psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Orange: nodes, hubs and links specific of h1_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of h1_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	h1_on Int. Strength	h1_off Int. Strength	h1_on Hub1?	h1_off Hub1?	h1_on Hub2?	h1_off Hub2?	ConSurf1	ConSurf2
1	1x38	1x42	h1_on	3.07	0	No	No	No	No	4	7
2	1x46	2x54	h1_on	3.64	0	Yes	No	No	No	9	9
3	1x47	1x48	h1_on	3.68	0	No	No	No	No	6	6
4	1x47	1x51	h1_on	2.98	0	No	No	No	No	6	8
5	1x50	2x47	h1_on	2.98	0	No	No	No	No	9	9
6	1x53	7x54	h1_on	3.53	0	No	No	No	No	9	9
7	1x54	1x58	h1_on	9.72	0	No	No	No	No	8	6
8	1x59	1x60	h1_on	4.31	0	No	No	No	No	7	8
9	4x39	I1x51	h1_on	6.55	0	No	No	No	No	8	8
10	2x37	2x38	h1_on	3.17	0	No	No	Yes	No	9	9
11	2x38	2x39	h1_on	3.68	0	Yes	No	No	No	9	8
12	2x40	8x47	h1_on	5.45	0	No	No	No	No	9	9
13	2x43	7x54	h1_on	6.77	0	No	No	No	No	9	9
14	2x46	2x50	h1_on	5.43	0	Yes	No	Yes	Yes	9	9
15	2x46	3x43	h1_on	4.47	0	Yes	No	No	No	9	9
16	2x48	2x52	h1_on	3.07	0	No	No	No	No	6	8
17	2x49	4x50	h1_on	3.89	0	No	No	Yes	No	9	9
18	2x53	7x42	h1_on	3.79	0	No	No	Yes	Yes	9	9
19	2x59	E1x50	h1_on	8.14	0	Yes	No	Yes	Yes	8	9
20	2x60	3x28	h1_on	11.3	0	Yes	No	Yes	No	8	9
21	2x60	7x38	h1_on	7.08	0	Yes	No	Yes	Yes	8	8
22	2x63	3x28	h1_on	5.79	0	No	No	Yes	No	7	9
23	2x63	E2x50	h1_on	5.38	0	No	No	Yes	No	7	9
24	2x64	7x39	h1_on	3.42	0	No	No	Yes	Yes	8	9
25	E1x49	E2.E177	h1_on	6.75	0	No	No	No	No	2	3
26	3x24	E1x50	h1_on	3.42	0	No	No	Yes	Yes	7	9
27	3x24	E1x52	h1_on	9.69	0	No	No	No	No	7	9
28	3x22	E2.R175	h1_on	23.46	0	No	No	No	No	5	4
29	3x22	E2.D183	h1_on	3.57	0	No	No	No	No	5	7
30	3x25	3x29	h1_on	3.17	0	No	No	Yes	No	9	9
31	3x28	3x29	h1_on	5.69	0	Yes	No	Yes	No	9	9
32	3x29	E2x52	h1_on	4.42	0	Yes	No	No	No	9	9
33	3x32	3x36	h1_on	4.42	0	Yes	No	No	No	9	9
34	3x33	4x61	h1_on	3.63	0	Yes	No	No	No	9	9
35	3x33	E2.F184	h1_on	6.19	0	Yes	No	Yes	Yes	9	9
36	3x33	6x51	h1_on	2.98	0	Yes	No	Yes	Yes	9	9
37	3x37	Lig	h1_on	5.55	0	Yes	Yes	Yes	Yes	9	0
38	3x38	4x53	h1_on	3.42	0	No	No	Yes	No	9	9
39	3x40	6x48	h1_on	15.27	0	No	No	Yes	Yes	9	9
40	3x41	5x461	h1_on	7.25	0	No	No	Yes	No	8	9
41	3x42	3x45	h1_on	3.1	0	No	No	Yes	No	8	8
42	3x43	7x53	h1_on	7.57	0	No	No	Yes	No	9	9
43	3x44	5x50	h1_on	4.33	0	No	No	No	No	8	9
44	3x45	4x49	h1_on	3.25	0	Yes	No	No	No	8	7
45	3x46	3x50	h1_on	6.07	0	No	No	No	No	9	9
46	3x46	7x53	h1_on	8.21	0	No	No	Yes	No	9	9
47	3x47	5x57	h1_on	4.19	0	No	No	Yes	No	8	7
48	3x47	5x58	h1_on	14.79	0	No	No	Yes	Yes	8	9
49	3x49	3x53	h1_on	4.42	0	No	No	No	No	9	9
50	3x50	5x58	h1_on	3.09	0	No	No	Yes	Yes	9	9
51	3x52	I2x56	h1_on	3.09	0	No	No	Yes	No	8	8
52	3x55	3x56	h1_on	3.84	0	No	No	No	No	8	7
53	3x55	5x60	h1_on	6.78	0	No	No	No	No	8	5
54	I2x52	I2x57	h1_on	3.2	0	No	Yes	No	Yes	5	9
55	I2x53	I2x54	h1_on	5.86	0	No	Yes	No	No	9	8
56	I2x54	I2x56	h1_on	14.07	0	No	No	Yes	No	8	8
57	4x40	4x43	h1_on	3.2	0	No	No	No	No	6	6
58	4x50	4x53	h1_on	3.71	0	Yes	No	Yes	No	9	9
59	4x51	4x54	h1_on	3.22	0	No	No	No	No	5	5
60	4x57	E2.F184	h1_on	4.01	0	Yes	Yes	Yes	Yes	8	9
61	E2.T172	E2.W165	h1_on	3.64	0	No	No	No	Yes	4	9
62	E2.H167	E2.N166	h1_on	15.31	0	No	No	No	No	4	6
63	E2.F168	E2.F184	h1_on	7.5	0	Yes	No	Yes	Yes	6	9
64	5x36	E2.F168	h1_on	10.49	0	No	No	Yes	No	8	6
65	5x39	E2.F168	h1_on	5.36	0	Yes	Yes	Yes	No	9	6
66	E2.Q170	E2.Q171	h1_on	5.12	0	No	No	Yes	No	5	2
67	E2.Q171	E2.V174	h1_on	10.03	0	Yes	No	Yes	No	2	2
68	E2.Q171	E2.Y185	h1_on	6.76	0	Yes	No	No	No	2	7
69	E2.D186	E2.Q171	h1_on	14.36	0	No	No	Yes	No	3	2
70	E2.R176	E2.V174	h1_on	9.15	0	No	No	Yes	No	1	2
71	E2.V174	E2x51	h1_on	8.56	0	Yes	No	Yes	No	2	7
72	7x31	E2.D178	h1_on	3.9	0	No	No	No	No	4	3
73	7x31	E2.K179	h1_on	8.1	0	No	No	No	No	4	4
74	5x40	6x58	h1_on	4.36	0	No	No	No	No	9	6
75	5x44	6x56	h1_on	3.22	0	No	No	No	No	9	7
76	5x461	6x52	h1_on	6.04	0	Yes	No	Yes	No	9	9
77	5x47	6x44	h1_on	4.29	0	Yes	Yes	Yes	Yes	9	9
78	5x47	6x48	h1_on	3.01	0	Yes	Yes	Yes	Yes	9	9
79	5x48	6x53	h1_on	4.84	0	No	No	No	No	8	7
80	5x49	5x53	h1_on	4.15	0	No	No	No	No	7	6
81	5x51	6x44	h1_on	7.78	0	No	No	Yes	Yes	9	9
82	5x54	6x44	h1_on	8.71	0	Yes	Yes	Yes	Yes	9	9
83	5x62	6x34	h1_on	4	0	Yes	No	No	No	8	9
84	5x65	6x29	h1_on	3.92	0	No	No	Yes	No	9	8
85	5x66	5x68	h1_on	6.77	0	No	No	No	No	7	8
86	5x66	6x30	h1_on	3.49	0	No	No	No	No	7	8
87	5x67	6x29	h1_on	16.35	0	No	No	Yes	No	5	8
88	6x25	6x28	h1_on	4.12	0	No	No	No	No	5	7
89	6x25	6x29	h1_on	3.64	0	No	No	Yes	No	5	8
90	6x27	6x28	h1_on	4.21	0	No	No	No	No	3	7
91	6x29	6x30	h1_on	11.63	0	Yes	No	No	No	8	8
92	6x36	6x40	h1_on	5.49	0	No	No	No	No	9	9
93	6x38	6x41	h1_on	5.24	0	No	No	No	No	8	9
94	6x45	6x46	h1_on	5.71	0	No	No	No	No	8	5
95	6x45	6x49	h1_on	4.42	0	No	No	No	No	8	8
96	6x48	6x52	h1_on	4.01	0	Yes	Yes	Yes	No	9	9
97	6x51	6x52	h1_on	6.19	0	Yes	Yes	Yes	No	9	9
98	6x52	6x55	h1_on	8.57	0	Yes	No	No	No	9	8
