psnGPCR

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Orange: nodes, hubs and links specific of lpa1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of lpa1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	lpa1_off Int. Strength	lpa1_on Int. Strength	lpa1_off Hub1?	lpa1_on Hub1?	lpa1_off Hub2?	lpa1_on Hub2?	ConSurf1	ConSurf2
1	E2.I192	NT.Q23	lpa1_off	100	0	No	No	No	No	1	3
2	E2.I189	NT.F25	lpa1_off	100	0	No	Yes	No	Yes	3	7
3	NT.E28	NT.Y26	lpa1_off	100	0	No	No	No	No	4	4
4	NT.I30	NT.Y34	lpa1_off	100	0	No	No	Yes	Yes	6	6
5	3x25	NT.Y34	lpa1_off	100	0	Yes	Yes	Yes	Yes	9	6
6	NT.H40	NT.K39	lpa1_off	100	0	No	No	Yes	No	2	8
7	E1x501	NT.T43	lpa1_off	100	0	No	No	No	No	6	3
8	1x39	2x61	lpa1_off	100	0	No	No	No	No	6	6
9	1x42	7x42	lpa1_off	100	0	No	No	Yes	No	7	7
10	1x52	8x57	lpa1_off	100	0	No	No	No	No	7	6
11	8x49	I1x49	lpa1_off	100	0	No	No	No	No	7	6
12	2x38	I2x53	lpa1_off	100	0	Yes	Yes	No	No	6	4
13	2x39	3x50	lpa1_off	100	0	No	No	Yes	No	8	9
14	2x40	6x33	lpa1_off	100	0	Yes	No	No	No	9	7
15	2x42	3x46	lpa1_off	100	0	No	No	No	No	8	8
16	2x45	4x49	lpa1_off	100	0	Yes	No	Yes	No	9	7
17	2x46	7x49	lpa1_off	100	0	Yes	Yes	Yes	No	9	9
18	2x59	3x27	lpa1_off	100	0	No	No	No	No	5	4
19	2x63	E1x52	lpa1_off	100	0	No	No	No	No	5	6
20	E1x48	E1x49	lpa1_off	100	0	No	No	No	No	4	4
21	3x32	Lig	lpa1_off	100	0	No	No	Yes	Yes	6	0
22	3x33	5x43	lpa1_off	100	0	Yes	Yes	Yes	Yes	5	6
23	3x36	5x43	lpa1_off	100	0	No	No	Yes	Yes	7	6
24	3x36	5x47	lpa1_off	100	0	No	No	Yes	Yes	7	7
25	3x43	6x41	lpa1_off	100	0	No	Yes	No	No	8	7
26	3x43	6x44	lpa1_off	100	0	No	Yes	Yes	Yes	8	9
27	3x50	3x53	lpa1_off	100	0	Yes	No	No	No	9	8
28	3x50	6x30	lpa1_off	100	0	Yes	No	No	Yes	9	7
29	3x50	6x33	lpa1_off	100	0	Yes	No	No	No	9	7
30	3x50	6x34	lpa1_off	100	0	Yes	No	No	No	9	7
31	6x26	I2x51	lpa1_off	100	0	No	No	No	No	4	4
32	4x38	I2x53	lpa1_off	100	0	No	No	No	No	8	4
33	4x41	I2x56	lpa1_off	100	0	No	No	No	No	6	6
34	5x42	E2.W186	lpa1_off	100	0	No	No	No	No	6	6
35	E2.D191	E2.N194	lpa1_off	100	0	No	No	No	No	4	3
36	5x40	E2.S196	lpa1_off	100	0	No	No	No	No	6	5
37	E2.M198	Lig	lpa1_off	100	0	Yes	No	Yes	Yes	3	0
38	5x39	5x43	lpa1_off	100	0	Yes	Yes	Yes	Yes	7	6
39	5x58	6x41	lpa1_off	100	0	Yes	Yes	No	No	9	7
40	6x40	7x49	lpa1_off	100	0	No	No	Yes	No	8	9
41	6x40	7x52	lpa1_off	100	0	No	No	No	No	8	8
42	6x44	7x45	lpa1_off	100	0	Yes	Yes	Yes	No	9	9
43	6x48	Lig	lpa1_off	100	0	Yes	Yes	Yes	Yes	8	0
44	6x54	7x31	lpa1_off	100	0	No	No	No	No	4	3
45	6x57	6x61	lpa1_off	100	0	No	No	No	No	5	4
46	6x58	7x31	lpa1_off	100	0	No	Yes	No	No	4	3
47	7x29	7x33	lpa1_off	100	0	No	No	No	No	1	3
48	7x45	7x48	lpa1_off	100	0	Yes	No	No	No	9	6
49	8x47	8x50	lpa1_off	100	0	No	No	No	No	8	8
50	I1x48	I1x51	lpa1_off	100	0	No	No	No	No	6	8
51	1x53	8x54	lpa1_off	50	0	No	No	Yes	Yes	9	6
52	3x44	5x54	lpa1_off	75	0	No	No	No	No	7	9
53	1x45	1x49	lpa1_off	50	0	No	No	No	No	4	8
54	1x55	8x57	lpa1_off	50	0	No	No	No	No	5	6
55	2x42	4x42	lpa1_off	50	0	No	No	No	No	8	7
56	5x48	6x49	lpa1_off	75	0	No	No	No	No	5	5
57	2x43	6x33	lpa1_off	75	0	No	No	No	No	8	7
58	6x47	7x40	lpa1_off	0	0	No	No	No	No	9	7
59	5x58	6x38	lpa1_off	75	0	Yes	Yes	No	No	9	5
60	1x57	I1x50	lpa1_off	25	0	No	No	Yes	Yes	7	8
61	6x39	7x56	lpa1_off	50	0	No	No	Yes	Yes	6	7
62	2x37	I2x52	lpa1_off	50	0	No	No	No	No	7	8
63	2x61	7x42	lpa1_off	75	0	No	No	Yes	No	6	7
64	3x26	4x61	lpa1_off	25	0	No	No	No	No	5	6
65	7x54	8x54	lpa1_off	75	0	No	No	Yes	Yes	7	6
66	1x56	8x53	lpa1_off	0	0	No	No	No	No	7	7
67	4x40	I2x55	lpa1_off	25	0	Yes	No	No	No	5	3
68	2x38	4x39	lpa1_off	50	0	Yes	Yes	No	No	6	3
69	1x45	7x51	lpa1_off	50	0	No	No	No	No	4	7
70	6x27	6x31	lpa1_off	25	0	No	No	No	No	4	5
71	3x47	5x57	lpa1_off	0	0	No	No	No	No	8	6
72	6x30	I2x51	lpa1_off	25	0	No	Yes	No	No	7	4
73	I2x54	I2x56	lpa1_off	25	0	No	No	No	No	4	6
74	2x46	3x39	lpa1_off	0	0	Yes	Yes	No	No	9	9
75	2x49	3x39	lpa1_off	0	0	No	No	No	No	8	9
76	2x56	3x32	lpa1_off	25	0	No	No	No	No	5	6
77	NT.N27	NT.Y26	lpa1_off	25	0	No	No	No	No	8	4
78	4x45	4x49	lpa1_off	0	0	No	No	Yes	No	6	7
79	5x37	E2.S196	lpa1_off	0	0	No	No	No	No	4	5
80	3x22	E2.L201	lpa1_off	0	0	No	No	No	No	2	1
81	1x36	1x40	lpa1_off	0	0	No	No	Yes	Yes	4	4
82	3x41	4x52	lpa1_off	25	0	No	No	No	No	5	4
