	3x32	7x42	chemokine_off	6.19	0	Yes	Yes	Yes	Yes	6	7
50	3x35	7x45	chemokine_off	5.1	0	No	No	Yes	No	8	9
51	3x37	5x46	chemokine_off	6.31	0	No	Yes	No	No	7	4
52	3x39	6x44	chemokine_off	3.96	0	No	No	Yes	Yes	9	9
53	3x40	5x50	chemokine_off	7.07	0	No	Yes	No	No	7	9
54	3x41	3x44	chemokine_off	3.89	0	Yes	No	No	No	5	7
55	3x41	4x49	chemokine_off	3.68	0	Yes	No	No	No	5	7
56	3x41	5x50	chemokine_off	16.21	0	Yes	No	No	No	5	9
57	3x43	6x41	chemokine_off	8.56	0	No	No	No	No	8	7
58	3x45	4x40	chemokine_off	6.09	0	Yes	No	No	No	5	4
59	3x45	4x44	chemokine_off	3.93	0	Yes	No	No	No	5	2
60	3x45	4x49	chemokine_off	5.24	0	Yes	No	No	No	5	7
61	3x46	6x37	chemokine_off	4.56	0	No	No	No	No	8	7
62	3x49	3x50	chemokine_off	8.34	0	No	No	Yes	No	8	9
63	3x50	I2x57	chemokine_off	4.26	0	Yes	No	Yes	No	9	6
64	3x50	6x37	chemokine_off	3.88	0	Yes	No	No	No	9	7
65	3x51	3x52	chemokine_off	4.69	0	Yes	Yes	No	No	8	5
66	I2x53	I2x57	chemokine_off	3.95	0	No	No	Yes	No	5	6
67	4x39	I2x55	chemokine_off	4.86	0	No	No	No	No	4	5
68	4x38	4x42	chemokine_off	13.5	0	No	No	No	No	6	7
69	4x39	4x43	chemokine_off	5.64	0	No	No	No	No	4	3
70	4x42	4x43	chemokine_off	5.4	0	No	No	No	No	7	3
71	4x45	4x46	chemokine_off	5.05	0	No	No	No	No	5	7
72	4x46	4x50	chemokine_off	6.75	0	No	No	No	Yes	7	9
73	4x48	4x52	chemokine_off	4.06	0	No	No	No	No	3	4
74	4x56	5x42	chemokine_off	3.99	0	No	No	No	No	5	3
75	4x60	E2x52	chemokine_off	7.21	0	No	No	Yes	No	8	5
76	4x60	5x39	chemokine_off	7.22	0	No	No	No	No	8	5
77	5x36	E2	chemokine_off	6.31	0	No	No	Yes	Yes	4	3
78	5x34	E2	chemokine_off	5.49	0	No	No	Yes	Yes	2	3
79	5x43	6x52	chemokine_off	4.36	0	No	No	No	No	4	8
80	5x45	5x49	chemokine_off	4.24	0	No	No	No	No	4	6
81	5x58	5x62	chemokine_off	8.46	0	No	Yes	No	No	8	4
82	I3	I3	chemokine_off	4.77	0	Yes	No	Yes	No	4	4
83	6x33	6x36	chemokine_off	3.74	0	No	No	No	No	7	7
84	6x35	6x39	chemokine_off	4.36	0	No	No	No	No	6	5
85	6x43	7x48	chemokine_off	4.73	0	No	No	No	No	6	6
86	6x44	6x45	chemokine_off	6.43	0	Yes	Yes	No	No	9	4
87	6x44	7x45	chemokine_off	7.92	0	Yes	Yes	Yes	No	9	9
88	6x48	6x52	chemokine_off	5.79	0	Yes	Yes	No	No	9	8
89	6x58	7x34	chemokine_off	4.2	0	No	Yes	No	No	5	4
90	6x61	7x26	chemokine_off	5.02	0	No	No	No	No	3	1
91	7x31	7x35	chemokine_off	8.37	0	No	No	No	No	4	5
92	7x33	7x37	chemokine_off	9.7	0	No	No	No	No	6	6
93	7x43	7x47	chemokine_off	5.59	0	Yes	No	No	No	5	7
94	7x45	7x46	chemokine_off	7.37	0	Yes	No	No	No	9	9
95	3x52	I2x57	chemokine_off	3.64	0	No	No	Yes	No	5	6
96	2x49	3x38	chemokine_off	3.42	0	No	No	No	No	8	7
97	3x44	5x53	chemokine_off	3.39	0	No	No	No	No	7	6
98	4x51	4x52	chemokine_off	3.39	0	No	No	No	No	4	4
99	6x35	6x36	chemokine_off	3.35	0	No	No	No	No	6	7
100	3x52	I2x56	chemokine_off	3.28	0	No	No	No	No	5	4
101	3x44	5x54	chemokine_off	3.25	0	No	No	No	Yes	7	7
102	3x53	6x32	chemokine_off	3.21	0	No	No	Yes	No	8	8
103	3x33	4x57	chemokine_off	3.14	0	No	Yes	No	No	5	6
104	1x54	2x47	chemokine_off	3.1	0	No	No	No	No	7	9
105	6x57	7x30	chemokine_off	3.07	0	No	No	No	No	5	5
106	6x61	7x30	chemokine_off	3.07	0	No	No	No	No	3	5
107	1x45	7x51	chemokine_off	3.04	0	No	No	No	No	5	6
108	2x54	2x57	chemokine_off	2.98	0	Yes	No	No	Yes	6	8
109	6x34	6x38	chemokine_off	2.98	0	No	No	No	No	5	4
110	5x44	5x48	chemokine_off	2.94	0	No	No	No	No	5	4
111	6x58	7x30	chemokine_off	2.92	0	No	Yes	No	No	5	5
112	3x54	6x32	chemokine_off	2.91	0	No	No	Yes	No	8	8
113	2x38	4x38	chemokine_off	2.88	0	No	No	No	No	6	6
114	I2x55	I2x56	chemokine_off	2.88	0	No	No	No	No	5	4
115	3x21	E1x50	chemokine_off	2.81	0	No	No	Yes	No	8	9
116	6x47	7x43	chemokine_off	2.79	0	No	No	Yes	No	8	5
117	3x43	6x40	chemokine_off	2.77	0	No	No	No	No	8	7
118	6x40	7x48	chemokine_off	2.77	0	No	No	No	No	7	6
119	4x38	I2x54	chemokine_off	2.71	0	No	No	No	No	6	5
120	5x38	5x39	chemokine_off	2.62	0	No	No	No	No	3	5
121	7x43	7x48	chemokine_off	2.44	0	Yes	No	No	No	5	6
122	3x51	5x61	chemokine_off	2.42	0	Yes	Yes	No	No	8	8
123	6x53	7x33	chemokine_off	2.35	0	No	No	No	No	6	6
124	3x41	5x49	chemokine_off	2.28	0	Yes	No	No	No	5	6
125	1x51	2x51	chemokine_off	1.71	0	No	No	No	No	3	7
126	6x36	7x52	chemokine_off	1.64	0	No	No	No	No	7	7
127	7x23	E3	chemokine_off	1.64	0	No	No	Yes	Yes	5	3
128	3x34	3x38	chemokine_off	1.62	0	No	No	No	No	5	7
129	1x28	1x32	chemokine_off	1.61	0	No	No	No	No	1	4
130	6x32	I2x50	chemokine_off	1.61	0	Yes	No	No	No	8	8
131	1x35	2x64	chemokine_off	1.58	0	No	No	No	No	6	5
132	6x55	6x59	chemokine_off	1.55	0	No	No	No	No	5	5
133	1x47	1x48	chemokine_off	1.54	0	No	Yes	No	No	5	4
134	6x38	6x39	chemokine_off	1.54	0	No	No	No	No	4	5
135	1x32	2x65	chemokine_off	1.52	0	No	No	No	No	4	4
136	1x41	1x45	chemokine_off	1.52	0	No	No	No	No	4	5
137	2x55	2x56	chemokine_off	1.52	0	No	No	No	No	4	6
