psnGPCR

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Orange: nodes, hubs and links specific of histamine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of histamine_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	histamine_off Int. Strength	histamine_on Int. Strength	histamine_off Hub1?	histamine_on Hub1?	histamine_off Hub2?	histamine_on Hub2?	ConSurf1	ConSurf2
1	1x40	2x61	histamine_off	100	0	No	No	No	No	7	8
2	1x49	7x50	histamine_off	100	0	No	No	No	No	9	9
3	1x51	2x51	histamine_off	100	0	No	No	No	No	8	8
4	1x53	8x54	histamine_off	100	0	No	No	Yes	Yes	9	9
5	1x54	2x47	histamine_off	100	0	No	No	No	No	8	9
6	1x54	2x48	histamine_off	100	0	No	No	No	No	8	6
7	1x58	2x44	histamine_off	100	0	No	No	No	No	6	8
8	1x60	I1x49	histamine_off	100	0	No	No	No	No	8	7
9	1x60	8x53	histamine_off	100	0	No	No	No	No	8	8
10	I1x48	I1x51	histamine_off	100	0	No	No	No	No	8	8
11	2x40	I1x50	histamine_off	100	0	No	No	Yes	No	9	9
12	2x40	2x43	histamine_off	100	0	No	No	No	Yes	9	9
13	2x42	4x42	histamine_off	100	0	Yes	Yes	No	No	8	9
14	2x43	7x53	histamine_off	100	0	No	Yes	No	No	9	9
15	2x46	3x42	histamine_off	100	0	No	No	No	No	9	8
16	2x46	7x53	histamine_off	100	0	No	No	No	No	9	9
17	2x56	3x28	histamine_off	100	0	Yes	No	No	Yes	9	9
18	2x60	7x39	histamine_off	100	0	No	Yes	Yes	No	8	9
19	3x22	3x26	histamine_off	100	0	No	No	No	No	5	8
20	3x30	4x61	histamine_off	100	0	No	No	No	No	9	9
21	3x34	4x54	histamine_off	100	0	No	No	No	No	9	5
22	3x37	3x41	histamine_off	100	0	Yes	No	No	No	9	8
23	3x40	5x50	histamine_off	100	0	No	No	No	No	9	9
24	3x40	Lig	histamine_off	100	0	No	No	Yes	Yes	9	0
25	3x43	5x54	histamine_off	100	0	No	No	Yes	No	9	9
26	3x44	3x48	histamine_off	100	0	No	No	No	No	8	6
27	3x45	4x45	histamine_off	100	0	No	No	No	No	8	8
28	3x49	I2x57	histamine_off	100	0	No	No	No	No	9	9
29	3x50	6x33	histamine_off	100	0	No	No	No	No	9	9
30	3x50	6x37	histamine_off	100	0	No	No	No	No	9	9
31	3x53	I2x57	histamine_off	100	0	No	No	No	No	9	9
32	3x56	I2x52	histamine_off	100	0	No	No	Yes	No	7	5
33	4x57	5x461	histamine_off	100	0	Yes	Yes	No	No	8	9
34	4x57	Lig	histamine_off	100	0	Yes	Yes	Yes	Yes	8	0
35	5x38	5x39	histamine_off	100	0	No	No	Yes	Yes	5	9
36	5x43	Lig	histamine_off	100	0	No	No	Yes	Yes	8	0
37	5x54	6x41	histamine_off	100	0	Yes	No	No	No	9	9
38	5x58	6x38	histamine_off	100	0	Yes	No	No	No	9	8
39	5x68	6x31	histamine_off	100	0	No	No	Yes	No	8	7
40	6x36	8x47	histamine_off	100	0	No	No	No	No	9	9
41	6x39	7x56	histamine_off	100	0	No	No	No	No	7	9
42	6x43	7x45	histamine_off	100	0	No	No	Yes	No	8	9
43	6x44	7x45	histamine_off	100	0	Yes	Yes	Yes	No	9	9
44	6x48	6x51	histamine_off	100	0	Yes	Yes	Yes	Yes	9	9
45	6x51	6x52	histamine_off	100	0	Yes	Yes	Yes	Yes	9	9
46	6x51	6x55	histamine_off	100	0	Yes	Yes	No	No	9	8
47	6x54	7x34	histamine_off	100	0	No	No	Yes	No	7	7
48	6x55	Lig	histamine_off	100	0	No	No	Yes	Yes	8	0
49	7x31	7x34	histamine_off	100	0	No	No	Yes	No	4	7
50	7x35	7x39	histamine_off	100	0	No	No	Yes	No	6	9
51	7x54	8x54	histamine_off	100	0	No	No	Yes	Yes	9	9
52	8x47	8x50	histamine_off	100	0	No	No	No	No	9	9
53	NT	NT	histamine_off	100	0	Yes	No	Yes	No	5	5
54	1x49	7x51	histamine_off	100	0	No	No	No	No	9	7
55	2x63	E2	histamine_off	100	0	No	No	Yes	Yes	7	5
56	3x33	4x61	histamine_off	100	0	Yes	Yes	No	No	9	9
57	3x52	I2x53	histamine_off	100	0	No	No	No	No	8	9
58	3x56	I2x51	histamine_off	100	0	No	No	No	No	7	8
59	5x48	6x56	histamine_off	100	0	No	Yes	No	No	8	7
60	1x43	2x58	histamine_off	50	0	No	No	No	No	9	9
61	E2	E3	histamine_off	25	0	Yes	Yes	Yes	No	5	4
62	3x43	6x44	histamine_off	50	0	No	No	Yes	Yes	9	9
63	2x39	2x42	histamine_off	50	0	No	No	Yes	Yes	8	8
64	6x35	7x56	histamine_off	75	0	No	No	No	No	7	9
65	2x53	2x56	histamine_off	50	0	No	No	Yes	No	9	9
66	2x59	3x24	histamine_off	50	0	No	No	No	No	8	7
67	2x41	4x39	histamine_off	50	0	No	No	No	No	8	8
68	6x39	7x55	histamine_off	50	0	No	No	No	No	7	8
69	5x51	6x45	histamine_off	75	0	No	No	No	No	9	8
70	2x42	4x46	histamine_off	50	0	Yes	Yes	No	No	8	9
71	5x65	6x31	histamine_off	50	0	No	No	Yes	No	9	7
72	1x56	8x53	histamine_off	25	0	No	No	No	No	9	8
73	5x65	6x30	histamine_off	25	0	No	No	No	No	9	8
74	6x58	E3	histamine_off	50	0	No	No	Yes	No	6	4
75	6x25	6x31	histamine_off	25	0	No	No	Yes	No	5	7
76	6x27	6x30	histamine_off	25	0	No	No	No	No	3	8
