psnGPCR

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Orange: nodes, hubs and links specific of d2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of d2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	d2_off Int. Strength	d2_on Int. Strength	d2_off Hub1?	d2_on Hub1?	d2_off Hub2?	d2_on Hub2?	ConSurf1	ConSurf2
1	1x53	2x47	d2_off	100	0	No	No	No	No	9	9
2	1x53	7x50	d2_off	100	0	No	No	No	No	9	9
3	1x53	7x53	d2_off	100	0	No	No	Yes	Yes	9	9
4	2x38	4x42	d2_off	100	0	No	No	No	No	7	7
5	2x39	3x50	d2_off	100	0	No	No	Yes	No	8	9
6	2x42	3x46	d2_off	100	0	No	No	No	No	8	9
7	2x46	3x39	d2_off	100	0	No	Yes	No	No	9	9
8	2x53	2x57	d2_off	100	0	No	No	No	No	8	9
9	2x53	3x35	d2_off	100	0	No	No	No	No	8	7
10	2x59	E1x52	d2_off	100	0	No	No	Yes	Yes	6	7
11	2x60	Lig	d2_off	100	0	No	No	Yes	Yes	8	0
12	2x63	Lig	d2_off	100	0	No	No	Yes	Yes	7	0
13	3x21	3x23	d2_off	100	0	No	No	No	No	8	4
14	3x21	3x24	d2_off	100	0	No	No	Yes	No	8	6
15	3x29	E2x51	d2_off	100	0	No	No	Yes	No	6	5
16	3x29	5x39	d2_off	100	0	No	No	Yes	Yes	6	8
17	3x38	4x53	d2_off	100	0	No	No	No	No	8	8
18	3x39	6x44	d2_off	100	0	No	No	Yes	Yes	9	9
19	3x41	5x50	d2_off	100	0	No	No	No	No	8	9
20	3x44	5x54	d2_off	100	0	No	No	No	No	7	9
21	3x47	5x57	d2_off	100	0	No	No	No	No	9	7
22	3x50	3x53	d2_off	100	0	Yes	No	No	No	9	8
23	3x50	6x30	d2_off	100	0	Yes	No	No	No	9	9
24	3x50	6x34	d2_off	100	0	Yes	No	No	No	9	8
25	3x50	6x37	d2_off	100	0	Yes	No	No	No	9	8
26	3x53	6x30	d2_off	100	0	No	No	No	No	8	9
27	4x36	4x40	d2_off	100	0	No	No	No	No	8	6
28	4x39	4x42	d2_off	100	0	Yes	No	No	No	6	7
29	4x39	4x43	d2_off	100	0	Yes	No	No	No	6	5
30	4x41	4x45	d2_off	100	0	No	No	No	No	8	8
31	4x52	4x56	d2_off	100	0	No	No	No	No	7	8
32	4x56	5x42	d2_off	100	0	No	No	Yes	No	8	7
33	4x60	5x42	d2_off	100	0	No	No	Yes	No	8	7
34	4x62	4x63	d2_off	100	0	No	No	No	No	7	6
35	E2.L174	E2x51	d2_off	100	0	No	No	Yes	No	7	5
36	5x42	E2.L174	d2_off	100	0	Yes	No	No	No	7	7
37	5x36	E2.D178	d2_off	100	0	Yes	No	No	No	7	3
38	E2.A185	E2.E181	d2_off	100	0	No	No	No	No	7	4
39	5x39	E2x52	d2_off	100	0	Yes	Yes	No	No	8	7
40	5x36	5x37	d2_off	100	0	Yes	No	No	No	7	4
41	5x36	5x38	d2_off	100	0	Yes	No	No	No	7	5
42	5x42	5x46	d2_off	100	0	Yes	No	No	No	7	6
43	5x47	Lig	d2_off	100	0	Yes	Yes	Yes	Yes	9	0
44	5x58	6x38	d2_off	100	0	Yes	Yes	No	No	9	8
45	5x67	5x70	d2_off	100	0	No	No	No	No	6	7
46	5x67	5x71	d2_off	100	0	No	No	No	No	6	6
47	5x68	6x28	d2_off	100	0	No	No	No	No	8	6
48	6x32	6x35	d2_off	100	0	No	No	No	No	9	8
49	6x40	7x49	d2_off	100	0	No	No	No	No	9	9
50	6x40	7x52	d2_off	100	0	No	No	No	No	9	8
51	6x44	7x45	d2_off	100	0	Yes	Yes	Yes	Yes	9	9
52	6x45	6x49	d2_off	100	0	No	No	No	No	7	7
53	6x48	6x51	d2_off	100	0	Yes	Yes	Yes	Yes	9	8
54	6x48	7x42	d2_off	100	0	Yes	Yes	Yes	Yes	9	8
55	6x48	Lig	d2_off	100	0	Yes	Yes	Yes	Yes	9	0
56	6x54	7x34	d2_off	100	0	No	No	Yes	No	5	5
57	6x55	7x34	d2_off	100	0	No	No	Yes	No	8	5
58	6x57	E3.I403	d2_off	100	0	No	No	Yes	No	7	6
59	7x45	7x48	d2_off	100	0	Yes	Yes	No	No	9	7
60	7x49	7x53	d2_off	100	0	No	No	Yes	Yes	9	9
61	7x53	8x50	d2_off	100	0	Yes	Yes	Yes	Yes	9	9
62	7x55	7x56	d2_off	100	0	No	No	Yes	No	7	8
63	8x47	8x49	d2_off	100	0	No	No	Yes	No	9	7
64	8x48	8x49	d2_off	100	0	No	No	Yes	No	5	7
65	8x48	8x51	d2_off	100	0	No	No	No	No	5	9
66	8x52	8x56	d2_off	100	0	No	No	No	No	6	7
67	1x33	1x35	d2_off	100	0	No	No	Yes	No	7	5
68	1x59	1x60	d2_off	100	0	No	No	Yes	No	7	8
69	3x26	E2.Q179	d2_off	100	0	Yes	No	No	No	6	1
70	3x37	4x53	d2_off	100	0	No	No	No	No	8	8
71	6x29	6x30	d2_off	100	0	No	No	No	No	7	9
72	7x39	7x42	d2_off	100	0	Yes	Yes	Yes	Yes	8	8
73	6x59	6x60	d2_off	100	0	No	No	No	No	6	6
74	3x54	5x65	d2_off	66.6667	0	No	No	No	No	8	8
75	5x52	5x56	d2_off	0	0	No	No	No	No	4	5
76	5x36	E2x51	d2_off	66.6667	0	Yes	No	Yes	No	7	5
77	5x58	5x61	d2_off	33.3333	0	Yes	Yes	No	Yes	9	9
78	5x65	6x31	d2_off	33.3333	0	No	No	No	No	8	7
79	6x36	8x47	d2_off	33.3333	0	No	No	No	No	9	9
80	1x56	8x54	d2_off	0	0	No	No	No	No	9	9
