psnGPCR

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Orange: nodes, hubs and links specific of endothelin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of endothelin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	endothelin_off Int. Strength	endothelin_on Int. Strength	endothelin_off Hub1?	endothelin_on Hub1?	endothelin_off Hub2?	endothelin_on Hub2?	ConSurf1	ConSurf2
1	7x24	NT	endothelin_off	100	0	No	No	No	Yes	8	7
2	1x23	1x24	endothelin_off	100	0	No	No	No	No	4	4
3	1x24	7x27	endothelin_off	100	0	No	No	No	No	4	3
4	1x27	7x32	endothelin_off	100	0	No	No	No	No	5	1
5	1x28	7x35	endothelin_off	100	0	No	No	Yes	Yes	3	3
6	1x29	1x32	endothelin_off	100	0	No	No	Yes	No	3	6
7	1x31	1x34	endothelin_off	100	0	Yes	Yes	No	No	4	5
8	1x31	1x35	endothelin_off	100	0	Yes	Yes	Yes	No	4	5
9	1x32	E1	endothelin_off	100	0	Yes	No	No	No	6	4
10	1x35	2x64	endothelin_off	100	0	Yes	No	No	No	5	4
11	1x35	7x39	endothelin_off	100	0	Yes	No	No	No	5	5
12	1x38	7x39	endothelin_off	100	0	No	No	No	No	5	5
13	1x42	7x47	endothelin_off	100	0	No	No	No	No	8	8
14	1x49	7x50	endothelin_off	100	0	No	No	No	No	8	9
15	1x53	2x43	endothelin_off	100	0	Yes	Yes	No	No	9	8
16	1x53	7x50	endothelin_off	100	0	Yes	Yes	No	No	9	9
17	1x53	7x53	endothelin_off	100	0	Yes	Yes	No	No	9	9
18	1x56	8x54	endothelin_off	100	0	No	No	Yes	No	7	7
19	8x49	I1x50	endothelin_off	100	0	No	No	Yes	No	6	7
20	2x39	3x50	endothelin_off	100	0	No	No	Yes	No	8	9
21	2x40	3x50	endothelin_off	100	0	Yes	No	Yes	No	8	9
22	2x40	8x50	endothelin_off	100	0	Yes	No	Yes	Yes	8	9
23	2x45	4x50	endothelin_off	100	0	No	No	No	No	9	9
24	2x46	3x39	endothelin_off	100	0	Yes	Yes	No	No	9	9
25	2x48	4x50	endothelin_off	100	0	No	No	No	No	6	9
26	2x53	3x32	endothelin_off	100	0	Yes	No	No	No	8	6
27	2x53	7x46	endothelin_off	100	0	Yes	No	No	No	8	9
28	2x53	Lig	endothelin_off	100	0	Yes	No	Yes	Yes	8	0
29	2x54	7x46	endothelin_off	100	0	No	No	No	No	6	9
30	2x57	2x58	endothelin_off	100	0	Yes	No	No	No	7	9
31	2x59	E1x52	endothelin_off	100	0	No	No	Yes	Yes	6	7
32	2x62	2x66	endothelin_off	100	0	No	No	No	No	4	5
33	2x62	E1x52	endothelin_off	100	0	No	No	Yes	Yes	4	7
34	E1x49	E2	endothelin_off	100	0	No	No	Yes	Yes	5	3
35	E1x51	E1x52	endothelin_off	100	0	No	No	Yes	Yes	2	7
36	3x26	E2	endothelin_off	100	0	No	No	Yes	Yes	7	3
37	3x29	Lig	endothelin_off	100	0	No	No	Yes	Yes	5	0
38	3x30	4x57	endothelin_off	100	0	Yes	No	No	No	6	7
39	3x32	3x33	endothelin_off	100	0	No	No	Yes	No	6	4
40	3x33	5x43	endothelin_off	100	0	Yes	No	No	No	4	6
41	3x36	5x461	endothelin_off	100	0	No	No	No	No	7	6
42	3x36	Lig	endothelin_off	100	0	No	No	Yes	Yes	7	0
43	3x40	6x44	endothelin_off	100	0	No	No	Yes	No	8	9
44	3x41	4x53	endothelin_off	100	0	No	No	No	No	6	8
45	3x46	6x37	endothelin_off	100	0	No	No	No	No	9	8
46	3x48	3x52	endothelin_off	100	0	No	No	No	No	6	5
47	3x49	4x45	endothelin_off	100	0	No	Yes	No	No	8	6
48	3x50	6x33	endothelin_off	100	0	Yes	No	No	No	9	8
49	3x50	6x37	endothelin_off	100	0	Yes	No	No	No	9	8
50	3x52	4x41	endothelin_off	100	0	No	No	Yes	No	5	5
51	6x26	I2x50	endothelin_off	100	0	Yes	No	No	No	4	8
52	5x64	I2x54	endothelin_off	100	0	Yes	No	Yes	No	5	4
53	4x41	4x44	endothelin_off	100	0	Yes	No	No	No	5	3
54	4x56	5x42	endothelin_off	100	0	No	No	Yes	No	5	4
55	4x60	5x35	endothelin_off	100	0	No	No	Yes	No	8	3
56	4x61	4x65	endothelin_off	100	0	Yes	Yes	Yes	No	5	5
57	4x61	5x35	endothelin_off	100	0	Yes	Yes	Yes	No	5	3
58	4x61	5x39	endothelin_off	100	0	Yes	Yes	No	Yes	5	7
59	4x63	5x32	endothelin_off	100	0	No	No	No	No	5	4
60	4x64	E2	endothelin_off	100	0	No	Yes	Yes	Yes	5	3
61	4x65	Lig	endothelin_off	100	0	Yes	No	Yes	Yes	5	0
62	E2	E2x50	endothelin_off	100	0	Yes	Yes	No	No	3	9
63	5x33	E2	endothelin_off	100	0	No	No	Yes	Yes	1	3
64	5x29	E2	endothelin_off	100	0	No	No	Yes	Yes	3	3
65	5x35	5x42	endothelin_off	100	0	Yes	No	Yes	No	3	4
66	5x41	6x59	endothelin_off	100	0	No	No	No	No	5	5
67	5x42	5x461	endothelin_off	100	0	Yes	No	No	No	4	6
68	5x43	Lig	endothelin_off	100	0	No	No	Yes	Yes	6	0
69	5x44	5x48	endothelin_off	100	0	Yes	No	No	No	6	5
70	5x44	6x56	endothelin_off	100	0	Yes	No	No	No	6	6
71	5x46	5x461	endothelin_off	100	0	Yes	Yes	No	No	5	6
72	5x47	5x51	endothelin_off	100	0	Yes	Yes	No	No	8	7
73	5x54	6x41	endothelin_off	100	0	No	No	No	No	8	8
74	5x56	5x60	endothelin_off	100	0	No	No	No	No	4	3
75	5x58	5x62	endothelin_off	100	0	Yes	Yes	No	No	9	5
76	5x64	5x68	endothelin_off	100	0	Yes	No	No	No	5	5
77	5x68	6x30	endothelin_off	100	0	No	No	No	No	5	7
78	6x24	6x26	endothelin_off	100	0	No	No	Yes	No	2	4
79	6x24	6x27	endothelin_off	100	0	No	No	No	No	2	4
80	6x32	8x47	endothelin_off	100	0	No	No	No	No	7	8
81	6x32	8x48	endothelin_off	100	0	No	No	No	No	7	5
82	6x32	8x49	endothelin_off	100	0	No	No	No	No	7	6
83	6x35	7x56	endothelin_off	100	0	No	No	No	No	5	7
84	6x36	8x47	endothelin_off	100	0	No	No	No	No	8	8
85	6x39	7x56	endothelin_off	100	0	No	No	No	No	5	7
86	6x40	7x49	endothelin_off	100	0	No	No	Yes	No	8	9
87	6x48	Lig	endothelin_off	100	0	Yes	Yes	Yes	Yes	8	0
88	6x50	7x40	endothelin_off	100	0	No	No	No	No	9	7
89	6x51	Lig	endothelin_off	100	0	No	No	Yes	Yes	6	0
90	6x52	Lig	endothelin_off	100	0	Yes	Yes	Yes	Yes	8	0
91	6x53	6x57	endothelin_off	100	0	No	No	No	No	6	5
92	6x62	7x27	endothelin_off	100	0	Yes	No	No	No	2	3
93	7x25	E3	endothelin_off	100	0	No	No	Yes	Yes	4	1
94	7x31	7x35	endothelin_off	100	0	No	No	Yes	Yes	3	3
95	7x53	8x50	endothelin_off	100	0	No	No	Yes	Yes	9	9
96	7x54	8x51	endothelin_off	100	0	Yes	Yes	No	No	7	8
97	7x54	8x54	endothelin_off	100	0	Yes	Yes	Yes	No	7	7