77	5x69	6x30	histamine_off	25	0	No	No	No	No	5	8
78	2x61	7x39	histamine_off	50	0	No	No	Yes	No	8	9
79	5x67	5x68	histamine_off	50	0	No	No	No	No	5	8
80	3x30	4x62	histamine_off	50	0	No	No	No	No	9	7
81	2x49	3x39	histamine_off	25	0	No	No	No	No	9	9
82	7x30	7x32	histamine_off	25	0	No	No	No	No	6	2
83	3x22	3x23	histamine_off	50	0	No	No	No	No	5	5
84	4x38	I2x56	histamine_off	25	0	No	No	Yes	Yes	9	8
85	3x34	4x58	histamine_off	25	0	No	No	No	No	9	5
86	1x60	I1x50	histamine_off	25	0	No	No	Yes	No	8	9
87	5x41	5x45	histamine_off	50	0	No	No	No	No	8	7
88	2x52	3x31	histamine_off	25	0	No	No	No	No	8	8
89	5x46	5x49	histamine_off	50	0	No	No	No	No	5	7
90	5x64	5x67	histamine_off	50	0	No	No	No	No	6	5
91	8x49	I1x50	histamine_off	0	0	No	No	Yes	No	9	9
92	1x55	8x56	histamine_off	25	0	No	No	No	No	5	6
93	6x28	6x31	histamine_off	25	0	No	No	Yes	No	7	7
94	2x65	NT	histamine_off	25	0	No	Yes	Yes	No	6	5
95	3x41	4x49	histamine_off	25	0	No	No	No	No	8	7
96	5x41	6x59	histamine_off	0	0	No	No	No	No	8	8
97	5x65	6x34	histamine_off	0	0	No	No	No	No	9	9
98	6x32	8x48	histamine_off	25	0	No	No	No	No	9	5
99	8x48	8x51	histamine_off	25	0	No	No	No	No	5	8
100	8x53	8x56	histamine_off	25	0	No	No	No	No	8	6
101	2x44	2x47	histamine_off	25	0	No	No	No	No	8	9
102	4x43	4x46	histamine_off	25	0	No	No	No	No	6	9
103	I2x52	I2x54	histamine_off	25	0	Yes	No	No	No	5	8
104	4x48	4x51	histamine_off	0	0	No	No	No	No	5	5
105	6x49	6x53	histamine_off	25	0	No	No	No	No	8	7
106	1x42	2x57	histamine_off	25	0	No	No	Yes	Yes	7	9
107	2x62	2x66	histamine_off	25	0	No	No	No	No	6	5
108	1x35	1x39	histamine_off	25	0	No	No	No	No	9	8
109	1x47	2x54	histamine_off	0	0	No	No	No	No	6	9
110	1x36	1x37	histamine_off	0	0	No	No	No	No	7	4
111	1x36	2x61	histamine_off	0	0	No	No	No	No	7	8
112	4x43	4x47	histamine_off	25	0	No	No	No	No	6	7
113	1x35	1x38	histamine_off	25	0	No	No	No	No	9	4
114	E1	E2	histamine_off	25	0	No	No	Yes	Yes	3	5
115	7x40	7x43	histamine_off	0	0	No	No	No	No	9	6
116	4x52	4x55	histamine_off	0	0	No	No	No	No	7	5
117	5x38	5x42	histamine_off	25	0	No	No	No	No	5	7
118	1x48	1x51	histamine_off	0	0	No	No	No	No	6	8
119	7x54	8x51	histamine_off	0	0	No	No	No	No	9	8
120	1x41	1x45	histamine_off	0	0	No	No	No	No	5	4
121	5x51	5x52	histamine_off	0	0	No	No	No	No	9	5
122	8x51	8x55	histamine_off	0	0	No	No	No	No	8	8
123	8x58	8x59	histamine_off	0	0	No	No	No	No	8	6
124	6x29	6x32	histamine_off	0	0	No	Yes	No	No	8	9
125	5x58	5x62	histamine_off	0	0	Yes	No	No	No	9	8
126	1x41	1x44	histamine_off	0	0	No	No	No	No	5	7
127	5x63	5x67	histamine_off	0	0	No	No	No	No	6	5
128	1x36	2x65	Shared	100	0	No	No	No	Yes	7	6
129	1x39	7x39	Shared	100	100	No	No	Yes	No	8	9
130	1x43	2x57	Shared	100	100	No	No	Yes	Yes	9	9
131	1x46	2x57	Shared	100	100	No	No	Yes	Yes	9	9
132	1x46	7x47	Shared	100	100	No	No	No	No	9	9
133	1x50	2x50	Shared	100	100	No	No	No	Yes	9	9
134	1x50	2x51	Shared	100	100	No	No	No	No	9	8
135	1x50	7x50	Shared	100	100	No	No	No	No	9	9
136	1x52	8x54	Shared	100	100	No	Yes	Yes	Yes	9	9
137	1x53	2x47	Shared	100	100	No	No	No	No	9	9
138	1x57	2x44	Shared	100	100	No	No	No	No	8	8
139	8x50	I1x50	Shared	100	100	No	No	Yes	No	9	9
140	2x37	2x40	Shared	100	100	No	No	No	No	9	9
141	2x38	I2x57	Shared	100	100	No	Yes	No	No	9	9
142	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	8
143	2x42	3x46	Shared	100	100	Yes	Yes	No	Yes	8	9
144	2x42	3x49	Shared	100	100	Yes	Yes	No	No	8	9
145	2x42	4x45	Shared	100	100	Yes	Yes	No	No	8	8
146	2x45	3x42	Shared	100	100	No	No	No	No	9	8
147	2x45	4x50	Shared	100	100	No	No	No	Yes	9	9
148	2x46	7x49	Shared	100	100	No	No	No	Yes	9	9
149	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
150	2x53	7x46	Shared	100	100	No	No	No	No	9	9
151	2x54	2x57	Shared	100	100	No	No	Yes	Yes	9	9
152	2x551	3x31	Shared	100	100	No	No	No	No	6	8
153	2x56	3x32	Shared	100	100	Yes	No	No	Yes	9	9
154	2x56	7x42	Shared	100	100	Yes	No	Yes	Yes	9	9
155	2x57	7x39	Shared	100	100	Yes	Yes	Yes	No	9	9
156	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	9	9
157	2x59	3x28	Shared	100	100	No	No	No	Yes	8	9
158	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	7	9
159	2x64	7x35	Shared	100	0	No	No	No	No	8	6
160	E1x50	E1x52	Shared	100	100	Yes	Yes	No	Yes	9	9
161	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	9
162	3x22	E2	Shared	100	100	No	No	Yes	Yes	5	5
