psnGPCR

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Orange: nodes, hubs and links specific of cxcr_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cxcr_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	cxcr_off Int. Strength	cxcr_on Int. Strength	cxcr_off Hub1?	cxcr_on Hub1?	cxcr_off Hub2?	cxcr_on Hub2?	ConSurf1	ConSurf2
1	1x24	NT	cxcr_off	9.75	0	Yes	No	Yes	Yes	5	4
2	1x25	NT	cxcr_off	9.33	0	No	No	Yes	Yes	5	4
3	1x24	7x27	cxcr_off	9.3	0	Yes	No	No	No	5	2
4	1x24	7x28	cxcr_off	7.23	0	Yes	No	No	No	5	3
5	1x24	Lig	cxcr_off	17.72	0	Yes	No	Yes	Yes	5	0
6	1x26	1x27	cxcr_off	3.94	0	Yes	No	Yes	No	4	6
7	1x26	7x25	cxcr_off	7.61	0	Yes	No	No	No	4	3
8	1x26	7x28	cxcr_off	14.46	0	Yes	No	No	No	4	3
9	1x26	7x32	cxcr_off	4.05	0	Yes	No	No	No	4	2
10	1x27	7x28	cxcr_off	12.26	0	Yes	No	No	No	6	3
11	1x27	7x31	cxcr_off	10.2	0	Yes	No	No	No	6	4
12	1x27	7x32	cxcr_off	6.99	0	Yes	No	No	No	6	2
13	1x30	1x31	cxcr_off	6.04	0	Yes	No	No	No	4	3
14	1x30	1x34	cxcr_off	4.29	0	Yes	No	No	No	4	5
15	1x30	7x32	cxcr_off	16.13	0	Yes	No	No	No	4	2
16	1x30	7x36	cxcr_off	8.79	0	Yes	No	No	No	4	6
17	1x31	1x35	cxcr_off	9.61	0	No	No	No	No	3	6
18	1x31	7x35	cxcr_off	5.96	0	No	No	No	No	3	5
19	1x34	7x36	cxcr_off	3.77	0	No	No	No	No	5	6
20	1x38	7x40	cxcr_off	7.14	0	No	No	No	No	5	7
21	1x39	2x60	cxcr_off	3.86	0	Yes	Yes	Yes	No	7	7
22	1x42	7x43	cxcr_off	3.77	0	No	No	Yes	No	7	5
23	1x47	2x54	cxcr_off	4.61	0	No	No	Yes	No	5	6
24	1x56	1x60	cxcr_off	4.3	0	No	No	No	No	7	4
25	2x39	3x50	cxcr_off	5.17	0	No	No	Yes	No	7	9
26	2x40	2x43	cxcr_off	4.76	0	No	No	No	No	8	8
27	2x42	3x45	cxcr_off	7.22	0	Yes	Yes	Yes	No	7	5
28	2x42	4x41	cxcr_off	5.34	0	Yes	Yes	No	No	7	3
29	2x43	7x49	cxcr_off	8.44	0	No	No	No	No	8	9
30	2x43	7x53	cxcr_off	17.49	0	No	No	No	Yes	8	9
31	2x45	4x45	cxcr_off	6.92	0	Yes	No	No	No	9	5
32	2x45	4x50	cxcr_off	8.46	0	Yes	No	No	No	9	9
33	2x52	3x31	cxcr_off	8.56	0	No	No	No	No	7	5
34	2x53	2x57	cxcr_off	4.87	0	Yes	No	No	No	7	8
35	2x53	2x60	cxcr_off	6.01	0	Yes	No	Yes	No	7	7
36	2x56	3x28	cxcr_off	4.76	0	No	No	No	No	6	5
37	2x60	7x38	cxcr_off	8.72	0	Yes	No	Yes	No	7	5
38	2x60	7x42	cxcr_off	8.02	0	Yes	No	Yes	Yes	7	7
39	2x60	Lig	cxcr_off	12.53	0	Yes	No	Yes	Yes	7	0
40	2x63	E2	cxcr_off	4.76	0	No	No	Yes	Yes	5	3
41	2x63	Lig	cxcr_off	16.86	0	No	No	Yes	Yes	5	0
42	2x66	E1x51	cxcr_off	4	0	No	No	No	No	5	3
43	E1x49	E1x51	cxcr_off	8.14	0	No	No	No	No	4	3
44	E1x50	E1x52	cxcr_off	17.04	0	Yes	Yes	Yes	Yes	9	7
45	E1x50	Lig	cxcr_off	4.56	0	Yes	Yes	Yes	Yes	9	0
46	3x28	Lig	cxcr_off	4.47	0	No	No	Yes	Yes	5	0
47	3x29	4x61	cxcr_off	6.3	0	Yes	No	No	No	6	4
48	3x29	E2x52	cxcr_off	5.64	0	Yes	No	Yes	No	6	5
49	3x29	Lig	cxcr_off	3.86	0	Yes	No	Yes	Yes	6	0
50	3x32	3x36	cxcr_off	9.38	0	Yes	Yes	No	Yes	6	7
51	3x32	7x42	cxcr_off	6.19	0	Yes	Yes	Yes	Yes	6	7
52	3x35	7x45	cxcr_off	5.1	0	No	No	Yes	No	8	9
53	3x37	5x46	cxcr_off	6.31	0	No	Yes	No	No	7	4
54	3x39	6x44	cxcr_off	3.96	0	No	No	Yes	Yes	9	9
55	3x40	3x41	cxcr_off	3.68	0	No	No	Yes	No	7	5
56	3x41	3x44	cxcr_off	3.89	0	Yes	No	No	No	5	7
57	3x41	4x49	cxcr_off	3.68	0	Yes	No	No	No	5	7
58	3x41	5x50	cxcr_off	16.21	0	Yes	No	No	No	5	9
59	3x43	6x41	cxcr_off	8.56	0	No	No	No	No	8	7
60	3x43	6x44	cxcr_off	8.53	0	No	No	Yes	Yes	8	9
61	3x45	4x40	cxcr_off	6.09	0	Yes	No	No	No	5	4
62	3x45	4x44	cxcr_off	3.93	0	Yes	No	No	No	5	2
63	3x46	6x37	cxcr_off	4.56	0	No	No	No	No	8	7
64	3x48	5x53	cxcr_off	4.47	0	No	No	No	No	6	6
65	3x49	3x50	cxcr_off	8.34	0	No	Yes	Yes	No	8	9
66	3x50	I2x57	cxcr_off	4.26	0	Yes	No	Yes	No	9	6
67	3x50	6x37	cxcr_off	3.88	0	Yes	No	No	No	9	7
68	3x51	3x52	cxcr_off	4.69	0	Yes	Yes	No	No	8	5
69	3x55	3x56	cxcr_off	11.07	0	No	No	No	Yes	7	6
70	I2x53	I2x57	cxcr_off	3.95	0	No	No	Yes	No	5	6
71	4x39	I2x55	cxcr_off	4.86	0	No	No	No	No	4	5
72	4x38	4x42	cxcr_off	13.5	0	No	No	No	Yes	6	7
73	4x39	4x43	cxcr_off	5.64	0	No	No	No	No	4	3
74	4x40	4x44	cxcr_off	4.47	0	No	No	No	No	4	2
75	4x45	4x46	cxcr_off	5.05	0	No	No	No	No	5	7
76	4x46	4x50	cxcr_off	6.75	0	No	No	No	No	7	9
77	4x48	4x52	cxcr_off	4.06	0	No	No	No	No	3	4
78	4x56	5x42	cxcr_off	3.99	0	No	No	No	No	5	3
79	4x57	4x62	cxcr_off	3.89	0	No	No	No	No	6	4
80	4x60	E2x52	cxcr_off	7.21	0	No	No	Yes	No	8	5
81	4x64	5x35	cxcr_off	5.01	0	No	No	No	No	4	5
82	E2	E2x52	cxcr_off	13.38	0	Yes	Yes	Yes	No	3	5
83	5x36	E2	cxcr_off	6.31	0	No	Yes	Yes	Yes	4	3
84	5x39	E2	cxcr_off	10.32	0	No	No	Yes	Yes	5	3
85	5x34	E2	cxcr_off	5.49	0	No	No	Yes	Yes	2	3