98	7x54	8x55	endothelin_off	100	0	Yes	Yes	No	No	7	4
99	8x47	8x50	endothelin_off	100	0	No	No	Yes	Yes	8	9
100	8x51	8x55	endothelin_off	100	0	No	No	No	No	8	4
101	1x52	8x58	endothelin_off	100	0	No	No	No	No	6	6
102	2x63	Lig	endothelin_off	100	0	No	No	Yes	Yes	5	0
103	E1x50	E2	endothelin_off	100	0	Yes	Yes	Yes	Yes	9	3
104	6x51	6x55	endothelin_off	100	0	No	No	No	Yes	6	6
105	6x62	7x23	endothelin_off	100	0	Yes	No	No	Yes	2	5
106	I1x52	I2x54	endothelin_off	100	0	No	No	Yes	No	8	4
107	5x68	I2x50	endothelin_off	100	0	No	No	No	No	5	8
108	2x53	2x57	endothelin_off	66.6667	0	Yes	No	Yes	No	8	7
109	6x28	8x48	endothelin_off	66.6667	0	No	No	No	No	4	5
110	6x29	6x33	endothelin_off	66.6667	0	No	No	No	No	5	8
111	6x31	6x35	endothelin_off	33.3333	0	No	No	No	No	5	5
112	3x24	3x27	endothelin_off	33.3333	0	No	No	No	No	6	5
113	1x22	1x23	endothelin_off	33.3333	0	No	No	No	No	4	4
114	6x49	6x50	endothelin_off	0	0	No	No	No	No	5	9
115	2x56	3x31	endothelin_off	33.3333	0	No	Yes	No	No	6	5
116	7x23	7x24	endothelin_off	33.3333	0	No	Yes	No	No	5	8
117	3x43	6x44	endothelin_off	66.6667	0	No	No	Yes	No	8	9
118	5x34	5x38	endothelin_off	66.6667	0	No	No	No	No	1	4
119	6x58	6x62	endothelin_off	33.3333	0	No	No	Yes	No	4	2
120	7x45	7x49	endothelin_off	33.3333	0	Yes	No	Yes	No	9	9
121	6x62	7x26	endothelin_off	33.3333	0	Yes	No	No	No	2	2
122	1x27	7x28	endothelin_off	33.3333	0	No	No	No	No	5	3
123	3x47	5x57	endothelin_off	33.3333	0	No	No	Yes	No	9	7
124	3x45	4x45	endothelin_off	33.3333	0	No	No	No	No	7	6
125	7x29	7x30	endothelin_off	33.3333	0	No	No	No	No	3	3
126	2x60	2x64	endothelin_off	33.3333	0	No	No	No	No	7	4
127	2x39	3x49	endothelin_off	33.3333	0	No	No	No	Yes	8	8
128	3x22	E2	endothelin_off	33.3333	0	No	No	Yes	Yes	3	3
129	3x55	I2x50	endothelin_off	33.3333	0	No	No	No	No	7	8
130	1x39	2x57	endothelin_off	33.3333	0	No	Yes	Yes	No	7	7
131	5x53	5x57	endothelin_off	0	0	No	No	Yes	No	7	7
132	1x51	2x51	endothelin_off	33.3333	0	No	No	No	No	4	7
133	5x31	5x32	endothelin_off	33.3333	0	No	No	No	No	3	4
134	1x42	7x43	endothelin_off	0	0	No	No	No	No	8	6
135	1x58	I1x51	endothelin_off	0	0	No	No	No	No	2	7
136	3x56	5x64	endothelin_off	33.3333	0	No	No	Yes	No	7	5
137	1x26	1x30	endothelin_off	33.3333	0	No	No	No	No	5	5
138	6x27	I3	endothelin_off	33.3333	0	No	No	No	No	4	4
139	6x57	7x30	endothelin_off	33.3333	0	No	No	No	No	5	3
140	5x65	6x34	endothelin_off	0	0	No	No	No	No	8	7
141	7x42	Lig	endothelin_off	33.3333	0	No	No	Yes	Yes	7	0
142	6x43	7x49	endothelin_off	0	0	No	No	Yes	No	6	9
143	2x41	4x46	endothelin_off	0	0	No	No	No	No	6	7
144	1x54	1x58	endothelin_off	33.3333	0	No	No	No	No	7	2
145	7x51	7x55	endothelin_off	0	0	No	No	No	No	7	6
146	3x53	I2x52	endothelin_off	33.3333	0	No	No	No	No	8	5
147	6x39	7x52	endothelin_off	0	0	No	No	No	No	5	7
148	3x34	4x57	endothelin_off	0	0	No	No	No	No	6	7
149	8x50	8x54	endothelin_off	0	0	Yes	Yes	Yes	No	9	7
150	5x58	6x34	endothelin_off	0	0	Yes	Yes	No	No	9	7
151	1x36	1x40	endothelin_off	0	0	Yes	No	No	No	6	4
152	5x36	E2x52	endothelin_off	0	0	No	No	No	No	4	5
153	7x54	7x55	endothelin_off	0	0	Yes	Yes	No	No	7	6
154	1x44	1x48	endothelin_off	0	0	No	No	No	No	5	5
155	1x47	2x55	endothelin_off	0	0	No	No	No	No	7	5
156	1x36	2x64	endothelin_off	33.3333	0	Yes	No	No	No	6	4
157	1x32	2x65	endothelin_off	33.3333	0	Yes	No	No	No	6	4
158	3x21	E1x50	endothelin_off	0	0	No	No	Yes	Yes	8	9
159	1x22	1x25	endothelin_off	0	0	No	No	No	No	4	4
160	1x25	1x26	endothelin_off	33.3333	0	No	No	No	No	4	5
161	I2x54	I2x55	endothelin_off	0	0	Yes	No	No	No	4	3
162	3x53	I2x51	endothelin_off	0	0	No	No	No	No	8	5
163	3x21	3x23	endothelin_off	0	0	No	No	No	No	8	1
164	8x55	8x59	endothelin_off	0	0	No	No	No	No	4	5
165	4x47	4x51	endothelin_off	0	0	No	No	No	No	3	4
166	4x44	4x48	endothelin_off	0	0	No	No	No	No	3	3
167	4x48	4x52	endothelin_off	0	0	No	No	No	No	3	4
168	5x58	5x59	endothelin_off	0	0	Yes	Yes	No	No	9	4
169	4x41	I2x53	endothelin_off	0	0	Yes	No	No	No	5	6
170	I2x55	I2x56	endothelin_off	0	0	No	No	No	No	3	3
171	4x38	4x43	endothelin_off	0	0	No	No	No	No	6	3
172	5x62	5x63	endothelin_off	0	0	No	No	No	No	5	4
173	5x59	5x63	endothelin_off	0	0	No	No	No	No	4	4
174	4x40	4x43	endothelin_off	0	0	No	No	No	No	3	3
175	1x36	1x37	endothelin_off	0	0	Yes	No	No	No	6	6
176	6x25	6x26	endothelin_off	0	0	No	No	Yes	No	3	4
177	5x64	5x67	endothelin_off	0	0	Yes	No	No	No	5	4
178	1x55	CT	endothelin_off	0	0	No	No	No	No	3	0
179	1x27	7x31	Shared	100	0	No	No	No	No	5	3
180	1x31	7x32	Shared	100	100	Yes	Yes	No	No	4	1
181	1x31	7x35	Shared	100	50	Yes	Yes	Yes	Yes	4	3
182	1x35	7x35	Shared	100	100	Yes	No	Yes	Yes	5	3
183	1x39	2x61	Shared	100	100	No	Yes	No	No	7	7
184	1x42	7x42	Shared	100	100	No	No	No	No	8	7
185	1x43	1x47	Shared	100	100	No	No	No	No	7	7
186	1x43	2x57	Shared	100	100	No	No	Yes	No	7	7
187	1x50	2x47	Shared	100	50	Yes	Yes	No	No	9	9
188	1x50	2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
189	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
190	1x52	8x54	Shared	100	25	No	No	Yes	No	6	7
191	1x53	2x47	Shared	100	50	Yes	Yes	No	No	9	9
192	1x53	8x50	Shared	100	100	Yes	Yes	Yes	Yes	9	9
193	1x54	2x48	Shared	100	0	No	No	No	No	7	6
194	1x55	1x59	Shared	100	50	No	No	No	No	3	4
195	1x56	8x53	Shared	100	25	No	No	No	No	7	4
196	1x57	2x44	Shared	100	100	No	No	No	No	7	7
197	1x60	I1x50	Shared	100	100	No	No	Yes	No	6	7
198	I1x48	I1x51	Shared	100	100	No	No	No	No	6	7
199	2x40	I1x50	Shared	100	50	Yes	No	Yes	No	8	7
200	8x50	I1x50	Shared	100	50	Yes	Yes	Yes	No	9	7