163	3x25	E2x50	Shared	100	100	No	No	No	Yes	9	9
164	3x27	3x31	Shared	100	100	No	No	No	No	8	8
165	3x30	4x58	Shared	100	50	No	No	No	No	9	5
166	3x32	7x42	Shared	100	100	No	Yes	Yes	Yes	9	9
167	3x32	Lig	Shared	100	100	No	Yes	Yes	Yes	9	0
168	3x33	4x57	Shared	100	100	Yes	Yes	Yes	Yes	9	8
169	3x33	E2x52	Shared	100	100	Yes	Yes	No	No	9	9
170	3x33	Lig	Shared	100	100	Yes	Yes	Yes	Yes	9	0
171	3x36	Lig	Shared	100	100	No	No	Yes	Yes	9	0
172	3x37	4x53	Shared	100	100	Yes	No	No	No	9	9
173	3x37	4x57	Shared	100	100	Yes	No	Yes	Yes	9	8
174	3x37	5x461	Shared	100	100	Yes	No	No	No	9	9
175	3x38	4x50	Shared	100	100	No	No	No	Yes	9	9
176	3x40	6x44	Shared	100	100	No	No	Yes	Yes	9	9
177	3x41	4x52	Shared	100	0	No	No	No	No	8	7
178	3x44	5x53	Shared	100	100	No	No	No	No	8	6
179	3x44	5x54	Shared	100	50	No	No	Yes	No	8	9
180	3x47	5x54	Shared	100	100	No	No	Yes	No	8	9
181	3x48	5x57	Shared	100	100	No	No	No	Yes	6	7
182	3x51	3x55	Shared	100	100	Yes	Yes	No	No	9	8
183	3x51	5x60	Shared	100	100	Yes	Yes	No	No	9	5
184	3x52	I2x52	Shared	100	100	No	No	Yes	No	8	5
185	I2x52	I2x56	Shared	100	100	Yes	No	Yes	Yes	5	8
186	4x41	I2x56	Shared	100	100	No	No	Yes	Yes	9	8
187	4x57	5x43	Shared	100	100	Yes	Yes	No	No	8	8
188	4x59	4x60	Shared	100	100	No	No	No	No	8	9
189	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	5	5
190	E2	E2x51	Shared	100	100	Yes	Yes	No	No	5	7
191	E2	E2x52	Shared	100	100	Yes	Yes	No	No	5	9
192	5x36	E2	Shared	100	100	No	No	Yes	Yes	8	5
193	5x39	E2	Shared	100	100	Yes	Yes	Yes	Yes	9	5
194	5x36	5x38	Shared	100	100	No	No	No	No	8	5
195	5x39	5x43	Shared	100	100	Yes	Yes	No	No	9	8
196	5x40	6x55	Shared	100	100	No	No	No	No	9	8
197	5x461	Lig	Shared	100	100	No	No	Yes	Yes	9	0
198	5x47	5x48	Shared	100	100	Yes	Yes	No	Yes	9	8
199	5x47	5x51	Shared	100	100	Yes	Yes	No	No	9	9
200	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	9	9
201	5x56	5x57	Shared	100	100	No	No	No	Yes	4	7
202	5x56	5x60	Shared	100	100	No	No	No	No	4	5
203	5x58	6x41	Shared	100	0	Yes	No	No	No	9	9
204	5x62	5x66	Shared	100	50	No	No	No	No	8	7
205	6x36	7x56	Shared	100	100	No	No	No	No	9	9
206	6x39	7x52	Shared	100	100	No	No	No	Yes	7	9
207	6x40	7x53	Shared	100	100	No	No	No	No	9	9
208	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	9
209	6x47	7x45	Shared	100	100	No	No	Yes	No	9	9
210	6x48	7x41	Shared	100	100	Yes	Yes	No	No	9	9
211	6x48	Lig	Shared	100	100	Yes	Yes	Yes	Yes	9	0
212	6x49	6x50	Shared	100	75	No	No	No	No	8	9
213	6x51	7x37	Shared	100	100	Yes	Yes	No	No	9	9
214	6x51	7x38	Shared	100	100	Yes	Yes	Yes	Yes	9	8
215	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	9	0
216	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	9	0
217	6x54	7x33	Shared	100	100	No	No	No	No	7	4
218	6x61	E3	Shared	100	100	No	No	Yes	No	7	4
219	7x38	7x42	Shared	100	100	Yes	Yes	Yes	Yes	8	9
220	7x38	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
221	7x39	7x42	Shared	100	100	Yes	No	Yes	Yes	9	9
222	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	9	0
223	7x45	7x49	Shared	100	100	Yes	No	No	Yes	9	9
224	8x50	8x54	Shared	100	100	No	No	Yes	Yes	9	9
225	2x45	4x46	Shared	100	100	No	No	No	No	9	9
226	E1x50	E2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
227	3x51	5x57	Shared	100	100	Yes	Yes	No	Yes	9	7
228	3x54	5x61	Shared	100	100	No	No	No	No	9	9
229	6x51	7x34	Shared	100	100	Yes	Yes	Yes	No	9	7
230	7x34	7x38	Shared	100	100	Yes	No	Yes	Yes	7	8
231	E1x49	E2	Shared	100	100	No	No	Yes	Yes	2	5
232	5x45	5x48	Shared	75	100	No	No	No	Yes	7	8
233	2x50	3x39	Shared	75	100	No	Yes	No	No	9	9
234	5x58	6x37	Shared	75	100	Yes	No	No	No	9	9
235	1x55	1x59	Shared	50	100	No	No	No	No	5	7
236	5x47	6x49	Shared	50	25	Yes	Yes	No	No	9	8
237	3x48	3x52	Shared	50	100	No	No	No	No	6	8
238	7x36	7x40	Shared	25	100	No	No	No	No	5	9
239	3x51	5x61	Shared	25	100	Yes	Yes	No	No	9	9
240	2x53	3x35	Shared	50	100	No	No	No	No	9	8
241	7x43	7x48	Shared	50	0	No	No	No	No	6	8
242	2x52	3x35	Shared	25	100	No	No	No	No	8	8
243	8x52	8x56	Shared	25	0	No	No	No	No	7	6
244	4x39	I1x51	Shared	25	100	No	No	No	No	8	8
245	6x50	7x40	Shared	50	50	No	No	No	No	9	9
246	4x47	4x51	Shared	25	0	No	No	No	No	7	5
247	5x44	6x52	Shared	25	50	No	No	Yes	Yes	9	9
248	3x29	E2x50	Shared	25	100	No	No	No	Yes	9	9
249	3x56	I2x50	Shared	25	100	No	No	No	No	7	9
250	4x38	4x40	Shared	25	50	No	No	No	No	9	6