86	5x43	6x52	cxcr_off	4.36	0	No	No	No	No	4	8
87	5x45	5x48	cxcr_off	5.83	0	No	No	No	No	4	4
88	5x45	5x49	cxcr_off	4.24	0	No	No	No	No	4	6
89	5x461	5x50	cxcr_off	4.06	0	No	No	No	No	5	9
90	5x58	5x62	cxcr_off	8.46	0	No	Yes	No	No	8	4
91	I3	I3	cxcr_off	4.77	0	Yes	No	Yes	No	4	4
92	6x33	6x36	cxcr_off	3.74	0	No	No	No	No	7	7
93	6x35	6x39	cxcr_off	4.36	0	No	No	No	No	6	5
94	6x43	7x48	cxcr_off	4.73	0	No	No	No	No	6	6
95	6x44	6x45	cxcr_off	6.43	0	Yes	Yes	No	No	9	4
96	6x44	7x45	cxcr_off	7.92	0	Yes	Yes	Yes	No	9	9
97	6x48	6x51	cxcr_off	6.75	0	Yes	Yes	Yes	No	9	7
98	6x48	6x52	cxcr_off	5.79	0	Yes	Yes	No	No	9	8
99	6x51	7x38	cxcr_off	13.47	0	Yes	No	Yes	No	7	5
100	6x58	7x34	cxcr_off	4.2	0	No	Yes	No	No	5	4
101	7x26	E3	cxcr_off	17.82	0	No	No	Yes	Yes	1	3
102	7x31	7x35	cxcr_off	8.37	0	No	No	No	No	4	5
103	7x33	7x37	cxcr_off	9.7	0	No	No	No	No	6	6
104	7x43	7x47	cxcr_off	5.59	0	Yes	No	No	No	5	7
105	7x45	7x46	cxcr_off	7.37	0	Yes	No	No	No	9	9
106	7x49	7x50	cxcr_off	4.89	0	No	No	Yes	No	9	9
107	3x52	I2x57	cxcr_off	3.64	0	No	No	Yes	No	5	6
108	2x49	3x38	cxcr_off	3.42	0	No	No	No	No	8	7
109	4x51	4x52	cxcr_off	3.39	0	No	No	No	No	4	4
110	6x35	6x36	cxcr_off	3.35	0	No	No	No	No	6	7
111	3x52	I2x56	cxcr_off	3.28	0	No	No	No	No	5	4
112	3x44	5x54	cxcr_off	3.25	0	No	No	No	No	7	7
113	3x53	6x32	cxcr_off	3.21	0	No	No	Yes	Yes	8	8
114	1x54	2x47	cxcr_off	3.1	0	No	No	No	No	7	9
115	6x57	7x30	cxcr_off	3.07	0	No	No	No	No	5	5
116	1x45	7x51	cxcr_off	3.04	0	No	No	No	No	5	6
117	2x54	2x57	cxcr_off	2.98	0	Yes	No	No	No	6	8
118	6x34	6x38	cxcr_off	2.98	0	No	No	No	No	5	4
119	5x44	5x48	cxcr_off	2.94	0	No	Yes	No	No	5	4
120	5x48	5x52	cxcr_off	2.94	0	No	No	No	No	4	3
121	3x54	6x32	cxcr_off	2.91	0	No	No	Yes	Yes	8	8
122	2x38	4x38	cxcr_off	2.88	0	No	No	No	No	6	6
123	I2x55	I2x56	cxcr_off	2.88	0	No	No	No	No	5	4
124	3x21	E1x50	cxcr_off	2.81	0	No	No	Yes	Yes	8	9
125	6x47	7x43	cxcr_off	2.79	0	No	No	Yes	No	8	5
126	3x43	6x40	cxcr_off	2.77	0	No	No	No	Yes	8	7
127	6x40	7x48	cxcr_off	2.77	0	No	Yes	No	No	7	6
128	4x38	I2x54	cxcr_off	2.71	0	No	No	No	No	6	5
129	2x45	3x42	cxcr_off	2.65	0	Yes	No	No	No	9	7
130	1x43	2x54	cxcr_off	2.62	0	No	No	Yes	No	6	6
131	5x38	5x39	cxcr_off	2.62	0	No	No	No	No	3	5
132	2x59	3x24	cxcr_off	2.44	0	No	No	No	No	6	5
133	3x51	5x61	cxcr_off	2.42	0	Yes	Yes	No	No	8	8
134	6x53	7x33	cxcr_off	2.35	0	No	No	No	No	6	6
135	3x41	5x49	cxcr_off	2.28	0	Yes	No	No	No	5	6
136	1x51	2x51	cxcr_off	1.71	0	No	No	No	No	3	7
137	6x36	7x52	cxcr_off	1.64	0	No	No	No	No	7	7
138	6x49	6x50	cxcr_off	1.64	0	No	No	No	No	5	9
139	7x23	E3	cxcr_off	1.64	0	No	No	Yes	Yes	5	3
140	3x34	3x38	cxcr_off	1.62	0	No	No	No	No	5	7
141	1x28	1x32	cxcr_off	1.61	0	No	No	No	Yes	1	4
142	6x32	I2x50	cxcr_off	1.61	0	Yes	Yes	No	No	8	8
143	6x55	6x59	cxcr_off	1.55	0	No	No	No	No	5	5
144	1x47	1x48	cxcr_off	1.54	0	No	No	No	No	5	4
145	1x54	2x48	cxcr_off	1.54	0	No	No	No	No	7	5
146	6x38	6x39	cxcr_off	1.54	0	No	No	No	No	4	5
147	1x41	1x45	cxcr_off	1.52	0	No	No	No	No	4	5
148	2x55	2x56	cxcr_off	1.52	0	No	No	No	No	4	6
149	3x45	4x48	cxcr_off	1.51	0	Yes	No	No	No	5	3
150	1x48	1x52	cxcr_off	1.49	0	No	No	No	No	4	5
151	6x38	6x42	cxcr_off	1.49	0	No	No	No	No	4	5
152	5x33	5x36	cxcr_off	1.46	0	No	No	No	Yes	1	4
153	6x30	6x32	cxcr_off	1.44	0	No	No	Yes	Yes	7	8
154	4x51	4x55	cxcr_off	1.43	0	No	No	No	No	4	4
155	5x61	5x65	cxcr_off	1.43	0	No	No	No	No	8	8
156	1x33	1x34	cxcr_off	1.26	0	No	No	No	No	5	5
157	3x23	3x24	cxcr_off	1.22	0	No	No	No	No	1	5
158	6x31	I3	cxcr_off	1.17	0	No	No	Yes	No	5	4
159	Lig	NT	Shared	62.43	59.93	Yes	Yes	Yes	Yes	0	4
160	NT	NT	Shared	10.09	36.11	Yes	Yes	Yes	Yes	4	4
161	7x24	NT	Shared	7.28	7.28	No	No	Yes	Yes	5	4
162	1x35	1x39	Shared	5.86	3.785	No	No	Yes	Yes	6	7
163	1x39	2x61	Shared	4	4	Yes	Yes	No	No	7	7
164	1x39	7x39	Shared	6.67	2.42	Yes	Yes	No	No	7	4
165	1x39	7x42	Shared	5.16	5.515	Yes	Yes	Yes	Yes	7	7
166	1x43	2x58	Shared	7.22	8.665	No	No	No	No	6	9
167	1x45	7x47	Shared	6.76	6.345	No	No	No	No	5	7
168	1x46	2x54	Shared	3.68	2.565	No	No	Yes	No	8	6
169	1x49	7x50	Shared	4.06	1.015	No	No	Yes	No	8	9
170	1x50	2x50	Shared	13.46	10.095	No	No	No	No	9	9
171	1x50	7x50	Shared	11.4	9.775	No	No	Yes	No	9	9
172	1x53	2x47	Shared	6.46	3.39	No	No	No	No	8	9
173	1x54	2x51	Shared	5.71	1.41	No	No	No	No	7	7
174	1x57	2x40	Shared	8.32	2.1	No	No	No	No	6	8
175	1x57	2x44	Shared	4.24	4.28	No	No	No	Yes	6	5