99	6x58	7x30	h1_on	7.08	0	No	No	No	No	6	6
100	6x61	E3.N443	h1_on	4.72	0	No	No	No	No	7	4
101	7x30	7x31	h1_on	10.52	0	No	No	No	No	6	4
102	7x38	7x39	h1_on	3.52	0	Yes	Yes	Yes	Yes	8	9
103	7x42	Lig	h1_on	4.41	0	Yes	Yes	Yes	Yes	9	0
104	7x52	7x53	h1_on	3.63	0	No	No	Yes	No	9	9
105	8x47	8x48	h1_on	9.2	0	No	No	No	No	9	5
106	8x48	8x50	h1_on	4.66	0	No	No	Yes	No	5	9
107	8x53	8x54	h1_on	5.19	0	No	No	Yes	Yes	8	9
108	7x54	8x50	h1_on	2.89	0	No	No	Yes	No	9	9
109	1x52	CT.I485	h1_on	2.85	0	No	No	No	No	9	8
110	2x59	2x62	h1_on	2.83	0	Yes	No	No	No	8	6
111	3x21	E1x50	h1_on	2.81	0	No	No	Yes	Yes	8	9
112	5x62	6x33	h1_on	2.67	0	Yes	No	No	No	8	9
113	6x26	6x27	h1_on	2.63	0	No	No	No	No	5	3
114	5x39	5x42	h1_on	2.49	0	Yes	Yes	No	No	9	7
115	7x55	8x54	h1_on	2.44	0	No	No	Yes	Yes	8	9
116	2x52	4x50	h1_on	2.35	0	No	No	Yes	No	8	9
117	E2.F168	E2.Q170	h1_on	2.34	0	Yes	No	No	No	6	5
118	5x62	6x37	h1_on	2.34	0	Yes	No	No	No	8	9
119	3x22	E2x51	h1_on	2.33	0	No	No	Yes	No	5	7
120	1x40	1x43	h1_on	1.72	0	No	No	No	No	7	9
121	4x47	4x48	h1_on	1.71	0	No	No	No	No	7	5
122	6x57	6x61	h1_on	1.71	0	No	No	No	No	8	7
123	2x55	2x551	h1_on	1.7	0	No	No	No	No	7	6
124	4x63	E2.N166	h1_on	1.7	0	No	No	No	No	7	6
125	2x57	2x58	h1_on	1.68	0	Yes	Yes	No	No	9	9
126	2x58	2x59	h1_on	1.68	0	No	No	Yes	No	9	8
127	I2x50	I2x51	h1_on	1.64	0	No	No	No	No	9	8
128	1x36	1x40	h1_on	1.62	0	No	No	No	No	7	7
129	1x56	8x57	h1_on	1.62	0	No	No	No	No	9	8
130	3x30	3x34	h1_on	1.62	0	No	No	No	No	9	9
131	3x34	4x53	h1_on	1.62	0	No	No	Yes	No	9	9
132	E2.S173	E2.V174	h1_on	1.62	0	No	No	Yes	No	3	2
133	6x43	7x52	h1_on	1.62	0	No	No	No	No	8	9
134	5x40	6x59	h1_on	1.61	0	No	No	No	No	9	8
135	1x43	1x44	h1_on	1.59	0	No	No	No	No	9	7
136	5x37	5x41	h1_on	1.59	0	No	No	No	No	8	8
137	6x47	7x48	h1_on	1.59	0	No	No	No	No	9	8
138	2x51	2x55	h1_on	1.58	0	No	No	No	No	8	7
139	7x30	E3.C444	h1_on	1.57	0	No	No	No	No	6	5
140	E1.S91	E1x49	h1_on	1.53	0	No	No	No	No	3	2
141	1x42	1x46	h1_on	1.52	0	No	No	Yes	No	7	9
142	2x38	4x39	h1_on	1.52	0	Yes	No	No	No	9	8
143	2x41	4x43	h1_on	1.5	0	No	No	No	No	8	6
144	E1x51	E1x52	h1_on	1.5	0	No	No	No	No	5	9
145	1x54	2x44	h1_on	1.49	0	No	No	No	No	8	8
146	1x35	2x64	h1_on	1.38	0	No	No	No	No	9	8
147	1x52	8x58	h1_on	1.38	0	No	No	No	No	9	8
148	E2.D186	E3.K442	h1_on	1.38	0	No	No	No	No	3	3
149	8x56	8x57	h1_on	1.25	0	No	No	No	No	6	8
150	4x51	4x55	h1_on	1.22	0	No	No	No	No	5	5
151	1x39	7x39	Shared	11.39	18.6033	No	No	Yes	Yes	8	9
152	1x43	2x57	Shared	4.86	4.32	No	No	Yes	Yes	9	9
153	1x45	1x49	Shared	4.47	2.98	No	No	No	No	4	9
154	1x46	2x57	Shared	9.03	4.52	Yes	No	Yes	Yes	9	9
155	1x46	7x47	Shared	10.99	10.4667	Yes	No	No	No	9	9
156	1x49	7x50	Shared	3.28	4.37667	No	No	No	No	9	9
157	1x50	2x50	Shared	6.73	6.73333	No	No	Yes	Yes	9	9
158	1x50	7x50	Shared	13.03	10.86	No	No	No	No	9	9
159	1x52	8x54	Shared	4.87	6.49667	No	No	Yes	Yes	9	9
160	1x53	2x47	Shared	6.46	5.92333	No	No	No	No	9	9
161	1x55	1x59	Shared	5.09	2.97	No	No	No	No	5	7
162	1x55	8x57	Shared	10.88	0.806667	No	No	No	No	5	8
163	2x40	I1x50	Shared	5.49	6.86667	No	No	No	No	9	9
164	8x50	I1x50	Shared	7.31	5.68	Yes	No	No	No	9	9
165	2x37	2x40	Shared	7.31	9.26	No	No	No	No	9	9
166	2x38	I2x57	Shared	5.23	10.9	Yes	No	No	Yes	9	9
167	2x42	3x45	Shared	4.84	6.44667	Yes	Yes	Yes	No	8	8
168	2x42	3x46	Shared	5.86	7.42667	Yes	Yes	No	No	8	9
169	2x42	3x49	Shared	13.79	12.64	Yes	Yes	No	No	8	9
170	2x42	4x45	Shared	6.24	3.75	Yes	Yes	No	No	8	8
171	2x42	4x46	Shared	4.84	4.03333	Yes	Yes	No	No	8	9
172	2x45	3x42	Shared	4.89	6.52	No	No	No	No	9	8
173	2x45	4x46	Shared	9.29	4.64333	No	No	No	No	9	9
174	2x45	4x50	Shared	4.94	5.35333	No	No	Yes	No	9	9
175	2x46	7x49	Shared	10.98	4.58	Yes	No	No	No	9	9
176	2x46	7x53	Shared	3.52	4.69	Yes	No	Yes	No	9	9
177	2x50	3x39	Shared	5.89	4.41667	Yes	Yes	No	No	9	9
178	2x50	7x46	Shared	10.31	9.32333	Yes	Yes	No	No	9	9
179	2x50	7x49	Shared	9.42	4.04	Yes	Yes	No	No	9	9
180	2x52	3x35	Shared	3.25	3.25	No	No	No	No	8	8
181	2x53	2x56	Shared	3.21	3.74333	No	No	No	Yes	9	9
182	2x53	7x46	Shared	8.08	4.30667	No	No	No	No	9	9
183	2x54	2x57	Shared	6.99	4.65667	No	No	Yes	Yes	9	9
184	2x551	3x31	Shared	9.13	4.56333	No	No	No	No	6	8
185	2x56	3x32	Shared	13.15	7.3	No	Yes	Yes	No	9	9
186	2x56	7x42	Shared	5.05	6.73	No	Yes	Yes	Yes	9	9
187	2x57	7x39	Shared	4.65	5.04	Yes	Yes	Yes	Yes	9	9
188	2x57	7x42	Shared	3.59	6.78333	Yes	Yes	Yes	Yes	9	9
189	2x59	3x28	Shared	16.29	8.53	Yes	No	Yes	No	8	9
190	2x60	7x39	Shared	3.39	8.66333	Yes	No	Yes	Yes	8	9
191	2x60	7x42	Shared	11.63	3.87667	Yes	No	Yes	Yes	8	9
192	2x61	7x39	Shared	4.7	3.52333	No	No	Yes	Yes	8	9
193	2x63	E1x50	Shared	12.54	11.2533	No	No	Yes	Yes	7	9
194	2x66	E1x51	Shared	6.13	1.02333	No	Yes	No	No	5	5
195	E1x50	E1x52	Shared	12.53	6.07333	Yes	Yes	No	No	9	9