83	7x39	7x42	lpa1_off	0	0	No	No	Yes	No	6	7
84	NT.F32	NT.S29	lpa1_off	25	0	Yes	Yes	No	No	2	4
85	4x40	4x43	lpa1_off	50	0	Yes	No	No	No	5	1
86	1x54	2x51	lpa1_off	0	0	No	No	No	Yes	7	7
87	E1.T109	E1x47	lpa1_off	0	0	No	No	No	No	5	5
88	1x36	1x37	lpa1_off	25	0	No	No	No	No	4	4
89	1x54	2x47	lpa1_off	0	0	No	No	No	No	7	9
90	6x49	6x53	lpa1_off	0	0	No	No	No	No	5	6
91	1x58	1x59	lpa1_off	0	0	No	No	No	No	3	5
92	4x40	I2x56	lpa1_off	25	0	Yes	No	No	No	5	6
93	6x32	6x35	lpa1_off	25	0	No	No	No	No	7	7
94	1x44	1x48	lpa1_off	0	0	No	No	No	No	4	4
95	E3.C287	E3.P285	lpa1_off	0	0	No	No	No	No	5	3
96	5x37	E2.N194	lpa1_off	25	0	No	No	No	No	4	3
97	E2.C195	NT.S37	lpa1_off	0	0	No	No	No	No	9	7
98	4x58	4x62	lpa1_off	0	0	No	No	No	No	4	5
99	4x63	E2.N187	lpa1_off	0	0	No	No	No	No	5	6
100	7x35	7x36	lpa1_off	0	0	No	No	No	No	4	4
101	4x47	4x51	lpa1_off	0	0	No	No	No	No	4	3
102	5x61	5x65	lpa1_off	0	0	No	No	No	No	9	7
103	5x65	6x31	lpa1_off	0	0	No	No	No	No	7	5
104	I2x50	I2x51	lpa1_off	25	0	No	No	No	No	7	4
105	5x49	5x50	lpa1_off	0	0	No	No	No	No	4	7
106	NT.E21	NT.P22	lpa1_off	0	0	No	No	No	No	0	0
107	NT.A42	NT.E44	lpa1_off	0	0	No	No	No	No	4	1
108	3x52	3x56	lpa1_off	0	0	No	No	No	No	5	5
109	8x58	8x59	lpa1_off	0	0	No	No	No	No	6	4
110	5x49	5x52	lpa1_off	0	0	No	No	No	No	4	3
111	6x32	8x48	lpa1_off	0	0	No	No	No	No	7	5
112	8x52	8x56	lpa1_off	0	0	No	No	No	No	4	4
113	NT.F32	NT.P22	lpa1_off	0	0	Yes	Yes	No	No	2	0
114	8x52	8x55	lpa1_off	0	0	No	No	No	No	4	4
115	6x25	6x26	lpa1_off	0	0	No	No	No	No	4	4
116	NT.N35	NT.Y34	lpa1_off	0	0	No	No	Yes	Yes	7	6
117	E2.C190	NT.C24	Shared	100	100	No	No	No	No	3	5
118	NT.E28	NT.F32	Shared	100	100	No	No	Yes	Yes	4	2
119	NT.F32	NT.F33	Shared	100	100	Yes	Yes	No	No	2	6
120	NT.F32	NT.R36	Shared	100	100	Yes	Yes	No	No	2	3
121	E2.L201	NT.F33	Shared	100	100	No	No	No	No	1	6
122	NT.K39	NT.Y34	Shared	100	100	Yes	No	Yes	Yes	8	6
123	NT.L41	NT.Y34	Shared	100	100	No	Yes	Yes	Yes	2	6
124	E1x50	NT.Y34	Shared	100	100	No	No	Yes	Yes	5	6
125	E2.P200	NT.Y34	Shared	100	100	No	No	Yes	Yes	6	6
126	E2.I192	NT.R36	Shared	100	100	No	No	No	No	1	3
127	7x34	NT.K39	Shared	100	100	No	Yes	Yes	No	4	8
128	E1x501	NT.L41	Shared	100	100	No	No	No	Yes	6	2
129	1x33	NT.W45	Shared	100	0	No	No	Yes	Yes	3	1
130	E1x48	NT.W45	Shared	100	100	No	No	Yes	Yes	4	1
131	E1x49	NT.W45	Shared	100	0	No	No	Yes	Yes	4	1
132	1x31	NT.N46	Shared	100	100	No	No	Yes	Yes	3	2
133	1x32	NT.N46	Shared	100	100	No	No	Yes	Yes	1	2
134	1x40	2x58	Shared	100	100	Yes	Yes	No	No	4	6
135	1x43	2x58	Shared	100	100	No	No	No	No	6	6
136	1x46	1x50	Shared	100	100	No	Yes	Yes	Yes	8	9
137	1x46	7x46	Shared	100	100	No	Yes	No	No	8	9
138	1x47	2x51	Shared	100	100	No	No	No	Yes	6	7
139	1x47	2x55	Shared	100	100	No	No	No	No	6	4
140	1x49	7x50	Shared	100	100	No	No	No	No	8	9
141	1x50	2x47	Shared	100	100	Yes	Yes	No	No	9	9
142	1x50	2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
143	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
144	1x51	2x51	Shared	100	100	No	No	No	Yes	4	7
145	1x52	8x54	Shared	100	100	No	No	Yes	Yes	7	6
146	1x60	I1x50	Shared	100	100	No	No	Yes	Yes	6	8
147	1x60	8x53	Shared	100	100	No	No	No	No	6	7
148	2x40	I1x50	Shared	100	100	Yes	No	Yes	Yes	9	8
149	8x49	I1x50	Shared	100	0	No	No	Yes	Yes	7	8
150	8x50	I1x50	Shared	100	100	No	No	Yes	Yes	8	8
151	2x41	I1x51	Shared	100	100	No	No	No	No	4	8
152	2x38	3x49	Shared	100	100	Yes	Yes	No	No	6	8
153	2x39	2x40	Shared	100	100	No	No	Yes	No	8	9
154	2x39	3x49	Shared	100	100	No	No	No	No	8	8
155	2x40	8x47	Shared	100	100	Yes	No	No	No	9	8
156	2x41	4x39	Shared	100	100	No	No	No	No	4	3
157	2x43	7x53	Shared	100	50	No	No	No	Yes	8	9
158	2x45	3x42	Shared	100	100	Yes	No	No	Yes	9	8
159	2x45	4x46	Shared	100	100	Yes	No	No	No	9	8
160	2x45	4x50	Shared	100	100	Yes	No	No	No	9	9
161	2x46	3x42	Shared	100	100	Yes	Yes	No	Yes	9	8
162	2x46	3x43	Shared	100	100	Yes	Yes	No	Yes	9	8
163	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
164	2x50	7x49	Shared	100	100	No	Yes	Yes	No	9	9
165	2x52	3x34	Shared	100	100	Yes	Yes	No	No	7	6
166	2x52	4x50	Shared	100	100	Yes	Yes	No	No	7	9
167	2x57	7x38	Shared	100	100	No	Yes	No	No	7	6
168	2x57	7x42	Shared	100	100	No	Yes	Yes	No	7	7