201	2x38	2x39	Shared	100	50	No	No	No	No	7	8
202	2x45	4x46	Shared	100	100	No	No	No	No	9	7
203	2x46	2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
204	2x46	3x42	Shared	100	100	Yes	Yes	No	No	9	8
205	2x46	7x49	Shared	100	100	Yes	Yes	Yes	No	9	9
206	2x50	3x39	Shared	100	100	No	Yes	No	No	9	9
207	2x53	2x56	Shared	100	100	Yes	No	No	Yes	8	6
208	2x53	3x35	Shared	100	100	Yes	No	No	No	8	8
209	2x551	3x31	Shared	100	100	No	No	No	No	5	5
210	2x59	3x28	Shared	100	100	No	No	No	No	6	5
211	2x60	Lig	Shared	100	100	No	No	Yes	Yes	7	0
212	2x62	E1x51	Shared	100	100	No	No	No	No	4	2
213	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	5	9
214	E1x50	E1x51	Shared	100	100	Yes	Yes	No	No	9	2
215	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	9	7
216	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	9
217	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	9	9
218	3x24	E1x52	Shared	100	100	No	No	Yes	Yes	6	7
219	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
220	3x29	4x61	Shared	100	100	No	No	Yes	Yes	5	5
221	3x29	4x65	Shared	100	100	No	No	Yes	No	5	5
222	3x30	4x54	Shared	100	100	Yes	No	No	No	6	3
223	3x32	Lig	Shared	100	100	No	No	Yes	Yes	6	0
224	3x33	4x61	Shared	100	100	Yes	No	Yes	Yes	4	5
225	3x33	Lig	Shared	100	100	Yes	No	Yes	Yes	4	0
226	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	8
227	3x37	4x53	Shared	100	100	No	No	No	No	6	8
228	3x38	4x50	Shared	100	100	No	No	No	No	7	9
229	3x38	4x53	Shared	100	100	No	No	No	No	7	8
230	3x40	5x50	Shared	100	100	No	No	No	No	8	9
231	3x41	4x49	Shared	100	100	No	No	No	No	6	7
232	3x42	4x49	Shared	100	100	No	No	No	No	8	7
233	3x44	5x53	Shared	100	100	No	No	No	No	8	7
234	3x47	5x54	Shared	100	100	No	No	No	No	9	8
235	3x48	5x57	Shared	100	50	No	No	Yes	No	6	7
236	3x49	3x52	Shared	100	100	No	Yes	No	No	8	5
237	3x51	5x57	Shared	100	50	No	Yes	Yes	No	8	7
238	3x51	5x60	Shared	100	100	No	Yes	No	No	8	3
239	3x54	5x61	Shared	100	100	No	No	No	Yes	9	8
240	4x38	4x39	Shared	100	50	No	No	No	No	6	1
241	4x41	4x45	Shared	100	50	Yes	No	No	No	5	6
242	4x56	5x46	Shared	100	50	No	No	Yes	Yes	5	5
243	4x65	E2x52	Shared	100	100	Yes	No	No	No	5	5
244	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
245	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	4
246	5x32	E2	Shared	100	50	No	No	Yes	Yes	4	3
247	5x35	5x39	Shared	100	100	Yes	No	No	Yes	3	7
248	5x39	5x43	Shared	100	100	No	Yes	No	No	7	6
249	5x40	6x59	Shared	100	100	No	Yes	No	No	5	5
250	5x41	6x56	Shared	100	100	No	No	No	No	5	6
251	5x42	5x46	Shared	100	100	Yes	No	Yes	Yes	4	5
252	5x44	5x47	Shared	100	100	Yes	No	Yes	Yes	6	8
253	5x44	6x52	Shared	100	100	Yes	No	Yes	Yes	6	8
254	5x46	5x49	Shared	100	0	Yes	Yes	No	No	5	6
255	5x47	6x49	Shared	100	100	Yes	Yes	No	No	8	5
256	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	8
257	5x58	6x38	Shared	100	50	Yes	Yes	No	No	9	5
258	5x61	5x65	Shared	100	0	No	Yes	No	No	8	8
259	5x65	6x30	Shared	100	100	No	No	No	No	8	7
260	6x26	6x30	Shared	100	100	Yes	No	No	No	4	7
261	6x40	7x53	Shared	100	100	No	No	No	No	8	9
262	6x42	6x46	Shared	100	0	No	No	No	No	5	5
263	6x44	6x48	Shared	100	100	Yes	No	Yes	Yes	9	8
264	6x44	7x45	Shared	100	100	Yes	No	Yes	No	9	9
265	6x47	7x45	Shared	100	100	No	No	Yes	No	8	9
266	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	8
267	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	8
268	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	8	9
269	6x51	7x37	Shared	100	50	No	No	No	No	6	7
270	6x54	7x34	Shared	100	100	No	No	No	No	5	4
271	6x55	Lig	Shared	100	100	No	Yes	Yes	Yes	6	0
272	6x60	6x61	Shared	100	100	No	No	No	No	4	3
273	6x62	E3	Shared	100	100	Yes	No	Yes	Yes	2	1
274	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	1	1
275	7x23	E3	Shared	100	100	No	Yes	Yes	Yes	5	1
276	7x26	7x30	Shared	100	50	No	No	No	No	2	3
277	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
278	8x51	8x52	Shared	100	25	No	No	No	No	8	4
279	1x43	2x58	Shared	100	100	No	No	No	No	7	9
280	2x40	I1x52	Shared	100	100	Yes	No	No	No	8	8
281	5x56	5x57	Shared	100	50	No	No	Yes	No	4	7
282	6x55	7x34	Shared	100	100	No	Yes	No	No	6	4
283	E2	NT	Shared	100	100	Yes	Yes	No	Yes	3	7
284	1x58	1x59	Shared	100	50	No	No	No	No	2	4
285	4x59	4x60	Shared	66.6667	100	No	No	No	No	4	8
286	4x39	4x42	Shared	33.3333	100	No	No	No	No	1	7
287	4x52	4x56	Shared	33.3333	100	No	No	No	No	4	5
288	1x36	2x65	Shared	66.6667	100	Yes	No	No	No	6	4
289	1x53	1x57	Shared	33.3333	100	Yes	Yes	No	No	9	7
290	I2x52	I2x54	Shared	33.3333	0	No	No	Yes	No	5	4
291	3x30	4x62	Shared	66.6667	100	Yes	No	No	No	6	4
292	2x42	3x46	Shared	33.3333	100	No	No	No	No	7	9
293	1x50	2x51	Shared	33.3333	100	Yes	Yes	No	No	9	7
294	1x45	7x47	Shared	33.3333	50	No	No	No	No	5	8
295	5x51	6x45	Shared	33.3333	100	No	No	No	No	7	6
296	1x60	I1x49	Shared	33.3333	100	No	No	No	No	6	5
297	2x49	3x38	Shared	66.6667	50	No	No	No	No	8	7
298	3x30	3x31	Shared	66.6667	100	Yes	No	No	No	6	5
299	7x36	7x40	Shared	0	100	No	No	No	No	5	7
300	1x41	1x45	Shared	33.3333	50	No	No	No	No	4	5
301	6x54	7x33	Shared	33.3333	50	No	No	No	No	5	5
302	2x41	4x42	Shared	33.3333	25	No	No	No	No	6	7
303	2x52	3x35	Shared	33.3333	100	No	No	No	No	7	8
304	1x32	1x33	Shared	33.3333	50	Yes	No	No	No	6	3
305	6x36	7x56	Shared	33.3333	25	No	No	No	No	8	7
306	1x46	7x47	Shared	0	25	No	No	No	No	8	8
307	1x48	1x49	Shared	0	0	No	No	No	No	5	8
308	6x43	7x48	Shared	0	25	No	No	No	No	6	6
309	6x38	6x42	Shared	0	0	No	No	No	No	5	5
310	1x56	8x57	Shared	0	50	No	No	No	No	7	6
311	5x41	6x60	Shared	0	50	No	No	No	No	5	4