81	1x57	8x50	d2_off	0	0	No	No	Yes	Yes	8	9
82	3x26	E2x50	d2_off	66.6667	0	Yes	No	No	No	6	9
83	8x55	8x59	d2_off	66.6667	0	No	No	No	No	5	5
84	8x58	8x59	d2_off	33.3333	0	No	No	No	No	8	5
85	6x32	7x56	d2_off	66.6667	0	No	No	Yes	No	9	8
86	4x52	4x55	d2_off	33.3333	0	No	No	No	No	7	5
87	2x66	E1x49	d2_off	33.3333	0	Yes	No	No	No	5	4
88	1x54	2x44	d2_off	33.3333	0	No	No	No	No	7	7
89	1x35	7x39	d2_off	33.3333	0	Yes	No	Yes	Yes	5	8
90	1x34	1x35	d2_off	33.3333	0	No	No	Yes	No	5	5
91	3x23	3x27	d2_off	0	0	No	No	No	No	4	6
92	6x28	6x31	d2_off	33.3333	0	No	No	No	No	6	7
93	6x26	I2x50	d2_off	33.3333	0	No	No	No	No	6	9
94	1x43	2x58	d2_off	33.3333	0	No	No	No	No	8	9
95	4x64	E2.D178	d2_off	33.3333	0	No	No	No	No	7	3
96	8x51	8x55	d2_off	0	0	No	No	No	No	9	5
97	4x34	4x38	d2_off	33.3333	0	No	No	No	No	7	6
98	E3.C401	E3.D400	d2_off	33.3333	0	No	No	No	No	7	3
99	1x55	1x58	d2_off	33.3333	0	No	No	No	No	5	6
100	1x37	1x41	d2_off	33.3333	0	No	No	No	No	6	6
101	5x66	5x69	d2_off	33.3333	0	No	No	No	No	6	6
102	3x50	6x33	d2_off	0	0	Yes	No	No	No	9	9
103	4x35	4x39	d2_off	33.3333	0	No	No	Yes	No	7	6
104	E3.C401	E3.I403	d2_off	33.3333	0	No	No	Yes	No	7	6
105	1x40	2x61	d2_off	33.3333	0	No	No	No	No	4	8
106	5x45	5x49	d2_off	0	0	No	No	No	No	6	8
107	E2.A177	E2.E181	d2_off	33.3333	0	No	No	No	No	4	4
108	5x60	5x63	d2_off	0	0	No	No	No	No	7	5
109	3x56	I2x51	d2_off	0	0	No	No	No	No	6	0
110	3x51	3x56	d2_off	0	0	Yes	Yes	No	No	8	6
111	1x34	1x38	d2_off	0	0	No	No	No	No	5	5
112	6x46	6x47	d2_off	0	0	No	No	No	No	5	9
113	1x41	1x44	d2_off	0	0	No	No	No	No	6	5
114	1x37	1x40	d2_off	0	0	No	No	No	No	6	4
115	5x56	5x59	d2_off	0	0	No	No	No	No	5	4
116	1x39	2x61	Shared	100	100	No	No	No	No	7	8
117	1x39	7x39	Shared	100	100	No	No	Yes	Yes	7	8
118	1x42	1x46	Shared	100	100	No	No	Yes	Yes	7	8
119	1x43	2x57	Shared	100	100	No	No	No	No	8	9
120	1x46	2x54	Shared	100	50	Yes	Yes	No	No	8	8
121	1x46	7x46	Shared	100	50	Yes	Yes	No	No	8	9
122	1x47	2x51	Shared	100	50	No	No	No	No	7	8
123	1x48	1x49	Shared	100	100	No	No	No	No	5	9
124	1x49	7x50	Shared	100	100	No	No	No	No	9	9
125	1x50	2x47	Shared	100	100	Yes	Yes	No	No	9	9
126	1x50	2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
127	1x50	2x51	Shared	100	100	Yes	Yes	No	No	9	8
128	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
129	1x52	8x54	Shared	100	50	No	Yes	No	No	8	9
130	1x57	2x44	Shared	100	100	No	No	No	No	8	7
131	1x59	8x57	Shared	100	100	No	No	No	No	7	8
132	1x60	I1x50	Shared	100	100	Yes	No	No	Yes	8	9
133	1x60	8x53	Shared	100	0	Yes	No	No	No	8	9
134	I1x48	I1x51	Shared	100	50	No	No	No	No	8	8
135	8x49	I1x50	Shared	100	0	Yes	No	No	Yes	7	9
136	8x50	I1x50	Shared	100	100	Yes	Yes	No	Yes	9	9
137	2x41	I1x51	Shared	100	100	No	No	No	No	7	8
138	2x37	2x40	Shared	100	100	No	No	No	No	8	9
139	2x38	3x49	Shared	100	100	No	No	Yes	Yes	7	8
140	2x39	3x49	Shared	100	100	No	No	Yes	Yes	8	8
141	2x40	8x50	Shared	100	100	No	No	Yes	Yes	9	9
142	2x42	3x45	Shared	100	0	No	No	No	No	8	7
143	2x42	3x49	Shared	100	100	No	No	Yes	Yes	8	8
144	2x43	7x53	Shared	100	100	No	No	Yes	Yes	8	9
145	2x45	3x42	Shared	100	100	No	No	No	No	9	8
146	2x45	4x46	Shared	100	100	No	No	No	No	9	9
147	2x45	4x50	Shared	100	100	No	No	No	No	9	9
148	2x46	3x42	Shared	100	100	No	Yes	No	No	9	8
149	2x50	3x39	Shared	100	100	No	Yes	No	No	9	9
150	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
151	2x52	2x551	Shared	100	100	No	No	No	No	7	5
152	2x52	3x35	Shared	100	100	No	No	No	No	7	7
153	2x55	2x551	Shared	100	0	No	No	No	No	6	5
154	2x56	3x32	Shared	100	100	No	No	No	No	8	8
155	2x57	7x42	Shared	100	100	No	No	Yes	Yes	9	8
156	2x59	3x24	Shared	100	100	No	No	Yes	No	6	6
157	2x59	3x28	Shared	100	100	No	No	No	No	6	7
158	2x60	7x39	Shared	100	100	No	No	Yes	Yes	8	8
159	2x60	7x42	Shared	100	100	No	No	Yes	Yes	8	8
160	2x62	2x66	Shared	100	100	No	No	Yes	No	6	5
161	2x62	E1x52	Shared	100	50	No	No	Yes	Yes	6	7
162	2x63	E1x50	Shared	100	50	No	No	Yes	Yes	7	9
