psnGPCR

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Orange: nodes, hubs and links specific of lpa1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of lpa1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	lpa1_off Int. Strength	lpa1_on Int. Strength	lpa1_off Hub1?	lpa1_on Hub1?	lpa1_off Hub2?	lpa1_on Hub2?	ConSurf1	ConSurf2
1	3x32	Lig	lpa1_off	100	0	Yes	No	Yes	Yes	6	0
2	E2.M198	Lig	lpa1_off	100	0	Yes	No	Yes	Yes	3	0
3	6x48	Lig	lpa1_off	100	0	Yes	Yes	Yes	Yes	8	0
4	6x51	Lig	lpa1_off	100	0	No	No	Yes	Yes	5	0
5	E2.I192	NT.Q23	lpa1_off	100	0	No	No	No	No	1	3
6	E2.I189	NT.F25	lpa1_off	100	0	No	Yes	No	No	3	7
7	NT.E28	NT.Y26	lpa1_off	100	0	No	No	No	No	4	4
8	3x25	NT.I30	lpa1_off	100	0	Yes	Yes	No	No	9	6
9	3x25	NT.Y34	lpa1_off	100	0	Yes	Yes	Yes	Yes	9	6
10	NT.H40	NT.K39	lpa1_off	100	0	No	No	Yes	No	2	8
11	E1x501	NT.T43	lpa1_off	100	0	No	No	No	No	6	3
12	1x39	7x42	lpa1_off	100	0	No	No	Yes	No	6	7
13	1x42	7x42	lpa1_off	100	0	No	No	Yes	No	7	7
14	1x42	7x43	lpa1_off	100	0	No	No	No	No	7	5
15	1x46	1x50	lpa1_off	100	0	No	No	Yes	Yes	8	9
16	1x46	7x46	lpa1_off	100	0	No	No	No	No	8	9
17	1x52	8x57	lpa1_off	100	0	No	No	No	No	7	6
18	1x53	8x54	lpa1_off	100	0	No	No	Yes	Yes	9	6
19	1x60	8x49	lpa1_off	100	0	No	Yes	No	No	6	7
20	8x47	I1x50	lpa1_off	100	0	No	No	Yes	Yes	8	8
21	8x49	I1x50	lpa1_off	100	0	No	No	Yes	Yes	7	8
22	2x37	I2x52	lpa1_off	100	0	No	No	No	No	7	8
23	2x38	I2x53	lpa1_off	100	0	Yes	No	No	No	6	4
24	2x39	3x50	lpa1_off	100	0	No	No	Yes	No	8	9
25	2x40	6x33	lpa1_off	100	0	No	No	No	No	9	7
26	2x42	3x46	lpa1_off	100	0	No	No	No	No	8	8
27	2x42	4x42	lpa1_off	100	0	No	No	No	No	8	7
28	2x43	6x33	lpa1_off	100	0	No	No	No	No	8	7
29	2x45	4x49	lpa1_off	100	0	Yes	No	Yes	No	9	7
30	2x46	7x49	lpa1_off	100	0	Yes	Yes	No	No	9	9
31	2x59	3x27	lpa1_off	100	0	No	No	No	No	5	4
32	2x60	3x32	lpa1_off	100	0	No	No	Yes	No	6	6
33	2x61	7x42	lpa1_off	100	0	No	No	Yes	No	6	7
34	2x63	E1x52	lpa1_off	100	0	No	No	No	No	5	6
35	E1x48	E1x49	lpa1_off	100	0	No	No	No	No	4	4
36	3x33	5x43	lpa1_off	100	0	Yes	Yes	Yes	Yes	5	6
37	3x36	5x47	lpa1_off	100	0	No	No	Yes	Yes	7	7
38	3x43	6x41	lpa1_off	100	0	No	Yes	No	No	8	7
39	3x43	6x44	lpa1_off	100	0	No	Yes	Yes	Yes	8	9
40	3x44	5x54	lpa1_off	100	0	No	No	No	No	7	9
41	3x46	6x37	lpa1_off	100	0	No	No	No	No	8	8
42	3x49	I2x53	lpa1_off	100	0	No	Yes	No	No	8	4
43	3x50	3x53	lpa1_off	100	0	Yes	No	No	No	9	8
44	3x50	6x30	lpa1_off	100	0	Yes	No	No	Yes	9	7
45	3x50	6x33	lpa1_off	100	0	Yes	No	No	No	9	7
46	3x50	6x34	lpa1_off	100	0	Yes	No	No	No	9	7
47	6x26	I2x51	lpa1_off	100	0	No	No	No	No	4	4
48	4x38	I2x53	lpa1_off	100	0	No	No	No	No	8	4
49	4x56	5x46	lpa1_off	100	0	No	No	No	No	5	5
50	5x36	E2.W186	lpa1_off	100	0	No	No	Yes	No	5	6
51	5x42	E2.W186	lpa1_off	100	0	No	No	Yes	No	6	6
52	E2.D191	E2.N194	lpa1_off	100	0	No	No	No	No	4	3
53	5x40	E2.S196	lpa1_off	100	0	No	No	No	No	6	5
54	5x39	5x43	lpa1_off	100	0	Yes	Yes	Yes	Yes	7	6
55	5x43	5x47	lpa1_off	100	0	Yes	Yes	Yes	Yes	6	7
56	5x48	6x49	lpa1_off	100	0	No	No	No	No	5	5
57	5x54	6x41	lpa1_off	100	0	No	No	No	No	9	7
58	5x58	6x38	lpa1_off	100	0	Yes	Yes	No	No	9	5
59	5x58	6x41	lpa1_off	100	0	Yes	Yes	No	No	9	7
60	6x39	7x56	lpa1_off	100	0	No	No	Yes	No	6	7
61	6x40	7x49	lpa1_off	100	0	No	No	No	No	8	9
62	6x40	7x52	lpa1_off	100	0	No	No	No	No	8	8
63	6x44	7x45	lpa1_off	100	0	Yes	Yes	No	No	9	9
64	6x47	6x48	lpa1_off	100	0	No	No	Yes	Yes	9	8
65	6x54	7x31	lpa1_off	100	0	No	No	No	No	4	3
66	6x57	6x61	lpa1_off	100	0	No	No	No	No	5	4
67	6x58	7x31	lpa1_off	100	0	No	Yes	No	No	4	3
68	7x29	7x33	lpa1_off	100	0	No	No	No	No	1	3
69	7x45	7x48	lpa1_off	100	0	No	No	No	No	9	6
70	8x47	8x50	lpa1_off	100	0	No	No	No	Yes	8	8
71	6x35	7x56	lpa1_off	100	0	No	No	Yes	No	7	7
72	I2x54	I2x55	lpa1_off	100	0	No	No	No	No	4	3
73	1x57	I1x50	lpa1_off	33.3333	0	No	No	Yes	Yes	7	8