169	2x59	2x63	Shared	100	100	No	No	No	No	5	5
170	2x60	3x28	Shared	100	100	No	Yes	Yes	Yes	6	6
171	2x60	3x32	Shared	100	100	No	Yes	No	No	6	6
172	E1.T109	Lig	Shared	100	100	No	No	Yes	Yes	5	0
173	E1x47	E1x48	Shared	100	100	No	No	No	No	5	4
174	3x24	E1x52	Shared	100	100	No	No	No	No	4	6
175	3x28	E1x52	Shared	100	100	Yes	Yes	No	No	6	6
176	3x21	3x23	Shared	100	100	No	No	No	No	6	1
177	3x21	3x24	Shared	100	100	No	No	No	No	6	4
178	3x25	3x28	Shared	100	100	Yes	Yes	Yes	Yes	9	6
179	3x25	3x29	Shared	100	100	Yes	Yes	Yes	Yes	9	4
180	3x25	E2.P200	Shared	100	100	Yes	Yes	No	No	9	6
181	3x25	E2.L201	Shared	100	100	Yes	Yes	No	No	9	1
182	3x25	E2.Y202	Shared	100	100	Yes	Yes	Yes	Yes	9	4
183	3x28	3x29	Shared	100	100	Yes	Yes	Yes	Yes	6	4
184	3x29	E2.Y202	Shared	100	100	Yes	Yes	Yes	Yes	4	4
185	3x29	Lig	Shared	100	100	Yes	Yes	Yes	Yes	4	0
186	3x33	E2.Y202	Shared	100	100	Yes	Yes	Yes	Yes	5	4
187	3x33	5x39	Shared	100	100	Yes	Yes	Yes	Yes	5	7
188	3x33	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
189	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	8
190	3x37	4x56	Shared	100	100	No	No	No	Yes	6	5
191	3x37	5x43	Shared	100	100	No	No	Yes	Yes	6	6
192	3x38	4x50	Shared	100	100	No	No	No	No	7	9
193	3x40	5x47	Shared	100	100	No	Yes	Yes	Yes	8	7
194	3x40	5x50	Shared	100	100	No	Yes	No	No	8	7
195	3x41	4x49	Shared	100	100	No	No	Yes	No	5	7
196	3x42	4x49	Shared	100	100	No	Yes	Yes	No	8	7
197	3x47	5x58	Shared	100	100	No	No	Yes	Yes	8	9
198	3x51	3x55	Shared	100	100	Yes	Yes	No	Yes	7	6
199	3x51	5x57	Shared	100	100	Yes	Yes	No	No	7	6
200	3x51	5x60	Shared	100	100	Yes	Yes	No	No	7	5
201	3x51	5x61	Shared	100	100	Yes	Yes	No	No	7	9
202	3x54	5x61	Shared	100	100	No	No	No	No	8	9
203	3x55	5x64	Shared	100	100	No	Yes	No	No	6	6
204	4x56	5x46	Shared	100	100	No	Yes	No	No	5	5
205	4x60	E2.Y202	Shared	100	100	No	No	Yes	Yes	6	4
206	4x60	5x39	Shared	100	100	No	No	Yes	Yes	6	7
207	5x38	E2.W186	Shared	100	100	No	No	No	No	5	6
208	5x39	E2.W186	Shared	100	100	Yes	Yes	No	No	7	6
209	E2.I189	E2.N187	Shared	100	100	No	Yes	No	No	3	6
210	E2.C188	E2.C195	Shared	100	100	No	No	No	No	5	9
211	6x58	E2.N197	Shared	100	100	No	Yes	No	No	4	5
212	6x54	E2.M198	Shared	100	100	No	No	Yes	No	4	3
213	6x58	E2.M198	Shared	100	100	No	Yes	Yes	No	4	3
214	7x34	E2.M198	Shared	100	100	No	Yes	Yes	No	4	3
215	5x39	E2.Y202	Shared	100	100	Yes	Yes	Yes	Yes	7	4
216	5x36	5x38	Shared	100	100	No	No	No	No	5	5
217	5x37	6x59	Shared	100	100	No	No	No	Yes	4	5
218	5x40	6x55	Shared	100	100	No	No	No	No	6	6
219	5x43	5x47	Shared	100	100	Yes	Yes	Yes	Yes	6	7
220	5x43	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
221	5x44	6x56	Shared	100	0	No	No	No	No	4	6
222	5x47	6x52	Shared	100	100	Yes	Yes	No	No	7	6
223	5x51	6x44	Shared	100	100	No	Yes	Yes	Yes	5	9
224	5x51	6x45	Shared	100	100	No	Yes	Yes	Yes	5	6
225	5x54	6x41	Shared	100	0	No	No	No	No	9	7
226	5x58	6x37	Shared	100	100	Yes	Yes	No	No	9	8
227	5x62	6x34	Shared	100	100	No	Yes	No	No	6	7
228	6x36	7x56	Shared	100	100	No	No	Yes	Yes	8	7
229	6x39	7x52	Shared	100	0	No	No	No	No	6	8
230	6x40	7x53	Shared	100	100	No	No	No	Yes	8	9
231	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
232	6x45	6x49	Shared	100	100	Yes	Yes	No	No	6	5
233	6x47	7x45	Shared	100	100	No	No	Yes	No	9	9
234	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
235	6x50	7x37	Shared	100	100	No	No	No	No	9	5
236	6x51	Lig	Shared	100	50	No	No	Yes	Yes	5	0
237	6x54	7x37	Shared	100	100	No	No	No	No	4	5
238	6x55	Lig	Shared	100	100	No	No	Yes	Yes	6	0
239	6x61	E3.C287	Shared	100	100	No	No	No	No	4	5
240	7x33	7x37	Shared	100	100	No	No	No	No	3	5
241	7x34	Lig	Shared	100	100	No	Yes	Yes	Yes	4	0
242	7x35	Lig	Shared	100	100	No	No	Yes	Yes	4	0
243	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
244	7x43	7x48	Shared	100	100	No	No	No	No	5	6
245	7x45	7x49	Shared	100	100	Yes	No	Yes	No	9	9
246	7x55	7x56	Shared	100	100	No	No	Yes	Yes	5	7
247	8x50	8x54	Shared	100	100	No	No	Yes	Yes	8	6
248	Lig	NT.K39	Shared	100	100	Yes	Yes	Yes	No	0	8
249	3x28	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
250	NT.F25	NT.Q23	Shared	100	50	No	Yes	No	No	7	3
251	2x38	4x42	Shared	25	100	Yes	Yes	No	No	6	7