312	4x51	4x55	Shared	0	0	No	No	No	No	4	4
313	2x55	2x551	Shared	0	0	No	No	No	No	5	5
314	I2x53	I2x57	Shared	33.3333	50	No	No	No	Yes	6	6
315	5x33	5x37	Shared	0	25	No	No	No	No	1	4
316	I2x56	I2x57	Shared	0	100	No	No	No	Yes	3	6
317	5x44	5x45	Shared	0	50	Yes	No	No	No	6	4
318	1x30	1x31	endothelin_on	0	100	No	No	Yes	Yes	5	4
319	1x39	7x35	endothelin_on	0	100	No	Yes	Yes	Yes	7	3
320	1x39	7x39	endothelin_on	0	100	No	Yes	No	No	7	5
321	1x53	7x54	endothelin_on	0	100	Yes	Yes	Yes	Yes	9	7
322	1x56	8x50	endothelin_on	0	100	No	No	Yes	Yes	7	9
323	2x37	2x40	endothelin_on	0	100	No	No	Yes	No	0	8
324	2x38	4x42	endothelin_on	0	100	No	No	No	No	7	7
325	2x42	3x45	endothelin_on	0	100	No	No	No	No	7	7
326	2x42	3x49	endothelin_on	0	100	No	No	No	Yes	7	8
327	2x43	7x53	endothelin_on	0	100	No	No	No	No	8	9
328	2x45	3x42	endothelin_on	0	100	No	No	No	No	9	8
329	2x46	3x43	endothelin_on	0	100	Yes	Yes	No	No	9	8
330	2x50	7x46	endothelin_on	0	100	No	Yes	No	No	9	9
331	2x50	7x49	endothelin_on	0	100	No	Yes	Yes	No	9	9
332	2x54	2x57	endothelin_on	0	100	No	No	Yes	No	6	7
333	2x56	2x60	endothelin_on	0	100	No	Yes	No	No	6	7
334	2x56	3x32	endothelin_on	0	100	No	Yes	No	No	6	6
335	2x56	7x42	endothelin_on	0	100	No	Yes	No	No	6	7
336	2x57	7x42	endothelin_on	0	100	Yes	No	No	No	7	7
337	2x58	2x59	endothelin_on	0	100	No	No	No	No	9	6
338	2x60	7x38	endothelin_on	0	100	No	No	No	No	7	6
339	3x24	3x28	endothelin_on	0	100	No	No	No	No	6	5
340	3x34	4x54	endothelin_on	0	100	No	No	No	No	6	3
341	3x46	3x50	endothelin_on	0	100	No	No	Yes	No	9	9
342	3x47	5x58	endothelin_on	0	100	No	No	Yes	Yes	9	9
343	3x49	I2x57	endothelin_on	0	100	No	Yes	No	Yes	8	6
344	3x50	5x58	endothelin_on	0	100	Yes	No	Yes	Yes	9	9
345	3x51	3x55	endothelin_on	0	100	No	Yes	No	No	8	7
346	3x51	3x56	endothelin_on	0	100	No	Yes	No	No	8	7
347	3x55	5x64	endothelin_on	0	100	No	No	Yes	No	7	5
348	3x56	I2x52	endothelin_on	0	100	No	No	No	No	7	5
349	4x46	4x50	endothelin_on	0	100	No	No	No	No	7	9
350	4x50	4x54	endothelin_on	0	100	No	No	No	No	9	3
351	4x60	5x39	endothelin_on	0	100	No	No	No	Yes	8	7
352	4x61	Lig	endothelin_on	0	100	Yes	Yes	Yes	Yes	5	0
353	4x63	4x64	endothelin_on	0	100	No	No	No	Yes	5	5
354	4x64	E2x52	endothelin_on	0	100	No	Yes	No	No	5	5
355	E2	Lig	endothelin_on	0	100	Yes	Yes	Yes	Yes	3	0
356	E2x51	Lig	endothelin_on	0	100	No	No	Yes	Yes	4	0
357	E2	E2x52	endothelin_on	0	100	Yes	Yes	No	No	3	5
358	5x36	5x40	endothelin_on	0	100	No	No	No	Yes	4	5
359	5x37	6x60	endothelin_on	0	100	No	No	No	No	4	4
360	5x39	5x40	endothelin_on	0	100	No	Yes	No	Yes	7	5
361	5x42	5x43	endothelin_on	0	100	Yes	No	No	No	4	6
362	5x45	5x48	endothelin_on	0	100	No	No	No	No	4	5
363	5x49	5x50	endothelin_on	0	100	No	No	No	No	6	9
364	5x54	5x58	endothelin_on	0	100	No	No	Yes	Yes	8	9
365	5x54	6x44	endothelin_on	0	100	No	No	Yes	No	8	9
366	5x58	6x37	endothelin_on	0	100	Yes	Yes	No	No	9	8
367	5x62	6x34	endothelin_on	0	100	No	No	No	No	5	7
368	5x66	5x70	endothelin_on	0	100	No	No	No	No	5	0
369	6x28	6x32	endothelin_on	0	100	No	No	No	No	4	7
370	6x40	7x52	endothelin_on	0	100	No	No	No	No	8	7
371	6x48	6x51	endothelin_on	0	100	Yes	Yes	No	No	8	6
372	6x50	7x37	endothelin_on	0	100	No	No	No	No	9	7
373	6x51	7x38	endothelin_on	0	100	No	No	No	No	6	6
374	6x57	6x61	endothelin_on	0	100	No	No	No	No	5	3
375	6x57	E3	endothelin_on	0	100	No	No	Yes	Yes	5	1
376	6x58	E3	endothelin_on	0	100	No	No	Yes	Yes	4	1
377	6x58	Lig	endothelin_on	0	100	No	No	Yes	Yes	4	0
378	E3	Lig	endothelin_on	0	100	Yes	Yes	Yes	Yes	1	0
379	7x34	Lig	endothelin_on	0	100	No	No	Yes	Yes	4	0
380	7x54	8x50	endothelin_on	0	100	Yes	Yes	Yes	Yes	7	9
381	7x55	8x50	endothelin_on	0	100	No	No	Yes	Yes	6	9
382	Lig	Lig	endothelin_on	0	100	Yes	Yes	Yes	Yes	0	0
383	1x35	1x39	endothelin_on	0	100	Yes	No	No	Yes	5	7
384	2x551	3x28	endothelin_on	0	100	No	No	No	No	5	5
385	E1x52	E2	endothelin_on	0	100	Yes	Yes	Yes	Yes	7	3
386	3x29	4x64	endothelin_on	0	100	No	No	No	Yes	5	5
387	I2x50	I2x51	endothelin_on	0	100	No	No	No	No	8	5
388	4x61	4x64	endothelin_on	0	100	Yes	Yes	No	Yes	5	5
389	5x40	6x55	endothelin_on	0	100	No	Yes	No	Yes	5	6
390	6x29	6x32	endothelin_on	0	100	No	No	No	No	5	7
391	6x49	6x53	endothelin_on	0	100	No	No	No	No	5	6
392	8x47	8x49	endothelin_on	0	100	No	No	No	No	8	6
393	8x54	8x58	endothelin_on	0	100	Yes	No	No	No	7	6
394	5x36	Lig	endothelin_on	0	100	No	No	Yes	Yes	4	0
395	7x31	Lig	endothelin_on	0	100	No	No	Yes	Yes	3	0
396	NT	NT	endothelin_on	0	100	No	Yes	No	Yes	7	7
397	1x24	NT	endothelin_on	0	100	No	No	No	Yes	4	7
398	7x23	NT	endothelin_on	0	100	No	Yes	No	Yes	5	7
399	1x22	7x23	endothelin_on	0	100	No	No	No	Yes	4	5
400	1x24	1x25	endothelin_on	0	100	No	No	No	No	4	4
401	2x53	6x48	endothelin_on	0	100	Yes	No	Yes	Yes	8	8
402	2x64	7x35	endothelin_on	0	100	No	No	Yes	Yes	4	3
403	3x16	E1x49	endothelin_on	0	100	No	No	No	No	0	5
404	3x17	3x18	endothelin_on	0	100	No	No	No	No	0	0
405	3x36	5x46	endothelin_on	0	100	No	No	Yes	Yes	7	5
406	3x51	5x64	endothelin_on	0	100	No	Yes	Yes	No	8	5
407	5x30	5x33	endothelin_on	0	100	No	No	No	No	4	1
408	5x43	5x46	endothelin_on	0	100	No	No	Yes	Yes	6	5
409	5x46	6x52	endothelin_on	0	100	Yes	Yes	Yes	Yes	5	8
410	5x66	6x31	endothelin_on	0	100	No	No	No	No	5	5
411	6x55	6x58	endothelin_on	0	100	No	Yes	No	No	6	4
412	7x26	E3	endothelin_on	0	100	No	No	Yes	Yes	2	1
413	7x54	8x48	endothelin_on	0	100	Yes	Yes	No	No	7	5
414	3x27	3x31	endothelin_on	0	50	No	No	No	No	5	5
415	7x43	7x48	endothelin_on	0	50	No	No	No	No	6	6
416	4x57	4x61	endothelin_on	0	50	No	No	Yes	Yes	7	5
