psnGPCR

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Orange: nodes, hubs and links specific of h1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of h1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	h1_off Int. Strength	h1_on Int. Strength	h1_off Hub1?	h1_on Hub1?	h1_off Hub2?	h1_on Hub2?	ConSurf1	ConSurf2
1	1x40	2x61	h1_off	3.8725	0	No	No	No	No	7	8
2	1x43	2x58	h1_off	3.2975	0	No	No	No	No	9	9
3	1x50	2x51	h1_off	3.78	0	No	No	No	No	9	8
4	1x53	8x54	h1_off	3.6025	0	No	No	Yes	Yes	9	9
5	1x54	2x47	h1_off	4.88	0	No	No	No	No	8	9
6	1x57	2x44	h1_off	4.81	0	No	No	No	No	8	8
7	1x58	2x44	h1_off	3.9225	0	No	No	No	No	6	8
8	1x60	I1x49	h1_off	3.375	0	No	No	No	No	8	7
9	1x60	8x53	h1_off	4.2325	0	No	No	No	No	8	8
10	I1x48	I1x51	h1_off	5.9225	0	No	No	No	No	8	8
11	2x40	2x43	h1_off	4.955	0	No	No	No	No	9	9
12	2x43	7x53	h1_off	10.2775	0	No	No	No	Yes	9	9
13	2x46	3x42	h1_off	4.505	0	No	Yes	No	No	9	8
14	2x56	3x28	h1_off	5.5175	0	Yes	No	No	Yes	9	9
15	3x22	3x26	h1_off	8.8075	0	No	No	No	No	5	8
16	3x30	4x61	h1_off	4.2575	0	No	No	No	No	9	9
17	3x33	E2x52	h1_off	4.0575	0	Yes	Yes	No	No	9	9
18	3x40	5x50	h1_off	6.3475	0	No	No	No	No	9	9
19	3x40	Lig	h1_off	4.4425	0	No	No	Yes	Yes	9	0
20	3x41	4x52	h1_off	4.265	0	No	No	No	No	8	7
21	3x44	3x48	h1_off	9.105	0	No	No	No	No	8	6
22	3x49	I2x57	h1_off	4.765	0	No	No	No	No	9	9
23	3x50	6x33	h1_off	4.84	0	No	No	No	No	9	9
24	3x50	6x37	h1_off	3.6425	0	No	No	No	No	9	9
25	3x53	I2x57	h1_off	4.945	0	No	No	No	No	9	9
26	3x56	I2x52	h1_off	5.2575	0	No	No	Yes	No	7	5
27	4x57	5x461	h1_off	6.78	0	Yes	Yes	No	Yes	8	9
28	4x57	Lig	h1_off	4.0175	0	Yes	Yes	Yes	Yes	8	0
29	5x39	E2.F184	h1_off	12.0575	0	Yes	Yes	No	Yes	9	9
30	5x36	5x38	h1_off	5.2125	0	No	No	No	No	8	5
31	5x43	Lig	h1_off	3.8225	0	No	No	Yes	Yes	8	0
32	5x45	5x48	h1_off	3.325	0	No	No	No	No	7	8
33	5x54	6x41	h1_off	6.5	0	Yes	Yes	No	No	9	9
34	5x56	5x60	h1_off	3.77	0	No	No	No	No	4	5
35	5x58	6x38	h1_off	5.43	0	Yes	Yes	No	No	9	8
36	5x68	6x31	h1_off	3.385	0	No	No	Yes	No	8	7
37	6x36	8x47	h1_off	4.95	0	No	No	No	No	9	9
38	6x39	7x56	h1_off	5.2375	0	No	No	No	No	7	9
39	6x43	7x45	h1_off	3.5175	0	No	No	Yes	No	8	9
40	6x44	6x48	h1_off	6.265	0	Yes	Yes	Yes	Yes	9	9
41	6x44	7x45	h1_off	7.8525	0	Yes	Yes	Yes	No	9	9
42	6x48	6x51	h1_off	5.7875	0	Yes	Yes	Yes	Yes	9	9
43	6x48	Lig	h1_off	12.45	0	Yes	Yes	Yes	Yes	9	0
44	6x51	6x55	h1_off	9.0275	0	Yes	Yes	No	No	9	8
45	6x54	7x34	h1_off	7.635	0	No	No	Yes	No	7	7
46	6x55	Lig	h1_off	6.795	0	No	No	Yes	Yes	8	0
47	7x31	7x34	h1_off	3.385	0	No	No	Yes	No	4	7
48	7x35	7x39	h1_off	4.3625	0	No	No	Yes	Yes	6	9
49	7x38	Lig	h1_off	4.085	0	Yes	Yes	Yes	Yes	8	0
50	7x54	8x54	h1_off	5.7775	0	No	No	Yes	Yes	9	9
51	8x47	8x50	h1_off	6.645	0	No	No	No	Yes	9	9
52	1x49	7x51	h1_off	3.805	0	No	No	No	No	9	7
53	2x63	E2.K179	h1_off	3.5825	0	No	No	No	No	7	4
54	3x22	E2.V174	h1_off	3.27	0	No	No	No	Yes	5	0
55	3x43	6x44	h1_off	3.2775	0	No	No	Yes	Yes	9	9
56	3x52	I2x53	h1_off	4.63	0	No	No	No	No	8	9
57	3x56	I2x51	h1_off	3.66	0	No	No	No	No	7	8
58	E2.M169	E2.W165	h1_off	5.235	0	No	No	Yes	No	0	9
59	E2.F184	E2.W165	h1_off	5.765	0	No	Yes	Yes	No	9	9
60	5x36	E2.W165	h1_off	3.37	0	No	No	Yes	No	8	9
61	5x39	E2.W165	h1_off	6.765	0	Yes	Yes	Yes	No	9	9
62	E2.D183	E2.N166	h1_off	3.7025	0	No	No	No	No	7	6
63	6x51	7x34	h1_off	6.26	0	Yes	Yes	Yes	No	9	7
64	E1x49	E2.D178	h1_off	3.4575	0	No	No	No	No	2	3
65	E2.Y185	E3.K442	h1_off	3.285	0	No	No	No	No	7	3
66	2x39	2x42	h1_off	3.2625	0	No	No	Yes	Yes	8	8
67	6x35	7x56	h1_off	3.2325	0	No	No	No	No	7	9
68	2x59	3x24	h1_off	3.1775	0	No	Yes	No	No	8	7
69	2x41	4x39	h1_off	3.1725	0	No	No	No	No	8	8
70	5x47	6x49	h1_off	3.1375	0	Yes	Yes	No	No	9	8
71	3x48	3x52	h1_off	3.1325	0	No	No	No	No	6	8
72	6x39	7x55	h1_off	3.045	0	No	No	No	No	7	8
73	5x51	6x45	h1_off	3.04	0	No	No	No	No	9	8
74	E2.Q171	E2.W165	h1_off	3.0125	0	No	Yes	Yes	No	0	9
75	2x53	3x35	h1_off	2.9675	0	No	No	No	No	9	8
76	5x65	6x31	h1_off	2.9425	0	No	No	Yes	No	9	7
77	5x65	6x30	h1_off	2.855	0	No	No	No	No	9	8
78	8x52	8x56	h1_off	2.785	0	No	No	No	No	7	6
79	6x25	6x31	h1_off	2.7325	0	No	No	Yes	No	5	7
80	6x27	6x30	h1_off	2.7075	0	No	No	No	No	3	8
81	E2.D178	E2.R176	h1_off	2.68	0	No	No	No	No	3	1
82	5x69	6x30	h1_off	2.6525	0	No	No	No	No	5	8
83	5x67	5x68	h1_off	2.6275	0	No	No	No	No	5	8
84	3x30	4x62	h1_off	2.625	0	No	No	No	No	9	7
85	2x49	3x39	h1_off	2.565	0	No	No	No	No	9	9
86	7x30	7x32	h1_off	2.55	0	No	No	No	No	6	2
87	3x22	3x23	h1_off	2.52	0	No	No	No	No	5	5
88	4x38	I2x56	h1_off	2.4975	0	No	No	Yes	Yes	9	8
89	E2.K179	E2.R176	h1_off	2.4775	0	No	No	No	No	4	1
90	6x58	E3.C445	h1_off	2.455	0	No	No	No	No	6	5
91	4x47	4x51	h1_off	2.435	0	No	No	No	No	7	5