252	1x36	2x62	Shared	25	100	No	No	No	No	4	5
253	2x53	3x35	Shared	25	100	No	No	No	No	8	6
254	1x35	7x35	Shared	25	100	No	No	No	No	5	4
255	6x35	7x56	Shared	25	0	No	No	Yes	Yes	7	7
256	4x59	4x60	Shared	25	100	No	No	No	No	5	6
257	2x52	3x35	Shared	25	100	Yes	Yes	No	No	7	6
258	2x37	2x38	Shared	75	100	No	No	Yes	Yes	7	6
259	5x41	6x59	Shared	25	100	No	No	No	Yes	4	5
260	3x34	4x57	Shared	25	0	No	No	No	No	6	7
261	1x46	2x54	Shared	25	100	No	Yes	No	No	8	7
262	4x55	4x59	Shared	0	100	No	No	No	No	4	5
263	E1x49	E1x51	Shared	25	100	No	No	No	No	4	3
264	E2.A199	E2.Y202	Shared	25	100	No	No	Yes	Yes	4	4
265	3x44	3x48	Shared	25	100	No	No	No	No	7	6
266	1x45	7x47	Shared	0	0	No	No	No	No	4	7
267	3x26	E2.N187	Shared	0	0	No	No	No	No	5	6
268	4x38	4x40	Shared	25	100	No	No	Yes	No	8	5
269	6x53	6x57	Shared	0	0	No	No	No	No	6	5
270	1x40	1x44	Shared	0	0	Yes	Yes	No	No	4	4
271	3x30	3x33	Shared	25	100	No	No	Yes	Yes	6	5
272	2x52	3x31	Shared	0	0	Yes	Yes	No	No	7	5
273	3x45	4x49	Shared	25	100	No	No	Yes	No	8	7
274	1x57	2x44	Shared	25	100	No	No	No	No	7	7
275	1x54	2x48	Shared	0	50	No	No	No	No	7	6
276	NT.G38	NT.S37	Shared	25	100	No	No	No	No	4	7
277	3x37	4x53	Shared	25	50	No	No	No	No	6	8
278	1x43	2x57	Shared	25	100	No	No	No	Yes	6	7
279	6x43	7x48	Shared	0	0	No	No	No	No	6	6
280	7x32	7x33	Shared	25	100	No	No	No	No	2	3
281	5x51	5x55	Shared	25	100	No	Yes	No	No	5	4
282	E2.E193	NT.R36	Shared	25	50	No	No	No	No	4	3
283	1x38	7x39	Shared	0	100	No	No	No	No	4	6
284	NT.E44	NT.N46	Shared	25	50	No	No	Yes	Yes	1	2
285	E2.I189	NT.C24	Shared	25	0	No	Yes	No	No	3	5
286	5x44	6x52	Shared	0	0	No	No	No	No	4	6
287	1x32	NT.W45	Shared	0	50	No	No	Yes	Yes	1	1
288	E2.N197	NT.S37	Shared	0	0	No	No	No	No	5	7
289	3x48	3x52	Shared	0	0	No	No	No	No	6	5
290	4x40	4x44	Shared	0	0	Yes	No	No	No	5	3
291	5x36	E2.C188	Shared	0	50	No	No	No	No	5	5
292	NT.A31	NT.S29	Shared	0	0	No	No	No	No	2	4
293	6x59	6x60	Shared	0	50	No	Yes	No	No	5	4
294	1x55	1x59	Shared	0	0	No	No	No	No	5	5
295	3x34	4x54	Shared	25	100	No	No	No	No	6	3
296	6x57	7x30	Shared	25	50	No	No	No	No	5	4
297	6x45	6x46	Shared	0	0	Yes	Yes	No	No	6	5
298	1x30	NT.N46	Shared	0	100	No	No	Yes	Yes	5	2
299	4x62	4x63	Shared	25	100	No	No	No	No	5	5
300	5x41	5x45	Shared	0	100	No	No	No	No	4	4
301	4x48	4x52	Shared	0	0	No	No	No	No	3	4
302	3x44	5x53	Shared	0	50	No	No	No	No	7	5
303	5x53	5x57	Shared	0	50	No	No	No	No	5	6
304	6x28	6x31	Shared	0	100	No	No	No	No	5	5
305	6x42	6x45	Shared	0	0	No	No	Yes	Yes	4	6
306	1x40	1x41	Shared	0	0	Yes	Yes	No	No	4	5
307	1x34	1x38	Shared	0	50	No	No	No	No	4	4
308	NT.F25	NT.N27	lpa1_on	0	100	No	Yes	No	No	7	8
309	NT.E28	NT.F25	lpa1_on	0	100	No	No	No	Yes	4	7
310	E2.I192	NT.F25	lpa1_on	0	100	No	No	No	Yes	1	7
311	E2.I189	NT.Y26	lpa1_on	0	100	No	Yes	No	No	3	4
312	NT.E28	NT.N27	lpa1_on	0	100	No	No	No	No	4	8
313	Lig	NT.Y34	lpa1_on	0	100	Yes	Yes	Yes	Yes	0	6
314	1x42	1x46	lpa1_on	0	100	No	No	No	Yes	7	8
315	1x42	7x39	lpa1_on	0	100	No	No	No	No	7	6
316	1x46	7x47	lpa1_on	0	100	No	Yes	No	No	8	7
317	1x53	1x57	lpa1_on	0	100	No	No	No	No	9	7
318	1x53	2x47	lpa1_on	0	100	No	No	No	No	9	9
319	1x59	1x60	lpa1_on	0	100	No	No	No	No	5	6
320	I1x49	I1x50	lpa1_on	0	100	No	No	Yes	Yes	6	8
321	8x53	I1x50	lpa1_on	0	100	No	No	Yes	Yes	7	8
322	2x38	I2x56	lpa1_on	0	100	Yes	Yes	No	No	6	6
323	2x41	4x42	lpa1_on	0	100	No	No	No	No	4	7
324	2x42	3x49	lpa1_on	0	100	No	No	No	No	8	8
325	2x46	2x50	lpa1_on	0	100	Yes	Yes	No	Yes	9	9
326	2x46	3x46	lpa1_on	0	100	Yes	Yes	No	No	9	8
327	2x50	3x39	lpa1_on	0	100	No	Yes	No	No	9	9
328	2x51	2x55	lpa1_on	0	100	No	Yes	No	No	7	4
329	2x56	3x35	lpa1_on	0	100	No	No	No	No	5	6
330	2x57	2x60	lpa1_on	0	100	No	Yes	No	Yes	7	6
331	2x57	2x61	lpa1_on	0	100	No	Yes	No	No	7	6
332	2x57	7x39	lpa1_on	0	100	No	Yes	No	No	7	6
333	2x58	2x62	lpa1_on	0	100	No	No	No	No	6	5
334	2x60	2x61	lpa1_on	0	100	No	Yes	No	No	6	6
335	2x63	3x28	lpa1_on	0	100	No	No	Yes	Yes	5	6
336	3x28	E1x50	lpa1_on	0	100	Yes	Yes	No	No	6	5
337	E1x50	Lig	lpa1_on	0	100	No	No	Yes	Yes	5	0
338	3x27	3x31	lpa1_on	0	100	No	No	No	No	4	5
339	3x36	7x42	lpa1_on	0	100	No	No	Yes	No	7	7
340	3x40	6x44	lpa1_on	0	100	No	Yes	Yes	Yes	8	9
341	3x40	6x48	lpa1_on	0	100	No	Yes	Yes	Yes	8	8
