Orange: nodes, hubs and links specific of glp1_on_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of glp1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner glp1_on_allo Avg Int. Strength glp1_on Avg Int. Strength glp1_on_allo Num Of Links glp1_on Num Of Links ConSurf
1NT.W39 glp1_on_allo9.72512.1122435
2NT.C46 glp1_on_allo4.524.18765428
3NT.C62 glp1_on_allo6.858.70265429
4NT.V81 glp1_on_allo6.25751.55059426
5NT.C104 glp1_on_allo6.51756.24471429
6NT.R121 glp1_on_allo7.10755.20971426
7NT.P137 glp1_on_allo5.250.935423
82x47 glp1_on_allo6.50255.51549439
92x54 glp1_on_allo4.54254.40784438
103x37 glp1_on_allo7.716.79726437
114x56 glp1_on_allo10.558.84529435
125x39 glp1_on_allo5.5157.16765437
136x49 glp1_on_allo3.98256.52294429
146x51 glp1_on_allo7.5758.56265427
15E3.E373 glp1_on_allo6.3184.64373534
167x35 glp1_on_allo5.3554.63706434
177x45 glp1_on_allo5.494.11147426
187x49 glp1_on_allo6.457.87824539
197x58 glp1_on_allo3.83753.72176439
20Alloh12 glp1_on_allo19.9080500
21NT.Y42 Shared6.50257.30382446
22NT.Y69 Shared5.08754.83696466
23NT.W72 Shared7.8256.51605679
24NT.Y88 Shared7.97757.63422465
25NT.R102 Shared17.86410.8219548
26NT.W110 Shared15.5727.62569569
271x40 Shared14.5725.53365555
281x43 Shared6.775.465767
291x47 Shared6.183335.6142677
302x57 Shared9.919.22147548
312x60 Shared10.40177.64794668
322x67 Shared8.5226.63941546
332x74 Shared4.9884.16485543
34E1.Y220 Shared7.6783.76847553
353x44 Shared8.78.27735548
363x46 Shared10.6511.7299559
373x53 Shared9.03257.29147448
384x43 Shared4.773.6925546
394x46 Shared5.4285.11494557
404x50 Shared6.7868.30471549
414x60 Shared6.5128.06047558
42E2x51 Shared10.863310.3626648
435x37 Shared10.67610.6807546
445x40 Shared9.8155.96906456
456x52 Shared6.518.21559448
466x53 Shared8.5446.47306558
476x56 Shared5.826673.47725667
48Lig Shared14.534410.654736360
49NT.F61 glp1_on10.8354.28871253
50NT.R64 glp1_on10.17335.52868344
51NT.P86 glp1_on6.023335.30812358
52NT.L89 glp1_on16.244.40776255
53NT.W91 glp1_on12.32336.85859354
54NT.Y101 glp1_on33.527.30132245
55NT.F103 glp1_on9.296.74553354
56NT.W120 glp1_on6.486674.97345
571x64 glp1_on12.69336.43882347
582x46 glp1_on5.256674.39279349
593x33 glp1_on7.193333.47618345
603x38 glp1_on7.724.49632149
613x45 glp1_on9.176675.94809346
623x50 glp1_on14.5758.1225249
633x55 glp1_on6.036673.98309348
644x42 glp1_on4.933.45868245
654x52 glp1_on4.063.59985243
664x53 glp1_on11.133.50529159
674x68 glp1_on4.476675.76368346
685x36 glp1_on11.02677.62735344
696x33 glp1_on6.311.39529257
706x34 glp1_on4.281.57647145
717x34 glp1_on10.15673.08682355
727x41 glp1_on8.525.40765248
738x53 glp1_on14.48.62221248
748x58 glp1_on10.952.90529245
   
Orange: nodes, hubs and links specific of glp1_on_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of glp1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner glp1_on_allo Recurrence glp1_on Recurrence glp1_on_allo Hub1? glp1_on Hub1? glp1_on_allo Hub2? glp1_on Hub2? ConSurf1 ConSurf2