138	3x45	4x48	chemokine_off	1.51	0	Yes	No	No	No	5	3
139	1x48	1x52	chemokine_off	1.49	0	No	No	No	No	4	5
140	6x38	6x42	chemokine_off	1.49	0	No	No	No	No	4	5
141	5x33	5x36	chemokine_off	1.46	0	No	No	No	No	1	4
142	3x54	5x65	chemokine_off	1.43	0	No	No	No	No	8	8
143	4x51	4x55	chemokine_off	1.43	0	No	No	No	No	4	4
144	5x36	5x40	chemokine_off	1.43	0	No	No	No	No	4	5
145	1x33	1x34	chemokine_off	1.26	0	No	No	No	No	5	5
146	3x23	3x24	chemokine_off	1.22	0	No	No	No	Yes	1	5
147	6x31	I3	chemokine_off	1.17	0	No	No	Yes	No	5	4
148	Lig	NT	Shared	62.43	30.57	Yes	Yes	Yes	Yes	0	4
149	NT	NT	Shared	10.09	18.055	Yes	Yes	Yes	Yes	4	4
150	7x24	NT	Shared	7.28	3.64	No	No	Yes	Yes	5	4
151	1x25	NT	Shared	9.33	1.45	No	No	Yes	Yes	5	4
152	1x24	Lig	Shared	17.72	3.86	Yes	No	Yes	Yes	5	0
153	1x27	7x28	Shared	12.26	5.815	Yes	No	No	No	6	3
154	1x35	1x39	Shared	5.86	7.7525	No	No	Yes	Yes	6	7
155	1x39	2x61	Shared	4	3.875	Yes	Yes	No	No	7	7
156	1x39	7x39	Shared	6.67	4.33	Yes	Yes	No	No	7	4
157	1x39	7x42	Shared	5.16	20.8075	Yes	Yes	Yes	Yes	7	7
158	1x43	2x58	Shared	7.22	9.3875	No	Yes	No	No	6	9
159	1x45	7x47	Shared	6.76	4.8075	No	No	No	No	5	7
160	1x49	7x50	Shared	4.06	2.5375	No	No	Yes	Yes	8	9
161	1x50	2x50	Shared	13.46	11.1075	No	Yes	No	No	9	9
162	1x50	7x50	Shared	11.4	6.5175	No	Yes	Yes	Yes	9	9
163	1x53	2x47	Shared	6.46	2.545	No	No	No	No	8	9
164	1x57	2x44	Shared	4.24	4.91	No	No	No	No	6	5
165	2x37	2x40	Shared	10.31	9.5725	No	No	No	No	7	8
166	2x38	I2x57	Shared	6.2	7.5475	No	No	Yes	No	6	6
167	2x39	3x50	Shared	5.17	3.235	No	No	Yes	No	7	9
168	2x42	3x45	Shared	7.22	4.5	Yes	Yes	Yes	No	7	5
169	2x42	3x46	Shared	6.04	5.4425	Yes	Yes	No	No	7	8
170	2x42	3x49	Shared	5.75	4.0225	Yes	Yes	No	No	7	8
171	2x43	7x53	Shared	17.49	4.1	No	No	No	Yes	8	9
172	2x45	4x46	Shared	6.53	8.7575	Yes	No	No	No	9	7
173	2x45	4x50	Shared	8.46	4.8025	Yes	No	No	Yes	9	9
174	2x46	3x42	Shared	5.71	3.295	No	Yes	No	Yes	9	7
175	2x46	7x49	Shared	8.24	6.52	No	Yes	No	Yes	9	9
176	2x50	7x46	Shared	4.67	6.7925	No	No	No	No	9	9
177	2x53	2x57	Shared	4.87	6.09	Yes	Yes	No	Yes	7	8
178	2x53	3x32	Shared	5.16	6.005	Yes	Yes	Yes	Yes	7	6
179	2x53	3x35	Shared	12.08	4.53	Yes	Yes	No	No	7	8
180	2x53	7x42	Shared	11.79	7.8625	Yes	Yes	Yes	Yes	7	7
181	2x56	3x28	Shared	4.76	3.1475	No	No	No	No	6	5
182	2x56	3x31	Shared	9.12	3.505	No	No	No	No	6	5
183	2x59	3x28	Shared	3.93	8.6725	No	No	No	No	6	5
184	2x60	3x32	Shared	14.47	6.3	Yes	Yes	Yes	Yes	7	6
185	2x60	Lig	Shared	12.53	9.05	Yes	Yes	Yes	Yes	7	0
186	2x63	E1x50	Shared	4.47	3.3975	No	No	Yes	No	5	9
187	E1x49	E2	Shared	21.4	1.855	No	No	Yes	Yes	4	3
188	3x25	E1x50	Shared	3.92	3.265	No	No	Yes	No	9	9
189	E1x50	E2x50	Shared	14.37	3.9175	Yes	No	No	No	9	9
190	3x22	E2	Shared	10	3.165	No	No	Yes	Yes	3	3
191	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
192	3x29	4x65	Shared	8.78	7.83	Yes	No	No	No	6	4
193	3x30	4x62	Shared	9.18	8.24	No	No	No	No	5	4
194	3x33	4x61	Shared	11.56	9.5475	No	Yes	No	Yes	5	4
195	3x37	4x56	Shared	8.21	9.125	No	Yes	No	No	7	5
196	3x37	5x43	Shared	6.53	4.03	No	Yes	No	No	7	4
197	3x38	4x50	Shared	6.18	7.105	No	No	No	Yes	7	9
198	3x40	3x41	Shared	3.68	3.14	No	Yes	Yes	No	7	5
199	3x40	6x44	Shared	3.93	4.7075	No	Yes	Yes	Yes	7	9
200	3x43	6x44	Shared	8.53	5.485	No	No	Yes	Yes	8	9
201	3x47	5x54	Shared	9.29	4.9825	No	No	No	Yes	9	7
202	3x48	5x53	Shared	4.47	1.87	No	No	No	No	6	6
203	3x49	I2x57	Shared	11.91	7.6275	No	No	Yes	No	8	6
204	3x51	3x55	Shared	6.31	9.7775	Yes	Yes	No	No	8	7
205	3x51	3x56	Shared	10.89	4.435	Yes	Yes	No	Yes	8	6
206	3x51	5x60	Shared	6.04	6.4375	Yes	Yes	No	No	8	4
207	3x53	I2x57	Shared	6.91	2.6975	No	No	Yes	No	8	6
208	3x55	3x56	Shared	11.07	4.71	No	No	No	Yes	7	6
209	3x55	5x64	Shared	6.07	5.555	No	No	No	No	7	4
210	4x40	4x44	Shared	4.47	2.125	No	No	No	No	4	2
211	4x57	4x62	Shared	3.89	2.08	No	No	No	No	6	4
212	4x61	E2x52	Shared	13.1	3.305	No	Yes	Yes	No	4	5
213	4x63	4x64	Shared	11.3	5.5475	No	No	No	No	3	4
214	4x64	E2	Shared	14.24	8.66	No	No	Yes	Yes	4	3
215	4x64	5x35	Shared	5.01	5.01	No	No	No	No	4	5
216	E2	E2	Shared	43.15	34.31	Yes	Yes	Yes	Yes	3	3
217	E2	Lig	Shared	37.32	40.86	Yes	Yes	Yes	Yes	3	0
218	E2	E2x51	Shared	11.89	5.26	Yes	Yes	No	No	3	3
219	E2x51	Lig	Shared	7.28	12.8525	No	No	Yes	Yes	3	0
220	E2	E2x52	Shared	13.38	4.6775	Yes	Yes	Yes	No	3	5
221	5x35	E2	Shared	24.31	10.88	No	No	Yes	Yes	5	3
222	5x39	E2	Shared	10.32	3.6	No	No	Yes	Yes	5	3
223	5x45	5x48	Shared	5.83	1.995	No	No	No	No	4	4
224	5x461	5x50	Shared	4.06	2.03	No	No	No	No	5	9
225	5x47	6x52	Shared	8.21	13.8975	No	Yes	No	No	8	8
226	6x44	6x48	Shared	8.02	10.0225	Yes	Yes	Yes	Yes	9	9
227	6x48	6x51	Shared	6.75	5.785	Yes	Yes	Yes	Yes	9	7
228	6x48	7x41	Shared	6.48	6.705	Yes	Yes	No	No	9	8
229	6x48	7x45	Shared	8.46	5.025	Yes	Yes	Yes	No	9	9
