psnGPCR

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Orange: nodes, hubs and links specific of histamine_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of histamine_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	histamine_on Int. Strength	histamine_off Int. Strength	histamine_on Hub1?	histamine_off Hub1?	histamine_on Hub2?	histamine_off Hub2?	ConSurf1	ConSurf2
1	1x39	2x61	histamine_on	100	0	No	No	Yes	No	8	8
2	1x46	2x54	histamine_on	100	0	Yes	No	No	No	9	9
3	1x53	7x54	histamine_on	100	0	No	No	No	No	9	9
4	2x40	8x47	histamine_on	100	0	Yes	No	No	No	9	9
5	2x40	8x50	histamine_on	100	0	Yes	No	Yes	No	9	9
6	2x43	3x46	histamine_on	100	0	No	No	Yes	No	9	9
7	2x46	2x50	histamine_on	100	0	No	No	Yes	Yes	9	9
8	2x49	4x50	histamine_on	100	0	No	No	Yes	No	9	9
9	2x53	7x42	histamine_on	100	0	No	No	Yes	Yes	9	9
10	2x57	2x58	histamine_on	100	0	Yes	Yes	No	No	9	9
11	2x59	E1x50	histamine_on	100	0	No	No	Yes	Yes	8	9
12	2x60	3x28	histamine_on	100	0	Yes	No	Yes	No	8	9
13	2x60	7x38	histamine_on	100	0	Yes	No	Yes	Yes	8	8
14	3x24	E1x50	histamine_on	100	0	No	No	Yes	Yes	7	9
15	3x24	E1x52	histamine_on	100	0	No	No	No	No	7	9
16	3x28	3x29	histamine_on	100	0	Yes	No	No	No	9	9
17	3x33	E2	histamine_on	100	0	Yes	No	Yes	Yes	9	5
18	3x40	6x48	histamine_on	100	0	No	No	Yes	Yes	9	9
19	3x43	7x53	histamine_on	100	0	No	No	Yes	No	9	9
20	3x44	5x50	histamine_on	100	0	No	No	No	No	8	9
21	3x46	3x50	histamine_on	100	0	Yes	No	No	No	9	9
22	3x46	7x53	histamine_on	100	0	Yes	No	Yes	No	9	9
23	3x47	5x57	histamine_on	100	0	No	No	Yes	No	8	7
24	3x47	5x58	histamine_on	100	0	No	No	Yes	Yes	8	9
25	3x50	7x53	histamine_on	100	0	No	No	Yes	No	9	9
26	3x55	5x60	histamine_on	100	0	No	No	No	No	8	5
27	I2x54	I2x56	histamine_on	100	0	No	No	Yes	No	8	8
28	4x38	4x41	histamine_on	100	0	No	No	No	No	9	9
29	7x31	E2	histamine_on	100	0	No	No	Yes	Yes	4	5
30	5x40	E2	histamine_on	100	0	No	No	Yes	Yes	9	5
31	E2	E3	histamine_on	100	0	Yes	Yes	Yes	No	5	4
32	5x47	6x44	histamine_on	100	0	Yes	Yes	Yes	Yes	9	9
33	5x47	6x48	histamine_on	100	0	Yes	Yes	Yes	Yes	9	9
34	5x51	6x44	histamine_on	100	0	Yes	No	Yes	Yes	9	9
35	5x54	5x58	histamine_on	100	0	No	Yes	Yes	Yes	9	9
36	5x54	6x44	histamine_on	100	0	No	Yes	Yes	Yes	9	9
37	5x62	6x34	histamine_on	100	0	Yes	No	No	No	8	9
38	5x67	6x29	histamine_on	100	0	No	No	Yes	No	5	8
39	6x25	6x29	histamine_on	100	0	No	No	Yes	No	5	8
40	6x29	6x30	histamine_on	100	0	Yes	No	Yes	No	8	8
41	6x43	7x52	histamine_on	100	0	No	No	No	No	8	9
42	7x42	Lig	histamine_on	100	0	Yes	Yes	Yes	Yes	9	0
43	I1x48	I1x49	histamine_on	100	0	No	No	No	No	8	7
44	I1x48	I1x50	histamine_on	100	0	No	No	No	No	8	9
45	2x63	E2	histamine_on	100	0	No	No	Yes	Yes	7	5
46	3x42	4x49	histamine_on	100	0	No	No	No	No	8	7
47	3x53	I2x53	histamine_on	100	0	No	No	No	Yes	9	9
48	5x37	5x38	histamine_on	100	0	No	No	No	No	8	5
49	5x73	6x28	histamine_on	100	0	No	No	No	No	0	7
50	6x30	6x31	histamine_on	100	0	Yes	No	No	Yes	8	7
51	6x58	7x34	histamine_on	100	0	No	No	No	Yes	6	7
52	7x34	E3	histamine_on	100	0	No	Yes	Yes	No	7	4
53	8x47	8x49	histamine_on	100	0	No	No	No	No	9	9
54	1x57	I1x51	histamine_on	100	0	No	No	No	No	8	8
55	1x57	2x41	histamine_on	100	0	No	No	No	No	8	8
56	2x43	8x50	histamine_on	100	0	No	No	Yes	No	9	9
57	2x60	2x64	histamine_on	100	0	Yes	No	No	No	8	8
58	3x26	E2	histamine_on	100	0	No	No	Yes	Yes	8	5
59	3x48	3x52	histamine_on	100	0	No	No	No	No	6	8
60	4x40	4x41	histamine_on	100	0	No	No	No	No	6	9
61	5x69	6x26	histamine_on	100	0	No	No	No	No	5	5
62	I3	I3	histamine_on	100	0	Yes	No	Yes	No	0	0
63	6x51	7x41	histamine_on	100	0	Yes	Yes	No	No	9	9
64	6x58	E3	histamine_on	100	0	No	No	Yes	No	6	4
65	7x30	7x33	histamine_on	100	0	No	No	No	No	6	4
66	7x41	Lig	histamine_on	100	0	No	No	Yes	Yes	9	0
67	4x65	4x68	histamine_on	100	0	No	No	No	No	0	0
68	5x46	Lig	histamine_on	100	0	No	No	Yes	Yes	5	0
69	2x51	2x55	histamine_on	50	0	No	No	No	No	8	7
70	7x30	7x31	histamine_on	25	0	No	No	No	No	6	4
71	6x40	7x52	histamine_on	50	0	No	No	No	No	9	9
72	3x43	7x49	histamine_on	25	0	No	No	Yes	No	9	9
73	3x33	4x62	histamine_on	50	0	Yes	No	No	No	9	7
74	3x34	4x50	histamine_on	50	0	No	No	Yes	No	9	9
75	1x54	1x58	histamine_on	25	0	No	No	No	No	8	6
76	4x56	4x57	histamine_on	50	0	No	No	Yes	Yes	0	8
77	2x43	7x54	histamine_on	50	0	No	No	No	No	9	9
78	5x66	6x30	histamine_on	50	0	No	No	Yes	No	7	8
79	1x44	1x48	histamine_on	50	0	No	No	No	No	7	6
80	1x59	8x57	histamine_on	50	0	No	No	No	No	7	8
