Orange: nodes, hubs and links specific of cxcr_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cxcr_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner cxcr_on_gp Avg Int. Strength cxcr_off Avg Int. Strength cxcr_on_gp Num Of Links cxcr_off Num Of Links ConSurf
1G.s3h2.03 cxcr_on_gp250409
2G.H2.06 cxcr_on_gp250409
3G.H3.09 cxcr_on_gp250409
4G.H3.17 cxcr_on_gp250405
5G.S5.03 cxcr_on_gp00408
6G.S5.05 cxcr_on_gp12.50409
7G.S5.07 cxcr_on_gp12.50409
8G.hgh4.02 cxcr_on_gp250507
9G.hgh4.05 cxcr_on_gp12.50507
10G.H4.03 cxcr_on_gp250404
11G.H4.10 cxcr_on_gp00406
12G.S6.02 cxcr_on_gp00407
13b.1x4 cxcr_on_gp00408
14b.1x11 cxcr_on_gp250408
15b.1x16 cxcr_on_gp00404
16b.h2x1 cxcr_on_gp250405
17b.l1x3 cxcr_on_gp250509
18b.b2x5 cxcr_on_gp250507
19b.l3x2 cxcr_on_gp12.50409
20b.b4x6 cxcr_on_gp250409
21b.b5x2 cxcr_on_gp00407
22b.b5x3 cxcr_on_gp250409
23b.b5x5 cxcr_on_gp250405
24b.l5x1 cxcr_on_gp250408
25b.l5x5 cxcr_on_gp250609
26b.b6x5 cxcr_on_gp250506
27b.b7x1 cxcr_on_gp250404
28b.l7x4 cxcr_on_gp12.50409
29b.b8x4 cxcr_on_gp250406
30b.l9x6 cxcr_on_gp250408
31b.b10x5 cxcr_on_gp250509
32b.b12x6 cxcr_on_gp250408
33b.b13x3 cxcr_on_gp00404
34b.b13x7 cxcr_on_gp250407
35b.l13x3 cxcr_on_gp250409
36b.b16x4 cxcr_on_gp250406
37b.l17x3 cxcr_on_gp250509
38b.l18x1 cxcr_on_gp250506
39b.b19x2 cxcr_on_gp250406
40b.b20x4 cxcr_on_gp250408
41b.b21x1 cxcr_on_gp250407
42b.b21x7 cxcr_on_gp250505
43b.b22x5 cxcr_on_gp250407
44b.l22x5 cxcr_on_gp250409
45b.b23x6 cxcr_on_gp250507
46b.b24x4 cxcr_on_gp250406
47b.l25x3 cxcr_on_gp250409
48b.l27x1 cxcr_on_gp250509
49b.b28x6 cxcr_on_gp250409
50g.ctx6 cxcr_on_gp250406
51g.ctx16 cxcr_on_gp250508
52NT cxcr_on_gp87.516.6667635
531x32 cxcr_on_gp00533
541x47 cxcr_on_gp00426
551x53 cxcr_on_gp00419
561x59 cxcr_on_gp00525
572x38 cxcr_on_gp00436
582x46 cxcr_on_gp500429
592x57 cxcr_on_gp00438
60E1x52 cxcr_on_gp5050637
613x33 cxcr_on_gp500424
623x35 cxcr_on_gp37.566.6667438
633x56 cxcr_on_gp250626
64I2x52 cxcr_on_gp00514
654x42 cxcr_on_gp050538
664x56 cxcr_on_gp00535
674x61 cxcr_on_gp37.50424
684x65 cxcr_on_gp250425
696x30 cxcr_on_gp00426
706x52 cxcr_on_gp37.50438
716x58 cxcr_on_gp00435
727x49 cxcr_on_gp12.50439
737x53 cxcr_on_gp10050539
741x39 Shared5083.3333468
751x60 Shared050445
762x40 Shared2550548
772x42 Shared75100557
782x60 Shared50100475
79E1x50 Shared75100589
803x32 Shared37.5100575
813x37 Shared7550546
823x49 Shared5016.6667448
833x50 Shared250449
843x51 Shared87.583.3333468
85I2x57 Shared2550456
86E2 Shared10010014143
87E2x52 Shared25100453
885x58 Shared1000748
896x48 Shared75100769
906x51 Shared75100646
91E3 Shared62.550672
927x42 Shared75100576
938x50 Shared7550548
94Lig Shared10010016230
951x35 cxcr_off250345
961x50 cxcr_off00349
972x53 cxcr_off2550346
983x36 cxcr_off2550267
993x52 cxcr_off12.550155