196	3x25	E1x50	Shared	7.84	7.40333	No	No	Yes	Yes	9	9
197	3x28	E1x50	Shared	8.43	3.43667	Yes	No	Yes	Yes	9	9
198	E1x50	E2x50	Shared	7.84	6.53	Yes	Yes	Yes	No	9	9
199	3x25	E2x50	Shared	7.28	7.28	No	No	Yes	No	9	9
200	3x26	4x62	Shared	5.54	2.76667	No	No	No	No	8	7
201	3x27	3x31	Shared	9.95	9.95333	No	No	No	No	8	8
202	3x29	E2x50	Shared	4.76	3.17333	Yes	No	Yes	No	9	9
203	3x30	4x58	Shared	3.23	6.46333	No	No	No	No	9	5
204	3x32	7x42	Shared	13.79	5.36667	Yes	No	Yes	Yes	9	9
205	3x32	Lig	Shared	10.22	11.5733	Yes	No	Yes	Yes	9	0
206	3x33	4x57	Shared	15.43	8.36	Yes	No	Yes	Yes	9	8
207	3x33	Lig	Shared	19.86	15.9	Yes	No	Yes	Yes	9	0
208	3x36	6x48	Shared	4.94	4.12	No	No	Yes	Yes	9	9
209	3x36	Lig	Shared	7.07	9.95	No	No	Yes	Yes	9	0
210	3x37	3x41	Shared	6.49	4.75667	Yes	Yes	No	No	9	8
211	3x37	4x53	Shared	3.2	5.33333	Yes	Yes	Yes	No	9	9
212	3x37	4x57	Shared	9.7	7.28	Yes	Yes	Yes	Yes	9	8
213	3x37	5x461	Shared	10.24	7.31	Yes	Yes	Yes	No	9	9
214	3x38	4x50	Shared	9.08	8.21333	No	No	Yes	No	9	9
215	3x40	6x44	Shared	3.77	7.95333	No	No	Yes	Yes	9	9
216	3x43	5x54	Shared	4.56	3.04	No	No	Yes	Yes	9	9
217	3x44	5x53	Shared	4.87	6.09	No	No	No	No	8	6
218	3x44	5x54	Shared	3.73	6.63333	No	No	Yes	Yes	8	9
219	3x45	4x45	Shared	4.56	8.10667	Yes	No	No	No	8	8
220	3x47	5x54	Shared	6.48	4.32	No	No	Yes	Yes	8	9
221	3x48	5x57	Shared	8.79	5.86333	No	No	Yes	No	6	7
222	3x51	3x55	Shared	14.65	3.00667	Yes	Yes	No	No	9	8
223	3x51	5x57	Shared	12.38	9.62667	Yes	Yes	Yes	No	9	7
224	3x51	5x60	Shared	7.17	11.1467	Yes	Yes	No	No	9	5
225	3x51	5x61	Shared	3.63	4.03	Yes	Yes	No	No	9	9
226	3x52	I2x52	Shared	17.06	6.39667	No	No	No	Yes	8	5
227	3x54	5x61	Shared	4.61	3.07333	No	No	No	No	9	9
228	3x56	I2x50	Shared	7.9	2.10667	No	No	No	No	7	9
229	I2x52	I2x56	Shared	11.32	4.8	No	Yes	Yes	No	5	8
230	4x41	I2x56	Shared	12.35	9.94667	No	No	Yes	No	9	8
231	4x38	4x40	Shared	4.71	3.14	No	No	No	No	9	6
232	4x57	5x43	Shared	7.28	7.68333	Yes	Yes	No	No	8	8
233	4x59	4x60	Shared	3.39	3.39	No	No	No	No	8	9
234	4x60	5x39	Shared	4.33	1.44333	No	No	Yes	Yes	9	9
235	E2.N166	E2.W165	Shared	6.78	3.76667	No	No	No	Yes	6	9
236	E2.R176	E2x51	Shared	3.49	5.42667	No	No	Yes	No	1	7
237	E2.Y185	E2x51	Shared	7.86	13.47	No	No	Yes	No	7	7
238	E2.F184	E2x52	Shared	5.19	14.6967	Yes	Yes	No	No	9	9
239	E2.D186	E2.Y185	Shared	13.79	6.13333	No	No	No	No	3	7
240	5x37	6x59	Shared	3.36	1.12	No	No	No	No	8	8
241	5x39	5x43	Shared	7.78	3.89333	Yes	Yes	No	No	9	8
242	5x40	6x55	Shared	17.37	7.03333	No	No	No	No	9	8
243	5x461	Lig	Shared	7.75	8.90333	Yes	No	Yes	Yes	9	0
244	5x47	5x48	Shared	14.44	5.84667	Yes	Yes	No	No	9	8
245	5x47	5x51	Shared	11.67	4.32	Yes	Yes	No	No	9	9
246	5x47	6x52	Shared	23.58	27.8667	Yes	Yes	Yes	No	9	9
247	5x48	6x56	Shared	4.79	2.79333	No	No	No	No	8	7
248	5x49	5x50	Shared	3.28	2.18667	No	No	No	No	7	9
249	5x55	6x41	Shared	4.24	1.88333	No	No	No	No	7	9
250	5x56	5x57	Shared	6.01	5.68	No	No	Yes	No	4	7
251	5x58	6x37	Shared	3.52	3.51667	Yes	Yes	No	No	9	9
252	5x62	5x66	Shared	3.09	8.72667	Yes	No	No	No	8	7
253	5x68	6x30	Shared	12.31	2.97333	No	No	No	No	8	8
254	6x36	7x56	Shared	9.16	5.59333	No	No	No	No	9	9
255	6x39	7x52	Shared	10.05	5.02667	No	No	No	No	7	9
256	6x40	7x53	Shared	4.84	3.63	No	No	Yes	No	9	9
257	6x47	7x45	Shared	9.45	7.87333	No	No	No	Yes	9	9
258	6x48	7x41	Shared	8.44	11.26	Yes	Yes	No	No	9	9
259	6x48	7x45	Shared	9.04	3.76667	Yes	Yes	No	Yes	9	9
260	6x49	6x50	Shared	3.39	5.08	No	No	No	No	8	9
261	6x49	6x53	Shared	2.94	1.96333	No	No	No	No	8	7
262	6x50	7x40	Shared	3.28	3.28333	No	No	No	No	9	9
263	6x51	7x37	Shared	4.99	6.24333	Yes	Yes	No	No	9	9
264	6x51	7x38	Shared	4.84	5.24	Yes	Yes	Yes	Yes	9	8
265	6x51	Lig	Shared	24.27	11.23	Yes	Yes	Yes	Yes	9	0
266	6x52	Lig	Shared	9.17	16.8467	Yes	No	Yes	Yes	9	0
267	6x54	6x58	Shared	3.77	2.09333	No	No	No	No	7	6
268	6x54	7x33	Shared	8.53	5.27667	No	No	No	No	7	4
269	6x61	E3.C444	Shared	7.28	7.28	No	No	No	No	7	5
270	7x34	7x38	Shared	6.63	4.86	No	Yes	Yes	Yes	7	8
271	7x36	7x40	Shared	9.74	4.06	No	No	No	No	5	9
272	7x38	7x42	Shared	9.67	5.24	Yes	Yes	Yes	Yes	8	9
273	7x39	7x42	Shared	3.86	8.68333	Yes	Yes	Yes	Yes	9	9
274	7x45	7x49	Shared	12.26	7.72	No	Yes	No	No	9	9
275	8x50	8x54	Shared	5.36	4.64667	Yes	No	Yes	Yes	9	9
276	5x42	5x46	Shared	2.92	0.486667	No	No	No	No	7	5
277	7x43	7x48	Shared	2.85	2.85	No	No	No	No	6	8
278	2x64	7x35	Shared	2.83	7.54	No	No	No	No	8	6
279	1x51	2x51	Shared	2.77	4.15	No	No	No	No	8	8
280	2x42	4x42	Shared	2.67	4	Yes	Yes	No	No	8	9
281	5x58	6x41	Shared	2.39	5.58667	Yes	Yes	No	No	9	9
282	3x21	3x23	Shared	2.03	2.03	No	No	No	No	8	5
283	1x47	2x54	Shared	1.84	1.84	No	No	No	No	6	9
284	6x57	E3.C444	Shared	1.71	1.71	No	No	No	No	8	5
285	3x54	5x64	Shared	1.7	1.7	No	No	No	No	9	6
286	1x34	NT.M28	Shared	1.68	1.68	No	No	No	No	3	5