417	5x72	I3	endothelin_on	0	50	No	No	No	No	0	4
418	5x69	6x27	endothelin_on	0	50	No	No	No	No	0	4
419	2x43	7x54	endothelin_on	0	50	No	No	Yes	Yes	8	7
420	4x41	I2x56	endothelin_on	0	50	Yes	No	No	No	5	3
421	5x58	6x41	endothelin_on	0	50	Yes	Yes	No	No	9	8
422	7x27	Lig	endothelin_on	0	50	No	No	Yes	Yes	3	0
423	1x26	7x28	endothelin_on	0	50	No	No	No	No	5	3
424	3x21	E1x52	endothelin_on	0	50	No	No	Yes	Yes	8	7
425	3x51	5x61	endothelin_on	0	75	No	Yes	No	Yes	8	8
426	3x37	5x461	endothelin_on	0	50	No	No	No	No	6	6
427	5x47	6x45	endothelin_on	0	50	Yes	Yes	No	No	8	6
428	2x67	E2	endothelin_on	0	50	No	No	Yes	Yes	0	3
429	3x26	4x63	endothelin_on	0	50	No	No	No	No	7	5
430	1x26	7x27	endothelin_on	0	50	No	No	No	No	5	3
431	1x31	7x36	endothelin_on	0	50	Yes	Yes	No	No	4	5
432	4x38	4x40	endothelin_on	0	50	No	No	No	No	6	3
433	1x60	8x52	endothelin_on	0	50	No	No	No	No	6	4
434	2x66	E1x49	endothelin_on	0	50	No	No	No	No	5	5
435	6x39	6x43	endothelin_on	0	50	No	No	No	No	5	6
436	3x22	3x26	endothelin_on	0	75	No	No	No	No	3	7
437	1x39	2x65	endothelin_on	0	50	No	Yes	No	No	7	4
438	7x37	7x40	endothelin_on	0	50	No	No	No	No	7	7
439	6x36	7x52	endothelin_on	0	50	No	No	No	No	8	7
440	4x38	I1x51	endothelin_on	0	50	No	No	No	No	6	7
441	2x38	3x49	endothelin_on	0	50	No	No	No	Yes	7	8
442	7x29	7x33	endothelin_on	0	50	No	No	No	No	3	5
443	8x55	I1x49	endothelin_on	0	50	No	No	No	No	4	5
444	6x47	7x43	endothelin_on	0	50	No	No	No	No	8	6
445	E1x49	E1x51	endothelin_on	0	50	No	No	No	No	5	2
446	1x26	7x24	endothelin_on	0	50	No	No	No	No	5	8
447	5x58	5x61	endothelin_on	0	0	Yes	Yes	No	Yes	9	8
448	5x63	5x67	endothelin_on	0	50	No	No	No	No	4	4
449	6x33	6x37	endothelin_on	0	0	No	No	No	No	8	8
450	3x48	5x53	endothelin_on	0	50	No	No	No	No	6	7
451	1x54	2x44	endothelin_on	0	25	No	No	No	No	7	7
452	7x48	7x51	endothelin_on	0	50	No	No	No	No	6	7
453	1x46	2x54	endothelin_on	0	50	No	No	No	No	8	6
454	5x34	5x37	endothelin_on	0	50	No	No	No	No	1	4
455	3x20	E1x52	endothelin_on	0	50	No	No	Yes	Yes	0	7
456	I2x51	I2x52	endothelin_on	0	25	No	No	No	No	5	5
457	5x59	6x38	endothelin_on	0	50	No	No	No	No	4	5
458	3x16	3x17	endothelin_on	0	50	No	No	No	No	0	0
459	5x62	6x37	endothelin_on	0	50	No	No	No	No	5	8
460	5x70	6x26	endothelin_on	0	50	No	No	Yes	No	0	4
461	1x44	1x47	endothelin_on	0	0	No	No	No	No	5	7
462	3x23	3x27	endothelin_on	0	50	No	No	No	No	1	5
463	5x69	5x70	endothelin_on	0	0	No	No	No	No	0	0
464	1x58	2x44	endothelin_on	0	25	No	No	No	No	2	7
465	7x23	7x25	endothelin_on	0	50	No	Yes	No	No	5	4
466	1x48	1x52	endothelin_on	0	25	No	No	No	No	5	6
467	5x72	6x30	endothelin_on	0	25	No	No	No	No	0	7
468	E1	Lig	endothelin_on	0	50	No	No	Yes	Yes	4	0
469	7x56	8x47	endothelin_on	0	50	No	No	No	No	7	8
470	5x29	5x32	endothelin_on	0	50	No	No	No	No	3	4
471	5x35	5x38	endothelin_on	0	25	Yes	No	No	No	3	4
472	1x52	7x55	endothelin_on	0	25	No	No	No	No	6	6
473	5x63	5x64	endothelin_on	0	50	No	No	Yes	No	4	5
474	4x55	4x59	endothelin_on	0	0	No	No	No	No	4	4
475	5x52	5x55	endothelin_on	0	0	No	No	No	No	3	5
476	1x38	1x42	endothelin_on	0	25	No	No	No	No	5	8
477	1x28	1x31	endothelin_on	0	0	No	No	Yes	Yes	3	4
478	1x29	1x33	endothelin_on	0	0	No	No	No	No	3	3
479	1x32	1x35	endothelin_on	0	25	Yes	No	Yes	No	6	5
480	3x53	I2x57	endothelin_on	0	25	No	No	No	Yes	8	6
481	6x23	6x26	endothelin_on	0	0	No	No	Yes	No	0	4
482	1x37	1x38	endothelin_on	0	0	No	No	No	No	6	5
483	2x41	4x43	endothelin_on	0	25	No	No	No	No	6	3
484	5x48	5x52	endothelin_on	0	25	No	No	No	No	5	3
485	8x53	8x56	endothelin_on	0	0	No	No	No	No	4	5
486	1x30	1x34	endothelin_on	0	0	No	No	No	No	5	5
487	5x73	6x27	endothelin_on	0	0	No	No	No	No	0	4
488	1x51	1x55	endothelin_on	0	0	No	No	No	No	4	3
489	4x44	4x47	endothelin_on	0	0	No	No	No	No	3	3
490	4x46	4x47	endothelin_on	0	0	No	No	No	No	7	3
491	5x68	5x71	endothelin_on	0	0	No	No	No	No	5	0
492	1x27	2x64	endothelin_on	0	0	No	No	No	No	5	4
493	5x29	5x31	endothelin_on	0	0	No	No	No	No	3	3
494	6x28	6x35	endothelin_on	0	0	No	No	No	No	4	5
495	5x71	5x72	endothelin_on	0	0	No	No	No	No	0	0
496	6x23	6x25	endothelin_on	0	0	No	No	No	No	0	3
497	6x24	6x28	endothelin_on	0	0	No	No	No	No	2	4

Orange: nodes, hubs and links specific of endothelin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of endothelin_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	endothelin_off Avg Int. Strength	endothelin_on Avg Int. Strength	endothelin_off Num Of Links	endothelin_on Num Of Links	ConSurf
1	1x32	endothelin_off	0	0	4	2	6
2	1x35	endothelin_off	66.6667	0	4	3	5
3	1x36	endothelin_off	0	0	4	1	6
4	I1x50	endothelin_off	33.3333	0	4	3	7
5	2x40	endothelin_off	0	0	4	3	8
6	2x53	endothelin_off	100	0	6	3	8
7	2x57	endothelin_off	33.3333	0	4	3	7
8	3x30	endothelin_off	33.3333	0	4	3	6
9	3x33	endothelin_off	66.6667	0	4	2	4
10	3x50	endothelin_off	66.6667	0	4	2	9
11	I2x54	endothelin_off	0	0	4	1	4
12	4x41	endothelin_off	0	0	4	2	5
13	4x65	endothelin_off	66.6667	0	4	2	5
14	5x35	endothelin_off	66.6667	0	4	2	3
15	5x42	endothelin_off	0	0	4	2	4
16	5x44	endothelin_off	66.6667	0	5	3	6
17	5x57	endothelin_off	33.3333	0	5	3	7
18	5x64	endothelin_off	0	0	4	3	5
19	6x26	endothelin_off	0	0	4	3	4
20	6x44	endothelin_off	100	0	4	3	9
21	6x62	endothelin_off	33.3333	0	5	1	2
22	7x45	endothelin_off	33.3333	0	4	3	9
23	7x49	endothelin_off	0	0	4	2	9
24	8x54	endothelin_off	0	0	4	2	7
25	1x31	Shared	33.3333	0	4	5	4
26	1x50	Shared	0	50	4	4	9
27	1x53	Shared	33.3333	0	6	4	9
28	2x46	Shared	33.3333	0	4	4	9
29	E1x50	Shared	100	50	7	5	9
30	E1x52	Shared	100	100	5	5	7