92	5x44	6x52	h1_off	2.425	0	No	No	Yes	Yes	9	9
93	3x34	4x58	h1_off	2.4025	0	No	No	No	No	9	5
94	1x60	I1x50	h1_off	2.32	0	No	No	Yes	No	8	9
95	NT.P25	NT.S24	h1_off	2.225	0	No	No	No	No	0	0
96	2x52	3x31	h1_off	2.1875	0	No	No	No	No	8	8
97	5x46	5x49	h1_off	2.14	0	No	No	No	No	5	7
98	5x64	5x67	h1_off	2.075	0	No	No	No	No	6	5
99	8x49	I1x50	h1_off	2.0575	0	No	No	Yes	No	9	9
100	1x55	8x56	h1_off	2.0575	0	No	No	No	No	5	6
101	E1x50	E2.R175	h1_off	2	0	Yes	Yes	No	No	9	4
102	7x32	7x33	h1_off	1.93	0	No	No	No	No	2	4
103	6x28	6x31	h1_off	1.8075	0	No	No	Yes	No	7	7
104	6x54	E3.C445	h1_off	1.745	0	No	No	No	No	7	5
105	6x60	6x61	h1_off	1.745	0	No	No	No	No	7	7
106	3x41	4x49	h1_off	1.735	0	No	No	No	No	8	7
107	5x41	6x59	h1_off	1.7	0	No	No	No	No	8	8
108	5x65	6x34	h1_off	1.6975	0	No	No	No	No	9	9
109	6x32	8x48	h1_off	1.6875	0	No	No	No	No	9	5
110	8x48	8x51	h1_off	1.6875	0	No	No	No	No	5	8
111	8x53	8x56	h1_off	1.615	0	No	No	No	No	8	6
112	2x44	2x47	h1_off	1.615	0	No	No	No	No	8	9
113	4x63	E2.H167	h1_off	1.59	0	No	No	No	No	7	4
114	NT.A23	NT.L27	h1_off	1.575	0	No	No	No	No	0	0
115	4x43	4x46	h1_off	1.5475	0	No	No	No	No	6	9
116	I2x52	I2x54	h1_off	1.5175	0	Yes	No	No	No	5	8
117	1x42	2x57	h1_off	1.46	0	No	No	Yes	Yes	7	9
118	2x62	2x66	h1_off	1.4125	0	No	No	No	No	6	5
119	2x62	E1x52	h1_off	1.3825	0	No	No	No	No	6	9
120	1x47	2x55	h1_off	1.275	0	No	No	No	No	6	7
121	E2.F168	E2.M169	h1_off	1.245	0	No	Yes	No	No	0	0
122	1x36	1x37	h1_off	1.2025	0	No	No	No	No	7	4
123	I2x55	I2x56	h1_off	1.195	0	No	No	Yes	Yes	5	8
124	1x36	2x61	h1_off	1.155	0	No	No	No	No	7	8
125	4x43	4x47	h1_off	1.125	0	No	No	No	No	6	7
126	1x35	1x38	h1_off	1.1175	0	No	No	No	No	9	4
127	E1.S91	E2.E177	h1_off	1.0775	0	No	No	No	No	3	3
128	7x40	7x43	h1_off	1.0725	0	No	No	No	No	9	6
129	2x65	NT.M28	h1_off	1.06	0	No	No	No	No	6	5
130	4x52	4x55	h1_off	1.0375	0	No	No	No	No	7	5
131	1x35	NT.L27	h1_off	1.0375	0	No	No	No	No	9	0
132	5x38	5x42	h1_off	0.8725	0	No	No	No	No	5	7
133	1x48	1x51	h1_off	0.855	0	No	No	No	No	6	8
134	4x62	4x63	h1_off	0.855	0	No	No	No	No	7	7
135	7x54	8x51	h1_off	0.835	0	No	No	No	No	9	8
136	1x41	1x45	h1_off	0.795	0	No	No	No	No	5	4
137	2x66	NT.T21	h1_off	0.7525	0	No	No	No	No	5	0
138	5x51	5x52	h1_off	0.735	0	No	No	No	No	9	5
139	8x51	8x55	h1_off	0.7175	0	No	No	No	No	8	8
140	8x58	8x59	h1_off	0.6425	0	No	No	No	No	8	6
141	6x29	6x32	h1_off	0.62	0	No	Yes	No	No	8	9
142	5x58	5x62	h1_off	0.4975	0	Yes	Yes	No	Yes	9	8
143	E3.C444	E3.N443	h1_off	0.3925	0	No	No	No	No	5	4
144	NT.M22	NT.T20	h1_off	0.3775	0	No	No	No	No	0	0
145	1x41	1x44	h1_off	0.3675	0	No	No	No	No	5	7
146	NT.Q26	NT.S24	h1_off	0.36	0	No	No	No	No	0	0
147	5x63	5x67	h1_off	0.31	0	No	No	No	No	6	5
148	1x36	2x65	Shared	4.0975	1.49	No	No	No	No	7	6
149	1x39	7x39	Shared	16.8	11.39	No	No	Yes	Yes	8	9
150	1x43	2x57	Shared	5.6725	4.86	No	No	Yes	Yes	9	9
151	1x46	2x57	Shared	3.39	9.03	No	Yes	Yes	Yes	9	9
152	1x46	7x47	Shared	10.99	10.99	No	Yes	No	No	9	9
153	1x49	7x50	Shared	4.1025	3.28	No	No	No	No	9	9
154	1x50	2x50	Shared	9.09	6.73	No	No	No	Yes	9	9
155	1x50	7x50	Shared	9.775	13.03	No	No	No	No	9	9
156	1x51	2x51	Shared	3.4575	2.77	No	No	No	No	8	8
157	1x52	8x54	Shared	6.7	4.87	No	No	Yes	Yes	9	9
158	1x53	2x47	Shared	5.25	6.46	No	No	No	No	9	9
159	1x54	2x48	Shared	3.725	1.49	No	No	No	No	8	6
160	2x40	I1x50	Shared	5.15	5.49	No	No	Yes	No	9	9
161	8x50	I1x50	Shared	6.0875	7.31	No	Yes	Yes	No	9	9
162	2x37	2x40	Shared	7.675	7.31	No	No	No	No	9	9
163	2x38	I2x57	Shared	8.175	5.23	No	Yes	No	No	9	9
164	2x42	3x45	Shared	5.44	4.84	Yes	Yes	No	Yes	8	8
165	2x42	3x46	Shared	5.57	5.86	Yes	Yes	No	No	8	9
166	2x42	3x49	Shared	12.9275	13.79	Yes	Yes	No	No	8	9
167	2x42	4x42	Shared	4.6675	2.67	Yes	Yes	No	No	8	9
168	2x42	4x45	Shared	3.4375	6.24	Yes	Yes	No	No	8	8
169	2x45	3x42	Shared	6.52	4.89	No	No	No	No	9	8
170	2x45	4x50	Shared	4.9425	4.94	No	No	No	Yes	9	9
171	2x46	7x49	Shared	3.7775	10.98	No	Yes	No	No	9	9
172	2x46	7x53	Shared	5.275	3.52	No	Yes	No	Yes	9	9
173	2x50	3x39	Shared	3.3125	5.89	No	Yes	No	No	9	9
174	2x50	7x46	Shared	9.2	10.31	No	Yes	No	No	9	9
175	2x53	7x46	Shared	4.0375	8.08	No	No	No	No	9	9
176	2x54	2x57	Shared	3.4925	6.99	No	No	Yes	Yes	9	9
177	2x551	3x31	Shared	5.325	9.13	No	No	No	No	6	8
178	2x56	3x32	Shared	7.665	13.15	Yes	No	No	Yes	9	9
179	2x56	7x42	Shared	7.8875	5.05	Yes	No	Yes	Yes	9	9
180	2x57	7x39	Shared	5.235	4.65	Yes	Yes	Yes	Yes	9	9
181	2x57	7x42	Shared	5.0875	3.59	Yes	Yes	Yes	Yes	9	9
182	2x59	3x28	Shared	9.8875	16.29	No	Yes	No	Yes	8	9
183	2x60	7x39	Shared	8.475	3.39	No	Yes	Yes	Yes	8	9
184	2x63	E1x50	Shared	8.44	12.54	No	No	Yes	Yes	7	9
185	2x64	7x35	Shared	6.715	2.83	No	No	No	No	8	6
186	E1x50	E1x52	Shared	4.555	12.53	Yes	Yes	No	No	9	9
