psnGPCR

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Orange: nodes, hubs and links specific of kop_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of kop_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	kop_off Int. Strength	kop_on Int. Strength	kop_off Hub1?	kop_on Hub1?	kop_off Hub2?	kop_on Hub2?	ConSurf1	ConSurf2
1	NT.P56	NT.S55	kop_off	5.34	0	No	No	No	No	2	1
2	1x39	2x57	kop_off	5.99	0	No	No	Yes	No	6	7
3	1x43	2x54	kop_off	3.89	0	Yes	Yes	No	No	7	6
4	1x50	2x47	kop_off	4.69	0	No	No	No	No	9	8
5	1x52	8x54	kop_off	6.09	0	No	No	No	No	6	6
6	1x52	8x57	kop_off	4.87	0	No	No	No	No	6	4
7	1x53	7x53	kop_off	3.79	0	No	No	Yes	Yes	9	9
8	1x54	2x48	kop_off	4.24	0	Yes	No	No	No	7	6
9	1x55	1x59	kop_off	4.28	0	No	No	No	No	4	5
10	1x55	8x57	kop_off	7.5	0	No	No	No	No	4	4
11	1x56	8x53	kop_off	5.12	0	No	No	No	No	8	6
12	1x57	8x50	kop_off	3.77	0	No	No	Yes	Yes	7	8
13	1x58	2x44	kop_off	7.54	0	No	No	No	No	3	5
14	1x60	8x53	kop_off	4.03	0	No	No	No	No	5	6
15	2x40	I1x50	kop_off	5.61	0	No	No	No	No	7	7
16	8x50	I1x50	kop_off	7.46	0	Yes	Yes	No	No	8	7
17	2x38	3x49	kop_off	4.63	0	No	No	No	No	6	8
18	2x39	3x50	kop_off	6.47	0	No	No	Yes	No	8	9
19	2x39	6x33	kop_off	4.56	0	No	No	No	No	8	7
20	2x40	8x50	kop_off	7.25	0	No	No	Yes	Yes	7	8
21	2x41	4x42	kop_off	4.87	0	Yes	No	No	No	5	7
22	2x43	7x53	kop_off	12.09	0	No	No	Yes	Yes	8	9
23	2x45	3x38	kop_off	4.39	0	Yes	No	Yes	No	9	7
24	2x45	3x42	kop_off	8.77	0	Yes	No	No	No	9	7
25	2x45	4x49	kop_off	4.25	0	Yes	No	No	No	9	7
26	2x48	4x50	kop_off	4.56	0	No	No	Yes	No	6	9
27	2x53	3x35	kop_off	16.26	0	No	No	No	No	7	8
28	2x54	2x57	kop_off	6.02	0	No	No	Yes	No	6	7
29	2x56	3x31	kop_off	4.56	0	Yes	No	No	No	7	5
30	2x56	Lig	kop_off	5.74	0	Yes	No	Yes	Yes	7	0
31	2x58	2x59	kop_off	5.78	0	No	No	No	Yes	8	5
32	3x28	E1x50	kop_off	7.36	0	No	No	Yes	Yes	6	8
33	3x22	E2.G198	kop_off	5.03	0	No	No	No	No	2	4
34	3x33	4x56	kop_off	5.05	0	No	No	Yes	No	5	5
35	3x34	4x57	kop_off	10.14	0	Yes	Yes	No	No	5	6
36	3x35	6x48	kop_off	4.52	0	No	No	Yes	Yes	8	8
37	3x36	6x52	kop_off	5.25	0	No	No	No	Yes	7	8
38	3x37	3x41	kop_off	4.29	0	No	Yes	Yes	No	6	6
39	3x39	6x44	kop_off	3.96	0	No	No	Yes	No	9	9
40	3x40	3x41	kop_off	3.77	0	No	No	Yes	No	7	6
41	3x42	4x49	kop_off	4.56	0	No	No	No	No	7	7
42	3x43	6x44	kop_off	6.09	0	No	No	Yes	No	8	9
43	3x44	5x54	kop_off	7.6	0	No	No	No	No	7	8
44	3x46	6x37	kop_off	6.09	0	No	No	No	No	8	8
45	3x50	3x53	kop_off	5.53	0	Yes	No	No	No	9	8
46	3x50	6x33	kop_off	8.77	0	Yes	No	No	No	9	7
47	3x50	6x34	kop_off	10.35	0	Yes	No	No	No	9	6
48	3x50	6x37	kop_off	6.54	0	Yes	No	No	No	9	8
49	3x51	5x64	kop_off	18.52	0	Yes	Yes	No	No	7	5
50	3x54	5x64	kop_off	6.54	0	No	No	No	No	8	5
51	I2x52	I2x55	kop_off	5.53	0	No	No	No	No	4	4
52	I2x52	I2x57	kop_off	11.14	0	No	No	No	No	4	6
53	I2x55	I2x57	kop_off	7.15	0	No	No	No	No	4	6
54	4x38	I2x55	kop_off	4.34	0	No	No	No	No	7	4
55	4x40	4x43	kop_off	4.23	0	No	No	No	No	4	4
56	E2.G198	E2.Q213	kop_off	6.58	0	No	No	No	No	4	4
57	E2.I208	E2.T199	kop_off	4.56	0	No	No	No	No	4	4
58	E2.R202	E2.V205	kop_off	3.92	0	No	Yes	No	No	2	1
59	E2.V205	E2.V207	kop_off	6.41	0	No	No	No	No	1	3
60	5x32	E2x51	kop_off	3.82	0	No	No	No	No	1	4
61	5x32	E2.F214	kop_off	12.38	0	No	No	Yes	Yes	1	6
62	5x39	E2.F214	kop_off	6.22	0	No	No	Yes	Yes	5	6
63	5x35	E2.P215	kop_off	5.4	0	Yes	No	No	No	7	5
64	E2.D216	E2.D217	kop_off	6.65	0	No	No	No	No	2	1
65	5x32	5x36	kop_off	12.64	0	No	No	No	No	1	4
66	5x35	5x38	kop_off	4.01	0	Yes	No	No	No	7	4
67	5x37	5x41	kop_off	4.28	0	No	No	No	No	3	5
68	5x40	6x58	kop_off	4.05	0	Yes	No	No	No	4	5
69	5x58	6x38	kop_off	17.58	0	Yes	Yes	No	No	8	4
70	5x66	I3.R257	kop_off	7.43	0	No	No	No	No	4	4
71	5x67	I3.R257	kop_off	7.91	0	No	No	No	No	4	4
72	I3.L258	I3.R257	kop_off	18.22	0	No	No	No	No	5	4
73	6x24	I3.S260	kop_off	3.95	0	No	No	No	No	3	4
74	6x26	6x27	kop_off	9.68	0	No	No	No	No	4	3
75	6x27	6x30	kop_off	5.43	0	No	No	No	No	3	6
76	6x29	8x48	kop_off	5.26	0	No	No	Yes	No	5	4
77	6x32	6x35	kop_off	18.13	0	No	No	No	No	7	6
78	6x36	8x47	kop_off	4.07	0	No	No	No	No	8	8
79	6x39	7x56	kop_off	4.47	0	No	No	No	No	5	7
80	6x44	7x45	kop_off	7.25	0	Yes	No	Yes	No	9	9
81	6x48	6x51	kop_off	4.7	0	Yes	Yes	No	No	8	6
82	6x48	7x41	kop_off	4.22	0	Yes	Yes	No	No	8	7
83	6x48	Lig	kop_off	5.91	0	Yes	Yes	Yes	Yes	8	0
84	6x50	7x37	kop_off	3.77	0	No	No	No	No	9	7
