psnGPCR

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Orange: nodes, hubs and links specific of ghrelin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ghrelin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ghrelin_off Int. Strength	ghrelin_on Int. Strength	ghrelin_off Hub1?	ghrelin_on Hub1?	ghrelin_off Hub2?	ghrelin_on Hub2?	ConSurf1	ConSurf2
1	1x31	7x32	ghrelin_off	100	0	No	No	No	No	3	1
2	1x36	2x61	ghrelin_off	100	0	No	No	No	No	6	7
3	1x47	2x54	ghrelin_off	100	0	No	No	Yes	Yes	6	6
4	1x52	8x58	ghrelin_off	100	0	No	No	No	No	6	7
5	1x53	7x53	ghrelin_off	100	0	No	No	Yes	Yes	9	9
6	1x53	8x50	ghrelin_off	100	0	No	No	Yes	Yes	9	8
7	1x54	2x44	ghrelin_off	100	0	No	No	No	No	7	6
8	1x56	8x53	ghrelin_off	100	0	No	No	No	No	8	6
9	1x57	2x44	ghrelin_off	100	0	No	No	No	No	7	6
10	1x60	8x57	ghrelin_off	100	0	Yes	Yes	No	No	5	5
11	2x39	3x46	ghrelin_off	100	0	No	No	No	No	8	8
12	2x39	3x50	ghrelin_off	100	0	No	No	Yes	No	8	9
13	2x41	4x42	ghrelin_off	100	0	No	No	No	No	5	7
14	2x42	3x42	ghrelin_off	100	0	Yes	Yes	No	No	8	8
15	2x42	4x46	ghrelin_off	100	0	Yes	Yes	No	No	8	7
16	2x59	E1x50	ghrelin_off	100	0	No	No	Yes	Yes	5	7
17	2x60	2x63	ghrelin_off	100	0	Yes	Yes	Yes	Yes	6	5
18	2x61	7x38	ghrelin_off	100	0	No	No	Yes	Yes	7	5
19	2x63	3x29	ghrelin_off	100	0	Yes	Yes	Yes	No	5	4
20	2x66	E1x49	ghrelin_off	100	0	Yes	No	Yes	No	4	4
21	E1x50	E1x52	ghrelin_off	100	0	Yes	Yes	No	No	7	6
22	3x30	3x34	ghrelin_off	100	0	Yes	No	No	No	6	5
23	3x32	Lig	ghrelin_off	100	0	No	No	Yes	Yes	6	0
24	3x39	6x44	ghrelin_off	100	0	Yes	No	Yes	Yes	9	9
25	3x40	6x44	ghrelin_off	100	0	No	No	Yes	Yes	8	9
26	3x46	6x37	ghrelin_off	100	0	No	No	No	No	8	8
27	3x49	I2x56	ghrelin_off	100	0	No	No	No	No	9	4
28	3x50	6x33	ghrelin_off	100	0	Yes	No	No	No	9	8
29	3x52	3x56	ghrelin_off	100	0	Yes	Yes	No	Yes	5	6
30	3x52	I2x52	ghrelin_off	100	0	Yes	Yes	No	No	5	5
31	3x52	I2x55	ghrelin_off	100	0	Yes	Yes	No	No	5	4
32	3x54	5x65	ghrelin_off	100	0	No	No	No	No	9	8
33	3x54	6x30	ghrelin_off	100	0	No	No	No	No	9	6
34	E2.D191	E2.D194	ghrelin_off	100	0	No	No	No	No	6	5
35	E2.E202	E2.R206	ghrelin_off	100	0	No	No	No	No	6	1
36	5x47	5x51	ghrelin_off	100	0	Yes	No	No	No	8	6
37	5x47	6x48	ghrelin_off	100	0	Yes	No	Yes	Yes	8	8
38	5x54	6x41	ghrelin_off	100	0	Yes	Yes	No	No	8	8
39	5x61	6x34	ghrelin_off	100	0	No	No	No	No	8	7
40	5x66	6x35	ghrelin_off	100	0	Yes	No	No	No	4	7
41	5x67	5x69	ghrelin_off	100	0	No	No	No	No	5	3
42	5x70	5x72	ghrelin_off	100	0	No	No	No	No	4	4
43	6x39	7x56	ghrelin_off	100	0	No	No	No	No	6	7
44	6x40	7x49	ghrelin_off	100	0	No	No	No	No	8	9
45	6x48	6x52	ghrelin_off	100	0	Yes	Yes	No	No	8	7
46	6x48	7x45	ghrelin_off	100	0	Yes	Yes	No	No	8	9
47	6x51	Lig	ghrelin_off	100	0	Yes	Yes	Yes	Yes	6	0
48	7x31	7x32	ghrelin_off	100	0	No	No	No	No	3	1
49	7x41	Lig	ghrelin_off	100	0	Yes	Yes	Yes	Yes	7	0
50	7x49	7x53	ghrelin_off	100	0	No	No	Yes	Yes	9	9
51	7x53	8x50	ghrelin_off	100	0	Yes	Yes	Yes	Yes	9	8
52	7x54	8x51	ghrelin_off	100	0	No	No	No	No	7	8
53	8x47	8x49	ghrelin_off	100	0	No	No	No	No	8	6
54	NT.F38	NT.Q36	ghrelin_off	100	0	No	No	No	No	4	5
55	2x66	NT.Q36	ghrelin_off	100	0	Yes	No	No	No	4	5
56	7x31	NT.L37	ghrelin_off	100	0	No	No	No	No	3	5
57	7x31	NT.F38	ghrelin_off	100	0	No	No	No	No	3	4
58	2x66	E2.N196	ghrelin_off	100	0	Yes	No	No	No	4	4
59	2x67	E1x49	ghrelin_off	100	0	No	No	Yes	No	3	4
60	3x50	6x27	ghrelin_off	100	0	Yes	No	No	No	9	1
61	3x50	6x30	ghrelin_off	100	0	Yes	No	No	No	9	6
62	5x40	6x55	ghrelin_off	100	0	No	Yes	Yes	Yes	5	6
63	5x64	5x67	ghrelin_off	100	0	No	No	No	No	5	5
64	6x27	6x30	ghrelin_off	100	0	No	No	No	No	1	6
65	6x48	Lig	ghrelin_off	100	0	Yes	Yes	Yes	Yes	8	0
66	6x58	7x30	ghrelin_off	100	0	Yes	No	No	No	4	4
67	7x54	8x54	ghrelin_off	100	0	No	No	No	No	7	6
68	8x58	8x60	ghrelin_off	100	0	No	No	No	No	7	0
69	1x53	7x50	ghrelin_off	50	0	No	No	No	No	9	9
70	3x39	7x49	ghrelin_off	50	0	Yes	No	No	No	9	9
71	3x53	I2x52	ghrelin_off	50	0	No	No	No	No	8	5
72	3x47	5x53	ghrelin_off	50	0	No	No	No	No	9	6
73	2x56	3x31	ghrelin_off	0	0	No	No	No	No	6	5
74	3x34	4x57	ghrelin_off	0	0	No	No	No	No	5	7
75	5x65	5x66	ghrelin_off	0	0	No	No	Yes	No	8	4
76	3x22	E2.G183	ghrelin_off	0	0	No	No	No	No	4	4
77	1x39	2x57	ghrelin_off	0	0	No	No	Yes	Yes	6	7
78	4x38	I2x57	ghrelin_off	50	0	No	No	No	No	7	7
79	4x64	E2.A204	ghrelin_off	50	0	No	No	No	No	4	4
80	5x52	5x57	ghrelin_off	50	0	No	No	No	No	3	7
81	3x30	4x59	ghrelin_off	0	0	Yes	No	No	No	6	4
82	5x35	E2.S207	ghrelin_off	50	0	No	No	No	No	4	3
83	6x36	7x53	ghrelin_off	50	0	No	No	Yes	Yes	8	9
84	3x41	4x52	ghrelin_off	0	0	No	No	No	No	6	4
85	4x64	4x65	ghrelin_off	50	0	No	No	No	No	4	4
86	6x26	6x27	ghrelin_off	50	0	No	No	No	No	5	1
87	3x44	5x49	ghrelin_off	50	0	No	No	No	No	7	5
88	6x29	6x33	ghrelin_off	50	0	No	No	No	No	5	8
89	E3.E291	E3.S294	ghrelin_off	50	0	No	No	No	No	1	0
90	E2.E197	E2.T195	ghrelin_off	50	0	No	No	No	Yes	4	3