31	4x61	Shared	100	50	5	5	5
32	E2	Shared	100	100	13	9	3
33	5x46	Shared	100	50	4	6	5
34	5x47	Shared	66.6667	25	4	4	8
35	5x58	Shared	0	100	4	7	9
36	6x48	Shared	100	100	6	7	8
37	6x52	Shared	33.3333	0	4	4	8
38	E3	Shared	100	100	5	8	1
39	7x35	Shared	100	50	4	4	3
40	7x54	Shared	0	0	4	4	7
41	8x50	Shared	66.6667	25	6	5	9
42	Lig	Shared	100	100	15	17	0
43	NT	endothelin_on	33.3333	50	2	5	7
44	1x39	endothelin_on	0	100	2	5	7
45	2x50	endothelin_on	33.3333	75	3	5	9
46	2x56	endothelin_on	33.3333	0	2	4	6
47	3x49	endothelin_on	0	0	3	4	8
48	3x51	endothelin_on	0	50	2	6	8
49	I2x57	endothelin_on	0	0	2	4	6
50	4x64	endothelin_on	0	0	1	4	5
51	5x39	endothelin_on	33.3333	25	3	4	7
52	5x40	endothelin_on	0	0	1	4	5
53	5x61	endothelin_on	0	0	2	4	8
54	6x55	endothelin_on	0	50	3	4	6
55	7x23	endothelin_on	33.3333	50	3	4	5

Orange: nodes, hubs and links specific of endothelin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of endothelin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	endothelin_off Recurrence	endothelin_on Recurrence	endothelin_off Hub1?	endothelin_on Hub1?	endothelin_off Hub2?	endothelin_on Hub2?	ConSurf1	ConSurf2
1	6x62	7x27	endothelin_off	11.4876	0	Yes	No	No	No	2	3
2	6x62	7x23	endothelin_off	22.3587	0	Yes	No	No	Yes	2	5
3	7x23	7x24	endothelin_off	27.1776	0	No	Yes	No	No	5	8
4	1x35	2x64	endothelin_off	20.9182	0	Yes	No	No	No	5	4
5	2x60	2x64	endothelin_off	34.6909	0	No	No	No	No	7	4
6	2x63	Lig	endothelin_off	67.475	0	No	No	Yes	Yes	5	0
7	2x63	E1x50	endothelin_off	66.418	1.76269	No	No	Yes	Yes	5	9
8	E1x50	E2	endothelin_off	46.4428	0	Yes	Yes	Yes	Yes	9	3
9	E2	NT	endothelin_off	29.7839	5.25651	Yes	Yes	No	Yes	3	7
10	7x24	NT	endothelin_off	28.4782	0	No	No	No	Yes	8	7
11	1x36	2x64	endothelin_off	13.3323	0	Yes	No	No	No	6	4
12	2x53	2x57	endothelin_off	11.7674	0	Yes	No	Yes	No	8	7
13	2x53	Lig	endothelin_off	33.5095	0	Yes	No	Yes	Yes	8	0
14	1x42	7x42	endothelin_off	10.0679	6.57722	No	No	No	No	8	7
15	7x42	Lig	endothelin_off	11.7105	0	No	No	Yes	Yes	7	0
16	2x46	7x49	endothelin_off	44.5515	1.45751	Yes	Yes	Yes	No	9	9
17	7x45	7x49	endothelin_off	100	0	Yes	No	Yes	No	9	9
18	6x48	7x45	endothelin_off	97.4506	8.61352	Yes	Yes	Yes	No	8	9
19	6x48	Lig	endothelin_off	83.3152	0	Yes	Yes	Yes	Yes	8	0
20	6x40	7x53	endothelin_off	81.1752	9.80795	No	No	No	No	8	9
21	6x40	7x49	endothelin_off	81.7555	0	No	No	Yes	No	8	9
22	8x50	8x54	endothelin_off	20.2705	0	Yes	Yes	Yes	No	9	7
23	7x53	8x50	endothelin_off	72.3405	0	No	No	Yes	Yes	9	9
24	1x54	2x48	endothelin_off	11.042	1.69955	No	No	No	No	7	6
25	2x48	4x50	endothelin_off	12.6017	0	No	No	No	No	6	9
26	3x38	4x50	endothelin_off	26.1723	8.08208	No	No	No	No	7	9
27	3x38	4x53	endothelin_off	29.074	4.74612	No	No	No	No	7	8
28	3x41	4x53	endothelin_off	31.9343	0	No	No	No	No	6	8
29	3x41	4x49	endothelin_off	33.3489	1.69955	No	No	No	No	6	7
30	3x42	4x49	endothelin_off	34.7531	3.39384	No	No	No	No	8	7
31	2x39	3x50	endothelin_off	17.0838	0	No	No	Yes	No	8	9
32	2x40	3x50	endothelin_off	23.3846	0	Yes	No	Yes	No	8	9
33	2x40	8x50	endothelin_off	59.7492	0	Yes	No	Yes	Yes	8	9
34	2x45	4x50	endothelin_off	12.7623	0	No	No	No	No	9	9
35	2x56	3x31	endothelin_off	13.4359	0	No	Yes	No	No	6	5
36	3x36	Lig	endothelin_off	33.0432	0	No	No	Yes	Yes	7	0
37	3x36	5x461	endothelin_off	43.4116	0	No	No	No	No	7	6
38	3x48	5x57	endothelin_off	25.4884	4.82505	No	No	Yes	No	6	7
39	3x48	3x52	endothelin_off	27.9807	0	No	No	No	No	6	5
40	3x52	4x41	endothelin_off	25.3226	0	No	No	Yes	No	5	5
41	4x41	4x44	endothelin_off	35.178	0	Yes	No	No	No	5	3
42	4x44	4x48	endothelin_off	36.2402	0	No	No	No	No	3	3
43	4x48	4x52	endothelin_off	37.3646	0	No	No	No	No	3	4
44	4x52	4x56	endothelin_off	38.7067	4.30413	No	No	No	No	4	5
45	4x56	5x42	endothelin_off	21.2654	0	No	No	Yes	No	5	4
46	5x42	5x461	endothelin_off	21.2187	0	Yes	No	No	No	4	6
47	4x56	5x46	endothelin_off	19.4311	7.94528	No	No	Yes	Yes	5	5
48	5x46	5x461	endothelin_off	21.1099	0	Yes	Yes	No	No	5	6
49	3x49	3x52	endothelin_off	11.5809	1.61536	No	Yes	No	No	8	5
50	2x39	3x49	endothelin_off	14.8609	0	No	No	No	Yes	8	8
51	5x68	6x30	endothelin_off	26.6957	0	No	No	No	No	5	7
52	5x64	5x68	endothelin_off	37.9761	0	Yes	No	No	No	5	5
53	5x64	I2x54	endothelin_off	41.6343	0	Yes	No	Yes	No	5	4
54	I1x52	I2x54	endothelin_off	44.6344	0	No	No	Yes	No	8	4
55	2x40	I1x52	endothelin_off	45.9143	1.36806	Yes	No	No	No	8	8
56	4x60	5x35	endothelin_off	10.7415	0	No	No	Yes	No	8	3
57	4x61	5x35	endothelin_off	11.2234	0	Yes	Yes	Yes	No	5	3
58	5x44	6x56	endothelin_off	11.3374	0	Yes	No	No	No	6	6
59	5x44	6x52	endothelin_off	16.5501	7.38753	Yes	No	Yes	Yes	6	8
60	6x52	Lig	endothelin_off	15.4982	0	Yes	Yes	Yes	Yes	8	0
61	5x47	6x52	endothelin_off	12.8711	7.38753	Yes	Yes	Yes	Yes	8	8
62	5x58	6x34	endothelin_off	12.4566	0	Yes	Yes	No	No	9	7
63	5x65	6x34	endothelin_off	13.9696	0	No	No	No	No	8	7
64	5x68	I2x50	endothelin_off	10.1611	0	No	No	No	No	5	8
65	8x47	8x50	endothelin_off	15.4464	0	No	No	Yes	Yes	8	9
66	7x54	8x54	endothelin_off	11.1301	0	Yes	Yes	Yes	No	7	7
67	2x60	Lig	Shared	35.9967	10.9761	No	No	Yes	Yes	7	0
68	1x50	2x50	Shared	11.2648	60.9208	Yes	Yes	No	Yes	9	9
69	2x46	2x50	Shared	10.156	64.4041	Yes	Yes	No	Yes	9	9
70	2x46	3x42	Shared	36.1469	68.2768	Yes	Yes	No	No	9	8
71	2x45	4x46	Shared	11.2027	72.9703	No	No	No	No	9	7
72	2x53	2x56	Shared	15.0733	16.964	Yes	No	No	Yes	8	6
73	E1x50	E1x52	Shared	11.5291	17.4112	Yes	Yes	Yes	Yes	9	7
74	5x65	6x30	Shared	18.4362	18.7845	No	No	No	No	8	7
75	3x36	6x48	Shared	11.5291	14.4173	No	No	Yes	Yes	7	8