230	6x51	6x55	Shared	6.04	6.245	Yes	Yes	No	No	7	5
231	6x51	7x37	Shared	6.24	5.93	Yes	Yes	No	No	7	6
232	6x51	7x38	Shared	13.47	5.3325	Yes	Yes	Yes	No	7	5
233	6x58	Lig	Shared	17.31	4.165	No	Yes	Yes	Yes	5	0
234	6x60	E3	Shared	13.82	14.19	No	No	Yes	Yes	4	3
235	E3	E3	Shared	4.21	15.1375	Yes	Yes	Yes	Yes	3	3
236	7x26	E3	Shared	17.82	6.81	No	No	Yes	Yes	1	3
237	7x27	Lig	Shared	21.75	18.1525	No	No	Yes	Yes	2	0
238	7x31	Lig	Shared	13.07	6.6225	No	No	Yes	Yes	4	0
239	7x38	7x42	Shared	4.66	4.3725	Yes	No	Yes	Yes	5	7
240	7x38	Lig	Shared	9.44	12.925	Yes	No	Yes	Yes	5	0
241	7x49	7x50	Shared	4.89	3.26	No	Yes	Yes	Yes	9	9
242	Lig	Lig	Shared	437.12	467.453	Yes	Yes	Yes	Yes	0	0
243	1x36	2x65	Shared	3.53	1.1875	No	No	No	No	5	4
244	1x53	7x50	Shared	3.53	2.65	No	No	Yes	Yes	8	9
245	6x54	7x34	Shared	3.53	4.8425	No	No	No	No	4	4
246	6x50	7x37	Shared	3.5	5.6825	No	No	No	No	9	6
247	6x30	I3	Shared	3.49	2.86	No	Yes	Yes	No	7	4
248	3x47	5x57	Shared	3.44	4.3	No	No	No	No	9	6
249	1x58	2x44	Shared	3.42	2.12	No	No	No	No	2	5
250	4x59	4x60	Shared	3.39	1.755	No	No	No	No	3	8
251	1x38	7x39	Shared	3.25	6.975	No	No	No	No	5	4
252	5x48	5x52	Shared	2.94	1.6325	No	No	No	No	4	3
253	7x25	7x29	Shared	2.82	3.275	No	No	No	No	3	2
254	6x40	7x52	Shared	2.77	2.3075	No	No	No	No	7	7
255	2x45	3x42	Shared	2.65	7.33	Yes	No	No	Yes	9	7
256	1x43	2x54	Shared	2.62	4.6275	No	Yes	Yes	No	6	6
257	5x41	5x45	Shared	2.49	5.0825	No	No	No	No	4	4
258	2x59	3x24	Shared	2.44	7.29	No	No	No	Yes	6	5
259	3x24	E1x52	Shared	2.44	3.045	No	Yes	Yes	No	5	7
260	6x62	Lig	Shared	2.43	3.61	No	No	Yes	Yes	3	0
261	2x65	2x66	Shared	1.7	3.9725	No	No	No	No	4	5
262	6x49	6x50	Shared	1.64	3.3925	No	No	No	No	5	9
263	1x54	2x48	Shared	1.54	2.1575	No	No	No	No	7	5
264	1x37	1x41	Shared	1.52	1.07	No	No	No	No	4	4
265	3x34	4x54	Shared	1.49	4.07	No	No	No	No	5	3
266	6x30	6x32	Shared	1.44	1.435	No	Yes	Yes	No	7	8
267	5x61	5x65	Shared	1.43	2.1625	No	No	No	No	8	8
268	6x63	E3	Shared	1.43	0.7925	No	No	Yes	Yes	1	3
269	6x64	E3	Shared	1.35	1.9925	No	No	Yes	Yes	2	3
270	1x55	1x59	Shared	1.17	3.225	No	No	No	No	4	5
271	7x28	NT	chemokine_on	0	5.73	No	No	Yes	Yes	3	4
272	1x30	1x33	chemokine_on	0	3.315	Yes	No	No	No	4	5
273	1x31	7x32	chemokine_on	0	6.025	No	No	No	No	3	2
274	1x39	2x57	chemokine_on	0	4.1025	Yes	Yes	No	Yes	7	8
275	1x42	7x47	chemokine_on	0	3.31	No	No	No	No	7	7
276	1x43	1x47	chemokine_on	0	7.005	No	Yes	No	Yes	6	5
277	1x46	1x50	chemokine_on	0	3.83	No	No	No	Yes	8	9
278	1x52	8x54	chemokine_on	0	4.9825	No	No	No	No	5	0
279	1x53	8x50	chemokine_on	0	3.93	No	No	No	Yes	8	0
280	1x56	8x50	chemokine_on	0	3.9325	No	No	No	Yes	7	0
281	1x59	8x57	chemokine_on	0	5.1375	No	No	No	No	5	0
282	2x38	3x49	chemokine_on	0	5.475	No	No	No	No	6	8
283	2x38	4x42	chemokine_on	0	3.7275	No	No	No	No	6	7
284	2x42	4x42	chemokine_on	0	4.605	Yes	Yes	No	No	7	7
285	2x42	4x45	chemokine_on	0	4.86	Yes	Yes	No	No	7	5
286	2x46	3x39	chemokine_on	0	3.105	No	Yes	No	No	9	9
287	2x46	3x43	chemokine_on	0	3.46	No	Yes	No	No	9	8
288	2x49	4x50	chemokine_on	0	3.765	No	No	No	Yes	8	9
289	2x50	7x49	chemokine_on	0	4.7125	No	No	No	Yes	9	9
290	2x52	3x35	chemokine_on	0	4.1125	No	No	No	No	7	8
291	2x53	7x46	chemokine_on	0	8.305	Yes	Yes	No	No	7	9
292	2x56	3x32	chemokine_on	0	3.8225	No	No	Yes	Yes	6	6
293	2x57	7x42	chemokine_on	0	11.2225	No	Yes	Yes	Yes	8	7
294	3x25	E2	chemokine_on	0	5.905	No	No	Yes	Yes	9	3
295	3x32	3x33	chemokine_on	0	5.38	Yes	Yes	No	Yes	6	5
296	3x33	3x36	chemokine_on	0	3.205	No	Yes	No	Yes	5	7
297	3x36	3x37	chemokine_on	0	6.5675	No	Yes	No	Yes	7	7
298	3x36	3x40	chemokine_on	0	5.025	No	Yes	No	Yes	7	7
299	3x36	6x48	chemokine_on	0	11.0275	No	Yes	Yes	Yes	7	9
300	3x37	4x61	chemokine_on	0	6.37	No	Yes	No	Yes	7	4
301	3x38	4x53	chemokine_on	0	4.235	No	No	No	No	7	7
302	3x40	6x48	chemokine_on	0	4.6975	No	Yes	Yes	Yes	7	9
303	3x42	4x49	chemokine_on	0	5.8375	No	Yes	No	No	7	7
304	3x42	4x50	chemokine_on	0	8.305	No	Yes	No	Yes	7	9
305	3x43	7x53	chemokine_on	0	4.9825	No	No	No	Yes	8	9
306	3x44	5x50	chemokine_on	0	3.1525	No	No	No	No	7	9
307	3x46	3x50	chemokine_on	0	3.13	No	No	Yes	No	8	9
308	3x47	5x58	chemokine_on	0	10.4925	No	No	No	Yes	9	8
309	3x50	5x58	chemokine_on	0	4.63	Yes	No	No	Yes	9	8
310	3x51	5x57	chemokine_on	0	5.38	Yes	Yes	No	No	8	6
311	3x54	5x61	chemokine_on	0	8.165	No	No	No	No	8	8
312	4x41	4x45	chemokine_on	0	3.6875	No	No	No	No	3	5
313	4x65	E2x50	chemokine_on	0	5.52	No	No	No	No	4	9
314	4x65	E2x52	chemokine_on	0	6.105	No	No	Yes	No	4	5
315	5x36	E2x51	chemokine_on	0	6.945	No	No	No	No	4	3
316	5x32	E2	chemokine_on	0	7.5925	No	No	Yes	Yes	0	3
317	5x31	5x34	chemokine_on	0	4.8375	No	No	No	No	0	2
318	5x31	5x35	chemokine_on	0	12.5125	No	No	No	No	0	5