163	2x64	7x39	Shared	100	100	No	No	Yes	Yes	7	8
164	E1x49	E1x51	Shared	100	100	No	No	No	No	4	4
165	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	9	7
166	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	9
167	3x28	E1x50	Shared	100	100	No	No	Yes	Yes	7	9
168	3x24	E1x52	Shared	100	100	Yes	No	Yes	Yes	6	7
169	3x22	3x26	Shared	100	0	No	No	Yes	No	3	6
170	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
171	3x30	4x61	Shared	100	50	No	No	No	Yes	8	8
172	3x30	4x62	Shared	100	100	No	No	No	No	8	7
173	3x32	7x42	Shared	100	100	No	No	Yes	Yes	8	8
174	3x32	Lig	Shared	100	100	No	No	Yes	Yes	8	0
175	3x33	4x61	Shared	100	100	No	No	No	Yes	8	8
176	3x33	Lig	Shared	100	100	No	No	Yes	Yes	8	0
177	3x34	4x57	Shared	100	100	No	Yes	No	No	7	9
178	3x36	Lig	Shared	100	100	No	No	Yes	Yes	8	0
179	3x37	5x461	Shared	100	100	No	No	No	No	8	8
180	3x38	4x50	Shared	100	100	No	No	No	No	8	9
181	3x40	5x50	Shared	100	50	No	No	No	No	9	9
182	3x40	6x44	Shared	100	100	No	No	Yes	Yes	9	9
183	3x41	4x49	Shared	100	100	No	No	No	No	8	9
184	3x41	4x52	Shared	100	100	No	No	No	No	8	7
185	3x42	4x49	Shared	100	100	No	No	No	No	8	9
186	3x43	6x44	Shared	100	100	No	No	Yes	Yes	8	9
187	3x47	5x54	Shared	100	100	No	No	No	No	9	9
188	3x47	5x58	Shared	100	100	No	No	Yes	Yes	9	9
189	3x49	4x41	Shared	100	100	Yes	Yes	No	No	8	8
190	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	8
191	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	7
192	3x51	5x61	Shared	100	100	Yes	Yes	No	Yes	8	9
193	3x52	4x41	Shared	100	100	No	No	No	No	6	8
194	3x54	5x64	Shared	100	100	No	No	No	No	8	7
195	4x34	4x37	Shared	100	100	No	No	No	No	7	8
196	4x54	4x59	Shared	100	50	No	No	No	No	6	6
197	4x56	5x46	Shared	100	100	No	No	No	No	8	6
198	4x61	5x39	Shared	100	100	No	Yes	Yes	Yes	8	8
199	E2x52	Lig	Shared	100	100	No	No	Yes	Yes	7	0
200	5x39	5x43	Shared	100	100	Yes	Yes	No	No	8	9
201	5x40	6x55	Shared	100	100	No	No	No	No	7	8
202	5x44	6x52	Shared	100	100	No	No	Yes	Yes	8	8
203	5x461	Lig	Shared	100	100	No	No	Yes	Yes	8	0
204	5x47	5x48	Shared	100	100	Yes	Yes	No	No	9	7
205	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	9	8
206	5x48	6x56	Shared	100	100	No	No	No	No	7	7
207	5x49	5x50	Shared	100	50	No	No	No	No	8	9
208	5x51	6x45	Shared	100	100	No	Yes	No	No	7	7
209	5x55	5x59	Shared	100	50	No	No	No	No	6	4
210	5x58	6x41	Shared	100	100	Yes	Yes	No	No	9	8
211	5x66	5x70	Shared	100	100	No	No	No	No	6	7
212	6x36	7x56	Shared	100	100	No	No	Yes	No	9	8
213	6x39	7x56	Shared	100	0	No	No	Yes	No	8	8
214	6x43	7x52	Shared	100	50	No	No	No	No	7	8
215	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	9
216	6x47	7x45	Shared	100	100	No	No	Yes	Yes	9	9
217	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	9	8
218	6x48	7x41	Shared	100	100	Yes	Yes	No	No	9	8
219	6x49	6x53	Shared	100	100	No	No	No	No	7	7
220	6x50	7x37	Shared	100	100	No	No	No	No	9	5
221	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	8
222	6x51	6x55	Shared	100	100	Yes	Yes	No	No	8	8
223	6x51	7x38	Shared	100	100	Yes	Yes	No	No	8	8
224	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
225	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
226	6x54	7x37	Shared	100	100	No	No	No	No	5	5
227	6x58	E3.I403	Shared	100	100	No	No	Yes	No	5	6
228	6x58	7x34	Shared	100	100	No	No	Yes	No	5	5
229	6x61	E3.C401	Shared	100	100	No	No	No	No	6	7
230	7x30	E3.I403	Shared	100	100	Yes	Yes	Yes	No	6	6
231	7x30	7x33	Shared	100	100	Yes	Yes	No	No	6	6
232	7x34	Lig	Shared	100	100	Yes	No	Yes	Yes	5	0
233	7x38	7x42	Shared	100	100	No	No	Yes	Yes	8	8
234	7x38	Lig	Shared	100	100	No	No	Yes	Yes	8	0
235	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
236	7x54	8x54	Shared	100	100	No	No	No	No	8	9
237	8x47	8x50	Shared	100	100	No	No	Yes	Yes	9	9
238	8x48	8x52	Shared	100	0	No	No	No	No	5	6
239	1x60	8x56	Shared	100	100	Yes	No	No	No	8	7
240	2x64	7x35	Shared	100	100	No	No	No	No	7	6