251	1x45	1x49	Shared	25	50	No	No	No	No	4	9
252	1x34	NT	Shared	25	0	No	No	Yes	No	3	5
253	5x49	5x50	Shared	0	100	No	No	No	No	7	9
254	7x32	7x33	Shared	25	25	No	No	No	No	2	4
255	6x60	6x61	Shared	25	100	No	No	No	No	7	7
256	6x57	E3	Shared	25	0	No	No	Yes	No	8	4
257	3x54	5x64	Shared	0	0	No	No	No	No	9	6
258	4x63	E2	Shared	25	50	No	No	Yes	Yes	7	5
259	3x21	3x23	Shared	0	0	No	No	No	No	8	5
260	2x38	4x39	Shared	25	0	No	Yes	No	No	9	8
261	5x55	6x41	Shared	25	100	No	No	No	No	7	9
262	2x62	E1x52	Shared	25	100	No	No	No	Yes	6	9
263	1x47	2x55	Shared	0	50	No	No	No	No	6	7
264	I2x55	I2x56	Shared	25	50	No	No	Yes	Yes	5	8
265	4x60	5x39	Shared	0	50	No	No	Yes	Yes	9	9
266	5x37	6x59	Shared	25	100	No	Yes	No	No	8	8
267	2x66	E1x51	Shared	0	50	No	No	No	No	5	5
268	1x55	8x57	Shared	0	100	No	No	No	No	5	8
269	1x39	2x61	histamine_on	0	100	No	No	No	No	8	8
270	1x45	7x47	histamine_on	0	100	No	No	No	No	4	9
271	1x53	7x54	histamine_on	0	100	No	No	No	No	9	9
272	1x54	1x58	histamine_on	0	100	No	No	No	No	8	6
273	2x37	2x38	histamine_on	0	100	No	No	No	Yes	9	9
274	2x41	4x46	histamine_on	0	100	No	No	No	No	8	9
275	2x43	3x46	histamine_on	0	100	No	Yes	No	Yes	9	9
276	2x43	7x54	histamine_on	0	100	No	Yes	No	No	9	9
277	2x44	2x48	histamine_on	0	100	No	No	No	No	8	6
278	2x46	2x50	histamine_on	0	100	No	No	No	Yes	9	9
279	2x49	4x50	histamine_on	0	100	No	No	No	Yes	9	9
280	2x50	7x49	histamine_on	0	100	No	Yes	No	Yes	9	9
281	2x59	E1x50	histamine_on	0	100	No	No	Yes	Yes	8	9
282	2x60	3x28	histamine_on	0	100	No	Yes	No	Yes	8	9
283	2x60	7x38	histamine_on	0	100	No	Yes	Yes	Yes	8	8
284	2x60	7x42	histamine_on	0	100	No	Yes	Yes	Yes	8	9
285	2x63	E2x50	histamine_on	0	100	No	No	No	Yes	7	9
286	3x28	E1x50	histamine_on	0	100	No	Yes	Yes	Yes	9	9
287	3x24	E1x52	histamine_on	0	100	No	No	No	Yes	7	9
288	3x28	3x29	histamine_on	0	100	No	Yes	No	No	9	9
289	3x29	E2x52	histamine_on	0	100	No	No	No	No	9	9
290	3x32	3x36	histamine_on	0	100	No	Yes	No	No	9	9
291	3x33	E2	histamine_on	0	100	Yes	Yes	Yes	Yes	9	5
292	3x36	6x48	histamine_on	0	100	No	No	Yes	Yes	9	9
293	3x40	6x48	histamine_on	0	100	No	No	Yes	Yes	9	9
294	3x41	5x461	histamine_on	0	100	No	No	No	No	8	9
295	3x43	7x49	histamine_on	0	100	No	No	No	Yes	9	9
296	3x43	7x53	histamine_on	0	100	No	No	No	No	9	9
297	3x44	5x50	histamine_on	0	100	No	No	No	No	8	9
298	3x46	7x53	histamine_on	0	100	No	Yes	No	No	9	9
299	3x47	5x58	histamine_on	0	100	No	No	Yes	No	8	9
300	3x55	5x60	histamine_on	0	100	No	No	No	No	8	5
301	I2x54	I2x56	histamine_on	0	100	No	No	Yes	Yes	8	8
302	4x61	E2	histamine_on	0	100	No	No	Yes	Yes	9	5
303	7x31	E2	histamine_on	0	100	No	No	Yes	Yes	4	5
304	5x40	E2	histamine_on	0	100	No	No	Yes	Yes	9	5
305	5x36	5x39	histamine_on	0	100	No	No	Yes	Yes	8	9
306	5x51	6x44	histamine_on	0	100	No	No	Yes	Yes	9	9
307	5x54	6x44	histamine_on	0	100	Yes	No	Yes	Yes	9	9
308	5x62	6x34	histamine_on	0	100	No	No	No	No	8	9
309	5x65	6x33	histamine_on	0	100	No	No	No	No	9	9
310	5x66	5x68	histamine_on	0	100	No	No	No	No	7	8
311	5x67	6x29	histamine_on	0	100	No	No	No	Yes	5	8
312	5x68	6x30	histamine_on	0	100	No	No	No	No	8	8
313	6x29	6x30	histamine_on	0	100	No	Yes	No	No	8	8
314	6x48	7x45	histamine_on	0	100	Yes	Yes	Yes	No	9	9
315	6x52	6x55	histamine_on	0	100	Yes	Yes	No	No	9	8
316	6x54	6x58	histamine_on	0	100	No	No	No	No	7	6
317	6x58	7x30	histamine_on	0	100	No	No	No	No	6	6
318	7x30	7x31	histamine_on	0	100	No	No	No	No	6	4
319	7x55	8x54	histamine_on	0	100	No	No	Yes	Yes	8	9
320	8x47	8x48	histamine_on	0	100	No	No	No	No	9	5
321	1x29	1x32	histamine_on	0	100	No	No	No	No	0	0
322	1x60	2x50	histamine_on	0	100	No	No	No	Yes	8	9
323	2x38	3x49	histamine_on	0	100	No	Yes	No	No	9	9
324	2x43	8x47	histamine_on	0	100	No	Yes	No	No	9	9
325	2x43	8x50	histamine_on	0	100	No	Yes	No	No	9	9
326	2x55	3x31	histamine_on	0	100	No	No	No	No	7	8
327	2x60	2x64	histamine_on	0	100	No	Yes	No	No	8	8
328	2x63	E1x52	histamine_on	0	100	No	No	No	Yes	7	9
329	E1	E1x50	histamine_on	0	100	No	No	Yes	Yes	3	9
330	3x26	E2	histamine_on	0	100	No	No	Yes	Yes	8	5
331	3x49	I2x53	histamine_on	0	100	No	No	No	No	9	9
332	3x53	I2x53	histamine_on	0	100	No	No	No	No	9	9
333	4x56	4x57	histamine_on	0	100	No	No	Yes	Yes	0	8
334	6x55	E2	histamine_on	0	100	No	No	Yes	Yes	8	5
335	5x37	6x60	histamine_on	0	100	No	Yes	No	No	8	7