85	6x51	7x38	kop_off	4.42	0	No	No	Yes	Yes	6	5
86	6x54	7x37	kop_off	4.19	0	No	No	No	No	5	7
87	6x56	6x60	kop_off	4.15	0	No	No	No	No	5	4
88	7x34	7x35	kop_off	6.95	0	No	No	No	Yes	4	4
89	8x48	8x49	kop_off	6.57	0	Yes	No	No	No	4	6
90	8x50	8x54	kop_off	9.65	0	Yes	Yes	No	No	8	6
91	3x51	5x61	kop_off	3.59	0	Yes	Yes	No	No	7	8
92	7x32	7x33	kop_off	3.26	0	No	No	No	No	2	4
93	1x45	7x47	kop_off	3.23	0	No	No	No	No	5	7
94	1x44	1x48	kop_off	3.21	0	No	No	No	No	5	4
95	7x43	7x47	kop_off	3.2	0	No	No	No	No	5	7
96	1x45	7x51	kop_off	3.07	0	No	No	No	No	5	7
97	2x66	E1x49	kop_off	3.07	0	No	No	No	No	4	4
98	5x51	5x55	kop_off	3.07	0	No	No	No	No	6	5
99	3x23	3x24	kop_off	2.98	0	No	No	No	No	1	5
100	6x40	7x49	kop_off	2.96	0	No	No	Yes	Yes	8	9
101	3x55	3x56	kop_off	2.95	0	No	No	No	No	7	6
102	7x43	7x48	kop_off	2.95	0	No	No	No	No	5	6
103	1x31	1x35	kop_off	2.94	0	No	No	No	No	4	5
104	5x45	5x49	kop_off	2.94	0	No	No	No	No	5	5
105	4x41	I2x52	kop_off	2.87	0	No	No	No	No	5	4
106	3x21	E1x50	kop_off	2.81	0	No	No	Yes	Yes	7	8
107	8x57	8x58	kop_off	2.79	0	No	No	No	No	4	5
108	8x58	8x59	kop_off	2.79	0	No	No	No	No	5	4
109	7x54	8x54	kop_off	2.77	0	No	No	No	No	7	6
110	3x30	3x34	kop_off	2.54	0	No	No	Yes	Yes	5	5
111	3x50	6x30	kop_off	2.43	0	Yes	No	No	No	9	6
112	2x64	2x65	kop_off	2.34	0	No	Yes	No	No	4	4
113	E2.E203	E2.R202	kop_off	2.33	0	No	No	No	Yes	1	2
114	4x64	E2.G198	kop_off	2.11	0	No	No	No	No	4	4
115	4x57	4x60	kop_off	1.95	0	No	No	No	No	6	5
116	1x30	NT.S55	kop_off	1.71	0	No	No	No	No	4	1
117	7x40	7x41	kop_off	1.71	0	No	No	No	No	8	7
118	2x41	4x39	kop_off	1.69	0	Yes	No	No	No	5	2
119	1x30	1x34	kop_off	1.62	0	No	No	No	No	4	5
120	E1x49	E2.V207	kop_off	1.62	0	No	No	No	No	4	3
121	4x56	4x59	kop_off	1.62	0	Yes	No	No	No	5	7
122	1x54	2x51	kop_off	1.61	0	Yes	No	No	No	7	8
123	6x27	I2x50	kop_off	1.61	0	No	No	No	No	3	8
124	5x51	6x45	kop_off	1.6	0	No	No	No	No	6	6
125	5x37	6x59	kop_off	1.58	0	No	No	No	No	3	4
126	1x31	NT.S55	kop_off	1.55	0	No	No	No	No	4	1
127	1x34	1x38	kop_off	1.54	0	No	No	No	No	5	5
128	4x58	4x62	kop_off	1.54	0	No	No	No	No	4	4
129	1x51	1x54	kop_off	1.53	0	No	No	Yes	No	4	7
130	I1x48	I1x51	kop_off	1.5	0	No	No	No	No	6	7
131	5x67	I3.L259	kop_off	1.5	0	No	No	No	Yes	4	3
132	1x57	I1x51	kop_off	1.45	0	No	No	No	No	7	7
133	2x41	I1x51	kop_off	1.45	0	Yes	No	No	No	5	7
134	8x59	CT.P347	kop_off	1.44	0	No	No	No	No	4	4
135	2x52	3x31	kop_off	1.43	0	No	No	No	No	6	5
136	5x62	5x63	kop_off	1.43	0	No	No	No	No	5	4
137	5x60	5x63	kop_off	1.38	0	No	No	No	No	4	4
138	E2.D204	E2.E203	kop_off	1.3	0	No	No	No	No	2	1
139	1x39	1x40	kop_off	1.27	0	No	No	No	No	6	4
140	6x26	6x28	kop_off	1.24	0	No	No	No	No	4	4
141	7x55	8x51	kop_off	1.24	0	No	No	No	No	6	8
142	3x51	3x52	kop_off	1.21	0	Yes	Yes	No	No	7	5
143	8x52	8x56	kop_off	1.19	0	No	No	No	No	5	3
144	8x55	8x56	kop_off	1.19	0	No	No	No	No	5	3
145	5x31	5x34	kop_off	1.12	0	No	No	No	No	4	1
146	1x31	1x32	Shared	6.77	2.54	No	No	No	No	4	4
147	1x39	2x61	Shared	8.9	2.2275	No	No	No	No	6	6
148	1x42	2x57	Shared	4.56	3.0425	No	Yes	Yes	No	7	7
149	1x42	7x47	Shared	8.08	4.535	No	Yes	No	No	7	7
150	1x43	2x57	Shared	4.98	5.6	Yes	Yes	Yes	No	7	7
151	1x43	2x58	Shared	4.33	5.055	Yes	Yes	No	No	7	8
152	1x49	7x50	Shared	4.06	2.03	No	No	No	No	7	9
153	1x50	2x50	Shared	5.39	5.385	No	No	No	Yes	9	9
154	1x50	7x50	Shared	11.4	6.5175	No	No	No	No	9	9
155	1x54	2x44	Shared	4.98	5.6	Yes	No	No	No	7	5
156	1x59	1x60	Shared	4.12	2.83	No	No	No	No	5	5
157	2x37	2x40	Shared	5.85	7.31	No	No	No	No	7	7
158	2x41	4x46	Shared	4.25	3.5425	Yes	No	No	No	5	7
159	2x42	3x46	Shared	5.99	5.09	Yes	Yes	No	No	7	8
160	2x42	3x49	Shared	8.05	5.175	Yes	Yes	No	No	7	8
161	2x42	4x42	Shared	6.67	3.3325	Yes	Yes	No	No	7	7
162	2x42	4x45	Shared	7.25	3.025	Yes	Yes	No	No	7	6
163	2x42	4x46	Shared	4.65	7.85	Yes	Yes	No	No	7	7
164	2x43	8x50	Shared	3.77	2.8275	No	No	Yes	Yes	8	8
165	2x45	4x46	Shared	20.43	15.325	Yes	No	No	No	9	7
166	2x45	4x50	Shared	10.17	6.4975	Yes	No	Yes	No	9	9
167	2x46	3x43	Shared	6.92	3.8075	No	Yes	No	No	9	8
168	2x46	7x53	Shared	4.69	3.5175	No	Yes	Yes	Yes	9	9
169	2x50	7x46	Shared	8.83	6.625	No	Yes	No	No	9	8
170	2x50	7x49	Shared	6.73	7.74	No	Yes	Yes	Yes	9	9
171	2x56	7x42	Shared	4.99	3.1225	Yes	No	Yes	Yes	7	6
172	2x57	7x42	Shared	17.96	9.5775	Yes	No	Yes	Yes	7	6
173	2x59	E1x52	Shared	16.08	5.6275	No	Yes	Yes	Yes	5	7