287	1x56	8x53	Shared	1.68	2.24	No	No	No	No	9	8
288	2x44	2x48	Shared	1.6	1.6	No	No	No	No	8	6
289	2x41	4x42	Shared	1.58	1.05333	No	No	No	No	8	9
290	5x41	5x45	Shared	1.54	2.04667	No	No	No	No	8	7
291	4x48	4x51	Shared	1.51	1.51	No	No	No	No	5	5
292	1x36	2x65	Shared	1.49	2.98	No	No	No	No	7	6
293	1x54	2x48	Shared	1.49	3.47667	No	No	No	No	8	6
294	4x58	4x62	Shared	1.49	2.48333	No	No	No	No	5	7
295	6x59	6x60	Shared	1.39	1.38667	No	No	No	No	8	7
296	1x35	1x39	Shared	1.38	1.84333	No	No	No	No	9	8
297	3x34	4x54	Shared	1.31	10.05	No	No	No	No	9	5
298	E2.D183	E2.W165	Shared	1.12	7.81667	No	No	No	Yes	7	9
299	5x38	5x39	Shared	1	6.01333	No	No	Yes	Yes	5	9
300	1x40	2x61	h1_off	0	4.13	No	No	No	No	7	8
301	1x43	2x58	h1_off	0	4.39667	No	No	No	No	9	9
302	1x53	8x54	h1_off	0	3.93	No	No	Yes	Yes	9	9
303	1x54	2x47	h1_off	0	5.00667	No	No	No	No	8	9
304	1x57	2x44	h1_off	0	4.81	No	No	No	No	8	8
305	1x60	I1x49	h1_off	0	4.05	No	No	No	No	8	7
306	1x60	8x53	h1_off	0	5.64333	No	No	No	No	8	8
307	2x40	2x43	h1_off	0	5.19	No	No	No	No	9	9
308	2x43	7x53	h1_off	0	9.27	No	No	Yes	No	9	9
309	2x46	3x42	h1_off	0	4.00333	Yes	No	No	No	9	8
310	2x56	3x28	h1_off	0	6.13	No	Yes	Yes	No	9	9
311	2x59	3x24	h1_off	0	3.76667	Yes	No	No	No	8	7
312	E1x49	E2.D178	h1_off	0	4.61	No	No	No	No	2	3
313	3x22	3x26	h1_off	0	10.1233	No	No	No	No	5	8
314	3x22	E2.V174	h1_off	0	4.36	No	No	Yes	No	5	2
315	3x33	E2x52	h1_off	0	4.57667	Yes	No	No	No	9	9
316	3x40	5x50	h1_off	0	6.20667	No	No	No	No	9	9
317	3x40	Lig	h1_off	0	4.59	No	No	Yes	Yes	9	0
318	3x41	4x52	h1_off	0	4.47	No	No	No	No	8	7
319	3x43	6x44	h1_off	0	3.93333	No	No	Yes	Yes	9	9
320	3x44	3x48	h1_off	0	10.0467	No	No	No	No	8	6
321	3x50	6x33	h1_off	0	4.61	No	No	No	No	9	9
322	3x52	I2x53	h1_off	0	6.17333	No	No	No	Yes	8	9
323	3x53	I2x57	h1_off	0	3.95667	No	No	No	Yes	9	9
324	4x57	5x461	h1_off	0	9.04	Yes	Yes	Yes	No	8	9
325	4x57	Lig	h1_off	0	4.65667	Yes	Yes	Yes	Yes	8	0
326	E2.M169	E2.W165	h1_off	0	5.43	No	No	No	Yes	5	9
327	E2.Q171	E2.W165	h1_off	0	4.01667	Yes	No	No	Yes	2	9
328	E2.F184	E2.W165	h1_off	0	5.01333	Yes	Yes	No	Yes	9	9
329	5x39	E2.W165	h1_off	0	5.34667	Yes	Yes	No	Yes	9	9
330	5x39	E2.F184	h1_off	0	12.5033	Yes	Yes	Yes	Yes	9	9
331	5x43	Lig	h1_off	0	3.62667	No	No	Yes	Yes	8	0
332	5x45	5x48	h1_off	0	3.62667	No	No	No	No	7	8
333	5x51	6x45	h1_off	0	4.05333	No	No	No	No	9	8
334	5x54	6x41	h1_off	0	6.26	Yes	Yes	No	No	9	9
335	5x56	5x60	h1_off	0	5.02667	No	No	No	No	4	5
336	5x58	6x38	h1_off	0	4.82667	Yes	Yes	No	No	9	8
337	6x36	8x47	h1_off	0	4.84	No	No	No	No	9	9
338	6x39	7x56	h1_off	0	5.58667	No	No	No	No	7	9
339	6x44	6x48	h1_off	0	6.01333	Yes	Yes	Yes	Yes	9	9
340	6x44	7x45	h1_off	0	7.24667	Yes	Yes	No	Yes	9	9
341	6x48	6x51	h1_off	0	7.39667	Yes	Yes	Yes	Yes	9	9
342	6x48	Lig	h1_off	0	12.0133	Yes	Yes	Yes	Yes	9	0
343	6x51	6x55	h1_off	0	10.66	Yes	Yes	No	No	9	8
344	6x51	7x34	h1_off	0	4.71667	Yes	Yes	No	Yes	9	7
345	6x54	7x34	h1_off	0	10.18	No	No	No	Yes	7	7
346	6x55	Lig	h1_off	0	6.30667	No	No	Yes	Yes	8	0
347	7x38	Lig	h1_off	0	4.99667	Yes	Yes	Yes	Yes	8	0
348	7x54	8x54	h1_off	0	7.70333	No	No	Yes	Yes	9	9
349	8x47	8x50	h1_off	0	8.05333	No	No	Yes	No	9	9
350	3x49	I2x57	h1_off	0	6.35333	No	No	No	Yes	9	9
351	3x50	6x37	h1_off	0	4.04667	No	No	No	No	9	9
352	3x52	I2x57	h1_off	0	3.91	No	No	No	Yes	8	9
353	3x56	I2x52	h1_off	0	7.01	No	No	No	Yes	7	5
354	5x36	5x38	h1_off	0	4.49667	No	No	No	No	8	5
355	5x68	6x31	h1_off	0	4.51333	No	No	No	Yes	8	7
356	6x25	6x31	h1_off	0	3.64333	No	No	No	Yes	5	7
357	6x27	6x30	h1_off	0	3.61	No	No	No	No	3	8
358	7x31	7x34	h1_off	0	4.51333	No	No	No	Yes	4	7
359	3x49	I2x53	h1_off	0	3.83	No	No	No	Yes	9	9
360	I2x53	I2x57	h1_off	0	3.77333	No	Yes	No	Yes	9	9
361	E2.D178	E2.R176	h1_off	0	3.57333	No	No	No	No	3	1
362	5x69	6x30	h1_off	0	3.53667	No	No	No	No	5	8
363	7x35	7x39	h1_off	0	3.49	No	No	Yes	Yes	6	9
364	1x58	2x44	h1_off	0	3.48667	No	No	No	No	6	8
365	7x30	7x32	h1_off	0	3.4	No	No	No	No	6	2
366	I1x48	I1x51	h1_off	0	3.38333	No	No	No	No	8	8
367	2x39	2x42	h1_off	0	3.38333	No	No	Yes	Yes	8	8
368	4x61	E2.F184	h1_off	0	3.35	No	No	Yes	Yes	9	9
369	5x47	6x49	h1_off	0	3.34667	Yes	Yes	No	No	9	8
370	4x38	I2x56	h1_off	0	3.33	No	No	Yes	No	9	8
371	E2.K179	E2.R176	h1_off	0	3.30333	No	No	No	No	4	1
372	6x35	7x56	h1_off	0	3.23333	No	No	No	No	7	9
373	6x43	7x45	h1_off	0	3.12667	No	No	No	Yes	8	9
374	3x30	4x61	h1_off	0	3.09667	No	No	No	No	9	9
375	NT.P25	NT.S24	h1_off	0	2.96667	No	No	No	No	0	0
376	5x46	5x49	h1_off	0	2.85333	No	No	No	No	5	7
377	2x53	3x35	h1_off	0	2.82667	No	No	No	No	9	8
378	2x63	E2.K179	h1_off	0	2.78667	No	No	No	No	7	4
379	5x44	6x52	h1_off	0	2.77	No	No	Yes	No	9	9
380	1x50	2x51	h1_off	0	2.75	No	No	No	No	9	8
381	E1x50	E2.R175	h1_off	0	2.66667	Yes	Yes	No	No	9	4
382	6x39	7x55	h1_off	0	2.43667	No	No	No	No	7	8