91	5x62	5x66	ghrelin_off	0	0	No	No	Yes	No	5	4
92	2x54	7x47	ghrelin_off	0	0	Yes	Yes	No	No	6	7
93	5x69	I3.A247	ghrelin_off	50	0	No	No	No	No	3	2
94	6x53	6x54	ghrelin_off	50	0	No	No	No	No	7	4
95	5x34	5x37	ghrelin_off	50	0	No	No	No	No	2	4
96	6x31	6x32	ghrelin_off	50	0	No	Yes	No	No	5	7
97	2x66	NT.L35	ghrelin_off	50	0	Yes	No	No	No	4	4
98	7x30	7x33	ghrelin_off	50	0	No	No	No	No	4	5
99	6x58	7x29	ghrelin_off	50	0	Yes	No	No	No	4	0
100	E1x49	E1x51	ghrelin_off	50	0	Yes	No	No	No	4	3
101	1x35	7x39	ghrelin_off	0	0	No	No	No	No	4	5
102	7x27	E2.D194	ghrelin_off	50	0	No	No	No	No	0	5
103	1x45	7x51	ghrelin_off	0	0	No	No	No	No	6	6
104	3x48	5x57	ghrelin_off	0	0	No	No	No	No	7	7
105	6x58	E2x52	ghrelin_off	50	0	Yes	No	Yes	No	4	4
106	E2x52	E3.F290	ghrelin_off	50	0	Yes	No	No	No	4	1
107	4x64	5x35	ghrelin_off	0	0	No	No	No	No	4	4
108	E3.L295	NT.L37	ghrelin_off	50	0	No	No	No	No	0	5
109	6x25	6x28	ghrelin_off	50	0	No	No	No	No	2	4
110	5x69	I3.V249	ghrelin_off	50	0	No	No	No	No	3	3
111	2x62	2x67	ghrelin_off	50	0	No	No	No	No	4	3
112	2x41	I1x51	ghrelin_off	50	0	No	No	No	No	5	7
113	6x56	6x57	ghrelin_off	0	0	No	No	No	No	5	4
114	5x40	5x44	ghrelin_off	0	0	No	Yes	No	No	5	4
115	6x43	7x48	ghrelin_off	0	0	No	No	No	No	6	7
116	4x48	4x52	ghrelin_off	0	0	No	No	No	No	4	4
117	5x51	5x55	ghrelin_off	0	0	No	No	No	No	6	5
118	6x59	6x60	ghrelin_off	0	0	No	No	No	No	4	4
119	4x39	4x43	ghrelin_off	0	0	No	No	No	No	3	3
120	I2x51	I2x54	ghrelin_off	0	0	No	No	No	No	7	4
121	6x24	6x26	ghrelin_off	0	0	No	No	No	No	2	5
122	E2.E185	E2.E202	ghrelin_off	0	0	No	No	No	No	1	6
123	5x54	6x42	ghrelin_off	0	0	Yes	Yes	No	No	8	5
124	1x28	1x30	ghrelin_off	0	0	No	No	No	No	4	2
125	E2.V205	E2x52	ghrelin_off	0	0	No	No	Yes	No	4	4
126	1x40	1x44	ghrelin_off	0	0	No	No	No	No	4	5
127	I3.V248	I3.V249	ghrelin_off	0	0	No	No	No	No	3	3
128	5x37	5x38	ghrelin_off	0	0	No	No	No	No	4	6
129	5x54	6x38	ghrelin_off	0	0	Yes	Yes	No	No	8	5
130	6x61	E3.I297	ghrelin_off	0	0	No	No	No	No	2	0
131	6x28	I3.A251	ghrelin_off	0	0	No	No	No	No	4	3
132	1x40	2x57	ghrelin_off	0	0	No	No	Yes	Yes	4	7
133	4x47	4x48	ghrelin_off	0	0	No	No	No	No	4	4
134	3x23	E1x52	ghrelin_off	0	0	No	No	No	No	4	6
135	1x32	2x65	Shared	100	100	No	No	Yes	Yes	5	4
136	1x35	7x35	Shared	100	0	No	No	No	No	4	4
137	1x43	1x47	Shared	100	100	No	No	No	No	7	6
138	1x43	2x54	Shared	100	100	No	No	Yes	Yes	7	6
139	1x43	2x57	Shared	100	100	No	No	Yes	Yes	7	7
140	1x46	2x54	Shared	100	100	No	No	Yes	Yes	8	6
141	1x47	2x51	Shared	100	0	No	No	No	No	6	7
142	1x49	7x50	Shared	100	100	No	No	No	No	8	9
143	1x50	2x47	Shared	100	100	No	No	No	No	9	9
144	1x50	2x50	Shared	100	100	No	No	No	Yes	9	9
145	1x50	7x50	Shared	100	100	No	No	No	No	9	9
146	1x51	2x51	Shared	100	0	No	No	No	No	3	7
147	1x54	2x48	Shared	100	100	No	No	No	No	7	6
148	1x60	I1x49	Shared	100	100	Yes	Yes	No	No	5	6
149	1x60	I1x50	Shared	100	66.6667	Yes	Yes	No	No	5	8
150	1x60	8x53	Shared	100	100	Yes	Yes	No	No	5	6
151	1x60	8x56	Shared	100	100	Yes	Yes	No	No	5	3
152	8x49	I1x50	Shared	100	0	No	No	No	No	6	8
153	2x37	2x40	Shared	100	100	No	No	No	No	7	8
154	2x38	3x49	Shared	100	100	No	No	No	No	7	9
155	2x38	4x42	Shared	100	100	No	No	No	No	7	7
156	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	7
157	2x42	3x46	Shared	100	100	Yes	Yes	No	No	8	8
158	2x42	3x49	Shared	100	100	Yes	Yes	No	No	8	9
159	2x42	4x42	Shared	100	100	Yes	Yes	No	No	8	7
160	2x42	4x45	Shared	100	100	Yes	Yes	No	No	8	6
161	2x43	7x53	Shared	100	100	No	No	Yes	Yes	8	9
162	2x45	4x46	Shared	100	100	No	No	No	No	9	7
163	2x46	3x42	Shared	100	100	No	No	No	No	9	8
164	2x46	3x43	Shared	100	100	No	No	No	Yes	9	8
165	2x48	2x52	Shared	100	100	No	No	No	Yes	6	7
166	2x49	3x39	Shared	100	100	No	No	Yes	No	8	9
167	2x50	3x39	Shared	100	100	No	Yes	Yes	No	9	9
168	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
169	2x52	3x35	Shared	100	100	No	Yes	No	No	7	8
170	2x53	3x35	Shared	100	100	No	No	No	No	7	8
171	2x53	7x41	Shared	100	100	No	No	Yes	Yes	7	7
172	2x54	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
173	2x54	7x46	Shared	100	100	Yes	Yes	No	No	6	9
174	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	7
175	2x59	3x28	Shared	100	100	No	No	Yes	Yes	5	4
176	2x60	7x38	Shared	100	100	Yes	Yes	Yes	Yes	6	5
177	2x60	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
178	2x60	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
179	2x63	3x28	Shared	100	100	Yes	Yes	Yes	Yes	5	4
180	2x63	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
181	2x64	7x38	Shared	100	100	No	No	Yes	Yes	4	5
182	2x65	2x66	Shared	100	33.3333	Yes	Yes	Yes	No	4	4
183	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	7	9
184	E1x51	E2.W193	Shared	100	33.3333	No	No	No	No	3	4
185	3x24	E1x52	Shared	100	100	No	No	No	No	5	6
186	3x22	3x26	Shared	100	100	No	No	No	No	4	7
187	3x22	E2.V184	Shared	100	100	No	No	No	No	4	5
188	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