1Lig NT.W39 glp1_on_allo17.07022.63589YesYesYesNo05
2Lig NT.R121 glp1_on_allo50.81070YesYesYesNo06
3NT.R102 NT.W110 glp1_on_allo33.67391.29718YesYesYesYes89
4NT.F103 NT.W110 glp1_on_allo27.65490NoYesYesYes49
5NT.F103 NT.T105 glp1_on_allo16.04214.20911NoYesNoNo44
6NT.E107 NT.T105 glp1_on_allo14.8463.16355NoNoNoNo54
7NT.A106 NT.E107 glp1_on_allo13.64341.05777NoNoNoNo15
8NT.A106 NT.P77 glp1_on_allo12.43460NoNoNoNo14
9NT.F61 NT.P77 glp1_on_allo11.21937.31648NoYesNoNo34
10NT.F103 NT.F80 glp1_on_allo11.21931.05777NoYesNoNo44
11Lig NT.P137 glp1_on_allo11.33670YesYesYesNo03
12Alloh12 Lig glp1_on_allo10.37540YesNoYesYes00
132x54 7x53 glp1_on_allo40.64161.22389YesNoNoNo89
142x57 7x53 glp1_on_allo61.05910YesYesNoNo89
152x47 I1x50 glp1_on_allo14.17960YesNoNoNo99
161x61 7x58 glp1_on_allo21.03310NoNoYesNo89
172x54 7x58 glp1_on_allo26.40160YesNoYesNo89
182x45 3x53 glp1_on_allo12.34573.36876NoNoYesYes78
192x53 2x56 glp1_on_allo23.00350NoNoNoNo99
202x59 4x50 glp1_on_allo11.06390NoNoYesYes79
212x74 E1.Y220 glp1_on_allo10.89898.10798YesYesYesYes33
225x37 5x39 glp1_on_allo10.25161.88347YesYesYesNo67
234x56 5x39 glp1_on_allo20.35090YesNoYesNo57
243x45 4x56 glp1_on_allo15.71533.4054NoYesYesNo65
253x45 4x52 glp1_on_allo13.57680.583852NoYesNoYes63
265x53 6x49 glp1_on_allo19.40860NoNoYesNo89
273x52 5x53 glp1_on_allo26.03990NoNoNoNo68
283x52 4x46 glp1_on_allo27.34711.03579NoNoYesYes67
293x50 6x48 glp1_on_allo16.76872.20594NoYesNoNo99
304x68 5x36 glp1_on_allo12.02217.11127NoYesNoYes64
316x46 6x47 glp1_on_allo19.67515.65286NoNoNoNo89
326x47 7x53 glp1_on_allo22.38470NoNoNoNo99
335x54 6x46 glp1_on_allo12.67570NoNoNoNo98
346x44 7x57 glp1_on_allo11.22570NoNoNoNo88
356x48 7x57 glp1_on_allo14.87771.10175NoNoNoNo98
366x53 7x41 glp1_on_allo12.2956.99401YesYesNoYes88
376x56 7x41 glp1_on_allo10.73396.67888YesYesNoYes78
383x49 4x49 glp1_on_allo13.26590NoNoNoNo86
394x49 4x52 glp1_on_allo12.91053.4054NoNoNoYes63
40NT.D67 NT.R121 Shared51.105849.989NoNoYesNo96
41NT.D67 NT.W72 Shared50.214249.3294NoNoYesYes99
42NT.R102 NT.W72 Shared42.364418.0017YesYesYesYes89
432x57 3x43 Shared59.491754.8968YesYesNoNo89
442x60 3x43 Shared100100YesYesNoNo89
452x60 Lig Shared91.395195.6932YesYesYesYes80
461x61 2x47 Shared19.675117.8747NoNoYesNo89
473x53 4x46 Shared25.925716.7729YesYesYesYes87
483x49 4x46 Shared57.965526.5348NoNoYesYes87
493x46 3x49 Shared57.781527.1479YesYesNoNo98
502x56 3x46 Shared72.773465.1545NoNoYesYes99
512x56 3x43 Shared65.954965.7188NoNoNoNo99
522x49 3x53 Shared10.97516.8829NoNoYesYes88
532x53 2x57 Shared23.282753.2527NoNoYesYes98
542x53 3x50 Shared18.647154.4204NoNoNoYes99
553x46 4x50 Shared16.445161.6612YesYesYesYes99
562x74 2x75 Shared19.084912.0459YesYesNoNo33
572x75 Lig Shared20.078112.8863NoNoYesYes30
584x60 4x64 Shared23.327117.8063YesYesNoNo88