76	6x48	6x52	Shared	15.6744	27.7716	Yes	Yes	Yes	Yes	8	8
77	1x31	7x35	endothelin_on	0.0362713	10.4394	Yes	Yes	Yes	Yes	4	3
78	7x36	7x40	endothelin_on	1.91202	10.8761	No	No	No	No	5	7
79	7x37	7x40	endothelin_on	0	12.4336	No	No	No	No	7	7
80	6x51	7x37	endothelin_on	1.69957	15.538	No	No	No	No	6	7
81	6x48	6x51	endothelin_on	0	84.1936	Yes	Yes	No	No	8	6
82	2x53	6x48	endothelin_on	0	12.9071	Yes	No	Yes	Yes	8	8
83	2x56	7x42	endothelin_on	0	25.6459	No	Yes	No	No	6	7
84	2x57	7x42	endothelin_on	0	20.4262	Yes	No	No	No	7	7
85	1x43	2x57	endothelin_on	5.05726	12.7861	No	No	Yes	No	7	7
86	6x51	7x38	endothelin_on	0	77.1639	No	No	No	No	6	6
87	2x56	2x60	endothelin_on	0	11.7653	No	Yes	No	No	6	7
88	2x64	7x35	endothelin_on	0	14.6698	No	No	Yes	Yes	4	3
89	1x27	2x64	endothelin_on	0	15.8853	No	No	No	No	5	4
90	1x27	7x31	endothelin_on	3.34732	17.1271	No	No	No	No	5	3
91	7x31	Lig	endothelin_on	0	18.3636	No	No	Yes	Yes	3	0
92	3x32	Lig	endothelin_on	1.50785	11.2023	No	No	Yes	Yes	6	0
93	2x56	3x32	endothelin_on	0	10.8813	No	Yes	No	No	6	6
94	E2	Lig	endothelin_on	0	100	Yes	Yes	Yes	Yes	3	0
95	E1x52	E2	endothelin_on	0	98.3373	Yes	Yes	Yes	Yes	7	3
96	3x24	E1x52	endothelin_on	3.37323	88.3767	No	No	Yes	Yes	6	7
97	3x24	3x28	endothelin_on	0	87.5664	No	No	No	No	6	5
98	2x551	3x28	endothelin_on	0	91.7916	No	No	No	No	5	5
99	2x551	3x31	endothelin_on	3.45614	89.8448	No	No	No	No	5	5
100	3x30	3x31	endothelin_on	8.54448	86.8456	Yes	No	No	No	6	5
101	3x30	4x54	endothelin_on	1.72548	84.7935	Yes	No	No	No	6	3
102	4x50	4x54	endothelin_on	0	82.6993	No	No	No	No	9	3
103	4x46	4x50	endothelin_on	0	76.3799	No	No	No	No	7	9
104	2x45	3x42	endothelin_on	0	71.8127	No	No	No	No	9	8
105	1x50	2x47	endothelin_on	4.21265	57.1008	Yes	Yes	No	No	9	9
106	1x53	2x47	endothelin_on	4.60646	55.8064	Yes	Yes	No	No	9	9
107	1x53	1x57	endothelin_on	3.75667	13.3386	Yes	Yes	No	No	9	7
108	1x53	7x54	endothelin_on	0	15.3223	Yes	Yes	Yes	Yes	9	7
109	1x53	8x50	endothelin_on	9.54972	28.3346	Yes	Yes	Yes	Yes	9	9
110	1x57	2x44	endothelin_on	1.88093	11.7074	No	No	No	No	7	7
111	8x50	I1x50	endothelin_on	4.74118	13.7174	Yes	Yes	Yes	No	9	7
112	6x44	6x48	endothelin_on	4.09866	79.2791	Yes	No	Yes	Yes	9	8
113	5x54	6x44	endothelin_on	0	80.8682	No	No	Yes	No	8	9
114	5x54	5x58	endothelin_on	0	78.6635	No	No	Yes	Yes	8	9
115	3x50	5x58	endothelin_on	0	31.5759	Yes	No	Yes	Yes	9	9
116	3x46	3x50	endothelin_on	0	30.4657	No	No	Yes	No	9	9
117	2x42	3x46	endothelin_on	1.41976	29.1134	No	No	No	No	7	9
118	2x42	3x49	endothelin_on	0	26.5404	No	No	No	Yes	7	8
119	2x38	3x49	endothelin_on	0	15.7169	No	No	No	Yes	7	8
120	2x38	4x42	endothelin_on	0	12.6651	No	No	No	No	7	7
121	2x43	7x54	endothelin_on	0	13.0439	No	No	Yes	Yes	8	7
122	2x43	7x53	endothelin_on	0	11.4496	No	No	No	No	8	9
123	2x54	2x57	endothelin_on	0	11.2286	No	No	Yes	No	6	7
124	4x61	Lig	endothelin_on	0	10.6919	Yes	Yes	Yes	Yes	5	0
125	3x36	5x46	endothelin_on	0	13.1544	No	No	Yes	Yes	7	5
126	5x46	5x49	endothelin_on	1.66848	12.8913	Yes	Yes	No	No	5	6
127	5x46	6x52	endothelin_on	0	13.8806	Yes	Yes	Yes	Yes	5	8
128	5x58	5x61	endothelin_on	0	44.7777	Yes	Yes	No	Yes	9	8
129	3x51	5x61	endothelin_on	0	24.6619	No	Yes	No	Yes	8	8
130	6x55	Lig	endothelin_on	6.49256	16.5588	No	Yes	Yes	Yes	6	0
131	5x40	6x55	endothelin_on	0	17.0008	No	Yes	No	Yes	5	6
132	5x39	5x40	endothelin_on	0	28.2031	No	Yes	No	Yes	7	5
133	4x60	5x39	endothelin_on	0	11.8495	No	No	No	Yes	8	7
134	5x36	Lig	endothelin_on	0	16.3641	No	No	Yes	Yes	4	0
135	5x36	5x40	endothelin_on	0	15.2276	No	No	No	Yes	4	5
136	E3	Lig	endothelin_on	0	22.4572	Yes	Yes	Yes	Yes	1	0
137	6x57	E3	endothelin_on	0	15.5748	No	No	Yes	Yes	5	1
138	6x57	6x61	endothelin_on	0	14.1489	No	No	No	No	5	3
139	6x60	6x61	endothelin_on	1.91202	12.3704	No	No	No	No	4	3
140	5x43	5x46	endothelin_on	0	18.5741	No	No	Yes	Yes	6	5
141	5x61	5x65	endothelin_on	3.17633	20.3052	No	Yes	No	No	8	8
142	6x26	6x30	endothelin_on	7.8916	12.7966	Yes	No	No	No	4	7
143	E1x50	E1x51	endothelin_on	4.9329	10.6972	Yes	Yes	No	No	9	2
144	7x38	Lig	endothelin_on	1.69957	76.1589	No	No	Yes	Yes	6	0
145	5x39	5x43	endothelin_on	4.736	20.763	No	Yes	No	No	7	6

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x24	7x27	endothelin_off	4.37667	0	0	1	2	1
1x27	7x31	Shared	3.80667	0.715	0	0	2	1
1x32	E1	endothelin_off	3.6	0	0	0	2	1
1x42	7x42	Shared	5.38333	3.9475	0	0	2	1
2x53	2x56	Shared	8.67333	6.0075	1	0	1	2
2x53	3x32	endothelin_off	5.77	0	1	0	1	1
2x53	3x35	Shared	5.11	4.2725	1	0	1	2
2x53	7x46	endothelin_off	5.11333	0	1	0	1	2
2x53	Lig	endothelin_off	11.43	0	1	0	1	0
2x60	Lig	Shared	5.92	7.835	0	1	1	0
2x63	E1x50	Shared	6.96	4.8475	0	0	1	2
E1x49	E2	endothelin_off	16.95	0	0	0	2	1
E1x50	E1x52	Shared	13.3633	9.6475	2	1	2	2
E1x50	E2x50	Shared	8.70667	12.6325	2	1	2	2
3x26	E2	endothelin_off	5.99333	0	0	0	2	1
3x29	4x61	Shared	5.76333	5.4825	1	1	1	1
3x29	4x65	Shared	15.41	4.01	1	1	1	1
3x29	Lig	endothelin_off	4.94667	0	1	1	1	0
3x32	3x33	endothelin_off	8.13667	0	1	1	1	1
3x32	Lig	Shared	20.8633	4.575	1	1	1	0
3x33	4x61	Shared	11.7	7.885	1	1	1	1
3x33	5x43	endothelin_off	4.7	0	1	1	1	1
3x33	Lig	Shared	14.27	5.6975	1	1	1	0
3x36	5x461	endothelin_off	4.20667	0	1	0	1	2
3x36	6x48	Shared	6.95	5.515	1	0	1	1
3x36	Lig	endothelin_off	4.68333	0	1	0	1	0
4x61	4x65	endothelin_off	7.77333	0	1	1	1	1
4x61	5x35	endothelin_off	8.97667	0	1	1	1	2
4x61	5x39	endothelin_off	8.55	0	1	1	1	2
4x64	E2	endothelin_off	4.38333	0	0	1	2	1
4x65	E2x52	Shared	7.71333	7.69	1	0	1	2