81	2x39	3x49	histamine_on	30	0	No	No	No	No	8	9
82	E1x49	E1x51	histamine_on	35	0	No	No	No	No	2	5
83	2x38	4x39	histamine_on	25	0	Yes	No	No	No	9	8
84	5x44	6x56	histamine_on	60	0	No	No	No	No	9	7
85	5x53	5x57	histamine_on	35	0	No	No	Yes	No	6	7
86	4x40	4x44	histamine_on	25	0	No	No	No	No	6	6
87	3x21	E1x50	histamine_on	30	0	No	No	Yes	Yes	8	9
88	8x47	8x48	histamine_on	25	0	No	No	No	No	9	5
89	2x41	4x46	histamine_on	35	0	No	No	No	No	8	9
90	1x42	1x46	histamine_on	15	0	No	No	Yes	No	7	9
91	5x37	6x60	histamine_on	50	0	No	No	No	No	8	7
92	2x61	2x62	histamine_on	50	0	Yes	No	No	No	8	6
93	5x65	6x33	histamine_on	25	0	No	No	No	No	9	9
94	2x38	4x42	histamine_on	0	0	Yes	No	No	No	9	9
95	5x37	5x41	histamine_on	25	0	No	No	No	No	8	8
96	6x22	6x23	histamine_on	25	0	No	No	No	No	0	0
97	6x24	I3	histamine_on	25	0	No	No	Yes	No	0	0
98	6x36	6x40	histamine_on	25	0	No	No	No	No	9	9
99	1x47	1x48	histamine_on	25	0	No	No	No	No	6	6
100	4x54	4x60	histamine_on	25	0	No	No	No	No	5	9
101	4x48	4x52	histamine_on	25	0	No	No	No	No	5	7
102	5x62	6x37	histamine_on	0	0	Yes	No	No	No	8	9
103	7x51	7x55	histamine_on	25	0	No	No	No	No	7	8
104	6x33	6x37	histamine_on	25	0	No	No	No	No	9	9
105	3x53	3x54	histamine_on	10	0	No	No	No	No	9	9
106	3x31	3x35	histamine_on	10	0	No	No	No	No	8	8
107	5x72	6x26	histamine_on	25	0	No	No	No	No	0	5
108	2x65	E1	histamine_on	25	0	Yes	No	No	No	6	3
109	5x73	6x26	histamine_on	25	0	No	No	No	No	0	5
110	5x40	6x59	histamine_on	25	0	No	No	No	No	9	8
111	7x55	8x54	histamine_on	25	0	No	No	Yes	Yes	8	9
112	1x37	1x41	histamine_on	25	0	No	No	No	No	4	5
113	1x45	7x47	histamine_on	10	0	No	No	No	No	4	9
114	1x59	1x60	histamine_on	30	0	No	No	Yes	No	7	8
115	3x26	4x63	histamine_on	25	0	No	No	No	No	8	7
116	6x45	6x46	histamine_on	25	0	No	No	No	No	8	5
117	4x51	4x55	histamine_on	5	0	No	No	No	No	5	5
118	1x60	8x56	histamine_on	25	0	Yes	No	No	No	8	6
119	5x38	5x42	histamine_on	25	0	No	No	No	No	5	7
120	4x65	E2	histamine_on	25	0	No	No	Yes	Yes	0	5
121	5x73	I3	histamine_on	25	0	No	No	Yes	No	0	0
122	6x38	6x41	histamine_on	25	0	No	No	Yes	No	8	9
123	2x61	2x65	histamine_on	0	0	Yes	No	Yes	No	8	6
124	5x67	5x71	histamine_on	25	0	No	No	No	No	5	0
125	6x43	7x48	histamine_on	0	0	No	No	No	No	8	8
126	2x38	I2x58	histamine_on	25	0	Yes	No	No	No	9	0
127	6x27	6x31	histamine_on	25	0	No	No	No	Yes	3	7
128	5x62	5x63	histamine_on	5	0	Yes	No	No	No	8	6
129	6x35	6x39	histamine_on	25	0	No	No	No	No	7	7
130	5x59	5x63	histamine_on	5	0	No	No	No	No	4	6
131	4x54	4x55	histamine_on	0	0	No	No	No	No	5	5
132	1x32	2x65	histamine_on	25	0	No	No	Yes	No	0	6
133	1x28	1x31	histamine_on	25	0	No	No	No	No	0	0
134	1x35	NT	histamine_on	0	0	No	No	No	Yes	9	5
135	4x66	4x69	histamine_on	25	0	No	No	No	No	0	0
136	4x69	E2	histamine_on	25	0	No	No	Yes	Yes	0	5
137	4x40	4x43	histamine_on	25	0	No	No	No	No	6	6
138	4x47	4x51	histamine_on	0	0	No	No	No	No	7	5
139	1x38	1x42	histamine_on	25	0	No	No	No	No	4	7
140	1x29	1x33	histamine_on	25	0	No	No	No	No	0	0
141	1x52	CT	histamine_on	0	0	No	No	No	No	9	8
142	5x70	I3	histamine_on	25	0	No	No	Yes	No	0	0
143	I2x51	I2x54	histamine_on	0	0	No	No	No	No	8	8
144	6x23	I3	histamine_on	0	0	No	No	Yes	No	0	0
145	1x38	1x41	histamine_on	0	0	No	No	No	No	4	5
146	1x52	8x58	histamine_on	5	0	No	No	No	No	9	8
147	1x28	1x30	histamine_on	0	0	No	No	No	No	0	0
148	5x74	5x75	histamine_on	0	0	No	No	No	No	0	0
149	1x33	1x37	histamine_on	0	0	No	No	No	No	0	4
150	I2x55	I2x56	histamine_on	0	0	No	No	Yes	No	5	8
151	4x63	4x64	histamine_on	0	0	No	No	No	No	7	0
152	6x41	6x42	histamine_on	0	0	Yes	No	No	No	9	8
153	4x67	4x68	histamine_on	5	0	No	No	No	No	0	0
154	1x29	1x31	histamine_on	5	0	No	No	No	No	0	0
155	8x52	8x55	histamine_on	0	0	No	No	No	No	7	8
156	1x39	7x39	Shared	100	100	No	No	Yes	Yes	8	9
157	1x43	2x57	Shared	100	100	No	No	Yes	Yes	9	9
158	1x46	2x57	Shared	100	100	Yes	No	Yes	Yes	9	9
159	1x46	7x47	Shared	100	100	Yes	No	No	No	9	9
160	1x50	2x50	Shared	100	100	No	No	Yes	Yes	9	9
161	1x50	7x50	Shared	100	100	No	No	No	No	9	9
162	1x53	2x47	Shared	100	100	No	No	No	No	9	9
163	1x55	8x57	Shared	100	0	No	No	No	No	5	8
164	2x40	I1x50	Shared	100	100	Yes	No	No	No	9	9
165	8x50	I1x50	Shared	100	100	Yes	No	No	No	9	9
166	2x37	2x40	Shared	100	100	No	No	Yes	No	9	9
167	2x41	4x42	Shared	100	0	No	No	No	No	8	9
168	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	8
169	2x42	3x46	Shared	100	100	Yes	Yes	Yes	No	8	9
170	2x42	3x49	Shared	100	100	Yes	Yes	No	No	8	9