593x37 4x60 Shared28.076919.6971YesNoYesYes78
603x37 Lig Shared35.060421.4413YesNoYesYes70
615x37 Lig Shared15.404415.7738YesYesYesYes60
624x64 4x68 Shared14.35110.0867NoNoNoYes86
635x37 5x40 Shared10.730714.9481YesYesYesYes66
645x54 5x58 Shared11.393923.4543NoNoNoNo97
65Lig NT.Y88 glp1_on021.7247YesYesYesYes05
66NT.Y42 NT.Y88 glp1_on8.5414216.1378YesYesYesYes65
67NT.W87 NT.Y42 glp1_on8.2336514.8284NoNoYesYes36
68NT.E41 NT.W87 glp1_on012.6005NoNoNoNo43
69Lig NT.Y69 glp1_on053.1086YesYesYesYes06
70NT.L123 NT.Y69 glp1_on1.8244151.445NoNoYesYes56
71NT.L123 NT.R121 glp1_on0.14595350.7927NoNoYesNo56
72NT.W110 NT.W72 glp1_on026.5299YesYesYesYes99
73NT.R64 NT.W110 glp1_on017.3543NoYesYesYes49
74NT.D74 NT.R64 glp1_on6.2950212.3977NoNoNoYes34
75NT.D74 NT.F61 glp1_on010.3554NoNoNoYes33
76NT.R102 NT.W120 glp1_on017.3568YesYesNoYes85
77NT.C126 NT.C85 glp1_on2.5097610.6388NoNoNoNo99
78NT.C85 NT.P86 glp1_on012.3953NoNoNoYes98
792x67 Lig glp1_on4.5499310.7585YesYesYesYes60
801x61 2x54 glp1_on012.0362NoNoYesNo88
812x46 2x47 glp1_on2.8778118.9886NoYesYesNo99
822x46 2x50 glp1_on1.4436752.1412NoYesNoNo99
832x50 3x50 glp1_on054.01NoNoNoYes99
841x64 8x54 glp1_on4.3087910.8587NoYesNoNo75
851x64 I1x50 glp1_on012.9742NoYesNoNo79
868x50 I1x50 glp1_on9.9914320.0708NoNoNoNo99
878x47 8x50 glp1_on1.4436721.2141NoNoNoNo99
888x47 8x49 glp1_on022.3525NoNoNoNo99
892x46 8x49 glp1_on033.3602NoYesNoNo99
902x49 3x50 glp1_on021.8077NoNoNoYes89
917x41 Lig glp1_on011.2105NoYesYesYes80
923x38 4x50 glp1_on1.4024260.1344NoYesYesYes99
933x38 4x53 glp1_on055.8471NoYesNoYes99
943x45 4x53 glp1_on2.2559348.1471NoYesNoYes69
953x45 5x46 glp1_on045.0592NoYesNoNo67
963x48 5x46 glp1_on1.4246344.1285NoNoNoNo87
973x48 5x50 glp1_on5.6699641.3069NoNoNoNo89
986x45 6x49 glp1_on9.8581739.4015NoNoYesNo99
995x50 6x49 glp1_on7.0723740.3567NoNoYesNo99
1005x54 6x45 glp1_on032.5785NoNoNoNo99
1015x58 6x42 glp1_on2.8841622.416NoNoNoNo79
1025x66 6x34 glp1_on016.0718NoNoNoYes65
1035x62 5x66 glp1_on1.4436717.1516NoNoNoNo66
1045x62 6x38 glp1_on2.8841618.2142NoNoNoNo69
1056x38 6x42 glp1_on021.3729NoNoNoNo99
1068x48 8x49 glp1_on010.8587NoNoNoNo69

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
NT.E34NT.S31Shared6.342.870021
LigNT.S31glp1_on3.8535301101
LigNT.L32Shared5.644129.581101
NT.P90NT.T35glp1_on4.7305901011
LigNT.V36Shared4.006473.931101
NT.R43NT.W39Shared9.2329490021
NT.W39NT.Y88Shared13.787115.431111
LigNT.W39Shared13.316510.111101
NT.Y42NT.Y88Shared9.928245.961121
NT.F66NT.R43glp1_on4.0870600122
NT.E68NT.F66Shared3.909415.831112
NT.D67NT.R121Shared4.203538.340021
LigNT.E68Shared6.8211812.111101
NT.P86NT.Y69Shared5.45.561121
NT.L89NT.Y69glp1_on4.2058801111
NT.L123NT.Y69Shared4.689414.690111
LigNT.Y69glp1_on6.9611801101
NT.P86NT.Y88Shared7.607655.561121
NT.L89NT.P86glp1_on3.6701112
LigNT.Y88glp1_on5.0205901101
NT.L89NT.W91Shared7.6376523.921111
NT.P90NT.W91Shared5.801768.111011