336	5x46	6x48	histamine_on	0	100	No	No	Yes	Yes	5	9
337	5x46	Lig	histamine_on	0	100	No	No	Yes	Yes	5	0
338	6x51	7x41	histamine_on	0	100	Yes	Yes	No	No	9	9
339	7x41	Lig	histamine_on	0	100	No	No	Yes	Yes	9	0
340	5x37	5x38	histamine_on	0	100	No	Yes	No	No	8	5
341	5x37	6x56	histamine_on	0	50	No	Yes	No	No	8	7
342	2x41	4x42	histamine_on	0	50	No	No	No	No	8	9
343	1x57	2x51	histamine_on	0	50	No	No	No	No	8	8
344	2x39	8x47	histamine_on	0	50	No	No	No	No	8	9
345	3x34	4x50	histamine_on	0	50	No	No	No	Yes	9	9
346	1x56	8x54	histamine_on	0	50	No	No	Yes	Yes	9	9
347	3x47	5x57	histamine_on	0	50	No	No	No	Yes	8	7
348	3x55	3x56	histamine_on	0	75	No	No	No	No	8	7
349	3x46	3x50	histamine_on	0	50	No	Yes	No	No	9	9
350	6x45	6x46	histamine_on	0	50	No	No	No	No	8	5
351	3x26	4x62	histamine_on	0	50	No	No	No	No	8	7
352	2x51	2x55	histamine_on	0	50	No	No	No	No	8	7
353	6x36	6x40	histamine_on	0	50	No	No	No	No	9	9
354	2x38	4x42	histamine_on	0	50	No	Yes	No	No	9	9
355	4x64	E2	histamine_on	0	50	No	No	Yes	Yes	0	5
356	6x38	6x41	histamine_on	0	50	No	No	No	No	8	9
357	8x53	8x54	histamine_on	0	50	No	No	Yes	Yes	8	9
358	2x64	2x65	histamine_on	0	50	No	No	No	Yes	8	6
359	7x48	7x52	histamine_on	0	50	No	No	No	Yes	8	9
360	1x54	2x44	histamine_on	0	50	No	No	No	No	8	8
361	1x52	8x58	histamine_on	0	50	No	Yes	No	No	9	8
362	6x40	7x52	histamine_on	0	25	No	No	No	Yes	9	9
363	6x33	6x37	histamine_on	0	50	No	No	No	No	9	9
364	5x48	6x53	histamine_on	0	50	No	Yes	No	No	8	7
365	3x45	4x49	histamine_on	0	50	No	No	No	No	8	7
366	4x40	4x43	histamine_on	0	50	No	No	No	No	6	6
367	4x54	4x59	histamine_on	0	50	No	No	No	No	5	8
368	2x37	8x49	histamine_on	0	50	No	No	No	No	9	9
369	6x45	6x49	histamine_on	0	50	No	No	No	No	8	8
370	1x59	1x60	histamine_on	0	50	No	No	No	No	7	8
371	1x32	2x65	histamine_on	0	50	No	No	No	Yes	0	6
372	2x57	2x58	histamine_on	0	25	Yes	Yes	No	No	9	9
373	6x27	6x28	histamine_on	0	50	No	No	No	No	3	7
374	4x51	4x55	histamine_on	0	0	No	No	No	No	5	5
375	1x35	2x65	histamine_on	0	50	No	No	No	Yes	9	6
376	1x48	1x52	histamine_on	0	50	No	No	No	Yes	6	9
377	6x25	6x28	histamine_on	0	50	No	No	No	No	5	7
378	5x65	6x29	histamine_on	0	50	No	No	No	Yes	9	8
379	6x43	7x52	histamine_on	0	25	No	No	No	Yes	8	9
380	5x63	5x66	histamine_on	0	50	No	No	No	No	6	7
381	1x37	1x41	histamine_on	0	50	No	No	No	No	4	5
382	1x44	1x48	histamine_on	0	50	No	No	No	No	7	6
383	6x25	6x29	histamine_on	0	50	No	No	No	Yes	5	8
384	5x42	5x46	histamine_on	0	0	No	No	No	No	7	5
385	1x42	7x43	histamine_on	0	25	No	No	No	No	7	6
386	4x51	4x54	histamine_on	0	50	No	No	No	No	5	5
387	1x38	1x42	histamine_on	0	50	No	No	No	No	4	7
388	1x47	1x51	histamine_on	0	50	No	No	No	No	6	8
389	1x29	1x31	histamine_on	0	25	No	No	No	No	0	0
390	1x52	CT	histamine_on	0	0	No	Yes	No	No	9	8
391	3x21	E1x50	histamine_on	0	0	No	No	Yes	Yes	8	9
392	6x26	6x27	histamine_on	0	0	No	No	No	No	5	3
393	1x31	1x34	histamine_on	0	0	No	No	No	No	0	3
394	5x48	5x52	histamine_on	0	0	No	Yes	No	No	8	5
395	5x37	5x41	histamine_on	0	0	No	Yes	No	No	8	8
396	4x38	4x41	histamine_on	0	0	No	No	No	No	9	9
397	3x30	4x54	histamine_on	0	0	No	No	No	No	9	5
398	4x38	I2x58	histamine_on	0	0	No	No	No	No	9	0
399	1x40	1x43	histamine_on	0	0	No	No	No	No	7	9
400	4x47	4x48	histamine_on	0	0	No	No	No	No	7	5
401	6x57	6x61	histamine_on	0	0	No	No	No	No	8	7
402	3x21	E1x51	histamine_on	0	0	No	No	No	No	8	5
403	I2x50	I2x51	histamine_on	0	0	No	No	No	No	9	8
404	7x51	7x55	histamine_on	0	0	No	No	No	No	7	8
405	7x55	8x51	histamine_on	0	0	No	No	No	No	8	8
406	1x33	E1	histamine_on	0	0	No	No	No	No	0	3
407	8x56	8x57	histamine_on	0	0	No	No	No	No	6	8
408	5x59	5x63	histamine_on	0	0	No	No	No	No	4	6
409	6x42	6x45	histamine_on	0	0	No	No	No	No	8	8
410	4x41	4x44	histamine_on	0	0	No	No	No	No	9	6
411	6x32	6x36	histamine_on	0	0	No	No	No	No	9	9
412	6x31	6x32	histamine_on	0	0	Yes	No	No	No	7	9

Orange: nodes, hubs and links specific of histamine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of histamine_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	histamine_off Avg Int. Strength	histamine_on Avg Int. Strength	histamine_off Num Of Links	histamine_on Num Of Links	ConSurf
1	NT	histamine_off	0	0	4	1	5
2	I1x50	histamine_off	0	0	4	1	9
3	2x56	histamine_off	25	0	4	2	9
4	3x37	histamine_off	75	50	4	3	9
5	I2x52	histamine_off	25	0	4	2	5