176	2x37	2x40	Shared	10.31	8.835	No	No	No	No	7	8
177	2x38	I2x57	Shared	6.2	9.865	No	No	Yes	No	6	6
178	2x42	3x46	Shared	6.04	6.045	Yes	Yes	No	No	7	8
179	2x42	3x49	Shared	5.75	8.045	Yes	Yes	No	Yes	7	8
180	2x45	4x46	Shared	6.53	7.085	Yes	No	No	No	9	7
181	2x46	3x42	Shared	5.71	4.15	No	Yes	No	No	9	7
182	2x46	7x49	Shared	8.24	11.67	No	Yes	No	No	9	9
183	2x50	7x46	Shared	4.67	7.365	No	No	No	No	9	9
184	2x53	3x32	Shared	5.16	5.58	Yes	No	Yes	Yes	7	6
185	2x53	3x35	Shared	12.08	9.06	Yes	No	No	No	7	8
186	2x53	7x42	Shared	11.79	3.935	Yes	No	Yes	Yes	7	7
187	2x56	3x31	Shared	9.12	4.42	No	No	No	No	6	5
188	2x59	E1x52	Shared	10.72	2.51	No	No	Yes	Yes	6	7
189	2x59	3x28	Shared	3.93	3.075	No	No	No	No	6	5
190	2x60	3x32	Shared	14.47	11.6	Yes	No	Yes	Yes	7	6
191	2x62	E1x52	Shared	6.55	1.385	No	No	Yes	Yes	5	7
192	2x63	E1x50	Shared	4.47	6.795	No	No	Yes	Yes	5	9
193	E1x49	E2	Shared	21.4	3.71	No	No	Yes	Yes	4	3
194	3x25	E1x50	Shared	3.92	6.53	No	No	Yes	Yes	9	9
195	E1x50	E2	Shared	4.9	5.65	Yes	Yes	Yes	Yes	9	3
196	E1x50	E2x50	Shared	14.37	7.835	Yes	Yes	No	No	9	9
197	3x22	3x26	Shared	4.2	6.005	No	No	No	No	3	7
198	3x22	E2	Shared	10	6.33	No	No	Yes	Yes	3	3
199	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
200	3x29	4x65	Shared	8.78	12.52	Yes	No	No	Yes	6	4
201	3x30	4x57	Shared	9.52	3.795	No	No	No	No	5	6
202	3x30	4x62	Shared	9.18	9.55	No	No	No	No	5	4
203	3x33	4x61	Shared	11.56	7.385	No	Yes	No	No	5	4
204	3x37	4x56	Shared	8.21	6.45	No	Yes	No	No	7	5
205	3x37	5x43	Shared	6.53	4.17	No	Yes	No	No	7	4
206	3x38	4x50	Shared	6.18	14.21	No	No	No	No	7	9
207	3x40	5x50	Shared	7.07	3.39	No	No	No	No	7	9
208	3x40	6x44	Shared	3.93	4.395	No	No	Yes	Yes	7	9
209	3x45	4x49	Shared	5.24	3.455	Yes	No	No	No	5	7
210	3x47	5x54	Shared	9.29	3.835	No	No	No	No	9	7
211	3x49	I2x57	Shared	11.91	6.915	No	Yes	Yes	No	8	6
212	3x51	3x55	Shared	6.31	9.465	Yes	Yes	No	No	8	7
213	3x51	3x56	Shared	10.89	6.53	Yes	Yes	No	Yes	8	6
214	3x51	5x60	Shared	6.04	6.705	Yes	Yes	No	No	8	4
215	3x53	I2x57	Shared	6.91	4.015	No	No	Yes	No	8	6
216	3x55	5x64	Shared	6.07	6.35	No	No	No	No	7	4
217	4x42	4x43	Shared	5.4	2.275	No	Yes	No	No	7	3
218	4x60	5x39	Shared	7.22	2.46	No	No	No	No	8	5
219	4x61	E2x52	Shared	13.1	6.61	No	No	Yes	No	4	5
220	4x63	4x64	Shared	11.3	4.875	No	No	No	No	3	4
221	4x64	E2	Shared	14.24	6.02	No	No	Yes	Yes	4	3
222	E2	E2	Shared	43.15	42.4	Yes	Yes	Yes	Yes	3	3
223	E2	Lig	Shared	37.32	42.6	Yes	Yes	Yes	Yes	3	0
224	E2	E2x51	Shared	11.89	4.15	Yes	Yes	No	No	3	3
225	E2x51	Lig	Shared	7.28	16.895	No	No	Yes	Yes	3	0
226	5x35	E2	Shared	24.31	8.45	No	No	Yes	Yes	5	3
227	5x47	6x52	Shared	8.21	12.085	No	No	No	No	8	8
228	6x44	6x48	Shared	8.02	5.015	Yes	Yes	Yes	Yes	9	9
229	6x48	7x41	Shared	6.48	5.63	Yes	Yes	No	No	9	8
230	6x48	7x45	Shared	8.46	10.05	Yes	Yes	Yes	No	9	9
231	6x51	6x55	Shared	6.04	6.45	Yes	No	No	No	7	5
232	6x51	7x37	Shared	6.24	4.37	Yes	No	No	No	7	6
233	6x58	Lig	Shared	17.31	5.63	No	Yes	Yes	Yes	5	0
234	6x60	E3	Shared	13.82	16.2	No	No	Yes	Yes	4	3
235	6x61	7x26	Shared	5.02	2.48	No	Yes	No	No	3	1
236	E3	E3	Shared	4.21	6.325	Yes	Yes	Yes	Yes	3	3
237	7x27	Lig	Shared	21.75	23.555	No	No	Yes	Yes	2	0
238	7x31	Lig	Shared	13.07	2.765	No	No	Yes	Yes	4	0
239	7x38	7x42	Shared	4.66	5.245	Yes	No	Yes	Yes	5	7
240	7x38	Lig	Shared	9.44	9.45	Yes	No	Yes	Yes	5	0
241	Lig	Lig	Shared	437.12	622.265	Yes	Yes	Yes	Yes	0	0
242	1x36	2x65	Shared	3.53	2.375	No	No	No	No	5	4
243	1x53	7x50	Shared	3.53	3.53	No	No	Yes	No	8	9
244	6x54	7x34	Shared	3.53	3.725	No	No	No	No	4	4
245	6x50	7x37	Shared	3.5	4.375	No	No	No	No	9	6
246	6x30	I3	Shared	3.49	4.32	No	No	Yes	No	7	4
247	3x47	5x57	Shared	3.44	5.16	No	No	No	No	9	6
248	1x58	2x44	Shared	3.42	2.77	No	No	No	Yes	2	5
249	3x44	5x53	Shared	3.39	2.505	No	No	No	No	7	6
250	4x59	4x60	Shared	3.39	1.64	No	No	No	No	3	8
251	1x38	7x39	Shared	3.25	2.28	No	No	No	No	5	4
252	3x33	4x57	Shared	3.14	3.665	No	Yes	No	No	5	6
253	6x61	7x30	Shared	3.07	2.19	No	Yes	No	No	3	5
254	6x58	7x30	Shared	2.92	2.8	No	Yes	No	No	5	5
255	7x25	7x29	Shared	2.82	1.23	No	No	No	No	3	2
256	6x40	7x52	Shared	2.77	3.075	No	Yes	No	No	7	7
257	5x41	5x45	Shared	2.49	2.295	No	No	No	No	4	4
258	3x24	E1x52	Shared	2.44	6.09	No	No	Yes	Yes	5	7
259	7x43	7x48	Shared	2.44	3.46	Yes	No	No	No	5	6
260	6x62	Lig	Shared	2.43	7.22	No	Yes	Yes	Yes	3	0
261	2x65	2x66	Shared	1.7	3.695	No	No	No	No	4	5
262	1x35	2x64	Shared	1.58	3.795	No	No	No	No	6	5