383	6x28	6x31	h1_off	0	2.41	No	No	No	Yes	7	7
384	3x22	3x23	h1_off	0	2.4	No	No	No	No	5	5
385	2x41	4x39	h1_off	0	2.35	No	No	No	No	8	8
386	1x56	8x54	h1_off	0	2.31	No	No	Yes	Yes	9	9
387	8x49	I1x50	h1_off	0	2.28667	No	No	No	No	9	9
388	2x49	3x39	h1_off	0	2.28	No	No	No	No	9	9
389	8x48	8x51	h1_off	0	2.25	No	No	No	No	5	8
390	6x32	8x48	h1_off	0	2.25	No	No	No	No	9	5
391	5x65	6x31	h1_off	0	2.18	No	No	No	Yes	9	7
392	7x32	7x33	h1_off	0	2.14333	No	No	No	No	2	4
393	4x63	E2.H167	h1_off	0	2.12	No	No	No	No	7	4
394	NT.A23	NT.L27	h1_off	0	2.1	No	No	No	No	0	0
395	4x43	4x46	h1_off	0	2.06333	No	No	No	No	6	9
396	I2x52	I2x54	h1_off	0	2.02333	No	Yes	No	No	5	8
397	5x67	5x68	h1_off	0	1.94667	No	No	No	No	5	8
398	2x62	2x66	h1_off	0	1.88333	No	No	No	Yes	6	5
399	3x41	4x49	h1_off	0	1.85	No	No	No	No	8	7
400	1x49	7x51	h1_off	0	1.84333	No	No	No	No	9	7
401	2x62	E1x52	h1_off	0	1.84333	No	No	No	No	6	9
402	1x47	2x55	h1_off	0	1.7	No	No	No	No	6	7
403	5x41	6x59	h1_off	0	1.7	No	No	No	No	8	8
404	5x65	6x34	h1_off	0	1.69667	No	No	No	No	9	9
405	4x50	4x54	h1_off	0	1.67	Yes	No	No	No	9	5
406	E2.F168	E2.M169	h1_off	0	1.66	Yes	No	No	No	6	5
407	1x36	1x37	h1_off	0	1.60333	No	No	No	No	7	4
408	7x33	E3.C445	h1_off	0	1.58667	No	No	No	No	4	5
409	2x52	2x551	h1_off	0	1.53667	No	No	No	No	8	6
410	4x43	4x47	h1_off	0	1.5	No	No	No	No	6	7
411	1x35	1x38	h1_off	0	1.49	No	No	No	No	9	4
412	E1.S91	E2.E177	h1_off	0	1.43667	No	No	No	No	3	3
413	2x65	2x66	h1_off	0	1.41333	No	No	No	Yes	6	5
414	4x52	4x55	h1_off	0	1.38333	No	No	No	No	7	5
415	7x48	7x51	h1_off	0	1.38333	No	No	No	No	8	7
416	3x50	6x34	h1_off	0	1.38333	No	No	No	No	9	9
417	5x64	5x67	h1_off	0	1.38333	No	No	No	No	6	5
418	4x41	I2x55	h1_off	0	1.23667	No	No	No	No	9	5
419	1x42	7x39	h1_off	0	1.17333	No	No	Yes	Yes	7	9
420	I2x51	I2x53	h1_off	0	1.17333	No	No	No	Yes	8	9
421	1x48	1x51	h1_off	0	1.14	No	No	No	No	6	8
422	7x54	8x51	h1_off	0	1.11333	No	No	No	No	9	8
423	6x58	6x61	h1_off	0	1.09	No	No	No	No	6	7
424	1x41	1x45	h1_off	0	1.06	No	No	No	No	5	4
425	5x38	E2.H167	h1_off	0	1.05667	No	No	No	No	5	4
426	1x36	NT.M28	h1_off	0	1.01333	No	No	No	No	7	5
427	2x66	NT.T21	h1_off	0	1.00333	No	Yes	No	No	5	0
428	5x51	5x52	h1_off	0	0.98	No	No	No	No	9	5
429	8x51	8x55	h1_off	0	0.956667	No	No	No	No	8	8
430	E1x51	E2.E177	h1_off	0	0.956667	No	No	No	No	5	3
431	2x64	NT.L27	h1_off	0	0.923333	No	No	No	No	8	0
432	1x35	NT.L27	h1_off	0	0.923333	No	No	No	No	9	0
433	8x48	8x52	h1_off	0	0.9	No	No	No	No	5	7
434	8x58	8x59	h1_off	0	0.856667	No	No	No	No	8	6
435	6x29	6x32	h1_off	0	0.826667	Yes	No	No	No	8	9
436	5x58	5x62	h1_off	0	0.663333	Yes	Yes	Yes	No	9	8
437	1x59	8x53	h1_off	0	0.533333	No	No	No	No	7	8
438	NT.M22	NT.T20	h1_off	0	0.503333	No	No	No	No	0	0
439	5x37	E3.K442	h1_off	0	0.5	No	No	No	No	8	3
440	1x41	1x44	h1_off	0	0.49	No	No	No	No	5	7
441	NT.Q26	NT.S24	h1_off	0	0.48	No	No	No	No	0	0
442	6x58	E3.N443	h1_off	0	0.473333	No	No	No	No	6	4
443	5x63	5x67	h1_off	0	0.413333	No	No	No	No	6	5
444	8x52	8x56	h1_off	0	0.413333	No	No	No	No	7	6
445	8x55	8x56	h1_off	0	0.413333	No	No	No	No	8	6

Orange: nodes, hubs and links specific of h1_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of h1_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	h1_on Avg Int. Strength	h1_off Avg Int. Strength	h1_on Num Of Links	h1_off Num Of Links	ConSurf
1	1x46	h1_on	6.295	7.49333	4	2	9
2	2x38	h1_on	3.4	10.9	4	1	9
3	2x46	h1_on	6.1	4.42444	4	3	9
4	2x59	h1_on	7.235	6.14833	4	2	8
5	2x60	h1_on	8.35	6.27	4	2	8
6	3x28	h1_on	9.5	6.03222	5	3	9
7	3x29	h1_on	4.51	3.17333	4	1	9
8	3x32	h1_on	10.395	8.08	4	3	9
9	3x33	h1_on	9.618	9.61222	5	3	9
10	3x45	h1_on	3.9375	7.27667	4	2	8
11	I2x56	h1_on	10.2075	6.02556	4	3	8
12	4x50	h1_on	4.794	5.07889	5	3	9
13	4x53	h1_on	2.9875	5.33333	4	1	9
14	E2.F168	h1_on	6.4225	1.66	4	1	6
15	E2.Q171	h1_on	9.0675	4.01667	4	1	2
16	E2.V174	h1_on	7.34	4.36	4	1	2
17	E2x50	h1_on	6.315	5.66111	4	3	9
18	E2x51	h1_on	5.56	9.44833	4	2	7
19	5x461	h1_on	7.82	8.41778	4	3	9
20	5x57	h1_on	7.8425	7.05667	4	3	7
21	5x62	h1_on	3.025	4.695	4	2	8
22	6x29	h1_on	8.885	0.826667	4	1	8
23	6x52	h1_on	9.59333	15.8278	6	3	9
24	7x53	h1_on	5.554	5.86333	5	3	9
25	8x50	h1_on	5.055	6.12667	4	3	9
26	2x42	Shared	6.37333	5.95429	6	7	8
27	2x50	Shared	7.556	6.12833	5	4	9
28	2x57	Shared	5.13333	5.064	6	5	9
29	E1x50	Shared	7.94375	6.22722	8	6	9
30	3x37	Shared	7.036	6.17	5	4	9
31	3x51	Shared	9.4575	6.9525	4	4	9
32	4x57	Shared	9.105	7.404	4	5	8
33	E2.F184	Shared	5.7225	8.89083	4	4	9
34	5x39	Shared	4.192	5.84	5	5	9
35	5x47	Shared	11.398	10.345	5	4	9
36	5x54	Shared	5.87	5.06333	4	4	9
37	5x58	Shared	5.9475	3.64833	4	4	9
38	6x44	Shared	6.1375	6.28667	4	4	9
39	6x48	Shared	7.45167	7.42833	6	6	9
40	6x51	Shared	8.654	7.58111	5	6	9
41	7x38	Shared	6.348	5.08417	5	4	8