6	5x54	histamine_off	50	50	4	3	9
7	5x58	histamine_off	0	0	4	3	9
8	6x31	histamine_off	25	0	4	1	7
9	E3	histamine_off	25	0	4	2	4
10	7x34	histamine_off	0	0	4	2	7
11	7x39	histamine_off	100	50	6	3	9
12	7x45	histamine_off	75	0	4	3	9
13	2x42	Shared	50	50	7	4	8
14	2x57	Shared	75	50	6	6	9
15	E1x50	Shared	50	50	4	8	9
16	3x33	Shared	50	50	4	4	9
17	3x51	Shared	0	75	4	4	9
18	I2x56	Shared	25	50	4	4	8
19	4x57	Shared	75	50	5	4	8
20	E2	Shared	100	100	12	16	5
21	5x39	Shared	25	0	4	4	9
22	5x47	Shared	50	50	4	4	9
23	6x44	Shared	75	50	4	4	9
24	6x48	Shared	75	100	4	7	9
25	6x51	Shared	100	100	7	5	9
26	6x52	Shared	25	50	4	4	9
27	7x38	Shared	25	50	4	5	8
28	7x42	Shared	100	100	6	7	9
29	8x54	Shared	25	0	4	5	9
30	Lig	Shared	100	100	13	11	0
31	1x52	histamine_on	0	0	1	4	9
32	2x38	histamine_on	0	50	2	5	9
33	2x43	histamine_on	0	50	2	4	9
34	2x50	histamine_on	25	100	3	6	9
35	2x60	histamine_on	25	50	1	4	8
36	2x65	histamine_on	0	0	2	4	6
37	E1x52	histamine_on	0	0	2	4	9
38	3x28	histamine_on	50	50	2	4	9
39	3x32	histamine_on	25	50	3	4	9
40	3x46	histamine_on	0	0	1	4	9
41	4x50	histamine_on	0	75	2	4	9
42	E2x50	histamine_on	0	50	3	4	9
43	5x37	histamine_on	0	0	1	5	8
44	5x48	histamine_on	0	0	3	4	8
45	5x57	histamine_on	0	50	3	4	7
46	6x29	histamine_on	0	50	1	4	8
47	7x49	histamine_on	0	0	2	4	9
48	7x52	histamine_on	0	0	1	4	9

Orange: nodes, hubs and links specific of histamine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of histamine_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	histamine_off Recurrence	histamine_on Recurrence	histamine_off Hub1?	histamine_on Hub1?	histamine_off Hub2?	histamine_on Hub2?	ConSurf1	ConSurf2
1	7x39	7x42	histamine_off	17.4047	3.58368	Yes	No	Yes	Yes	9	9
2	2x56	7x42	histamine_off	31.3101	1.44023	Yes	No	Yes	Yes	9	9
3	2x53	2x56	histamine_off	50.6258	0	No	No	Yes	No	9	9
4	2x53	7x46	histamine_off	35.7348	5.04079	No	No	No	No	9	9
5	2x50	7x46	histamine_off	33.2281	6.70042	No	Yes	No	No	9	9
6	1x50	7x50	histamine_off	15.4831	1.68776	No	No	No	No	9	9
7	1x49	7x50	histamine_off	12.9197	0	No	No	No	No	9	9
8	3x40	Lig	histamine_off	71.1966	0	No	No	Yes	Yes	9	0
9	3x40	6x44	histamine_off	70.1613	0.35443	No	No	Yes	Yes	9	9
10	6x44	7x45	histamine_off	100	0	Yes	Yes	Yes	No	9	9
11	2x46	7x49	histamine_off	94.7669	1.54149	No	No	No	Yes	9	9
12	2x46	7x53	histamine_off	62.2336	0	No	No	No	No	9	9
13	2x43	7x53	histamine_off	59.5675	0	No	Yes	No	No	9	9
14	2x40	2x43	histamine_off	58.0642	0	No	No	No	Yes	9	9
15	2x40	I1x50	histamine_off	55.0222	0	No	No	Yes	No	9	9
16	8x50	I1x50	histamine_off	38.1244	1.24895	No	No	Yes	No	9	9
17	1x53	8x54	histamine_off	12.1858	0	No	No	Yes	Yes	9	9
18	1x53	2x47	histamine_off	10.4733	1.68776	No	No	No	No	9	9
19	1x60	I1x50	histamine_off	15.2774	0	No	No	Yes	No	8	9
20	1x60	8x53	histamine_off	11.8525	0	No	No	No	No	8	8
21	2x46	3x42	histamine_off	37.4863	0	No	No	No	No	9	8
22	2x45	3x42	histamine_off	35.8766	1.68776	No	No	No	No	9	8
23	2x45	4x46	histamine_off	31.0051	9.98594	No	No	No	No	9	9
24	2x42	4x46	histamine_off	22.7442	0	Yes	Yes	No	No	8	9
25	3x49	I2x57	histamine_off	11.1682	0	No	No	No	No	9	9
26	2x53	3x35	histamine_off	12.9197	3.3699	No	No	No	No	9	8
27	2x52	3x35	histamine_off	10.3492	1.68776	No	No	No	No	8	8
28	3x33	E2x52	histamine_off	30.062	5.1308	Yes	Yes	No	No	9	9
29	E2	E2x52	histamine_off	29.002	8.10127	Yes	Yes	No	No	5	9
30	2x63	E2	histamine_off	21.6522	0	No	No	Yes	Yes	7	5
31	5x43	Lig	histamine_off	35.9014	0	No	No	Yes	Yes	8	0
32	5x39	5x43	histamine_off	35.8376	1.04641	Yes	Yes	No	No	9	8
33	3x22	E2	histamine_off	10.2251	1.25457	No	No	Yes	Yes	5	5
34	3x37	3x41	histamine_off	10.7889	0	Yes	No	No	No	9	8
35	3x43	6x44	histamine_off	72.6999	0	No	No	Yes	Yes	9	9
36	3x43	5x54	histamine_off	71.2604	0	No	No	Yes	No	9	9
37	3x44	5x54	histamine_off	55.5965	6.52039	No	No	Yes	No	8	9
38	3x44	3x48	histamine_off	52.5403	0	No	No	No	No	8	6
39	5x54	6x41	histamine_off	14.9654	0	Yes	No	No	No	9	9
40	5x58	6x41	histamine_off	11.5299	4.84388	Yes	No	No	No	9	9
41	5x47	5x48	histamine_off	11.3136	8.29255	Yes	Yes	No	Yes	9	8
42	3x51	5x61	histamine_off	23.0527	4.89451	Yes	Yes	No	No	9	9
43	3x54	5x61	histamine_off	21.3792	3.26864	No	No	No	No	9	9
44	3x54	5x64	histamine_off	19.6986	1.63713	No	No	No	No	9	6
45	5x64	5x67	histamine_off	18.011	0	No	No	No	No	6	5