263	1x32	2x65	Shared	1.52	3.795	No	Yes	No	No	4	4
264	1x37	1x41	Shared	1.52	2.14	No	No	No	No	4	4
265	3x34	4x54	Shared	1.49	2.25	No	No	No	No	5	3
266	3x54	5x65	Shared	1.43	2.14	No	No	No	No	8	8
267	5x36	5x40	Shared	1.43	3.735	No	Yes	No	Yes	4	5
268	6x63	E3	Shared	1.43	1.585	No	No	Yes	Yes	1	3
269	6x64	E3	Shared	1.35	3.985	No	No	Yes	Yes	2	3
270	1x55	1x59	Shared	1.17	6.45	No	No	No	No	4	5
271	7x28	NT	cxcr_on	0	11.46	No	No	Yes	Yes	3	4
272	1x31	NT	cxcr_on	0	3.635	No	No	Yes	Yes	3	4
273	1x30	1x33	cxcr_on	0	6.63	Yes	No	No	No	4	5
274	1x31	7x32	cxcr_on	0	12.05	No	No	No	No	3	2
275	1x32	1x33	cxcr_on	0	4.775	No	Yes	No	No	4	5
276	1x43	1x47	cxcr_on	0	6.7	No	No	No	No	6	5
277	1x43	2x57	cxcr_on	0	3.655	No	No	No	No	6	8
278	1x46	1x50	cxcr_on	0	5.96	No	No	No	No	8	9
279	1x46	7x46	cxcr_on	0	4.075	No	No	No	No	8	9
280	1x52	7x55	cxcr_on	0	6.09	No	No	No	No	5	0
281	1x52	8x54	cxcr_on	0	5.815	No	No	No	No	5	0
282	1x53	7x54	cxcr_on	0	4.24	No	No	No	No	8	7
283	1x56	8x50	cxcr_on	0	7.865	No	No	No	Yes	7	0
284	1x57	8x50	cxcr_on	0	4.395	No	No	No	Yes	6	0
285	1x59	8x57	cxcr_on	0	10.275	No	No	No	No	5	0
286	2x38	3x49	cxcr_on	0	6.57	No	No	No	Yes	6	8
287	2x38	4x42	cxcr_on	0	5.615	No	No	No	Yes	6	7
288	2x41	4x42	cxcr_on	0	4.01	No	No	No	Yes	6	7
289	2x42	4x42	cxcr_on	0	6.31	Yes	Yes	No	Yes	7	7
290	2x46	3x43	cxcr_on	0	4.15	No	Yes	No	No	9	8
291	2x48	2x52	cxcr_on	0	4.15	No	No	No	No	5	7
292	2x50	7x49	cxcr_on	0	9.425	No	No	No	No	9	9
293	2x52	3x35	cxcr_on	0	4.805	No	No	No	No	7	8
294	2x56	3x32	cxcr_on	0	3.755	No	No	Yes	Yes	6	6
295	2x57	7x42	cxcr_on	0	5.395	No	No	Yes	Yes	8	7
296	2x64	7x35	cxcr_on	0	4.15	No	No	No	No	5	5
297	E1x51	E1x52	cxcr_on	0	5.655	No	No	Yes	Yes	3	7
298	3x32	3x33	cxcr_on	0	5.4	Yes	Yes	No	Yes	6	5
299	3x33	3x36	cxcr_on	0	6.41	No	Yes	No	Yes	5	7
300	3x36	3x37	cxcr_on	0	6.705	No	Yes	No	Yes	7	7
301	3x36	6x48	cxcr_on	0	10.025	No	Yes	Yes	Yes	7	9
302	3x38	4x53	cxcr_on	0	6.52	No	No	No	No	7	7
303	3x40	6x48	cxcr_on	0	9.395	No	No	Yes	Yes	7	9
304	3x42	4x49	cxcr_on	0	3.805	No	No	No	No	7	7
305	3x43	7x53	cxcr_on	0	9.965	No	No	No	Yes	8	9
306	3x46	3x50	cxcr_on	0	5.01	No	No	Yes	No	8	9
307	3x46	7x53	cxcr_on	0	3.625	No	No	No	Yes	8	9
308	3x47	5x58	cxcr_on	0	14.625	No	No	No	Yes	9	8
309	3x50	5x58	cxcr_on	0	9.26	Yes	No	No	Yes	9	8
310	3x50	7x53	cxcr_on	0	4.63	Yes	No	No	Yes	9	9
311	3x51	5x57	cxcr_on	0	5.38	Yes	Yes	No	No	8	6
312	3x54	5x61	cxcr_on	0	4.56	No	No	No	No	8	8
313	3x56	I2x54	cxcr_on	0	4.5	No	Yes	No	No	6	5
314	I2x52	I2x55	cxcr_on	0	5.82	No	Yes	No	No	5	5
315	4x52	5x46	cxcr_on	0	4.26	No	No	No	No	4	4
316	4x56	5x46	cxcr_on	0	4.26	No	No	No	No	5	4
317	4x61	4x65	cxcr_on	0	4.515	No	No	No	Yes	4	4
318	4x65	E2x50	cxcr_on	0	7.66	No	Yes	No	No	4	9
319	4x65	E2x52	cxcr_on	0	12.21	No	Yes	Yes	No	4	5
320	5x36	E2x51	cxcr_on	0	13.89	No	Yes	No	No	4	3
321	5x39	E2x52	cxcr_on	0	4.64	No	No	Yes	No	5	5
322	5x32	E2	cxcr_on	0	6.565	No	No	Yes	Yes	0	3
323	5x31	5x34	cxcr_on	0	8.245	No	No	No	No	0	2
324	5x36	Lig	cxcr_on	0	4.07	No	Yes	Yes	Yes	4	0
325	5x37	6x59	cxcr_on	0	5.27	No	No	No	No	3	5
326	5x37	6x62	cxcr_on	0	8.685	No	No	No	Yes	3	3
327	5x40	6x55	cxcr_on	0	12.755	No	Yes	No	No	5	5
328	5x40	6x58	cxcr_on	0	7.74	No	Yes	No	Yes	5	5
329	5x40	6x59	cxcr_on	0	4.53	No	Yes	No	No	5	5
330	5x44	6x52	cxcr_on	0	5.74	No	Yes	No	No	5	8
331	5x44	6x55	cxcr_on	0	3.88	No	Yes	No	No	5	5
332	5x47	6x49	cxcr_on	0	5.48	No	No	No	No	8	5
333	5x51	6x44	cxcr_on	0	3.655	No	No	Yes	Yes	6	9
334	5x51	6x45	cxcr_on	0	4.845	No	No	No	No	6	4
335	5x54	6x44	cxcr_on	0	6.22	No	No	Yes	Yes	7	9
336	5x55	6x41	cxcr_on	0	4.47	No	No	No	No	4	7
337	5x58	6x37	cxcr_on	0	9.67	No	Yes	No	No	8	7
338	5x58	6x40	cxcr_on	0	3.785	No	Yes	No	Yes	8	7
339	5x62	6x34	cxcr_on	0	4.24	No	No	No	No	4	5
340	5x62	6x37	cxcr_on	0	5.71	No	No	No	No	4	7
341	5x62	6x38	cxcr_on	0	4.875	No	No	No	No	4	4
342	5x66	6x34	cxcr_on	0	3.735	No	No	No	No	4	5
343	6x30	6x31	cxcr_on	0	3.93	No	No	No	No	7	5
344	6x36	7x56	cxcr_on	0	5.375	No	No	No	No	7	0
345	6x40	7x53	cxcr_on	0	5.68	No	Yes	No	Yes	7	9
346	6x47	7x45	cxcr_on	0	8.85	No	No	Yes	No	8	9
347	6x51	6x52	cxcr_on	0	4.07	Yes	No	No	No	7	8
348	6x58	6x62	cxcr_on	0	6.55	No	Yes	No	Yes	5	3
349	6x61	E3	cxcr_on	0	8.535	No	Yes	Yes	Yes	3	3
350	7x23	7x25	cxcr_on	0	4.31	No	No	No	No	5	3
351	7x34	Lig	cxcr_on	0	6.8	No	No	Yes	Yes	4	0
352	7x49	7x53	cxcr_on	0	4.65	No	No	No	Yes	9	9
353	7x54	8x50	cxcr_on	0	5.545	No	No	No	Yes	7	0