187	3x25	E1x50	Shared	5.5525	7.84	No	No	Yes	Yes	9	9
188	3x25	E2x50	Shared	7.28	7.28	No	No	No	Yes	9	9
189	3x27	3x31	Shared	9.02	9.95	No	No	No	No	8	8
190	3x30	4x58	Shared	5.655	3.23	No	No	No	No	9	5
191	3x32	7x42	Shared	6.0375	13.79	No	Yes	Yes	Yes	9	9
192	3x32	Lig	Shared	11.63	9.84	No	Yes	Yes	Yes	9	0
193	3x33	4x57	Shared	8.2	15.43	Yes	Yes	Yes	Yes	9	8
194	3x33	Lig	Shared	20.925	19.12	Yes	Yes	Yes	Yes	9	0
195	3x34	4x54	Shared	9.175	1.31	No	No	No	No	9	5
196	3x36	Lig	Shared	9.5325	6.8	No	No	Yes	Yes	9	0
197	3x37	3x41	Shared	4.865	6.49	Yes	Yes	No	No	9	8
198	3x37	4x53	Shared	5.6	3.2	Yes	Yes	No	Yes	9	9
199	3x37	4x57	Shared	6.975	9.7	Yes	Yes	Yes	Yes	9	8
200	3x37	5x461	Shared	6.58	10.24	Yes	Yes	No	Yes	9	9
201	3x38	4x50	Shared	7.4575	9.08	No	No	No	Yes	9	9
202	3x40	6x44	Shared	6.5925	3.77	No	No	Yes	Yes	9	9
203	3x43	5x54	Shared	3.8025	4.56	No	No	Yes	Yes	9	9
204	3x44	5x53	Shared	6.09	4.87	No	No	No	No	8	6
205	3x44	5x54	Shared	5.5975	3.73	No	No	Yes	Yes	8	9
206	3x45	4x45	Shared	8.74	4.56	No	Yes	No	No	8	8
207	3x47	5x54	Shared	4.86	6.48	No	No	Yes	Yes	8	9
208	3x48	5x57	Shared	5.6525	8.79	No	No	No	Yes	6	7
209	3x51	3x55	Shared	3.3825	14.65	Yes	Yes	No	No	9	8
210	3x51	5x60	Shared	10.7475	7.17	Yes	Yes	No	No	9	5
211	3x52	I2x52	Shared	4.7975	17.06	No	No	Yes	No	8	5
212	I2x52	I2x56	Shared	5.4	11.32	Yes	No	Yes	Yes	5	8
213	4x41	I2x56	Shared	7.46	12.35	No	No	Yes	Yes	9	8
214	4x57	5x43	Shared	7.885	7.28	Yes	Yes	No	No	8	8
215	4x59	4x60	Shared	3.39	3.39	No	No	No	No	8	9
216	E2.N166	E2.W165	Shared	3.39	6.78	No	No	Yes	No	6	9
217	E2.D183	E2.W165	Shared	7.8175	1.12	No	No	Yes	No	7	9
218	E2.R176	E2x51	Shared	4.07	3.49	No	No	No	Yes	1	7
219	E2.Y185	E2x51	Shared	15.1525	7.86	No	No	No	Yes	7	7
220	E2.F184	E2x52	Shared	12.9675	5.19	No	Yes	No	No	9	9
221	E2.D186	E2.Y185	Shared	4.6	13.79	No	No	No	No	3	7
222	5x38	5x39	Shared	5.5125	1	No	No	Yes	Yes	5	9
223	5x39	5x43	Shared	3.5675	7.78	Yes	Yes	No	No	9	8
224	5x40	6x55	Shared	8.3775	17.37	No	No	No	No	9	8
225	5x461	Lig	Shared	9.2975	7.46	No	Yes	Yes	Yes	9	0
226	5x47	5x48	Shared	5.4175	14.44	Yes	Yes	No	No	9	8
227	5x47	5x51	Shared	4.8625	11.67	Yes	Yes	No	No	9	9
228	5x47	6x52	Shared	30.545	23.58	Yes	Yes	Yes	Yes	9	9
229	5x56	5x57	Shared	4.51	6.01	No	No	No	Yes	4	7
230	5x58	6x41	Shared	4.19	2.39	Yes	Yes	No	No	9	9
231	5x62	5x66	Shared	9.2325	3.09	No	Yes	No	No	8	7
232	6x36	7x56	Shared	5.34	9.16	No	No	No	No	9	9
233	6x39	7x52	Shared	4.085	10.05	No	No	No	No	7	9
234	6x40	7x53	Shared	3.63	4.84	No	No	No	Yes	9	9
235	6x47	7x45	Shared	8.2675	9.45	No	No	Yes	No	9	9
236	6x48	7x41	Shared	9.8525	8.44	Yes	Yes	No	No	9	9
237	6x49	6x50	Shared	5.08	3.39	No	No	No	No	8	9
238	6x51	6x52	Shared	3.35	6.19	Yes	Yes	Yes	Yes	9	9
239	6x51	7x37	Shared	6.8675	4.99	Yes	Yes	No	No	9	9
240	6x51	7x38	Shared	5.14	4.84	Yes	Yes	Yes	Yes	9	8
241	6x51	Lig	Shared	12.45	23.36	Yes	Yes	Yes	Yes	9	0
242	6x52	Lig	Shared	15.515	8.83	Yes	Yes	Yes	Yes	9	0
243	6x54	7x33	Shared	4.87	8.53	No	No	No	No	7	4
244	6x61	E3.C444	Shared	7.28	7.28	No	No	No	No	7	5
245	7x38	7x42	Shared	4.8375	9.67	Yes	Yes	Yes	Yes	8	9
246	7x39	7x42	Shared	8.4425	3.86	Yes	Yes	Yes	Yes	9	9
247	7x42	Lig	Shared	3.6425	4.25	Yes	Yes	Yes	Yes	9	0
248	7x45	7x49	Shared	7.1525	12.26	Yes	No	No	No	9	9
249	8x50	8x54	Shared	5.0925	5.36	No	Yes	Yes	Yes	9	9
250	2x45	4x46	Shared	5.4175	9.29	No	No	No	No	9	9
251	E1x50	E2x50	Shared	4.8975	7.84	Yes	Yes	No	Yes	9	9
252	3x33	4x61	Shared	4.23	3.63	Yes	Yes	No	No	9	9
253	3x51	5x57	Shared	10.315	12.38	Yes	Yes	No	Yes	9	7
254	3x54	5x61	Shared	3.4575	4.61	No	No	No	No	9	9
255	5x48	6x56	Shared	3.89	4.79	No	No	No	No	8	7
256	7x34	7x38	Shared	4.97	6.63	Yes	No	Yes	Yes	7	8
257	5x58	6x37	Shared	3.2225	3.52	Yes	Yes	No	No	9	9
258	2x53	2x56	Shared	3.2075	3.21	No	No	Yes	No	9	9
259	1x55	1x59	Shared	3.1825	5.09	No	No	No	No	5	7
260	7x36	7x40	Shared	3.045	9.74	No	No	No	No	5	9
261	2x42	4x46	Shared	3.025	4.84	Yes	Yes	No	No	8	9
262	3x51	5x61	Shared	3.0225	3.63	Yes	Yes	No	No	9	9
263	1x56	8x53	Shared	2.9375	1.68	No	No	No	No	9	8
264	7x43	7x48	Shared	2.85	2.85	No	No	No	No	6	8
265	2x52	3x35	Shared	2.8425	3.25	No	No	No	No	8	8
266	2x61	7x39	Shared	2.6425	4.7	No	No	Yes	Yes	8	9
267	4x39	I1x51	Shared	2.62	6.55	No	No	No	No	8	8
268	3x28	E1x50	Shared	2.5775	8.43	No	Yes	Yes	Yes	9	9
269	6x50	7x40	Shared	2.4625	3.28	No	No	No	No	9	9
270	3x29	E2x50	Shared	2.38	4.76	No	Yes	No	Yes	9	9
271	3x56	I2x50	Shared	2.37	7.9	No	No	No	No	7	9
272	4x38	4x40	Shared	2.355	4.71	No	No	No	No	9	6
273	5x41	5x45	Shared	2.3025	1.54	No	No	No	No	8	7
274	1x45	1x49	Shared	2.235	4.47	No	No	No	No	4	9
275	1x34	NT.M28	Shared	2.0975	1.68	No	No	No	No	3	5