189	3x26	4x62	Shared	100	100	No	No	No	No	7	5
190	3x28	3x29	Shared	100	100	Yes	Yes	Yes	No	4	4
191	3x29	4x65	Shared	100	100	Yes	No	No	No	4	4
192	3x29	Lig	Shared	100	100	Yes	No	Yes	Yes	4	0
193	3x30	4x54	Shared	100	100	Yes	No	No	No	6	4
194	3x30	4x62	Shared	100	100	Yes	No	No	No	6	5
195	3x33	3x37	Shared	100	100	No	Yes	No	No	4	6
196	3x33	4x61	Shared	100	100	No	Yes	No	No	4	4
197	3x33	6x55	Shared	100	100	No	Yes	Yes	Yes	4	6
198	3x34	4x54	Shared	100	100	No	No	No	No	5	4
199	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	8
200	3x37	5x46	Shared	100	100	No	No	No	No	6	6
201	3x38	4x50	Shared	100	100	No	No	No	Yes	6	9
202	3x40	5x50	Shared	100	100	No	No	No	Yes	8	9
203	3x41	4x49	Shared	100	100	No	No	No	No	6	7
204	3x41	5x46	Shared	100	100	No	No	No	No	6	6
205	3x43	6x44	Shared	100	100	No	Yes	Yes	Yes	8	9
206	3x47	5x58	Shared	100	100	No	No	Yes	Yes	9	9
207	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	7
208	3x51	5x57	Shared	100	100	Yes	Yes	No	No	8	7
209	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	5
210	3x51	5x61	Shared	100	33.3333	Yes	Yes	No	No	8	8
211	4x50	4x54	Shared	100	100	No	Yes	No	No	9	4
212	4x56	5x46	Shared	100	100	No	No	No	No	5	6
213	4x59	4x60	Shared	100	100	No	No	No	No	4	7
214	4x60	5x39	Shared	100	100	No	No	No	Yes	7	5
215	E2.E185	E2x51	Shared	100	100	No	No	No	Yes	1	3
216	E2.E185	E2.T201	Shared	100	100	No	No	No	No	1	3
217	E2.H186	E2.P192	Shared	100	66.6667	No	No	No	No	2	1
218	E2.E187	E2.T190	Shared	100	100	No	No	No	No	3	3
219	E2.T190	E2.T195	Shared	100	100	No	No	No	Yes	3	3
220	E2.E197	E2x51	Shared	100	100	No	No	No	Yes	4	3
221	5x36	E2x52	Shared	100	100	No	No	Yes	No	3	4
222	E2.F203	E2.S207	Shared	100	33.3333	No	No	No	No	6	3
223	5x39	5x42	Shared	100	33.3333	No	Yes	No	No	5	5
224	5x40	6x59	Shared	100	100	No	Yes	No	No	5	4
225	5x47	5x48	Shared	100	100	Yes	No	No	No	8	4
226	5x47	6x52	Shared	100	100	Yes	No	No	No	8	7
227	5x51	6x45	Shared	100	33.3333	No	No	No	No	6	6
228	5x52	5x56	Shared	100	33.3333	No	No	No	No	3	4
229	5x54	5x58	Shared	100	100	Yes	Yes	Yes	Yes	8	9
230	5x58	6x37	Shared	100	100	Yes	Yes	No	No	9	8
231	5x58	6x41	Shared	100	100	Yes	Yes	No	No	9	8
232	5x66	6x31	Shared	100	100	Yes	No	No	Yes	4	5
233	6x36	7x56	Shared	100	100	No	No	No	No	8	7
234	6x39	7x52	Shared	100	33.3333	No	No	No	Yes	6	8
235	6x42	6x46	Shared	100	0	No	No	No	No	5	5
236	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
237	6x47	7x45	Shared	100	100	No	No	No	No	9	9
238	6x48	7x41	Shared	100	100	Yes	Yes	Yes	Yes	8	7
239	6x50	7x40	Shared	100	66.6667	No	No	No	No	9	7
240	6x51	6x52	Shared	100	100	Yes	Yes	No	No	6	7
241	6x51	6x55	Shared	100	100	Yes	Yes	Yes	Yes	6	6
242	6x51	7x41	Shared	100	100	Yes	Yes	Yes	Yes	6	7
243	6x55	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
244	6x58	E3.F290	Shared	100	100	Yes	No	No	No	4	1
245	6x60	E3.E291	Shared	100	100	No	No	No	No	4	1
246	7x38	7x42	Shared	100	100	Yes	Yes	Yes	Yes	5	7
247	7x38	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
248	7x41	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	7
249	7x48	7x52	Shared	100	33.3333	No	No	No	Yes	7	8
250	7x54	8x50	Shared	100	100	No	No	Yes	Yes	7	8
251	8x48	8x51	Shared	100	33.3333	No	No	No	No	5	8
252	8x50	8x54	Shared	100	100	Yes	Yes	No	No	8	6
253	8x51	8x55	Shared	100	0	No	No	No	No	8	3
254	7x35	NT.F38	Shared	100	100	No	No	No	No	4	4
255	1x36	2x65	Shared	100	100	No	No	Yes	Yes	6	4
256	E1x49	E1x50	Shared	100	33.3333	Yes	No	Yes	Yes	4	7
257	6x56	6x60	Shared	100	100	No	No	No	No	5	4
258	8x55	8x60	Shared	100	33.3333	No	No	No	No	3	0
259	3x44	5x50	Shared	50	100	No	No	No	Yes	7	9
260	4x40	4x43	Shared	50	0	No	No	No	No	4	3
261	1x42	7x43	Shared	50	100	No	No	No	No	7	5
262	2x40	I1x50	Shared	50	100	No	No	No	No	8	8
263	7x28	7x32	Shared	50	33.3333	No	No	No	No	0	1
264	2x57	2x58	Shared	0	33.3333	Yes	Yes	No	No	7	7
265	5x43	6x55	Shared	50	100	No	No	Yes	Yes	6	6
266	6x49	6x50	Shared	0	66.6667	No	No	No	No	6	9
267	4x41	I2x56	Shared	50	100	No	No	No	No	5	4
268	3x55	5x64	Shared	0	66.6667	No	No	No	No	7	5
269	E2.D191	E2.P192	Shared	50	100	No	No	No	No	6	1
270	2x37	2x39	Shared	50	33.3333	No	No	No	No	7	8
271	2x49	4x50	Shared	50	100	No	No	No	Yes	8	9
272	1x59	8x57	Shared	50	100	No	No	No	No	5	5
273	6x49	6x53	Shared	0	33.3333	No	No	No	No	6	7
274	3x54	5x61	Shared	50	100	No	No	No	No	9	8
275	E2x51	E2x52	Shared	0	0	No	Yes	Yes	No	3	4
276	2x67	E2.E197	Shared	50	100	No	No	No	No	3	4
277	2x56	3x28	Shared	50	33.3333	No	No	Yes	Yes	6	4
278	E2.H186	E2.T195	Shared	50	33.3333	No	No	No	Yes	2	3
279	I1x48	I1x51	Shared	50	100	No	No	No	No	6	7
280	3x51	3x52	Shared	50	33.3333	Yes	Yes	Yes	Yes	8	5
281	3x21	3x24	Shared	50	33.3333	No	No	No	No	8	5
282	3x27	4x62	Shared	0	0	No	No	No	No	5	5
283	5x47	6x49	Shared	50	100	Yes	No	No	No	8	6
284	1x42	7x47	Shared	50	0	No	No	No	No	7	7
285	E3.E291	E3.P292	Shared	0	100	No	No	No	No	1	2
286	E3.I297	E3.S294	Shared	50	100	No	No	No	No	0	0