174	2x60	7x38	Shared	5.49	3.085	No	Yes	Yes	Yes	7	5
175	2x60	7x42	Shared	5.64	9.5825	No	Yes	Yes	Yes	7	6
176	2x60	Lig	Shared	9.5	9.9525	No	Yes	Yes	Yes	7	0
177	2x62	E1x52	Shared	3.89	4.54	No	No	Yes	Yes	4	7
178	2x64	7x35	Shared	10.92	24.8225	No	Yes	No	Yes	4	4
179	2x66	E1x51	Shared	6.71	3.775	No	No	No	No	4	1
180	2x67	E2.V207	Shared	4.43	1.1075	No	No	No	No	5	3
181	E1x50	E1x52	Shared	15.03	14.2825	Yes	Yes	Yes	Yes	8	7
182	3x25	E1x50	Shared	5.22	6.8575	No	No	Yes	Yes	9	8
183	E1x50	E2x50	Shared	23.51	16.6475	Yes	Yes	No	No	8	9
184	E1x51	E1x52	Shared	13	6.5	No	No	Yes	Yes	1	7
185	3x24	E1x52	Shared	7.31	5.48	No	No	Yes	Yes	5	7
186	3x22	E2.T199	Shared	5.78	10.4775	No	No	No	No	2	4
187	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
188	3x28	Lig	Shared	3.87	3.6825	No	No	Yes	Yes	6	0
189	3x30	4x61	Shared	6.19	5.805	No	No	No	No	5	4
190	3x32	Lig	Shared	33.47	16.065	No	No	Yes	Yes	6	0
191	3x33	Lig	Shared	6.09	7.44	No	No	Yes	Yes	5	0
192	3x34	4x50	Shared	8.68	10.13	Yes	Yes	Yes	No	5	9
193	3x34	4x54	Shared	7.63	2.5425	Yes	Yes	No	No	5	4
194	3x36	6x48	Shared	6.98	4.0725	No	No	Yes	Yes	7	8
195	3x36	Lig	Shared	11.01	8.6425	No	No	Yes	Yes	7	0
196	3x37	4x56	Shared	9.18	8.85	No	Yes	Yes	No	6	5
197	3x37	5x461	Shared	8.32	3.465	No	Yes	No	No	6	6
198	3x38	4x50	Shared	15.77	11.5225	Yes	No	Yes	No	7	9
199	3x38	4x53	Shared	4.8	4.8	Yes	No	No	No	7	8
200	3x40	5x50	Shared	6.77	3.39	No	No	No	No	7	9
201	3x40	6x44	Shared	7.54	2.8275	No	No	Yes	No	7	9
202	3x41	4x49	Shared	7.54	5.6525	Yes	No	No	No	6	7
203	3x45	4x45	Shared	5.83	4.3725	No	Yes	No	No	6	6
204	3x47	5x54	Shared	7.74	5.03	No	No	No	No	9	8
205	3x47	5x58	Shared	10.17	8.905	No	No	Yes	Yes	9	8
206	3x51	5x57	Shared	4.03	7.0575	Yes	Yes	No	No	7	7
207	3x51	5x60	Shared	7.03	7.325	Yes	Yes	No	No	7	4
208	3x54	5x65	Shared	4.47	5.215	No	No	No	No	8	8
209	3x55	5x64	Shared	8.36	2.79	No	No	No	No	7	5
210	4x38	4x39	Shared	5.25	3.9375	No	No	No	No	7	2
211	4x47	4x51	Shared	4.28	1.4275	No	No	No	No	4	4
212	4x63	E2.F214	Shared	4.87	3.3475	No	No	Yes	Yes	4	6
213	E2.E209	E2.K200	Shared	12.15	3.7125	No	Yes	No	No	3	2
214	E2.E209	E2.R202	Shared	16.28	6.1075	No	Yes	No	Yes	3	2
215	E2x50	Lig	Shared	4.12	4.5175	No	No	Yes	Yes	9	0
216	5x35	E2.F214	Shared	7.02	1.5025	Yes	No	Yes	Yes	7	6
217	5x34	5x35	Shared	17.81	21.79	No	No	Yes	No	1	7
218	5x34	5x38	Shared	15.03	4.26	No	No	No	No	1	4
219	5x36	5x40	Shared	16.59	7.6025	No	No	Yes	No	4	4
220	5x38	5x42	Shared	4.19	3.4925	No	No	No	No	4	3
221	5x40	6x55	Shared	7.27	4.725	Yes	No	No	No	4	5
222	5x43	Lig	Shared	8.7	4.995	No	No	Yes	Yes	5	0
223	5x44	5x48	Shared	5.24	3.6025	No	Yes	No	No	5	4
224	5x44	6x56	Shared	15.83	6.0875	No	Yes	No	No	5	5
225	5x45	5x46	Shared	6.28	3.7675	No	No	No	No	5	4
226	5x47	5x51	Shared	5.24	2.9475	Yes	Yes	No	No	8	6
227	5x47	6x49	Shared	6.49	5.5125	Yes	Yes	No	Yes	8	5
228	5x47	6x52	Shared	15.84	5.0925	Yes	Yes	No	Yes	8	8
229	5x49	5x50	Shared	5.08	3.39	No	No	No	No	5	9
230	5x58	6x37	Shared	3.79	8.2	Yes	Yes	No	No	8	8
231	6x36	7x56	Shared	4.15	3.115	No	No	No	No	8	7
232	6x44	6x48	Shared	22.05	8.265	Yes	No	Yes	Yes	9	8
233	6x47	7x45	Shared	7.87	5.9025	No	No	Yes	No	8	9
234	6x48	6x52	Shared	4.23	4.76	Yes	Yes	No	Yes	8	8
235	6x48	7x45	Shared	6.78	12.1475	Yes	Yes	Yes	No	8	9
236	6x51	6x55	Shared	4.42	4.05	No	No	No	No	6	5
237	6x54	7x34	Shared	7.22	8.51	No	No	No	No	5	4
238	6x55	Lig	Shared	10.19	10.66	No	No	Yes	Yes	5	0
239	7x31	7x35	Shared	8.21	4.1025	No	No	No	Yes	4	4
240	7x34	7x38	Shared	13.3	7.855	No	No	Yes	Yes	4	5
241	7x36	7x40	Shared	6.09	6.7	No	No	No	No	5	8
242	7x38	Lig	Shared	4.63	6.075	Yes	Yes	Yes	Yes	5	0
243	7x42	Lig	Shared	13.7	6.26	Yes	Yes	Yes	Yes	6	0
244	7x45	7x49	Shared	9.54	7.4925	Yes	No	Yes	Yes	9	9
245	7x49	7x53	Shared	8.14	4.07	Yes	Yes	Yes	Yes	9	9
246	8x47	8x49	Shared	8.08	2.3575	No	No	No	No	8	6
247	8x47	8x50	Shared	11.94	4.4775	No	No	Yes	Yes	8	8
248	8x48	8x52	Shared	8.14	1.455	Yes	No	No	No	4	5
249	2x63	E1x50	Shared	3.68	2.45	No	No	Yes	Yes	5	8
250	1x43	1x47	Shared	3.65	5.4825	Yes	Yes	No	No	7	6
251	E2.F214	E2x52	Shared	3.65	3.0475	Yes	Yes	No	No	6	4
252	1x46	2x54	Shared	3.64	1.82	No	No	No	No	8	6
253	5x58	5x61	Shared	3.59	2.99	Yes	Yes	No	No	8	8
254	6x32	8x48	Shared	3.49	4.94	No	No	Yes	No	7	4
255	2x49	3x38	Shared	3.36	2.52	No	No	Yes	No	8	7
256	E1x49	E2.I208	Shared	3.1	3.87	No	No	No	No	4	4
