Orange: nodes, hubs and links specific of d2_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of d2_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner d2_on_gp Avg Int. Strength d2_off Avg Int. Strength d2_on_gp Num Of Links d2_off Num Of Links ConSurf
1G.S1.02 d2_on_gp500405
2G.S1.05 d2_on_gp500509
3G.S1.06 d2_on_gp500408
4G.H1.01 d2_on_gp1000709
5G.H1.04 d2_on_gp1000507
6G.S2.01 d2_on_gp500409
7G.S2.03 d2_on_gp500409
8G.S2.08 d2_on_gp1000405
9G.S3.01 d2_on_gp1000404
10G.S3.03 d2_on_gp1000607
11G.S3.04 d2_on_gp1000406
12G.S3.06 d2_on_gp1000505
13G.S3.08 d2_on_gp500409
14G.s3h2.03 d2_on_gp1000709
15G.H2.06 d2_on_gp1000709
16G.H2.07 d2_on_gp1000609
17G.H2.10 d2_on_gp500407
18G.h2s4.01 d2_on_gp1000709
19G.S4.02 d2_on_gp1000408
20G.S4.03 d2_on_gp1000507
21G.S4.04 d2_on_gp1000609
22G.S4.06 d2_on_gp1000507
23G.s4h3.01 d2_on_gp500407
24G.s4h3.04 d2_on_gp1000808
25G.s4h3.05 d2_on_gp1000409
26G.s4h3.08 d2_on_gp00408
27G.H3.01 d2_on_gp00409
28G.H3.02 d2_on_gp1000508
29G.H3.09 d2_on_gp1000709
30G.H3.12 d2_on_gp1000408
31G.H3.13 d2_on_gp1000505
32G.H3.17 d2_on_gp1000705
33G.H3.18 d2_on_gp1000709
34G.S5.02 d2_on_gp1000506
35G.S5.03 d2_on_gp1000508
36G.S5.04 d2_on_gp1000509
37G.S5.05 d2_on_gp1000909
38G.S5.06 d2_on_gp1000408
39G.S5.07 d2_on_gp1000509
40G.HG.04 d2_on_gp500509
41G.HG.07 d2_on_gp1000409
42G.HG.15 d2_on_gp1000407
43G.hgh4.01 d2_on_gp1000406
44G.hgh4.02 d2_on_gp1000807
45G.hgh4.05 d2_on_gp1000507
46G.H4.03 d2_on_gp1000504
47G.H4.10 d2_on_gp00406
48G.H4.11 d2_on_gp500407
49G.H4.15 d2_on_gp1000708
50G.h4s6.02 d2_on_gp500408
51G.h4s6.10 d2_on_gp1000403
52G.h4s6.11 d2_on_gp1000507
53G.S6.01 d2_on_gp500405
54G.S6.02 d2_on_gp1000607
55G.S6.05 d2_on_gp500404
56G.s6h5.01 d2_on_gp500409
57G.H5.03 d2_on_gp500408
58G.H5.08 d2_on_gp1000508
59G.H5.13 d2_on_gp00408
60G.H5.17 d2_on_gp1000605
61G.H5.20 d2_on_gp1000509
62G.H5.26 d2_on_gp1000505
63b.1x1 d2_on_gp00404
64b.1x19 d2_on_gp500406
65b.h2x1 d2_on_gp500405
66b.lhb1x3 d2_on_gp1000502
67b.lhb1x6 d2_on_gp500603
68b.lhb1x9 d2_on_gp1000403
69b.lhb1x11 d2_on_gp1000404
70b.b1x3 d2_on_gp1000507
71b.b1x6 d2_on_gp1000509
72b.l1x3 d2_on_gp1000709
73b.l1x6 d2_on_gp500409
74b.b2x1 d2_on_gp500408
75b.b2x3 d2_on_gp500506
76b.b2x5 d2_on_gp1000607
77b.b3x1 d2_on_gp500405
78b.b3x2 d2_on_gp1000405
79b.b3x3 d2_on_gp500508
80b.b3x4 d2_on_gp500409
81b.l3x1 d2_on_gp500409
82b.b4x2 d2_on_gp1000408
83b.b4x3 d2_on_gp1000507
84b.b4x4 d2_on_gp1000508
85b.b4x5 d2_on_gp1000507
86b.b4x6 d2_on_gp1000709
87b.l4x2 d2_on_gp1000404
88b.b5x2 d2_on_gp00507