42	7x39	Shared	4.99	7.02524	7	7	9
43	7x42	Shared	6.97375	6.11333	8	6	9
44	8x54	Shared	4.465	5.01733	4	5	9
45	Lig	Shared	11.0375	9.21611	8	12	0
46	2x56	h1_off	7.13667	5.97583	3	4	9
47	2x66	h1_off	6.13	1.33083	1	4	5
48	I2x52	h1_off	10.5267	5.0575	3	4	5
49	I2x53	h1_off	5.86	3.7375	1	4	9
50	I2x57	h1_off	4.215	5.77867	2	5	9
51	E2.W165	h1_off	3.84667	5.23167	3	6	9
52	6x31	h1_off	0	3.18667	0	4	7
53	7x34	h1_off	6.63	6.0675	1	4	7
54	7x45	h1_off	10.25	5.94667	3	5	9

Orange: nodes, hubs and links specific of h1_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of h1_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	h1_on Recurrence	h1_off Recurrence	h1_on Hub1?	h1_off Hub1?	h1_on Hub2?	h1_off Hub2?	ConSurf1	ConSurf2
1	1x43	2x57	h1_on	11.3952	6.84118	No	No	Yes	Yes	9	9
2	2x53	7x42	h1_on	51.7205	0	No	No	Yes	Yes	9	9
3	1x47	2x54	h1_on	18.3447	6.84118	No	No	No	No	6	9
4	1x47	1x51	h1_on	13.8466	0	No	No	No	No	6	8
5	1x50	2x47	h1_on	67.9061	0	No	No	No	No	9	9
6	1x53	2x47	h1_on	66.0169	9.47206	No	No	No	No	9	9
7	1x53	7x54	h1_on	64.1128	0	No	No	No	No	9	9
8	7x54	8x50	h1_on	60.5218	0	No	No	Yes	No	9	9
9	7x42	Lig	h1_on	84.594	0	Yes	Yes	Yes	Yes	9	0
10	3x37	Lig	h1_on	45.9705	0	Yes	Yes	Yes	Yes	9	0
11	3x37	4x53	h1_on	56.1511	2.94765	Yes	Yes	Yes	No	9	9
12	4x50	4x53	h1_on	35.8348	0	Yes	No	Yes	No	9	9
13	2x52	4x50	h1_on	15.9157	0	No	No	Yes	No	8	9
14	2x48	2x52	h1_on	10.593	0	No	No	No	No	6	8
15	8x53	8x54	h1_on	15.9982	0	No	No	Yes	Yes	8	9
16	1x56	8x53	h1_on	13.7567	9.1421	No	No	No	No	9	8
17	1x56	8x57	h1_on	11.5001	0	No	No	No	No	9	8
18	2x37	2x40	h1_on	26.1789	1.59701	No	No	No	No	9	9
19	2x37	2x38	h1_on	24.0123	0	No	No	Yes	No	9	9
20	2x38	I2x57	h1_on	15.181	1.22305	Yes	No	No	Yes	9	9
21	2x46	2x50	h1_on	37.739	0	Yes	No	Yes	Yes	9	9
22	3x46	7x53	h1_on	27.2059	0	No	No	Yes	No	9	9
23	2x42	3x46	h1_on	25.7516	1.59701	Yes	Yes	No	No	8	9
24	2x45	4x50	h1_on	27.3559	6.34844	No	No	Yes	No	9	9
25	2x46	3x43	h1_on	14.6863	0	Yes	No	No	No	9	9
26	1x51	2x51	h1_on	11.5751	2.59129	No	No	No	No	8	8
27	2x60	3x28	h1_on	35.7448	0	Yes	No	Yes	No	8	9
28	2x60	7x42	h1_on	25.6241	2.94765	Yes	No	Yes	Yes	8	9
29	3x33	E2.F184	h1_on	84.6765	0	Yes	No	Yes	Yes	9	9
30	E2.F168	E2.F184	h1_on	93.5003	0	Yes	No	Yes	Yes	6	9
31	E2.F168	E2.Q170	h1_on	74.6833	0	Yes	No	No	No	6	5
32	E2.Q170	E2.Q171	h1_on	71.9844	0	No	No	Yes	No	5	2
33	E2.Q171	E2.V174	h1_on	34.6953	0	Yes	No	Yes	No	2	2
34	E2.V174	E2x51	h1_on	26.0814	0	Yes	No	Yes	No	2	7
35	3x22	E2x51	h1_on	46.4653	0	No	No	Yes	No	5	7
36	E2.Q171	E2.Y185	h1_on	28.8402	0	Yes	No	No	No	2	7
37	E2.Y185	E2x51	h1_on	26.1564	2.69248	No	No	Yes	No	7	7
38	3x22	E2.D183	h1_on	35.205	0	No	No	No	No	5	7
39	3x28	3x29	h1_on	10.3606	0	Yes	No	Yes	No	9	9
40	3x34	4x53	h1_on	24.5821	0	No	No	Yes	No	9	9
41	3x30	3x34	h1_on	10.0082	0	No	No	No	No	9	9
42	3x29	E2x52	h1_on	14.3489	0	Yes	No	No	No	9	9
43	3x36	Lig	h1_on	11.9124	0.818302	No	No	Yes	Yes	9	0
44	3x33	4x57	h1_on	17.9774	0.435548	Yes	No	Yes	Yes	9	8
45	3x37	4x57	h1_on	29.7399	9.26089	Yes	Yes	Yes	Yes	9	8
46	3x36	6x48	h1_on	16.0657	0.677519	No	No	Yes	Yes	9	9
47	6x48	6x52	h1_on	31.2017	0	Yes	Yes	Yes	No	9	9
48	5x47	6x44	h1_on	83.7094	0	Yes	Yes	Yes	Yes	9	9
49	5x54	6x44	h1_on	86.0559	0	Yes	Yes	Yes	Yes	9	9
50	3x46	3x50	h1_on	15.391	0	No	No	No	No	9	9
51	3x47	5x54	h1_on	73.9636	2.20414	No	No	Yes	Yes	8	9
52	3x47	5x57	h1_on	34.178	0	No	No	Yes	No	8	7
53	3x47	5x58	h1_on	45.3632	0	No	No	Yes	Yes	8	9
54	3x51	3x55	h1_on	11.5976	2.20414	Yes	Yes	No	No	9	8
55	I2x52	I2x57	h1_on	13.2169	0	No	Yes	No	Yes	5	9
56	2x42	4x42	h1_on	13.4868	4.75143	Yes	Yes	No	No	8	9
57	2x41	4x42	h1_on	10.8179	3.18082	No	No	No	No	8	9
58	3x34	4x54	h1_on	12.4747	1.59701	No	No	No	No	9	5
59	4x51	4x54	h1_on	10.0082	0	No	No	No	No	5	5
60	4x57	5x43	h1_on	32.3562	0.8315	Yes	Yes	No	No	8	8
61	4x60	5x39	h1_on	14.3414	2.82006	No	No	Yes	Yes	9	9
62	5x39	E2.F168	h1_on	16.3955	0	Yes	Yes	Yes	No	9	6
63	E2.D183	E2.W165	h1_on	29.38	1.27585	No	No	No	Yes	7	9
64	E2.N166	E2.W165	h1_on	17.67	1.52662	No	No	No	Yes	6	9
65	6x52	6x55	h1_on	54.7417	0	Yes	No	No	No	9	8
66	5x40	6x55	h1_on	51.8105	1.92697	No	No	No	No	9	8
67	5x40	6x58	h1_on	33.9006	0	No	No	No	No	9	6
68	6x58	7x30	h1_on	25.0618	0	No	No	No	No	6	6
69	5x40	6x59	h1_on	15.7733	0	No	No	No	No	9	8
70	5x48	6x53	h1_on	20.1289	0	No	No	No	No	8	7
71	5x62	6x37	h1_on	39.3058	0	Yes	No	No	No	8	9
72	5x62	5x66	h1_on	30.8944	2.20414	Yes	No	No	No	8	7
73	5x66	6x30	h1_on	24.687	0	No	No	No	No	7	8
74	6x29	6x30	h1_on	22.0031	0	Yes	No	No	No	8	8
75	6x25	6x29	h1_on	12.6771	0	No	No	Yes	No	5	8
76	6x40	7x53	h1_on	12.3173	1.56621	No	No	Yes	No	9	9
77	7x52	7x53	h1_on	12.6471	0	No	No	Yes	No	9	9
78	6x49	6x53	h1_on	17.3551	1.59261	No	No	No	No	8	7
79	6x47	7x45	h1_on	14.6113	1.49582	No	No	No	Yes	9	9