LigNT.P90glp1_on4.3535301101
NT.E128NT.W91glp1_on10.262400011
LigNT.W91glp1_on7.2564701101
NT.L123NT.R121Shared6.215889.720111
1x33LigShared6.1952910.11010
1x357x35Shared9.2358812.880022
1x36LigShared8.2147113.040110
1x397x35glp1_on3.4547101112
1x397x39glp1_on4.2264701112
1x401x43Shared5.138828.941111
1x401x44Shared6.5364713.731112
1x402x68Shared10.208214.941112
1x40Ligglp1_on4.2901110
1x431x47Shared4.496473.971111
1x432x64Shared3.859415.051112
1x432x68Shared5.073538.051112
1x437x42Shared5.310599.381111
1x43LigShared8.911187.221110
1x472x60Shared7.564717.21111
1x472x61Shared3.5329441112
1x472x64Shared9.424127.571112
1x477x46Shared8.303537.631112
1x47LigShared4.038826.731110
2x603x40Shared11.075911.771111
2x603x43Shared10.138813.261112
2x603x44Shared8.1717613.381111
2x607x45Shared4.489415.171112
2x60LigShared4.4470611.631110
2x633x36glp1_on3.7900021
2x672x68Shared6.587659.681112
2x673x33Shared3.428244.961112
2x673x36Shared7.792947.21111
2x67LigShared8.7488215.991110
2x71Ligglp1_on4.6405900010
2x742x75Shared5.774718.380021
2x75LigShared14.934721.311110
E1.Q211E1.W214glp1_on4.3811800021
E1.W214LigShared20.966536.781110
3x33E2x52Shared7.2464712.970021
3x374x60Shared9.277658.761112
3x375x39Shared5.408244.121112
3x37LigShared5.7058810.291110
3x40LigShared8.6623513.841110
3x445x43Shared10.52419.671112
3x445x47glp1_on3.9835301112
3x446x53Shared10.4310.11112
4x605x39Shared12.15765.871122
E2x52LigShared6.5435314.31110
E2.R299LigShared14.710619.541010
5x37E2.N300Shared15.687112.431111
E2.N300LigShared4.295888.941110
5x375x39Shared3.937067.051112
5x375x40Shared14.406591112
5x37LigShared8.6923517.231110
5x40E3.E373Shared5.883539.30022
5x476x53Shared4.260596.831022
6x537x41Shared3.731778.881121
6x537x45Shared3.733537.061122
6x567x37Shared3.430592.481022
6x567x41Shared6.037658.161021
7x34E3.D372Shared3.7841210.721111
E3.D372LigShared4.6158813.011110
7x34LigShared8.3882416.981110
7x377x41glp1_on6.8294101021
7x38LigShared7.528827.960110
7x41Ligglp1_on5.0317601010
7x42LigShared7.7417614.41110
NT.P86NT.Y42Shared6.871186.951122
NT.Y69NT.Y88Shared5.255884.961111
NT.L89NT.Y88glp1_on4.2058801111
2x72Ligglp1_on3.4394100010
NT.E127NT.W91glp1_on3.3347100021
1x39LigShared3.080597.311110
E1.Q210E1.W214glp1_on2.7064700021
E1.Q211E1.Q213Shared2.5610.240022
NT.A70NT.Y69glp1_on2.5094100021
NT.A92NT.L89glp1_on2.3194100021
E2.G295E2.R299glp1_on2.2941200021
LigNT.V30glp1_on2.1029401101
E1.H212E1.Q213glp1_on2.0364700112
1x472x65glp1_on1.9388201112
1x371x41glp1_on1.8458800022
1x331x34glp1_on1.7917601012
1x33NT.S136glp1_on1.5223501012
7x34E3.R376glp1_on1.5047101112
1x401x41Shared1.494712.421112
2x76E1.A209glp1_on1.3076501011
7x34E3.A375Shared1.139412.771112
NT.P137NT.S136Shared1.047061.780112
2x76Ligglp1_on0.9301010
NT.P137NT.T29glp1_on0.82294100112
7x31E3.R376glp1_on0.61764701022
7x317x34glp1_on0.61764701021