342	3x43	7x49	lpa1_on	0	100	No	Yes	Yes	No	8	9
343	3x43	7x53	lpa1_on	0	100	No	Yes	No	Yes	8	9
344	3x44	5x50	lpa1_on	0	100	No	No	No	No	7	7
345	3x46	3x50	lpa1_on	0	100	No	No	Yes	No	8	9
346	3x46	7x53	lpa1_on	0	100	No	No	No	Yes	8	9
347	3x50	5x58	lpa1_on	0	100	Yes	No	Yes	Yes	9	9
348	3x50	7x53	lpa1_on	0	100	Yes	No	No	Yes	9	9
349	3x53	3x56	lpa1_on	0	100	No	No	No	No	8	5
350	3x54	3x55	lpa1_on	0	100	No	No	No	Yes	8	6
351	3x55	5x60	lpa1_on	0	100	No	Yes	No	No	6	5
352	3x56	I2x54	lpa1_on	0	100	No	No	No	No	5	4
353	3x56	I2x56	lpa1_on	0	100	No	No	No	No	5	6
354	5x68	I2x50	lpa1_on	0	100	No	No	No	No	0	7
355	I2x51	I2x54	lpa1_on	0	100	No	No	No	No	4	4
356	I2x52	I2x53	lpa1_on	0	100	No	No	No	No	8	4
357	I2x54	I2x55	lpa1_on	0	100	No	No	No	No	4	3
358	4x56	5x42	lpa1_on	0	100	No	Yes	No	No	5	6
359	4x56	5x43	lpa1_on	0	100	No	Yes	Yes	Yes	5	6
360	4x59	E2.W186	lpa1_on	0	100	No	No	No	No	5	6
361	E2.I189	E2.L201	lpa1_on	0	100	No	Yes	No	No	3	1
362	6x58	E2.S196	lpa1_on	0	100	No	Yes	No	No	4	5
363	E2.Y202	Lig	lpa1_on	0	100	Yes	Yes	Yes	Yes	4	0
364	5x40	6x59	lpa1_on	0	100	No	No	No	Yes	6	5
365	5x43	6x48	lpa1_on	0	100	Yes	Yes	Yes	Yes	6	8
366	5x46	5x50	lpa1_on	0	100	No	No	No	No	5	7
367	5x47	6x44	lpa1_on	0	100	Yes	Yes	Yes	Yes	7	9
368	5x47	6x48	lpa1_on	0	100	Yes	Yes	Yes	Yes	7	8
369	5x55	6x41	lpa1_on	0	100	No	No	No	No	4	7
370	5x58	6x40	lpa1_on	0	100	Yes	Yes	No	No	9	8
371	5x62	6x30	lpa1_on	0	100	No	Yes	No	Yes	6	7
372	5x62	6x33	lpa1_on	0	100	No	Yes	No	No	6	7
373	5x64	5x68	lpa1_on	0	100	No	No	No	No	6	0
374	5x65	6x33	lpa1_on	0	100	No	No	No	No	7	7
375	5x66	6x30	lpa1_on	0	100	No	No	No	Yes	0	7
376	5x69	6x29	lpa1_on	0	100	No	No	No	No	0	5
377	6x28	6x30	lpa1_on	0	100	No	No	No	Yes	5	7
378	6x32	7x56	lpa1_on	0	100	No	No	Yes	Yes	7	7
379	6x39	7x55	lpa1_on	0	100	No	No	No	No	6	5
380	6x48	7x45	lpa1_on	0	100	Yes	Yes	Yes	No	8	9
381	6x49	6x50	lpa1_on	0	100	No	No	No	No	5	9
382	6x58	7x30	lpa1_on	0	100	No	Yes	No	No	4	4
383	6x61	E3.P285	lpa1_on	0	100	No	No	No	No	4	3
384	7x52	7x53	lpa1_on	0	100	No	No	No	Yes	8	9
385	7x54	8x50	lpa1_on	0	100	No	No	No	No	7	8
386	NT.F25	NT.F32	lpa1_on	0	100	No	Yes	Yes	Yes	7	2
387	1x50	2x51	lpa1_on	0	50	Yes	Yes	No	Yes	9	7
388	3x25	NT.I30	lpa1_on	0	50	Yes	Yes	No	No	9	6
389	2x42	4x46	lpa1_on	0	0	No	No	No	No	8	8
390	3x43	5x54	lpa1_on	0	0	No	Yes	No	No	8	9
391	1x56	8x54	lpa1_on	0	50	No	No	Yes	Yes	7	6
392	7x43	7x47	lpa1_on	0	0	No	No	No	No	5	7
393	1x37	1x40	lpa1_on	0	50	No	No	Yes	Yes	4	4
394	E2.E193	E2.N194	lpa1_on	0	0	No	No	No	No	4	3
395	3x52	4x41	lpa1_on	0	50	No	No	No	No	5	6
396	4x52	5x46	lpa1_on	0	0	No	No	No	No	4	5
397	6x50	7x40	lpa1_on	0	50	No	No	No	No	9	7
398	4x42	4x43	lpa1_on	0	50	No	No	No	No	7	1
399	2x49	3x42	lpa1_on	0	50	No	No	No	Yes	8	8
400	1x36	NT.W45	lpa1_on	0	50	No	No	Yes	Yes	4	1
401	5x62	5x63	lpa1_on	0	0	No	Yes	No	No	6	2
402	1x39	2x57	lpa1_on	0	0	No	No	No	Yes	6	7
403	8x48	8x49	lpa1_on	0	0	No	No	No	No	5	7
404	7x31	7x34	lpa1_on	0	0	No	No	No	Yes	3	4
405	1x57	1x58	lpa1_on	0	50	No	No	No	No	7	3
406	1x54	1x58	lpa1_on	0	50	No	No	No	No	7	3
407	7x30	E3.C287	lpa1_on	0	0	No	No	No	No	4	5
408	3x54	5x65	lpa1_on	0	0	No	No	No	No	8	7
409	5x65	5x69	lpa1_on	0	0	No	No	No	No	7	0
410	3x22	E2.I189	lpa1_on	0	0	No	No	No	Yes	2	3
411	5x45	5x49	lpa1_on	0	0	No	No	No	No	4	4
412	7x29	7x32	lpa1_on	0	0	No	No	No	No	1	2
413	2x42	4x45	lpa1_on	0	50	No	No	No	No	8	6
414	6x34	6x38	lpa1_on	0	50	No	No	No	No	7	5
415	NT.L41	NT.T43	lpa1_on	0	0	No	Yes	No	No	2	3
416	NT.A42	NT.H40	lpa1_on	0	0	No	No	No	No	4	2
417	1x48	1x52	lpa1_on	0	0	No	No	No	No	4	7
418	NT.H40	NT.T43	lpa1_on	0	0	No	No	No	No	2	3
419	5x51	5x52	lpa1_on	0	0	No	Yes	No	No	5	3
420	3x30	4x61	lpa1_on	0	0	No	No	No	No	6	6
421	4x47	4x48	lpa1_on	0	0	No	No	No	No	4	3
422	E2.C190	E2.D191	lpa1_on	0	0	No	No	No	No	3	4
423	7x51	7x52	lpa1_on	0	0	No	No	No	No	7	8
424	5x70	6x30	lpa1_on	0	0	No	No	No	Yes	0	7
425	NT.L41	NT.N35	lpa1_on	0	0	No	Yes	No	No	2	7
426	1x31	7x36	lpa1_on	0	0	No	No	No	No	3	4
427	4x40	4x41	lpa1_on	0	0	Yes	No	No	No	5	6
428	8x54	8x55	lpa1_on	0	0	Yes	Yes	No	No	6	4
429	1x58	I1x48	lpa1_on	0	0	No	No	No	No	3	6