89b.b5x3 d2_on_gp1000509
90b.b5x5 d2_on_gp500505
91b.b5x7 d2_on_gp1000407
92b.l5x1 d2_on_gp1000508
93b.l5x5 d2_on_gp1000909
94b.b6x5 d2_on_gp1000606
95b.l6x5 d2_on_gp1000404
96b.b7x1 d2_on_gp1000404
97b.b7x2 d2_on_gp500408
98b.b7x4 d2_on_gp500408
99b.l7x2 d2_on_gp1000709
100b.l7x4 d2_on_gp500409
101b.b8x3 d2_on_gp500506
102b.b8x4 d2_on_gp1000606
103b.l8x1 d2_on_gp1000505
104b.l8x8 d2_on_gp1000404
105b.b9x3 d2_on_gp500406
106b.l9x3 d2_on_gp1000809
107b.l9x6 d2_on_gp1000808
108b.l9x7 d2_on_gp1000507
109b.b10x3 d2_on_gp500408
110b.b10x5 d2_on_gp1000709
111b.l10x1 d2_on_gp1000503
112b.b11x2 d2_on_gp500607
113b.b11x4 d2_on_gp1000609
114b.b11x5 d2_on_gp1000506
115b.l11x2 d2_on_gp1000409
116b.b12x3 d2_on_gp500508
117b.b12x5 d2_on_gp1000506
118b.b12x6 d2_on_gp1000708
119b.b13x3 d2_on_gp500404
120b.b13x5 d2_on_gp00404
121b.b13x7 d2_on_gp1000607
122b.l13x3 d2_on_gp1000709
123b.l13x6 d2_on_gp1000509
124b.l13x7 d2_on_gp1000509
125b.b14x3 d2_on_gp1000505
126b.b14x5 d2_on_gp00405
127b.b15x1 d2_on_gp1000609
128b.b15x2 d2_on_gp1000406
129b.b15x3 d2_on_gp1000409
130b.l15x1 d2_on_gp1000507
131b.l15x2 d2_on_gp1000509
132b.b16x4 d2_on_gp1000506
133b.b16x5 d2_on_gp500405
134b.b16x6 d2_on_gp1000608
135b.b16x7 d2_on_gp500409
136b.b17x3 d2_on_gp500405
137b.b17x4 d2_on_gp500505
138b.b17x5 d2_on_gp500507
139b.b17x7 d2_on_gp1000508
140b.l17x3 d2_on_gp1000709
141b.l17x6 d2_on_gp500409
142b.l17x7 d2_on_gp1000407
143b.b18x3 d2_on_gp1000508
144b.b18x5 d2_on_gp1000505
145b.l18x1 d2_on_gp1000706
146b.l18x2 d2_on_gp1000407
147b.b19x2 d2_on_gp1000806
148b.b19x4 d2_on_gp1000508
149b.l19x1 d2_on_gp500409
150b.l19x2 d2_on_gp500409
151b.b20x2 d2_on_gp500506
152b.b20x4 d2_on_gp1000608
153b.b20x5 d2_on_gp500507
154b.b20x6 d2_on_gp1000706
155b.l20x1 d2_on_gp500406
156b.b21x1 d2_on_gp1000407
157b.b21x4 d2_on_gp500405
158b.b21x5 d2_on_gp500404
159b.b21x7 d2_on_gp1000605
160b.l21x5 d2_on_gp500404
161b.l21x7 d2_on_gp00405
162b.l21x9 d2_on_gp500406
163b.b22x5 d2_on_gp1000607
164b.l22x5 d2_on_gp1000609
165b.b23x1 d2_on_gp500405
166b.b23x2 d2_on_gp1000406
167b.b23x6 d2_on_gp1000707
168b.l23x1 d2_on_gp500406
169b.l23x2 d2_on_gp500408
170b.b24x4 d2_on_gp1000406
171b.b24x6 d2_on_gp500508
172b.l24x2 d2_on_gp1000506
173b.l24x3 d2_on_gp1000405
174b.b25x3 d2_on_gp00405
175b.b25x6 d2_on_gp00403
176b.l25x3 d2_on_gp1000609
177b.l25x6 d2_on_gp500508
178b.l25x7 d2_on_gp00407
179b.b26x3 d2_on_gp500406
180b.l26x5 d2_on_gp1000605
181b.l27x1 d2_on_gp1000709
182b.l27x2 d2_on_gp1000409
183b.b28x2 d2_on_gp1000404
184b.b28x3 d2_on_gp1000707