NT.E128NT.S129glp1_on0.33823500012
E1.L218NT.V36glp1_on_allo04.470021
NT.E68NT.W39glp1_on_allo04.361111
NT.R121NT.Y69glp1_on_allo05.140111
LigNT.L89glp1_on_allo08.561101
NT.S94NT.W91glp1_on_allo04.940021
LigNT.R121glp1_on_allo05.231101
LigNT.L123glp1_on_allo04.471101
LigNT.E128glp1_on_allo010.81101
1x36NT.P137glp1_on_allo04.930111
LigNT.P137glp1_on_allo011.131101
1x37Alloh12glp1_on_allo021.420021
1x397x38glp1_on_allo04.151111
1x40Alloh12glp1_on_allo032.831111
1x432x67glp1_on_allo04.781111
2x72Alloh12glp1_on_allo018.710011
2x76Alloh12glp1_on_allo08.851011
E1.A209Ligglp1_on_allo04.530010
E1.Q210E1.Q211glp1_on_allo07.680022
E1.H212E1.W214glp1_on_allo09.520111
E1.H212Ligglp1_on_allo08.640110
3x36Ligglp1_on_allo09.030110
3x375x37glp1_on_allo07.671111
3x403x44glp1_on_allo03.791111
3x44Ligglp1_on_allo06.561110
E3.D372E3.E373glp1_on_allo05.21112
Alloh12Ligglp1_on_allo017.730110
2x713x33glp1_on_allo03.650012
NT.P90NT.V30glp1_on_allo03.531011
1x35NT.P137glp1_on_allo03.160021
LigNT.T35glp1_on_allo02.591101
1x442x65glp1_on_allo02.590022
E3.E373E3.R376glp1_on_allo02.330022
7x357x39glp1_on_allo02.140022

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
glp1_on 6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
glp1_on_allo 6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
Network Difference
Value glp1_on_allo glp1_on
Imin 3.79 3.35471
Number of Linked Nodes 356 392
Number of Specific Nodes 1 (0.28%) 37  (9.44%)
Number of Shared Nodes 355 (99.72%) 355  (90.56%)
Number of Links 406 433
Number of Specific Links 133 (32.76%) 160  (36.95%)
Number of Shared Links 273 (67.24%) 273  (63.05%)
Number of Hubs 48 54
Number of Specific Hubs 20 (41.67%) 26  (48.15%)
Number of Shared Hubs 28 (58.33%) 28  (51.85%)
Average % Shared Neighbours (Jaccard) 48.86
Average % Shared Neighbours (Otsuka) 58.18
Average % Shared Neighbours (Overlap Coefficient) 68.03
Average % Shared Cliques (k3-6) 56.25
Graphlets Similarity 0.703144
Paths Difference
Value glp1_on_allo glp1_on
Number Of Nodes in MetaPath 64 68
Specific Nodes in MetaPath 28 (43.75%) 32  (47.06%)
Shared Nodes in MetaPath 355 (99.72%) 355  (99.72%)
Number Of Links MetaPath 64 67
Specific Links in MetaPath 39 (60.94%) 42  (62.69%)
Shared Links in MetaPath 273 (67.24%) 273  (67.24%)
Number of Shortest Paths 78328 91639
Length Of Smallest Path 3 3
Average Path Length 11.8772 14.1911
Length of Longest Path 32 40
Minimum Path Strength 1.29 0.466078
Average Path Strength 8.52555 6.29122
Maximum Path Strength 32.99 16.0188
Minimum Path Correlation 0.7 0.700588
Average Path Correlation 0.952839 0.948589
Maximum Path Correlation 1 0.996471
Minimum % Of Corr. Nodes 5 2.7027
Average % Of Corr. Nodes 60.0305 50.3233
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 44.0712 44.0534
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

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