Orange: nodes, hubs and links specific of lpa1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of lpa1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	lpa1_off Avg Int. Strength	lpa1_on Avg Int. Strength	lpa1_off Num Of Links	lpa1_on Num Of Links	ConSurf
1	NT.K39	lpa1_off	25	50	4	3	8
2	2x40	lpa1_off	0	50	4	3	9
3	2x45	lpa1_off	75	0	4	3	9
4	3x50	lpa1_off	75	0	5	3	9
5	4x40	lpa1_off	0	0	5	3	5
6	4x49	lpa1_off	0	0	5	3	7
7	E2.M198	lpa1_off	75	100	4	3	3
8	7x42	lpa1_off	25	0	4	2	7
9	7x45	lpa1_off	0	50	4	3	9
10	7x49	lpa1_off	0	0	4	3	9
11	NT.F32	Shared	0	0	5	4	2
12	NT.Y34	Shared	100	100	7	5	6
13	NT.W45	Shared	0	0	4	5	1
14	NT.N46	Shared	0	0	4	4	2
15	1x40	Shared	0	0	4	4	4
16	1x50	Shared	75	50	4	5	9
17	I1x50	Shared	75	50	5	6	8
18	2x38	Shared	25	0	5	4	6
19	2x46	Shared	25	100	4	4	9
20	2x52	Shared	0	0	4	4	7
21	3x25	Shared	100	100	6	6	9
22	3x28	Shared	75	100	5	7	6
23	3x29	Shared	25	100	4	4	4
24	3x33	Shared	25	100	5	4	5
25	3x51	Shared	25	100	4	4	7
26	E2.Y202	Shared	100	100	6	7	4
27	5x39	Shared	100	50	5	4	7
28	5x43	Shared	100	100	6	5	6
29	5x47	Shared	100	100	4	5	7
30	5x58	Shared	100	50	4	4	9
31	6x44	Shared	100	100	4	4	9
32	6x45	Shared	0	0	4	4	6
33	6x48	Shared	100	100	4	7	8
34	7x56	Shared	25	0	4	4	7
35	8x54	Shared	50	0	4	4	6
36	Lig	Shared	100	100	14	14	0
37	NT.F25	lpa1_on	0	0	2	5	7
38	NT.L41	lpa1_on	0	0	2	4	2
39	1x46	lpa1_on	0	100	3	5	8
40	2x50	lpa1_on	25	100	3	5	9
41	2x51	lpa1_on	0	0	3	4	7
42	2x57	lpa1_on	25	100	3	7	7
43	2x60	lpa1_on	0	50	2	4	6
44	3x40	lpa1_on	25	100	2	4	8
45	3x42	lpa1_on	0	50	3	4	8
46	3x43	lpa1_on	0	0	3	4	8
47	3x55	lpa1_on	0	100	2	4	6
48	4x56	lpa1_on	25	50	2	4	5
49	E2.I189	lpa1_on	0	0	3	5	3
50	5x51	lpa1_on	0	0	3	4	5
51	5x62	lpa1_on	0	50	1	4	6
52	6x30	lpa1_on	0	0	2	4	7
53	6x58	lpa1_on	25	100	3	4	4
54	6x59	lpa1_on	0	50	3	4	5
55	7x34	lpa1_on	0	50	3	4	4
56	7x53	lpa1_on	25	100	2	6	9

Orange: nodes, hubs and links specific of lpa1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of lpa1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	lpa1_off Recurrence	lpa1_on Recurrence	lpa1_off Hub1?	lpa1_on Hub1?	lpa1_off Hub2?	lpa1_on Hub2?	ConSurf1	ConSurf2
1	E2.I189	NT.F25	lpa1_off	15.9304	0	No	Yes	No	Yes	3	7
2	NT.F25	NT.Q23	lpa1_off	17.6722	2.66767	No	Yes	No	No	7	3
3	E2.I192	NT.Q23	lpa1_off	19.0579	0	No	No	No	No	1	3
4	E2.I192	NT.R36	lpa1_off	20.7817	2.67238	No	No	No	No	1	3
5	E1x47	E1x48	lpa1_off	11.5191	0.865699	No	No	No	No	5	4
6	E1.T109	E1x47	lpa1_off	12.5307	0	No	No	No	No	5	5
7	E1.T109	Lig	lpa1_off	13.3028	1.05389	No	No	Yes	Yes	5	0
8	2x57	7x38	lpa1_off	17.4987	9.0475	No	Yes	No	No	7	6
9	7x38	Lig	lpa1_off	18.4743	9.70618	No	No	Yes	Yes	6	0
10	6x44	7x45	lpa1_off	71.5868	0	Yes	Yes	Yes	No	9	9
11	6x44	6x48	lpa1_off	100	4.89779	Yes	Yes	Yes	Yes	9	8
12	6x48	Lig	lpa1_off	88.412	0	Yes	Yes	Yes	Yes	8	0
13	8x50	8x54	lpa1_off	15.0985	7.01969	No	No	Yes	Yes	8	6
14	2x40	6x33	lpa1_off	41.5544	0	Yes	No	No	No	9	7
15	2x43	6x33	lpa1_off	66.2447	0	No	No	No	No	8	7
16	2x43	7x53	lpa1_off	66.8133	1.08683	No	No	No	Yes	8	9
17	6x40	7x53	lpa1_off	67.3999	2.90291	No	No	No	Yes	8	9
18	6x40	7x49	lpa1_off	72.8736	0	No	No	Yes	No	8	9
19	2x39	3x50	lpa1_off	18.3546	0	No	No	Yes	No	8	9
20	3x50	6x33	lpa1_off	25.3307	0	Yes	No	No	No	9	7
21	2x38	I2x53	lpa1_off	15.8856	0	Yes	Yes	No	No	6	4
22	3x43	6x44	lpa1_off	27.6441	0	No	Yes	Yes	Yes	8	9
23	5x39	5x43	lpa1_off	12.9706	0	Yes	Yes	Yes	Yes	7	6
24	3x36	6x48	lpa1_off	12.4678	6.83385	No	No	Yes	Yes	7	8
25	3x43	6x41	lpa1_off	21.8531	0	No	Yes	No	No	8	7
26	3x47	5x58	lpa1_off	11.7765	1.56908	No	No	Yes	Yes	8	9
27	5x58	6x41	lpa1_off	14.6944	0	Yes	Yes	No	No	9	7
28	3x47	5x57	lpa1_off	10.756	0	No	No	No	No	8	6
29	4x38	I2x53	lpa1_off	14.3233	0	No	No	No	No	8	4
30	4x38	4x40	lpa1_off	12.7611	1.61378	No	No	Yes	No	8	5
31	E2.I189	E2.N187	lpa1_off	10.6692	5.32358	No	Yes	No	No	3	6
32	E2.M198	Lig	lpa1_off	14.2934	0	Yes	No	Yes	Yes	3	0
33	6x55	Lig	lpa1_off	10.0706	9.54151	No	No	Yes	Yes	6	0
34	5x51	6x44	lpa1_off	14.042	8.58171	No	Yes	Yes	Yes	5	9
35	5x51	6x45	lpa1_off	11.9471	6.76798	No	Yes	Yes	Yes	5	6
36	3x33	Lig	lpa1_off	11.2857	8.98868	Yes	Yes	Yes	Yes	5	0
37	2x46	7x49	lpa1_off	14.3024	0	Yes	Yes	Yes	No	9	9