185b.b28x4 d2_on_gp1000506
186b.b28x5 d2_on_gp1000405
187b.b28x6 d2_on_gp1000609
188b.b28x7 d2_on_gp1000409
189g.h1x1 d2_on_gp00402
190g.h1x11 d2_on_gp00409
191g.h2x11 d2_on_gp1000406
192g.ctx3 d2_on_gp1000609
193g.ctx4 d2_on_gp500407
194g.ctx5 d2_on_gp500409
195g.ctx6 d2_on_gp500406
196g.ctx9 d2_on_gp00406
197g.ctx14 d2_on_gp1000509
198g.ctx15 d2_on_gp500409
199g.ctx16 d2_on_gp10001008
2001x52 d2_on_gp500418
201I1x50 d2_on_gp500439
2022x37 d2_on_gp500418
2032x38 d2_on_gp10066.6667437
2042x39 d2_on_gp500428
2052x46 d2_on_gp1000529
2062x50 d2_on_gp1000539
2072x57 d2_on_gp5033.3333539
2083x28 d2_on_gp500427
2093x34 d2_on_gp500437
2103x37 d2_on_gp1000428
2113x40 d2_on_gp5033.3333529
2123x41 d2_on_gp1000438
2133x43 d2_on_gp500428
2143x44 d2_on_gp033.3333427
215I2x53 d2_on_gp1000808
2164x34 d2_on_gp00427
2174x50 d2_on_gp5066.6667439
2184x56 d2_on_gp5033.3333438
2194x61 d2_on_gp5066.6667438
220E2.N175 d2_on_gp1000417
2215x48 d2_on_gp1000527
2225x50 d2_on_gp1000439
2235x51 d2_on_gp500417
2245x54 d2_on_gp500429
2255x68 d2_on_gp1000418
2266x30 d2_on_gp500539
2276x37 d2_on_gp00418
2286x55 d2_on_gp5033.3333538
2297x49 d2_on_gp10033.3333439
2307x52 d2_on_gp500428
2311x35 Shared500445
2321x46 Shared5066.6667648
2331x50 Shared10066.6667549
234E1x50 Shared100100669
235E1x52 Shared033.3333447
2363x49 Shared100100548
2373x50 Shared100100569
2383x51 Shared500448
2395x39 Shared10066.6667448
2405x47 Shared10033.3333749
2415x58 Shared10033.3333749
2426x44 Shared100100669
2436x48 Shared100100869
2446x51 Shared50100558
2456x52 Shared10066.6667758
2467x30 Shared00446
2477x34 Shared5066.6667445
2487x39 Shared10066.6667858
2497x42 Shared100100978
2507x45 Shared10066.6667449
2517x53 Shared100100849
2528x50 Shared100100469
253Lig Shared10010014150
2541x60 d2_off00348
2552x66 d2_off00345
2563x24 d2_off066.6667346
2573x26 d2_off00346
2584x39 d2_off00146
259E2x51 d2_off066.6667245
2605x36 d2_off066.6667357
2615x42 d2_off033.3333247
262E3.I403 d2_off500346
2637x56 d2_off500248
2648x49 d2_off00247
2658x54 d2_off500349
   
Orange: nodes, hubs and links specific of d2_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of d2_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner d2_on_gp Recurrence d2_off Recurrence d2_on_gp Hub1? d2_off Hub1? d2_on_gp Hub2? d2_off Hub2? ConSurf1 ConSurf2
1b.b4x4 b.b4x6 d2_on_gp16.21260YesNoYesNo89
2G.HN.47 b.b4x4 d2_on_gp15.70680NoNoYesNo68
3G.HN.47 b.b4x2 d2_on_gp15.20760NoNoYesNo68
4b.b4x2 b.b5x8 d2_on_gp14.49280YesNoNoNo85
5b.b5x7 b.b5x8 d2_on_gp14.17970YesNoNoNo75