1004x50 cxcr_off00349
1015x40 cxcr_off2550343
1025x50 cxcr_off00349
1035x61 cxcr_off00348
1046x44 cxcr_off25100359
1056x62 cxcr_off00352
1067x28 cxcr_off00243
1077x38 cxcr_off050345
   
Orange: nodes, hubs and links specific of cxcr_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cxcr_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner cxcr_on_gp Recurrence cxcr_off Recurrence cxcr_on_gp Hub1? cxcr_off Hub1? cxcr_on_gp Hub2? cxcr_off Hub2? ConSurf1 ConSurf2
16x51 Lig cxcr_on_gp33.74340YesYesYesYes60
26x48 6x51 cxcr_on_gp54.80656.97846YesYesYesYes96
36x48 7x45 cxcr_on_gp60.89862.55787YesYesNoNo99
47x45 7x49 cxcr_on_gp61.72820NoNoYesNo99
52x50 7x49 cxcr_on_gp98.81620NoNoYesNo99
61x53 7x50 cxcr_on_gp99.47270YesNoNoNo99
71x53 8x50 cxcr_on_gp99.3480YesNoYesYes98
81x57 8x50 cxcr_on_gp99.5580NoNoYesYes78
91x57 2x40 cxcr_on_gp99.7265.77239NoNoYesYes78
102x40 8x53 cxcr_on_gp99.87340YesYesNoNo85
111x59 1x60 cxcr_on_gp1002.31331YesNoYesYes55
121x59 8x61 cxcr_on_gp99.58320YesNoNoNo54
138x60 8x61 cxcr_on_gp99.38480NoNoNoNo44
148x60 b.l25x4 cxcr_on_gp99.18650NoNoNoNo45
15b.l25x4 b.l27x2 cxcr_on_gp98.98810NoNoNoNo59
16b.b27x5 b.l27x2 cxcr_on_gp98.59140NoNoNoNo99
17b.b27x5 b.l25x3 cxcr_on_gp98.3930NoNoYesNo99
18b.b28x4 b.l25x3 cxcr_on_gp97.59950NoNoYesNo69
19b.b28x4 b.b28x6 cxcr_on_gp97.00440NoNoYesNo69
20b.b25x7 b.b28x6 cxcr_on_gp96.40930NoNoYesNo79
21b.b25x7 b.lhb1x11 cxcr_on_gp96.01250NoNoNoNo74
22b.lhb1x11 g.ctx5 cxcr_on_gp95.61580NoNoNoNo49
23b.l22x1 g.ctx5 cxcr_on_gp94.22710NoNoNoNo99
24b.l22x1 g.ctx3 cxcr_on_gp94.02880NoNoNoNo99
25g.ctx3 g.ctx6 cxcr_on_gp93.6320NoNoYesNo96
26b.l22x5 g.ctx6 cxcr_on_gp92.24340YesNoYesNo96
27b.l22x5 b.l24x2 cxcr_on_gp90.45810YesNoNoNo96
28b.h2x5 b.l24x2 cxcr_on_gp90.06130NoNoNoNo56
29b.h2x1 b.h2x5 cxcr_on_gp89.66460YesNoNoNo55
30b.b21x5 b.h2x1 cxcr_on_gp86.88740NoNoYesNo45
31b.b21x5 b.b21x7 cxcr_on_gp86.49060NoNoYesNo45
32b.b21x7 b.b24x6 cxcr_on_gp81.9280YesNoNoNo58
33b.b24x4 b.b24x6 cxcr_on_gp81.72970YesNoNoNo68
34b.b23x6 b.b24x4 cxcr_on_gp80.73780YesNoYesNo76
35b.b23x6 b.l23x2 cxcr_on_gp78.95240YesNoNoNo78
36b.l21x7 b.l23x2 cxcr_on_gp78.15890NoNoNoNo58
37b.l21x7 b.l23x1 cxcr_on_gp77.96060NoNoNoNo56
38b.l23x1 b.l25x6 cxcr_on_gp77.56380NoNoNoNo68
39b.l25x6 b.l27x1 cxcr_on_gp77.36550NoNoYesNo89
40b.b2x1 b.l27x1 cxcr_on_gp63.08260NoNoYesNo89
41b.b2x1 b.l3x1 cxcr_on_gp62.68590NoNoNoNo89
42b.l3x1 b.l5x5 cxcr_on_gp62.48750NoNoYesNo99
437x38 7x42 cxcr_on_gp19.37856.90308NoYesYesYes56
447x49 7x53 cxcr_on_gp45.10240YesNoYesNo99
453x47 5x58 cxcr_on_gp17.69070.671714NoNoYesYes98
463x50 5x58 cxcr_on_gp18.56310YesYesYesYes98
473x50 7x53 cxcr_on_gp17.01680YesYesYesNo99
485x58 6x40 cxcr_on_gp17.46390YesYesNoNo88
496x40 7x53 cxcr_on_gp18.40280NoNoYesNo89
505x54 6x44 cxcr_on_gp11.31570NoNoNoYes89