38	NT.F32	NT.R36	Shared	24.2294	10.6189	Yes	Yes	No	No	2	3
39	NT.F32	NT.F33	Shared	37.0922	29.0833	Yes	Yes	No	No	2	6
40	E2.L201	NT.F33	Shared	38.7562	31.6992	No	No	No	No	1	6
41	3x25	E2.L201	Shared	41.719	54.7602	Yes	Yes	No	No	9	1
42	3x29	Lig	Shared	23.535	19.0995	Yes	Yes	Yes	Yes	4	0
43	3x25	3x29	Shared	19.7193	18.2997	Yes	Yes	Yes	Yes	9	4
44	3x28	Lig	Shared	26.6026	25.4205	Yes	Yes	Yes	Yes	6	0
45	3x25	3x28	Shared	20.9732	22.1177	Yes	Yes	Yes	Yes	9	6
46	1x50	2x50	Shared	16.0172	16.2319	Yes	Yes	No	Yes	9	9
47	2x50	7x49	Shared	20.1832	36.3735	No	Yes	Yes	No	9	9
48	7x45	7x49	Shared	69.7193	72.3023	Yes	No	Yes	No	9	9
49	2x40	I1x50	Shared	16.0322	20.4239	Yes	No	Yes	Yes	9	8
50	2x38	3x49	Shared	33.2196	17.5916	Yes	Yes	No	No	6	8
51	2x39	3x49	Shared	34.9105	24.3054	No	No	No	No	8	8
52	2x39	2x40	Shared	19.429	22.9763	No	No	Yes	No	8	9
53	2x45	3x42	Shared	11.5251	60.5331	Yes	No	No	Yes	9	8
54	2x46	3x42	Shared	18.9501	66.4495	Yes	Yes	No	Yes	9	8
55	2x46	3x43	Shared	21.7603	30.7064	Yes	Yes	No	Yes	9	8
56	5x43	Lig	Shared	14.6974	100	Yes	Yes	Yes	Yes	6	0
57	5x39	E2.W186	Shared	11.2887	10.673	Yes	Yes	No	No	7	6
58	E2.I189	E2.L201	lpa1_on	0	21.2026	No	Yes	No	No	3	1
59	NT.F25	NT.F32	lpa1_on	0	10.6048	No	Yes	Yes	Yes	7	2
60	3x25	E2.Y202	lpa1_on	3.91453	19.4053	Yes	Yes	Yes	Yes	9	4
61	E2.Y202	Lig	lpa1_on	0	29.1397	Yes	Yes	Yes	Yes	4	0
62	7x34	Lig	lpa1_on	0.778117	19.9181	No	Yes	Yes	Yes	4	0
63	7x34	E2.M198	lpa1_on	0.457892	18.2761	No	Yes	Yes	No	4	3
64	6x58	E2.M198	lpa1_on	7.07189	13.2984	No	Yes	Yes	No	4	3
65	1x36	NT.W45	lpa1_on	0	10.099	No	No	Yes	Yes	4	1
66	1x36	2x62	lpa1_on	1.0744	10.9106	No	No	No	No	4	5
67	2x58	2x62	lpa1_on	0	11.6117	No	No	No	No	6	5
68	1x43	2x58	lpa1_on	8.44855	15.5755	No	No	No	No	6	6
69	1x43	2x57	lpa1_on	9.47806	16.3542	No	No	No	Yes	6	7
70	2x57	7x39	lpa1_on	0	16.0178	No	Yes	No	No	7	6
71	1x42	7x39	lpa1_on	0	16.173	No	No	No	No	7	6
72	1x42	1x46	lpa1_on	0	16.2413	No	No	No	Yes	7	8
73	1x46	1x50	lpa1_on	2.24457	12.2798	No	Yes	Yes	Yes	8	9
74	6x48	7x45	lpa1_on	0	72.707	Yes	Yes	Yes	No	8	9
75	5x43	6x48	lpa1_on	0	66.7812	Yes	Yes	Yes	Yes	6	8
76	2x42	3x49	lpa1_on	0	42.0546	No	No	No	No	8	8
77	2x42	4x46	lpa1_on	0	44.6	No	No	No	No	8	8
78	2x45	4x46	lpa1_on	0.882863	45.8538	Yes	No	No	No	9	8
79	2x46	2x50	lpa1_on	0	40.8243	Yes	Yes	No	Yes	9	9
80	3x43	7x49	lpa1_on	0	38.5377	No	Yes	Yes	No	8	9
81	2x45	4x50	lpa1_on	9.81924	15.2909	Yes	No	No	No	9	9
82	3x43	7x53	lpa1_on	0	14.1876	No	Yes	No	Yes	8	9
83	2x52	4x50	lpa1_on	7.68241	12.5526	Yes	Yes	No	No	7	9
84	4x56	5x43	lpa1_on	0	19.4735	No	Yes	Yes	Yes	5	6
85	3x40	5x47	lpa1_on	4.72556	15.1991	No	Yes	Yes	Yes	8	7
86	5x43	5x47	lpa1_on	5.09667	19.3253	Yes	Yes	Yes	Yes	6	7
87	3x40	6x48	lpa1_on	0	37.3874	No	Yes	Yes	Yes	8	8
88	3x40	5x50	lpa1_on	3.5524	53.3699	No	Yes	No	No	8	7
89	5x46	5x50	lpa1_on	0	17.0035	No	No	No	No	5	7
90	4x56	5x46	lpa1_on	1.71485	18.1703	No	Yes	No	No	5	5
91	3x44	5x50	lpa1_on	0	65.4755	No	No	No	No	7	7
92	3x51	5x57	lpa1_on	9.87311	52.6971	Yes	Yes	No	No	7	6
93	5x53	5x57	lpa1_on	0.218471	54.1485	No	No	No	No	5	6
94	3x44	5x53	lpa1_on	1.24499	55.5953	No	No	No	No	7	5
95	3x51	3x55	lpa1_on	1.80463	27.0907	Yes	Yes	No	Yes	7	6
96	3x51	5x61	lpa1_on	5.98552	22.6211	Yes	Yes	No	No	7	9
97	3x54	3x55	lpa1_on	0	21.2449	No	No	No	Yes	8	6
98	3x54	5x61	lpa1_on	1.10433	21.2708	No	No	No	No	8	9
99	5x62	6x33	lpa1_on	0	27.9164	No	Yes	No	No	6	7
100	5x65	6x33	lpa1_on	0	30.6923	No	No	No	No	7	7
101	3x54	5x65	lpa1_on	0	39.4411	No	No	No	No	8	7
102	5x62	6x30	lpa1_on	0	15.5496	No	Yes	No	Yes	6	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
NT.I30	NT.Y34	lpa1_off	5.135	0	0	0	2	1
NT.K39	NT.Y34	Shared	6.5675	9.555	1	1	1	1
NT.L41	NT.Y34	Shared	3.81	5.865	0	0	2	1
E1x50	NT.Y34	Shared	5.615	5.62	0	1	1	1
3x25	NT.Y34	lpa1_off	7.2375	0	1	1	2	1
E2.P200	NT.Y34	Shared	15.645	9.04	1	0	2	1
NT.H40	NT.K39	lpa1_off	4.2575	0	0	0	2	1
7x34	NT.K39	Shared	7.0875	6.075	1	1	1	1
2x57	7x38	Shared	4.1	9.965	0	1	2	1
2x60	3x28	Shared	5.1625	6.68	0	1	2	1
2x60	3x32	Shared	5.3525	4.28	0	1	2	1
2x63	E1x52	lpa1_off	9.27	0	0	0	2	2
E1.T109	Lig	Shared	6.18	6.885	0	0	1	0
3x28	E1x52	Shared	4.86	5.465	1	1	1	2
3x25	3x28	Shared	9	5	1	1	2	1