287	8x48	8x52	Shared	0	33.3333	No	No	No	No	5	4
288	7x37	Lig	Shared	50	100	No	No	Yes	Yes	7	0
289	7x30	7x34	Shared	50	100	No	No	No	No	4	4
290	7x51	7x55	Shared	0	0	No	No	No	No	6	6
291	E1.R107	E1x49	Shared	0	100	No	No	Yes	No	4	4
292	5x45	5x49	Shared	50	33.3333	No	No	No	No	5	5
293	2x41	4x39	Shared	0	0	No	No	No	No	5	3
294	1x48	1x49	Shared	0	0	No	No	No	No	3	8
295	1x29	1x30	Shared	0	0	No	No	No	No	2	2
296	3x38	4x53	Shared	0	0	No	No	No	No	6	8
297	1x28	1x31	Shared	0	66.6667	No	No	No	No	4	3
298	I2x50	I2x51	Shared	0	66.6667	No	No	No	No	8	7
299	4x63	5x35	Shared	0	0	No	No	No	No	4	4
300	7x36	7x40	Shared	0	33.3333	No	No	No	No	5	7
301	1x38	1x42	Shared	0	0	No	No	No	No	5	7
302	7x55	7x56	Shared	0	100	No	No	No	No	6	7
303	3x56	I2x50	Shared	0	0	No	Yes	No	No	6	8
304	2x52	2x55	Shared	0	0	No	Yes	No	No	7	5
305	1x55	8x57	Shared	0	33.3333	No	No	No	No	3	5
306	1x33	2x65	Shared	0	0	No	No	Yes	Yes	4	4
307	5x60	5x63	Shared	0	100	No	No	No	No	5	4
308	1x33	1x34	Shared	0	0	No	No	No	No	4	6
309	8x58	8x59	Shared	0	33.3333	No	No	No	No	7	5
310	5x38	5x42	Shared	0	100	No	No	No	No	6	5
311	5x70	5x71	Shared	0	0	No	No	No	No	4	1
312	5x59	5x60	Shared	0	0	No	No	No	No	4	5
313	4x44	4x48	Shared	0	33.3333	No	No	No	No	3	4
314	E3.E296	E3.S294	Shared	0	33.3333	No	No	No	No	0	0
315	4x38	4x41	Shared	0	33.3333	No	No	No	No	7	5
316	1x32	2x64	ghrelin_on	0	100	No	No	No	No	5	4
317	1x52	8x50	ghrelin_on	0	100	No	No	Yes	Yes	6	8
318	1x52	8x54	ghrelin_on	0	100	No	No	No	No	6	6
319	1x56	8x50	ghrelin_on	0	100	No	No	Yes	Yes	8	8
320	1x57	2x40	ghrelin_on	0	100	No	No	No	No	7	8
321	1x59	1x60	ghrelin_on	0	100	No	No	Yes	Yes	5	5
322	2x39	3x49	ghrelin_on	0	100	No	No	No	No	8	9
323	2x43	7x54	ghrelin_on	0	100	No	No	No	No	8	7
324	2x45	4x50	ghrelin_on	0	100	No	No	No	Yes	9	9
325	2x46	7x49	ghrelin_on	0	100	No	No	No	No	9	9
326	2x49	3x35	ghrelin_on	0	100	No	No	No	No	8	8
327	2x50	7x49	ghrelin_on	0	100	No	Yes	No	No	9	9
328	2x57	2x61	ghrelin_on	0	100	Yes	Yes	No	No	7	7
329	2x60	3x28	ghrelin_on	0	100	Yes	Yes	Yes	Yes	6	4
330	2x63	E1x50	ghrelin_on	0	100	Yes	Yes	Yes	Yes	5	7
331	2x64	Lig	ghrelin_on	0	100	No	No	Yes	Yes	4	0
332	2x67	Lig	ghrelin_on	0	100	No	No	Yes	Yes	3	0
333	3x25	E1x50	ghrelin_on	0	100	No	No	Yes	Yes	9	7
334	3x23	3x26	ghrelin_on	0	100	No	No	No	No	4	7
335	3x33	Lig	ghrelin_on	0	100	No	Yes	Yes	Yes	4	0
336	3x36	7x41	ghrelin_on	0	100	No	No	Yes	Yes	7	7
337	3x37	5x43	ghrelin_on	0	100	No	No	No	No	6	6
338	3x40	6x48	ghrelin_on	0	100	No	No	Yes	Yes	8	8
339	3x43	5x54	ghrelin_on	0	100	No	Yes	Yes	Yes	8	8
340	3x43	7x53	ghrelin_on	0	100	No	Yes	Yes	Yes	8	9
341	3x44	5x53	ghrelin_on	0	100	No	No	No	No	7	6
342	3x46	7x53	ghrelin_on	0	100	No	No	Yes	Yes	8	9
343	3x47	5x54	ghrelin_on	0	100	No	No	Yes	Yes	9	8
344	3x47	5x57	ghrelin_on	0	100	No	No	No	No	9	7
345	3x48	3x52	ghrelin_on	0	100	No	No	Yes	Yes	7	5
346	3x50	5x58	ghrelin_on	0	100	Yes	No	Yes	Yes	9	9
347	3x50	7x53	ghrelin_on	0	100	Yes	No	Yes	Yes	9	9
348	3x51	3x56	ghrelin_on	0	100	Yes	Yes	No	Yes	8	6
349	3x55	3x56	ghrelin_on	0	100	No	No	No	Yes	7	6
350	3x56	I2x52	ghrelin_on	0	100	No	Yes	No	No	6	5
351	4x61	Lig	ghrelin_on	0	100	No	No	Yes	Yes	4	0
352	4x64	5x39	ghrelin_on	0	100	No	No	No	Yes	4	5
353	4x64	Lig	ghrelin_on	0	100	No	No	Yes	Yes	4	0
354	E2.N196	E2.V184	ghrelin_on	0	100	No	No	No	No	4	5
355	E2.H186	E2.N196	ghrelin_on	0	100	No	No	No	No	2	4
356	E2.E197	Lig	ghrelin_on	0	100	No	No	Yes	Yes	4	0
357	E2.E202	E2x51	ghrelin_on	0	100	No	No	No	Yes	6	3
358	E2.F203	E2.R206	ghrelin_on	0	100	No	No	No	No	6	1
359	E2.V205	E3.F290	ghrelin_on	0	100	No	No	No	No	4	1
360	5x39	Lig	ghrelin_on	0	100	No	Yes	Yes	Yes	5	0
361	5x40	5x41	ghrelin_on	0	100	No	Yes	No	No	5	4
362	5x43	6x52	ghrelin_on	0	100	No	No	No	No	6	7
363	5x44	5x48	ghrelin_on	0	100	No	No	No	No	4	4
364	5x49	5x50	ghrelin_on	0	100	No	No	No	Yes	5	9
365	5x50	6x44	ghrelin_on	0	100	No	Yes	Yes	Yes	9	9
366	5x54	6x44	ghrelin_on	0	100	Yes	Yes	Yes	Yes	8	9
367	5x63	5x67	ghrelin_on	0	100	No	No	No	No	4	5
368	5x64	5x68	ghrelin_on	0	100	No	No	No	No	5	5
369	5x65	6x30	ghrelin_on	0	100	No	No	No	No	8	6
370	6x32	6x35	ghrelin_on	0	100	No	No	No	No	7	7
371	6x40	7x52	ghrelin_on	0	100	No	No	No	Yes	8	8
372	6x40	7x53	ghrelin_on	0	100	No	No	Yes	Yes	8	9
373	6x48	6x51	ghrelin_on	0	100	Yes	Yes	Yes	Yes	8	6
374	6x51	7x37	ghrelin_on	0	100	Yes	Yes	No	No	6	7
375	6x54	7x34	ghrelin_on	0	100	No	No	No	No	4	4
376	6x58	Lig	ghrelin_on	0	100	Yes	No	Yes	Yes	4	0
377	6x61	Lig	ghrelin_on	0	100	No	No	Yes	Yes	2	0
378	E3.F290	Lig	ghrelin_on	0	100	No	No	Yes	Yes	1	0
379	E3.L295	Lig	ghrelin_on	0	100	No	No	Yes	Yes	0	0
380	7x31	Lig	ghrelin_on	0	100	No	No	Yes	Yes	3	0
381	7x34	Lig	ghrelin_on	0	100	No	No	Yes	Yes	4	0
382	7x43	7x48	ghrelin_on	0	100	No	No	No	No	5	7
383	8x55	8x61	ghrelin_on	0	100	No	No	No	No	3	0
384	Lig	Lig	ghrelin_on	0	100	Yes	Yes	Yes	Yes	0	0
385	E2.E187	E2.T195	ghrelin_on	0	100	No	No	No	Yes	3	3