516x44 6x48 cxcr_on_gp12.46719.34035NoYesYesYes99
523x47 5x57 cxcr_on_gp21.80360NoNoNoNo97
533x51 5x57 cxcr_on_gp20.05891.19937YesYesNoNo87
543x51 3x56 cxcr_on_gp13.86411.15582YesYesYesNo86
555x58 5x61 cxcr_on_gp14.31260YesYesNoYes88
565x65 6x30 cxcr_on_gp10.55320NoNoYesNo86
575x61 5x65 cxcr_on_gp12.3340.800697NoYesNoNo88
58G.h2s4.01 b.l5x5 cxcr_on_gp17.65520NoNoYesNo99
59G.S1.05 G.h2s4.01 cxcr_on_gp17.45680NoNoNoNo99
60G.S1.05 G.S1.07 cxcr_on_gp17.06010NoNoNoNo99
61G.H3.12 G.S1.07 cxcr_on_gp16.86170NoNoNoNo89
62G.H2.04 G.H3.12 cxcr_on_gp16.66330NoNoNoNo98
63G.H2.04 G.H3.08 cxcr_on_gp16.26660NoNoNoNo99
64G.H3.08 G.S4.04 cxcr_on_gp16.06820NoNoNoNo99
65G.H3.09 G.S4.04 cxcr_on_gp15.86980YesNoNoNo99
66b.b26x1 b.l27x1 cxcr_on_gp11.7040NoNoYesNo99
67b.b26x1 b.b26x2 cxcr_on_gp11.50560NoNoNoNo97
68b.b26x2 b.b2x3 cxcr_on_gp11.30730NoNoNoNo76
69b.b2x3 b.b2x5 cxcr_on_gp11.10890NoNoYesNo67
70b.l5x5 b.l7x2 cxcr_on_gp37.49250YesNoNoNo99
71G.s3h2.03 b.l7x2 cxcr_on_gp37.29410YesNoNoNo99
72G.s3h2.03 b.l9x6 cxcr_on_gp35.50880YesNoYesNo98
73b.l11x1 b.l9x6 cxcr_on_gp32.33480NoNoYesNo98
74b.b11x6 b.l11x1 cxcr_on_gp32.13640NoNoNoNo99
75b.b11x6 b.l9x3 cxcr_on_gp30.74780NoNoNoNo99
76b.b11x4 b.l9x3 cxcr_on_gp30.15270NoNoNoNo99
77b.b10x3 b.b11x4 cxcr_on_gp24.20150NoNoNoNo89
78b.b10x3 b.b6x2 cxcr_on_gp23.80480NoNoNoNo88
79b.b10x2 b.b6x2 cxcr_on_gp23.60640NoNoNoNo68
80b.b10x2 b.b14x3 cxcr_on_gp22.01940NoNoNoNo65
81b.b11x5 b.b14x3 cxcr_on_gp21.8210NoNoNoNo65
82b.b11x5 b.l13x7 cxcr_on_gp21.42430NoNoNoNo69
83b.l13x3 b.l13x7 cxcr_on_gp21.02750YesNoNoNo99
84b.b16x4 b.l13x3 cxcr_on_gp19.63890YesNoYesNo69
85b.b16x4 b.b17x6 cxcr_on_gp15.07630YesNoNoNo67
86b.b17x6 g.h1x14 cxcr_on_gp14.8780NoNoNoNo79
87b.1x15 g.h1x14 cxcr_on_gp14.67960NoNoNoNo79
881x50 2x50 Shared98.9881100NoYesNoNo99
891x50 7x50 Shared99.236294.5124NoYesNoNo99
901x60 8x53 Shared99.90770.6489YesYesNoNo55
916x51 7x38 Shared18.658715.1529YesYesNoYes65
922x42 3x46 Shared11.206520.6573YesYesNoNo79
932x53 3x35 Shared13.329150.7069NoYesYesNo68
94E2 Lig Shared12.704315.9017YesYesYesYes30
957x32 7x33 cxcr_off011.4158NoNoNoNo25
967x33 7x37 cxcr_off0.56862612.9468NoNoNoNo57
976x51 7x37 cxcr_off1.8738819.0375YesYesNoNo67
983x32 6x48 cxcr_off018.0927YesYesYesYes59
992x53 3x32 cxcr_off7.4767955.7841NoYesYesYes65
1002x50 3x35 cxcr_off050.4221NoNoYesNo98
1012x53 7x42 cxcr_off6.8648745.638NoYesYesYes66
1022x53 7x46 cxcr_off050.6315NoYesNoNo68
1032x50 7x46 cxcr_off0.62484250.3467NoNoNoNo98
1047x49 7x50 cxcr_off090.4921YesNoNoNo99
1052x43 7x49 cxcr_off079.6459NoNoYesNo89
1062x43 7x53 cxcr_off079.0613NoNoYesNo89
1077x53 8x50 cxcr_off074.1248YesNoYesYes98
1088x50 8x53 cxcr_off071.9153YesYesNoNo85
1091x60 2x40 cxcr_off064.0792YesYesYesYes58
1102x37 2x40 cxcr_off0.62484252.841NoNoYesYes78
1112x37 2x39 cxcr_off049.2295NoNoNoNo78