319	5x37	6x59	chemokine_on	0	3.43	No	No	No	No	3	5
320	5x37	6x62	chemokine_on	0	4.3425	No	No	No	No	3	3
321	5x40	6x55	chemokine_on	0	9.2075	No	No	No	No	5	5
322	5x40	6x58	chemokine_on	0	10.445	No	No	No	Yes	5	5
323	5x40	6x59	chemokine_on	0	6.65	No	No	No	No	5	5
324	5x44	6x52	chemokine_on	0	6.275	No	No	No	No	5	8
325	5x47	5x51	chemokine_on	0	3.9575	No	Yes	No	No	8	6
326	5x47	6x45	chemokine_on	0	3.52	No	Yes	No	No	8	4
327	5x47	6x49	chemokine_on	0	4.035	No	Yes	No	No	8	5
328	5x49	5x50	chemokine_on	0	4.23	No	No	No	No	6	9
329	5x51	6x45	chemokine_on	0	7.2925	No	No	No	No	6	4
330	5x54	6x44	chemokine_on	0	3.11	No	Yes	Yes	Yes	7	9
331	5x56	5x60	chemokine_on	0	8.8075	No	No	No	No	3	4
332	5x58	6x37	chemokine_on	0	7.855	No	Yes	No	No	8	7
333	5x58	6x41	chemokine_on	0	5.6775	No	Yes	No	No	8	7
334	5x68	I3	chemokine_on	0	7.1675	No	No	Yes	No	0	4
335	6x36	7x56	chemokine_on	0	5.0525	No	No	No	No	7	0
336	6x40	7x53	chemokine_on	0	5.365	No	No	No	Yes	7	9
337	6x43	7x45	chemokine_on	0	4.4275	No	No	Yes	No	6	9
338	6x47	7x45	chemokine_on	0	17.435	No	No	Yes	No	8	9
339	6x56	6x60	chemokine_on	0	3.1275	No	No	No	No	5	4
340	6x58	6x62	chemokine_on	0	3.275	No	Yes	No	No	5	3
341	6x61	E3	chemokine_on	0	4.2675	No	No	Yes	Yes	3	3
342	7x23	7x26	chemokine_on	0	5.5775	No	No	No	No	5	1
343	7x34	Lig	chemokine_on	0	5.54	No	No	Yes	Yes	4	0
344	7x40	7x43	chemokine_on	0	3.345	No	No	Yes	No	7	5
345	7x49	7x53	chemokine_on	0	5.815	No	Yes	No	Yes	9	9
346	7x54	8x50	chemokine_on	0	4.1575	No	No	No	Yes	7	0
347	8x56	8x57	chemokine_on	0	3.5775	No	No	No	No	0	0
348	1x56	8x53	chemokine_on	0	4.465	No	No	No	No	7	0
349	2x60	3x28	chemokine_on	0	6.6775	Yes	Yes	No	No	7	5
350	2x60	3x29	chemokine_on	0	5.1725	Yes	Yes	Yes	No	7	6
351	2x64	Lig	chemokine_on	0	4.085	No	No	Yes	Yes	5	0
352	3x34	3x35	chemokine_on	0	3.6125	No	No	No	No	5	8
353	4x41	4x44	chemokine_on	0	4.49	No	No	No	No	3	2
354	5x31	E2	chemokine_on	0	4.4175	No	No	Yes	Yes	0	3
355	5x54	6x41	chemokine_on	0	4.565	No	Yes	No	No	7	7
356	6x58	6x59	chemokine_on	0	3.905	No	Yes	No	No	5	5
357	7x48	7x51	chemokine_on	0	4.1525	No	No	No	No	6	6
358	8x48	8x52	chemokine_on	0	5.1075	No	No	No	No	0	0
359	1x38	1x42	chemokine_on	0	5.025	No	No	No	No	5	7
360	1x47	1x51	chemokine_on	0	4.15	No	Yes	No	No	5	3
361	2x40	I1x49	chemokine_on	0	4.84	No	No	No	No	8	0
362	2x62	2x66	chemokine_on	0	4.465	No	No	No	No	5	5
363	2x63	E1	chemokine_on	0	3.935	No	No	No	Yes	5	0
364	2x63	3x24	chemokine_on	0	4.79	No	No	No	Yes	5	5
365	2x66	E1	chemokine_on	0	6.295	No	No	No	Yes	5	0
366	E1	E2	chemokine_on	0	11.73	No	Yes	Yes	Yes	0	3
367	3x24	E1	chemokine_on	0	6.36	No	Yes	No	Yes	5	0
368	3x26	E2	chemokine_on	0	3.51	No	No	Yes	Yes	7	3
369	3x27	3x31	chemokine_on	0	5.36	No	No	No	No	4	5
370	3x32	Lig	chemokine_on	0	10.18	Yes	Yes	Yes	Yes	6	0
371	3x33	Lig	chemokine_on	0	5.1	No	Yes	Yes	Yes	5	0
372	I2x52	I2x56	chemokine_on	0	3.405	No	Yes	No	No	5	4
373	4x60	5x42	chemokine_on	0	3.145	No	No	No	No	8	3
374	4x61	5x39	chemokine_on	0	4.675	No	Yes	No	No	4	5
375	5x38	5x42	chemokine_on	0	7.29	No	No	No	No	3	3
376	5x39	Lig	chemokine_on	0	8.97	No	No	Yes	Yes	5	0
377	5x54	6x45	chemokine_on	0	3.11	No	Yes	No	No	7	4
378	5x58	6x38	chemokine_on	0	4.69	No	Yes	No	No	8	4
379	5x59	5x63	chemokine_on	0	7.025	No	No	No	No	3	4
380	5x61	6x34	chemokine_on	0	4.415	No	No	No	No	8	5
381	5x62	5x66	chemokine_on	0	3.77	No	No	No	No	4	4
382	6x29	6x30	chemokine_on	0	4.31	No	No	No	Yes	0	7
383	6x55	6x58	chemokine_on	0	3.415	No	No	No	Yes	5	5
384	6x57	E3	chemokine_on	0	6.695	No	No	Yes	Yes	5	3
385	8x50	8x54	chemokine_on	0	3.655	No	Yes	No	No	0	0
386	8x51	8x55	chemokine_on	0	5.145	No	No	No	No	0	0
387	3x56	I2x53	chemokine_on	0	3.08	No	Yes	No	No	6	5
388	1x52	7x55	chemokine_on	0	3.045	No	No	No	No	5	0
389	3x54	5x64	chemokine_on	0	3.04	No	No	No	No	8	4
390	4x39	I1x51	chemokine_on	0	3.035	No	No	No	No	4	0
391	3x52	3x56	chemokine_on	0	2.9925	No	No	No	Yes	5	6
392	1x32	2x64	chemokine_on	0	2.95	No	No	No	No	4	5
393	8x53	8x57	chemokine_on	0	2.93	No	No	No	No	0	0
394	I2x52	I2x55	chemokine_on	0	2.91	No	Yes	No	No	5	5
395	I2x51	I2x52	chemokine_on	0	2.91	No	No	No	Yes	5	5
396	7x23	7x25	chemokine_on	0	2.89	No	No	No	No	5	3
397	4x56	5x46	chemokine_on	0	2.875	No	No	No	No	5	4
398	6x61	Lig	chemokine_on	0	2.875	No	No	Yes	Yes	3	0
399	3x34	4x57	chemokine_on	0	2.8575	No	No	No	No	5	6
400	5x62	6x37	chemokine_on	0	2.855	No	No	No	No	4	7
401	7x48	7x52	chemokine_on	0	2.855	No	No	No	No	6	7
402	E1x51	E1x52	chemokine_on	0	2.8275	No	No	Yes	No	3	7
403	1x57	2x43	chemokine_on	0	2.77	No	No	No	No	6	8
404	1x50	2x51	chemokine_on	0	2.745	No	Yes	No	No	9	7
405	3x56	I2x52	chemokine_on	0	2.66	No	Yes	No	Yes	6	5
406	1x38	7x43	chemokine_on	0	2.64	No	No	Yes	No	5	5
407	7x32	NT	chemokine_on	0	2.635	No	No	Yes	Yes	2	4