354	7x55	8x50	cxcr_on	0	4.825	No	No	No	Yes	0	0
355	E2	NT	cxcr_on	0	5.915	Yes	Yes	Yes	Yes	3	4
356	1x32	NT	cxcr_on	0	4.725	No	Yes	Yes	Yes	4	4
357	7x32	NT	cxcr_on	0	5.27	No	No	Yes	Yes	2	4
358	1x29	1x34	cxcr_on	0	4.665	No	No	No	No	3	5
359	1x30	1x32	cxcr_on	0	3.635	Yes	No	No	Yes	4	4
360	1x59	8x61	cxcr_on	0	3.81	No	No	No	No	5	0
361	3x24	E1x50	cxcr_on	0	3.985	No	No	Yes	Yes	5	9
362	3x33	3x37	cxcr_on	0	6.175	No	Yes	No	Yes	5	7
363	3x34	3x35	cxcr_on	0	3.695	No	No	No	No	5	8
364	3x36	5x44	cxcr_on	0	5.27	No	Yes	No	Yes	7	5
365	3x37	5x44	cxcr_on	0	3.945	No	Yes	No	Yes	7	5
366	3x56	I2x52	cxcr_on	0	3.95	No	Yes	No	Yes	6	5
367	3x56	I2x53	cxcr_on	0	6.16	No	Yes	No	No	6	5
368	I2x51	I2x52	cxcr_on	0	5.82	No	No	No	Yes	5	5
369	4x41	4x44	cxcr_on	0	4.87	No	No	No	No	3	2
370	5x36	6x62	cxcr_on	0	3.73	No	Yes	No	Yes	4	3
371	6x31	6x35	cxcr_on	0	4.515	No	No	No	No	5	6
372	6x62	7x27	cxcr_on	0	5.865	No	Yes	No	No	3	2
373	8x48	8x52	cxcr_on	0	5.565	No	No	No	No	0	0
374	5x49	5x50	cxcr_on	0	3.53	No	No	No	No	6	9
375	3x41	4x52	cxcr_on	0	3.46	Yes	No	No	No	5	4
376	7x40	7x43	cxcr_on	0	3.46	No	No	Yes	No	7	5
377	2x44	2x45	cxcr_on	0	3.435	No	Yes	Yes	No	5	9
378	6x43	7x45	cxcr_on	0	3.315	No	No	Yes	No	6	9
379	5x45	5x46	cxcr_on	0	3.245	No	No	No	No	4	4
380	3x34	4x53	cxcr_on	0	3.235	No	No	No	No	5	7
381	3x52	3x56	cxcr_on	0	3.215	No	No	No	Yes	5	6
382	5x56	5x60	cxcr_on	0	3.215	No	No	No	No	3	4
383	6x32	8x51	cxcr_on	0	3.2	Yes	Yes	No	No	8	0
384	1x29	1x33	cxcr_on	0	3.12	No	No	No	No	3	5
385	3x54	5x64	cxcr_on	0	3.04	No	No	No	No	8	4
386	7x37	7x40	cxcr_on	0	2.95	No	No	No	No	6	7
387	6x32	8x48	cxcr_on	0	2.92	Yes	Yes	No	No	8	0
388	3x37	5x461	cxcr_on	0	2.9	No	Yes	No	No	7	5
389	1x54	2x44	cxcr_on	0	2.83	No	No	No	Yes	7	5
390	3x44	5x50	cxcr_on	0	2.805	No	No	No	No	7	9
391	5x31	E2	cxcr_on	0	2.725	No	No	Yes	Yes	0	3
392	I2x52	I2x58	cxcr_on	0	2.665	No	Yes	No	No	5	0
393	8x60	8x61	cxcr_on	0	2.65	No	No	No	No	0	0
394	2x49	4x50	cxcr_on	0	2.59	No	No	No	No	8	9
395	6x54	7x33	cxcr_on	0	2.545	No	No	No	No	4	6
396	5x58	6x41	cxcr_on	0	2.525	No	Yes	No	No	8	7
397	5x47	5x48	cxcr_on	0	2.515	No	No	No	No	8	4
398	2x42	4x45	cxcr_on	0	2.47	Yes	Yes	No	No	7	5
399	5x42	5x43	cxcr_on	0	2.46	No	No	No	No	3	4
400	6x39	7x52	cxcr_on	0	2.435	No	No	No	No	5	7
401	5x52	5x56	cxcr_on	0	2.435	No	No	No	No	3	3
402	5x68	I3	cxcr_on	0	2.415	No	No	Yes	No	0	4
403	2x43	7x54	cxcr_on	0	2.365	No	No	No	No	8	7
404	6x29	6x32	cxcr_on	0	2.34	No	No	Yes	Yes	0	8
405	1x42	2x57	cxcr_on	0	2.235	No	No	No	No	7	8
406	2x39	3x49	cxcr_on	0	2.17	No	No	No	Yes	7	8
407	6x49	6x53	cxcr_on	0	2.075	No	No	No	No	5	6
408	I2x54	I2x56	cxcr_on	0	1.995	No	No	No	No	5	4
409	7x23	7x26	cxcr_on	0	1.955	No	No	No	No	5	1
410	7x56	8x47	cxcr_on	0	1.76	No	No	No	No	0	0
411	1x42	7x47	cxcr_on	0	1.71	No	No	No	No	7	7
412	1x48	1x49	cxcr_on	0	1.71	No	No	No	No	4	8
413	2x46	3x39	cxcr_on	0	1.71	No	Yes	No	No	9	9
414	3x48	5x57	cxcr_on	0	1.71	No	No	No	No	6	6
415	2x40	I1x50	cxcr_on	0	1.675	No	No	No	No	8	0
416	5x60	5x63	cxcr_on	0	1.605	No	No	No	No	4	4
417	5x65	6x33	cxcr_on	0	1.58	No	No	No	No	8	7
418	1x56	8x57	cxcr_on	0	1.535	No	No	No	No	7	0
419	3x21	E1x52	cxcr_on	0	1.51	No	No	Yes	Yes	8	7
420	1x36	1x37	cxcr_on	0	1.505	No	No	No	No	5	4
421	3x24	3x27	cxcr_on	0	1.49	No	No	No	No	5	4
422	6x41	6x42	cxcr_on	0	1.49	No	No	No	No	7	5
423	4x50	4x51	cxcr_on	0	1.41	No	No	No	No	9	4
424	5x33	6x62	cxcr_on	0	1.385	No	No	No	Yes	1	3
425	6x56	6x60	cxcr_on	0	1.385	No	No	No	No	5	4
426	4x55	4x56	cxcr_on	0	1.385	No	No	No	No	4	5
427	7x48	7x51	cxcr_on	0	1.385	No	No	No	No	6	6
428	8x54	8x58	cxcr_on	0	1.385	No	No	No	No	0	0
429	2x41	I1x51	cxcr_on	0	1.31	No	No	No	No	6	0
430	3x23	3x27	cxcr_on	0	1.31	No	No	No	No	1	4
431	6x32	7x56	cxcr_on	0	1.255	Yes	Yes	No	No	8	0
432	8x49	8x50	cxcr_on	0	1.24	No	No	No	Yes	0	0
433	1x56	8x53	cxcr_on	0	0.92	No	No	No	No	7	0
434	I1x49	I1x50	cxcr_on	0	0.92	No	No	No	No	0	0
435	6x29	I3	cxcr_on	0	0.82	No	No	Yes	No	0	4
436	1x60	I1x49	cxcr_on	0	0.81	No	No	No	No	4	0
437	6x57	6x61	cxcr_on	0	0.805	No	No	No	Yes	5	3
438	6x36	6x40	cxcr_on	0	0.8	No	No	No	Yes	7	7
439	6x46	6x47	cxcr_on	0	0.795	No	No	No	No	5	8
440	1x51	1x54	cxcr_on	0	0.765	No	No	No	No	3	7
441	1x60	8x56	cxcr_on	0	0.765	No	No	No	No	4	0
442	4x41	4x45	cxcr_on	0	0.745	No	No	No	No	3	5
443	5x38	5x41	cxcr_on	0	0.715	No	No	No	No	3	4
444	1x47	2x55	cxcr_on	0	0.69	No	No	No	No	5	4
445	1x44	1x47	cxcr_on	0	0.69	No	No	No	No	5	5