241	3x24	E1x50	Shared	100	100	Yes	No	Yes	Yes	6	9
242	6x56	6x60	Shared	100	100	No	No	No	No	7	6
243	7x45	7x49	Shared	100	100	Yes	Yes	No	No	9	9
244	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	9	9
245	1x51	2x51	Shared	33.3333	0	No	No	No	No	6	8
246	1x52	8x57	Shared	33.3333	50	No	Yes	No	No	8	8
247	3x44	5x53	Shared	66.6667	50	No	No	No	No	7	8
248	E2.E181	E2x51	Shared	33.3333	50	No	No	Yes	No	4	5
249	1x46	7x47	Shared	66.6667	0	Yes	Yes	No	No	8	7
250	3x26	E2.N175	Shared	33.3333	50	Yes	No	No	Yes	6	7
251	2x49	4x50	Shared	0	0	No	No	No	No	8	9
252	4x42	4x46	Shared	33.3333	0	No	No	No	No	7	9
253	4x44	4x48	Shared	66.6667	0	No	No	No	No	3	4
254	5x41	5x45	Shared	66.6667	0	No	No	No	No	7	6
255	5x58	6x37	Shared	33.3333	50	Yes	Yes	No	No	9	8
256	1x51	1x55	Shared	33.3333	0	No	No	No	No	6	5
257	2x48	2x52	Shared	0	0	No	No	No	No	7	7
258	5x47	6x49	Shared	0	50	Yes	Yes	No	No	9	7
259	3x48	4x45	Shared	0	0	No	No	No	No	7	8
260	3x34	3x35	Shared	0	50	No	Yes	No	No	7	7
261	2x41	4x39	Shared	66.6667	50	No	No	Yes	No	7	6
262	2x551	3x31	Shared	0	50	No	No	No	No	5	6
263	1x45	7x47	Shared	33.3333	50	No	No	No	No	5	7
264	3x56	I2x50	Shared	33.3333	0	No	No	No	No	6	9
265	6x50	7x40	Shared	33.3333	0	No	No	No	No	9	8
266	2x38	4x38	Shared	66.6667	100	No	No	No	No	7	6
267	3x34	4x54	Shared	33.3333	100	No	Yes	No	No	7	6
268	1x42	7x43	Shared	0	0	No	No	No	No	7	6
269	5x59	5x63	Shared	0	0	No	No	No	No	4	5
270	7x30	7x31	Shared	0	0	Yes	Yes	No	No	6	3
271	5x61	5x65	Shared	0	0	No	Yes	No	No	9	8
272	5x36	E2.N176	Shared	33.3333	50	Yes	No	No	No	7	7
273	6x27	6x31	Shared	33.3333	50	No	No	No	No	5	7
274	5x68	5x71	Shared	33.3333	0	No	No	No	No	8	6
275	1x36	2x65	Shared	0	0	No	No	No	No	7	6
276	4x43	4x47	Shared	0	0	No	No	No	No	5	5
277	4x51	4x55	Shared	0	0	No	No	No	No	5	5
278	8x49	I1x49	Shared	33.3333	100	Yes	No	No	No	7	7
279	E1x49	E2.N180	Shared	33.3333	50	No	No	No	No	4	3
280	7x30	7x32	Shared	33.3333	0	Yes	Yes	No	No	6	4
281	2x65	2x66	Shared	33.3333	0	No	No	Yes	No	6	5
282	5x62	5x66	Shared	0	100	No	No	No	No	7	6
283	7x51	7x55	Shared	0	100	No	No	No	No	7	7
284	1x35	1x38	Shared	0	50	Yes	No	No	No	5	5
285	2x66	2x67	Shared	0	0	Yes	No	No	No	5	5
286	6x41	6x42	Shared	0	0	No	No	No	No	8	7
287	4x36	4x37	Shared	0	0	No	No	No	No	8	8
288	1x48	1x52	d2_on	0	100	No	No	No	Yes	5	8
289	1x53	7x54	d2_on	0	100	No	No	No	No	9	8
290	2x37	I2x53	d2_on	0	100	No	No	No	Yes	8	0
291	2x38	I2x53	d2_on	0	100	No	No	No	Yes	7	0
292	2x39	I2x53	d2_on	0	100	No	No	No	Yes	8	0
293	2x46	2x50	d2_on	0	100	No	Yes	No	Yes	9	9
294	2x46	3x43	d2_on	0	100	No	Yes	No	No	9	8
295	2x46	7x49	d2_on	0	100	No	Yes	No	No	9	9
296	2x50	7x49	d2_on	0	100	No	Yes	No	No	9	9
297	2x61	7x39	d2_on	0	100	No	No	Yes	Yes	8	8
298	3x29	4x61	d2_on	0	100	No	No	No	Yes	6	8
299	3x29	E2x52	d2_on	0	100	No	No	No	No	6	7
300	3x33	4x57	d2_on	0	100	No	No	No	No	8	9
301	3x34	4x53	d2_on	0	100	No	Yes	No	No	7	8
302	3x36	6x48	d2_on	0	100	No	No	Yes	Yes	8	9
303	3x40	6x48	d2_on	0	100	No	No	Yes	Yes	9	9
304	3x43	7x53	d2_on	0	100	No	No	Yes	Yes	8	9
305	3x44	5x50	d2_on	0	100	No	No	No	No	7	9
306	3x46	3x50	d2_on	0	100	No	No	Yes	No	9	9
307	3x49	I2x53	d2_on	0	100	Yes	Yes	No	Yes	8	0
308	3x50	5x58	d2_on	0	100	Yes	No	Yes	Yes	9	9
309	3x50	7x53	d2_on	0	100	Yes	No	Yes	Yes	9	9
310	3x53	I2x53	d2_on	0	100	No	No	No	Yes	8	0
311	3x56	I2x52	d2_on	0	100	No	No	No	No	6	0
312	4x56	5x461	d2_on	0	100	No	No	No	No	8	8
313	4x59	4x63	d2_on	0	100	No	No	No	No	6	6
314	4x60	5x39	d2_on	0	100	No	No	Yes	Yes	8	8
315	E2.A177	E2.N175	d2_on	0	100	No	No	No	Yes	4	7
316	E2.N175	E2x52	d2_on	0	100	No	Yes	No	No	7	7
317	E2x51	Lig	d2_on	0	100	Yes	No	Yes	Yes	5	0
318	5x36	5x39	d2_on	0	100	Yes	No	Yes	Yes	7	8
319	5x43	Lig	d2_on	0	100	No	No	Yes	Yes	9	0
320	5x44	5x48	d2_on	0	100	No	No	No	No	8	7
321	5x47	5x51	d2_on	0	100	Yes	Yes	No	Yes	9	7
322	5x47	6x44	d2_on	0	100	Yes	Yes	Yes	Yes	9	9
323	5x47	6x48	d2_on	0	100	Yes	Yes	Yes	Yes	9	9
324	5x51	6x44	d2_on	0	100	No	Yes	Yes	Yes	7	9