171	2x42	4x45	Shared	100	100	Yes	Yes	No	No	8	8
172	2x45	3x42	Shared	100	100	No	No	No	No	9	8
173	2x45	4x46	Shared	100	100	No	No	No	No	9	9
174	2x45	4x50	Shared	100	100	No	No	Yes	No	9	9
175	2x46	3x42	Shared	100	100	No	No	No	No	9	8
176	2x46	7x49	Shared	100	100	No	No	Yes	No	9	9
177	2x50	3x39	Shared	100	100	Yes	Yes	No	No	9	9
178	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
179	2x50	7x49	Shared	100	100	Yes	Yes	Yes	No	9	9
180	2x52	3x35	Shared	100	33.3333	No	No	No	No	8	8
181	2x53	3x35	Shared	100	33.3333	No	No	No	No	9	8
182	2x53	7x46	Shared	100	100	No	No	No	No	9	9
183	2x54	2x57	Shared	100	100	No	No	Yes	Yes	9	9
184	2x551	3x31	Shared	100	100	No	No	No	No	6	8
185	2x56	3x32	Shared	100	100	No	Yes	No	No	9	9
186	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	9	9
187	2x59	3x28	Shared	100	100	No	No	Yes	No	8	9
188	2x60	7x39	Shared	100	100	Yes	No	Yes	Yes	8	9
189	2x60	7x42	Shared	100	100	Yes	No	Yes	Yes	8	9
190	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	7	9
191	E1x49	E2	Shared	100	100	No	No	Yes	Yes	2	5
192	E1x50	E1x52	Shared	100	100	Yes	Yes	No	No	9	9
193	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	9
194	3x28	E1x50	Shared	100	33.3333	Yes	No	Yes	Yes	9	9
195	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	9	9
196	3x22	E2	Shared	100	100	No	No	Yes	Yes	5	5
197	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
198	3x27	3x31	Shared	100	100	No	No	No	No	8	8
199	3x32	7x42	Shared	100	100	No	No	Yes	Yes	9	9
200	3x32	Lig	Shared	100	100	No	No	Yes	Yes	9	0
201	3x33	4x57	Shared	100	100	Yes	No	Yes	Yes	9	8
202	3x33	E2x52	Shared	100	100	Yes	No	No	No	9	9
203	3x33	Lig	Shared	100	100	Yes	No	Yes	Yes	9	0
204	3x36	6x48	Shared	100	100	No	No	Yes	Yes	9	9
205	3x36	Lig	Shared	100	100	No	No	Yes	Yes	9	0
206	3x37	3x41	Shared	100	100	Yes	Yes	No	No	9	8
207	3x37	4x53	Shared	100	100	Yes	Yes	No	No	9	9
208	3x37	4x57	Shared	100	100	Yes	Yes	Yes	Yes	9	8
209	3x37	5x461	Shared	100	100	Yes	Yes	No	No	9	9
210	3x38	4x50	Shared	100	100	No	No	Yes	No	9	9
211	3x40	6x44	Shared	100	100	No	No	Yes	Yes	9	9
212	3x41	4x49	Shared	100	33.3333	No	No	No	No	8	7
213	3x44	5x53	Shared	100	100	No	No	No	No	8	6
214	3x47	5x54	Shared	100	100	No	No	No	Yes	8	9
215	3x48	5x57	Shared	100	100	No	No	Yes	No	6	7
216	3x51	3x55	Shared	100	66.6667	No	Yes	No	No	9	8
217	3x51	5x57	Shared	100	100	No	Yes	Yes	No	9	7
218	3x51	5x60	Shared	100	100	No	Yes	No	No	9	5
219	3x52	I2x52	Shared	100	100	No	No	No	Yes	8	5
220	I2x52	I2x56	Shared	100	100	No	Yes	Yes	No	5	8
221	4x41	I2x56	Shared	100	100	No	No	Yes	No	9	8
222	4x57	5x43	Shared	100	100	Yes	Yes	No	No	8	8
223	4x61	E2	Shared	100	33.3333	No	No	Yes	Yes	9	5
224	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	5	5
225	5x36	E2	Shared	100	100	No	No	Yes	Yes	8	5
226	5x39	E2	Shared	100	100	No	Yes	Yes	Yes	9	5
227	E2	E2x51	Shared	100	100	Yes	Yes	No	No	5	7
228	E2	E2x52	Shared	100	100	Yes	Yes	No	No	5	9
229	5x39	5x43	Shared	100	100	No	Yes	No	No	9	8
230	5x40	6x55	Shared	100	100	No	No	No	No	9	8
231	5x47	5x48	Shared	100	100	Yes	Yes	No	No	9	8
232	5x47	5x51	Shared	100	100	Yes	Yes	Yes	No	9	9
233	5x47	6x49	Shared	100	33.3333	Yes	Yes	No	No	9	8
234	5x47	6x52	Shared	100	100	Yes	Yes	No	No	9	9
235	5x49	5x50	Shared	100	0	No	No	No	No	7	9
236	5x56	5x57	Shared	100	100	No	No	Yes	No	4	7
237	5x56	5x60	Shared	100	100	No	No	No	No	4	5
238	5x58	6x37	Shared	100	66.6667	Yes	Yes	No	No	9	9
239	5x58	6x41	Shared	100	100	Yes	Yes	Yes	No	9	9
240	5x62	5x66	Shared	100	100	Yes	No	No	No	8	7
241	5x68	6x30	Shared	100	33.3333	No	No	Yes	No	8	8
242	6x40	7x53	Shared	100	33.3333	No	No	Yes	No	9	9
243	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	9
244	6x47	7x45	Shared	100	100	No	No	No	Yes	9	9
245	6x48	7x41	Shared	100	100	Yes	Yes	No	No	9	9
246	6x48	7x45	Shared	100	100	Yes	Yes	No	Yes	9	9
247	6x51	6x55	Shared	100	100	Yes	Yes	No	No	9	8
248	6x51	7x34	Shared	100	100	Yes	Yes	No	Yes	9	7
249	6x51	7x37	Shared	100	100	Yes	Yes	No	No	9	9
250	6x51	7x38	Shared	100	100	Yes	Yes	Yes	Yes	9	8
251	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	9	0
252	6x52	Lig	Shared	100	100	No	No	Yes	Yes	9	0
253	6x54	6x58	Shared	100	0	No	No	No	No	7	6
254	6x57	E3	Shared	100	33.3333	No	No	Yes	No	8	4
255	6x61	E3	Shared	100	100	No	No	Yes	No	7	4
256	7x38	7x42	Shared	100	100	Yes	Yes	Yes	Yes	8	9
257	7x38	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
258	7x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	9	9