257	4x54	4x58	Shared	3.1	1.1625	No	No	No	No	4	4
258	5x54	6x41	Shared	3.07	2.69	No	No	No	No	8	8
259	3x44	5x53	Shared	3.04	4.94	No	No	No	No	7	6
260	3x45	3x48	Shared	3.04	3.0425	No	Yes	No	No	6	6
261	6x40	7x52	Shared	2.98	3.3525	No	No	No	Yes	8	8
262	6x43	7x52	Shared	2.98	3.3525	No	No	No	Yes	7	8
263	3x27	3x31	Shared	2.94	1.8375	No	No	No	No	5	5
264	2x41	4x43	Shared	2.91	2.9075	Yes	No	No	No	5	4
265	3x22	3x26	Shared	2.77	4.495	No	No	No	Yes	2	6
266	3x29	Lig	Shared	2.7	8.5975	No	No	Yes	Yes	4	0
267	6x54	7x33	Shared	2.64	4.625	No	No	No	No	5	4
268	7x51	7x55	Shared	2.51	4.7125	No	No	No	No	7	6
269	5x44	5x47	Shared	2.14	8.3075	No	Yes	Yes	Yes	5	8
270	1x48	1x49	Shared	1.84	1.84	No	No	No	No	4	7
271	4x44	4x48	Shared	1.64	0.41	No	No	No	No	3	4
272	4x55	4x56	Shared	1.62	1.615	No	No	Yes	No	4	5
273	5x40	6x59	Shared	1.61	2.81	Yes	No	No	No	4	4
274	1x38	1x42	Shared	1.6	1.2	No	No	No	Yes	5	7
275	1x41	1x45	Shared	1.6	1.2	No	No	No	No	5	5
276	2x55	2x56	Shared	1.57	0.785	No	No	Yes	No	4	7
277	E2.I208	E2.V201	Shared	1.54	2.6875	No	No	No	No	4	2
278	5x55	5x59	Shared	1.52	1.14	No	No	No	No	5	4
279	6x49	6x53	Shared	1.52	1.9	No	Yes	No	No	5	5
280	5x48	5x52	Shared	1.49	1.1175	No	No	No	No	4	3
281	5x56	5x60	Shared	1.49	1.8625	No	No	No	No	4	4
282	3x41	4x52	Shared	1.22	0.915	Yes	No	No	No	6	4
283	6x25	6x28	Shared	1.16	4.3625	No	No	No	No	3	4
284	1x36	2x65	kop_on	0	4.055	No	No	No	No	5	4
285	1x39	7x35	kop_on	0	12.1625	No	No	No	Yes	6	4
286	1x39	7x39	kop_on	0	4.3375	No	No	No	No	6	5
287	1x42	7x43	kop_on	0	3.9675	No	Yes	No	No	7	5
288	1x50	2x51	kop_on	0	5.08	No	No	No	No	9	8
289	1x53	2x47	kop_on	0	3.3925	No	No	No	No	9	8
290	1x53	7x54	kop_on	0	2.9675	No	No	No	No	9	7
291	1x56	1x60	kop_on	0	4.415	No	No	No	No	8	5
292	1x56	8x50	kop_on	0	8.1925	No	No	Yes	Yes	8	8
293	2x40	I1x48	kop_on	0	3.655	No	No	No	No	7	6
294	I1x49	I1x51	kop_on	0	4.31	No	No	No	No	5	7
295	2x44	I1x50	kop_on	0	3.7325	No	No	No	No	5	7
296	2x37	2x39	kop_on	0	3.14	No	No	No	No	7	8
297	2x42	3x45	kop_on	0	6.885	Yes	Yes	No	Yes	7	6
298	2x46	2x50	kop_on	0	6.45	No	Yes	No	Yes	9	9
299	2x46	3x42	kop_on	0	4.42	No	Yes	No	No	9	7
300	2x50	3x39	kop_on	0	4.4175	No	Yes	No	No	9	9
301	2x52	3x35	kop_on	0	13.73	No	No	No	No	6	8
302	2x53	7x46	kop_on	0	5.6525	No	No	No	No	7	8
303	2x56	3x32	kop_on	0	5.4225	Yes	No	No	No	7	6
304	2x59	E1x50	kop_on	0	3.51	No	Yes	Yes	Yes	5	8
305	2x59	3x24	kop_on	0	5.1775	No	Yes	No	No	5	5
306	2x59	3x28	kop_on	0	7.535	No	Yes	No	No	5	6
307	3x30	4x60	kop_on	0	2.9925	No	No	No	No	5	5
308	3x31	3x35	kop_on	0	3.54	No	No	No	No	5	8
309	3x34	3x35	kop_on	0	4.9425	Yes	Yes	No	No	5	8
310	3x34	4x53	kop_on	0	4.4475	Yes	Yes	No	No	5	8
311	3x36	3x37	kop_on	0	3.7325	No	No	No	Yes	7	6
312	3x37	5x43	kop_on	0	3.93	No	Yes	No	No	6	5
313	3x43	7x53	kop_on	0	5.275	No	No	Yes	Yes	8	9
314	3x44	5x50	kop_on	0	3.5	No	No	No	No	7	9
315	3x45	4x49	kop_on	0	3.645	No	Yes	No	No	6	7
316	3x46	7x53	kop_on	0	4.79	No	No	Yes	Yes	8	9
317	3x47	5x57	kop_on	0	4.3	No	No	No	No	9	7
318	3x49	I2x57	kop_on	0	14.59	No	No	No	No	8	6
319	3x50	5x58	kop_on	0	9.775	Yes	No	Yes	Yes	9	8
320	3x50	7x53	kop_on	0	5.145	Yes	No	Yes	Yes	9	9
321	3x51	3x55	kop_on	0	8.4	Yes	Yes	No	No	7	7
322	3x51	3x56	kop_on	0	6.26	Yes	Yes	No	No	7	6
323	3x52	I2x56	kop_on	0	6.2775	No	No	No	No	5	4
324	3x53	I2x57	kop_on	0	5.53	No	No	No	No	8	6
325	3x54	5x61	kop_on	0	6.85	No	No	No	No	8	8
326	4x41	I2x56	kop_on	0	3.1	No	No	No	No	5	4
327	4x38	4x41	kop_on	0	5.2525	No	No	No	No	7	5
328	E2.K200	E2.Q213	kop_on	0	12.2075	No	No	No	No	2	4
329	E2.D204	E2.R202	kop_on	0	3.87	No	No	No	Yes	2	2
330	E2.E209	E2x51	kop_on	0	4.31	No	Yes	No	No	3	4
331	E2.E209	Lig	kop_on	0	3.495	No	Yes	Yes	Yes	3	0
332	5x36	E2.F214	kop_on	0	6.2675	No	No	Yes	Yes	4	6
333	5x32	Lig	kop_on	0	6.1725	No	No	Yes	Yes	1	0
334	5x44	6x52	kop_on	0	8.7675	No	Yes	No	Yes	5	8
335	5x45	5x48	kop_on	0	3.0725	No	No	No	No	5	4
336	5x54	5x58	kop_on	0	3.025	No	No	Yes	Yes	8	8
337	5x62	6x34	kop_on	0	6.08	No	No	No	No	5	6
338	5x66	6x30	kop_on	0	4.5825	No	No	No	No	4	6
339	6x30	I3.L259	kop_on	0	4.15	No	No	No	Yes	6	3
340	6x29	6x32	kop_on	0	3.6175	No	No	No	No	5	7
341	6x40	7x53	kop_on	0	5.365	No	No	Yes	Yes	8	9
342	6x45	6x49	kop_on	0	3.1725	No	No	No	Yes	6	5
343	6x49	6x50	kop_on	0	3.9375	No	Yes	No	No	5	9
344	6x51	7x37	kop_on	0	3.2725	No	No	No	No	6	7
345	6x54	6x58	kop_on	0	8.745	No	No	No	No	5	5