6b.b5x5 b.l8x8 d2_on_gp10.20460YesNoYesNo54
7b.l2x5 b.l4x2 d2_on_gp10.7060NoNoYesNo54
8b.l26x5 g.ctx4 d2_on_gp29.67250YesNoYesNo57
9g.ctx3 g.ctx4 d2_on_gp31.47850YesNoYesNo97
10b.lhb1x11 g.ctx5 d2_on_gp10.47580YesNoYesNo49
11b.b25x7 b.lhb1x11 d2_on_gp57.88010NoNoYesNo74
12b.b25x7 b.b28x6 d2_on_gp57.0680NoNoYesNo79
13b.b28x6 b.l25x3 d2_on_gp56.3650YesNoYesNo99
14b.l25x3 b.l27x2 d2_on_gp99.76330YesNoYesNo99
15b.l25x4 b.l27x2 d2_on_gp1000NoNoYesNo59
16I1x48 b.l25x4 d2_on_gp99.88050NoNoNoNo85
17I1x48 I1x51 d2_on_gp99.76281.83869NoNoNoNo88
182x41 I1x51 d2_on_gp99.64413.28379NoNoNoNo78
192x41 4x42 d2_on_gp99.40620NoNoNoNo77
202x46 7x53 d2_on_gp31.34190YesNoYesYes99
213x50 7x53 d2_on_gp28.83330YesYesYesYes99
223x50 G.H5.23 d2_on_gp17.08130YesYesNoNo94
23G.H5.23 I2x53 d2_on_gp11.56080NoNoYesNo48
24b.l26x5 g.ctx16 d2_on_gp21.91580YesNoYesNo58
25b.b3x2 b.b4x6 d2_on_gp10.340YesNoYesNo59
26G.H2.09 G.H2.10 d2_on_gp17.73940NoNoYesNo87
27b.b2x1 b.l27x1 d2_on_gp17.48110YesNoYesNo89
28G.H2.10 b.l5x5 d2_on_gp23.13060YesNoYesNo79
29b.l3x1 b.l5x5 d2_on_gp15.79940YesNoYesNo99
303x50 G.H5.25 d2_on_gp15.80670YesYesNoNo97
31G.H5.20 G.H5.25 d2_on_gp17.32110YesNoNoNo97
32G.H5.20 G.H5.26 d2_on_gp12.58380YesNoYesNo95
33G.H5.17 G.H5.26 d2_on_gp10.48170YesNoYesNo55
34G.H3.17 G.H3.18 d2_on_gp25.74850YesNoYesNo59
35G.H3.12 G.H3.18 d2_on_gp20.03480YesNoYesNo89
36G.H3.12 G.S4.04 d2_on_gp19.84030YesNoYesNo89
37b.l23x1 b.l25x6 d2_on_gp28.09920YesNoYesNo68
38b.l25x6 b.l27x1 d2_on_gp34.13830YesNoYesNo89
39G.S4.04 G.S4.06 d2_on_gp15.55820YesNoYesNo97
40G.H3.02 G.S4.06 d2_on_gp10.51690YesNoYesNo87
41b.l22x3 g.ctx3 d2_on_gp19.1210NoNoYesNo99
42b.l22x3 b.l22x4 d2_on_gp19.04280NoNoNoNo99
43b.l18x1 b.l22x4 d2_on_gp12.82910YesNoNoNo69
44b.b20x5 b.b22x5 d2_on_gp13.00530YesNoYesNo77
45b.b20x5 b.b21x4 d2_on_gp43.32030YesNoYesNo75
46b.b21x4 g.h2x1 d2_on_gp96.90710YesNoNoNo58
47b.b21x2 g.h2x1 d2_on_gp96.69780NoNoNoNo68
48b.1x19 b.b21x2 d2_on_gp96.27860YesNoNoNo66
49g.ctx3 g.ctx6 d2_on_gp12.12810YesNoYesNo96
50b.l22x5 g.ctx6 d2_on_gp11.86510YesNoYesNo96
51b.l22x5 b.lhb1x3 d2_on_gp27.82820YesNoYesNo92
52b.h2x5 b.lhb1x3 d2_on_gp27.90240NoNoYesNo52
53b.h2x1 b.h2x5 d2_on_gp55.58130YesNoNoNo55
54b.b21x4 b.h2x1 d2_on_gp54.45250YesNoYesNo55
55b.l22x5 b.l24x2 d2_on_gp27.75890YesNoYesNo96
56b.h2x5 b.l24x2 d2_on_gp27.74130NoNoYesNo56
57b.1x19 b.b21x1 d2_on_gp18.11640YesNoYesNo67
58b.1x19 g.h1x14 d2_on_gp71.25590YesNoNoNo69
59b.l22x5 b.lhb1x6 d2_on_gp44.10730YesNoYesNo93
60b.lhb1x11 b.lhb1x9 d2_on_gp43.74960YesNoYesNo43