408	3x48	5x57	chemokine_on	0	2.49	No	No	No	No	6	6
409	I2x54	I2x55	chemokine_on	0	2.4725	No	No	No	No	5	5
410	7x30	E3	chemokine_on	0	2.435	No	No	Yes	Yes	5	3
411	3x41	4x52	chemokine_on	0	2.425	Yes	No	No	No	5	4
412	1x32	1x33	chemokine_on	0	2.3875	No	No	No	No	4	5
413	5x65	6x31	chemokine_on	0	2.365	No	No	No	No	8	5
414	1x29	1x34	chemokine_on	0	2.3325	No	No	No	No	3	5
415	1x24	1x28	chemokine_on	0	2.305	Yes	No	No	No	5	1
416	6x31	6x35	chemokine_on	0	2.2575	No	No	No	No	5	6
417	5x55	6x41	chemokine_on	0	2.235	No	No	No	No	4	7
418	5x45	5x46	chemokine_on	0	2.2325	No	No	No	No	4	4
419	6x54	7x33	chemokine_on	0	2.1225	No	No	No	No	4	6
420	2x48	2x52	chemokine_on	0	2.075	No	No	No	No	5	7
421	2x64	7x35	chemokine_on	0	2.075	No	No	No	No	5	5
422	2x44	2x48	chemokine_on	0	2.075	No	No	No	No	5	5
423	5x33	5x34	chemokine_on	0	2.05	No	No	No	No	1	2
424	2x41	4x42	chemokine_on	0	2.005	No	No	No	No	6	7
425	6x30	6x31	chemokine_on	0	1.965	No	Yes	No	No	7	5
426	1x59	8x61	chemokine_on	0	1.905	No	No	No	No	5	0
427	7x56	8x47	chemokine_on	0	1.855	No	No	No	No	0	0
428	1x43	2x57	chemokine_on	0	1.8275	No	Yes	No	Yes	6	8
429	5x49	5x53	chemokine_on	0	1.825	No	No	No	No	6	6
430	1x48	1x49	chemokine_on	0	1.775	No	No	No	No	4	8
431	4x59	4x62	chemokine_on	0	1.73	No	No	No	No	3	4
432	7x35	7x36	chemokine_on	0	1.615	No	No	No	No	5	6
433	6x53	6x54	chemokine_on	0	1.605	No	No	No	No	6	4
434	6x32	8x51	chemokine_on	0	1.6	Yes	No	No	No	8	0
435	1x29	1x33	chemokine_on	0	1.56	No	No	No	No	3	5
436	1x37	1x40	chemokine_on	0	1.55	No	No	No	No	4	5
437	1x41	1x42	chemokine_on	0	1.515	No	No	No	No	4	7
438	6x32	8x48	chemokine_on	0	1.46	Yes	No	No	No	8	0
439	4x40	4x43	chemokine_on	0	1.435	No	No	No	No	4	3
440	6x36	6x37	chemokine_on	0	1.425	No	No	No	No	7	7
441	5x60	5x63	chemokine_on	0	1.3875	No	No	No	No	4	4
442	I2x52	I2x58	chemokine_on	0	1.3325	No	Yes	No	No	5	0
443	8x60	8x61	chemokine_on	0	1.325	No	No	No	No	0	0
444	I1x49	I1x50	chemokine_on	0	1.295	No	No	No	No	0	0
445	6x39	7x52	chemokine_on	0	1.2175	No	No	No	No	5	7
446	2x37	2x39	chemokine_on	0	1.2	No	No	No	No	7	7
447	5x66	6x28	chemokine_on	0	1.13	No	No	No	No	4	0
448	6x42	6x43	chemokine_on	0	1.1275	No	No	No	No	5	6
449	6x46	6x47	chemokine_on	0	1.0075	No	No	No	No	5	8
450	4x48	4x51	chemokine_on	0	0.975	No	No	No	No	3	4
451	I2x50	I2x53	chemokine_on	0	0.855	No	No	No	No	8	5
452	4x47	4x48	chemokine_on	0	0.855	No	No	No	No	4	3
453	I1x50	I1x51	chemokine_on	0	0.835	No	No	No	No	0	0
454	5x65	6x33	chemokine_on	0	0.79	No	No	No	No	8	7
455	3x21	E1x52	chemokine_on	0	0.755	No	No	Yes	No	8	7
456	1x60	2x40	chemokine_on	0	0.735	No	No	No	No	4	8
457	4x38	4x40	chemokine_on	0	0.71	No	No	No	No	6	4
458	4x50	4x51	chemokine_on	0	0.705	No	Yes	No	No	9	4
459	4x55	4x56	chemokine_on	0	0.6925	No	No	No	No	4	5
460	8x54	8x58	chemokine_on	0	0.6925	No	No	No	No	0	0
461	3x23	3x27	chemokine_on	0	0.655	No	No	No	No	1	4
462	8x49	8x50	chemokine_on	0	0.62	No	No	No	Yes	0	0
463	1x47	2x55	chemokine_on	0	0.345	No	Yes	No	No	5	4
464	1x44	1x47	chemokine_on	0	0.345	No	No	No	Yes	5	5
465	2x52	2x55	chemokine_on	0	0.345	No	No	No	No	7	4
466	4x41	I2x59	chemokine_on	0	0.2925	No	No	No	No	3	0

Orange: nodes, hubs and links specific of chemokine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of chemokine_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	chemokine_off Avg Int. Strength	chemokine_on Avg Int. Strength	chemokine_off Num Of Links	chemokine_on Num Of Links	ConSurf
1	1x24	chemokine_off	11	3.0825	4	2	5
2	1x26	chemokine_off	7.515	0	4	0	4
3	1x27	chemokine_off	8.3475	5.815	4	1	6
4	1x30	chemokine_off	8.8125	3.315	4	1	4
5	2x45	chemokine_off	6.14	6.96333	4	3	9
6	2x54	chemokine_off	3.4725	4.6275	4	1	6
7	E1x50	chemokine_off	7.43857	3.52667	7	3	9
8	E1x52	chemokine_off	9.1875	2.20917	4	3	7
9	3x29	chemokine_off	6.145	6.50125	4	2	6
10	3x41	chemokine_off	5.948	2.7825	5	2	5
11	3x45	chemokine_off	4.798	4.5	5	1	5
12	3x50	chemokine_off	5.4125	3.665	4	3	9
13	I2x57	chemokine_off	6.145	5.9575	6	3	6
14	E2x52	chemokine_off	9.8325	4.69583	4	3	5
15	I3	chemokine_off	3.55	5.01375	4	2	4
16	6x32	chemokine_off	2.2925	1.49833	4	3	8
17	7x38	chemokine_off	9.0725	7.54333	4	3	5
18	7x43	chemokine_off	3.6475	2.9925	4	2	5
19	7x45	chemokine_off	7.2125	8.9625	4	3	9
20	NT	Shared	18.1617	11.4479	6	7	4
21	1x39	Shared	5.11	8.1735	5	5	7
22	2x42	Shared	6.0875	4.686	4	5	7
23	2x53	Shared	7.982	6.5585	5	5	7
24	2x60	Shared	8.935	6.8	6	4	7
25	3x32	Shared	8.8	6.3375	4	5	6
26	3x51	Shared	6.07	6.5075	5	4	8
27	E2	Shared	17.9014	12.0488	14	15	3
28	6x44	Shared	6.465	5.83125	6	4	9
29	6x48	Shared	7.1	7.21042	5	6	9
30	6x51	Shared	8.125	5.82313	4	4	7
31	E3	Shared	6.35429	7.49528	7	9	3
32	7x42	Shared	7.164	11.0662	5	4	7