346	6x58	Lig	kop_on	0	6.3625	No	No	Yes	Yes	5	0
347	7x31	Lig	kop_on	0	7.3075	No	No	Yes	Yes	4	0
348	7x34	Lig	kop_on	0	13.0375	No	No	Yes	Yes	4	0
349	7x38	7x42	kop_on	0	3.3275	Yes	Yes	Yes	Yes	5	6
350	7x54	8x50	kop_on	0	4.16	No	No	Yes	Yes	7	8
351	8x48	8x51	kop_on	0	5.0625	Yes	No	No	No	4	8
352	Lig	Lig	kop_on	0	36.2775	Yes	Yes	Yes	Yes	0	0
353	1x35	7x35	kop_on	0	3.325	No	No	No	Yes	5	4
354	2x46	7x49	kop_on	0	4.12	No	Yes	Yes	Yes	9	9
355	3x26	4x64	kop_on	0	3.05	No	Yes	No	No	6	4
356	3x43	7x49	kop_on	0	4.4625	No	No	Yes	Yes	8	9
357	6x23	6x26	kop_on	0	3.06	No	No	No	No	0	4
358	6x27	6x31	kop_on	0	3.87	No	No	No	No	3	5
359	6x51	Lig	kop_on	0	3.6925	No	No	Yes	Yes	6	0
360	6x52	Lig	kop_on	0	3.8675	No	Yes	Yes	Yes	8	0
361	8x50	I1x48	kop_on	0	5.835	Yes	Yes	No	No	8	6
362	5x31	5x32	kop_on	0	5.46	No	No	No	No	4	1
363	2x60	2x64	kop_on	0	4.2275	No	Yes	No	Yes	7	4
364	7x27	Lig	kop_on	0	3.41	No	No	Yes	Yes	0	0
365	2x41	I1x50	kop_on	0	2.915	Yes	No	No	No	5	7
366	4x43	4x47	kop_on	0	2.9075	No	No	No	No	4	4
367	4x40	4x44	kop_on	0	2.8525	No	No	No	No	4	3
368	1x57	2x44	kop_on	0	2.8275	No	No	No	No	7	5
369	6x26	I3.L259	kop_on	0	2.82	No	No	No	Yes	4	3
370	5x37	6x60	kop_on	0	2.7675	No	No	No	No	3	4
371	5x55	6x41	kop_on	0	2.6875	No	No	No	No	5	8
372	7x30	Lig	kop_on	0	2.68	No	No	Yes	Yes	3	0
373	2x38	2x42	kop_on	0	2.6675	No	No	Yes	Yes	6	7
374	6x31	6x35	kop_on	0	2.6675	No	No	No	No	5	6
375	E1x50	E2.I208	kop_on	0	2.6425	Yes	Yes	No	No	8	4
376	E2.R202	E2.V207	kop_on	0	2.6175	No	Yes	No	No	2	3
377	3x26	E2.G198	kop_on	0	2.615	No	Yes	No	No	6	4
378	5x68	I3.L259	kop_on	0	2.6075	No	No	No	Yes	6	3
379	2x43	3x46	kop_on	0	2.5525	No	No	No	No	8	8
380	E2.R202	E3.H304	kop_on	0	2.54	No	Yes	No	No	2	0
381	3x25	E2.T199	kop_on	0	2.535	No	No	No	No	9	4
382	1x52	7x55	kop_on	0	2.4375	No	No	No	No	6	6
383	2x48	2x52	kop_on	0	2.4225	No	No	No	No	6	6
384	5x65	I3.L259	kop_on	0	2.4225	No	No	No	Yes	8	3
385	2x54	7x46	kop_on	0	2.4	No	No	No	No	6	8
386	5x31	E2.D217	kop_on	0	2.3275	No	No	No	No	4	1
387	1x55	1x60	kop_on	0	2.32	No	No	No	No	4	5
388	3x48	3x52	kop_on	0	2.305	No	No	No	No	6	5
389	6x25	6x29	kop_on	0	2.3	No	No	No	No	3	5
390	3x56	I2x52	kop_on	0	2.2925	No	No	No	No	6	4
391	7x47	7x48	kop_on	0	2.2525	No	No	No	No	7	6
392	5x39	E2x52	kop_on	0	2.12	No	No	No	No	5	4
393	E2.D216	E2.K200	kop_on	0	2.075	No	No	No	No	2	2
394	E3.T302	Lig	kop_on	0	2.065	No	No	Yes	Yes	0	0
395	6x29	I3.L259	kop_on	0	2.06	No	No	No	Yes	5	3
396	5x64	5x67	kop_on	0	1.9775	No	No	No	No	5	4
397	3x23	3x27	kop_on	0	1.9225	No	No	No	No	1	5
398	E3.S303	Lig	kop_on	0	1.89	No	No	Yes	Yes	0	0
399	2x37	I1x51	kop_on	0	1.8775	No	No	No	No	7	7
400	6x28	6x31	kop_on	0	1.865	No	No	No	No	4	5
401	4x62	4x63	kop_on	0	1.8625	No	No	No	No	4	4
402	6x34	6x38	kop_on	0	1.84	No	No	No	No	6	4
403	5x59	5x63	kop_on	0	1.84	No	No	No	No	4	4
404	6x35	6x38	kop_on	0	1.82	No	No	No	No	6	4
405	7x48	7x51	kop_on	0	1.785	No	No	No	No	6	7
406	I2x53	I2x57	kop_on	0	1.73	No	No	No	No	5	6
407	5x36	5x37	kop_on	0	1.6975	No	No	No	No	4	3
408	8x53	I1x48	kop_on	0	1.69	No	No	No	No	6	6
409	1x31	7x32	kop_on	0	1.5475	No	No	No	No	4	2
410	3x56	I2x50	kop_on	0	1.53	No	No	No	No	6	8
411	6x39	7x52	kop_on	0	1.49	No	No	No	Yes	5	8
412	7x40	7x43	kop_on	0	1.4725	No	No	No	No	8	5
413	5x41	5x45	kop_on	0	1.47	No	No	No	No	5	5
414	6x24	6x25	kop_on	0	1.455	No	No	No	No	3	3
415	5x65	6x33	kop_on	0	1.4275	No	No	No	No	8	7
416	7x52	7x56	kop_on	0	1.3825	No	Yes	No	No	8	7
417	1x45	1x46	kop_on	0	1.38	No	No	No	No	5	8
418	1x43	1x44	kop_on	0	1.31	Yes	Yes	No	No	7	5
419	6x60	6x61	kop_on	0	1.2825	No	No	No	No	4	2
420	1x29	1x31	kop_on	0	1.27	No	No	No	No	0	4
421	1x33	2x64	kop_on	0	1.2625	No	No	No	Yes	5	4
422	1x58	1x59	kop_on	0	1.2525	No	No	No	No	3	5
423	1x36	2x64	kop_on	0	1.2475	No	No	No	Yes	5	4
424	6x57	E3.S301	kop_on	0	1.2125	No	No	No	No	4	2
425	3x21	E1x52	kop_on	0	1.1325	No	No	Yes	Yes	7	7
426	6x30	I3.S260	kop_on	0	1.125	No	No	No	No	6	4
427	5x33	E2.D216	kop_on	0	1.105	No	No	No	No	2	2
428	4x38	4x40	kop_on	0	1.1025	No	No	No	No	7	4
429	E2.D204	E2.V205	kop_on	0	1.095	No	No	No	No	2	1
430	3x26	4x61	kop_on	0	1.09	No	Yes	No	No	6	4
431	E2.F214	E2.P215	kop_on	0	1.08	Yes	Yes	No	No	6	5
432	7x28	E3.H304	kop_on	0	1.0275	No	No	No	No	0	0
433	I2x54	I2x55	kop_on	0	1.02	No	No	No	No	5	4
434	3x30	4x57	kop_on	0	0.93	No	No	No	No	5	6
435	6x23	I3.G261	kop_on	0	0.9275	No	No	No	No	0	3