74	6x27	6x31	lpa1_off	33.3333	0	No	No	No	No	4	5
75	1x45	1x49	lpa1_off	66.6667	0	No	No	No	No	4	8
76	2x57	3x32	lpa1_off	66.6667	0	No	Yes	Yes	No	7	6
77	4x59	5x39	lpa1_off	33.3333	0	No	No	Yes	Yes	5	7
78	6x30	I2x51	lpa1_off	33.3333	0	No	Yes	No	No	7	4
79	4x40	I2x55	lpa1_off	33.3333	0	No	No	No	No	5	3
80	I2x54	I2x56	lpa1_off	33.3333	0	No	No	No	No	4	6
81	2x49	3x39	lpa1_off	0	0	No	No	No	No	8	9
82	1x56	8x53	lpa1_off	0	0	No	No	No	No	7	7
83	3x52	3x56	lpa1_off	33.3333	0	No	No	No	No	5	5
84	5x62	6x35	lpa1_off	66.6667	0	No	Yes	No	No	6	7
85	4x39	I2x55	lpa1_off	33.3333	0	No	No	No	No	3	3
86	6x47	7x40	lpa1_off	0	0	No	No	No	No	9	7
87	3x47	5x57	lpa1_off	0	0	No	No	No	No	8	6
88	1x55	8x57	lpa1_off	33.3333	0	No	No	No	No	5	6
89	4x45	4x49	lpa1_off	0	0	No	No	Yes	No	6	7
90	2x46	3x39	lpa1_off	0	0	Yes	Yes	No	No	9	9
91	3x22	E2.L201	lpa1_off	0	0	No	No	No	No	2	1
92	3x21	NT.N27	lpa1_off	33.3333	0	No	No	No	No	6	8
93	1x36	1x40	lpa1_off	0	0	Yes	No	No	Yes	4	4
94	3x26	E2.N187	lpa1_off	0	0	No	No	No	No	5	6
95	2x38	4x39	lpa1_off	33.3333	0	Yes	No	No	No	6	3
96	3x41	4x52	lpa1_off	33.3333	0	No	No	No	No	5	4
97	2x53	2x57	lpa1_off	0	0	No	No	No	Yes	8	7
98	7x39	7x42	lpa1_off	0	0	No	No	Yes	No	6	7
99	NT.F32	NT.S29	lpa1_off	33.3333	0	Yes	No	No	No	2	4
100	7x54	8x54	lpa1_off	66.6667	0	No	No	Yes	Yes	7	6
101	E2.I192	NT.F32	lpa1_off	0	0	No	No	Yes	No	1	2
102	1x44	2x58	lpa1_off	0	0	No	No	No	No	4	6
103	1x54	2x51	lpa1_off	0	0	No	No	No	No	7	7
104	1x36	NT.W45	lpa1_off	0	0	Yes	No	Yes	No	4	1
105	I1x48	I1x51	lpa1_off	33.3333	0	No	No	No	No	6	8
106	E3.P285	E3.Q286	lpa1_off	33.3333	0	No	No	No	No	3	4
107	1x58	1x59	lpa1_off	0	0	No	No	No	No	3	5
108	1x32	NT.W45	lpa1_off	0	0	No	No	Yes	No	1	1
109	6x32	6x35	lpa1_off	33.3333	0	No	No	No	No	7	7
110	1x44	1x48	lpa1_off	0	0	No	No	No	No	4	4
111	E3.C287	E3.P285	lpa1_off	0	0	No	No	No	No	5	3
112	NT.C24	NT.F25	lpa1_off	0	0	No	No	No	No	5	7
113	8x56	8x57	lpa1_off	33.3333	0	No	No	No	No	4	6
114	1x35	Lig	lpa1_off	33.3333	0	No	No	Yes	Yes	5	0
115	E1x47	E1x50	lpa1_off	0	0	No	No	No	No	5	5
116	5x37	E2.N194	lpa1_off	33.3333	0	No	No	No	No	4	3
117	3x38	4x53	lpa1_off	0	0	No	No	No	No	7	8
118	1x47	2x54	lpa1_off	0	0	No	No	No	No	6	7
119	E2.C195	NT.S37	lpa1_off	0	0	No	No	No	No	9	7
120	4x58	4x62	lpa1_off	0	0	No	No	No	No	4	5
121	4x63	E2.N187	lpa1_off	0	0	No	No	No	No	5	6
122	7x35	7x36	lpa1_off	0	0	No	No	No	No	4	4
123	4x47	4x51	lpa1_off	0	0	No	No	No	No	4	3
124	6x49	6x53	lpa1_off	0	0	No	No	No	No	5	6
125	NT.A31	NT.L41	lpa1_off	0	0	No	No	No	No	2	2
126	5x44	6x55	lpa1_off	0	0	No	No	No	No	4	6
127	5x55	6x45	lpa1_off	0	0	No	No	Yes	No	4	6
128	5x61	5x65	lpa1_off	0	0	No	No	No	No	9	7
129	5x65	6x31	lpa1_off	0	0	No	No	No	No	7	5
130	3x48	3x52	lpa1_off	0	0	No	No	No	No	6	5
131	I2x50	I2x51	lpa1_off	33.3333	0	No	No	No	No	7	4
132	1x36	1x37	lpa1_off	0	0	Yes	No	No	No	4	4
133	5x41	6x60	lpa1_off	0	0	No	No	No	No	4	4
134	5x49	5x50	lpa1_off	0	0	No	No	No	No	4	7
135	NT.E21	NT.P22	lpa1_off	0	0	No	No	No	No	0	0
136	NT.A42	NT.E44	lpa1_off	0	0	No	No	No	No	4	1
137	6x45	6x46	lpa1_off	0	0	Yes	No	No	No	6	5
138	4x40	4x44	lpa1_off	0	0	No	No	No	No	5	3
139	8x58	8x59	lpa1_off	0	0	No	No	No	No	6	4
140	6x32	8x48	lpa1_off	0	0	No	No	No	No	7	5
141	NT.F32	NT.P22	lpa1_off	0	0	Yes	No	No	No	2	0
142	8x52	8x55	lpa1_off	0	0	No	No	No	No	4	4
143	6x25	6x26	lpa1_off	0	0	No	No	No	No	4	4
144	E1.T109	Lig	Shared	100	100	No	No	Yes	Yes	5	0
145	3x29	Lig	Shared	100	100	No	Yes	Yes	Yes	4	0
146	3x33	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
147	5x43	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
148	6x55	Lig	Shared	100	100	No	No	Yes	Yes	6	0
149	7x34	Lig	Shared	100	100	No	No	Yes	Yes	4	0
150	7x35	Lig	Shared	100	100	No	No	Yes	Yes	4	0
151	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
152	E2.C190	NT.C24	Shared	100	100	No	No	No	No	3	5