446	2x52	2x55	cxcr_on	0	0.69	No	No	No	No	7	4
447	4x41	I2x59	cxcr_on	0	0.585	No	No	No	No	3	0

Orange: nodes, hubs and links specific of cxcr_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cxcr_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	cxcr_off Avg Int. Strength	cxcr_on Avg Int. Strength	cxcr_off Num Of Links	cxcr_on Num Of Links	ConSurf
1	1x24	cxcr_off	11	0	4	0	5
2	1x26	cxcr_off	7.515	0	4	0	4
3	1x27	cxcr_off	8.3475	0	4	0	6
4	1x30	cxcr_off	8.8125	5.1325	4	2	4
5	2x45	cxcr_off	6.14	5.26	4	2	9
6	2x53	cxcr_off	7.982	6.19167	5	3	7
7	2x54	cxcr_off	3.4725	2.565	4	1	6
8	2x60	cxcr_off	8.935	11.6	6	1	7
9	3x29	cxcr_off	6.145	12.52	4	1	6
10	3x41	cxcr_off	5.948	3.46	5	1	5
11	3x45	cxcr_off	4.798	3.455	5	1	5
12	3x50	cxcr_off	5.4125	6.3	4	3	9
13	I2x57	cxcr_off	6.145	6.93167	6	3	6
14	E2x52	cxcr_off	9.8325	7.82	4	3	5
15	I3	cxcr_off	3.55	2.51833	4	3	4
16	6x51	cxcr_off	8.125	4.96333	4	3	7
17	7x38	cxcr_off	9.0725	7.3475	4	2	5
18	7x43	cxcr_off	3.6475	3.46	4	2	5
19	7x45	cxcr_off	7.2125	7.405	4	3	9
20	7x50	cxcr_off	5.97	4.77333	4	3	9
21	NT	Shared	18.1617	18.9372	6	9	4
22	1x39	Shared	5.11	3.93	5	4	7
23	2x42	Shared	6.0875	5.7175	4	4	7
24	E1x50	Shared	7.43857	6.159	7	5	9
25	E1x52	Shared	9.1875	3.43	4	5	7
26	3x32	Shared	8.8	6.58375	4	4	6
27	3x51	Shared	6.07	7.02	5	4	8
28	E2	Shared	17.9014	14.7429	14	12	3
29	6x32	Shared	2.2925	2.42875	4	4	8
30	6x44	Shared	6.465	4.82125	6	4	9
31	6x48	Shared	7.1	8.023	5	5	9
32	E3	Shared	6.35429	7.15917	7	6	3
33	7x42	Shared	7.164	5.0225	5	4	7
34	Lig	Shared	69.0794	118.62	16	12	0
35	1x32	cxcr_on	1.565	4.2325	2	4	4
36	2x44	cxcr_on	3.83	3.32875	2	4	5
37	2x46	cxcr_on	6.975	5.42	2	4	9
38	3x33	cxcr_on	7.35	5.807	2	5	5
39	3x36	cxcr_on	9.38	7.1025	1	4	7
40	3x37	cxcr_on	7.01667	5.0575	3	6	7
41	3x49	cxcr_on	8.66667	5.925	3	4	8
42	3x56	cxcr_on	10.98	4.871	2	5	6
43	I2x52	cxcr_on	0	4.56375	0	4	5
44	4x42	cxcr_on	9.45	4.5525	2	4	7
45	4x65	cxcr_on	8.78	9.22625	1	4	4
46	5x36	cxcr_on	3.06667	6.35625	3	4	4
47	5x40	cxcr_on	1.43	7.19	1	4	5
48	5x44	cxcr_on	2.94	4.70875	1	4	5
49	5x58	cxcr_on	8.46	7.973	1	5	8
50	6x40	cxcr_on	2.77	3.335	3	4	7
51	6x58	cxcr_on	8.14333	5.68	3	4	5
52	6x61	cxcr_on	4.045	3.5025	2	4	3
53	6x62	cxcr_on	2.43	5.5725	1	6	3
54	7x53	cxcr_on	17.49	5.71	1	5	9
55	8x50	cxcr_on	0	4.774	0	5	0

Orange: nodes, hubs and links specific of cxcr_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cxcr_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	cxcr_off Recurrence	cxcr_on Recurrence	cxcr_off Hub1?	cxcr_on Hub1?	cxcr_off Hub2?	cxcr_on Hub2?	ConSurf1	ConSurf2
1	1x27	7x31	cxcr_off	13.5392	0	Yes	No	No	No	6	4
2	7x31	Lig	cxcr_off	22.7106	1.4412	No	No	Yes	Yes	4	0
3	1x30	1x31	cxcr_off	17.8787	0	Yes	No	No	No	4	3
4	1x30	1x34	cxcr_off	11.4292	0	Yes	No	No	No	4	5
5	1x35	1x39	cxcr_off	23.3999	2.71364	No	No	Yes	Yes	6	7
6	1x39	2x60	cxcr_off	22.6403	0	Yes	Yes	Yes	No	7	7
7	2x60	Lig	cxcr_off	29.0477	0	Yes	No	Yes	Yes	7	0
8	1x39	7x39	cxcr_off	11.387	1.81355	Yes	Yes	No	No	7	4
9	7x38	7x42	cxcr_off	10.4515	7.28636	Yes	No	Yes	Yes	5	7
10	7x38	Lig	cxcr_off	80.806	6.89794	Yes	No	Yes	Yes	5	0
11	7x43	7x48	cxcr_off	15.5226	3.72623	Yes	No	No	No	5	6
12	6x40	7x48	cxcr_off	19.2643	0	No	Yes	No	No	7	6
13	3x43	6x40	cxcr_off	35.3988	0	No	No	No	Yes	8	7
14	3x43	6x44	cxcr_off	38.7537	0	No	No	Yes	Yes	8	9
15	6x48	6x51	cxcr_off	98.9309	0	Yes	Yes	Yes	No	9	7
16	6x51	7x38	cxcr_off	100	0	Yes	No	Yes	No	7	5
17	2x54	2x57	cxcr_off	12.3505	0	Yes	No	No	No	6	8
18	2x53	2x57	cxcr_off	14.0596	0	Yes	No	No	No	7	8
19	2x53	2x60	cxcr_off	34.6533	0	Yes	No	Yes	No	7	7
20	2x50	7x46	cxcr_off	59.5372	4.39057	No	No	No	No	9	9
21	7x45	7x46	cxcr_off	61.4643	0	Yes	No	No	No	9	9
22	3x35	7x45	cxcr_off	47.7282	0	No	No	Yes	No	8	9
23	6x48	7x45	cxcr_off	21.8526	4.10126	Yes	Yes	Yes	No	9	9
24	1x53	2x47	cxcr_off	11.4573	1.53228	No	No	No	No	8	9
25	2x40	2x43	cxcr_off	11.4573	0	No	No	No	No	8	8
26	2x43	7x49	cxcr_off	15.8109	0	No	No	No	No	8	9
27	7x49	7x50	cxcr_off	39.4922	0	No	No	Yes	No	9	9
28	3x49	I2x57	cxcr_off	46.624	1.73855	No	Yes	Yes	No	8	6
29	2x42	3x49	cxcr_off	51.7724	4.33967	Yes	Yes	No	Yes	7	8
30	2x42	3x45	cxcr_off	58.1376	0	Yes	Yes	Yes	No	7	5
31	3x45	4x49	cxcr_off	68.5329	2.94133	Yes	No	No	No	5	7
32	3x41	4x49	cxcr_off	69.9606	0	Yes	No	No	No	5	7
33	3x40	3x41	cxcr_off	86.4819	0	No	No	Yes	No	7	5
34	3x40	6x44	cxcr_off	90.8145	2.36807	No	No	Yes	Yes	7	9