436	I3.G261	I3.S260	kop_on	0	0.9275	No	No	No	No	3	4
437	7x29	7x32	kop_on	0	0.855	No	No	No	No	4	2
438	1x32	1x34	kop_on	0	0.8475	No	No	No	No	4	5
439	7x28	7x29	kop_on	0	0.84	No	No	No	No	0	4
440	8x52	8x55	kop_on	0	0.8	No	No	No	No	5	5
441	6x53	6x57	kop_on	0	0.77	No	No	No	No	5	4
442	1x47	1x51	kop_on	0	0.75	No	No	No	No	6	4
443	5x68	I3.L258	kop_on	0	0.745	No	No	No	No	6	5
444	E2.D206	E2.V207	kop_on	0	0.73	No	No	No	No	3	3
445	7x41	Lig	kop_on	0	0.71	No	No	Yes	Yes	7	0
446	6x46	6x47	kop_on	0	0.4275	No	No	No	No	6	8
447	1x37	1x40	kop_on	0	0.4275	No	No	No	No	5	4
448	1x40	1x41	kop_on	0	0.405	No	No	No	No	4	5
449	I2x51	I2x52	kop_on	0	0.38	No	No	No	No	5	4
450	4x59	4x63	kop_on	0	0.375	No	No	No	No	7	4
451	4x41	I2x55	kop_on	0	0.345	No	No	No	No	5	4

Orange: nodes, hubs and links specific of kop_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of kop_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	kop_off Avg Int. Strength	kop_on Avg Int. Strength	kop_off Num Of Links	kop_on Num Of Links	ConSurf
1	1x54	kop_off	3.09	5.6	4	1	7
2	2x41	kop_off	3.034	3.12167	5	3	5
3	2x45	kop_off	9.602	10.9112	5	2	9
4	2x56	kop_off	4.215	3.11	4	3	7
5	2x57	kop_off	7.902	6.07333	5	3	7
6	3x38	kop_off	7.08	6.28083	4	3	7
7	3x41	kop_off	4.205	3.28375	4	2	6
8	3x50	kop_off	6.68167	7.46	6	2	9
9	4x50	kop_off	9.795	9.38333	4	3	9
10	4x56	kop_off	4.3675	5.2325	4	2	5
11	5x35	kop_off	8.56	11.6463	4	2	7
12	5x40	kop_off	7.38	5.04583	4	3	4
13	6x44	kop_off	9.378	5.54625	5	2	9
14	7x45	kop_off	7.86	8.51417	4	3	9
15	8x48	kop_off	5.865	3.81917	4	3	4
16	1x43	Shared	4.2125	4.36188	4	4	7
17	2x42	Shared	6.522	4.86071	5	7	7
18	E1x50	Shared	9.60167	7.73167	6	6	8
19	E1x52	Shared	11.062	6.26042	5	6	7
20	3x34	Shared	7.2475	5.51562	4	4	5
21	3x51	Shared	6.876	7.26062	5	4	7
22	E2.F214	Shared	6.828	3.049	5	5	6
23	5x47	Shared	7.4275	5.465	4	4	8
24	5x58	Shared	8.7825	6.579	4	5	8
25	6x48	Shared	7.42375	7.31125	8	4	8
26	7x38	Shared	6.96	5.08563	4	4	5
27	7x42	Shared	10.5725	6.374	4	5	6
28	7x49	Shared	6.8425	5.577	4	5	9
29	7x53	Shared	7.1775	4.69375	4	6	9
30	8x50	Shared	7.30667	5.0985	6	5	8
31	Lig	Shared	9.20231	8.5653	13	25	0
32	1x42	kop_on	4.74667	3.18625	3	4	7
33	2x46	kop_on	5.805	4.463	2	5	9
34	2x50	kop_on	6.98333	6.1235	3	5	9
35	2x59	kop_on	10.93	5.4625	2	4	5
36	2x60	kop_on	6.87667	6.71187	3	4	7
37	2x64	kop_on	6.63	7.89	2	4	4
38	3x26	kop_on	2.77	2.8125	1	4	6
39	3x37	kop_on	7.26333	4.99438	3	4	6
40	3x45	kop_on	4.435	4.48625	2	4	6
41	E2.R202	kop_on	7.51	3.78375	3	4	2
42	E2.E209	kop_on	14.215	4.40625	2	4	3
43	5x44	kop_on	7.73667	6.69125	3	4	5
44	I3.L259	kop_on	1.5	2.812	1	5	3
45	6x49	kop_on	4.005	3.63063	2	4	5
46	6x52	kop_on	8.44	5.62188	3	4	8
47	7x35	kop_on	8.69333	11.1031	3	4	4
48	7x52	kop_on	2.98	2.39437	2	4	8

Orange: nodes, hubs and links specific of kop_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of kop_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	kop_off Recurrence	kop_on Recurrence	kop_off Hub1?	kop_on Hub1?	kop_off Hub2?	kop_on Hub2?	ConSurf1	ConSurf2
1	1x38	1x42	kop_off	11.8219	1.19564	No	No	No	Yes	5	7
2	1x34	1x38	kop_off	10.3731	0	No	No	No	No	5	5
3	1x42	7x47	kop_off	11.8219	5.93614	No	Yes	No	No	7	7
4	6x48	Lig	kop_off	79.6917	0	Yes	Yes	Yes	Yes	8	0
5	1x52	8x54	kop_off	14.9469	0	No	No	No	No	6	6
6	8x50	8x54	kop_off	17.8361	0	Yes	Yes	No	No	8	6
7	2x43	7x53	kop_off	35.0699	0	No	No	Yes	Yes	8	9
8	1x52	8x57	kop_off	13.4897	0	No	No	No	No	6	4
9	2x48	4x50	kop_off	10.9628	0	No	No	Yes	No	6	9
10	2x45	4x49	kop_off	97.6078	0	Yes	No	No	No	9	7
11	3x41	4x49	kop_off	100	2.252	Yes	No	No	No	6	7
12	3x37	3x41	kop_off	41.6189	0	No	Yes	Yes	No	6	6
13	3x37	4x56	kop_off	41.2315	2.06806	No	Yes	Yes	No	6	5
14	3x33	4x56	kop_off	42.7729	0	No	No	Yes	No	5	5
15	3x33	Lig	kop_off	43.2488	1.00907	No	No	Yes	Yes	5	0
16	3x40	3x41	kop_off	62.8327	0	No	No	Yes	No	7	6
17	3x40	6x44	kop_off	66.5179	5.39745	No	No	Yes	No	7	9
18	6x44	6x48	kop_off	61.1734	6.4617	Yes	No	Yes	Yes	9	8
19	1x57	8x50	kop_off	22.6541	0	No	No	Yes	Yes	7	8
20	3x50	6x37	kop_off	22.5615	0	Yes	No	No	No	9	8
21	3x46	6x37	kop_off	63.2202	0	No	No	No	No	8	8
22	2x41	4x46	kop_off	27.2785	8.64013	Yes	No	No	No	5	7
23	2x41	4x42	kop_off	10.8406	0	Yes	No	No	No	5	7
24	2x42	4x42	kop_off	10.7564	1.12732	Yes	Yes	No	No	7	7