61b.b2x5 b.b3x2 d2_on_gp10.29610YesNoYesNo75
62b.b26x4 b.b2x5 d2_on_gp12.74950NoNoYesNo57
63b.b22x4 b.b26x4 d2_on_gp13.02840NoNoNoNo55
64b.b22x4 b.b26x5 d2_on_gp13.31870NoNoNoNo57
65b.b1x6 b.b4x6 d2_on_gp10.88420YesNoYesNo99
66b.b1x6 b.b28x5 d2_on_gp13.22840YesNoYesNo95
67b.b28x5 g.ctx16 d2_on_gp14.42320YesNoYesNo58
68b.b17x6 g.h1x14 d2_on_gp67.71970NoNoNoNo79
69b.b16x4 b.b17x6 d2_on_gp43.00560YesNoNoNo67
70b.b16x4 b.b16x6 d2_on_gp23.74550YesNoYesNo68
71b.b15x1 b.b16x6 d2_on_gp38.01990YesNoYesNo98
72b.b14x3 b.b15x1 d2_on_gp32.96240YesNoYesNo59
73b.b17x3 b.b17x6 d2_on_gp24.48470YesNoNoNo57
74b.b16x6 b.b17x3 d2_on_gp23.75930YesNoYesNo85
75b.l8x1 b.l8x8 d2_on_gp12.83950YesNoYesNo54
76b.b16x4 b.l13x3 d2_on_gp18.78810YesNoYesNo69
77b.l13x3 b.l13x7 d2_on_gp16.55660YesNoYesNo99
78b.b11x5 b.l13x7 d2_on_gp16.09390YesNoYesNo69
79b.b10x2 b.b11x5 d2_on_gp15.67140NoNoYesNo66
80b.b10x2 b.b6x2 d2_on_gp46.47720NoNoNoNo68
81b.b10x3 b.b6x2 d2_on_gp45.72030YesNoNoNo88
82b.b10x3 b.b11x2 d2_on_gp25.9130YesNoYesNo87
83b.b10x2 b.b14x3 d2_on_gp31.56240NoNoYesNo65
84b.b8x4 b.l8x10 d2_on_gp13.68430YesNoNoNo64
85b.b8x2 b.b8x4 d2_on_gp13.66840NoNoYesNo86
86b.b8x2 b.b9x3 d2_on_gp14.13420NoNoYesNo86
87b.b9x3 b.l8x10 d2_on_gp14.13410YesNoNoNo64
88b.l5x3 b.l5x5 d2_on_gp31.42810NoNoYesNo89
89b.l5x3 b.l7x3 d2_on_gp30.8680NoNoNoNo89
90b.b9x3 b.l7x5 d2_on_gp29.24780YesNoNoNo66
91b.l7x3 b.l7x5 d2_on_gp30.31470NoNoNoNo96
92b.b11x2 b.b8x3 d2_on_gp12.98410YesNoYesNo76
93b.b10x3 b.b11x4 d2_on_gp16.00380YesNoYesNo89
94b.b17x7 b.b21x1 d2_on_gp12.08740YesNoYesNo87
95b.b16x5 b.l20x1 d2_on_gp10.56710YesNoYesNo56
96b.l21x7 b.l23x1 d2_on_gp31.42150YesNoYesNo56
97b.b23x6 b.l21x7 d2_on_gp29.96240YesNoYesNo75
98b.b20x5 b.b21x7 d2_on_gp26.60980YesNoYesNo75
99b.b23x6 b.b24x6 d2_on_gp27.97290YesNoYesNo78
100b.b22x1 b.l25x6 d2_on_gp38.49370NoNoYesNo88
101b.b22x1 b.b22x2 d2_on_gp42.38260NoNoNoNo88
102b.b26x3 b.b27x3 d2_on_gp44.18280YesNoNoNo68
1032x46 2x50 d2_on_gp18.33720YesNoYesNo99
1043x37 Lig d2_on_gp32.0150YesNoYesYes80
1053x37 3x41 d2_on_gp16.44210YesNoYesNo88
1063x41 4x49 d2_on_gp19.56637.62498YesNoNoNo89
1073x42 4x49 d2_on_gp19.74047.81883NoNoNoNo89
1083x37 4x53 d2_on_gp16.41244.4763YesNoNoNo88
1093x38 4x53 d2_on_gp16.44333.36603NoNoNoNo88
1103x38 4x50 d2_on_gp16.61752.54362NoNoYesNo89
1112x45 4x50 d2_on_gp26.62242.99007NoNoYesNo99
1123x28 E1x50 d2_on_gp12.57642.81384YesNoYesYes79
113b.b27x3 b.l25x3 d2_on_gp43.67120NoNoYesNo89
114b.b8x4 b.l8x8 d2_on_gp17.85520YesNoYesNo64
115G.H3.17 b.l25x6 d2_on_gp32.28710YesNoYesNo58