33	7x50	Shared	5.97	3.74125	4	4	9
34	Lig	Shared	69.0794	61.9068	16	18	0
35	1x43	chemokine_on	4.92	5.71187	2	4	6
36	1x47	chemokine_on	3.075	2.96125	2	4	5
37	1x50	chemokine_on	12.43	6.05	2	4	9
38	2x46	chemokine_on	6.975	4.095	2	4	9
39	2x57	chemokine_on	3.925	5.81063	2	4	8
40	3x24	chemokine_on	2.03333	5.37125	3	4	5
41	3x33	chemokine_on	7.35	5.80813	2	4	5
42	3x36	chemokine_on	9.38	6.45625	1	4	7
43	3x37	chemokine_on	7.01667	6.52313	3	4	7
44	3x40	chemokine_on	4.89333	4.3925	3	4	7
45	3x42	chemokine_on	4.18	6.19187	2	4	7
46	3x56	chemokine_on	10.98	3.5755	2	5	6
47	I2x52	chemokine_on	0	2.6435	0	5	5
48	4x50	chemokine_on	7.13	4.9365	3	5	9
49	4x61	chemokine_on	10.32	5.97437	3	4	4
50	5x47	chemokine_on	8.21	6.3525	1	4	8
51	5x54	chemokine_on	6.27	3.94188	2	4	7
52	5x58	chemokine_on	8.46	6.669	1	5	8
53	6x30	chemokine_on	2.465	2.6425	2	4	7
54	6x58	chemokine_on	8.14333	5.041	3	5	5
55	7x49	chemokine_on	7.19	5.07688	3	4	9
56	7x53	chemokine_on	17.49	5.06563	1	4	9
57	8x50	chemokine_on	0	3.259	0	5	0
58	E1	chemokine_on	0	7.08	0	4	0

Orange: nodes, hubs and links specific of chemokine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of chemokine_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	chemokine_off Recurrence	chemokine_on Recurrence	chemokine_off Hub1?	chemokine_on Hub1?	chemokine_off Hub2?	chemokine_on Hub2?	ConSurf1	ConSurf2
1	1x27	7x31	chemokine_off	13.5392	0	Yes	No	No	No	6	4
2	7x31	Lig	chemokine_off	22.7106	1.16098	No	No	Yes	Yes	4	0
3	1x30	1x31	chemokine_off	17.8787	0	Yes	No	No	No	4	3
4	1x30	1x34	chemokine_off	11.4292	0	Yes	No	No	No	4	5
5	1x35	1x39	chemokine_off	23.3999	1.01311	No	No	Yes	Yes	6	7
6	1x39	2x60	chemokine_off	22.6403	0	Yes	Yes	Yes	Yes	7	7
7	2x60	Lig	chemokine_off	29.0477	3.87459	Yes	Yes	Yes	Yes	7	0
8	1x39	7x39	chemokine_off	11.387	9.96923	Yes	Yes	No	No	7	4
9	7x43	7x48	chemokine_off	15.5226	0	Yes	No	No	No	5	6
10	6x40	7x48	chemokine_off	19.2643	0	No	No	No	No	7	6
11	3x43	6x40	chemokine_off	35.3988	0	No	No	No	No	8	7
12	2x54	2x57	chemokine_off	12.3505	0	Yes	No	No	Yes	6	8
13	2x53	2x57	chemokine_off	14.0596	5.67101	Yes	Yes	No	Yes	7	8
14	2x53	2x60	chemokine_off	34.6533	0	Yes	Yes	Yes	Yes	7	7
15	1x50	7x50	chemokine_off	55.6407	7.37351	No	Yes	Yes	Yes	9	9
16	1x50	2x50	chemokine_off	57.596	8.27272	No	Yes	No	No	9	9
17	7x45	7x46	chemokine_off	61.4643	0	Yes	No	No	No	9	9
18	3x35	7x45	chemokine_off	47.7282	0	No	No	Yes	No	8	9
19	6x48	7x45	chemokine_off	21.8526	4.44409	Yes	Yes	Yes	No	9	9
20	1x53	2x47	chemokine_off	11.4573	1.29286	No	No	No	No	8	9
21	2x40	2x43	chemokine_off	11.4573	0	No	No	No	No	8	8
22	2x43	7x49	chemokine_off	15.8109	0	No	No	No	Yes	8	9
23	3x49	I2x57	chemokine_off	46.624	3.87459	No	No	Yes	No	8	6
24	2x42	3x49	chemokine_off	51.7724	7.73719	Yes	Yes	No	No	7	8
25	2x42	3x45	chemokine_off	58.1376	1.94429	Yes	Yes	Yes	No	7	5
26	3x45	4x49	chemokine_off	68.5329	0	Yes	No	No	No	5	7
27	3x41	4x49	chemokine_off	69.9606	0	Yes	No	No	No	5	7
28	3x40	3x41	chemokine_off	86.4819	1.46871	No	Yes	Yes	No	7	5
29	2x45	3x42	chemokine_off	18.1671	2.28399	Yes	No	No	Yes	9	7
30	2x45	4x50	chemokine_off	11.4221	0.0259771	Yes	No	No	Yes	9	9
31	3x28	Lig	chemokine_off	14.0385	0	No	No	Yes	Yes	5	0
32	E1x50	Lig	chemokine_off	12.8851	0	Yes	No	Yes	Yes	9	0
33	E1x49	E1x51	chemokine_off	11.1338	0	No	No	No	No	4	3
34	E1x49	E2	chemokine_off	12.8499	1.09903	No	No	Yes	Yes	4	3
35	3x29	Lig	chemokine_off	16.6549	0	Yes	No	Yes	Yes	6	0
36	6x48	6x52	chemokine_off	12.4701	0	Yes	Yes	No	No	9	8
37	3x41	3x44	chemokine_off	11.7246	0	Yes	No	No	No	5	7
38	3x51	3x52	chemokine_off	13.5321	0	Yes	Yes	No	No	8	5
39	3x52	I2x57	chemokine_off	20.8538	0	No	No	Yes	No	5	6
40	3x53	I2x57	chemokine_off	15.3678	1.94429	No	No	Yes	No	8	6
41	3x41	5x49	chemokine_off	11.7246	0	Yes	No	No	No	5	6
42	3x53	6x32	chemokine_off	13.4829	0	No	No	Yes	No	8	8
43	6x36	7x52	chemokine_off	13.6306	0	No	No	No	No	7	7
44	6x40	7x52	chemokine_off	15.5226	4.64192	No	No	No	No	7	7
45	6x58	Lig	chemokine_off	21.8244	1.33083	No	Yes	Yes	Yes	5	0
46	6x61	7x26	chemokine_off	11.2182	0	No	No	No	No	3	1
47	6x61	7x30	chemokine_off	13.0398	0	No	No	No	No	3	5
48	6x58	7x30	chemokine_off	16.6409	0	No	Yes	No	No	5	5
49	1x31	1x35	chemokine_off	16.2681	0	No	No	No	No	3	6
50	1x39	7x42	chemokine_off	18.8282	9.6615	Yes	Yes	Yes	Yes	7	7
51	6x44	7x45	chemokine_off	38.7115	0	Yes	Yes	Yes	No	9	9
52	2x53	7x42	chemokine_off	11.6331	6.96187	Yes	Yes	Yes	Yes	7	7
53	7x38	7x42	Shared	10.4515	14.0257	Yes	No	Yes	Yes	5	7
54	7x38	Lig	Shared	80.806	24.1947	Yes	No	Yes	Yes	5	0
55	3x43	6x44	Shared	38.7537	34.7194	No	No	Yes	Yes	8	9
56	6x44	6x48	Shared	76.6493	62.9886	Yes	Yes	Yes	Yes	9	9
57	6x48	6x51	Shared	98.9309	32.2476	Yes	Yes	Yes	Yes	9	7