259	7x45	7x49	Shared	100	100	No	Yes	Yes	No	9	9
260	1x47	2x55	Shared	100	0	No	No	No	No	6	7
261	1x57	2x44	Shared	100	100	No	No	No	No	8	8
262	3x49	I2x53	Shared	100	100	No	No	No	Yes	9	9
263	3x56	I2x52	Shared	100	100	No	No	No	Yes	7	5
264	5x45	5x48	Shared	100	66.6667	No	No	No	No	7	8
265	7x30	7x32	Shared	100	33.3333	No	No	No	No	6	2
266	1x60	I1x49	Shared	100	100	Yes	No	No	No	8	7
267	5x36	5x38	Shared	100	100	No	No	No	No	8	5
268	5x44	6x52	Shared	50	33.3333	No	No	No	No	9	9
269	6x39	7x52	Shared	25	100	No	No	No	No	7	9
270	6x50	7x40	Shared	60	66.6667	No	No	No	No	9	9
271	6x49	6x53	Shared	25	33.3333	No	No	No	No	8	7
272	2x44	2x48	Shared	50	0	No	No	No	No	8	6
273	4x59	4x60	Shared	75	33.3333	No	No	No	No	8	9
274	6x49	6x50	Shared	50	100	No	No	No	No	8	9
275	3x54	5x61	Shared	50	33.3333	No	No	No	No	9	9
276	5x55	6x41	Shared	30	33.3333	No	No	Yes	No	7	9
277	3x56	I2x50	Shared	50	0	No	No	No	No	7	9
278	1x52	8x54	Shared	60	100	No	No	Yes	Yes	9	9
279	8x50	8x54	Shared	35	100	Yes	No	Yes	Yes	9	9
280	6x36	7x56	Shared	25	100	No	No	No	No	9	9
281	6x29	6x32	Shared	25	0	Yes	No	No	No	8	9
282	7x36	7x40	Shared	25	100	No	No	No	No	5	9
283	1x50	2x51	Shared	50	33.3333	No	No	No	No	9	8
284	1x51	2x51	Shared	25	100	No	No	No	No	8	8
285	1x56	8x54	Shared	50	33.3333	No	No	Yes	Yes	9	9
286	7x35	7x39	Shared	25	33.3333	No	No	Yes	Yes	6	9
287	1x54	2x48	Shared	5	66.6667	No	No	No	No	8	6
288	8x48	8x51	Shared	50	33.3333	No	No	No	No	5	8
289	3x30	4x58	Shared	50	100	No	No	No	No	9	5
290	3x34	4x54	Shared	30	100	No	No	No	No	9	5
291	5x51	6x45	Shared	25	100	Yes	No	No	No	9	8
292	1x49	7x50	Shared	50	100	No	No	No	No	9	9
293	5x69	6x30	Shared	25	33.3333	No	No	Yes	No	5	8
294	5x64	5x67	Shared	30	33.3333	No	No	No	No	6	5
295	2x38	I2x57	Shared	25	100	Yes	No	No	Yes	9	9
296	3x30	4x61	Shared	25	33.3333	No	No	No	No	9	9
297	1x60	8x53	Shared	25	100	Yes	No	No	No	8	8
298	2x66	E1x51	Shared	25	0	No	No	No	No	5	5
299	1x36	2x65	Shared	0	33.3333	No	No	Yes	No	7	6
300	3x41	4x52	Shared	5	100	No	No	No	No	8	7
301	8x52	8x56	Shared	25	0	No	No	No	No	7	6
302	1x35	1x39	Shared	25	33.3333	No	No	No	No	9	8
303	4x43	4x47	Shared	0	33.3333	No	No	No	No	6	7
304	7x43	7x48	Shared	10	33.3333	No	No	No	No	6	8
305	3x22	3x23	Shared	5	33.3333	No	No	No	No	5	5
306	1x40	2x61	Shared	0	100	No	No	Yes	No	7	8
307	5x51	5x52	Shared	0	0	Yes	No	No	No	9	5
308	1x34	NT	Shared	0	0	No	No	No	Yes	3	5
309	NT	NT	histamine_off	0	100	No	Yes	No	Yes	5	5
310	1x43	2x58	histamine_off	0	100	No	No	No	No	9	9
311	1x53	8x54	histamine_off	0	100	No	No	Yes	Yes	9	9
312	1x54	2x47	histamine_off	0	100	No	No	No	No	8	9
313	2x40	2x43	histamine_off	0	100	Yes	No	No	No	9	9
314	2x42	4x42	histamine_off	0	100	Yes	Yes	No	No	8	9
315	2x42	4x46	histamine_off	0	100	Yes	Yes	No	No	8	9
316	2x43	7x53	histamine_off	0	100	No	No	Yes	No	9	9
317	2x46	7x53	histamine_off	0	100	No	No	Yes	No	9	9
318	2x53	2x56	histamine_off	0	100	No	No	No	Yes	9	9
319	2x56	3x28	histamine_off	0	100	No	Yes	Yes	No	9	9
320	2x56	7x42	histamine_off	0	100	No	Yes	Yes	Yes	9	9
321	2x57	7x39	histamine_off	0	100	Yes	Yes	Yes	Yes	9	9
322	2x59	3x24	histamine_off	0	100	No	No	No	No	8	7
323	2x64	7x35	histamine_off	0	100	No	No	No	No	8	6
324	3x22	3x26	histamine_off	0	100	No	No	No	No	5	8
325	3x40	5x50	histamine_off	0	100	No	No	No	No	9	9
326	3x40	Lig	histamine_off	0	100	No	No	Yes	Yes	9	0
327	3x43	6x44	histamine_off	0	100	No	No	Yes	Yes	9	9
328	3x44	3x48	histamine_off	0	100	No	No	No	No	8	6
329	3x44	5x54	histamine_off	0	100	No	No	No	Yes	8	9
330	3x45	4x45	histamine_off	0	100	No	No	No	No	8	8
331	3x50	6x33	histamine_off	0	100	No	No	No	No	9	9
332	3x51	5x61	histamine_off	0	100	No	Yes	No	No	9	9
333	3x52	I2x53	histamine_off	0	100	No	No	No	Yes	8	9
334	3x53	I2x57	histamine_off	0	100	No	No	No	Yes	9	9
335	4x57	5x461	histamine_off	0	100	Yes	Yes	No	No	8	9
336	4x57	Lig	histamine_off	0	100	Yes	Yes	Yes	Yes	8	0
337	5x38	5x39	histamine_off	0	100	No	No	No	Yes	5	9
338	5x461	Lig	histamine_off	0	100	No	No	Yes	Yes	9	0
339	5x54	6x41	histamine_off	0	100	No	Yes	Yes	No	9	9
340	5x58	6x38	histamine_off	0	100	Yes	Yes	No	No	9	8
341	6x36	8x47	histamine_off	0	100	No	No	No	No	9	9
342	6x39	7x56	histamine_off	0	100	No	No	No	No	7	9
343	6x44	7x45	histamine_off	0	100	Yes	Yes	No	Yes	9	9
344	6x48	6x51	histamine_off	0	100	Yes	Yes	Yes	Yes	9	9
345	6x48	Lig	histamine_off	0	100	Yes	Yes	Yes	Yes	9	0
346	6x54	7x33	histamine_off	0	100	No	No	No	No	7	4
347	6x54	7x34	histamine_off	0	100	No	No	No	Yes	7	7