325	5x55	6x41	d2_on	0	100	No	No	No	No	6	8
326	5x56	5x60	d2_on	0	100	No	No	No	No	5	7
327	5x58	6x40	d2_on	0	100	Yes	Yes	No	No	9	9
328	5x61	6x37	d2_on	0	100	No	Yes	No	No	9	8
329	5x62	6x34	d2_on	0	100	No	No	No	No	7	8
330	5x68	6x30	d2_on	0	100	No	No	No	No	8	9
331	5x69	6x30	d2_on	0	100	No	No	No	No	6	9
332	6x39	7x52	d2_on	0	100	No	No	No	No	8	8
333	6x40	7x53	d2_on	0	100	No	No	Yes	Yes	9	9
334	6x43	7x45	d2_on	0	100	No	No	Yes	Yes	7	9
335	6x43	7x48	d2_on	0	100	No	No	No	No	7	7
336	6x48	7x45	d2_on	0	100	Yes	Yes	Yes	Yes	9	9
337	6x55	6x59	d2_on	0	100	No	No	No	No	8	6
338	7x34	E3.I403	d2_on	0	100	Yes	No	Yes	No	5	6
339	7x33	7x37	d2_on	0	100	No	No	No	No	6	5
340	7x35	7x39	d2_on	0	100	No	No	Yes	Yes	6	8
341	7x54	8x50	d2_on	0	100	No	No	Yes	Yes	8	9
342	7x55	8x54	d2_on	0	100	No	No	No	No	7	9
343	5x36	E2.N175	d2_on	0	100	Yes	No	No	Yes	7	7
344	6x35	6x39	d2_on	0	50	No	No	No	No	8	8
345	1x35	2x64	d2_on	0	50	Yes	No	No	No	5	7
346	5x65	6x30	d2_on	0	50	No	No	No	No	8	9
347	2x60	3x28	d2_on	0	0	No	No	No	No	8	7
348	2x53	7x46	d2_on	0	50	No	No	No	No	8	9
349	2x41	4x42	d2_on	0	50	No	No	No	No	7	7
350	E1x51	E1x52	d2_on	0	50	No	No	Yes	Yes	4	7
351	5x69	6x27	d2_on	0	50	No	No	No	No	6	5
352	6x28	6x35	d2_on	0	50	No	No	No	No	6	8
353	5x37	6x59	d2_on	0	50	No	No	No	No	4	6
354	3x51	5x57	d2_on	0	50	Yes	Yes	No	No	8	7
355	3x26	4x64	d2_on	0	50	Yes	No	No	No	6	7
356	2x57	2x58	d2_on	0	0	No	No	No	No	9	9
357	1x32	1x35	d2_on	0	0	No	No	Yes	No	0	5
358	4x60	E2.L174	d2_on	0	0	No	No	No	No	8	7
359	5x62	6x37	d2_on	0	50	No	No	No	No	7	8
360	3x22	E2.Q179	d2_on	0	0	No	No	No	No	3	1
361	5x41	6x59	d2_on	0	0	No	No	No	No	7	6
362	1x57	I1x50	d2_on	0	0	No	No	No	Yes	8	9
363	1x33	1x37	d2_on	0	0	No	No	No	No	7	6
364	3x27	3x31	d2_on	0	0	No	No	No	No	6	6
365	1x52	8x58	d2_on	0	50	No	Yes	No	No	8	8
366	6x28	6x32	d2_on	0	0	No	No	No	No	6	9
367	5x51	5x52	d2_on	0	0	No	Yes	No	No	7	4
368	3x22	3x23	d2_on	0	50	No	No	No	No	3	4
369	1x54	2x47	d2_on	0	0	No	No	No	No	7	9
370	1x56	8x53	d2_on	0	0	No	No	No	No	9	9
371	I2x50	I2x51	d2_on	0	50	No	No	No	No	9	0
372	3x44	3x48	d2_on	0	0	No	No	No	No	7	7
373	3x55	3x56	d2_on	0	0	No	No	No	No	8	6
374	6x57	6x61	d2_on	0	0	No	No	No	No	7	6
375	5x65	6x33	d2_on	0	0	No	No	No	No	8	9
376	3x54	5x61	d2_on	0	0	No	No	No	Yes	8	9
377	8x47	8x48	d2_on	0	0	No	No	No	No	9	5
378	5x64	5x67	d2_on	0	0	No	No	No	No	7	6
379	5x69	5x73	d2_on	0	0	No	No	No	No	6	0
380	E2.A177	E2.A185	d2_on	0	0	No	No	No	No	4	7
381	4x37	4x38	d2_on	0	0	No	No	No	No	8	6
382	2x61	2x65	d2_on	0	0	No	No	No	No	8	6
383	1x33	1x36	d2_on	0	0	No	No	No	No	7	7
384	1x41	1x45	d2_on	0	0	No	No	No	No	6	5
385	3x21	E2.Q179	d2_on	0	0	No	No	No	No	8	1
386	E2.D178	E2.N180	d2_on	0	0	No	No	No	No	3	3
387	5x38	5x42	d2_on	0	0	No	No	Yes	No	5	7
388	4x40	4x44	d2_on	0	0	No	No	No	No	6	3
389	5x41	5x42	d2_on	0	0	No	No	Yes	No	7	7

Orange: nodes, hubs and links specific of d2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of d2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	d2_off Avg Int. Strength	d2_on Avg Int. Strength	d2_off Num Of Links	d2_on Num Of Links	ConSurf
1	1x35	d2_off	0	50	4	3	5
2	1x60	d2_off	0	0	4	3	8
3	2x66	d2_off	0	0	4	3	5
4	3x24	d2_off	66.6667	0	4	3	6
5	3x26	d2_off	0	0	4	3	6
6	3x50	d2_off	100	0	6	3	9
7	4x39	d2_off	0	0	4	1	6
8	E2x51	d2_off	66.6667	0	4	2	5
9	5x36	d2_off	66.6667	0	5	3	7
10	5x42	d2_off	33.3333	0	4	2	7
11	E3.I403	d2_off	0	0	4	3	6
12	7x34	d2_off	66.6667	0	4	3	5
13	7x56	d2_off	33.3333	0	4	2	8
14	8x49	d2_off	0	0	4	2	7
15	1x46	Shared	66.6667	0	4	4	8
16	1x50	Shared	66.6667	100	4	4	9
17	E1x50	Shared	100	100	6	6	9
18	E1x52	Shared	33.3333	0	4	4	7
19	3x49	Shared	100	100	4	5	8
20	3x51	Shared	0	50	4	4	8
21	5x39	Shared	66.6667	100	4	4	8
22	5x47	Shared	33.3333	100	4	6	9
23	5x58	Shared	33.3333	100	5	5	9
24	6x44	Shared	100	100	5	5	9
25	6x48	Shared	100	100	6	7	9
26	6x51	Shared	100	50	5	4	8
27	6x52	Shared	66.6667	50	5	5	8
28	7x30	Shared	0	0	4	4	6
29	7x39	Shared	66.6667	100	5	5	8