153	NT.E28	NT.F32	Shared	100	100	No	No	Yes	No	4	2
154	NT.I30	NT.Y34	Shared	100	50	No	No	Yes	Yes	6	6
155	NT.F32	NT.F33	Shared	100	100	Yes	No	No	No	2	6
156	E2.L201	NT.F33	Shared	100	100	No	No	No	No	1	6
157	NT.K39	NT.Y34	Shared	100	100	Yes	No	Yes	Yes	8	6
158	NT.L41	NT.Y34	Shared	100	100	No	No	Yes	Yes	2	6
159	E1x50	NT.Y34	Shared	100	100	No	No	Yes	Yes	5	6
160	E2.P200	NT.Y34	Shared	100	100	No	No	Yes	Yes	6	6
161	E2.I192	NT.R36	Shared	100	100	No	No	No	No	1	3
162	7x34	NT.K39	Shared	100	100	No	No	Yes	No	4	8
163	E1x501	NT.L41	Shared	100	50	No	No	No	No	6	2
164	1x33	NT.W45	Shared	100	0	No	No	Yes	No	3	1
165	E1x48	NT.W45	Shared	100	100	No	No	Yes	No	4	1
166	E1x49	NT.W45	Shared	100	50	No	No	Yes	No	4	1
167	1x31	NT.N46	Shared	100	100	No	No	No	Yes	3	2
168	1x39	2x61	Shared	100	50	No	No	No	No	6	6
169	1x40	2x58	Shared	100	100	No	Yes	No	No	4	6
170	1x43	2x58	Shared	100	100	No	No	No	No	6	6
171	1x47	2x51	Shared	100	100	No	No	No	No	6	7
172	1x47	2x55	Shared	100	100	No	No	No	No	6	4
173	1x50	2x47	Shared	100	100	Yes	Yes	No	No	9	9
174	1x50	2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
175	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
176	1x51	2x51	Shared	100	0	No	No	No	No	4	7
177	1x60	I1x50	Shared	100	100	No	Yes	Yes	Yes	6	8
178	1x60	8x53	Shared	100	100	No	Yes	No	No	6	7
179	8x49	I1x49	Shared	100	100	No	No	No	No	7	6
180	2x40	I1x50	Shared	100	100	No	No	Yes	Yes	9	8
181	8x50	I1x50	Shared	100	100	No	Yes	Yes	Yes	8	8
182	2x41	I1x51	Shared	100	100	No	No	No	No	4	8
183	2x37	2x38	Shared	100	100	No	No	Yes	No	7	6
184	2x38	3x49	Shared	100	100	Yes	No	No	Yes	6	8
185	2x39	2x40	Shared	100	100	No	No	No	No	8	9
186	2x39	3x49	Shared	100	100	No	No	No	Yes	8	8
187	2x41	4x39	Shared	100	100	No	No	No	No	4	3
188	2x43	7x53	Shared	100	100	No	No	No	Yes	8	9
189	2x45	3x42	Shared	100	100	Yes	No	No	Yes	9	8
190	2x45	4x46	Shared	100	100	Yes	No	No	No	9	8
191	2x45	4x50	Shared	100	100	Yes	No	No	No	9	9
192	2x46	3x42	Shared	100	100	Yes	Yes	No	Yes	9	8
193	2x46	3x43	Shared	100	100	Yes	Yes	No	Yes	9	8
194	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
195	2x50	7x49	Shared	100	100	No	Yes	No	No	9	9
196	2x52	3x34	Shared	100	100	No	Yes	No	Yes	7	6
197	2x52	4x50	Shared	100	50	No	Yes	No	No	7	9
198	2x57	7x42	Shared	100	100	No	Yes	Yes	No	7	7
199	2x59	2x63	Shared	100	100	No	No	No	No	5	5
200	2x60	3x28	Shared	100	100	No	No	No	Yes	6	6
201	E1x47	E1x48	Shared	100	100	No	No	No	No	5	4
202	3x24	E1x52	Shared	100	100	No	No	No	No	4	6
203	3x28	E1x52	Shared	100	100	No	Yes	No	No	6	6
204	3x21	3x23	Shared	100	50	No	No	No	No	6	1
205	3x21	3x24	Shared	100	100	No	No	No	No	6	4
206	3x25	3x28	Shared	100	100	Yes	Yes	No	Yes	9	6
207	3x25	3x29	Shared	100	100	Yes	Yes	No	Yes	9	4
208	3x25	E2.L201	Shared	100	100	Yes	Yes	No	No	9	1
209	3x25	E2.Y202	Shared	100	100	Yes	Yes	Yes	Yes	9	4
210	3x29	E2.Y202	Shared	100	100	No	Yes	Yes	Yes	4	4
211	3x33	E2.Y202	Shared	100	100	Yes	Yes	Yes	Yes	5	4
212	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	8
213	3x37	4x56	Shared	100	100	No	No	No	No	6	5
214	3x37	5x43	Shared	100	100	No	No	Yes	Yes	6	6
215	3x38	4x50	Shared	100	100	No	No	No	No	7	9
216	3x40	5x47	Shared	100	100	No	No	Yes	Yes	8	7
217	3x41	4x49	Shared	100	100	No	No	Yes	No	5	7
218	3x42	4x49	Shared	100	100	No	Yes	Yes	No	8	7
219	3x47	5x58	Shared	100	100	No	No	Yes	Yes	8	9
220	3x51	3x55	Shared	100	100	Yes	Yes	No	Yes	7	6
221	3x51	5x57	Shared	100	100	Yes	Yes	No	No	7	6
222	3x51	5x60	Shared	100	100	Yes	Yes	No	No	7	5
223	3x51	5x61	Shared	100	100	Yes	Yes	No	No	7	9
224	3x54	5x61	Shared	100	100	No	No	No	No	8	9
225	3x55	5x60	Shared	100	100	No	Yes	No	No	6	5
226	3x55	5x64	Shared	100	100	No	Yes	No	No	6	6
227	4x41	I2x56	Shared	100	100	No	No	No	No	6	6
228	4x60	E2.Y202	Shared	100	100	No	No	Yes	Yes	6	4