46	5x67	5x68	histamine_off	14.6144	0	No	No	No	No	5	8
47	8x47	8x50	histamine_off	12.1893	0	No	No	No	No	9	9
48	6x36	8x47	histamine_off	10.4662	0	No	No	No	No	9	9
49	E2	E3	histamine_off	12.4978	0	Yes	Yes	Yes	No	5	4
50	7x54	8x54	histamine_off	10.1294	0	No	No	Yes	Yes	9	9
51	5x68	6x31	histamine_off	12.902	0	No	No	Yes	No	8	7
52	2x63	E1x50	histamine_off	19.3866	2.09845	No	No	Yes	Yes	7	9
53	E1x50	E1x52	histamine_off	10.2358	7.94374	Yes	Yes	No	Yes	9	9
54	2x56	3x32	histamine_off	28.6049	2.00281	Yes	No	No	Yes	9	9
55	3x32	Lig	histamine_off	29.7642	2.40788	No	Yes	Yes	Yes	9	0
56	6x48	6x51	histamine_off	12.3276	0	Yes	Yes	Yes	Yes	9	9
57	1x50	2x50	Shared	25.6657	21.5021	No	No	No	Yes	9	9
58	7x42	Lig	Shared	56.2063	39.2799	Yes	Yes	Yes	Yes	9	0
59	7x45	7x49	Shared	96.0858	98.5823	Yes	No	No	Yes	9	9
60	8x50	8x54	Shared	25.0381	17.1533	No	No	Yes	Yes	9	9
61	6x48	Lig	Shared	69.8777	98.9648	Yes	Yes	Yes	Yes	9	0
62	6x44	6x48	Shared	81.5777	67.8143	Yes	Yes	Yes	Yes	9	9
63	2x42	3x49	Shared	12.5651	27.4318	Yes	Yes	No	No	8	9
64	3x33	Lig	Shared	37.3373	43.7018	Yes	Yes	Yes	Yes	9	0
65	5x39	E2	Shared	28.6049	14.4923	Yes	Yes	Yes	Yes	9	5
66	3x48	5x57	Shared	32.9445	17.4008	No	No	No	Yes	6	7
67	3x51	5x57	Shared	27.9667	14.346	Yes	Yes	No	Yes	9	7
68	3x48	3x52	Shared	19.6915	15.8594	No	No	No	No	6	8
69	3x52	I2x52	Shared	16.6424	14.706	No	No	Yes	No	8	5
70	6x52	Lig	Shared	26.1337	17.4233	Yes	Yes	Yes	Yes	9	0
71	5x47	6x52	Shared	31.3987	17.0689	Yes	Yes	Yes	Yes	9	9
72	5x47	6x49	Shared	13.175	14.6835	Yes	Yes	No	No	9	8
73	2x57	7x42	Shared	11.8986	12.3994	Yes	Yes	Yes	Yes	9	9
74	6x48	7x45	histamine_on	0	100	Yes	Yes	Yes	No	9	9
75	2x50	7x49	histamine_on	0	38.6217	No	Yes	No	Yes	9	9
76	1x50	2x51	histamine_on	7.77167	18.3966	No	No	No	No	9	8
77	3x43	7x49	histamine_on	0	75.1111	No	No	No	Yes	9	9
78	3x43	7x53	histamine_on	0	74.0535	No	No	No	No	9	9
79	3x46	7x53	histamine_on	0	59.9156	No	Yes	No	No	9	9
80	2x43	3x46	histamine_on	0	29.609	No	Yes	No	Yes	9	9
81	2x43	8x50	histamine_on	0	19.4374	No	Yes	No	No	9	9
82	2x42	3x46	histamine_on	1.74437	32.9226	Yes	Yes	No	Yes	8	9
83	2x38	3x49	histamine_on	0	23.6681	No	Yes	No	No	9	9
84	2x38	4x42	histamine_on	0	14.391	No	Yes	No	No	9	9
85	2x41	4x42	histamine_on	0	13.2152	No	No	No	No	8	9
86	2x41	4x46	histamine_on	0	11.6062	No	No	No	No	8	9
87	2x60	7x42	histamine_on	0	25.5696	No	Yes	Yes	Yes	8	9
88	2x60	3x28	histamine_on	0	29.519	No	Yes	No	Yes	8	9
89	3x28	E1x50	histamine_on	0	26.1716	No	Yes	Yes	Yes	9	9
90	5x54	6x44	histamine_on	0	64.827	Yes	No	Yes	Yes	9	9
91	3x47	5x54	histamine_on	1.7621	59.2293	No	No	Yes	No	8	9
92	3x47	5x58	histamine_on	0	28.2925	No	No	Yes	No	8	9
93	3x47	5x57	histamine_on	0	34.8129	No	No	No	Yes	8	7
94	I2x52	I2x56	histamine_on	8.40986	13.5921	Yes	No	Yes	Yes	5	8
95	3x33	E2	histamine_on	0	36.0619	Yes	Yes	Yes	Yes	9	5
96	4x60	5x39	histamine_on	2.65556	13.5696	No	No	Yes	Yes	9	9
97	4x59	4x60	histamine_on	1.44301	12.4669	No	No	No	No	8	9
98	5x36	E2	histamine_on	2.86474	14.7904	No	No	Yes	Yes	8	5
99	5x36	5x38	histamine_on	1.49973	14.0534	No	No	No	No	8	5
100	5x37	5x38	histamine_on	0	12.4838	No	Yes	No	No	8	5
101	5x51	6x44	histamine_on	0	11.8987	No	No	Yes	Yes	9	9
102	5x47	5x51	histamine_on	5.68693	11.3699	Yes	Yes	No	No	9	9
103	5x58	6x37	histamine_on	4.59138	22.4866	Yes	No	No	No	9	9
104	6x33	6x37	histamine_on	0	21.007	No	No	No	No	9	9
105	5x65	6x33	histamine_on	0	19.4824	No	No	No	No	9	9
106	5x65	6x29	histamine_on	0	18.3629	No	No	No	Yes	9	8
107	6x29	6x30	histamine_on	0	11.218	No	Yes	No	No	8	8
108	6x40	7x53	histamine_on	1.74437	18.7511	No	No	No	No	9	9
109	6x40	7x52	histamine_on	0	11.5837	No	No	No	Yes	9	9
110	2x60	2x64	histamine_on	0	23.2968	No	Yes	No	No	8	8
111	3x21	E1x50	histamine_on	0	10.0141	No	No	Yes	Yes	8	9
112	2x64	2x65	histamine_on	0	18.121	No	No	No	Yes	8	6
113	4x54	4x59	histamine_on	0	10.8917	No	No	No	No	5	8
114	1x32	2x65	histamine_on	0	10.9592	No	No	No	Yes	0	6
115	7x38	Lig	histamine_on	2.69456	25.5921	Yes	Yes	Yes	Yes	8	0
116	2x60	7x38	histamine_on	0	24.1013	No	Yes	Yes	Yes	8	8
117	3x29	E2x52	histamine_on	0	12.27	No	No	No	No	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	7.665	9.8875	1	1	2	1
2x56	7x42	Shared	7.8875	5.6125	1	1	2	1
2x57	7x39	Shared	5.235	3.7925	1	1	2	2
2x57	7x42	Shared	5.0875	5.025	1	1	2	1