30	7x42	Shared	100	100	7	5	8
31	7x45	Shared	66.6667	50	4	4	9
32	7x53	Shared	100	100	4	4	9
33	8x50	Shared	66.6667	100	5	4	9
34	Lig	Shared	100	100	14	12	0
35	1x52	d2_on	0	0	2	4	8
36	I1x50	d2_on	0	0	3	4	9
37	2x46	d2_on	0	100	2	4	9
38	2x50	d2_on	0	100	3	5	9
39	3x34	d2_on	0	50	3	4	7
40	I2x53	d2_on	0	100	0	5	0
41	4x61	d2_on	66.6667	50	3	4	8
42	E2.N175	d2_on	0	50	1	4	7
43	5x51	d2_on	0	0	1	4	7
44	5x61	d2_on	0	0	3	4	9

Orange: nodes, hubs and links specific of d2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of d2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	d2_off Recurrence	d2_on Recurrence	d2_off Hub1?	d2_on Hub1?	d2_off Hub2?	d2_on Hub2?	ConSurf1	ConSurf2
1	1x39	7x39	d2_off	11.7872	1.61133	No	No	Yes	Yes	7	8
2	7x39	7x42	d2_off	18.3676	0	Yes	Yes	Yes	Yes	8	8
3	6x48	7x42	d2_off	28.0495	0	Yes	Yes	Yes	Yes	9	8
4	3x39	6x44	d2_off	79.1275	0	No	No	Yes	Yes	9	9
5	2x50	3x39	d2_off	24.3231	1.28907	No	Yes	No	No	9	9
6	1x46	7x46	d2_off	11.3088	8.90262	Yes	Yes	No	No	8	9
7	2x57	7x42	d2_off	21.2722	5.87801	No	No	Yes	Yes	9	8
8	6x44	7x45	d2_off	62.0096	0	Yes	Yes	Yes	Yes	9	9
9	7x49	7x53	d2_off	54.0332	0	No	No	Yes	Yes	9	9
10	7x53	8x50	d2_off	58.8404	0	Yes	Yes	Yes	Yes	9	9
11	1x60	I1x50	d2_off	15.5868	5.09584	Yes	No	No	Yes	8	9
12	2x46	3x39	d2_off	72.7498	0	No	Yes	No	No	9	9
13	4x39	4x42	d2_off	12.8005	0	Yes	No	No	No	6	7
14	8x49	I1x50	d2_off	12.868	2.55799	Yes	No	No	Yes	7	9
15	8x47	8x50	d2_off	24.295	3.85377	No	No	Yes	Yes	9	9
16	8x47	8x49	d2_off	12.9018	0	No	No	Yes	No	9	7
17	2x38	4x42	d2_off	88.6237	0	No	No	No	No	7	7
18	2x38	3x49	d2_off	81.2384	0.0805667	No	No	Yes	Yes	7	8
19	2x39	3x49	d2_off	69.8396	0.0201417	No	No	Yes	Yes	8	8
20	2x39	3x50	d2_off	68.2634	0	No	No	Yes	No	8	9
21	5x461	Lig	d2_off	27.6217	7.63369	No	No	Yes	Yes	8	0
22	3x37	5x461	d2_off	27.0757	1.9336	No	No	No	No	8	8
23	3x37	4x53	d2_off	26.3158	0	No	No	No	No	8	8
24	3x38	4x53	d2_off	25.736	0	No	No	No	No	8	8
25	3x38	4x50	d2_off	25.6178	2.2458	No	No	No	No	8	9
26	2x53	2x57	d2_off	16.8984	0	No	No	No	No	8	9
27	2x53	3x35	d2_off	15.418	0	No	No	No	No	8	7
28	2x63	Lig	d2_off	43.7883	0	No	No	Yes	Yes	7	0
29	2x63	E1x50	d2_off	42.5218	1.96381	No	No	Yes	Yes	7	9
30	2x62	E1x52	d2_off	15.1365	2.17194	No	No	Yes	Yes	6	7
31	2x62	2x66	d2_off	13.2395	0.308839	No	No	Yes	No	6	5
32	5x39	E2x52	d2_off	18.3394	0	Yes	Yes	No	No	8	7
33	3x29	5x39	d2_off	15.311	0	No	No	Yes	Yes	6	8
34	3x29	E2x51	d2_off	14.2809	0	No	No	Yes	No	6	5
35	3x40	6x44	d2_off	13.6279	3.649	No	No	Yes	Yes	9	9
36	3x40	5x50	d2_off	12.6316	8.42929	No	No	No	No	9	9
37	3x41	5x50	d2_off	10.4475	0	No	No	No	No	8	9
38	3x42	4x49	d2_off	11.9561	6.72396	No	No	No	No	8	9
39	3x41	4x49	d2_off	11.5677	4.48823	No	No	No	No	8	9
40	3x41	4x52	d2_off	14.5173	2.2458	No	No	No	No	8	7
41	3x50	6x37	d2_off	59.5722	0	Yes	No	No	No	9	8
42	5x58	5x61	d2_off	43.7208	0	Yes	Yes	No	Yes	9	9
43	3x51	5x60	d2_off	11.714	5.79744	Yes	Yes	No	No	8	7
44	4x52	4x56	d2_off	10.1604	0	No	No	No	No	7	8
45	5x47	Lig	d2_off	16.814	0	Yes	Yes	Yes	Yes	9	0
46	5x47	5x48	d2_off	11.0329	3.66578	Yes	Yes	No	No	9	7
47	5x47	6x49	d2_off	11.5001	2.32636	Yes	Yes	No	No	9	7
48	6x36	8x47	d2_off	11.427	0	No	No	No	No	9	9
49	6x36	7x56	d2_off	10.076	1.50727	No	No	Yes	No	9	8
50	6x58	7x34	d2_off	18.9305	1.59791	No	No	Yes	No	5	5
51	6x58	E3.I403	d2_off	17.512	0.0234986	No	No	Yes	No	5	6
52	8x48	8x49	d2_off	18.7504	0	No	No	Yes	No	5	7
53	8x48	8x51	d2_off	12.7385	0	No	No	No	No	5	9
54	1x39	2x61	d2_off	10.2955	0.0402833	No	No	No	No	7	8
55	5x65	6x31	d2_off	15.7444	0	No	No	No	No	8	7
56	6x28	6x31	d2_off	12.6822	0	No	No	No	No	6	7
57	5x68	6x28	d2_off	11.1455	0	No	No	No	No	8	6
58	2x45	4x50	d2_off	26.1019	6.72396	No	No	No	No	9	9
59	6x48	Lig	d2_off	59.3301	0	Yes	Yes	Yes	Yes	9	0
60	6x44	6x48	Shared	99.6116	61.1568	Yes	Yes	Yes	Yes	9	9
61	2x50	7x46	Shared	13.1551	11.3868	No	Yes	No	No	9	9
62	1x50	2x50	Shared	18.1537	51.8446	Yes	Yes	No	Yes	9	9