229	4x60	5x39	Shared	100	100	No	No	Yes	Yes	6	7
230	5x38	E2.W186	Shared	100	100	No	No	Yes	No	5	6
231	5x39	E2.W186	Shared	100	100	Yes	Yes	Yes	No	7	6
232	E2.I189	E2.N187	Shared	100	100	No	Yes	No	No	3	6
233	E2.C188	E2.C195	Shared	100	100	No	No	No	No	5	9
234	6x58	E2.N197	Shared	100	100	No	Yes	No	No	4	5
235	6x54	E2.M198	Shared	100	100	No	No	Yes	No	4	3
236	6x58	E2.M198	Shared	100	100	No	Yes	Yes	No	4	3
237	7x34	E2.M198	Shared	100	100	No	No	Yes	No	4	3
238	5x39	E2.Y202	Shared	100	100	Yes	Yes	Yes	Yes	7	4
239	5x36	5x38	Shared	100	100	No	No	No	No	5	5
240	5x37	6x59	Shared	100	100	No	No	No	No	4	5
241	5x40	6x55	Shared	100	100	No	No	No	No	6	6
242	5x44	6x56	Shared	100	0	No	No	No	No	4	6
243	5x47	6x52	Shared	100	100	Yes	Yes	No	No	7	6
244	5x51	6x44	Shared	100	100	No	No	Yes	Yes	5	9
245	5x51	6x45	Shared	100	100	No	No	Yes	No	5	6
246	6x36	7x56	Shared	100	100	No	No	Yes	No	8	7
247	6x39	7x52	Shared	100	0	No	No	No	No	6	8
248	6x40	7x53	Shared	100	100	No	No	No	Yes	8	9
249	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
250	6x47	7x45	Shared	100	100	No	No	No	No	9	9
251	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
252	6x50	7x37	Shared	100	100	No	No	Yes	Yes	9	5
253	6x51	7x37	Shared	100	50	No	No	Yes	Yes	5	5
254	6x54	7x37	Shared	100	100	No	No	Yes	Yes	4	5
255	6x61	E3.C287	Shared	100	100	No	No	No	No	4	5
256	7x33	7x37	Shared	100	100	No	No	Yes	Yes	3	5
257	7x55	7x56	Shared	100	100	No	No	Yes	No	5	7
258	8x50	8x54	Shared	100	100	No	Yes	Yes	Yes	8	6
259	Lig	NT.K39	Shared	100	100	Yes	Yes	Yes	No	0	8
260	5x58	6x37	Shared	33.3333	100	Yes	Yes	No	No	9	8
261	1x45	7x51	Shared	66.6667	0	No	No	No	No	4	7
262	1x49	7x50	Shared	33.3333	50	No	No	No	No	8	9
263	3x40	5x50	Shared	33.3333	100	No	No	No	No	8	7
264	1x52	8x54	Shared	66.6667	100	No	No	Yes	Yes	7	6
265	3x34	4x57	Shared	33.3333	0	No	Yes	No	No	6	7
266	3x26	4x61	Shared	33.3333	0	No	No	No	No	5	6
267	1x32	NT.N46	Shared	33.3333	100	No	No	No	Yes	1	2
268	2x53	3x35	Shared	0	100	No	No	No	No	8	6
269	1x36	2x62	Shared	0	100	Yes	No	No	No	4	5
270	4x55	4x59	Shared	0	100	No	No	No	No	4	5
271	6x45	6x49	Shared	0	100	Yes	No	No	No	6	5
272	6x53	6x57	Shared	0	0	No	No	No	No	6	5
273	1x45	7x47	Shared	0	0	No	No	No	No	4	7
274	5x41	6x59	Shared	0	100	No	No	No	No	4	5
275	E2.A199	E2.Y202	Shared	0	100	No	No	Yes	Yes	4	4
276	5x37	E2.S196	Shared	0	0	No	No	No	No	4	5
277	2x52	3x31	Shared	0	0	No	Yes	No	No	7	5
278	1x46	2x54	Shared	0	100	No	No	No	No	8	7
279	3x26	E2.Y202	Shared	0	50	No	No	Yes	Yes	5	4
280	E2.E193	NT.R36	Shared	33.3333	100	No	No	No	No	4	3
281	2x56	3x32	Shared	0	100	No	No	Yes	No	5	6
282	3x45	4x49	Shared	0	50	No	No	Yes	No	8	7
283	1x54	2x48	Shared	0	0	No	No	No	No	7	6
284	6x43	7x48	Shared	0	0	No	No	No	No	6	6
285	NT.G38	NT.S37	Shared	0	100	No	No	No	No	4	7
286	E1.T109	E1x47	Shared	0	100	No	No	No	No	5	5
287	5x36	E2.C188	Shared	0	0	No	No	No	No	5	5
288	3x30	3x33	Shared	0	100	No	No	Yes	Yes	6	5
289	1x57	2x44	Shared	0	100	No	No	No	No	7	7
290	1x55	1x59	Shared	0	0	No	No	No	No	5	5
291	5x44	6x52	Shared	0	50	No	No	No	No	4	6
292	1x30	NT.N46	Shared	0	50	No	No	No	Yes	5	2
293	3x44	3x48	Shared	0	100	No	No	No	No	7	6
294	1x38	7x39	Shared	0	100	No	No	No	No	4	6
295	4x40	4x43	Shared	33.3333	50	No	No	No	No	5	1
296	6x59	6x60	Shared	0	50	No	No	No	No	5	4
297	NT.E44	NT.T43	Shared	0	0	No	No	No	No	1	3
298	6x28	6x31	Shared	0	0	No	No	No	No	5	5
299	4x48	4x52	Shared	0	0	No	No	No	No	3	4
300	NT.E28	NT.F25	lpa1_on	0	100	No	No	No	No	4	7
301	E2.I189	NT.Y26	lpa1_on	0	100	No	Yes	No	No	3	4
302	NT.F32	NT.R36	lpa1_on	0	100	Yes	No	No	No	2	3
303	Lig	NT.Y34	lpa1_on	0	100	Yes	Yes	Yes	Yes	0	6
304	1x35	7x35	lpa1_on	0	100	No	No	No	No	5	4
305	1x40	2x62	lpa1_on	0	100	No	Yes	No	No	4	5
306	1x42	1x46	lpa1_on	0	100	No	No	No	No	7	8
307	1x43	2x57	lpa1_on	0	100	No	No	No	Yes	6	7
308	1x46	7x47	lpa1_on	0	100	No	No	No	No	8	7