276	3x26	4x62	Shared	2.075	5.54	No	No	No	No	8	7
277	5x49	5x50	Shared	2.05	3.28	No	No	No	No	7	9
278	6x57	E3.C444	Shared	1.71	1.71	No	No	No	No	8	5
279	3x54	5x64	Shared	1.7	1.7	No	No	No	No	9	6
280	3x21	3x23	Shared	1.5225	2.03	No	No	No	No	8	5
281	2x38	4x39	Shared	1.5175	1.52	No	Yes	No	No	9	8
282	4x48	4x51	Shared	1.51	1.51	No	No	No	No	5	5
283	6x49	6x53	Shared	1.4725	2.94	No	No	No	No	8	7
284	5x55	6x41	Shared	1.4125	4.24	No	No	No	No	7	9
285	1x35	1x39	Shared	1.3825	1.38	No	No	No	No	9	8
286	1x47	2x54	Shared	1.38	1.84	No	No	No	No	6	9
287	4x60	5x39	Shared	1.0825	4.33	No	No	Yes	Yes	9	9
288	6x59	6x60	Shared	1.04	1.39	No	No	No	No	8	7
289	5x37	6x59	Shared	0.84	3.36	No	No	No	No	8	8
290	2x66	E1x51	Shared	0.7675	6.13	No	No	No	No	5	5
291	E1.S91	E1x49	Shared	0.765	1.53	No	No	No	No	3	2
292	1x55	8x57	Shared	0.605	10.88	No	No	No	No	5	8
293	1x38	1x42	h1_on	0	3.07	No	No	No	No	4	7
294	1x46	2x54	h1_on	0	3.64	No	Yes	No	No	9	9
295	1x47	1x48	h1_on	0	3.68	No	No	No	No	6	6
296	1x47	1x51	h1_on	0	2.98	No	No	No	No	6	8
297	1x50	2x47	h1_on	0	2.98	No	No	No	No	9	9
298	1x53	7x54	h1_on	0	3.53	No	No	No	No	9	9
299	1x54	1x58	h1_on	0	9.72	No	No	No	No	8	6
300	1x59	1x60	h1_on	0	4.31	No	No	No	No	7	8
301	2x37	2x38	h1_on	0	3.17	No	No	No	Yes	9	9
302	2x38	2x39	h1_on	0	3.68	No	Yes	No	No	9	8
303	2x40	8x47	h1_on	0	5.45	No	No	No	No	9	9
304	2x43	7x54	h1_on	0	6.77	No	No	No	No	9	9
305	2x46	2x50	h1_on	0	5.43	No	Yes	No	Yes	9	9
306	2x46	3x43	h1_on	0	4.47	No	Yes	No	No	9	9
307	2x48	2x52	h1_on	0	3.07	No	No	No	No	6	8
308	2x49	4x50	h1_on	0	3.89	No	No	No	Yes	9	9
309	2x50	7x49	h1_on	0	9.42	No	Yes	No	No	9	9
310	2x53	7x42	h1_on	0	3.79	No	No	Yes	Yes	9	9
311	2x59	E1x50	h1_on	0	8.14	No	Yes	Yes	Yes	8	9
312	2x60	3x28	h1_on	0	11.3	No	Yes	No	Yes	8	9
313	2x60	7x38	h1_on	0	7.08	No	Yes	Yes	Yes	8	8
314	2x60	7x42	h1_on	0	11.63	No	Yes	Yes	Yes	8	9
315	2x63	3x28	h1_on	0	5.79	No	No	No	Yes	7	9
316	2x63	E2x50	h1_on	0	5.38	No	No	No	Yes	7	9
317	2x64	7x39	h1_on	0	3.42	No	No	Yes	Yes	8	9
318	E1x49	E2.E177	h1_on	0	6.75	No	No	No	No	2	3
319	3x24	E1x50	h1_on	0	3.42	No	No	Yes	Yes	7	9
320	3x24	E1x52	h1_on	0	9.69	No	No	No	No	7	9
321	3x22	E2.R175	h1_on	0	23.46	No	No	No	No	5	4
322	3x22	E2.D183	h1_on	0	3.57	No	No	No	No	5	7
323	3x25	3x29	h1_on	0	3.17	No	No	No	Yes	9	9
324	3x28	3x29	h1_on	0	5.69	No	Yes	No	Yes	9	9
325	3x29	E2x52	h1_on	0	4.42	No	Yes	No	No	9	9
326	3x32	3x36	h1_on	0	4.42	No	Yes	No	No	9	9
327	3x33	E2.F184	h1_on	0	6.19	Yes	Yes	No	Yes	9	9
328	3x33	6x51	h1_on	0	2.98	Yes	Yes	Yes	Yes	9	9
329	3x36	6x48	h1_on	0	4.94	No	No	Yes	Yes	9	9
330	3x37	Lig	h1_on	0	5.34	Yes	Yes	Yes	Yes	9	0
331	3x38	4x53	h1_on	0	3.42	No	No	No	Yes	9	9
332	3x40	6x48	h1_on	0	15.27	No	No	Yes	Yes	9	9
333	3x41	5x461	h1_on	0	7.25	No	No	No	Yes	8	9
334	3x42	3x45	h1_on	0	3.1	No	No	No	Yes	8	8
335	3x43	7x53	h1_on	0	7.57	No	No	No	Yes	9	9
336	3x44	5x50	h1_on	0	4.33	No	No	No	No	8	9
337	3x45	4x49	h1_on	0	3.25	No	Yes	No	No	8	7
338	3x46	3x50	h1_on	0	6.07	No	No	No	No	9	9
339	3x46	7x53	h1_on	0	8.21	No	No	No	Yes	9	9
340	3x47	5x57	h1_on	0	4.19	No	No	No	Yes	8	7
341	3x47	5x58	h1_on	0	14.79	No	No	Yes	Yes	8	9
342	3x49	3x53	h1_on	0	4.42	No	No	No	No	9	9
343	3x50	5x58	h1_on	0	3.09	No	No	Yes	Yes	9	9
344	3x52	I2x56	h1_on	0	3.09	No	No	Yes	Yes	8	8
345	3x55	3x56	h1_on	0	3.84	No	No	No	No	8	7
346	3x55	5x60	h1_on	0	6.78	No	No	No	No	8	5
347	I2x52	I2x57	h1_on	0	3.2	Yes	No	No	No	5	9
348	I2x53	I2x54	h1_on	0	5.86	No	No	No	No	9	8
349	I2x54	I2x56	h1_on	0	14.07	No	No	Yes	Yes	8	8
350	4x40	4x43	h1_on	0	3.2	No	No	No	No	6	6
351	4x50	4x53	h1_on	0	3.71	No	Yes	No	Yes	9	9
352	4x51	4x54	h1_on	0	3.22	No	No	No	No	5	5
353	4x57	E2.F184	h1_on	0	4.01	Yes	Yes	No	Yes	8	9
354	E2.T172	E2.W165	h1_on	0	3.64	No	No	Yes	No	0	9
355	E2.H167	E2.N166	h1_on	0	15.31	No	No	No	No	4	6
356	E2.F168	E2.F184	h1_on	0	7.5	No	Yes	No	Yes	0	9
357	5x36	E2.F168	h1_on	0	10.49	No	No	No	Yes	8	0
358	5x39	E2.F168	h1_on	0	5.36	Yes	Yes	No	Yes	9	0
359	E2.Q170	E2.Q171	h1_on	0	5.12	No	No	No	Yes	0	0
360	E2.Q171	E2.V174	h1_on	0	10.03	No	Yes	No	Yes	0	0
361	E2.Q171	E2.Y185	h1_on	0	6.76	No	Yes	No	No	0	7
362	E2.D186	E2.Q171	h1_on	0	14.36	No	No	No	Yes	3	0
363	E2.R176	E2.V174	h1_on	0	9.15	No	No	No	Yes	1	0
364	E2.V174	E2x51	h1_on	0	8.56	No	Yes	No	Yes	0	7
365	7x31	E2.D178	h1_on	0	3.9	No	No	No	No	4	3
366	7x31	E2.K179	h1_on	0	8.1	No	No	No	No	4	4
367	5x40	6x58	h1_on	0	4.36	No	No	No	No	9	6
368	5x44	6x56	h1_on	0	3.22	No	No	No	No	9	7
369	5x461	6x52	h1_on	0	6.04	No	Yes	Yes	Yes	9	9
370	5x47	6x44	h1_on	0	4.29	Yes	Yes	Yes	Yes	9	9
371	5x47	6x48	h1_on	0	3.01	Yes	Yes	Yes	Yes	9	9
372	5x48	6x53	h1_on	0	4.84	No	No	No	No	8	7
373	5x49	5x53	h1_on	0	4.15	No	No	No	No	7	6
374	5x51	6x44	h1_on	0	7.78	No	No	Yes	Yes	9	9