348	6x55	Lig	histamine_off	0	100	No	No	Yes	Yes	8	0
349	7x34	7x38	histamine_off	0	100	No	Yes	Yes	Yes	7	8
350	7x54	8x54	histamine_off	0	100	No	No	Yes	Yes	9	9
351	8x47	8x50	histamine_off	0	100	No	No	Yes	No	9	9
352	3x49	I2x57	histamine_off	0	100	No	No	No	Yes	9	9
353	3x50	6x37	histamine_off	0	100	No	No	No	No	9	9
354	I2x53	I2x57	histamine_off	0	100	No	Yes	No	Yes	9	9
355	3x52	I2x57	histamine_off	0	100	No	No	No	Yes	8	9
356	5x68	6x31	histamine_off	0	100	No	No	No	Yes	8	7
357	7x31	7x34	histamine_off	0	100	No	No	No	Yes	4	7
358	6x25	6x31	histamine_off	0	33.3333	No	No	No	Yes	5	7
359	6x27	6x30	histamine_off	0	33.3333	No	No	Yes	No	3	8
360	2x61	7x39	histamine_off	0	66.6667	Yes	No	Yes	Yes	8	9
361	1x58	2x44	histamine_off	0	33.3333	No	No	No	No	6	8
362	I1x48	I1x51	histamine_off	0	66.6667	No	No	No	No	8	8
363	2x39	2x42	histamine_off	0	33.3333	No	No	Yes	Yes	8	8
364	4x38	I2x56	histamine_off	0	33.3333	No	No	Yes	No	9	8
365	6x35	7x56	histamine_off	0	66.6667	No	No	No	No	7	9
366	3x29	E2x50	histamine_off	0	33.3333	No	No	No	No	9	9
367	4x38	4x40	histamine_off	0	33.3333	No	No	No	No	9	6
368	6x43	7x45	histamine_off	0	66.6667	No	No	No	Yes	8	9
369	3x43	5x54	histamine_off	0	66.6667	No	No	No	Yes	9	9
370	1x45	1x49	histamine_off	0	33.3333	No	No	No	No	4	9
371	1x55	1x59	histamine_off	0	33.3333	No	No	No	No	5	7
372	5x46	5x49	histamine_off	0	66.6667	No	No	No	No	5	7
373	5x48	6x56	histamine_off	0	33.3333	No	No	No	No	8	7
374	3x26	4x62	histamine_off	0	66.6667	No	No	No	No	8	7
375	6x39	7x55	histamine_off	0	33.3333	No	No	No	No	7	8
376	6x28	6x31	histamine_off	0	33.3333	No	No	No	Yes	7	7
377	2x41	4x39	histamine_off	0	33.3333	No	No	No	No	8	8
378	8x49	I1x50	histamine_off	0	0	No	No	No	No	9	9
379	2x49	3x39	histamine_off	0	0	No	No	No	No	9	9
380	6x32	8x48	histamine_off	0	33.3333	No	No	No	No	9	5
381	1x56	8x53	histamine_off	0	0	No	No	No	No	9	8
382	5x65	6x31	histamine_off	0	33.3333	No	No	No	Yes	9	7
383	7x32	7x33	histamine_off	0	33.3333	No	No	No	No	2	4
384	4x63	E2	histamine_off	0	33.3333	No	No	Yes	Yes	7	5
385	4x43	4x46	histamine_off	0	33.3333	No	No	No	No	6	9
386	5x41	5x45	histamine_off	0	33.3333	No	No	No	No	8	7
387	3x21	3x23	histamine_off	0	0	No	No	No	No	8	5
388	I2x52	I2x54	histamine_off	0	33.3333	No	Yes	No	No	5	8
389	5x67	5x68	histamine_off	0	33.3333	No	No	No	No	5	8
390	2x65	NT	histamine_off	0	33.3333	Yes	No	No	Yes	6	5
391	2x62	2x66	histamine_off	0	33.3333	No	No	No	No	6	5
392	1x49	7x51	histamine_off	0	33.3333	No	No	No	No	9	7
393	2x62	E1x52	histamine_off	0	33.3333	No	No	No	No	6	9
394	1x47	2x54	histamine_off	0	0	No	No	No	No	6	9
395	3x54	5x64	histamine_off	0	0	No	No	No	No	9	6
396	5x41	6x59	histamine_off	0	0	No	No	No	No	8	8
397	5x65	6x34	histamine_off	0	0	No	No	No	No	9	9
398	4x50	4x54	histamine_off	0	0	Yes	No	No	No	9	5
399	1x36	1x37	histamine_off	0	0	No	No	No	No	7	4
400	7x33	E3	histamine_off	0	33.3333	No	No	Yes	No	4	4
401	2x52	2x551	histamine_off	0	0	No	No	No	No	8	6
402	4x48	4x51	histamine_off	0	0	No	No	No	No	5	5
403	1x35	1x38	histamine_off	0	33.3333	No	No	No	No	9	4
404	4x60	5x39	histamine_off	0	0	No	No	No	Yes	9	9
405	E1	E2	histamine_off	0	33.3333	No	No	Yes	Yes	3	5
406	2x65	2x66	histamine_off	0	0	Yes	No	No	No	6	5
407	6x59	6x60	histamine_off	0	0	No	No	No	No	8	7
408	4x52	4x55	histamine_off	0	0	No	No	No	No	7	5
409	7x48	7x51	histamine_off	0	33.3333	No	No	No	No	8	7
410	3x50	6x34	histamine_off	0	33.3333	No	No	No	No	9	9
411	4x41	I2x55	histamine_off	0	33.3333	No	No	No	No	9	5
412	1x42	7x39	histamine_off	0	0	No	No	Yes	Yes	7	9
413	I2x51	I2x53	histamine_off	0	0	No	No	No	Yes	8	9
414	1x48	1x51	histamine_off	0	0	No	No	No	No	6	8
415	5x37	6x59	histamine_off	0	33.3333	No	No	No	No	8	8
416	7x54	8x51	histamine_off	0	0	No	No	No	No	9	8
417	1x41	1x45	histamine_off	0	0	No	No	No	No	5	4
418	8x51	8x55	histamine_off	0	0	No	No	No	No	8	8
419	8x48	8x52	histamine_off	0	0	No	No	No	No	5	7
420	8x58	8x59	histamine_off	0	0	No	No	No	No	8	6
421	5x58	5x62	histamine_off	0	0	Yes	Yes	Yes	No	9	8
422	1x59	8x53	histamine_off	0	0	No	No	No	No	7	8
423	1x41	1x44	histamine_off	0	0	No	No	No	No	5	7
424	5x42	5x46	histamine_off	0	0	No	No	No	No	7	5
425	5x63	5x67	histamine_off	0	0	No	No	No	No	6	5
426	8x55	8x56	histamine_off	0	0	No	No	No	No	8	6

Orange: nodes, hubs and links specific of histamine_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of histamine_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	histamine_on Avg Int. Strength	histamine_off Avg Int. Strength	histamine_on Num Of Links	histamine_off Num Of Links	ConSurf