386	E2.E202	E2.V205	ghrelin_on	0	100	No	No	No	No	6	4
387	5x35	E2.A204	ghrelin_on	0	100	No	No	No	No	4	4
388	6x31	6x35	ghrelin_on	0	100	No	Yes	No	No	5	7
389	6x27	6x29	ghrelin_on	0	100	No	No	No	No	1	5
390	5x51	6x44	ghrelin_on	0	33.3333	No	No	Yes	Yes	6	9
391	5x68	6x30	ghrelin_on	0	33.3333	No	No	No	No	5	6
392	6x26	6x30	ghrelin_on	0	33.3333	No	No	No	No	5	6
393	6x57	7x30	ghrelin_on	0	33.3333	No	No	No	No	4	4
394	5x69	6x31	ghrelin_on	0	33.3333	No	No	No	Yes	3	5
395	2x56	3x32	ghrelin_on	0	66.6667	No	No	No	No	6	6
396	6x57	7x29	ghrelin_on	0	0	No	No	No	No	4	0
397	NT.F38	NT.L37	ghrelin_on	0	33.3333	No	No	No	No	4	5
398	5x69	6x26	ghrelin_on	0	33.3333	No	No	No	No	3	5
399	2x59	E1x52	ghrelin_on	0	33.3333	No	No	No	No	5	6
400	1x39	7x38	ghrelin_on	0	0	No	No	Yes	Yes	6	5
401	3x30	4x57	ghrelin_on	0	0	Yes	No	No	No	6	7
402	6x47	6x48	ghrelin_on	0	66.6667	No	No	Yes	Yes	9	8
403	6x54	7x33	ghrelin_on	0	33.3333	No	No	No	No	4	5
404	7x28	7x31	ghrelin_on	0	33.3333	No	No	No	No	0	3
405	8x47	8x50	ghrelin_on	0	0	No	No	Yes	Yes	8	8
406	2x38	4x39	ghrelin_on	0	33.3333	No	No	No	No	7	3
407	5x56	5x57	ghrelin_on	0	33.3333	No	No	No	No	4	7
408	2x52	3x31	ghrelin_on	0	66.6667	No	Yes	No	No	7	5
409	5x34	E2.S207	ghrelin_on	0	66.6667	No	No	No	No	2	3
410	5x65	6x33	ghrelin_on	0	0	No	No	No	No	8	8
411	1x53	7x54	ghrelin_on	0	0	No	No	No	No	9	7
412	E2.D194	E2.T195	ghrelin_on	0	33.3333	No	No	No	Yes	5	3
413	7x32	NT.F38	ghrelin_on	0	33.3333	No	No	No	No	1	4
414	5x40	Lig	ghrelin_on	0	33.3333	No	Yes	Yes	Yes	5	0
415	5x61	5x62	ghrelin_on	0	66.6667	No	No	No	No	8	5
416	5x66	5x70	ghrelin_on	0	33.3333	Yes	No	No	No	4	4
417	Lig	NT.Q36	ghrelin_on	0	33.3333	Yes	Yes	No	No	0	5
418	1x32	NT.L35	ghrelin_on	0	33.3333	No	No	No	No	5	4
419	E2.D191	E2.W193	ghrelin_on	0	33.3333	No	No	No	No	6	4
420	4x52	4x56	ghrelin_on	0	0	No	No	No	No	4	5
421	5x40	6x56	ghrelin_on	0	33.3333	No	Yes	No	No	5	5
422	7x56	8x51	ghrelin_on	0	33.3333	No	No	No	No	7	8
423	5x69	6x27	ghrelin_on	0	33.3333	No	No	No	No	3	1
424	5x35	5x38	ghrelin_on	0	33.3333	No	No	No	No	4	6
425	4x43	4x44	ghrelin_on	0	33.3333	No	No	No	No	3	3
426	1x31	7x35	ghrelin_on	0	0	No	No	No	No	3	4
427	4x65	E2.G183	ghrelin_on	0	0	No	No	No	No	4	4
428	5x62	6x34	ghrelin_on	0	0	No	No	No	No	5	7
429	1x57	I1x51	ghrelin_on	0	0	No	No	No	No	7	7
430	2x62	2x63	ghrelin_on	0	33.3333	No	No	Yes	Yes	4	5
431	5x37	6x59	ghrelin_on	0	33.3333	No	No	No	No	4	4
432	5x55	6x41	ghrelin_on	0	0	No	No	No	No	5	8
433	2x41	2x44	ghrelin_on	0	33.3333	No	No	No	No	5	6
434	8x54	8x58	ghrelin_on	0	0	No	No	No	No	6	7
435	6x60	E3.I297	ghrelin_on	0	33.3333	No	No	No	No	4	0
436	6x46	7x40	ghrelin_on	0	0	No	No	No	No	5	7
437	6x25	6x29	ghrelin_on	0	33.3333	No	No	No	No	2	5
438	6x28	6x31	ghrelin_on	0	33.3333	No	No	No	Yes	4	5
439	7x38	7x39	ghrelin_on	0	0	Yes	Yes	No	No	5	5
440	1x45	1x46	ghrelin_on	0	0	No	No	No	No	6	8
441	4x55	4x56	ghrelin_on	0	33.3333	No	No	No	No	5	5
442	6x61	7x27	ghrelin_on	0	33.3333	No	No	No	No	2	0
443	I2x56	I2x57	ghrelin_on	0	0	No	No	No	No	4	7
444	I2x55	I2x56	ghrelin_on	0	0	No	No	No	No	4	4
445	4x42	I2x57	ghrelin_on	0	0	No	No	No	No	7	7
446	6x43	7x52	ghrelin_on	0	0	No	No	No	Yes	6	8
447	1x29	NT.L35	ghrelin_on	0	0	No	No	No	No	2	4
448	7x48	7x51	ghrelin_on	0	0	No	No	No	No	7	6
449	3x52	I2x53	ghrelin_on	0	0	Yes	Yes	No	No	5	6
450	E2.F203	E2.T201	ghrelin_on	0	0	No	No	No	No	6	3
451	4x43	4x47	ghrelin_on	0	0	No	No	No	No	3	4
452	1x34	1x37	ghrelin_on	0	0	No	No	No	No	6	5
453	4x38	4x40	ghrelin_on	0	0	No	No	No	No	7	4
454	3x53	I2x53	ghrelin_on	0	0	No	No	No	No	8	6
455	1x44	1x45	ghrelin_on	0	0	No	No	No	No	5	6
456	1x55	1x58	ghrelin_on	0	0	No	No	No	No	3	3
457	1x40	2x61	ghrelin_on	0	0	No	No	No	No	4	7
458	6x38	6x42	ghrelin_on	0	0	No	No	No	No	5	5
459	E2.E185	E2.N188	ghrelin_on	0	0	No	No	No	No	1	0
460	E2.E202	E2.N188	ghrelin_on	0	0	No	No	No	No	6	0
461	3x52	I2x54	ghrelin_on	0	0	Yes	Yes	No	No	5	4

Orange: nodes, hubs and links specific of ghrelin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ghrelin_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	ghrelin_off Avg Int. Strength	ghrelin_on Avg Int. Strength	ghrelin_off Num Of Links	ghrelin_on Num Of Links	ConSurf
1	2x66	ghrelin_off	0	0	5	1	4
2	E1x49	ghrelin_off	0	0	5	2	4
3	3x29	ghrelin_off	50	66.6667	4	3	4
4	3x30	ghrelin_off	0	0	4	3	6
5	3x39	ghrelin_off	50	33.3333	4	2	9
6	3x50	ghrelin_off	50	0	4	2	9
7	E2x52	ghrelin_off	50	0	5	2	4
8	5x47	ghrelin_off	100	33.3333	5	3	8
9	5x66	ghrelin_off	0	0	4	2	4
10	6x58	ghrelin_off	0	0	4	2	4
11	1x60	Shared	50	33.3333	5	5	5
12	2x42	Shared	100	100	7	5	8
13	2x54	Shared	100	100	6	4	6
14	2x57	Shared	0	33.3333	5	4	7
15	2x60	Shared	100	33.3333	4	4	6
16	2x63	Shared	50	33.3333	4	4	5
17	2x65	Shared	0	0	4	4	4
18	E1x50	Shared	50	66.6667	4	4	7
19	3x28	Shared	100	66.6667	4	5	4
20	3x51	Shared	100	100	5	6	8
21	3x52	Shared	0	0	4	4	5
22	5x54	Shared	50	33.3333	4	4	8