116b.b22x2 b.b26x3 d2_on_gp42.32330NoNoYesNo86
117b.b21x7 b.b24x6 d2_on_gp28.4120YesNoYesNo58
118b.lhb1x6 b.lhb1x9 d2_on_gp43.47020YesNoYesNo33
1194x42 4x46 Shared99.28746.913NoNoNoNo79
1202x45 4x46 Shared99.167648.4051NoNoNoNo99
1212x45 3x42 Shared72.928750.6256NoNoNoNo98
1222x46 3x42 Shared53.292249.063YesNoNoNo98
1232x50 7x46 Shared10.582314.6743YesNoNoNo99
1247x42 Lig Shared10.925337.2496YesYesYesYes80
125E2x52 Lig Shared11.944222.4344NoNoYesYes70
1261x39 7x39 d2_off0.92683622.1759NoNoYesYes78
1272x60 7x39 d2_off0.068713916.7891NoNoYesYes88
1282x60 Lig d2_off017.8288NoNoYesYes80
1296x44 Lig d2_off0100YesYesYesYes90
1303x39 6x44 d2_off068.4368NoNoYesYes99
1312x50 3x39 d2_off0.10463127.6156YesNoNoNo99
1321x46 7x46 d2_off4.5619312.6123YesYesNoNo89
1337x39 7x42 d2_off8.3948129.372YesYesYesYes88
1346x48 7x42 d2_off024.8311YesYesYesYes98
1356x44 6x48 d2_off6.9174229.3603YesYesYesYes99
1362x57 7x42 d2_off0.28328733.7955YesNoYesYes98
1371x50 2x50 d2_off7.7024419.9084YesYesYesNo99
1381x50 2x51 d2_off0.81470210.6562YesYesNoNo98
1396x44 7x45 d2_off070.6926YesYesYesYes99
1407x45 7x49 d2_off1.6604365.8051YesYesYesNo99
1417x49 7x53 d2_off061.0997YesNoYesYes99
1427x53 8x50 d2_off065.4761YesYesYesYes99
1438x50 I1x50 d2_off2.2474924.3847YesYesYesNo99
1442x46 3x39 d2_off050.326YesNoNoNo99
1454x39 4x42 d2_off011.8839NoYesNoNo67
1468x49 I1x50 d2_off0.50055714.5509NoYesYesNo79
1478x47 8x50 d2_off1.0005227.8682NoNoYesYes99
1488x47 8x49 d2_off014.6449NoNoNoYes97
1492x38 4x42 d2_off035.1054YesNoNoNo77
1502x38 3x49 d2_off0.0074194126.6463YesNoYesYes78
1512x39 3x49 d2_off1.1995813.329YesNoYesYes88
1522x39 3x50 d2_off011.5667YesNoYesYes89
1532x53 2x57 d2_off026.7462NoNoYesNo89
1542x53 3x35 d2_off024.3729NoNoNoNo87
1552x52 3x35 d2_off1.2463812.3304NoNoNoNo77
1562x63 Lig d2_off035.7046NoNoYesYes70
1572x63 E1x50 d2_off1.2552334.6707NoNoYesYes79
158E1x50 E1x52 d2_off7.518915.25YesYesYesYes97
1592x62 E1x52 d2_off1.2537112.4655NoNoYesYes67
1602x62 2x66 d2_off0.93248510.9205NoNoNoYes65
1615x39 E2x52 d2_off021.4298YesYesNoNo87
1623x29 5x39 d2_off019.2093NoNoYesYes68
1633x29 E2x51 d2_off018.146NoNoNoYes65
1643x40 6x44 d2_off1.9632818.6454YesNoYesYes99
1653x40 5x50 d2_off0.62769917.1826YesNoYesNo99
1663x41 5x50 d2_off1.7489612.6711YesNoYesNo89
1673x41 4x52 d2_off1.6409513.7402YesNoNoNo87
1683x43 6x44 d2_off7.6948647.1891YesNoYesYes89
1693x43 6x41 d2_off045.6911YesNoNoNo88
1705x58 6x41 d2_off1.1077742.6129YesYesNoNo98
1715x58 5x61 d2_off031.9626YesYesNoNo99
1723x51 5x61 d2_off0.7818220.4958YesYesNoNo89