1122x39 3x46 cxcr_off021.9438NoNoNoNo89
1132x39 3x50 cxcr_off026.5336NoNoYesYes89
1143x50 3x53 cxcr_off021.8634YesYesNoNo98
1153x53 I2x57 cxcr_off0.90398620.8382NoNoYesYes86
1162x42 4x45 cxcr_off0.56410313.1679YesYesNoNo75
1172x45 4x45 cxcr_off012.4058NoNoNoNo95
1182x45 4x50 cxcr_off2.064510.1427NoNoNoYes99
1192x46 7x49 cxcr_off3.5778213.6872YesNoYesNo99
1202x46 3x42 cxcr_off2.3216712.5649YesNoNoNo98
1213x42 4x49 cxcr_off1.5488611.4392NoNoNoNo87
1223x41 4x49 cxcr_off0.77475310.3102NoNoNoNo67
1233x52 I2x57 cxcr_off018.9001NoYesYesYes56
1243x51 3x52 cxcr_off011.4577YesYesNoYes85
1257x42 Lig cxcr_off026.1684YesYesYesYes60
1263x32 Lig cxcr_off9.6627728.8217YesYesYesYes50

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
1x351x39Shared8.011675.9951011
1x35Ligcxcr_off2.9401010
1x392x60cxcr_off4.3416701111
1x39Ligcxcr_off7.8901110
2x533x32Shared3.196.1651121
2x537x42Shared103.86751121
2x562x60Shared3.033333.486250021
2x577x42Shared3.361673.868750121
2x60E1x50cxcr_off4.21501112
2x603x28Shared3.171672.811112
2x607x42cxcr_off5.2501111
2x60LigShared17.113313.1651110
2x63E1x50Shared7.816676.74751112
E1x49E2Shared12.28333.91751121
E1x50E2Shared5.036674.15251121
3x22E2Shared7.1956.676251021
3x294x65Shared4.513338.151112
3x29Ligcxcr_off4.3033301110
3x326x48cxcr_off3.1466701112
3x327x38cxcr_off3.7516701111
3x327x42Shared7.048333.741111
3x32LigShared5.503337.578751110
3x333x36cxcr_off3.0200022
3x334x61Shared10.00838.19250022
3x366x48Shared6.277.051251022
3x366x52cxcr_off4.7201022
4x61E2x52Shared8.2359.720121
4x64E2Shared20.56338.246251121
4x65E2x52Shared8.318.303750121
E2E2Shared44.340.9751111
E2E2x51Shared12.2758.39251111
E2E2x52Shared11.56.386251111
5x36E2x52cxcr_off3.601111
5x35E2Shared14.001711.82371121
5x36E2cxcr_off6.9133301111
5x406x58Shared4.823336.5151011
5x406x59Shared4.6255.276251012
5x406x62cxcr_off4.76501011
6x486x51Shared6.271673.493751121
6x516x55Shared7.788337.5350112
6x517x37Shared6.451674.9950112
6x517x38Shared7.523336.246250111
6x547x34Shared3.7453.061250021
6x586x62Shared3.551674.106251111
6x62E3cxcr_off3.57501112
7x27E3Shared3.493.343751112
7x277x31cxcr_off4.4816701111
7x34LigShared3.651674.278751110
7x35LigShared9.528333.5450010
7x38LigShared8.943339.27751110
7x42Ligcxcr_off14.11501110
LigNTShared13.921741.12751101
1x247x28cxcr_off3.2133301012
1x24Ligcxcr_off2.9533301010
1x397x42Shared2.923335.91751111
2x603x32Shared4.341679.213751111
2x63Ligcxcr_off6.2283301110
3x323x36cxcr_off4.6901112
4x645x35cxcr_off3.5083301122
E2LigShared15.858331.74251110
E2x51LigShared4.4616711.5451110
5x34E2cxcr_off2.97500021
6x58LigShared4.874.453751110
6x62LigShared3.4355.573751110
6x64E3cxcr_off3.37500012
7x27LigShared4.5633313.37621110
7x31Ligcxcr_off2.9733301010
7x387x42Shared3.303337.738751111
E2x52Ligcxcr_off5.58501110
5x40Ligcxcr_off3.7501010