309	1x53	1x57	lpa1_on	0	100	No	No	No	No	9	7
310	1x53	2x47	lpa1_on	0	100	No	No	No	No	9	9
311	I1x49	I1x50	lpa1_on	0	100	No	No	Yes	Yes	6	8
312	8x53	I1x50	lpa1_on	0	100	No	No	Yes	Yes	7	8
313	2x38	4x42	lpa1_on	0	100	Yes	No	No	No	6	7
314	2x40	8x47	lpa1_on	0	100	No	No	No	No	9	8
315	2x41	4x42	lpa1_on	0	100	No	No	No	No	4	7
316	2x42	3x49	lpa1_on	0	100	No	No	No	Yes	8	8
317	2x46	2x50	lpa1_on	0	100	Yes	Yes	No	Yes	9	9
318	2x46	3x46	lpa1_on	0	100	Yes	Yes	No	No	9	8
319	2x50	3x39	lpa1_on	0	100	No	Yes	No	No	9	9
320	2x56	3x31	lpa1_on	0	100	No	No	No	No	5	5
321	2x57	2x61	lpa1_on	0	100	No	Yes	No	No	7	6
322	2x57	7x38	lpa1_on	0	100	No	Yes	No	No	7	6
323	2x57	7x39	lpa1_on	0	100	No	Yes	No	No	7	6
324	2x58	2x62	lpa1_on	0	100	No	No	No	No	6	5
325	2x63	3x28	lpa1_on	0	100	No	No	No	Yes	5	6
326	7x35	E1.T109	lpa1_on	0	100	No	No	No	No	4	5
327	E1x49	E1x51	lpa1_on	0	100	No	No	No	No	4	3
328	3x28	E1x50	lpa1_on	0	100	No	Yes	No	No	6	5
329	E1x50	Lig	lpa1_on	0	100	No	No	Yes	Yes	5	0
330	3x25	E2.P200	lpa1_on	0	100	Yes	Yes	No	No	9	6
331	3x27	3x31	lpa1_on	0	100	No	No	No	No	4	5
332	3x28	Lig	lpa1_on	0	100	No	Yes	Yes	Yes	6	0
333	3x33	5x39	lpa1_on	0	100	Yes	Yes	Yes	Yes	5	7
334	3x36	7x42	lpa1_on	0	100	No	No	Yes	No	7	7
335	3x40	6x44	lpa1_on	0	100	No	No	Yes	Yes	8	9
336	3x43	7x49	lpa1_on	0	100	No	Yes	No	No	8	9
337	3x43	7x53	lpa1_on	0	100	No	Yes	No	Yes	8	9
338	3x44	5x50	lpa1_on	0	100	No	No	No	No	7	7
339	3x46	3x50	lpa1_on	0	100	No	No	Yes	No	8	9
340	3x46	7x53	lpa1_on	0	100	No	No	No	Yes	8	9
341	3x50	5x58	lpa1_on	0	100	Yes	No	Yes	Yes	9	9
342	3x50	7x53	lpa1_on	0	100	Yes	No	No	Yes	9	9
343	3x52	4x41	lpa1_on	0	100	No	No	No	No	5	6
344	3x53	3x56	lpa1_on	0	100	No	No	No	No	8	5
345	3x54	3x55	lpa1_on	0	100	No	No	No	Yes	8	6
346	3x56	I2x54	lpa1_on	0	100	No	No	No	No	5	4
347	3x56	I2x56	lpa1_on	0	100	No	No	No	No	5	6
348	5x68	I2x50	lpa1_on	0	100	No	No	No	No	0	7
349	I2x51	I2x54	lpa1_on	0	100	No	No	No	No	4	4
350	I2x52	I2x53	lpa1_on	0	100	No	No	No	No	8	4
351	I2x53	I2x55	lpa1_on	0	100	No	No	No	No	4	3
352	4x38	4x40	lpa1_on	0	100	No	No	No	No	8	5
353	4x56	5x42	lpa1_on	0	100	No	No	No	No	5	6
354	4x56	5x43	lpa1_on	0	100	No	No	Yes	Yes	5	6
355	4x59	4x60	lpa1_on	0	100	No	No	No	No	5	6
356	4x59	E2.W186	lpa1_on	0	100	No	No	Yes	No	5	6
357	E2.I189	E2.L201	lpa1_on	0	100	No	Yes	No	No	3	1
358	6x58	E2.S196	lpa1_on	0	100	No	Yes	No	No	4	5
359	5x40	Lig	lpa1_on	0	100	No	No	Yes	Yes	6	0
360	5x41	5x45	lpa1_on	0	100	No	No	No	No	4	4
361	5x43	6x48	lpa1_on	0	100	Yes	Yes	Yes	Yes	6	8
362	5x46	5x50	lpa1_on	0	100	No	No	No	No	5	7
363	5x47	6x44	lpa1_on	0	100	Yes	Yes	Yes	Yes	7	9
364	5x47	6x48	lpa1_on	0	100	Yes	Yes	Yes	Yes	7	8
365	5x51	5x55	lpa1_on	0	100	No	No	No	No	5	4
366	5x55	6x41	lpa1_on	0	100	No	No	No	No	4	7
367	5x58	6x40	lpa1_on	0	100	Yes	Yes	No	No	9	8
368	5x62	6x33	lpa1_on	0	100	No	Yes	No	No	6	7
369	5x62	6x34	lpa1_on	0	100	No	Yes	No	No	6	7
370	5x64	5x68	lpa1_on	0	100	No	No	No	No	6	0
371	5x65	6x33	lpa1_on	0	100	No	No	No	No	7	7
372	5x66	6x30	lpa1_on	0	100	No	No	No	Yes	0	7
373	6x28	6x30	lpa1_on	0	100	No	No	No	Yes	5	7
374	6x31	6x35	lpa1_on	0	100	No	No	No	No	5	7
375	6x32	7x56	lpa1_on	0	100	No	No	Yes	No	7	7
376	6x39	7x55	lpa1_on	0	100	No	No	No	No	6	5
377	6x42	6x45	lpa1_on	0	100	No	No	Yes	No	4	6
378	6x48	7x45	lpa1_on	0	100	Yes	Yes	No	No	8	9
379	6x49	6x50	lpa1_on	0	100	No	No	No	No	5	9
380	6x58	7x30	lpa1_on	0	100	No	Yes	No	Yes	4	4
381	7x32	7x33	lpa1_on	0	100	No	No	No	No	2	3
382	7x45	7x49	lpa1_on	0	100	No	No	No	No	9	9
383	7x52	7x53	lpa1_on	0	100	No	No	No	Yes	8	9
384	7x54	8x50	lpa1_on	0	100	No	No	No	Yes	7	8
385	NT.F25	NT.Q23	lpa1_on	0	100	No	No	No	No	7	3
386	3x28	3x29	lpa1_on	0	100	No	Yes	No	Yes	6	4
387	7x43	7x48	lpa1_on	0	100	No	No	No	No	5	6
388	3x34	4x54	lpa1_on	0	50	No	Yes	No	No	6	3
389	1x50	2x51	lpa1_on	0	50	Yes	Yes	No	No	9	7