23	5x58	Shared	50	100	4	5	9
24	6x44	Shared	100	66.6667	4	5	9
25	6x48	Shared	100	100	7	6	8
26	6x51	Shared	100	66.6667	4	5	6
27	6x55	Shared	0	100	5	4	6
28	7x38	Shared	100	0	5	6	5
29	7x41	Shared	50	100	5	5	7
30	7x42	Shared	100	100	5	5	7
31	7x53	Shared	100	66.6667	5	5	9
32	8x50	Shared	100	33.3333	4	5	8
33	Lig	Shared	100	100	10	23	0
34	2x50	ghrelin_on	0	66.6667	3	4	9
35	2x52	ghrelin_on	0	0	3	4	7
36	3x33	ghrelin_on	0	66.6667	3	4	4
37	3x43	ghrelin_on	0	33.3333	2	4	8
38	3x56	ghrelin_on	0	0	2	4	6
39	4x50	ghrelin_on	50	33.3333	3	4	9
40	E2.T195	ghrelin_on	0	0	3	4	3
41	E2x51	ghrelin_on	0	0	3	4	3
42	5x39	ghrelin_on	0	33.3333	2	4	5
43	5x40	ghrelin_on	0	0	3	4	5
44	5x50	ghrelin_on	0	33.3333	2	4	9
45	6x31	ghrelin_on	0	0	2	4	5
46	7x52	ghrelin_on	0	0	2	4	8

Orange: nodes, hubs and links specific of ghrelin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ghrelin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ghrelin_off Recurrence	ghrelin_on Recurrence	ghrelin_off Hub1?	ghrelin_on Hub1?	ghrelin_off Hub2?	ghrelin_on Hub2?	ConSurf1	ConSurf2
1	NT.F38	NT.Q36	ghrelin_off	13.8321	0	No	No	No	No	4	5
2	2x66	NT.Q36	ghrelin_off	14.7745	0	Yes	No	No	No	4	5
3	2x65	2x66	ghrelin_off	18.7478	1.97628	Yes	Yes	Yes	No	4	4
4	1x36	2x65	ghrelin_off	21.6417	1.97628	No	No	Yes	Yes	6	4
5	1x36	2x61	ghrelin_off	22.4747	0	No	No	No	No	6	7
6	2x61	7x38	ghrelin_off	23.1239	0	No	No	Yes	Yes	7	5
7	2x57	7x42	ghrelin_off	10.637	9.39591	Yes	Yes	Yes	Yes	7	7
8	2x54	7x46	ghrelin_off	12.5142	9.10025	Yes	Yes	No	No	6	9
9	2x50	7x46	ghrelin_off	12.0684	8.84815	No	Yes	No	No	9	9
10	6x48	Lig	ghrelin_off	86.3283	0	Yes	Yes	Yes	Yes	8	0
11	3x39	6x44	ghrelin_off	58.5116	0	Yes	No	Yes	Yes	9	9
12	3x39	7x49	ghrelin_off	30.2648	0	Yes	No	No	No	9	9
13	7x49	7x53	ghrelin_off	28.0044	0	No	No	Yes	Yes	9	9
14	7x53	8x50	ghrelin_off	13.7812	0	Yes	Yes	Yes	Yes	9	8
15	7x54	8x50	ghrelin_off	12.2874	8.76101	No	No	Yes	Yes	7	8
16	7x54	8x51	ghrelin_off	10.9577	0	No	No	No	No	7	8
17	2x46	3x42	ghrelin_off	81.6315	1.37562	No	No	No	No	9	8
18	2x42	3x42	ghrelin_off	80.9354	0	Yes	Yes	No	No	8	8
19	2x39	3x46	ghrelin_off	58.1088	0	No	No	No	No	8	8
20	2x39	3x50	ghrelin_off	44.3276	0	No	No	Yes	No	8	9
21	E1x49	E1x50	ghrelin_off	49.6969	3.86543	Yes	No	Yes	Yes	4	7
22	2x59	E1x50	ghrelin_off	59.9703	0	No	No	Yes	Yes	5	7
23	2x59	3x28	ghrelin_off	61.5619	7.14575	No	No	Yes	Yes	5	4
24	2x63	3x28	ghrelin_off	34.1754	3.99303	Yes	Yes	Yes	Yes	5	4
25	3x28	3x29	ghrelin_off	31.8016	3.22741	Yes	Yes	Yes	No	4	4
26	3x33	6x55	ghrelin_off	16.6986	5.00763	No	Yes	Yes	Yes	4	6
27	3x33	3x37	ghrelin_off	13.9338	7.41963	No	Yes	No	No	4	6
28	3x46	6x37	ghrelin_off	11.7516	0	No	No	No	No	8	8
29	5x58	6x37	ghrelin_off	10.4767	1.37251	Yes	Yes	No	No	9	8
30	3x50	6x30	ghrelin_off	38.1917	0	Yes	No	No	No	9	6
31	3x54	6x30	ghrelin_off	37.4643	0	No	No	No	No	9	6
32	3x54	5x61	ghrelin_off	29.8189	1.59036	No	No	No	No	9	8
33	3x51	5x61	ghrelin_off	27.5116	6.33345	Yes	Yes	No	No	8	8
34	3x51	3x52	ghrelin_off	10.0231	7.56279	Yes	Yes	Yes	Yes	8	5
35	2x67	E1x49	ghrelin_off	46.3963	0	No	No	Yes	No	3	4
36	2x67	E2.E197	ghrelin_off	42.6968	0.0280103	No	No	No	No	3	4
37	E2.E197	E2.T195	ghrelin_off	14.7785	0	No	No	No	Yes	4	3
38	E2x51	E2x52	ghrelin_off	17.0349	3.85609	No	Yes	Yes	No	3	4
39	5x40	6x55	ghrelin_off	17.5629	0	No	Yes	Yes	Yes	5	6
40	5x40	6x59	ghrelin_off	14.7824	3.86231	No	Yes	No	No	5	4
41	5x47	6x48	ghrelin_off	13.7187	0	Yes	No	Yes	Yes	8	8
42	6x36	7x53	ghrelin_off	11.7516	0	No	No	Yes	Yes	8	9
43	6x36	7x56	ghrelin_off	10.4767	1.42853	No	No	No	No	8	7
44	6x59	6x60	ghrelin_off	13.2768	0	No	No	No	No	4	4
45	3x29	Lig	ghrelin_off	38.0626	7.57213	Yes	No	Yes	Yes	4	0
46	2x54	7x42	Shared	19.1819	15.1629	Yes	Yes	Yes	Yes	6	7
47	7x38	Lig	Shared	20.9808	15.1567	Yes	Yes	Yes	Yes	5	0
48	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
49	7x41	7x42	Shared	14.4695	37.3378	Yes	Yes	Yes	Yes	7	7
50	2x53	7x41	Shared	11.9158	44.6889	No	No	Yes	Yes	7	7
51	2x53	3x35	Shared	10.4532	43.2293	No	No	No	No	7	8
52	3x43	6x44	Shared	83.0003	57.7947	No	Yes	Yes	Yes	8	9
53	2x46	3x43	Shared	82.3198	17.0676	No	No	No	Yes	9	8
54	2x42	3x46	Shared	66.986	49.1426	Yes	Yes	No	No	8	8
55	2x37	2x39	Shared	16.7729	20.1176	No	No	No	No	7	8
56	2x37	2x40	Shared	15.5293	18.7389	No	No	No	No	7	8
57	2x40	I1x50	Shared	14.2779	13.1617	No	No	No	No	8	8
58	1x60	I1x50	Shared	10.4767	10.6221	Yes	Yes	No	No	5	8
59	2x42	4x42	Shared	10.1873	19.9745	Yes	Yes	No	No	8	7
60	2x49	3x39	Shared	26.4401	11.1917	No	No	Yes	No	8	9
61	2x49	4x50	Shared	25.2591	43.2293	No	No	No	Yes	8	9
62	4x50	4x54	Shared	21.6691	34.7484	No	Yes	No	No	9	4
63	3x30	4x54	Shared	17.8992	31.3124	Yes	No	No	No	6	4
64	6x55	Lig	Shared	31.876	49.043	Yes	Yes	Yes	Yes	6	0
65	3x37	5x46	Shared	12.4164	13.1431	No	No	No	No	6	6
66	E2.E197	E2x51	Shared	26.7725	21.7765	No	No	No	Yes	4	3