3x25	3x29	Shared	11.7725	14.785	1	1	2	1
3x25	E2.P200	Shared	4.05	3.375	1	1	2	2
3x25	E2.Y202	Shared	4.1	3.86	1	1	2	1
3x28	3x29	Shared	4.67	4.675	1	1	1	1
3x29	E2.Y202	Shared	8.175	8.455	1	1	1	1
3x29	Lig	Shared	12.0825	12.46	1	1	1	0
3x32	Lig	lpa1_off	3.64	0	0	0	1	0
3x33	E2.Y202	Shared	6.6125	8.05	1	1	1	1
3x33	5x39	Shared	4.6	7.475	1	1	1	2
3x33	5x43	lpa1_off	5.025	0	1	1	1	1
3x33	Lig	Shared	6.3375	5.845	1	1	1	0
3x36	5x43	lpa1_off	3.705	0	1	0	2	1
3x36	5x47	lpa1_off	4.1175	0	1	0	2	2
3x36	6x48	Shared	11.39	6.83	1	0	2	1
3x37	4x56	Shared	7.9025	6.775	0	1	2	2
3x37	5x43	Shared	6.06	6.67	0	1	2	1
3x40	5x47	Shared	4.8	5.91	0	1	2	2
4x60	E2.Y202	Shared	12.8675	11.825	1	1	2	1
4x60	5x39	Shared	20.86	18.775	1	1	2	2
6x54	E2.M198	Shared	6.715	5.65	0	0	2	1
6x58	E2.M198	Shared	7.97	7.62	0	0	2	1
7x34	E2.M198	Shared	8.7975	12.18	1	1	1	1
E2.M198	Lig	lpa1_off	5.9125	0	1	0	1	0
5x39	E2.Y202	Shared	5.705	5.955	1	1	2	1
5x39	5x43	lpa1_off	7.715	0	1	1	2	1
5x40	6x55	Shared	4.4975	6.23	0	0	2	1
5x43	5x47	Shared	5.9325	3.39	1	1	1	2
5x43	Lig	Shared	6.62	9.81	1	1	1	0
6x44	6x48	Shared	16.2875	16.035	0	1	2	1
6x44	7x45	lpa1_off	6.0425	0	0	1	2	2
6x48	7x41	Shared	8.425	3.89	0	1	1	2
6x48	Lig	lpa1_off	4.94	0	0	1	1	0
6x51	Lig	Shared	5.165	2.47	0	0	1	0
6x54	7x31	lpa1_off	4.155	0	0	0	2	2
6x55	Lig	Shared	9.69	4.955	0	0	1	0
6x58	7x31	lpa1_off	4.0725	0	0	0	2	2
7x34	Lig	Shared	16.045	14.58	1	1	1	0
7x35	Lig	Shared	5.565	8.095	0	0	1	0
7x38	Lig	Shared	13.94	14.35	0	0	1	0
Lig	NT.K39	Shared	6.1525	9.6	1	1	0	1
3x28	Lig	Shared	4.0375	5.625	1	1	1	0
1x35	7x35	Shared	3.415	7.59	0	0	2	1
E2.A199	E2.Y202	Shared	3.0025	4	0	0	2	1
3x30	3x33	Shared	2.5175	4.19	0	0	2	1
2x56	3x32	lpa1_off	2.435	0	0	0	2	1
E1.T109	E1x47	lpa1_off	1.82	0	0	0	1	2
7x35	7x36	lpa1_off	1.24	0	0	0	1	2
NT.N35	NT.Y34	lpa1_off	0.29	0	0	0	2	1
Lig	NT.Y34	lpa1_on	0	5.485	1	1	0	1
2x57	2x60	lpa1_on	0	3.52	0	1	2	2
2x63	3x28	lpa1_on	0	4.82	0	0	2	1
3x28	E1x50	lpa1_on	0	3.88	1	1	1	1
E1x50	Lig	lpa1_on	0	3.715	0	1	1	0
3x40	6x44	lpa1_on	0	5.24	0	1	2	2
3x40	6x48	lpa1_on	0	4.29	0	1	2	1
4x56	5x43	lpa1_on	0	5.235	0	1	2	1
E2.Y202	Lig	lpa1_on	0	3.33	1	1	1	0
5x43	6x48	lpa1_on	0	5.625	1	1	1	1
5x47	6x44	lpa1_on	0	6.645	1	1	2	2
5x47	6x48	lpa1_on	0	12.995	1	1	2	1
6x48	7x45	lpa1_on	0	9.04	0	1	1	2
3x25	NT.I30	lpa1_on	0	2.935	1	1	2	2
7x31	7x34	lpa1_on	0	1.99	0	0	2	1
NT.L41	NT.N35	lpa1_on	0	0.685	0	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	lpa1_off	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
	lpa1_on	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2

Network Difference
Value	lpa1_off	lpa1_on
I_min	3.61	3.025
Number of Linked Nodes	287	280
Number of Specific Nodes	13 (4.53%)	6 (2.14%)
Number of Shared Nodes	274 (95.47%)	274 (97.86%)
Number of Links	307	313
Number of Specific Links	116 (37.79%)	122 (38.98%)
Number of Shared Links	191 (62.22%)	191 (61.02%)
Number of Hubs	36	46
Number of Specific Hubs	10 (27.78%)	20 (43.48%)
Number of Shared Hubs	26 (72.22%)	26 (56.52%)
Average % Shared Neighbours (Jaccard)	46.79
Average % Shared Neighbours (Otsuka)	55.93
Average % Shared Neighbours (Overlap Coefficient)	65.47
Average % Shared Cliques (k3-6)	54.84
Graphlets Similarity	0.573094

Paths Difference
Value	lpa1_off	lpa1_on
Number Of Nodes in MetaPath	56	61
Specific Nodes in MetaPath	24 (42.86%)	29 (47.54%)
Shared Nodes in MetaPath	274 (95.47%)	274 (95.47%)
Number Of Links MetaPath	57	65
Specific Links in MetaPath	37 (64.91%)	45 (69.23%)
Shared Links in MetaPath	191 (62.22%)	191 (62.22%)
Number of Shortest Paths	60202	83589
Length Of Smallest Path	3	3
Average Path Length	13.6745	14.5527
Length of Longest Path	32	31
Minimum Path Strength	0.3625	0.595
Average Path Strength	6.61691	6.70226
Maximum Path Strength	16.2275	16.765
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.903705	0.918331
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.57143	4
Average % Of Corr. Nodes	39.982	45.6003
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	42.283	45.4578
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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