390	E2.N197	NT.S37	lpa1_on	0	50	No	No	No	No	5	7
391	1x42	7x39	lpa1_on	0	50	No	No	No	No	7	6
392	3x44	5x53	lpa1_on	0	0	No	No	No	No	7	5
393	5x53	5x57	lpa1_on	0	0	No	No	No	No	5	6
394	6x34	6x38	lpa1_on	0	0	No	No	No	No	7	5
395	6x57	7x30	lpa1_on	0	50	No	No	No	Yes	5	4
396	1x57	8x50	lpa1_on	0	50	No	No	No	Yes	7	8
397	3x49	4x41	lpa1_on	0	50	No	Yes	No	No	8	6
398	3x43	5x54	lpa1_on	0	0	No	Yes	No	No	8	9
399	6x61	E3.P285	lpa1_on	0	50	No	No	No	No	4	3
400	1x56	8x54	lpa1_on	0	50	No	No	Yes	Yes	7	6
401	7x43	7x47	lpa1_on	0	0	No	No	No	No	5	7
402	1x34	1x38	lpa1_on	0	50	No	No	No	No	4	4
403	5x62	5x66	lpa1_on	0	50	No	Yes	No	No	6	0
404	2x52	3x35	lpa1_on	0	0	No	Yes	No	No	7	6
405	3x34	4x53	lpa1_on	0	50	No	Yes	No	No	6	8
406	3x37	4x53	lpa1_on	0	50	No	No	No	No	6	8
407	6x50	7x40	lpa1_on	0	50	No	No	No	No	9	7
408	2x49	3x42	lpa1_on	0	50	No	No	No	Yes	8	8
409	7x29	7x32	lpa1_on	0	50	No	No	No	No	1	2
410	5x62	5x63	lpa1_on	0	0	No	Yes	No	No	6	2
411	2x42	4x45	lpa1_on	0	0	No	No	No	No	8	6
412	3x22	3x26	lpa1_on	0	0	No	No	No	No	2	5
413	1x40	1x44	lpa1_on	0	0	No	Yes	No	No	4	4
414	5x48	6x52	lpa1_on	0	50	No	No	No	No	5	6
415	8x48	8x49	lpa1_on	0	0	No	No	No	No	5	7
416	E2.E193	E2.N194	lpa1_on	0	0	No	No	No	No	4	3
417	NT.E44	NT.N46	lpa1_on	0	50	No	No	No	Yes	1	2
418	4x62	4x63	lpa1_on	0	50	No	No	No	No	5	5
419	1x37	1x40	lpa1_on	0	0	No	No	No	Yes	4	4
420	NT.A31	NT.S29	lpa1_on	0	0	No	No	No	No	2	4
421	7x30	E3.C287	lpa1_on	0	0	No	Yes	No	No	4	5
422	6x46	6x47	lpa1_on	0	0	No	No	No	No	5	9
423	E2.C190	E2.I189	lpa1_on	0	50	No	No	No	Yes	3	3
424	3x54	5x65	lpa1_on	0	0	No	No	No	No	8	7
425	4x42	4x43	lpa1_on	0	0	No	No	No	No	7	1
426	5x65	5x69	lpa1_on	0	0	No	No	No	No	7	0
427	5x45	5x49	lpa1_on	0	0	No	No	No	No	4	4
428	8x48	8x51	lpa1_on	0	0	No	No	No	No	5	8
429	6x29	6x30	lpa1_on	0	0	No	No	No	Yes	5	7
430	7x30	7x31	lpa1_on	0	0	No	Yes	No	No	4	3
431	1x59	1x60	lpa1_on	0	0	No	No	No	Yes	5	6
432	NT.L41	NT.T43	lpa1_on	0	0	No	No	No	No	2	3
433	NT.A42	NT.H40	lpa1_on	0	0	No	No	No	No	4	2
434	1x48	1x52	lpa1_on	0	0	No	No	No	No	4	7
435	4x52	5x46	lpa1_on	0	0	No	No	No	No	4	5
436	1x60	I1x48	lpa1_on	0	0	No	Yes	No	No	6	6
437	NT.N27	NT.Y26	lpa1_on	0	0	No	No	No	No	8	4
438	5x36	E2.C195	lpa1_on	0	0	No	No	No	No	5	9
439	4x61	4x62	lpa1_on	0	0	No	No	No	No	6	5
440	1x54	2x47	lpa1_on	0	0	No	No	No	No	7	9
441	4x43	4x47	lpa1_on	0	0	No	No	No	No	1	4
442	4x44	4x48	lpa1_on	0	0	No	No	No	No	3	3
443	4x47	4x48	lpa1_on	0	0	No	No	No	No	4	3
444	5x52	5x56	lpa1_on	0	0	No	No	No	No	3	4
445	5x49	5x52	lpa1_on	0	0	No	No	No	No	4	3
446	1x41	1x42	lpa1_on	0	0	No	No	No	No	5	7
447	4x51	4x55	lpa1_on	0	0	No	No	No	No	3	4
448	NT.A31	NT.N35	lpa1_on	0	0	No	No	No	No	2	7
449	E2.C190	E2.D191	lpa1_on	0	0	No	No	No	No	3	4
450	NT.A42	NT.N46	lpa1_on	0	0	No	No	No	Yes	4	2
451	5x70	5x73	lpa1_on	0	0	No	No	No	No	0	0
452	5x70	6x30	lpa1_on	0	0	No	No	No	Yes	0	7
453	5x73	I3.R241	lpa1_on	0	0	No	No	No	No	0	0
454	1x35	7x36	lpa1_on	0	0	No	No	No	No	5	4
455	1x31	7x36	lpa1_on	0	0	No	No	No	No	3	4
456	NT.N35	NT.Y34	lpa1_on	0	0	No	No	Yes	Yes	7	6
457	8x54	8x55	lpa1_on	0	0	Yes	Yes	No	No	6	4

Orange: nodes, hubs and links specific of lpa1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of lpa1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	lpa1_off Avg Int. Strength	lpa1_on Avg Int. Strength	lpa1_off Num Of Links	lpa1_on Num Of Links	ConSurf
1	NT.F32	lpa1_off	0	0	5	3	2
2	NT.K39	lpa1_off	33.3333	0	4	3	8
3	NT.W45	lpa1_off	0	0	5	3	1
4	1x36	lpa1_off	0	0	4	1	4
5	2x38	lpa1_off	33.3333	0	4	3	6
6	2x45	lpa1_off	100	0	4	3	9
7	3x32	lpa1_off	0	0	4	1	6
8	3x50	lpa1_off	100	0	5	3	9
9	4x49	lpa1_off	0	0	5	3	7
10	E2.W186	lpa1_off	33.3333	0	4	3	6
11	E2.M198	lpa1_off	100	50	4	3	3
12	6x45	lpa1_off	0	0	4	3	6
13	7x42	lpa1_off	33.3333	0	5	2	7
14	7x56	lpa1_off	33.3333	0	4	3	7