2x60	7x39	histamine_off	8.475	0	0	1	2	2
3x32	7x42	Shared	6.0375	10.525	1	1	1	1
3x32	Lig	Shared	11.63	9.5275	1	1	1	0
3x33	4x57	Shared	8.2	14.1125	1	1	1	1
3x33	E2x52	Shared	4.0575	4.03	1	1	1	2
3x33	Lig	Shared	20.925	22.2625	1	1	1	0
3x36	Lig	Shared	9.5325	7.3	0	1	1	0
3x37	3x41	histamine_off	4.865	0	1	0	2	2
3x37	4x57	Shared	6.975	5.58	1	0	2	1
3x37	5x461	Shared	6.58	5.12	1	0	2	1
3x40	5x50	histamine_off	6.3475	0	0	1	1	2
3x40	6x44	Shared	6.5925	4.505	0	1	1	2
3x40	Lig	histamine_off	4.4425	0	0	1	1	0
4x57	5x43	Shared	7.885	5.8325	1	0	1	1
4x57	5x461	histamine_off	6.78	0	1	0	1	1
4x57	Lig	histamine_off	4.0175	0	1	0	1	0
E2	E2	Shared	46.855	65.3225	1	1	2	2
E2	E2x52	Shared	15.9675	13.055	1	1	2	2
5x39	E2	Shared	18.8225	5.1525	1	1	2	2
5x39	5x43	Shared	3.5675	4.27	1	1	2	1
5x40	6x55	Shared	8.3775	11.265	0	1	2	1
5x43	Lig	histamine_off	3.8225	0	1	0	1	0
5x461	Lig	Shared	9.2975	3.73	1	0	1	0
5x47	6x52	Shared	30.545	12.45	0	0	2	1
6x44	6x48	Shared	6.265	5.51	0	1	2	1
6x44	7x45	histamine_off	7.8525	0	0	1	2	2
6x48	6x51	histamine_off	5.7875	0	1	1	1	1
6x48	7x41	Shared	9.8525	12.98	1	1	1	1
6x48	Lig	Shared	12.45	3.5725	1	1	1	0
6x51	6x52	histamine_off	3.35	0	1	1	1	1
6x51	6x55	histamine_off	9.0275	0	1	1	1	1
6x51	7x37	Shared	6.8675	4.1625	1	1	1	2
6x51	7x38	Shared	5.14	6.03	1	1	1	1
6x51	Lig	Shared	12.45	13.425	1	1	1	0
6x52	Lig	Shared	15.515	4.415	1	0	1	0
6x55	Lig	histamine_off	6.795	0	1	1	1	0
7x38	7x42	Shared	4.8375	8.3425	1	1	1	1
7x38	Lig	Shared	4.085	7.2025	1	1	1	0
7x39	7x42	Shared	8.4425	5.21	1	1	2	1
7x42	Lig	Shared	3.6425	4.4075	1	1	1	0
3x33	4x61	histamine_off	4.23	0	1	1	1	2
6x51	7x34	Shared	6.26	6.055	1	1	1	2
7x34	7x38	Shared	4.97	3.315	1	1	2	1
5x44	6x52	Shared	2.425	3.14	0	0	2	1
5x46	5x49	histamine_off	2.14	0	0	1	1	2
5x49	5x50	Shared	2.05	3.335	0	0	2	2
2x60	7x38	histamine_on	0	4.3125	0	1	2	1
2x60	7x42	histamine_on	0	11.12	0	1	2	1
3x32	3x36	histamine_on	0	3.3775	1	1	1	1
3x33	E2	histamine_on	0	4.3825	1	1	1	2
3x36	6x48	histamine_on	0	3.775	0	1	1	1
3x40	6x48	histamine_on	0	11.62	0	1	1	1
3x41	5x461	histamine_on	0	3.625	0	0	2	1
4x61	E2	histamine_on	0	4.655	0	0	2	2
5x40	E2	histamine_on	0	9.145	0	1	2	2
6x48	7x45	histamine_on	0	7.91	1	1	1	2
6x52	6x55	histamine_on	0	4.285	1	0	1	1
4x56	4x57	histamine_on	0	4.435	0	0	2	1
6x55	E2	histamine_on	0	3.5675	1	1	1	2
5x46	6x48	histamine_on	0	3.27	0	1	1	1
5x46	Lig	histamine_on	0	4.67	0	1	1	0
6x51	7x41	histamine_on	0	3.945	1	1	1	1
7x41	Lig	histamine_on	0	8.0925	0	1	1	0
5x42	5x46	histamine_on	0	1.8175	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	histamine_off	h1_off
	histamine_on	h1_on h4_on

Network Difference
Value	histamine_off	histamine_on
I_min	3.3275	3.2475
Number of Linked Nodes	249	256
Number of Specific Nodes	6 (2.41%)	13 (5.08%)
Number of Shared Nodes	243 (97.59%)	243 (94.92%)
Number of Links	268	285
Number of Specific Links	127 (47.39%)	144 (50.53%)
Number of Shared Links	141 (52.61%)	141 (49.47%)
Number of Hubs	30	36
Number of Specific Hubs	12 (40.00%)	18 (50.00%)
Number of Shared Hubs	18 (60.00%)	18 (50.00%)
Average % Shared Neighbours (Jaccard)	34.54
Average % Shared Neighbours (Otsuka)	44.58
Average % Shared Neighbours (Overlap Coefficient)	55.83
Average % Shared Cliques (k3-6)	80.65
Graphlets Similarity	0.593016

Paths Difference
Value	histamine_off	histamine_on
Number Of Nodes in MetaPath	72	61
Specific Nodes in MetaPath	40 (55.56%)	29 (47.54%)
Shared Nodes in MetaPath	243 (97.59%)	243 (97.59%)
Number Of Links MetaPath	73	61
Specific Links in MetaPath	56 (76.71%)	44 (72.13%)
Shared Links in MetaPath	141 (52.61%)	141 (52.61%)
Number of Shortest Paths	63536	38323
Length Of Smallest Path	3	3
Average Path Length	14.1315	12.1254
Length of Longest Path	30	28
Minimum Path Strength	0.58125	0.29875
Average Path Strength	6.34219	5.9466
Maximum Path Strength	23.03	18.1875
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.911906	0.900239
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.7037	4.54545
Average % Of Corr. Nodes	44.7311	44.7381
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	40.1685	46.1784
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download histamine_off_on.zip<

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