1733x51 5x60 d2_off0.80407910.85YesYesNoNo87
1745x61 5x65 d2_off010.7384NoNoNoNo98
1755x36 E2x51 d2_off012.2246NoYesNoYes75
1765x47 Lig d2_off010.6797YesYesYesYes90
1776x36 8x47 d2_off012.677NoNoNoNo99
1786x36 7x56 d2_off0.21035711.2554NoNoNoYes98
1797x34 Lig d2_off5.6488723.9558YesYesYesYes50
1806x58 7x34 d2_off0.54684415.5554NoNoYesYes55
1816x58 E3.I403 d2_off0.00067449214.3629NoNoNoYes56
1828x48 8x49 d2_off021.5649NoNoNoYes57
1831x35 7x39 d2_off2.7819414.5392YesYesYesYes58
1848x48 8x51 d2_off014.4217NoNoNoNo59
1858x51 8x55 d2_off010.8324NoNoNoNo95
1861x37 1x40 d2_off011.5726NoNoNoNo64
1871x40 2x61 d2_off015.4086NoNoNoNo48
1881x39 2x61 d2_off0.0010117419.2328NoNoNoNo78

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
2x532x57d2_off3.0400022
2x563x32Shared6.813335.840221
2x577x42Shared3.9933310.180221
2x607x39Shared4.903335.5151212
2x607x42Shared4.626677.571211
2x60Ligd2_off3.6901210
2x63E1x50Shared9.872.280012
2x63Ligd2_off3.1933300010
3x28E1x50Shared3.676676.0150022
3x29E2x51d2_off3.0733300021
3x295x39d2_off3.0566700022
3x327x42Shared7.283337.4751211
3x32LigShared17.5213.911210
3x334x61Shared3.973333.7250012
3x33LigShared3.5533312.3650010
3x36LigShared12.57675.050210
3x375x461Shared9.599.590211
3x396x44d2_off6.3100021
3x406x44Shared3.95.0250221
3x436x44Shared6.094.8750221
4x615x39Shared5.276677.310022
E2.L174E2x51d2_off3.8066700021
5x39E2x52d2_off4.1866700021
E2x52LigShared4.736676.30010
5x395x43Shared7.486675.9450021
5x406x55Shared10.14678.30021
5x446x52Shared4.46.610221
5x461LigShared3.266674.3050210
5x475x48Shared6.876676.191212
5x476x52Shared28.5827.8651211
5x47Ligd2_off5.0066701210
6x446x48Shared8.686677.0151211
6x447x45d2_off10.0701212
6x44Ligd2_off3.0266701210
6x486x51Shared5.676672.5051211
6x486x52Shared3.347.521211
6x487x41Shared12.675.6251212
6x487x42d2_off4.1801211
6x48Ligd2_off17.0801210
6x516x52Shared7.863334.8251211
6x516x55Shared10.187.921211
6x517x38Shared5.625.841211
6x51LigShared7.6533314.421210
6x52LigShared8.646678.161210
6x547x34d2_off3.7466700021
6x557x34Shared11.61333.2650211
6x58E3.I403Shared3.7766710.620222
6x587x34Shared3.873338.720221
7x34LigShared4.076676.6850210
7x387x42Shared3.333333.7451211
7x38LigShared6.366676.1751210
7x42LigShared6.038.681210
3x374x53Shared3.733333.20212
7x397x42Shared3.856672.8951221
5x36E2x51d2_off2.8333300021
E2.E181E2x51Shared2.733332.7350021
5x476x49Shared2.443.651212
2x537x42d2_on_gp02.520021
2x567x42d2_on_gp02.5250221
2x577x39d2_on_gp02.910222
2x603x28d2_on_gp03.2751212
3x283x29d2_on_gp03.2750022