15	Lig	Shared	100	100	14	13	0
16	NT.Y34	Shared	100	100	6	7	6
17	1x50	Shared	100	50	4	4	9
18	I1x50	Shared	100	100	6	5	8
19	2x46	Shared	0	50	4	4	9
20	3x25	Shared	100	100	6	5	9
21	3x33	Shared	0	100	4	4	5
22	3x51	Shared	33.3333	50	4	4	7
23	E2.Y202	Shared	100	100	7	7	4
24	5x39	Shared	100	50	5	4	7
25	5x43	Shared	100	100	5	4	6
26	5x47	Shared	100	100	4	4	7
27	5x58	Shared	33.3333	0	4	4	9
28	6x44	Shared	100	50	4	4	9
29	6x48	Shared	100	100	5	6	8
30	7x37	Shared	100	50	4	4	5
31	8x54	Shared	66.6667	0	4	4	6
32	NT.N46	lpa1_on	0	0	3	5	2
33	1x40	lpa1_on	0	0	2	4	4
34	1x60	lpa1_on	0	0	3	4	6
35	2x50	lpa1_on	0	100	3	5	9
36	2x52	lpa1_on	0	0	3	4	7
37	2x57	lpa1_on	0	100	3	5	7
38	3x28	lpa1_on	66.6667	100	3	7	6
39	3x29	lpa1_on	0	50	3	4	4
40	3x34	lpa1_on	0	0	2	4	6
41	3x42	lpa1_on	0	50	3	4	8
42	3x43	lpa1_on	0	0	3	4	8
43	3x49	lpa1_on	0	0	3	4	8
44	3x55	lpa1_on	0	50	3	4	6
45	E2.I189	lpa1_on	0	50	2	4	3
46	5x62	lpa1_on	0	0	1	4	6
47	6x30	lpa1_on	0	0	2	4	7
48	6x58	lpa1_on	0	100	3	4	4
49	7x30	lpa1_on	0	0	0	4	4
50	7x53	lpa1_on	0	100	2	6	9
51	8x50	lpa1_on	0	0	3	4	8

Orange: nodes, hubs and links specific of lpa1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of lpa1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	lpa1_off Recurrence	lpa1_on Recurrence	lpa1_off Hub1?	lpa1_on Hub1?	lpa1_off Hub2?	lpa1_on Hub2?	ConSurf1	ConSurf2
1	6x48	Lig	lpa1_off	97.4875	0	Yes	Yes	Yes	Yes	8	0
2	E1.T109	Lig	lpa1_off	19.4124	7.7631	No	No	Yes	Yes	5	0
3	3x26	E2.N187	lpa1_off	13.2066	0	No	No	No	No	5	6
4	Lig	NT.K39	lpa1_off	10.8015	0.880759	Yes	Yes	Yes	No	0	8
5	E1.T109	E1x47	lpa1_off	18.4822	6.9755	No	No	No	No	5	5
6	E1x48	NT.W45	lpa1_off	17.0748	4.67197	No	No	Yes	No	4	1
7	E1x47	E1x48	lpa1_off	19.476	5.82656	No	No	No	No	5	4
8	2x57	3x32	lpa1_off	12.6779	0	No	Yes	Yes	No	7	6
9	3x32	Lig	lpa1_off	22.247	0	Yes	No	Yes	Yes	6	0
10	2x46	7x49	lpa1_off	87.8866	0	Yes	Yes	No	No	9	9
11	2x46	3x43	lpa1_off	95.0823	9.10682	Yes	Yes	No	Yes	9	8
12	3x43	6x44	lpa1_off	100	0	No	Yes	Yes	Yes	8	9
13	2x50	7x46	lpa1_off	10.4914	1.17999	No	Yes	No	No	9	9
14	1x47	2x54	lpa1_off	14.2443	0	No	No	No	No	6	7
15	1x46	2x54	lpa1_off	16.6176	1.19693	No	No	No	No	8	7
16	8x50	8x54	lpa1_off	10.4914	5.72211	No	Yes	Yes	Yes	8	6
17	2x40	I1x50	lpa1_off	21.4956	7.61631	No	No	Yes	Yes	9	8
18	2x40	6x33	lpa1_off	38.634	0	No	No	No	No	9	7
19	2x43	6x33	lpa1_off	64.8923	0	No	No	No	No	8	7
20	2x43	7x53	lpa1_off	65.6834	1.44535	No	No	No	Yes	8	9
21	6x40	7x53	lpa1_off	66.3513	4.14126	No	No	No	Yes	8	9
22	6x40	7x49	lpa1_off	73.3681	0	No	No	No	No	8	9
23	2x38	4x39	lpa1_off	24.0041	0	Yes	No	No	No	6	3
24	2x39	3x49	lpa1_off	36.2447	5.82656	No	No	No	Yes	8	8
25	2x39	2x40	lpa1_off	20.0803	6.3488	No	No	No	No	8	9
26	2x39	3x50	lpa1_off	19.2494	0	No	No	Yes	No	8	9
27	3x50	6x33	lpa1_off	26.783	0	Yes	No	No	No	9	7
28	5x58	6x41	lpa1_off	21.1775	0	Yes	Yes	No	No	9	7
29	3x43	6x41	lpa1_off	27.8445	0	No	Yes	No	No	8	7
30	2x45	3x42	lpa1_off	10.7856	5.01073	Yes	No	No	Yes	9	8
31	3x28	E1x52	lpa1_off	16.4507	4.59011	No	Yes	No	No	6	6
32	3x47	5x58	lpa1_off	14.618	2.08051	No	No	Yes	Yes	8	9
33	3x47	5x57	lpa1_off	13.4333	0	No	No	No	No	8	6
34	4x39	I2x55	lpa1_off	15.3852	0	No	No	No	No	3	3
35	5x39	5x43	lpa1_off	12.9085	0	Yes	Yes	Yes	Yes	7	6
36	6x55	Lig	lpa1_off	13.6082	1.10659	No	No	Yes	Yes	6	0
37	5x51	6x45	lpa1_off	13.5525	6.30646	No	No	Yes	No	5	6
38	5x51	6x44	lpa1_off	14.7372	8.90639	No	No	Yes	Yes	5	9
39	6x40	7x52	lpa1_off	11.0082	0	No	No	No	No	8	8
40	3x29	Lig	Shared	30.8301	26.8349	No	Yes	Yes	Yes	4	0
41	3x25	3x29	Shared	20.3109	15.9101	Yes	Yes	No	Yes	9	4
42	3x25	E2.L201	Shared	16.0054	32.382	Yes	Yes	No	No	9	1
43	E2.L201	NT.F33	Shared	13.7036	17.3668	No	No	No	No	1	6
44	NT.F32	NT.F33	Shared	12.4712	15.4302	Yes	No	No	No	2	6
45	3x26	E2.Y202	Shared	17.3094	10.2473	No	No	Yes	Yes	5	4