67	2x63	Lig	Shared	30.6949	14.3195	Yes	Yes	Yes	Yes	5	0
68	2x50	3x39	Shared	14.0941	12.0071	No	Yes	Yes	No	9	9
69	6x48	7x41	Shared	14.4617	24.5433	Yes	Yes	Yes	Yes	8	7
70	1x32	2x64	ghrelin_on	0	19.1155	No	No	No	No	5	4
71	2x64	Lig	ghrelin_on	0	13.6473	No	No	Yes	Yes	4	0
72	7x31	Lig	ghrelin_on	0	15.9628	No	No	Yes	Yes	3	0
73	7x28	7x31	ghrelin_on	0	14.3911	No	No	No	No	0	3
74	7x28	7x32	ghrelin_on	1.00504	12.4988	No	No	No	No	0	1
75	7x32	NT.F38	ghrelin_on	0	10.5941	No	No	No	No	1	4
76	1x32	2x65	ghrelin_on	1.17711	11.7799	No	No	Yes	Yes	5	4
77	7x48	7x52	ghrelin_on	2.66317	20.376	No	No	No	Yes	7	8
78	6x40	7x52	ghrelin_on	0	24.4094	No	No	No	Yes	8	8
79	6x40	7x53	ghrelin_on	0	25.6232	No	No	Yes	Yes	8	9
80	3x43	7x53	ghrelin_on	0	73.4151	No	Yes	Yes	Yes	8	9
81	6x48	6x51	ghrelin_on	0	81.7653	Yes	Yes	Yes	Yes	8	6
82	6x51	6x55	ghrelin_on	3.90677	54.2591	Yes	Yes	Yes	Yes	6	6
83	6x51	7x37	ghrelin_on	0	44.6018	Yes	Yes	No	No	6	7
84	7x37	Lig	ghrelin_on	1.43131	44.3341	No	No	Yes	Yes	7	0
85	2x60	7x42	ghrelin_on	7.01185	20.8459	Yes	Yes	Yes	Yes	6	7
86	2x60	Lig	ghrelin_on	3.20676	16.7408	Yes	Yes	Yes	Yes	6	0
87	7x38	7x42	ghrelin_on	8.57612	22.6821	Yes	Yes	Yes	Yes	5	7
88	2x43	7x54	ghrelin_on	0	11.562	No	No	No	No	8	7
89	2x43	7x53	ghrelin_on	1.32963	12.9065	No	No	Yes	Yes	8	9
90	6x51	7x41	ghrelin_on	3.44922	21.2225	Yes	Yes	Yes	Yes	6	7
91	2x39	3x49	ghrelin_on	0	21.4839	No	No	No	No	8	9
92	2x42	3x49	ghrelin_on	6.97274	26.9179	Yes	Yes	No	No	8	9
93	3x46	7x53	ghrelin_on	0	50.3377	No	No	Yes	Yes	8	9
94	2x49	3x35	ghrelin_on	0	34.4527	No	No	No	No	8	8
95	2x50	7x49	ghrelin_on	0	15.5426	No	Yes	No	No	9	9
96	E2.E197	Lig	ghrelin_on	0	23.3202	No	No	Yes	Yes	4	0
97	3x22	3x26	ghrelin_on	3.98498	20.8552	No	No	No	No	4	7
98	3x26	4x62	ghrelin_on	5.29897	24.3659	No	No	No	No	7	5
99	3x30	4x62	ghrelin_on	7.90348	27.8516	Yes	No	No	No	6	5
100	3x22	E2.V184	ghrelin_on	1.33354	19.0906	No	No	No	No	4	5
101	5x54	6x44	ghrelin_on	0	38.7912	Yes	Yes	Yes	Yes	8	9
102	3x47	5x54	ghrelin_on	0	46.8053	No	No	Yes	Yes	9	8
103	3x47	5x57	ghrelin_on	0	54.2	No	No	No	No	9	7
104	3x51	5x57	ghrelin_on	5.29897	50.1105	Yes	Yes	No	No	8	7
105	3x51	3x55	ghrelin_on	8.31802	24.4499	Yes	Yes	No	No	8	7
106	5x39	Lig	ghrelin_on	0	15.0633	No	Yes	Yes	Yes	5	0
107	E2.N196	E2.V184	ghrelin_on	0	17.3197	No	No	No	No	4	5
108	E2.E185	E2x51	ghrelin_on	8.08338	13.0528	No	No	No	Yes	1	3
109	E2.H186	E2.N196	ghrelin_on	0	15.5426	No	No	No	No	2	4
110	5x40	Lig	ghrelin_on	0	20.7245	No	Yes	Yes	Yes	5	0
111	6x51	6x52	ghrelin_on	2.36205	20.404	Yes	Yes	No	No	6	7
112	5x47	6x52	ghrelin_on	1.15756	18.7234	Yes	No	No	No	8	7
113	5x47	6x49	ghrelin_on	8.23198	13.6908	Yes	No	No	No	8	6
114	3x55	5x64	ghrelin_on	7.02749	23.1583	No	No	No	No	7	5
115	5x64	5x68	ghrelin_on	0	21.8947	No	No	No	No	5	5
116	5x68	6x30	ghrelin_on	0	20.6841	No	No	No	No	5	6
117	5x69	6x26	ghrelin_on	0	15.2221	No	No	No	No	3	5
118	6x26	6x30	ghrelin_on	0	16.4514	No	No	No	No	5	6
119	7x55	7x56	ghrelin_on	3.98498	10.7466	No	No	No	No	6	7
120	7x51	7x55	ghrelin_on	2.66317	12.1409	No	No	No	No	6	6
121	7x48	7x51	ghrelin_on	0	13.529	No	No	No	No	7	6
122	7x34	Lig	ghrelin_on	0	11.4095	No	No	Yes	Yes	4	0
123	5x40	6x56	ghrelin_on	0	13.4169	No	Yes	No	No	5	5
124	6x56	6x60	ghrelin_on	3.1481	11.5185	No	No	No	No	5	4
125	4x41	I2x56	ghrelin_on	3.57827	10.2549	No	No	No	No	5	4
126	I2x56	I2x57	ghrelin_on	0	13.1306	No	No	No	No	4	7
127	4x42	I2x57	ghrelin_on	0	14.2261	No	No	No	No	7	7
128	6x49	6x50	ghrelin_on	4.14923	10.3047	No	No	No	No	6	9
129	2x46	7x49	ghrelin_on	0	15.3123	No	No	No	No	9	9
130	3x43	5x54	ghrelin_on	0	13.6348	No	Yes	Yes	Yes	8	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	7x41	Shared	6.28	5.44333	0	0	2	1
2x60	2x63	ghrelin_off	8.34	0	1	1	1	1
2x60	7x38	Shared	12.54	8.36	1	1	1	1
2x60	7x42	Shared	7.475	4.6	1	1	1	2
2x60	Lig	Shared	20.975	4.69333	1	1	1	0
2x61	7x38	ghrelin_off	4.26	0	0	0	2	1
2x63	3x28	Shared	4.275	3.20667	1	1	1	2
2x63	3x29	ghrelin_off	5.255	0	1	1	1	1
2x63	Lig	Shared	16.375	6.19667	1	1	1	0
2x64	7x38	Shared	13.395	4.46333	0	1	1	1
2x66	E1x49	ghrelin_off	6.315	0	0	0	2	2
3x28	3x29	Shared	5.855	8.58667	1	0	2	1
3x29	4x65	Shared	4.3	9.07333	1	1	1	2
3x29	Lig	Shared	10.85	16.3033	1	1	1	0
3x32	Lig	ghrelin_off	6.525	0	0	0	1	0
3x33	3x37	Shared	7.86	9.35333	0	1	1	2
3x33	4x61	Shared	6.835	5.46667	0	1	1	1
3x33	6x55	Shared	5.815	8.92	0	1	1	1
3x36	6x48	Shared	7.88	3.23667	0	1	2	1
3x40	6x44	ghrelin_off	5.245	0	0	0	2	2
4x60	5x39	Shared	8.385	3.35333	0	0	2	1
E2.E197	E2x51	Shared	8.725	6.98	0	1	1	2
5x39	5x42	Shared	4.565	2.03	0	1	1	2
5x40	6x59	Shared	4.85	3.23	0	1	1	2
5x47	6x48	ghrelin_off	5.015	0	1	0	2	1
5x47	6x52	Shared	22.06	11.69	1	0	2	2
6x44	6x48	Shared	7.515	12.0267	0	1	2	1
6x47	7x45	Shared	4.3	5.74	0	0	2	2
6x48	6x52	ghrelin_off	11.105	0	1	1	1	2
6x48	7x41	Shared	7.515	4.67667	1	1	1	1
6x48	7x45	ghrelin_off	4.94	0	1	1	1	2
6x51	6x52	Shared	10.18	6.79	1	1	1	2