375	5x54	6x44	h1_on	0	8.71	Yes	Yes	Yes	Yes	9	9
376	5x62	6x34	h1_on	0	4	No	Yes	No	No	8	9
377	5x65	6x29	h1_on	0	3.92	No	No	No	Yes	9	8
378	5x66	5x68	h1_on	0	6.77	No	No	No	No	7	8
379	5x66	6x30	h1_on	0	3.49	No	No	No	No	7	8
380	5x67	6x29	h1_on	0	16.35	No	No	No	Yes	5	8
381	5x68	6x30	h1_on	0	12.31	No	No	No	No	8	8
382	6x25	6x28	h1_on	0	4.12	No	No	No	No	5	7
383	6x25	6x29	h1_on	0	3.64	No	No	No	Yes	5	8
384	6x27	6x28	h1_on	0	4.21	No	No	No	No	3	7
385	6x29	6x30	h1_on	0	11.63	No	Yes	No	No	8	8
386	6x36	6x40	h1_on	0	5.49	No	No	No	No	9	9
387	6x38	6x41	h1_on	0	5.24	No	No	No	No	8	9
388	6x45	6x46	h1_on	0	5.71	No	No	No	No	8	5
389	6x45	6x49	h1_on	0	4.42	No	No	No	No	8	8
390	6x48	6x52	h1_on	0	4.01	Yes	Yes	Yes	Yes	9	9
391	6x48	7x45	h1_on	0	9.04	Yes	Yes	Yes	No	9	9
392	6x52	6x55	h1_on	0	8.57	Yes	Yes	No	No	9	8
393	6x54	6x58	h1_on	0	3.77	No	No	No	No	7	6
394	6x58	7x30	h1_on	0	7.08	No	No	No	No	6	6
395	6x61	E3.N443	h1_on	0	4.72	No	No	No	No	7	4
396	7x30	7x31	h1_on	0	10.52	No	No	No	No	6	4
397	7x38	7x39	h1_on	0	3.52	Yes	Yes	Yes	Yes	8	9
398	7x52	7x53	h1_on	0	3.63	No	No	No	Yes	9	9
399	8x47	8x48	h1_on	0	9.2	No	No	No	No	9	5
400	8x48	8x50	h1_on	0	4.66	No	No	No	Yes	5	9
401	8x53	8x54	h1_on	0	5.19	No	No	Yes	Yes	8	9
402	5x42	5x46	h1_on	0	2.92	No	No	No	No	7	5
403	7x54	8x50	h1_on	0	2.89	No	No	No	Yes	9	9
404	1x52	CT.I485	h1_on	0	2.85	No	No	No	No	9	8
405	2x59	2x62	h1_on	0	2.83	No	Yes	No	No	8	6
406	3x21	E1x50	h1_on	0	2.81	No	No	Yes	Yes	8	9
407	5x62	6x33	h1_on	0	2.67	No	Yes	No	No	8	9
408	6x26	6x27	h1_on	0	2.63	No	No	No	No	5	3
409	5x39	5x42	h1_on	0	2.49	Yes	Yes	No	No	9	7
410	7x55	8x54	h1_on	0	2.44	No	No	Yes	Yes	8	9
411	2x52	4x50	h1_on	0	2.35	No	No	No	Yes	8	9
412	E2.F168	E2.Q170	h1_on	0	2.34	No	Yes	No	No	0	0
413	5x62	6x37	h1_on	0	2.34	No	Yes	No	No	8	9
414	3x22	E2x51	h1_on	0	2.33	No	No	No	Yes	5	7
415	1x40	1x43	h1_on	0	1.72	No	No	No	No	7	9
416	4x47	4x48	h1_on	0	1.71	No	No	No	No	7	5
417	6x57	6x61	h1_on	0	1.71	No	No	No	No	8	7
418	2x55	2x551	h1_on	0	1.7	No	No	No	No	7	6
419	4x63	E2.N166	h1_on	0	1.7	No	No	No	No	7	6
420	2x57	2x58	h1_on	0	1.68	Yes	Yes	No	No	9	9
421	2x58	2x59	h1_on	0	1.68	No	No	No	Yes	9	8
422	I2x50	I2x51	h1_on	0	1.64	No	No	No	No	9	8
423	1x36	1x40	h1_on	0	1.62	No	No	No	No	7	7
424	1x56	8x57	h1_on	0	1.62	No	No	No	No	9	8
425	3x30	3x34	h1_on	0	1.62	No	No	No	No	9	9
426	3x34	4x53	h1_on	0	1.62	No	No	No	Yes	9	9
427	E2.S173	E2.V174	h1_on	0	1.62	No	No	No	Yes	0	0
428	6x43	7x52	h1_on	0	1.62	No	No	No	No	8	9
429	5x40	6x59	h1_on	0	1.61	No	No	No	No	9	8
430	2x44	2x48	h1_on	0	1.6	No	No	No	No	8	6
431	1x43	1x44	h1_on	0	1.59	No	No	No	No	9	7
432	5x37	5x41	h1_on	0	1.59	No	No	No	No	8	8
433	6x47	7x48	h1_on	0	1.59	No	No	No	No	9	8
434	2x41	4x42	h1_on	0	1.58	No	No	No	No	8	9
435	2x51	2x55	h1_on	0	1.58	No	No	No	No	8	7
436	7x30	E3.C444	h1_on	0	1.57	No	No	No	No	6	5
437	1x42	1x46	h1_on	0	1.52	No	No	No	Yes	7	9
438	2x41	4x43	h1_on	0	1.5	No	No	No	No	8	6
439	E1x51	E1x52	h1_on	0	1.5	No	No	No	No	5	9
440	1x54	2x44	h1_on	0	1.49	No	No	No	No	8	8
441	4x58	4x62	h1_on	0	1.49	No	No	No	No	5	7
442	1x35	2x64	h1_on	0	1.38	No	No	No	No	9	8
443	1x52	8x58	h1_on	0	1.38	No	No	No	No	9	8
444	E2.D186	E3.K442	h1_on	0	1.38	No	No	No	No	3	3
445	8x56	8x57	h1_on	0	1.25	No	No	No	No	6	8
446	4x51	4x55	h1_on	0	1.22	No	No	No	No	5	5

Orange: nodes, hubs and links specific of h1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of h1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	h1_off Avg Int. Strength	h1_on Avg Int. Strength	h1_off Num Of Links	h1_on Num Of Links	ConSurf
1	I1x50	h1_off	3.90375	6.4	4	2	9
2	2x56	h1_off	6.06938	7.13667	4	3	9
3	I2x52	h1_off	4.24312	10.5267	4	3	5
4	E2.W165	h1_off	5.05071	3.84667	7	3	9
5	6x31	h1_off	2.71688	0	4	0	7
6	7x34	h1_off	5.5625	6.63	4	1	7
7	7x45	h1_off	6.6975	10.25	4	3	9
8	2x42	Shared	5.47571	6.37333	7	6	8
9	2x57	Shared	4.05625	5.13333	6	6	9
10	E1x50	Shared	4.67042	7.94375	6	8	9
11	3x33	Shared	9.35312	9.47	4	5	9
12	3x37	Shared	6.005	6.994	4	5	9
13	3x51	Shared	6.86687	9.4575	4	4	9
14	I2x56	Shared	4.13812	10.2075	4	4	8
15	4x57	Shared	6.7715	9.105	5	4	8
16	5x39	Shared	5.797	4.192	5	5	9
17	5x47	Shared	10.9906	11.398	4	5	9
18	5x54	Shared	5.19	5.87	4	4	9
19	5x58	Shared	3.335	5.9475	4	4	9
20	6x44	Shared	5.99687	6.1375	4	4	9
21	6x48	Shared	8.58875	7.45167	4	6	9
22	6x51	Shared	6.98321	8.472	7	5	9
23	6x52	Shared	12.9587	9.53667	4	6	9
24	7x38	Shared	4.75813	6.348	4	5	8
25	7x39	Shared	7.65958	4.99	6	7	9
26	7x42	Shared	5.98917	6.95375	6	8	9
27	8x54	Shared	5.29313	4.465	4	4	9
28	Lig	Shared	9.12346	10.625	13	8	0
29	1x46	h1_on	7.19	6.295	2	4	9
30	2x38	h1_on	4.84625	3.4	2	4	9
31	2x46	h1_on	4.51917	6.1	3	4	9