35	2x45	3x42	cxcr_off	18.1671	0	Yes	No	No	No	9	7
36	2x46	3x42	cxcr_off	20.3756	8.81329	No	Yes	No	No	9	7
37	2x46	7x49	cxcr_off	22.57	7.71497	No	Yes	No	No	9	9
38	2x45	4x50	cxcr_off	11.4221	0	Yes	No	No	No	9	9
39	3x28	Lig	cxcr_off	14.0385	0	No	No	Yes	Yes	5	0
40	E1x50	Lig	cxcr_off	12.8851	0	Yes	Yes	Yes	Yes	9	0
41	E1x49	E1x51	cxcr_off	11.1338	0	No	No	No	No	4	3
42	E1x49	E2	cxcr_off	12.8499	2.53951	No	No	Yes	Yes	4	3
43	3x29	Lig	cxcr_off	16.6549	0	Yes	No	Yes	Yes	6	0
44	6x48	6x52	cxcr_off	12.4701	0	Yes	Yes	No	No	9	8
45	3x41	3x44	cxcr_off	11.7246	0	Yes	No	No	No	5	7
46	3x51	3x52	cxcr_off	13.5321	0	Yes	Yes	No	No	8	5
47	3x52	I2x57	cxcr_off	20.8538	0	No	No	Yes	No	5	6
48	3x53	I2x57	cxcr_off	15.3678	0.884007	No	No	Yes	No	8	6
49	3x41	5x49	cxcr_off	11.7246	0	Yes	No	No	No	5	6
50	3x53	6x32	cxcr_off	13.4829	0	No	No	Yes	Yes	8	8
51	6x36	7x52	cxcr_off	13.6306	0	No	No	No	No	7	7
52	6x40	7x52	cxcr_off	15.5226	1.77605	No	Yes	No	No	7	7
53	6x61	7x26	cxcr_off	11.2182	3.57621	No	Yes	No	No	3	1
54	6x61	7x30	cxcr_off	13.0398	9.633	No	Yes	No	No	3	5
55	1x31	1x35	cxcr_off	16.2681	0	No	No	No	No	3	6
56	1x39	7x42	cxcr_off	18.8282	6.26038	Yes	Yes	Yes	Yes	7	7
57	6x44	7x45	cxcr_off	38.7115	0	Yes	Yes	Yes	No	9	9
58	6x44	6x48	Shared	76.6493	96.981	Yes	Yes	Yes	Yes	9	9
59	1x50	7x50	Shared	55.6407	49.1106	No	No	Yes	No	9	9
60	1x50	2x50	Shared	57.596	53.0485	No	No	No	No	9	9
61	2x53	3x35	Shared	47.679	11.2751	Yes	No	No	No	7	8
62	1x53	7x50	Shared	13.708	45.0201	No	No	Yes	No	8	9
63	E2	Lig	Shared	38.0926	16.9542	Yes	Yes	Yes	Yes	3	0
64	6x58	Lig	Shared	21.8244	22.577	No	Yes	Yes	Yes	5	0
65	6x58	7x30	Shared	16.6409	10.4768	No	Yes	No	No	5	5
66	2x53	7x42	Shared	11.6331	13.7075	Yes	No	Yes	Yes	7	7
67	1x32	NT	cxcr_on	0	14.6504	No	Yes	Yes	Yes	4	4
68	Lig	NT	cxcr_on	5.34534	20.2598	Yes	Yes	Yes	Yes	0	4
69	2x50	7x49	cxcr_on	0	58.5775	No	No	No	No	9	9
70	7x49	7x53	cxcr_on	0	66.2684	No	No	No	Yes	9	9
71	3x50	7x53	cxcr_on	0	35.6764	Yes	No	No	Yes	9	9
72	3x50	5x58	cxcr_on	0	46.7452	Yes	No	No	Yes	9	8
73	3x47	5x58	cxcr_on	0	95.0362	No	No	No	Yes	9	8
74	3x47	5x54	cxcr_on	3.95977	98.974	No	No	No	No	9	7
75	5x54	6x44	cxcr_on	0	99.0571	No	No	Yes	Yes	7	9
76	3x36	6x48	cxcr_on	0	100	No	Yes	Yes	Yes	7	9
77	3x36	5x44	cxcr_on	0	61.4091	No	Yes	No	Yes	7	5
78	5x44	6x55	cxcr_on	0	59.7884	No	Yes	No	No	5	5
79	5x40	6x55	cxcr_on	0	59.6223	No	Yes	No	No	5	5
80	5x36	5x40	cxcr_on	1.88493	29.2687	No	Yes	No	Yes	4	5
81	5x36	Lig	cxcr_on	0	19.7884	No	Yes	Yes	Yes	4	0
82	6x40	7x53	cxcr_on	0	38.5186	No	Yes	No	Yes	7	9
83	5x58	6x40	cxcr_on	0	46.0461	No	Yes	No	Yes	8	7
84	5x40	6x58	cxcr_on	0	29.5044	No	Yes	No	Yes	5	5
85	7x54	8x50	cxcr_on	0	39.491	No	No	No	Yes	7	0
86	1x53	7x54	cxcr_on	0	42.2663	No	No	No	No	8	7
87	1x56	8x50	cxcr_on	0	10.5572	No	No	No	Yes	7	0
88	1x57	8x50	cxcr_on	0	20.9965	No	No	No	Yes	6	0
89	1x57	2x44	cxcr_on	4.6209	10.6268	No	No	No	Yes	6	5
90	2x42	3x46	cxcr_on	3.69954	12.7752	Yes	Yes	No	No	7	8
91	3x46	3x50	cxcr_on	0	10.584	No	No	Yes	No	8	9
92	2x53	3x32	cxcr_on	1.82163	20.7045	Yes	No	Yes	Yes	7	6
93	E1x50	E2	cxcr_on	1.8357	11.4332	Yes	Yes	Yes	Yes	9	3
94	E1x50	E2x50	cxcr_on	1.899	13.6619	Yes	Yes	No	No	9	9
95	4x65	E2x50	cxcr_on	0	14.7361	No	Yes	No	No	4	9
96	3x32	3x33	cxcr_on	0	22.7511	Yes	Yes	No	Yes	6	5
97	3x33	4x61	cxcr_on	7.72964	18.9392	No	Yes	No	No	5	4
98	4x61	4x65	cxcr_on	0	15.2022	No	No	No	Yes	4	4
99	3x47	5x57	cxcr_on	1.9834	21.46	No	No	No	No	9	6
100	3x51	5x57	cxcr_on	0	19.6116	Yes	Yes	No	No	8	6
101	5x44	6x52	cxcr_on	0	10.8626	No	Yes	No	No	5	8
102	6x36	7x56	cxcr_on	0	10.3134	No	No	No	No	7	0
103	6x36	6x40	cxcr_on	0	11.1439	No	No	No	Yes	7	7
104	6x51	7x37	cxcr_on	9.27697	11.1197	Yes	No	No	No	7	6
105	3x33	3x36	cxcr_on	0	37.3239	No	Yes	No	Yes	5	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
Lig	NT	Shared	62.43	59.93	1	1	0	1
NT	NT	Shared	10.09	36.11	1	1	1	1
1x24	NT	cxcr_off	9.75	0	1	0	1	1
7x24	NT	Shared	7.28	7.28	0	0	2	1
1x25	NT	cxcr_off	9.33	0	0	0	2	1
1x24	7x27	cxcr_off	9.3	0	1	0	1	1
1x24	7x28	cxcr_off	7.23	0	1	0	1	2
1x24	Lig	cxcr_off	17.72	0	1	0	1	0
1x27	7x28	cxcr_off	12.26	0	1	0	2	2
1x27	7x31	cxcr_off	10.2	0	1	0	2	1
1x27	7x32	cxcr_off	6.99	0	1	0	2	2
1x31	7x35	cxcr_off	5.96	0	0	1	2	2
1x39	2x60	cxcr_off	3.86	0	1	0	2	1
1x39	7x42	Shared	5.16	5.515	1	0	2	2
2x53	2x60	cxcr_off	6.01	0	1	0	2	1
2x53	3x32	Shared	5.16	5.58	1	0	2	2
2x53	7x42	Shared	11.79	3.935	1	0	2	2