4x65	Lig	endothelin_off	4.31	0	1	0	1	0
E2	E2	Shared	75.5367	61.545	2	1	1	1
E2	E2x50	endothelin_off	5.45667	0	2	1	1	2
E2	E2x51	Shared	9.04	11.0625	2	1	1	1
5x32	E2	Shared	10.8767	2.425	2	1	2	1
5x33	E2	endothelin_off	6.93	0	2	0	2	1
5x29	E2	endothelin_off	4.00333	0	0	0	2	1
5x35	5x39	Shared	11.1467	4.775	1	0	2	2
5x35	5x42	endothelin_off	4.18	0	1	0	2	2
5x39	5x43	Shared	5.64	8.1075	1	0	2	1
5x42	5x46	Shared	14.03	7.03	1	2	2	2
5x42	5x461	endothelin_off	4.18	0	1	2	2	2
5x43	Lig	endothelin_off	9.39667	0	1	2	1	0
5x44	5x47	Shared	6.07	5.5025	1	2	2	2
5x44	6x52	Shared	8.29667	5.785	1	2	2	1
5x46	5x461	endothelin_off	13.0633	0	1	2	2	2
5x47	6x52	Shared	17.3467	9.1675	1	2	2	1
6x44	6x48	Shared	14.6967	5.26	1	2	2	1
6x44	7x45	Shared	6.04	3.625	1	2	2	2
6x48	6x52	Shared	6.34667	4.0675	1	2	1	1
6x48	7x41	Shared	8.64667	7.32	1	2	1	2
6x48	7x45	Shared	6.78	5.455	1	2	1	2
6x48	Lig	endothelin_off	13.2	0	1	2	1	0
6x51	7x37	Shared	3.99	3.065	1	0	1	2
6x51	Lig	endothelin_off	5.78333	0	1	0	1	0
6x52	Lig	endothelin_off	4.93667	0	1	2	1	0
6x54	7x34	Shared	4.11667	5.225	0	0	2	1
6x55	Lig	Shared	9.92333	11.4925	1	1	1	0
6x62	E3	Shared	10.9067	4.72	6	0	2	1
6x62	7x27	endothelin_off	9.76667	0	6	0	2	1
E3	E3	Shared	19.5133	11.6275	6	1	1	1
7x23	E3	Shared	9.42	3.715	6	1	2	1
7x25	E3	endothelin_off	7.88667	0	0	0	2	1
7x31	7x35	endothelin_off	7.42333	0	0	1	1	2
7x38	Lig	Shared	8.03	6.24	0	1	1	0
2x63	Lig	endothelin_off	5.05333	0	0	0	1	0
E1x50	E2	endothelin_off	4.30667	0	2	1	2	1
6x51	6x55	endothelin_off	4.05	0	1	0	1	1
6x55	7x34	Shared	9.13	4.17	1	1	1	1
6x62	7x23	endothelin_off	5.48667	0	6	0	2	2
E2	NT	Shared	6.26333	12.745	2	1	1	2
2x53	2x57	endothelin_off	3.53333	0	1	0	1	2
6x58	6x62	endothelin_off	3.18333	0	0	1	1	2
6x62	7x26	endothelin_off	3.12667	0	6	0	2	2
2x60	2x64	endothelin_off	2.74667	0	0	1	1	2
3x22	E2	endothelin_off	2.62333	0	0	0	2	1
7x42	Lig	endothelin_off	2.14	0	0	0	1	0
5x36	E2x52	endothelin_off	1.57667	0	0	1	1	2
2x56	2x60	endothelin_on	0	4.4325	0	0	2	1
2x56	3x32	endothelin_on	0	12.625	0	0	2	1
2x56	7x42	endothelin_on	0	3.6975	0	0	2	1
2x57	7x42	endothelin_on	0	6.2425	1	0	2	1
2x60	7x38	endothelin_on	0	4.2025	0	1	1	1
4x61	Lig	endothelin_on	0	6.8775	1	1	1	0
4x64	E2x52	endothelin_on	0	9.2825	0	1	2	2
E2	Lig	endothelin_on	0	28.1675	2	1	1	0
E2x51	Lig	endothelin_on	0	11.345	0	1	1	0
E2	E2x52	endothelin_on	0	3.655	2	1	1	2
5x36	5x40	endothelin_on	0	4.0175	0	1	1	2
5x39	5x40	endothelin_on	0	4.0875	1	0	2	2
5x42	5x43	endothelin_on	0	3.8025	1	2	2	1
6x48	6x51	endothelin_on	0	4.02	1	2	1	1
6x51	7x38	endothelin_on	0	3.9225	1	0	1	1
6x57	E3	endothelin_on	0	12.9175	0	1	2	1
6x58	E3	endothelin_on	0	6.8075	0	1	1	1
6x58	Lig	endothelin_on	0	13.705	0	1	1	0
E3	Lig	endothelin_on	0	15.135	6	1	1	0
7x34	Lig	endothelin_on	0	19.48	0	1	1	0
E1x52	E2	endothelin_on	0	3.625	2	1	2	1
3x29	4x64	endothelin_on	0	6.2425	1	1	1	2
4x61	4x64	endothelin_on	0	6.4525	1	1	1	2
5x40	6x55	endothelin_on	0	5.1275	0	0	2	1
5x36	Lig	endothelin_on	0	5.775	0	1	1	0
7x31	Lig	endothelin_on	0	6.99	0	1	1	0
NT	NT	endothelin_on	0	3.825	2	1	2	2
1x24	NT	endothelin_on	0	3.945	0	1	2	2
7x23	NT	endothelin_on	0	4.18	6	1	2	2
2x53	6x48	endothelin_on	0	3.375	1	0	1	1
2x64	7x35	endothelin_on	0	11.135	0	0	2	2
3x36	5x46	endothelin_on	0	6.31	1	0	1	2
5x43	5x46	endothelin_on	0	5.86	1	2	1	2
5x46	6x52	endothelin_on	0	4.355	1	2	2	1
6x55	6x58	endothelin_on	0	6.805	1	1	1	1
7x26	E3	endothelin_on	0	3.435	0	1	2	1
4x57	4x61	endothelin_on	0	3.2925	0	0	2	1
7x27	Lig	endothelin_on	0	3.15	0	1	1	0
2x67	E2	endothelin_on	0	2.92	0	0	2	1
1x26	7x27	endothelin_on	0	2.82	0	0	2	1
3x22	3x26	endothelin_on	0	2.6675	0	0	2	2
7x23	7x25	endothelin_on	0	1.745	6	1	2	2
E1	Lig	endothelin_on	0	1.65	0	0	1	0
5x29	5x32	endothelin_on	0	1.535	0	0	2	2
1x27	2x64	endothelin_on	0	0.715	0	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	endothelin_off	etb_off
	endothelin_on	etb_on eta_on

Network Difference
Value	endothelin_off	endothelin_on
I_min	3.56333	3.345
Number of Linked Nodes	280	291
Number of Specific Nodes	6 (2.14%)	17 (5.84%)
Number of Shared Nodes	274 (97.86%)	274 (94.16%)
Number of Links	317	319
Number of Specific Links	178 (56.15%)	180 (56.43%)
Number of Shared Links	139 (43.85%)	139 (43.57%)
Number of Hubs	42	31
Number of Specific Hubs	24 (57.14%)	13 (41.94%)
Number of Shared Hubs	18 (42.86%)	18 (58.06%)
Average % Shared Neighbours (Jaccard)	29.97
Average % Shared Neighbours (Otsuka)	39.77
Average % Shared Neighbours (Overlap Coefficient)	49.41
Average % Shared Cliques (k3-6)	77.03
Graphlets Similarity	0.595843

Paths Difference
Value	endothelin_off	endothelin_on
Number Of Nodes in MetaPath	74	75
Specific Nodes in MetaPath	42 (56.76%)	43 (57.33%)
Shared Nodes in MetaPath	274 (97.86%)	274 (97.86%)
Number Of Links MetaPath	76	79
Specific Links in MetaPath	66 (86.84%)	69 (87.34%)
Shared Links in MetaPath	139 (43.85%)	139 (43.85%)
Number of Shortest Paths	49849	47740
Length Of Smallest Path	3	3
Average Path Length	12.8581	15.101
Length of Longest Path	33	43
Minimum Path Strength	0.551667	0.7575
Average Path Strength	5.89283	5.58204
Maximum Path Strength	17.0317	23.8237
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.930451	0.920527
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4	2.7027
Average % Of Corr. Nodes	50.905	44.356
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	43.7098	34.9231
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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