32	2x50	h1_on	7.20083	7.556	3	5	9
33	2x59	h1_on	6.5325	7.235	2	4	8
34	2x60	h1_on	8.475	8.35	1	4	8
35	3x28	h1_on	5.99417	9.5	3	5	9
36	3x29	h1_on	2.38	4.51	1	4	9
37	3x32	h1_on	8.44417	10.3	3	4	9
38	3x45	h1_on	7.09	3.9375	2	4	8
39	4x50	h1_on	6.2	4.794	2	5	9
40	4x53	h1_on	5.6	2.9875	1	4	9
41	E2.F168	h1_on	1.245	6.4225	1	4	0
42	E2.Q171	h1_on	3.0125	9.0675	1	4	0
43	E2.V174	h1_on	3.27	7.34	1	4	0
44	E2x50	h1_on	4.8525	6.315	3	4	9
45	E2x51	h1_on	9.61125	5.56	2	4	7
46	E2.F184	h1_on	10.2633	5.7225	3	4	9
47	5x461	h1_on	7.5525	7.7475	3	4	9
48	5x57	h1_on	6.82583	7.8425	3	4	7
49	5x62	h1_on	4.865	3.025	2	4	8
50	6x29	h1_on	0.62	8.885	1	4	8
51	7x53	h1_on	6.39417	5.554	3	5	9
52	8x50	h1_on	5.94167	5.055	3	4	9

Orange: nodes, hubs and links specific of h1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of h1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	h1_off Recurrence	h1_on Recurrence	h1_off Hub1?	h1_on Hub1?	h1_off Hub2?	h1_on Hub2?	ConSurf1	ConSurf2
1	2x56	7x42	h1_off	48.8266	1.55184	Yes	No	Yes	Yes	9	9
2	2x53	2x56	h1_off	44.2817	1.31194	No	No	Yes	No	9	9
3	1x50	7x50	h1_off	13.5538	6.94205	No	No	No	No	9	9
4	1x49	7x50	h1_off	11.3104	4.64053	No	No	No	No	9	9
5	3x40	Lig	h1_off	71.4507	0	No	No	Yes	Yes	9	0
6	3x40	6x44	h1_off	70.2353	3.17865	No	No	Yes	Yes	9	9
7	6x44	7x45	h1_off	100	0	Yes	Yes	Yes	No	9	9
8	2x43	7x53	h1_off	59.1932	0	No	No	No	Yes	9	9
9	2x40	2x43	h1_off	57.6901	0	No	No	No	No	9	9
10	6x48	Lig	h1_off	70.0866	0	Yes	Yes	Yes	Yes	9	0
11	6x44	6x48	h1_off	83.2461	0	Yes	Yes	Yes	Yes	9	9
12	1x53	8x54	h1_off	12.0378	0	No	No	Yes	Yes	9	9
13	1x60	I1x50	h1_off	15.1151	0	No	No	Yes	No	8	9
14	1x60	8x53	h1_off	11.7274	0	No	No	No	No	8	8
15	2x46	3x42	h1_off	37.1994	0	No	Yes	No	No	9	8
16	2x45	3x42	h1_off	35.5993	5.03786	No	No	No	No	9	8
17	2x42	3x49	h1_off	12.4903	5.26276	Yes	Yes	No	No	8	9
18	3x49	I2x57	h1_off	11.0906	0	No	No	No	No	9	9
19	2x53	3x35	h1_off	11.3104	0	No	No	No	No	9	8
20	2x56	3x28	h1_off	49.4214	0	Yes	No	No	Yes	9	9
21	2x63	E1x50	h1_off	23.0347	0.217408	No	No	Yes	Yes	7	9
22	E1x50	E1x52	h1_off	10.609	9.91079	Yes	Yes	No	No	9	9
23	3x33	4x61	h1_off	17.6881	3.11867	Yes	Yes	No	No	9	9
24	3x30	4x61	h1_off	16.5535	0	No	No	No	No	9	9
25	3x30	4x62	h1_off	11.0034	0	No	No	No	No	9	7
26	3x37	3x41	h1_off	10.7933	1.31944	Yes	Yes	No	No	9	8
27	3x43	6x44	h1_off	72.4593	0	No	No	Yes	Yes	9	9
28	3x44	3x48	h1_off	52.2369	0	No	No	No	No	8	6
29	3x48	5x57	h1_off	32.6674	2.92376	No	No	No	Yes	6	7
30	5x54	6x41	h1_off	14.8242	0	Yes	Yes	No	No	9	9
31	5x58	6x41	h1_off	11.4268	9.48347	Yes	Yes	No	No	9	9
32	3x48	3x52	h1_off	19.5242	0	No	No	No	No	6	8
33	3x52	I2x52	h1_off	16.4856	2.03913	No	No	Yes	No	8	5
34	5x43	Lig	h1_off	18.4057	0	No	No	Yes	Yes	8	0
35	2x63	E2.K179	h1_off	21.1533	0	No	No	No	No	7	4
36	E2.K179	E2.R176	h1_off	19.2656	0	No	No	No	No	4	1
37	5x45	5x48	h1_off	15.9394	0	No	No	No	No	7	8
38	3x51	5x61	h1_off	22.8536	8.74129	Yes	Yes	No	No	9	9
39	3x54	5x61	h1_off	21.1954	5.83252	No	No	No	No	9	9
40	3x54	5x64	h1_off	19.5306	2.91626	No	No	No	No	9	6
41	5x64	5x67	h1_off	17.8595	0	No	No	No	No	6	5
42	5x67	5x68	h1_off	14.4977	0	No	No	No	No	5	8
43	8x47	8x50	h1_off	12.041	0	No	No	No	Yes	9	9
44	6x36	8x47	h1_off	10.3375	0	No	No	No	No	9	9
45	5x47	6x49	h1_off	12.4418	0	Yes	Yes	No	No	9	8
46	5x41	5x45	h1_off	14.1938	3.17865	No	No	No	No	8	7
47	5x41	6x59	h1_off	12.4418	0	No	No	No	No	8	8
48	7x54	8x54	h1_off	10.0239	0	No	No	Yes	Yes	9	9
49	5x68	6x31	h1_off	12.8039	0	No	No	Yes	No	8	7
50	2x56	3x32	h1_off	43.8001	2.30902	Yes	No	No	Yes	9	9
51	3x32	Lig	h1_off	44.7149	2.40648	No	Yes	Yes	Yes	9	0
52	6x48	6x51	h1_off	13.8867	0	Yes	Yes	Yes	Yes	9	9
53	7x39	7x42	Shared	17.8433	12.2798	Yes	Yes	Yes	Yes	9	9
54	2x53	7x46	Shared	31.2678	52.5602	No	No	No	No	9	9
55	2x50	7x46	Shared	29.0762	52.3203	No	Yes	No	No	9	9
56	1x50	2x50	Shared	22.4625	75.1631	No	No	No	Yes	9	9
57	7x42	Lig	Shared	68.7516	84.594	Yes	Yes	Yes	Yes	9	0
58	7x45	7x49	Shared	96.0337	30.5495	Yes	No	No	No	9	9
59	2x46	7x49	Shared	94.6987	16.4855	No	Yes	No	No	9	9
60	2x46	7x53	Shared	61.8826	37.3041	No	Yes	No	Yes	9	9
61	2x40	I1x50	Shared	54.6515	28.1655	No	No	Yes	No	9	9
62	8x50	I1x50	Shared	37.7942	30.0247	No	Yes	Yes	No	9	9
63	8x50	8x54	Shared	24.8028	26.9436	No	Yes	Yes	Yes	9	9
64	1x53	2x47	Shared	10.3439	66.0169	No	No	No	No	9	9
65	2x45	4x46	Shared	30.7603	21.5758	No	No	No	No	9	9
66	2x42	4x46	Shared	22.5659	21.0585	Yes	Yes	No	No	8	9
67	3x28	E1x50	Shared	43.2829	20.7287	No	Yes	Yes	Yes	9	9
68	3x33	Lig	Shared	20.2256	68.3559	Yes	Yes	Yes	Yes	9	0
69	3x43	5x54	Shared	71.0144	27.9481	No	No	Yes	Yes	9	9
70	3x44	5x54	Shared	55.2883	15.0611	No	No	Yes	Yes	8	9
71	3x51	5x57	Shared	27.7314	25.834	Yes	Yes	No	Yes	9	7