80	7x30	E3.C444	h1_on	12.6471	0	No	No	No	No	6	5
81	5x39	5x42	h1_on	14.9411	0	Yes	Yes	No	No	9	7
82	3x33	6x51	h1_on	37.7839	0	Yes	No	Yes	Yes	9	9
83	6x51	6x52	h1_on	51.0533	0	Yes	Yes	Yes	No	9	9
84	5x461	6x52	h1_on	18.9744	0	Yes	No	Yes	No	9	9
85	3x50	5x58	h1_on	15.226	0	No	No	Yes	Yes	9	9
86	3x43	7x53	h1_on	12.7071	0	No	No	Yes	No	9	9
87	3x37	5x461	h1_on	17.4901	8.3106	Yes	Yes	Yes	No	9	9
88	4x57	E2.F184	h1_on	10.3531	0	Yes	Yes	Yes	Yes	8	9
89	2x60	7x38	h1_on	11.1103	0	Yes	No	Yes	Yes	8	8
90	2x57	7x42	Shared	42.0571	26.674	Yes	Yes	Yes	Yes	9	9
91	2x53	7x46	Shared	52.5602	26.4364	No	No	No	No	9	9
92	2x50	7x46	Shared	52.3203	26.41	Yes	Yes	No	No	9	9
93	1x50	2x50	Shared	75.1631	15.0418	No	No	Yes	Yes	9	9
94	8x50	8x54	Shared	26.9436	35.033	Yes	No	Yes	Yes	9	9
95	8x50	I1x50	Shared	30.0247	45.6269	Yes	No	No	No	9	9
96	2x40	I1x50	Shared	28.1655	47.9323	No	No	No	No	9	9
97	2x46	7x53	Shared	37.3041	54.0519	Yes	No	Yes	No	9	9
98	2x45	4x46	Shared	21.5758	52.1205	No	No	No	No	9	9
99	2x42	4x46	Shared	21.0585	48.2402	Yes	Yes	No	No	8	9
100	2x50	7x49	Shared	13.3518	36.9688	Yes	Yes	No	No	9	9
101	3x33	Lig	Shared	68.3559	15.8293	Yes	No	Yes	Yes	9	0
102	E2.F184	E2x52	Shared	16.0357	13.7527	Yes	Yes	No	No	9	9
103	6x51	7x38	Shared	20.7962	13.3656	Yes	Yes	Yes	Yes	9	8
104	6x52	Lig	Shared	80.7482	28.8341	Yes	No	Yes	Yes	9	0
105	5x47	6x52	Shared	100	25.9481	Yes	Yes	Yes	No	9	9
106	3x44	5x54	Shared	15.0611	29.4897	No	No	Yes	Yes	8	9
107	3x51	5x57	Shared	25.834	17.0656	Yes	Yes	Yes	No	9	7
108	5x39	5x43	Shared	28.0756	30.4619	Yes	Yes	No	No	9	8
109	5x47	5x48	Shared	28.4729	12.5253	Yes	Yes	No	No	9	8
110	5x58	6x37	Shared	42.327	23.0048	Yes	Yes	No	No	9	9
111	6x48	7x45	Shared	42.6944	66.7708	Yes	Yes	No	Yes	9	9
112	7x39	7x42	Shared	12.2798	39.2301	Yes	Yes	Yes	Yes	9	9
113	2x54	2x57	Shared	20.3014	10.2508	No	No	Yes	Yes	9	9
114	3x28	E1x50	Shared	20.7287	32.4593	Yes	No	Yes	Yes	9	9
115	7x45	7x49	Shared	30.5495	84.4699	No	Yes	No	No	9	9
116	3x43	5x54	Shared	27.9481	67.7519	No	No	Yes	Yes	9	9
117	2x46	7x49	Shared	16.4855	100	Yes	No	No	No	9	9
118	1x39	7x39	h1_off	5.95997	15.4509	No	No	Yes	Yes	8	9
119	2x56	7x42	h1_off	1.55184	15.4817	No	Yes	Yes	Yes	9	9
120	2x53	2x56	h1_off	1.31194	28.6274	No	No	No	Yes	9	9
121	1x50	7x50	h1_off	6.94205	10.1672	No	No	No	No	9	9
122	2x43	7x53	h1_off	0	51.8038	No	No	Yes	No	9	9
123	2x40	2x43	h1_off	0	50.5279	No	No	No	No	9	9
124	3x32	7x42	h1_off	3.68843	22.6661	Yes	No	Yes	Yes	9	9
125	3x32	Lig	h1_off	2.40648	47.3647	Yes	No	Yes	Yes	9	0
126	6x48	Lig	h1_off	0	74.4215	Yes	Yes	Yes	Yes	9	0
127	7x38	7x42	h1_off	2.73634	38.7989	Yes	Yes	Yes	Yes	8	9
128	7x38	Lig	h1_off	0	27.6375	Yes	Yes	Yes	Yes	8	0
129	6x48	6x51	h1_off	0	22.4593	Yes	Yes	Yes	Yes	9	9
130	1x53	8x54	h1_off	0	11.0031	No	No	Yes	Yes	9	9
131	1x56	8x54	h1_off	0	10.6775	No	No	Yes	Yes	9	9
132	2x46	3x42	h1_off	0	59.6436	Yes	No	No	No	9	8
133	2x45	3x42	h1_off	5.03786	58.4118	No	No	No	No	9	8
134	2x56	3x28	h1_off	0	35.9569	No	Yes	Yes	No	9	9
135	2x63	E1x50	h1_off	0.217408	11.1703	No	No	Yes	Yes	7	9
136	1x35	1x39	h1_off	3.14866	12.5913	No	No	No	No	9	8
137	E1x50	E1x52	h1_off	9.91079	16.2121	Yes	Yes	No	No	9	9
138	3x33	E2x52	h1_off	0	14.8482	Yes	No	No	No	9	9
139	4x61	E2.F184	h1_off	0	24.7514	No	No	Yes	Yes	9	9
140	3x30	4x61	h1_off	0	22.3317	No	No	No	No	9	9
141	3x30	4x58	h1_off	7.5268	19.6216	No	No	No	No	9	5
142	4x58	4x62	h1_off	5.03036	16.7136	No	No	No	No	5	7
143	3x26	4x62	h1_off	2.51893	13.8011	No	No	No	No	8	7
144	3x22	3x26	h1_off	0	11.2978	No	No	No	No	5	8
145	5x43	Lig	h1_off	0	30.7215	No	No	Yes	Yes	8	0
146	5x39	E2.F184	h1_off	0	13.8099	Yes	Yes	Yes	Yes	9	9
147	3x37	3x41	h1_off	1.31944	11.751	Yes	Yes	No	No	9	8
148	3x40	Lig	h1_off	0	27.6023	No	No	Yes	Yes	9	0
149	3x40	6x44	h1_off	3.17865	26.6344	No	No	Yes	Yes	9	9
150	6x44	6x48	h1_off	0	30.1672	Yes	Yes	Yes	Yes	9	9
151	3x43	6x44	h1_off	0	69.6612	No	No	Yes	Yes	9	9
152	3x44	3x48	h1_off	0	25.363	No	No	No	No	8	6
153	3x48	5x57	h1_off	2.92376	23.3128	No	No	Yes	No	6	7
154	3x51	5x61	h1_off	8.74129	10.9107	Yes	Yes	No	No	9	9
155	2x42	3x49	h1_off	5.26276	37.4747	Yes	Yes	No	No	8	9
156	3x49	I2x57	h1_off	0	18.7813	No	No	No	Yes	9	9
157	3x52	I2x57	h1_off	0	15.0682	No	No	No	Yes	8	9
158	3x49	I2x53	h1_off	0	17.6067	No	No	No	Yes	9	9
159	3x52	I2x53	h1_off	0	15.0374	No	No	No	Yes	8	9
160	5x54	6x41	h1_off	0	35.3806	Yes	Yes	No	No	9	9
161	5x58	6x41	h1_off	9.48347	31.2758	Yes	Yes	No	No	9	9
162	8x47	8x50	h1_off	0	10.7039	No	No	Yes	No	9	9
163	6x54	7x34	h1_off	0	15.7633	No	No	No	Yes	7	7
164	7x54	8x54	h1_off	0	12.2305	No	No	Yes	Yes	9	9
165	3x52	I2x52	h1_off	2.03913	27.1535	No	No	No	Yes	8	5
166	I2x52	I2x56	h1_off	8.91371	15.1694	No	Yes	Yes	No	5	8
167	3x50	6x37	h1_off	0	20.9283	No	No	No	No	9	9
168	3x50	6x34	h1_off	0	17.7211	No	No	No	No	9	9