58	6x51	7x38	Shared	100	30.3653	Yes	Yes	Yes	No	7	5
59	2x50	7x46	Shared	59.5372	18.3499	No	No	No	No	9	9
60	2x53	3x35	Shared	47.679	15.5623	Yes	Yes	No	No	7	8
61	1x53	7x50	Shared	13.708	20.8856	No	No	Yes	Yes	8	9
62	7x49	7x50	Shared	39.4922	20.6318	No	Yes	Yes	Yes	9	9
63	3x40	6x44	Shared	90.8145	31.4084	No	Yes	Yes	Yes	7	9
64	2x46	3x42	Shared	20.3756	12.527	No	Yes	No	Yes	9	7
65	2x46	7x49	Shared	22.57	13.1245	No	Yes	No	Yes	9	9
66	E2	Lig	Shared	38.0926	27.0682	Yes	Yes	Yes	Yes	3	0
67	2x64	Lig	chemokine_on	0	10.3289	No	No	Yes	Yes	5	0
68	2x53	3x32	chemokine_on	1.82163	25.5016	Yes	Yes	Yes	Yes	7	6
69	3x32	Lig	chemokine_on	0	12.7008	Yes	Yes	Yes	Yes	6	0
70	2x53	7x46	chemokine_on	0	18.1141	Yes	Yes	No	No	7	9
71	2x50	7x49	chemokine_on	0	13.8518	No	No	No	Yes	9	9
72	1x53	8x50	chemokine_on	0	18.4178	No	No	No	Yes	8	0
73	2x37	2x39	chemokine_on	0	13.2044	No	No	No	No	7	7
74	2x39	3x50	chemokine_on	1.96933	14.781	No	No	Yes	No	7	9
75	3x50	5x58	chemokine_on	0	47.4682	Yes	No	No	Yes	9	8
76	3x47	5x58	chemokine_on	0	33.0609	No	No	No	Yes	9	8
77	3x47	5x54	chemokine_on	3.95977	66.5474	No	No	No	Yes	9	7
78	5x54	6x44	chemokine_on	0	100	No	Yes	Yes	Yes	7	9
79	3x36	3x40	chemokine_on	0	30.9468	No	Yes	No	Yes	7	7
80	3x33	3x36	chemokine_on	0	54.9237	No	Yes	No	Yes	5	7
81	3x33	Lig	chemokine_on	0	39.5952	No	Yes	Yes	Yes	5	0
82	5x58	6x41	chemokine_on	0	30.3953	No	Yes	No	No	8	7
83	5x54	6x41	chemokine_on	0	32.0698	No	Yes	No	No	7	7
84	3x36	6x48	chemokine_on	0	32.3156	No	Yes	Yes	Yes	7	9
85	2x37	2x40	chemokine_on	2.31397	11.2801	No	No	No	No	7	8
86	2x42	3x46	chemokine_on	3.69954	29.6539	Yes	Yes	No	No	7	8
87	3x46	3x50	chemokine_on	0	31.5382	No	No	Yes	No	8	9
88	2x42	4x45	chemokine_on	0	12.509	Yes	Yes	No	No	7	5
89	2x46	3x43	chemokine_on	0	18.8394	No	Yes	No	No	9	8
90	E1	E2	chemokine_on	0	11.5019	No	Yes	Yes	Yes	0	3
91	3x34	3x35	chemokine_on	0	10.8245	No	No	No	No	5	8
92	3x36	3x37	chemokine_on	0	12.485	No	Yes	No	Yes	7	7
93	3x37	4x56	chemokine_on	3.6503	10.9364	No	Yes	No	No	7	5
94	3x47	5x57	chemokine_on	1.9834	38.5521	No	No	No	No	9	6
95	3x51	5x57	chemokine_on	0	32.1737	Yes	Yes	No	No	8	6
96	3x51	3x55	chemokine_on	4.01604	17.6724	Yes	Yes	No	No	8	7
97	3x54	5x64	chemokine_on	0	16.0499	No	No	No	No	8	4
98	3x55	5x64	chemokine_on	2.01857	17.041	No	No	No	No	7	4
99	3x54	5x61	chemokine_on	0	15.0548	No	No	No	No	8	8
100	4x41	4x45	chemokine_on	0	10.5847	No	No	No	No	3	5
101	5x58	6x37	chemokine_on	0	12.6848	No	Yes	No	No	8	7
102	5x65	6x31	chemokine_on	0	11.0343	No	No	No	No	8	5
103	5x61	5x65	chemokine_on	2.22253	13.0525	No	No	No	No	8	8
104	3x43	7x53	chemokine_on	0	15.864	No	No	No	Yes	8	9
105	7x49	7x53	chemokine_on	0	11.2561	No	Yes	No	Yes	9	9
106	6x61	E3	chemokine_on	0	14.3514	No	No	Yes	Yes	3	3
107	6x61	Lig	chemokine_on	0	15.4684	No	No	Yes	Yes	3	0
108	3x32	3x33	chemokine_on	0	14.9189	Yes	Yes	No	Yes	6	5

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
Lig	NT	Shared	62.43	30.57	1	1	0	1
NT	NT	Shared	10.09	18.055	1	1	1	1
1x24	NT	chemokine_off	9.75	0	1	1	1	1
7x24	NT	Shared	7.28	3.64	0	0	2	1
1x25	NT	Shared	9.33	1.45	0	0	2	1
1x24	7x27	chemokine_off	9.3	0	1	1	1	1
1x24	7x28	chemokine_off	7.23	0	1	1	1	2
1x24	Lig	Shared	17.72	3.86	1	1	1	0
1x27	7x28	Shared	12.26	5.815	1	0	2	2
1x27	7x31	chemokine_off	10.2	0	1	0	2	1
1x27	7x32	chemokine_off	6.99	0	1	0	2	2
1x35	1x39	Shared	5.86	7.7525	0	0	2	2
1x39	2x60	chemokine_off	3.86	0	1	1	2	1
1x39	7x42	Shared	5.16	20.8075	1	1	2	2
2x53	2x60	chemokine_off	6.01	0	1	1	2	1
2x53	3x32	Shared	5.16	6.005	1	1	2	1
2x53	7x42	Shared	11.79	7.8625	1	1	2	2
2x56	3x28	Shared	4.76	3.1475	0	0	2	1
2x59	E1x52	chemokine_off	10.72	0	1	0	2	2
2x59	3x28	Shared	3.93	8.6725	1	0	2	1
2x60	3x32	Shared	14.47	6.3	1	1	1	1
2x60	7x38	chemokine_off	8.72	0	1	1	1	1
2x60	7x42	chemokine_off	8.02	0	1	1	1	2
2x60	Lig	Shared	12.53	9.05	1	1	1	0
2x63	E1x50	Shared	4.47	3.3975	1	1	1	1
2x63	E2	chemokine_off	4.76	0	1	1	1	1
2x63	Lig	chemokine_off	16.86	0	1	1	1	0
E1x49	E2	Shared	21.4	1.855	1	0	2	1
E1x50	E1x52	chemokine_off	17.04	0	1	1	1	2
3x25	E1x50	Shared	3.92	3.265	1	1	2	1
E1x50	E2	chemokine_off	4.9	0	1	1	1	1
E1x50	E2x50	Shared	14.37	3.9175	1	1	1	2
E1x50	Lig	chemokine_off	4.56	0	1	1	1	0
3x22	3x26	chemokine_off	4.2	0	1	0	2	2
3x22	E2	Shared	10	3.165	1	0	2	1
3x25	E2x50	Shared	7.28	7.28	1	1	2	2
3x28	Lig	chemokine_off	4.47	0	1	0	1	0
3x29	4x61	chemokine_off	6.3	0	1	0	1	2
3x29	4x65	Shared	8.78	7.83	1	0	1	2
3x29	E2x52	chemokine_off	5.64	0	1	0	1	2
3x29	Lig	chemokine_off	3.86	0	1	0	1	0
3x32	3x36	chemokine_off	9.38	0	1	1	1	2
3x32	7x42	chemokine_off	6.19	0	1	1	1	2
3x33	4x61	Shared	11.56	9.5475	0	1	1	2
4x60	E2x52	chemokine_off	7.21	0	0	0	2	2
4x60	5x39	chemokine_off	7.22	0	0	0	2	1
4x61	E2x52	Shared	13.1	3.305	1	0	2	2