72	5x39	5x43	Shared	17.9112	28.0756	Yes	Yes	No	No	9	8
73	6x52	Lig	Shared	31.0738	80.7482	Yes	Yes	Yes	Yes	9	0
74	5x47	6x52	Shared	38.0431	100	Yes	Yes	Yes	Yes	9	9
75	5x47	5x48	Shared	19.411	28.4729	Yes	Yes	No	No	9	8
76	2x57	7x42	Shared	10.7318	42.0571	Yes	Yes	Yes	Yes	9	9
77	6x51	6x52	Shared	10.0821	51.0533	Yes	Yes	Yes	Yes	9	9
78	1x43	2x57	h1_on	2.53103	11.3952	No	No	Yes	Yes	9	9
79	2x53	7x42	h1_on	0	51.7205	No	No	Yes	Yes	9	9
80	1x47	2x54	h1_on	2.53103	18.3447	No	No	No	No	6	9
81	1x47	1x51	h1_on	0	13.8466	No	No	No	No	6	8
82	1x50	2x47	h1_on	0	67.9061	No	No	No	No	9	9
83	1x53	7x54	h1_on	0	64.1128	No	No	No	No	9	9
84	7x54	8x50	h1_on	0	60.5218	No	No	No	Yes	9	9
85	3x37	Lig	h1_on	0	45.9705	Yes	Yes	Yes	Yes	9	0
86	3x37	4x53	h1_on	2.70559	56.1511	Yes	Yes	No	Yes	9	9
87	4x50	4x53	h1_on	0	35.8348	No	Yes	No	Yes	9	9
88	2x52	4x50	h1_on	0	15.9157	No	No	No	Yes	8	9
89	2x48	2x52	h1_on	0	10.593	No	No	No	No	6	8
90	8x53	8x54	h1_on	0	15.9982	No	No	Yes	Yes	8	9
91	1x56	8x53	h1_on	1.73907	13.7567	No	No	No	No	9	8
92	1x56	8x57	h1_on	0	11.5001	No	No	No	No	9	8
93	2x37	2x40	h1_on	1.73907	26.1789	No	No	No	No	9	9
94	2x37	2x38	h1_on	0	24.0123	No	No	No	Yes	9	9
95	2x38	I2x57	h1_on	8.00362	15.181	No	Yes	No	No	9	9
96	2x46	2x50	h1_on	0	37.739	No	Yes	No	Yes	9	9
97	3x46	7x53	h1_on	0	27.2059	No	No	No	Yes	9	9
98	2x42	3x46	h1_on	1.72291	25.7516	Yes	Yes	No	No	8	9
99	2x45	4x50	h1_on	3.47492	27.3559	No	No	No	Yes	9	9
100	2x46	3x43	h1_on	0	14.6863	No	Yes	No	No	9	9
101	2x50	7x49	h1_on	0	13.3518	No	Yes	No	No	9	9
102	1x51	2x51	h1_on	4.54163	11.5751	No	No	No	No	8	8
103	2x60	3x28	h1_on	0	35.7448	No	Yes	No	Yes	8	9
104	2x60	7x42	h1_on	0	25.6241	No	Yes	Yes	Yes	8	9
105	3x33	E2.F184	h1_on	0	84.6765	Yes	Yes	No	Yes	9	9
106	E2.F168	E2.F184	h1_on	0	93.5003	No	Yes	No	Yes	0	9
107	E2.F168	E2.Q170	h1_on	0	74.6833	No	Yes	No	No	0	0
108	E2.Q170	E2.Q171	h1_on	0	71.9844	No	No	No	Yes	0	0
109	E2.Q171	E2.V174	h1_on	0	34.6953	No	Yes	No	Yes	0	0
110	E2.V174	E2x51	h1_on	0	26.0814	No	Yes	No	Yes	0	7
111	3x22	E2x51	h1_on	0	46.4653	No	No	No	Yes	5	7
112	E2.Q171	E2.Y185	h1_on	0	28.8402	No	Yes	No	No	0	7
113	E2.Y185	E2x51	h1_on	6.15464	26.1564	No	No	No	Yes	7	7
114	3x22	E2.D183	h1_on	0	35.205	No	No	No	No	5	7
115	3x28	3x29	h1_on	0	10.3606	No	Yes	No	Yes	9	9
116	3x34	4x53	h1_on	0	24.5821	No	No	No	Yes	9	9
117	3x30	3x34	h1_on	0	10.0082	No	No	No	No	9	9
118	3x29	E2x52	h1_on	0	14.3489	No	Yes	No	No	9	9
119	E2.F184	E2x52	h1_on	1.92009	16.0357	No	Yes	No	No	9	9
120	3x36	Lig	h1_on	1.43199	11.9124	No	No	Yes	Yes	9	0
121	3x33	4x57	h1_on	0.659426	17.9774	Yes	Yes	Yes	Yes	9	8
122	3x37	4x57	h1_on	8.37536	29.7399	Yes	Yes	Yes	Yes	9	8
123	6x51	7x38	h1_on	0.924489	20.7962	Yes	Yes	Yes	Yes	9	8
124	3x36	6x48	h1_on	0	16.0657	No	No	Yes	Yes	9	9
125	6x48	6x52	h1_on	0	31.2017	Yes	Yes	Yes	Yes	9	9
126	5x47	6x44	h1_on	0	83.7094	Yes	Yes	Yes	Yes	9	9
127	5x54	6x44	h1_on	0	86.0559	Yes	Yes	Yes	Yes	9	9
128	3x46	3x50	h1_on	0	15.391	No	No	No	No	9	9
129	3x47	5x54	h1_on	1.73907	73.9636	No	No	Yes	Yes	8	9
130	3x47	5x57	h1_on	0	34.178	No	No	No	Yes	8	7
131	3x47	5x58	h1_on	0	45.3632	No	No	Yes	Yes	8	9
132	3x51	3x55	h1_on	1.73907	11.5976	Yes	Yes	No	No	9	8
133	I2x52	I2x57	h1_on	0	13.2169	Yes	No	No	No	5	9
134	2x42	4x42	h1_on	1.72938	13.4868	Yes	Yes	No	No	8	9
135	2x41	4x42	h1_on	0	10.8179	No	No	No	No	8	9
136	3x34	4x54	h1_on	1.44492	12.4747	No	No	No	No	9	5
137	4x51	4x54	h1_on	0	10.0082	No	No	No	No	5	5
138	4x57	5x43	h1_on	0.627101	32.3562	Yes	Yes	No	No	8	8
139	4x60	5x39	h1_on	2.77024	14.3414	No	No	Yes	Yes	9	9
140	5x39	E2.F168	h1_on	0	16.3955	Yes	Yes	No	Yes	9	0
141	E2.D183	E2.W165	h1_on	1.18309	29.38	No	No	Yes	No	7	9
142	E2.N166	E2.W165	h1_on	1.41259	17.67	No	No	Yes	No	6	9
143	6x52	6x55	h1_on	0	54.7417	Yes	Yes	No	No	9	8
144	5x40	6x55	h1_on	1.59361	51.8105	No	No	No	No	9	8
145	5x40	6x58	h1_on	0	33.9006	No	No	No	No	9	6
146	6x58	7x30	h1_on	0	25.0618	No	No	No	No	6	6
147	5x40	6x59	h1_on	0	15.7733	No	No	No	No	9	8
148	5x48	6x53	h1_on	0	20.1289	No	No	No	No	8	7
149	5x58	6x37	h1_on	4.57073	42.327	Yes	Yes	No	No	9	9
150	5x62	6x37	h1_on	0	39.3058	No	Yes	No	No	8	9
151	5x62	5x66	h1_on	1.73907	30.8944	No	Yes	No	No	8	7
152	5x66	6x30	h1_on	0	24.687	No	No	No	No	7	8
153	6x29	6x30	h1_on	0	22.0031	No	Yes	No	No	8	8
154	6x25	6x29	h1_on	0	12.6771	No	No	No	Yes	5	8
155	6x40	7x53	h1_on	1.72291	12.3173	No	No	No	Yes	9	9
156	7x52	7x53	h1_on	0	12.6471	No	No	No	Yes	9	9
157	6x49	6x53	h1_on	1.79403	17.3551	No	No	No	No	8	7
158	6x48	7x45	h1_on	0	42.6944	Yes	Yes	Yes	No	9	9
159	6x47	7x45	h1_on	1.73907	14.6113	No	No	Yes	No	9	9
160	7x30	E3.C444	h1_on	0	12.6471	No	No	No	No	6	5