3x294x61d2_on_gp05.2150022
3x29E2x52d2_on_gp03.840021
3x334x57d2_on_gp04.8450012
3x366x48d2_on_gp05.220211
3x367x42d2_on_gp02.690211
3x373x41d2_on_gp02.950212
3x37Ligd2_on_gp03.2850210
3x405x47d2_on_gp02.510221
3x406x48d2_on_gp012.920221
3x406x52d2_on_gp02.510221
4x565x43d2_on_gp03.14021
4x565x461d2_on_gp06.9654021
E2.N175E2x52d2_on_gp07.080021
E2x51Ligd2_on_gp06.8750010
5x365x39d2_on_gp07.850022
5x43Ligd2_on_gp06.260010
5x445x48d2_on_gp04.450222
5x475x51d2_on_gp08.041212
5x476x44d2_on_gp05.361211
5x476x48d2_on_gp04.011211
5x486x52d2_on_gp03.090221
5x516x44d2_on_gp08.5750221
6x487x45d2_on_gp09.6051212
6x556x59d2_on_gp03.9750212
6x55Ligd2_on_gp03.310210
7x34E3.I403d2_on_gp04.840212
5x36E2.N175d2_on_gp04.0850022
5x546x44d2_on_gp03.2450221

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
d2_on_gp 7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
8IRS-D2-Rotigotine-Gi1/β1/γ2
d2_off 6CM4-D2-Risperidone
6LUQ-D2-Haloperidol
7DFP-D2-Spiperone
Network Difference
Value d2_on_gp d2_off
Imin 2.385 3.02333
Number of Linked Nodes 855 263
Number of Specific Nodes 604 (70.64%) 12  (4.56%)
Number of Shared Nodes 251 (29.36%) 251  (95.44%)
Number of Links 1206 286
Number of Specific Links 1029 (85.32%) 109  (38.11%)
Number of Shared Links 177 (14.68%) 177  (61.89%)
Number of Hubs 253 35
Number of Specific Hubs 230 (90.91%) 12  (34.29%)
Number of Shared Hubs 23 (9.09%) 23  (65.71%)
Average % Shared Neighbours (Jaccard) 14.00
Average % Shared Neighbours (Otsuka) 17.21
Average % Shared Neighbours (Overlap Coefficient) 20.92
Average % Shared Cliques (k3-6) 50.75
Graphlets Similarity 0.663505
Paths Difference
Value d2_on_gp d2_off
Number Of Nodes in MetaPath 124 68
Specific Nodes in MetaPath 110 (88.71%) 54  (79.41%)
Shared Nodes in MetaPath 251 (29.36%) 251  (29.36%)
Number Of Links MetaPath 125 70
Specific Links in MetaPath 118 (94.40%) 63  (90.00%)
Shared Links in MetaPath 177 (14.68%) 177  (14.68%)
Number of Shortest Paths 2382909 42176
Length Of Smallest Path 3 3
Average Path Length 28.1018 11.3797
Length of Longest Path 56 24
Minimum Path Strength 0.6475 0.79
Average Path Strength 5.71846 5.1597
Maximum Path Strength 24.5425 18.2217
Minimum Path Correlation 0.7 0.703333
Average Path Correlation 0.983627 0.9091
Maximum Path Correlation 1 0.99
Minimum % Of Corr. Nodes 2.17391 5
Average % Of Corr. Nodes 43.4621 44.1614
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 57.3081 39.6197
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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