63	7x45	7x49	Shared	57.9341	55.3493	Yes	Yes	No	No	9	9
64	8x50	I1x50	Shared	28.4379	11.1518	Yes	Yes	No	Yes	9	9
65	2x46	3x42	Shared	72.1475	30.8738	No	Yes	No	No	9	8
66	2x45	3x42	Shared	79.0037	22.186	No	No	No	No	9	8
67	2x45	4x46	Shared	100	13.3908	No	No	No	No	9	9
68	4x42	4x46	Shared	98.7504	11.1753	No	No	No	No	7	9
69	7x42	Lig	Shared	13.0087	58.2463	Yes	Yes	Yes	Yes	8	0
70	E1x50	E1x52	Shared	18.6378	11.558	Yes	Yes	Yes	Yes	9	7
71	E2x52	Lig	Shared	19.5835	23.2468	No	No	Yes	Yes	7	0
72	5x58	6x37	Shared	58.2719	73.1075	Yes	Yes	No	No	9	8
73	3x51	5x61	Shared	22.1728	25.8888	Yes	Yes	No	Yes	8	9
74	5x61	5x65	Shared	21.396	23.4248	No	Yes	No	No	9	8
75	7x34	Lig	Shared	27.329	20.0208	Yes	No	Yes	Yes	5	0
76	2x60	7x39	d2_on	5.85984	25.6739	No	No	Yes	Yes	8	8
77	2x60	7x42	d2_on	0.793695	52.4925	No	No	Yes	Yes	8	8
78	3x36	Lig	d2_on	1.99268	54.9263	No	No	Yes	Yes	8	0
79	3x36	6x48	d2_on	0	55.3224	No	No	Yes	Yes	8	9
80	6x48	7x45	d2_on	0	60.4518	Yes	Yes	Yes	Yes	9	9
81	2x50	7x49	d2_on	0	41.6261	No	Yes	No	No	9	9
82	6x52	Lig	d2_on	0.973825	85.733	Yes	Yes	Yes	Yes	8	0
83	6x48	6x52	d2_on	9.78328	61.8215	Yes	Yes	Yes	Yes	9	8
84	1x50	7x50	d2_on	8.1002	44.8186	Yes	Yes	No	No	9	9
85	1x49	7x50	d2_on	3.32677	43.788	No	No	No	No	9	9
86	1x48	1x49	d2_on	1.6662	42.7507	No	No	No	No	5	9
87	1x48	1x52	d2_on	0	41.7067	No	No	No	Yes	5	8
88	1x52	8x54	d2_on	5.12243	37.9905	No	Yes	No	No	8	9
89	7x54	8x54	d2_on	1.71686	34.9324	No	No	No	No	8	9
90	7x54	8x50	d2_on	0	32.8611	No	No	Yes	Yes	8	9
91	3x43	6x44	d2_on	1.61554	98.9996	No	No	Yes	Yes	8	9
92	2x46	3x43	d2_on	0	40.4142	No	Yes	No	No	9	8
93	5x47	6x52	d2_on	8.13397	33.4419	Yes	Yes	Yes	Yes	9	8
94	5x47	6x44	d2_on	0	33.7541	Yes	Yes	Yes	Yes	9	9
95	2x46	7x49	d2_on	0	13.4748	No	Yes	No	No	9	9
96	2x40	8x50	d2_on	3.14101	18.0872	No	No	Yes	Yes	9	9
97	2x37	2x40	d2_on	1.69434	17.0936	No	No	No	No	8	9
98	2x37	I2x53	d2_on	0	15.875	No	No	No	Yes	8	0
99	3x43	7x53	d2_on	0	100	No	No	Yes	Yes	8	9
100	3x33	Lig	d2_on	8.5843	31.0887	No	No	Yes	Yes	8	0
101	3x33	4x57	d2_on	0	24.5661	No	No	No	No	8	9
102	3x34	4x57	d2_on	1.58739	22.7164	No	Yes	No	No	7	9
103	3x34	3x35	d2_on	6.2989	13.3674	No	Yes	No	No	7	7
104	2x52	3x35	d2_on	7.84689	11.4774	No	No	No	No	7	7
105	2x60	3x28	d2_on	0	25.9827	No	No	No	No	8	7
106	3x28	E1x50	d2_on	3.38869	20.6251	No	No	Yes	Yes	7	9
107	2x61	2x65	d2_on	0	11.5076	No	No	No	No	8	6
108	3x50	7x53	d2_on	0	49.478	Yes	No	Yes	Yes	9	9
109	3x50	5x58	d2_on	0	47.1281	Yes	No	Yes	Yes	9	9
110	6x40	7x53	d2_on	0	48.3366	No	No	Yes	Yes	9	9
111	5x58	6x40	d2_on	0	47.0644	Yes	Yes	No	No	9	9
112	5x61	6x37	d2_on	0	59.626	No	Yes	No	No	9	8
113	3x51	3x55	d2_on	1.9758	14.4483	Yes	Yes	No	No	8	8
114	3x55	3x56	d2_on	0	11.5714	No	No	No	No	8	6
115	5x43	Lig	d2_on	0	10.8329	No	No	Yes	Yes	9	0
116	E2.N175	E2x52	d2_on	0	20.3297	No	Yes	No	No	7	7
117	5x58	6x41	d2_on	3.86715	14.4248	Yes	Yes	No	No	9	8
118	5x62	6x37	d2_on	0	11.5613	No	No	No	No	7	8
119	5x65	6x30	d2_on	0	18.198	No	No	No	No	8	9
120	5x69	6x30	d2_on	0	10.5677	No	No	No	No	6	9
121	6x43	7x45	d2_on	0	13.1827	No	No	Yes	Yes	7	9
122	6x43	7x52	d2_on	1.64368	10.2521	No	No	No	No	7	8
123	7x34	E3.I403	d2_on	0	16.8653	Yes	No	Yes	No	5	6
124	7x30	E3.I403	d2_on	7.89755	15.0089	Yes	Yes	Yes	No	6	6
125	6x51	6x55	d2_on	3.11849	10.289	Yes	Yes	No	No	8	8
126	3x26	E2.N175	d2_on	1.4917	11.2491	Yes	No	No	Yes	6	7
127	2x61	7x39	d2_on	0	13.3371	No	No	Yes	Yes	8	8
128	2x46	2x50	d2_on	0	20.5915	No	Yes	No	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	6.81333	5.84	0	0	2	1
2x57	7x42	Shared	3.99333	10.18	0	0	2	1
2x60	7x39	Shared	4.90333	5.515	1	0	1	2
2x60	7x42	Shared	4.62667	7.57	1	0	1	1
2x60	Lig	d2_off	3.69	0	1	0	1	0
2x63	E1x50	Shared	9.87	2.28	0	0	1	2
2x63	Lig	d2_off	3.19333	0	0	0	1	0
3x28	E1x50	Shared	3.67667	6.015	0	0	2	2
3x29	E2x51	d2_off	3.07333	0	0	0	2	1
3x29	5x39	d2_off	3.05667	0	0	0	2	2
3x32	7x42	Shared	7.28333	7.475	1	1	1	1