25	7x38	Lig	kop_off	16.7242	0.990671	Yes	Yes	Yes	Yes	5	0
26	7x34	7x38	kop_off	23.2311	0.186572	No	No	Yes	Yes	4	5
27	2x66	E1x51	kop_off	46.5423	2.2704	No	No	No	No	4	1
28	E1x51	E1x52	kop_off	49.0482	4.53817	No	No	Yes	Yes	1	7
29	E1x49	E2.V207	kop_off	21.02	0	No	No	No	No	4	3
30	2x66	E1x49	kop_off	44.028	0	No	No	No	No	4	4
31	3x28	E1x50	kop_off	32.9009	0	No	No	Yes	Yes	6	8
32	3x28	Lig	kop_off	34.017	8.27487	No	No	Yes	Yes	6	0
33	3x22	E2.T199	kop_off	13.1991	9.22612	No	No	No	No	2	4
34	E2.I208	E2.T199	kop_off	15.8145	0	No	No	No	No	4	4
35	E1x49	E2.I208	kop_off	21.02	1.16673	No	No	No	No	4	4
36	5x58	6x37	kop_off	40.625	0.867166	Yes	Yes	No	No	8	8
37	3x51	5x61	kop_off	24.861	0	Yes	Yes	No	No	7	8
38	3x51	5x64	kop_off	10.5037	0	Yes	Yes	No	No	7	5
39	2x41	4x39	kop_off	11.8977	0	Yes	No	No	No	5	2
40	5x32	E2.F214	kop_off	21.8918	0	No	No	Yes	Yes	1	6
41	5x32	5x36	kop_off	26.0487	0	No	No	No	No	1	4
42	E2.R202	E2.V205	kop_off	13.1991	0	No	Yes	No	No	2	1
43	E2.V205	E2.V207	kop_off	15.8145	0	No	No	No	No	1	3
44	5x35	E2.F214	kop_off	13.237	4.67218	Yes	No	Yes	Yes	7	6
45	5x47	6x52	kop_off	21.8287	5.80213	Yes	Yes	No	Yes	8	8
46	6x27	6x30	kop_off	10.3689	0	No	No	No	No	3	6
47	3x50	6x30	kop_off	12.2978	0	Yes	No	No	No	9	6
48	8x48	8x49	kop_off	10.3479	0	Yes	No	No	No	4	6
49	8x47	8x49	kop_off	11.8219	1.12732	No	No	No	No	8	6
50	8x47	8x50	kop_off	17.6255	2.252	No	No	Yes	Yes	8	8
51	6x48	6x51	kop_off	19.9587	0	Yes	Yes	No	No	8	6
52	6x51	6x55	kop_off	13.3465	0.0919721	No	No	No	No	6	5
53	6x54	7x34	kop_off	11.6745	2.31244	No	No	No	No	5	4
54	1x57	I1x51	kop_off	22.1782	0	No	No	No	No	7	7
55	E1x50	E1x52	kop_off	58.5622	5.58402	Yes	Yes	Yes	Yes	8	7
56	2x41	I1x51	kop_off	21.3191	0	Yes	No	No	No	5	7
57	1x42	2x57	Shared	24.482	11.7435	No	Yes	Yes	No	7	7
58	2x50	7x49	Shared	12.9001	15.7246	No	Yes	Yes	Yes	9	9
59	7x45	7x49	Shared	40.3344	98.983	Yes	No	Yes	Yes	9	9
60	6x48	7x45	Shared	36.0091	100	Yes	Yes	Yes	No	8	9
61	7x42	Lig	Shared	33.0231	20.8146	Yes	Yes	Yes	Yes	6	0
62	2x57	7x42	Shared	33.7727	18.539	Yes	No	Yes	Yes	7	6
63	2x43	8x50	Shared	34.7161	19.0225	No	No	Yes	Yes	8	8
64	7x49	7x53	Shared	33.8149	90.4743	Yes	Yes	Yes	Yes	9	9
65	2x45	4x50	Shared	26.6552	15.3383	Yes	No	Yes	No	9	9
66	2x42	4x46	Shared	67.9372	25.4158	Yes	Yes	No	No	7	7
67	2x45	4x46	Shared	77.9523	16.3947	Yes	No	No	No	9	7
68	2x42	3x46	Shared	65.0691	46.5484	Yes	Yes	No	No	7	8
69	E1x50	E2x50	Shared	32.9894	10.8974	Yes	Yes	No	No	8	9
70	E2x50	Lig	Shared	35.4195	22.88	No	No	Yes	Yes	9	0
71	3x34	4x50	Shared	14.551	11.0288	Yes	Yes	Yes	No	5	9
72	6x48	6x52	Shared	16.421	53.286	Yes	Yes	No	Yes	8	8
73	3x47	5x58	Shared	10.5037	12.8183	No	No	Yes	Yes	9	8
74	5x58	5x61	Shared	26.8784	29.4495	Yes	Yes	No	No	8	8
75	5x36	5x40	Shared	28.1755	16.371	No	No	Yes	No	4	4
76	5x40	6x55	Shared	38.6877	18.581	Yes	No	No	No	4	5
77	6x55	Lig	Shared	28.1418	19.4271	No	No	Yes	Yes	5	0
78	3x36	Lig	kop_on	7.59771	48.3511	No	No	Yes	Yes	7	0
79	3x36	6x48	kop_on	0.576988	49.3155	No	No	Yes	Yes	7	8
80	6x52	Lig	kop_on	0	51.8828	No	Yes	Yes	Yes	8	0
81	3x46	7x53	kop_on	0	62.5384	No	No	Yes	Yes	8	9
82	2x43	3x46	kop_on	0	20.0631	No	No	No	No	8	8
83	2x42	3x45	kop_on	0	15.9742	Yes	Yes	No	Yes	7	6
84	2x50	7x46	kop_on	1.63831	11.1812	No	Yes	No	No	9	8
85	3x25	E2x50	kop_on	1.31823	11.1129	No	No	No	No	9	9
86	3x25	E2.T199	kop_on	0	10.3561	No	No	No	No	9	4
87	3x45	3x48	kop_on	2.11422	11.8907	No	Yes	No	No	6	6
88	3x50	7x53	kop_on	0	47.0897	Yes	No	Yes	Yes	9	9
89	3x50	5x58	kop_on	0	46.438	Yes	No	Yes	Yes	9	8
90	3x47	5x57	kop_on	0	11.9038	No	No	No	No	9	7
91	3x51	5x57	kop_on	2.11422	10.8264	Yes	Yes	No	No	7	7
92	3x48	3x52	kop_on	0	10.8133	No	No	No	No	6	5
93	3x54	5x61	kop_on	0	28.4641	No	No	No	No	8	8
94	3x54	5x65	kop_on	2.11422	27.4655	No	No	No	No	8	8
95	5x36	E2.F214	kop_on	0	11.8933	No	No	Yes	Yes	4	6
96	E2.E209	Lig	kop_on	0	20.7647	No	Yes	Yes	Yes	3	0
97	E2.E209	E2.R202	kop_on	5.30239	14.6998	No	Yes	No	Yes	3	2
98	5x65	I3.L259	kop_on	0	25.7154	No	No	No	Yes	8	3
99	6x29	I3.L259	kop_on	0	15.4172	No	No	No	Yes	5	3

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x31	kop_off	4.56	0	1	0	1	2
2x56	7x42	Shared	4.99	3.1225	1	0	1	1
2x56	Lig	kop_off	5.74	0	1	0	1	0
2x57	7x42	Shared	17.96	9.5775	1	0	2	1
2x60	7x38	Shared	5.49	3.085	1	1	1	1
2x60	7x42	Shared	5.64	9.5825	1	1	1	1
2x60	Lig	Shared	9.5	9.9525	1	1	1	0