1	1x46	histamine_on	0	0	4	2	9
2	1x60	histamine_on	0	0	4	2	8
3	2x38	histamine_on	0	0	4	1	9
4	2x40	histamine_on	25	0	4	3	9
5	2x60	histamine_on	70	0	5	2	8
6	2x61	histamine_on	0	0	4	2	8
7	2x65	histamine_on	0	0	4	3	6
8	3x28	histamine_on	50	33.3333	4	3	9
9	3x33	histamine_on	70	33.3333	5	3	9
10	3x46	histamine_on	0	0	4	1	9
11	I2x56	histamine_on	25	33.3333	4	3	8
12	4x50	histamine_on	55	0	4	3	9
13	5x51	histamine_on	0	0	4	3	9
14	5x57	histamine_on	70	0	5	3	7
15	5x62	histamine_on	0	0	4	2	8
16	6x29	histamine_on	25	0	4	1	8
17	6x30	histamine_on	0	0	5	3	8
18	6x41	histamine_on	0	33.3333	4	3	9
19	E3	histamine_on	45	0	5	3	4
20	7x49	histamine_on	0	0	4	3	9
21	7x53	histamine_on	50	66.6667	4	3	9
22	8x50	histamine_on	25	33.3333	4	3	9
23	I3	histamine_on	0	0	6	0	0
24	2x42	Shared	50	33.3333	4	7	8
25	2x50	Shared	90	33.3333	5	4	9
26	2x57	Shared	25	66.6667	5	5	9
27	E1x50	Shared	75	66.6667	8	5	9
28	3x37	Shared	40	66.6667	4	4	9
29	4x57	Shared	60	66.6667	4	5	8
30	E2	Shared	100	100	17	11	5
31	5x47	Shared	75	33.3333	6	4	9
32	5x58	Shared	25	0	4	4	9
33	6x44	Shared	50	66.6667	5	4	9
34	6x48	Shared	100	100	6	6	9
35	6x51	Shared	95	100	6	6	9
36	7x38	Shared	75	33.3333	4	4	8
37	7x39	Shared	50	100	4	7	9
38	7x42	Shared	75	100	7	6	9
39	8x54	Shared	0	33.3333	4	5	9
40	Lig	Shared	100	100	9	11	0
41	NT	histamine_off	0	0	2	4	5
42	2x56	histamine_off	0	33.3333	1	4	9
43	3x51	histamine_off	25	0	3	4	9
44	I2x52	histamine_off	0	33.3333	3	4	5
45	I2x53	histamine_off	25	0	2	4	9
46	I2x57	histamine_off	0	33.3333	1	5	9
47	5x39	histamine_off	25	0	2	4	9
48	5x54	histamine_off	25	33.3333	3	4	9
49	6x31	histamine_off	0	33.3333	2	4	7
50	7x34	histamine_off	15	0	3	4	7
51	7x45	histamine_off	0	66.6667	3	5	9

Orange: nodes, hubs and links specific of histamine_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of histamine_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	histamine_on Recurrence	histamine_off Recurrence	histamine_on Hub1?	histamine_off Hub1?	histamine_on Hub2?	histamine_off Hub2?	ConSurf1	ConSurf2
1	1x46	2x57	histamine_on	17.7123	7.5708	Yes	No	Yes	Yes	9	9
2	2x53	7x42	histamine_on	26.3414	0	No	No	Yes	Yes	9	9
3	3x43	7x49	histamine_on	53.7599	0	No	No	Yes	No	9	9
4	3x43	7x53	histamine_on	52.8435	0	No	No	Yes	No	9	9
5	3x46	7x53	histamine_on	42.3737	0	Yes	No	Yes	No	9	9
6	2x43	3x46	histamine_on	32.7479	0	No	No	Yes	No	9	9
7	2x43	8x50	histamine_on	28.2987	0	No	No	Yes	No	9	9
8	I1x48	I1x50	histamine_on	12.1539	0	No	No	No	No	8	9
9	I1x48	I1x49	histamine_on	10.9079	0	No	No	No	No	8	7
10	2x41	4x46	histamine_on	12.9175	0	No	No	No	No	8	9
11	2x42	3x46	histamine_on	10.6628	1.65238	Yes	Yes	Yes	No	8	9
12	2x45	4x50	histamine_on	12.4312	6.56274	No	No	Yes	No	9	9
13	2x60	3x28	histamine_on	21.5425	0	Yes	No	Yes	No	8	9
14	2x60	7x38	histamine_on	12.3387	0	Yes	No	Yes	Yes	8	8
15	7x42	Lig	histamine_on	46.8229	0	Yes	Yes	Yes	Yes	9	0
16	3x33	4x57	histamine_on	16.394	0.649519	Yes	No	Yes	Yes	9	8
17	3x36	Lig	histamine_on	34.3555	0.763835	No	No	Yes	Yes	9	0
18	3x36	6x48	histamine_on	34.5083	0.789816	No	No	Yes	Yes	9	9
19	7x41	Lig	histamine_on	34.1907	0	No	No	Yes	Yes	9	0
20	6x48	7x41	histamine_on	44.2265	1.57963	Yes	Yes	No	No	9	9
21	5x47	6x44	histamine_on	26.8357	0	Yes	Yes	Yes	Yes	9	9
22	5x54	6x44	histamine_on	100	0	No	Yes	Yes	Yes	9	9
23	3x47	5x54	histamine_on	42.6751	2.20837	No	No	No	Yes	8	9
24	3x47	5x57	histamine_on	44.4235	0	No	No	Yes	No	8	7
25	5x54	5x58	histamine_on	55.673	0	No	Yes	Yes	Yes	9	9
26	3x48	3x52	histamine_on	23.1221	0	No	No	No	No	6	8
27	3x33	E2	histamine_on	51.7503	0	Yes	No	Yes	Yes	9	5
28	5x36	E2	histamine_on	10.9923	1.76669	No	No	Yes	Yes	8	5
29	5x62	6x37	histamine_on	45.0866	0	Yes	No	No	No	8	9
30	5x62	5x66	histamine_on	37.812	2.20837	Yes	No	No	No	8	7
31	5x66	6x30	histamine_on	35.7984	0	No	No	Yes	No	7	8
32	6x29	6x30	histamine_on	12.1096	0	Yes	No	Yes	No	8	8
33	6x40	7x53	histamine_on	11.559	1.616	No	No	Yes	No	9	9
34	5x69	6x30	histamine_on	16.6593	2.19797	No	No	Yes	No	5	8
35	5x69	6x26	histamine_on	15.1119	0	No	No	No	No	5	5
36	5x73	6x26	histamine_on	11.4626	0	No	No	No	No	0	5
37	1x42	1x46	histamine_on	12.9858	0	No	No	Yes	No	7	9
38	1x39	2x61	histamine_on	11.1169	0	No	No	Yes	No	8	8
39	1x38	1x42	histamine_on	11.3782	0	No	No	No	No	4	7
40	2x60	7x42	histamine_on	13.8861	3.31515	Yes	No	Yes	Yes	8	9