4x64	E2	Shared	14.24	8.66	1	1	2	1
4x64	5x35	Shared	5.01	5.01	1	1	2	2
E2	E2	Shared	43.15	34.31	1	1	1	1
E2	Lig	Shared	37.32	40.86	1	1	1	0
E2	E2x51	Shared	11.89	5.26	1	1	1	1
E2x51	Lig	Shared	7.28	12.8525	1	1	1	0
E2	E2x52	Shared	13.38	4.6775	1	1	1	2
5x35	E2	Shared	24.31	10.88	1	1	2	1
5x36	E2	chemokine_off	6.31	0	1	0	2	1
5x39	E2	Shared	10.32	3.6	1	1	1	1
5x34	E2	chemokine_off	5.49	0	0	0	2	1
6x51	6x55	Shared	6.04	6.245	0	0	2	2
6x51	7x38	Shared	13.47	5.3325	0	0	2	1
6x58	7x34	chemokine_off	4.2	0	1	1	1	1
6x58	Lig	Shared	17.31	4.165	1	1	1	0
6x61	7x26	chemokine_off	5.02	0	0	1	1	2
E3	E3	Shared	4.21	15.1375	9	1	2	2
7x26	E3	Shared	17.82	6.81	9	1	2	2
7x27	Lig	Shared	21.75	18.1525	1	0	1	0
7x31	7x35	chemokine_off	8.37	0	1	0	1	2
7x31	Lig	Shared	13.07	6.6225	1	0	1	0
7x38	7x42	Shared	4.66	4.3725	1	1	1	2
7x38	Lig	Shared	9.44	12.925	1	1	1	0
6x54	7x34	Shared	3.53	4.8425	0	0	2	1
3x33	4x57	chemokine_off	3.14	0	0	1	1	2
6x61	7x30	chemokine_off	3.07	0	0	1	1	2
6x58	7x30	chemokine_off	2.92	0	1	1	1	2
3x21	E1x50	chemokine_off	2.81	0	0	0	2	1
5x38	5x39	chemokine_off	2.62	0	0	0	2	1
2x59	3x24	Shared	2.44	7.29	1	0	2	2
3x24	E1x52	Shared	2.44	3.045	1	1	2	2
6x62	Lig	Shared	2.43	3.61	0	1	1	0
1x28	1x32	chemokine_off	1.61	0	0	0	2	2
1x35	2x64	chemokine_off	1.58	0	0	0	2	1
6x55	6x59	chemokine_off	1.55	0	0	1	2	2
5x36	5x40	chemokine_off	1.43	0	1	0	2	2
7x28	NT	chemokine_on	0	5.73	1	1	2	1
2x56	3x32	chemokine_on	0	3.8225	0	0	2	1
3x25	E2	chemokine_on	0	5.905	1	1	2	1
3x32	3x33	chemokine_on	0	5.38	1	1	1	1
3x33	3x36	chemokine_on	0	3.205	0	1	1	2
4x65	E2x50	chemokine_on	0	5.52	0	0	2	2
4x65	E2x52	chemokine_on	0	6.105	0	0	2	2
5x36	E2x51	chemokine_on	0	6.945	1	0	2	1
5x32	E2	chemokine_on	0	7.5925	0	0	2	1
5x31	5x34	chemokine_on	0	4.8375	0	1	2	2
5x31	5x35	chemokine_on	0	12.5125	0	1	2	2
5x37	6x59	chemokine_on	0	3.43	0	0	2	2
5x37	6x62	chemokine_on	0	4.3425	0	0	2	1
5x40	6x55	chemokine_on	0	9.2075	0	1	2	2
5x40	6x58	chemokine_on	0	10.445	0	1	2	1
5x40	6x59	chemokine_on	0	6.65	0	1	2	2
6x58	6x62	chemokine_on	0	3.275	1	1	1	1
6x61	E3	chemokine_on	0	4.2675	0	1	1	2
7x34	Lig	chemokine_on	0	5.54	0	1	1	0
2x60	3x28	chemokine_on	0	6.6775	1	1	1	1
2x60	3x29	chemokine_on	0	5.1725	1	1	1	1
2x64	Lig	chemokine_on	0	4.085	0	1	1	0
5x31	E2	chemokine_on	0	4.4175	0	1	2	1
6x58	6x59	chemokine_on	0	3.905	1	1	1	2
2x63	E1	chemokine_on	0	3.935	1	1	1	2
2x63	3x24	chemokine_on	0	4.79	1	1	1	2
E1	E2	chemokine_on	0	11.73	0	1	2	1
3x24	E1	chemokine_on	0	6.36	1	1	2	2
3x26	E2	chemokine_on	0	3.51	0	0	2	1
3x32	Lig	chemokine_on	0	10.18	1	1	1	0
3x33	Lig	chemokine_on	0	5.1	0	1	1	0
4x61	5x39	chemokine_on	0	4.675	1	0	2	1
5x39	Lig	chemokine_on	0	8.97	1	1	1	0
6x55	6x58	chemokine_on	0	3.415	0	1	2	1
1x32	2x64	chemokine_on	0	2.95	0	0	2	1
6x61	Lig	chemokine_on	0	2.875	0	1	1	0
7x32	NT	chemokine_on	0	2.635	1	1	2	1
7x30	E3	chemokine_on	0	2.435	0	0	2	2
1x24	1x28	chemokine_on	0	2.305	1	1	1	2
2x64	7x35	chemokine_on	0	2.075	0	1	1	2
3x21	E1x52	chemokine_on	0	0.755	0	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	chemokine_off	cxcr_off
	chemokine_on	cxcr_on cx3cr_on

Network Difference
Value	chemokine_off	chemokine_on
I_min	3.68	3.105
Number of Linked Nodes	232	277
Number of Specific Nodes	1 (0.43%)	46 (16.61%)
Number of Shared Nodes	231 (99.57%)	231 (83.39%)
Number of Links	270	319
Number of Specific Links	147 (54.44%)	196 (61.44%)
Number of Shared Links	123 (45.56%)	123 (38.56%)
Number of Hubs	34	39
Number of Specific Hubs	19 (55.88%)	24 (61.54%)
Number of Shared Hubs	15 (44.12%)	15 (38.46%)
Average % Shared Neighbours (Jaccard)	25.84
Average % Shared Neighbours (Otsuka)	33.78
Average % Shared Neighbours (Overlap Coefficient)	41.65
Average % Shared Cliques (k3-6)	52.27
Graphlets Similarity	0.579325

Paths Difference
Value	chemokine_off	chemokine_on
Number Of Nodes in MetaPath	63	51
Specific Nodes in MetaPath	41 (65.08%)	29 (56.86%)
Shared Nodes in MetaPath	231 (99.57%)	231 (99.57%)
Number Of Links MetaPath	66	56
Specific Links in MetaPath	52 (78.79%)	42 (75.00%)
Shared Links in MetaPath	123 (45.56%)	123 (45.56%)
Number of Shortest Paths	35141	87396
Length Of Smallest Path	3	3
Average Path Length	12.0647	12.6568
Length of Longest Path	26	28
Minimum Path Strength	1.39	0.345
Average Path Strength	7.65782	5.96673
Maximum Path Strength	41.3533	27.4367
Minimum Path Correlation	0.71	0.7
Average Path Correlation	0.95496	0.936184
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	6.25	4.54545
Average % Of Corr. Nodes	61.3693	49.811
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	47.2684	49.8875
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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