5x39E2Shared2.751673.703751121
1x392x61Shared2.668333.66751112
7x24NTShared2.426677.05250021
1x311x35Shared2.288334.006250021
1x397x39cxcr_off2.2233301112
1x277x28cxcr_off2.0433300022
1x352x64Shared1.841673.081012
1x25NTcxcr_off1.55500021
5x32E2Shared1.4453.823750021
5x33Ligcxcr_off1.30500010
5x376x62Shared1.221675.460021
NTNTcxcr_on_gp024.84621111
1x277x31cxcr_on_gp04.4750021
1x392x57cxcr_on_gp04.688751112
2x63E2cxcr_on_gp04.44751111
3x294x61cxcr_on_gp03.866251112
3x323x33cxcr_on_gp03.466251112
4x614x65cxcr_on_gp04.46250122
5x39E2x52cxcr_on_gp03.881251121
5x36Ligcxcr_on_gp06.058751110
5x376x59cxcr_on_gp04.03750022
5x406x55cxcr_on_gp07.71012
6x486x52cxcr_on_gp03.528751122
6x516x52cxcr_on_gp05.631250112
6x51Ligcxcr_on_gp04.4850110
E3E3cxcr_on_gp03.833750122
7x28NTcxcr_on_gp06.12250121
5x36E2x51cxcr_on_gp06.9451111
5x315x34cxcr_on_gp04.12250122
1x247x31cxcr_on_gp03.951011
6x64Ligcxcr_on_gp02.91250010
6x587x30cxcr_on_gp02.67751112
1x32NTcxcr_on_gp02.36250121
5x335x36cxcr_on_gp02.336250011
5x31E2cxcr_on_gp01.36250121

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
cxcr_on_gp cxcr3_on_gp
cxcr4_on_gp
cxcr1_on_gp
cxcr2_on_gp
cxcr_off cxcr3_off
cxcr4_off
Network Difference
Value cxcr_on_gp cxcr_off
Imin 3.425 2.90833
Number of Linked Nodes 866 263
Number of Specific Nodes 603 (69.63%) 0  (0.00%)
Number of Shared Nodes 263 (30.37%) 263  (100.00%)
Number of Links 895 302
Number of Specific Links 723 (80.78%) 130  (43.05%)
Number of Shared Links 172 (19.22%) 172  (56.95%)
Number of Hubs 94 34
Number of Specific Hubs 73 (77.66%) 13  (38.24%)
Number of Shared Hubs 21 (22.34%) 21  (61.76%)
Average % Shared Neighbours (Jaccard) 13.28
Average % Shared Neighbours (Otsuka) 16.40
Average % Shared Neighbours (Overlap Coefficient) 19.68
Average % Shared Cliques (k3-6) 54.07
Graphlets Similarity 0.618603
Paths Difference
Value cxcr_on_gp cxcr_off
Number Of Nodes in MetaPath 96 39
Specific Nodes in MetaPath 75 (78.13%) 18  (46.15%)
Shared Nodes in MetaPath 263 (30.37%) 263  (30.37%)
Number Of Links MetaPath 94 39
Specific Links in MetaPath 87 (92.55%) 32  (82.05%)
Shared Links in MetaPath 172 (19.22%) 172  (19.22%)
Number of Shortest Paths 225327 80138
Length Of Smallest Path 3 3
Average Path Length 41.5956 16.7218
Length of Longest Path 84 34
Minimum Path Strength 0.686875 0.728889
Average Path Strength 3.67842 5.57351
Maximum Path Strength 28.2312 18.2108
Minimum Path Correlation 0.70375 0.7
Average Path Correlation 0.925861 0.90409
Maximum Path Correlation 0.99 0.986667
Minimum % Of Corr. Nodes 1.2987 3.57143
Average % Of Corr. Nodes 19.7582 32.1806
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 38.952 41.023
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

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