2x64	7x35	Shared	10.92	24.8225	0	0	2	2
3x25	E1x50	Shared	5.22	6.8575	1	1	2	2
3x28	E1x50	kop_off	7.36	0	0	1	1	2
E1x50	E2x50	Shared	23.51	16.6475	1	1	2	1
3x25	E2x50	Shared	7.28	7.28	1	1	2	1
3x28	Lig	Shared	3.87	3.6825	0	1	1	0
3x32	Lig	Shared	33.47	16.065	0	1	1	0
3x33	4x56	kop_off	5.05	0	0	0	1	2
3x33	Lig	Shared	6.09	7.44	0	0	1	0
3x35	6x48	kop_off	4.52	0	0	0	2	1
3x36	6x48	Shared	6.98	4.0725	1	1	1	1
3x36	6x52	kop_off	5.25	0	1	1	1	1
3x36	Lig	Shared	11.01	8.6425	1	1	1	0
3x37	4x56	Shared	9.18	8.85	0	0	2	2
E2.E209	E2.K200	Shared	12.15	3.7125	0	1	1	2
E2.E209	E2.R202	Shared	16.28	6.1075	0	1	1	2
E2x50	Lig	Shared	4.12	4.5175	1	1	1	0
5x32	E2x51	kop_off	3.82	0	0	1	1	2
5x32	E2.F214	kop_off	12.38	0	0	1	1	2
5x32	5x36	kop_off	12.64	0	0	1	1	2
5x36	5x40	Shared	16.59	7.6025	0	0	2	2
5x40	6x55	Shared	7.27	4.725	0	0	2	1
5x40	6x58	kop_off	4.05	0	0	0	2	1
5x43	Lig	Shared	8.7	4.995	0	1	1	0
5x47	6x52	Shared	15.84	5.0925	0	1	2	1
6x44	6x48	Shared	22.05	8.265	1	0	2	1
6x44	7x45	kop_off	7.25	0	1	0	2	2
6x48	6x51	kop_off	4.7	0	1	0	1	1
6x48	6x52	Shared	4.23	4.76	1	0	1	1
6x48	7x41	kop_off	4.22	0	1	0	1	1
6x48	7x45	Shared	6.78	12.1475	1	0	1	2
6x48	Lig	kop_off	5.91	0	1	0	1	0
6x51	6x55	Shared	4.42	4.05	0	1	1	1
6x51	7x38	kop_off	4.42	0	0	1	1	1
6x54	7x34	Shared	7.22	8.51	0	0	2	1
6x54	7x37	kop_off	4.19	0	0	0	2	2
6x55	Lig	Shared	10.19	10.66	0	1	1	0
7x31	7x35	Shared	8.21	4.1025	0	1	1	2
7x34	7x35	kop_off	6.95	0	0	1	1	2
7x34	7x38	Shared	13.3	7.855	0	1	1	1
7x38	Lig	Shared	4.63	6.075	1	1	1	0
7x42	Lig	Shared	13.7	6.26	1	1	1	0
3x29	Lig	Shared	2.7	8.5975	0	0	1	0
5x44	5x47	Shared	2.14	8.3075	0	1	2	2
7x40	7x41	kop_off	1.71	0	0	0	2	1
2x55	2x56	Shared	1.57	0.785	0	0	2	1
2x56	3x32	kop_on	0	5.4225	1	0	1	1
2x59	E1x50	kop_on	0	3.51	0	1	2	2
2x59	3x28	kop_on	0	7.535	0	1	2	1
3x31	3x35	kop_on	0	3.54	0	0	2	2
3x36	3x37	kop_on	0	3.7325	1	1	1	2
3x37	5x43	kop_on	0	3.93	0	0	2	1
E2.E209	E2x51	kop_on	0	4.31	0	1	1	2
E2.E209	Lig	kop_on	0	3.495	0	1	1	0
5x36	E2.F214	kop_on	0	6.2675	0	0	2	2
5x32	Lig	kop_on	0	6.1725	0	1	1	0
5x44	6x52	kop_on	0	8.7675	0	1	2	1
6x51	7x37	kop_on	0	3.2725	0	1	1	2
6x54	6x58	kop_on	0	8.745	0	0	2	1
6x58	Lig	kop_on	0	6.3625	0	1	1	0
7x31	Lig	kop_on	0	7.3075	0	1	1	0
7x34	Lig	kop_on	0	13.0375	0	1	1	0
7x38	7x42	kop_on	0	3.3275	1	1	1	1
6x51	Lig	kop_on	0	3.6925	0	1	1	0
6x52	Lig	kop_on	0	3.8675	1	1	1	0
5x31	5x32	kop_on	0	5.46	0	0	2	1
2x60	2x64	kop_on	0	4.2275	1	1	1	2
7x27	Lig	kop_on	0	3.41	0	0	1	0
7x30	Lig	kop_on	0	2.68	0	0	1	0
E3.T302	Lig	kop_on	0	2.065	0	0	1	0
E3.S303	Lig	kop_on	0	1.89	0	0	1	0
7x41	Lig	kop_on	0	0.71	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	kop_off	4DJH-κ-JDTic
	kop_on	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2

Network Difference
Value	kop_off	kop_on
I_min	3.77	2.95
Number of Linked Nodes	267	283
Number of Specific Nodes	11 (4.12%)	27 (9.54%)
Number of Shared Nodes	256 (95.88%)	256 (90.46%)
Number of Links	283	306
Number of Specific Links	145 (51.24%)	168 (54.90%)
Number of Shared Links	138 (48.76%)	138 (45.10%)
Number of Hubs	31	33
Number of Specific Hubs	15 (48.39%)	17 (51.52%)
Number of Shared Hubs	16 (51.61%)	16 (48.48%)
Average % Shared Neighbours (Jaccard)	31.10
Average % Shared Neighbours (Otsuka)	39.73
Average % Shared Neighbours (Overlap Coefficient)	48.02
Average % Shared Cliques (k3-6)	52.68
Graphlets Similarity	0.5007

Paths Difference
Value	kop_off	kop_on
Number Of Nodes in MetaPath	73	43
Specific Nodes in MetaPath	42 (57.53%)	12 (27.91%)
Shared Nodes in MetaPath	256 (95.88%)	256 (95.88%)
Number Of Links MetaPath	77	43
Specific Links in MetaPath	56 (72.73%)	22 (51.16%)
Shared Links in MetaPath	138 (48.76%)	138 (48.76%)
Number of Shortest Paths	56638	61233
Length Of Smallest Path	3	3
Average Path Length	13.5668	12.9457
Length of Longest Path	28	29
Minimum Path Strength	1.19	0.41625
Average Path Strength	7.49318	5.67666
Maximum Path Strength	23.585	15.465
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.926981	0.911351
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.16667	4.16667
Average % Of Corr. Nodes	51.1717	40.9096
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	42.6738	42.2003
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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