41	1x39	7x39	Shared	16.9969	10.7976	No	No	Yes	Yes	8	9
42	7x39	7x42	Shared	19.0507	31.125	Yes	Yes	Yes	Yes	9	9
43	2x57	7x42	Shared	23.737	29.6337	Yes	Yes	Yes	Yes	9	9
44	2x53	7x46	Shared	21.5506	23.6477	No	No	No	No	9	9
45	2x50	7x46	Shared	21.7194	23.788	Yes	Yes	No	No	9	9
46	1x50	2x50	Shared	11.137	15.708	No	No	Yes	Yes	9	9
47	2x50	7x49	Shared	16.8482	36.0249	Yes	Yes	Yes	No	9	9
48	8x50	I1x50	Shared	13.1345	46.9265	Yes	No	No	No	9	9
49	2x46	3x42	Shared	23.8214	60.9093	No	No	No	No	9	8
50	2x45	3x42	Shared	25.0874	59.6882	No	No	No	No	9	8
51	2x45	4x46	Shared	14.0027	53.4269	No	No	No	No	9	9
52	3x28	E1x50	Shared	14.9271	19.9013	Yes	No	Yes	Yes	9	9
53	3x33	Lig	Shared	59.4309	22.7851	Yes	No	Yes	Yes	9	0
54	3x37	4x57	Shared	13.0903	10.1897	Yes	Yes	Yes	Yes	9	8
55	3x37	3x41	Shared	10.9119	12.8813	Yes	Yes	No	No	9	8
56	6x44	6x48	Shared	75.3306	28.5061	Yes	Yes	Yes	Yes	9	9
57	6x52	Lig	Shared	31.9802	28.7088	No	No	Yes	Yes	9	0
58	5x47	6x52	Shared	32.2817	25.6846	Yes	Yes	No	No	9	9
59	3x48	5x57	Shared	25.0914	23.1904	No	No	Yes	No	6	7
60	3x52	I2x52	Shared	21.1688	27.8618	No	No	No	Yes	8	5
61	I2x52	I2x56	Shared	15.5982	15.5781	No	Yes	Yes	No	5	8
62	5x58	6x37	Shared	49.8694	23.4191	Yes	Yes	No	No	9	9
63	6x48	7x45	Shared	49.6363	64.7129	Yes	Yes	No	Yes	9	9
64	7x45	7x49	Shared	47.9884	86.2562	No	Yes	Yes	No	9	9
65	2x46	7x49	Shared	16.9768	100	No	No	Yes	No	9	9
66	7x38	Lig	Shared	10.2689	25.4456	Yes	Yes	Yes	Yes	8	0
67	2x56	7x42	histamine_off	0	13.6607	No	Yes	Yes	Yes	9	9
68	2x56	3x28	histamine_off	0	23.8815	No	Yes	Yes	No	9	9
69	E1x50	E1x52	histamine_off	3.5931	12.9488	Yes	Yes	No	No	9	9
70	2x62	E1x52	histamine_off	0	11.4731	No	No	No	No	6	9
71	2x62	2x66	histamine_off	0	10.2001	No	No	No	No	6	5
72	1x50	7x50	histamine_off	2.52803	10.6365	No	No	No	No	9	9
73	2x53	2x56	histamine_off	0	25.2065	No	No	No	Yes	9	9
74	8x50	8x54	histamine_off	7.71271	36.1548	Yes	No	Yes	Yes	9	9
75	2x40	I1x50	histamine_off	0.253205	49.3115	Yes	No	No	No	9	9
76	2x40	2x43	histamine_off	0	51.9096	Yes	No	No	No	9	9
77	2x43	7x53	histamine_off	0	53.1826	No	No	Yes	No	9	9
78	2x46	7x53	histamine_off	0	55.5001	No	No	Yes	No	9	9
79	1x53	8x54	histamine_off	0	11.3588	No	No	Yes	Yes	9	9
80	1x56	8x54	histamine_off	1.3022	11.1042	No	No	Yes	Yes	9	9
81	2x42	4x46	histamine_off	0	49.5453	Yes	Yes	No	No	8	9
82	2x54	2x57	histamine_off	1.61971	11.3432	No	No	Yes	Yes	9	9
83	2x56	3x32	histamine_off	2.04976	17.511	No	Yes	No	No	9	9
84	E2	E2x52	histamine_off	0.124593	20.6807	Yes	Yes	No	No	5	9
85	3x33	E2x52	histamine_off	1.29416	21.9174	Yes	No	No	No	9	9
86	3x32	Lig	histamine_off	2.80937	39.5999	No	No	Yes	Yes	9	0
87	6x48	Lig	histamine_off	0	69.9402	Yes	Yes	Yes	Yes	9	0
88	4x57	Lig	histamine_off	0	17.4331	Yes	Yes	Yes	Yes	8	0
89	5x461	Lig	histamine_off	0	10.6261	No	No	Yes	Yes	9	0
90	3x40	Lig	histamine_off	0	25.4819	No	No	Yes	Yes	9	0
91	3x40	6x44	histamine_off	0.301435	25.352	No	No	Yes	Yes	9	9
92	3x43	6x44	histamine_off	0	69.4414	No	No	Yes	Yes	9	9
93	3x44	5x54	histamine_off	0	29.3011	No	No	No	Yes	8	9
94	3x43	5x54	histamine_off	0	67.5812	No	No	No	Yes	9	9
95	3x44	3x48	histamine_off	0	25.2169	No	No	No	No	8	6
96	3x51	5x57	histamine_off	6.34219	16.9966	No	Yes	Yes	No	9	7
97	3x51	5x61	histamine_off	0	10.9119	No	Yes	No	No	9	9
98	3x52	I2x53	histamine_off	0	15.4222	No	No	No	Yes	8	9
99	3x49	I2x53	histamine_off	4.59789	18.119	No	No	No	Yes	9	9
100	2x42	3x49	histamine_off	7.16209	38.701	Yes	Yes	No	No	8	9
101	3x52	I2x57	histamine_off	0	15.4586	No	No	No	Yes	8	9
102	3x49	I2x57	histamine_off	0	19.4024	No	No	No	Yes	9	9
103	5x47	5x48	histamine_off	2.49588	11.5614	Yes	Yes	No	No	9	8
104	5x54	6x41	histamine_off	0	35.6664	No	Yes	Yes	No	9	9
105	5x58	6x41	histamine_off	8.48439	31.6082	Yes	Yes	Yes	No	9	9
106	8x47	8x50	histamine_off	0	11.1354	No	No	Yes	No	9	9
107	6x51	7x38	histamine_off	6.00056	13.3229	Yes	Yes	Yes	Yes	9	8
108	7x38	7x42	histamine_off	2.59234	36.3575	Yes	Yes	Yes	Yes	8	9
109	6x54	7x34	histamine_off	0	12.9696	No	No	No	Yes	7	7
110	7x54	8x54	histamine_off	0	12.7046	No	No	Yes	Yes	9	9
111	5x65	6x31	histamine_off	0	14.2738	No	No	No	Yes	9	7
112	5x65	6x34	histamine_off	0	15.9314	No	No	No	No	9	9
113	3x50	6x34	histamine_off	0	17.9683	No	No	No	No	9	9
114	3x50	6x37	histamine_off	0	21.3614	No	No	No	No	9	9
115	7x54	8x51	histamine_off	0	11.1198	No	No	No	No	9	8
116	3x32	7x42	histamine_off	1.1133	21.1691	No	No	Yes	Yes	9	9
117	6x48	6x51	histamine_off	0	22.7747	Yes	Yes	Yes	Yes	9	9