3x32	Lig	Shared	17.52	14.02	1	1	1	0
3x33	4x61	Shared	3.97333	3.725	0	0	1	2
3x33	Lig	Shared	3.55333	12.445	0	0	1	0
3x36	Lig	Shared	12.5767	5.075	0	0	1	0
3x37	5x461	Shared	9.59	9.59	0	0	2	1
3x40	6x44	Shared	3.9	5.025	0	1	2	2
4x61	5x39	Shared	5.27667	7.31	0	0	2	2
E2.L174	E2x51	d2_off	3.80667	0	0	0	2	1
5x39	E2x52	d2_off	4.18667	0	0	0	2	1
E2x52	Lig	Shared	4.73667	6.31	0	0	1	0
5x39	5x43	Shared	7.48667	5.945	0	0	2	1
5x44	6x52	Shared	4.4	6.61	0	0	2	1
5x461	Lig	Shared	3.26667	4.33	0	0	1	0
5x47	5x48	Shared	6.87667	6.19	1	1	1	2
5x47	6x52	Shared	28.58	27.865	1	1	1	1
5x47	Lig	d2_off	5.00667	0	1	1	1	0
6x44	6x48	Shared	8.68667	7.015	0	1	2	1
6x44	7x45	d2_off	10.07	0	0	1	2	2
6x48	6x51	d2_off	5.67667	0	1	1	1	1
6x48	6x52	Shared	3.34	7.52	1	1	1	1
6x48	7x41	Shared	12.67	5.625	1	1	1	2
6x48	7x42	d2_off	4.18	0	1	1	1	1
6x48	Lig	d2_off	17.08	0	1	1	1	0
6x51	6x52	Shared	7.86333	4.825	1	1	1	1
6x51	6x55	Shared	10.18	7.92	1	1	1	2
6x51	7x38	Shared	5.62	5.84	1	1	1	1
6x51	Lig	Shared	7.65333	14.53	1	1	1	0
6x52	Lig	Shared	8.64667	8.21	1	1	1	0
6x54	7x34	d2_off	3.74667	0	0	0	2	1
6x55	7x34	d2_off	11.6133	0	0	0	2	1
6x58	E3.I403	Shared	3.77667	10.62	0	1	2	2
6x58	7x34	Shared	3.87333	8.72	0	1	2	1
7x34	Lig	Shared	4.07667	6.71	0	1	1	0
7x38	7x42	Shared	3.33333	3.745	1	1	1	1
7x38	Lig	Shared	6.36667	6.235	1	1	1	0
7x42	Lig	Shared	6.03	8.765	1	1	1	0
7x39	7x42	d2_off	3.85667	0	1	2	2	1
5x36	E2x51	d2_off	2.83333	0	0	0	2	1
E2.E181	E2x51	Shared	2.73333	2.735	0	0	2	1
5x47	6x49	Shared	2.44	3.65	1	1	1	2
3x29	4x61	d2_on	0	5.215	0	0	2	2
3x29	E2x52	d2_on	0	3.84	0	0	2	1
3x33	4x57	d2_on	0	4.845	0	0	1	2
3x36	6x48	d2_on	0	5.22	0	0	1	1
3x40	6x48	d2_on	0	12.92	0	1	2	1
4x56	5x461	d2_on	0	6.965	4	0	2	1
E2.N175	E2x52	d2_on	0	7.08	0	0	2	1
E2x51	Lig	d2_on	0	6.935	0	0	1	0
5x36	5x39	d2_on	0	7.85	0	0	2	2
5x43	Lig	d2_on	0	6.31	0	0	1	0
5x44	5x48	d2_on	0	4.45	0	0	2	2
5x47	5x51	d2_on	0	8.04	1	1	1	2
5x47	6x44	d2_on	0	5.36	1	1	1	2
5x47	6x48	d2_on	0	4.01	1	1	1	1
5x51	6x44	d2_on	0	8.575	0	1	2	2
6x48	7x45	d2_on	0	9.605	1	1	1	2
7x34	E3.I403	d2_on	0	4.84	0	1	1	2
5x36	E2.N175	d2_on	0	4.085	0	0	2	2
2x60	3x28	d2_on	0	3.275	1	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	d2_off	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
	d2_on	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2

Network Difference
Value	d2_off	d2_on
I_min	3.03333	3.665
Number of Linked Nodes	263	254
Number of Specific Nodes	13 (4.94%)	4 (1.57%)
Number of Shared Nodes	250 (95.06%)	250 (98.43%)
Number of Links	287	274
Number of Specific Links	115 (40.07%)	102 (37.23%)
Number of Shared Links	172 (59.93%)	172 (62.77%)
Number of Hubs	34	30
Number of Specific Hubs	14 (41.18%)	10 (33.33%)
Number of Shared Hubs	20 (58.82%)	20 (66.67%)
Average % Shared Neighbours (Jaccard)	47.59
Average % Shared Neighbours (Otsuka)	57.68
Average % Shared Neighbours (Overlap Coefficient)	68.81
Average % Shared Cliques (k3-6)	55.56
Graphlets Similarity	0.530759

Paths Difference
Value	d2_off	d2_on
Number Of Nodes in MetaPath	72	66
Specific Nodes in MetaPath	40 (55.56%)	34 (51.52%)
Shared Nodes in MetaPath	250 (95.06%)	250 (95.06%)
Number Of Links MetaPath	75	69
Specific Links in MetaPath	59 (78.67%)	53 (76.81%)
Shared Links in MetaPath	172 (59.93%)	172 (59.93%)
Number of Shortest Paths	43502	65635
Length Of Smallest Path	3	3
Average Path Length	13.7554	13.8578
Length of Longest Path	34	30
Minimum Path Strength	0.79	0.6475
Average Path Strength	5.74886	6.5657
Maximum Path Strength	18.2217	18.0375
Minimum Path Correlation	0.703333	0.7
Average Path Correlation	0.908467	0.914375
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.22581	4
Average % Of Corr. Nodes	39.4011	40.5247
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	37.068	44.5064
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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