161	5x39	5x42	h1_on	0	14.9411	Yes	Yes	No	No	9	7
162	2x54	2x57	h1_on	3.78847	20.3014	No	No	Yes	Yes	9	9
163	3x33	6x51	h1_on	0	37.7839	Yes	Yes	Yes	Yes	9	9
164	5x461	6x52	h1_on	0	18.9744	No	Yes	Yes	Yes	9	9
165	3x50	5x58	h1_on	0	15.226	No	No	Yes	Yes	9	9
166	3x43	7x53	h1_on	0	12.7071	No	No	No	Yes	9	9
167	3x37	5x461	h1_on	7.77411	17.4901	Yes	Yes	No	Yes	9	9
168	4x57	E2.F184	h1_on	0	10.3531	Yes	Yes	No	Yes	8	9
169	2x60	7x38	h1_on	0	11.1103	No	Yes	Yes	Yes	8	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	7.665	13.15	1	1	2	1
2x56	7x42	Shared	7.8875	5.05	1	1	2	1
2x57	7x39	Shared	5.235	4.65	1	1	2	2
2x57	7x42	Shared	5.0875	3.59	1	1	2	1
2x60	7x39	Shared	8.475	3.39	0	1	2	2
3x32	7x42	Shared	6.0375	13.79	1	1	1	1
3x32	Lig	Shared	11.63	9.84	1	1	1	0
3x33	4x57	Shared	8.2	15.43	1	1	1	1
3x33	E2x52	h1_off	4.0575	0	1	1	1	2
3x33	Lig	Shared	20.925	19.12	1	1	1	0
3x36	Lig	Shared	9.5325	6.8	0	1	1	0
3x37	3x41	Shared	4.865	6.49	1	1	1	2
3x37	4x53	Shared	5.6	3.2	1	1	1	2
3x37	4x57	Shared	6.975	9.7	1	1	1	1
3x37	5x461	Shared	6.58	10.24	1	1	1	1
3x40	5x50	h1_off	6.3475	0	0	0	1	2
3x40	6x44	Shared	6.5925	3.77	0	0	1	2
3x40	Lig	h1_off	4.4425	0	0	0	1	0
4x57	5x43	Shared	7.885	7.28	1	1	1	1
4x57	5x461	h1_off	6.78	0	1	1	1	1
4x57	Lig	h1_off	4.0175	0	1	1	1	0
E2.F184	E2x52	Shared	12.9675	5.19	1	1	2	2
5x39	E2.F184	h1_off	12.0575	0	1	0	2	2
5x39	5x43	Shared	3.5675	7.78	1	0	2	1
5x40	6x55	Shared	8.3775	17.37	0	0	2	1
5x43	Lig	h1_off	3.8225	0	1	0	1	0
5x461	Lig	Shared	9.2975	7.46	1	1	1	0
5x47	6x52	Shared	30.545	23.58	0	1	2	1
6x44	6x48	h1_off	6.265	0	0	1	2	1
6x44	7x45	h1_off	7.8525	0	0	1	2	2
6x48	6x51	h1_off	5.7875	0	1	1	1	1
6x48	7x41	Shared	9.8525	8.44	1	1	1	2
6x48	Lig	h1_off	12.45	0	1	1	1	0
6x51	6x52	Shared	3.35	6.19	1	1	1	1
6x51	6x55	h1_off	9.0275	0	1	1	1	1
6x51	7x37	Shared	6.8675	4.99	1	1	1	2
6x51	7x38	Shared	5.14	4.84	1	1	1	1
6x51	Lig	Shared	12.45	23.36	1	1	1	0
6x52	Lig	Shared	15.515	8.83	1	1	1	0
6x55	Lig	h1_off	6.795	0	1	0	1	0
7x38	7x42	Shared	4.8375	9.67	1	1	1	1
7x38	Lig	h1_off	4.085	0	1	1	1	0
7x39	7x42	Shared	8.4425	3.86	1	1	2	1
7x42	Lig	Shared	3.6425	4.25	1	1	1	0
3x33	4x61	Shared	4.23	3.63	1	1	1	2
6x51	7x34	h1_off	6.26	0	1	1	1	2
7x34	7x38	Shared	4.97	6.63	1	0	2	1
2x53	2x56	Shared	3.2075	3.21	0	1	2	2
5x44	6x52	h1_off	2.425	0	0	0	2	1
2x53	7x42	h1_on	0	3.79	0	1	2	1
2x60	7x38	h1_on	0	7.08	0	1	2	1
2x60	7x42	h1_on	0	11.63	0	1	2	1
3x32	3x36	h1_on	0	4.42	1	1	1	1
3x33	E2.F184	h1_on	0	6.19	1	1	1	2
3x33	6x51	h1_on	0	2.98	1	1	1	1
3x36	6x48	h1_on	0	4.94	0	1	1	1
3x37	Lig	h1_on	0	5.34	1	1	1	0
3x40	6x48	h1_on	0	15.27	0	0	1	1
3x41	5x461	h1_on	0	7.25	0	1	2	1
4x57	E2.F184	h1_on	0	4.01	1	1	1	2
5x461	6x52	h1_on	0	6.04	1	1	1	1
5x47	6x44	h1_on	0	4.29	0	1	2	2
5x47	6x48	h1_on	0	3.01	0	1	2	1
6x48	6x52	h1_on	0	4.01	1	1	1	1
6x48	7x45	h1_on	0	9.04	1	1	1	2
6x52	6x55	h1_on	0	8.57	1	1	1	1
7x38	7x39	h1_on	0	3.52	1	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	h1_off	3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole 8X63-H₁-Mepyramine 8X64-H₁-Desloratadine
	h1_on	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2

Network Difference
Value	h1_off	h1_on
I_min	3.2675	2.94
Number of Linked Nodes	275	251
Number of Specific Nodes	30 (10.91%)	6 (2.39%)
Number of Shared Nodes	245 (89.09%)	245 (97.61%)
Number of Links	292	299
Number of Specific Links	147 (50.34%)	154 (51.51%)
Number of Shared Links	145 (49.66%)	145 (48.50%)
Number of Hubs	28	45
Number of Specific Hubs	7 (25.00%)	24 (53.33%)
Number of Shared Hubs	21 (75.00%)	21 (46.67%)
Average % Shared Neighbours (Jaccard)	31.37
Average % Shared Neighbours (Otsuka)	41.97
Average % Shared Neighbours (Overlap Coefficient)	52.71
Average % Shared Cliques (k3-6)	53.26
Graphlets Similarity	0.604362

Paths Difference
Value	h1_off	h1_on
Number Of Nodes in MetaPath	76	103
Specific Nodes in MetaPath	30 (39.47%)	57 (55.34%)
Shared Nodes in MetaPath	245 (89.09%)	245 (89.09%)
Number Of Links MetaPath	77	117
Specific Links in MetaPath	52 (67.53%)	92 (78.63%)
Shared Links in MetaPath	145 (49.66%)	145 (49.66%)
Number of Shortest Paths	70216	51809
Length Of Smallest Path	3	3
Average Path Length	14.5878	12.4035
Length of Longest Path	30	31
Minimum Path Strength	0.58125	1.365
Average Path Strength	5.98666	6.66047
Maximum Path Strength	23.03	19.01
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.910628	0.922359
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.7037	4.16667
Average % Of Corr. Nodes	43.2703	54.633
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	38.0965	51.451
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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