169	5x65	6x34	h1_off	0	15.6621	No	No	No	No	9	9
170	5x65	6x31	h1_off	0	14.0915	No	No	No	Yes	9	7
171	2x62	E1x52	h1_off	0	14.8438	No	No	No	No	6	9
172	2x62	2x66	h1_off	0	13.6912	No	No	No	Yes	6	5
173	7x54	8x51	h1_off	0	10.6907	No	No	No	No	9	8
174	7x35	7x39	h1_off	0	11.8038	No	No	Yes	Yes	6	9
175	2x56	3x32	h1_off	2.30902	23.9067	No	Yes	Yes	No	9	9
176	6x44	7x45	h1_off	0	19.3709	Yes	Yes	No	Yes	9	9
177	6x51	7x34	h1_off	0	11.5662	Yes	Yes	No	Yes	9	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	2x56	Shared	3.74333	3.21	0	1	2	2
2x56	3x32	Shared	7.3	13.15	1	1	2	1
2x56	7x42	Shared	6.73	5.05	1	1	2	1
2x57	7x39	Shared	5.04	4.65	1	1	2	2
2x57	7x42	Shared	6.78333	3.59	1	1	2	1
2x60	7x39	Shared	8.66333	3.39	1	1	2	2
2x60	7x42	Shared	3.87667	11.63	1	1	2	1
3x32	7x42	Shared	5.36667	13.79	1	1	1	1
3x32	Lig	Shared	11.5733	10.22	1	1	1	0
3x33	4x57	Shared	8.36	15.43	1	1	1	1
3x33	E2x52	h1_off	4.57667	0	1	1	1	2
3x33	Lig	Shared	15.9	19.86	1	1	1	0
3x36	6x48	Shared	4.12	4.94	1	1	1	1
3x36	Lig	Shared	9.95	7.07	1	1	1	0
3x37	3x41	Shared	4.75667	6.49	1	1	1	2
3x37	4x53	Shared	5.33333	3.2	1	1	1	2
3x37	4x57	Shared	7.28	9.7	1	1	1	1
3x37	5x461	Shared	7.31	10.24	1	1	1	1
3x40	5x50	h1_off	6.20667	0	0	0	1	2
3x40	6x44	Shared	7.95333	3.77	0	0	1	2
3x40	Lig	h1_off	4.59	0	0	0	1	0
4x57	5x43	Shared	7.68333	7.28	1	1	1	1
4x57	5x461	h1_off	9.04	0	1	1	1	1
4x57	Lig	h1_off	4.65667	0	1	1	1	0
E2.F184	E2x52	Shared	14.6967	5.19	1	1	2	2
5x39	E2.F184	h1_off	12.5033	0	1	0	2	2
5x39	5x43	Shared	3.89333	7.78	1	0	2	1
5x43	Lig	h1_off	3.62667	0	1	0	1	0
5x461	Lig	Shared	8.90333	7.75	1	1	1	0
5x47	6x52	Shared	27.8667	23.58	0	1	2	1
6x44	6x48	h1_off	6.01333	0	1	1	2	1
6x44	7x45	h1_off	7.24667	0	1	1	2	2
6x48	6x51	h1_off	7.39667	0	1	1	1	1
6x48	7x41	Shared	11.26	8.44	1	1	1	2
6x48	7x45	Shared	3.76667	9.04	1	1	1	2
6x48	Lig	h1_off	12.0133	0	1	1	1	0
6x51	6x55	h1_off	10.66	0	1	1	1	1
6x51	7x34	h1_off	4.71667	0	1	1	1	2
6x51	7x37	Shared	6.24333	4.99	1	1	1	2
6x51	7x38	Shared	5.24	4.84	1	1	1	1
6x51	Lig	Shared	11.23	24.27	1	1	1	0
6x52	Lig	Shared	16.8467	9.17	0	1	1	0
6x55	Lig	h1_off	6.30667	0	1	0	1	0
7x34	7x38	Shared	4.86	6.63	1	0	2	1
7x38	7x42	Shared	5.24	9.67	1	1	1	1
7x38	Lig	h1_off	4.99667	0	1	1	1	0
7x39	7x42	Shared	8.68333	3.86	1	1	2	1
5x40	6x55	Shared	7.03333	17.37	0	0	2	1
4x61	E2.F184	h1_off	3.35	0	0	0	2	2
5x44	6x52	h1_off	2.77	0	0	0	2	1
2x53	7x42	h1_on	0	3.79	0	1	2	1
2x60	7x38	h1_on	0	7.08	1	1	2	1
3x32	3x36	h1_on	0	4.42	1	1	1	1
3x33	4x61	h1_on	0	3.63	1	1	1	2
3x33	E2.F184	h1_on	0	6.19	1	1	1	2
3x33	6x51	h1_on	0	2.98	1	1	1	1
3x37	Lig	h1_on	0	5.55	1	1	1	0
3x40	6x48	h1_on	0	15.27	0	0	1	1
3x41	5x461	h1_on	0	7.25	0	1	2	1
4x57	E2.F184	h1_on	0	4.01	1	1	1	2
5x461	6x52	h1_on	0	6.04	1	1	1	1
5x47	6x44	h1_on	0	4.29	0	1	2	2
5x47	6x48	h1_on	0	3.01	0	1	2	1
6x48	6x52	h1_on	0	4.01	1	1	1	1
6x51	6x52	h1_on	0	6.19	1	1	1	1
6x52	6x55	h1_on	0	8.57	0	1	1	1
7x38	7x39	h1_on	0	3.52	1	1	1	2
7x42	Lig	h1_on	0	4.41	1	1	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	h1_off	8X63-H₁-Mepyramine 3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole
	h1_on	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2

Network Difference
Value	h1_on	h1_off
I_min	2.94	3.58
Number of Linked Nodes	251	275
Number of Specific Nodes	6 (2.39%)	30 (10.91%)
Number of Shared Nodes	245 (97.61%)	245 (89.09%)
Number of Links	299	295
Number of Specific Links	150 (50.17%)	146 (49.49%)
Number of Shared Links	149 (49.83%)	149 (50.51%)
Number of Hubs	45	29
Number of Specific Hubs	25 (55.56%)	9 (31.03%)
Number of Shared Hubs	20 (44.44%)	20 (68.97%)
Average % Shared Neighbours (Jaccard)	32.99
Average % Shared Neighbours (Otsuka)	43.02
Average % Shared Neighbours (Overlap Coefficient)	52.61
Average % Shared Cliques (k3-6)	52.60
Graphlets Similarity	0.587216

Paths Difference
Value	h1_on	h1_off
Number Of Nodes in MetaPath	103	82
Specific Nodes in MetaPath	53 (51.46%)	32 (39.02%)
Shared Nodes in MetaPath	245 (97.61%)	245 (97.61%)
Number Of Links MetaPath	117	88
Specific Links in MetaPath	89 (76.07%)	60 (68.18%)
Shared Links in MetaPath	149 (49.83%)	149 (49.83%)
Number of Shortest Paths	51809	56529
Length Of Smallest Path	3	3
Average Path Length	12.4035	13.657
Length of Longest Path	31	28
Minimum Path Strength	1.365	0.413333
Average Path Strength	6.68642	5.98084
Maximum Path Strength	19.01	22.3567
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.9223	0.9098
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.16667	4
Average % Of Corr. Nodes	54.6218	42.8823
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	51.451	36.2269
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download h1_off_on.zip<

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.