2x56	3x28	cxcr_off	4.76	0	0	0	2	1
2x59	E1x52	Shared	10.72	2.51	1	0	2	2
2x59	3x28	Shared	3.93	3.075	1	0	2	1
2x60	3x32	Shared	14.47	11.6	1	0	1	2
2x60	7x38	cxcr_off	8.72	0	1	0	1	1
2x60	7x42	cxcr_off	8.02	0	1	0	1	2
2x60	Lig	cxcr_off	12.53	0	1	0	1	0
2x63	E1x50	Shared	4.47	6.795	1	0	1	1
2x63	E2	cxcr_off	4.76	0	1	0	1	1
2x63	Lig	cxcr_off	16.86	0	1	0	1	0
E1x49	E2	Shared	21.4	3.71	1	0	2	1
E1x50	E1x52	cxcr_off	17.04	0	1	1	1	2
3x25	E1x50	Shared	3.92	6.53	1	1	2	1
E1x50	E2	Shared	4.9	5.65	1	1	1	1
E1x50	E2x50	Shared	14.37	7.835	1	1	1	2
E1x50	Lig	cxcr_off	4.56	0	1	1	1	0
3x22	E2	Shared	10	6.33	1	1	2	1
3x25	E2x50	Shared	7.28	7.28	1	1	2	2
3x28	Lig	cxcr_off	4.47	0	1	0	1	0
3x29	4x61	cxcr_off	6.3	0	1	0	1	2
3x29	4x65	Shared	8.78	12.52	1	0	1	2
3x29	E2x52	cxcr_off	5.64	0	1	0	1	2
3x29	Lig	cxcr_off	3.86	0	1	0	1	0
3x32	7x42	cxcr_off	6.19	0	1	0	2	2
4x61	E2x52	Shared	13.1	6.61	1	1	2	2
4x64	E2	Shared	14.24	6.02	1	1	2	1
4x64	5x35	cxcr_off	5.01	0	1	1	2	2
E2	E2	Shared	43.15	42.4	1	1	1	1
E2	Lig	Shared	37.32	42.6	1	1	1	0
E2	E2x51	Shared	11.89	4.15	1	1	1	1
E2x51	Lig	Shared	7.28	16.895	1	1	1	0
E2	E2x52	cxcr_off	13.38	0	1	1	1	2
5x35	E2	Shared	24.31	8.45	1	0	2	1
5x36	E2	cxcr_off	6.31	0	1	1	1	1
5x39	E2	cxcr_off	10.32	0	1	0	2	1
5x34	E2	cxcr_off	5.49	0	0	0	2	1
6x51	7x38	cxcr_off	13.47	0	0	0	2	1
6x58	7x34	cxcr_off	4.2	0	1	1	1	1
6x58	Lig	Shared	17.31	5.63	1	1	1	0
7x27	Lig	Shared	21.75	23.555	1	1	1	0
7x31	7x35	cxcr_off	8.37	0	1	0	1	2
7x31	Lig	Shared	13.07	2.765	1	0	1	0
7x38	7x42	Shared	4.66	5.245	1	1	1	2
7x38	Lig	Shared	9.44	9.45	1	1	1	0
6x54	7x34	Shared	3.53	3.725	0	0	2	1
6x58	7x30	Shared	2.92	2.8	1	1	1	2
3x21	E1x50	cxcr_off	2.81	0	0	0	2	1
2x59	3x24	cxcr_off	2.44	0	1	0	2	2
3x24	E1x52	Shared	2.44	6.09	1	0	2	2
6x62	Lig	Shared	2.43	7.22	0	1	1	0
5x33	5x36	cxcr_off	1.46	0	0	0	2	1
5x36	5x40	Shared	1.43	3.735	1	1	1	2
7x28	NT	cxcr_on	0	11.46	1	0	2	1
1x31	NT	cxcr_on	0	3.635	0	1	2	1
1x31	7x32	cxcr_on	0	12.05	0	1	2	2
2x56	3x32	cxcr_on	0	3.755	0	0	2	2
4x61	4x65	cxcr_on	0	4.515	1	1	2	2
4x65	E2x50	cxcr_on	0	7.66	0	1	2	2
4x65	E2x52	cxcr_on	0	12.21	0	1	2	2
5x36	E2x51	cxcr_on	0	13.89	1	1	1	1
5x39	E2x52	cxcr_on	0	4.64	1	0	2	2
5x32	E2	cxcr_on	0	6.565	0	0	2	1
5x31	5x34	cxcr_on	0	8.245	0	1	2	2
5x36	Lig	cxcr_on	0	4.07	1	1	1	0
5x37	6x62	cxcr_on	0	8.685	0	0	2	1
5x40	6x58	cxcr_on	0	7.74	0	0	2	1
6x58	6x62	cxcr_on	0	6.55	1	1	1	1
7x34	Lig	cxcr_on	0	6.8	0	1	1	0
E2	NT	cxcr_on	0	5.915	1	1	1	1
1x32	NT	cxcr_on	0	4.725	0	1	2	1
7x32	NT	cxcr_on	0	5.27	1	1	2	1
3x24	E1x50	cxcr_on	0	3.985	1	0	2	1
5x36	6x62	cxcr_on	0	3.73	1	1	1	1
6x62	7x27	cxcr_on	0	5.865	0	1	1	1
5x31	E2	cxcr_on	0	2.725	0	1	2	1
3x21	E1x52	cxcr_on	0	1.51	0	0	2	2
5x33	6x62	cxcr_on	0	1.385	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	cxcr_off	cxcr4_off
	cxcr_on	cxcr1_on cxcr2_on

Network Difference
Value	cxcr_off	cxcr_on
I_min	3.68	3.62
Number of Linked Nodes	232	261
Number of Specific Nodes	11 (4.74%)	40 (15.33%)
Number of Shared Nodes	221 (95.26%)	221 (84.67%)
Number of Links	270	289
Number of Specific Links	158 (58.52%)	177 (61.25%)
Number of Shared Links	112 (41.48%)	112 (38.75%)
Number of Hubs	34	35
Number of Specific Hubs	20 (58.82%)	21 (60.00%)
Number of Shared Hubs	14 (41.18%)	14 (40.00%)
Average % Shared Neighbours (Jaccard)	25.50
Average % Shared Neighbours (Otsuka)	33.55
Average % Shared Neighbours (Overlap Coefficient)	41.81
Average % Shared Cliques (k3-6)	51.19
Graphlets Similarity	0.605247

Paths Difference
Value	cxcr_off	cxcr_on
Number Of Nodes in MetaPath	63	47
Specific Nodes in MetaPath	42 (66.67%)	26 (55.32%)
Shared Nodes in MetaPath	221 (95.26%)	221 (95.26%)
Number Of Links MetaPath	66	48
Specific Links in MetaPath	57 (86.36%)	39 (81.25%)
Shared Links in MetaPath	112 (41.48%)	112 (41.48%)
Number of Shortest Paths	35141	61598
Length Of Smallest Path	3	3
Average Path Length	12.0647	15.1551
Length of Longest Path	26	32
Minimum Path Strength	1.39	0.665
Average Path Strength	7.65782	6.94544
Maximum Path Strength	41.3533	35.695
Minimum Path Correlation	0.71	0.7
Average Path Correlation	0.95496	0.952554
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	6.25	4
Average % Of Corr. Nodes	61.3693	55.3279
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	47.2684	45.4141
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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