6x51	6x55	Shared	9.085	9.97667	1	1	1	1
6x51	7x41	Shared	6.43	4.28667	1	1	1	1
6x51	Lig	ghrelin_off	5.05	0	1	1	1	0
6x55	Lig	Shared	16.68	19.46	1	1	1	0
6x58	E3.F290	Shared	4.285	5.36	6	1	1	1
7x31	7x32	ghrelin_off	7.325	0	0	1	1	2
7x38	7x42	Shared	9.285	11.6933	1	1	1	2
7x38	Lig	Shared	4.635	7.24	1	1	1	0
7x41	7x42	Shared	8.765	9.63	1	1	1	2
7x41	Lig	ghrelin_off	18.19	0	1	1	1	0
NT.F38	NT.Q36	ghrelin_off	3.515	0	0	0	2	1
2x66	NT.Q36	ghrelin_off	4.48	0	0	0	2	1
7x31	NT.L37	ghrelin_off	5.325	0	0	1	1	2
7x31	NT.F38	ghrelin_off	3.515	0	0	1	1	2
2x67	E1x49	ghrelin_off	13.21	0	0	1	1	2
E1x49	E1x50	Shared	12.16	2.70333	0	0	2	2
5x40	6x55	ghrelin_off	5.885	0	0	1	1	1
6x48	Lig	ghrelin_off	9.73	0	1	1	1	0
6x58	7x30	ghrelin_off	3.965	0	6	1	1	2
7x28	7x32	Shared	3.38	2.62667	0	0	2	2
5x43	6x55	Shared	3.295	5.71	0	0	2	1
4x64	E2.A204	ghrelin_off	3.155	0	0	1	1	2
4x64	4x65	ghrelin_off	2.98	0	0	1	1	2
E2x51	E2x52	Shared	2.88	2.88	0	0	2	2
E2.E197	E2.T195	ghrelin_off	2.82	0	0	1	1	2
2x67	E2.E197	Shared	2.805	5.23667	0	1	1	1
2x56	3x28	Shared	2.795	2.32667	0	0	2	2
6x58	7x29	ghrelin_off	2.51	0	6	1	1	2
7x37	Lig	Shared	2.265	3.77667	0	1	1	0
7x30	7x34	Shared	2.235	3.47667	0	0	2	1
6x58	E2x52	ghrelin_off	2.165	0	6	1	1	2
E2x52	E3.F290	ghrelin_off	2.165	0	6	0	2	1
4x64	5x35	ghrelin_off	2.075	0	0	1	1	2
E3.L295	NT.L37	ghrelin_off	2.075	0	0	0	1	2
2x62	2x67	ghrelin_off	1.895	0	0	0	2	1
5x40	5x44	ghrelin_off	1.62	0	0	1	1	2
E2.V205	E2x52	ghrelin_off	0.885	0	0	0	2	2
6x61	E3.I297	ghrelin_off	0.775	0	0	1	1	2
1x32	2x64	ghrelin_on	0	3.23	0	0	2	1
2x60	3x28	ghrelin_on	0	5.17667	1	1	1	2
2x63	E1x50	ghrelin_on	0	7	1	1	1	2
2x64	Lig	ghrelin_on	0	6.72333	0	1	1	0
2x67	Lig	ghrelin_on	0	6.92	0	1	1	0
3x33	Lig	ghrelin_on	0	12.8733	0	1	1	0
3x36	7x41	ghrelin_on	0	5.19	0	1	2	1
3x37	5x43	ghrelin_on	0	4.24333	0	0	2	2
3x40	6x48	ghrelin_on	0	4.08667	0	0	2	1
4x61	Lig	ghrelin_on	0	4.02667	0	1	1	0
4x64	5x39	ghrelin_on	0	5.18333	0	1	1	1
4x64	Lig	ghrelin_on	0	5.58	0	1	1	0
E2.E197	Lig	ghrelin_on	0	3.35333	0	1	1	0
E2.V205	E3.F290	ghrelin_on	0	9.17333	0	0	2	1
5x39	Lig	ghrelin_on	0	5.74667	0	1	1	0
5x40	5x41	ghrelin_on	0	3.68	0	1	1	2
5x43	6x52	ghrelin_on	0	5.57667	0	0	2	2
6x48	6x51	ghrelin_on	0	9.35333	1	1	1	1
6x51	7x37	ghrelin_on	0	3.52	1	1	1	1
6x54	7x34	ghrelin_on	0	4.52333	0	0	2	1
6x58	Lig	ghrelin_on	0	16.0633	6	1	1	0
6x61	Lig	ghrelin_on	0	3.89667	0	1	1	0
E3.F290	Lig	ghrelin_on	0	3.11667	6	1	1	0
E3.L295	Lig	ghrelin_on	0	3.10667	0	0	1	0
7x31	Lig	ghrelin_on	0	8.30667	0	1	1	0
7x34	Lig	ghrelin_on	0	18.4933	0	1	1	0
5x35	E2.A204	ghrelin_on	0	3.15333	0	0	2	2
2x56	3x32	ghrelin_on	0	2.86667	0	0	2	1
NT.F38	NT.L37	ghrelin_on	0	2.84333	0	0	2	2
1x39	7x38	ghrelin_on	0	2.79	0	0	2	1
6x47	6x48	ghrelin_on	0	2.61333	0	0	2	1
7x28	7x31	ghrelin_on	0	2.56	0	0	2	1
7x32	NT.F38	ghrelin_on	0	2.40667	0	0	2	2
5x40	Lig	ghrelin_on	0	2.40667	0	1	1	0
Lig	NT.Q36	ghrelin_on	0	2.32667	1	1	0	1
5x40	6x56	ghrelin_on	0	2.10333	0	1	1	2
2x62	2x63	ghrelin_on	0	1.74333	0	0	2	1
7x38	7x39	ghrelin_on	0	1.31	1	1	1	2
6x61	7x27	ghrelin_on	0	1.14	0	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	ghrelin_off	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
	ghrelin_on	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2

Network Difference
Value	ghrelin_off	ghrelin_on
I_min	3.515	3.10333
Number of Linked Nodes	295	297
Number of Specific Nodes	6 (2.03%)	8 (2.69%)
Number of Shared Nodes	289 (97.97%)	289 (97.31%)
Number of Links	315	327
Number of Specific Links	134 (42.54%)	146 (44.65%)
Number of Shared Links	181 (57.46%)	181 (55.35%)
Number of Hubs	33	36
Number of Specific Hubs	10 (30.30%)	13 (36.11%)
Number of Shared Hubs	23 (69.70%)	23 (63.89%)
Average % Shared Neighbours (Jaccard)	43.36
Average % Shared Neighbours (Otsuka)	52.80
Average % Shared Neighbours (Overlap Coefficient)	61.86
Average % Shared Cliques (k3-6)	76.67
Graphlets Similarity	0.601454

Paths Difference
Value	ghrelin_off	ghrelin_on
Number Of Nodes in MetaPath	68	81
Specific Nodes in MetaPath	26 (38.24%)	39 (48.15%)
Shared Nodes in MetaPath	289 (97.97%)	289 (97.97%)
Number Of Links MetaPath	69	85
Specific Links in MetaPath	45 (65.22%)	61 (71.76%)
Shared Links in MetaPath	181 (57.46%)	181 (57.46%)
Number of Shortest Paths	54220	79416
Length Of Smallest Path	3	3
Average Path Length	14.099	13.0509
Length of Longest Path	33	33
Minimum Path Strength	0.7	0.593333
Average Path Strength	6.464	5.87982
Maximum Path Strength	19.5825	15.9767
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.920231	0.918898
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.33333	3.7037
Average % Of Corr. Nodes	45.9246	44.1268
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	40.7687	43.1658
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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