118	6x44	7x45	histamine_off	0	22.8787	Yes	Yes	No	Yes	9	9
119	6x51	7x34	histamine_off	6.88879	10.5586	Yes	Yes	No	Yes	9	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	2x56	histamine_off	3.74333	0	0	0	2	2
2x56	3x32	Shared	7.3	8.9005	1	0	2	1
2x56	7x42	histamine_off	6.73	0	1	0	2	1
2x57	7x39	histamine_off	5.04	0	1	1	2	2
2x57	7x42	Shared	6.78333	4.362	1	1	2	1
2x60	7x39	Shared	8.66333	4.2835	1	1	2	2
2x60	7x42	Shared	3.87667	5.704	1	1	2	1
3x32	7x42	Shared	5.36667	9.4	1	1	1	1
3x32	Lig	Shared	11.5733	9.5805	1	1	1	0
3x33	4x57	Shared	8.36	11.719	1	1	1	1
3x33	E2x52	Shared	4.57667	3.2195	1	1	1	2
3x33	Lig	Shared	15.9	12.061	1	1	1	0
3x36	6x48	Shared	4.12	3.8455	1	0	1	1
3x36	Lig	Shared	9.95	6.132	1	0	1	0
3x37	4x57	Shared	7.28	3.9275	1	0	2	1
3x37	5x461	Shared	7.31	4.6775	1	0	2	1
3x40	5x50	histamine_off	6.20667	0	0	1	1	2
3x40	6x44	Shared	7.95333	3.8075	0	1	1	2
3x40	Lig	histamine_off	4.59	0	0	1	1	0
4x57	5x43	Shared	7.68333	3.7395	1	0	1	2
4x57	5x461	histamine_off	9.04	0	1	0	1	1
4x57	Lig	histamine_off	4.65667	0	1	0	1	0
E2	E2	Shared	52.28	46.9535	1	1	2	2
E2	E2x52	Shared	17.4467	8.4275	1	1	2	2
5x461	Lig	histamine_off	8.90333	0	1	0	1	0
5x47	6x52	Shared	27.8667	9.881	0	1	2	1
6x44	6x48	Shared	6.01333	3.758	1	1	2	1
6x44	7x45	histamine_off	7.24667	0	1	1	2	2
6x48	6x51	histamine_off	7.39667	0	1	1	1	1
6x48	7x41	Shared	11.26	9.406	1	1	1	1
6x48	7x45	Shared	3.76667	8.136	1	1	1	2
6x48	Lig	histamine_off	12.0133	0	1	1	1	0
6x51	6x55	Shared	10.66	4.493	1	1	1	1
6x51	7x34	Shared	4.71667	3.0775	1	1	1	2
6x51	7x37	Shared	6.24333	4.6545	1	1	1	2
6x51	7x38	Shared	5.24	4.2195	1	1	1	1
6x51	Lig	Shared	11.23	15.6855	1	1	1	0
6x52	Lig	Shared	16.8467	3.1525	0	0	1	0
6x55	Lig	histamine_off	6.30667	0	1	0	1	0
7x34	7x38	histamine_off	4.86	0	1	1	2	1
7x38	7x42	Shared	5.24	8.2015	1	1	1	1
7x38	Lig	Shared	4.99667	10.1305	1	1	1	0
7x39	7x42	Shared	8.68333	7.896	1	1	2	1
5x40	6x55	Shared	7.03333	6.539	0	1	2	1
5x46	5x49	histamine_off	2.85333	0	0	0	1	2
5x44	6x52	Shared	2.77	2.9845	0	0	2	1
5x49	5x50	Shared	2.18667	3.3765	0	0	2	2
5x42	5x46	histamine_off	0.486667	0	0	0	2	1
2x53	7x42	histamine_on	0	3.0165	0	0	2	1
2x60	7x38	histamine_on	0	6.568	1	1	2	1
3x33	E2	histamine_on	0	4.228	1	1	1	2
3x40	6x48	histamine_on	0	7.278	0	1	1	1
5x40	E2	histamine_on	0	3.5115	0	1	2	2
5x47	6x44	histamine_on	0	3.8595	0	1	2	2
5x47	6x48	histamine_on	0	4.111	0	1	2	1
7x42	Lig	histamine_on	0	6.9215	1	1	1	0
6x51	7x41	histamine_on	0	4.0815	1	1	1	1
7x41	Lig	histamine_on	0	5.2075	0	1	1	0
5x46	Lig	histamine_on	0	3.292	0	0	1	0
3x33	4x62	histamine_on	0	2.7795	1	1	1	2
4x56	4x57	histamine_on	0	2.6445	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	histamine_off	h1_off
	histamine_on	h1_on h2_on h3_on h4_on

Network Difference
Value	histamine_on	histamine_off
I_min	2.9995	3.66667
Number of Linked Nodes	278	249
Number of Specific Nodes	30 (10.79%)	1 (0.40%)
Number of Shared Nodes	248 (89.21%)	248 (99.60%)
Number of Links	308	271
Number of Specific Links	155 (50.32%)	118 (43.54%)
Number of Shared Links	153 (49.68%)	153 (56.46%)
Number of Hubs	40	28
Number of Specific Hubs	23 (57.50%)	11 (39.29%)
Number of Shared Hubs	17 (42.50%)	17 (60.71%)
Average % Shared Neighbours (Jaccard)	36.83
Average % Shared Neighbours (Otsuka)	46.38
Average % Shared Neighbours (Overlap Coefficient)	56.61
Average % Shared Cliques (k3-6)	77.27
Graphlets Similarity	0.549178

Paths Difference
Value	histamine_on	histamine_off
Number Of Nodes in MetaPath	63	73
Specific Nodes in MetaPath	22 (34.92%)	32 (43.84%)
Shared Nodes in MetaPath	248 (89.21%)	248 (89.21%)
Number Of Links MetaPath	66	79
Specific Links in MetaPath	40 (60.61%)	53 (67.09%)
Shared Links in MetaPath	153 (49.68%)	153 (49.68%)
Number of Shortest Paths	55512	45209
Length Of Smallest Path	3	3
Average Path Length	12.4988	13.1962
Length of Longest Path	28	28
Minimum Path Strength	0.67825	0.413333
Average Path Strength	4.9642	6.20244
Maximum Path Strength	13.8733	22.3567
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.905698	0.911136
Maximum Path Correlation	0.9885	0.99
Minimum % Of Corr. Nodes	3.84615	4
Average % Of Corr. Nodes	43.8524	46.4475
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	46.831	36.4397
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download histamine_off_on.zip<

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