46	3x33	Lig	Shared	11.6641	24.6725	Yes	Yes	Yes	Yes	5	0
47	3x33	E2.Y202	Shared	11.4177	10.3263	Yes	Yes	Yes	Yes	5	4
48	1x50	2x50	Shared	17.7348	31.9049	Yes	Yes	No	Yes	9	9
49	2x50	7x49	Shared	29.2558	35.555	No	Yes	No	No	9	9
50	6x44	6x48	Shared	99.3798	52.4757	Yes	Yes	Yes	Yes	9	8
51	8x50	I1x50	Shared	11.5687	13.6207	No	Yes	Yes	Yes	8	8
52	2x38	3x49	Shared	30.2656	15.0463	Yes	No	No	Yes	6	8
53	2x46	3x42	Shared	19.2375	14.6087	Yes	Yes	No	Yes	9	8
54	3x25	3x28	Shared	11.4654	16.8925	Yes	Yes	No	Yes	9	6
55	5x43	Lig	Shared	17.2378	100	Yes	Yes	Yes	Yes	6	0
56	3x51	5x57	Shared	12.2406	63.6094	Yes	Yes	No	No	7	6
57	E2.I189	E2.L201	lpa1_on	0	13.7506	No	Yes	No	No	3	1
58	3x28	Lig	lpa1_on	0	23.4163	No	Yes	Yes	Yes	6	0
59	NT.L41	NT.Y34	lpa1_on	7.2235	11.0434	No	No	Yes	Yes	2	6
60	7x34	Lig	lpa1_on	1.19663	29.3953	No	No	Yes	Yes	4	0
61	7x34	E2.M198	lpa1_on	0.314065	29.9063	No	No	Yes	No	4	3
62	6x58	E2.M198	lpa1_on	3.91985	23.7099	No	Yes	Yes	No	4	3
63	2x57	7x38	lpa1_on	0	11.2494	No	Yes	No	No	7	6
64	7x38	Lig	lpa1_on	1.27614	12.2431	No	No	Yes	Yes	6	0
65	2x57	7x39	lpa1_on	0	15.1536	No	Yes	No	No	7	6
66	1x42	7x39	lpa1_on	0	11.7406	No	No	No	No	7	6
67	7x45	7x49	lpa1_on	0	58.3531	No	No	No	No	9	9
68	6x48	7x45	lpa1_on	0	60.4026	Yes	Yes	No	No	8	9
69	5x43	6x48	lpa1_on	0	99.0233	Yes	Yes	Yes	Yes	6	8
70	1x50	2x47	lpa1_on	1.24036	25.5815	Yes	Yes	No	No	9	9
71	1x57	8x50	lpa1_on	0	20.0542	No	No	No	Yes	7	8
72	1x53	1x57	lpa1_on	0	21.8948	No	No	No	No	9	7
73	1x53	2x47	lpa1_on	0	22.8122	No	No	No	No	9	9
74	4x42	4x43	lpa1_on	0	21.6943	No	No	No	No	7	1
75	4x43	4x47	lpa1_on	0	25.7848	No	No	No	No	1	4
76	4x47	4x48	lpa1_on	0	27.1963	No	No	No	No	4	3
77	4x48	4x52	lpa1_on	1.26819	30.0531	No	No	No	No	3	4
78	4x52	5x46	lpa1_on	0	31.4815	No	No	No	No	4	5
79	5x46	5x50	lpa1_on	0	32.9212	No	No	No	No	5	7
80	3x40	5x50	lpa1_on	2.97766	94.532	No	No	No	No	8	7
81	3x40	5x47	lpa1_on	4.45655	46.9089	No	No	Yes	Yes	8	7
82	5x47	6x48	lpa1_on	0	49.5907	Yes	Yes	Yes	Yes	7	8
83	3x40	6x44	lpa1_on	0	48.9386	No	No	Yes	Yes	8	9
84	2x38	4x42	lpa1_on	0	17.0562	Yes	No	No	No	6	7
85	3x43	7x53	lpa1_on	0	17.714	No	Yes	No	Yes	8	9
86	3x43	7x49	lpa1_on	0	25.096	No	Yes	No	No	8	9
87	3x34	4x53	lpa1_on	0	11.9523	No	Yes	No	No	6	8
88	3x37	4x53	lpa1_on	0	12.994	No	No	No	No	6	8
89	3x37	5x43	lpa1_on	4.28958	13.9425	No	No	Yes	Yes	6	6
90	2x46	2x50	lpa1_on	0	13.1465	Yes	Yes	No	Yes	9	9
91	2x57	7x42	lpa1_on	8.95683	15.5742	No	Yes	Yes	No	7	7
92	3x36	6x48	lpa1_on	4.55196	16.8756	No	No	Yes	Yes	7	8
93	3x44	5x50	lpa1_on	0	69.4586	No	No	No	No	7	7
94	5x53	5x57	lpa1_on	0	65.0802	No	No	No	No	5	6
95	3x44	5x53	lpa1_on	0	66.5453	No	No	No	No	7	5
96	3x51	3x55	lpa1_on	2.52445	32.5768	Yes	Yes	No	Yes	7	6
97	3x51	5x61	lpa1_on	7.39047	27.9754	Yes	Yes	No	No	7	9
98	3x54	3x55	lpa1_on	0	26.6147	No	No	No	Yes	8	6
99	3x54	5x61	lpa1_on	1.26421	26.6006	No	No	No	No	8	9
100	6x58	E2.S196	lpa1_on	0	10.9474	No	Yes	No	No	4	5
101	5x62	6x33	lpa1_on	0	41.0682	No	Yes	No	No	6	7
102	5x65	6x33	lpa1_on	0	43.8911	No	No	No	No	7	7
103	3x54	5x65	lpa1_on	0	50.0395	No	No	No	No	8	7
104	5x62	5x66	lpa1_on	0	28.3226	No	Yes	No	No	6	0
105	5x66	6x30	lpa1_on	0	25.1186	No	No	No	Yes	0	7
106	3x33	5x39	lpa1_on	0	12.6468	Yes	Yes	Yes	Yes	5	7
107	3x29	E2.Y202	lpa1_on	9.85927	10.5832	No	Yes	Yes	Yes	4	4
108	Lig	NT.Y34	lpa1_on	0	15.1056	Yes	Yes	Yes	Yes	0	6
109	3x36	7x42	lpa1_on	0	15.8085	No	No	Yes	No	7	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
E1.T109	Lig	Shared	6.85333	6.29	0	1	1	0
3x29	Lig	Shared	13.29	10.905	1	1	1	0
3x32	Lig	lpa1_off	4.85333	0	0	0	1	0
3x33	Lig	Shared	6.21333	6.28	1	1	1	0
E2.M198	Lig	lpa1_off	7.88333	0	1	0	1	0
5x43	Lig	Shared	5.61	10.54	1	1	1	0
6x48	Lig	lpa1_off	6.58667	0	0	1	1	0
6x51	Lig	lpa1_off	6.48333	0	0	0	1	0
6x55	Lig	Shared	11.6167	3.925	0	1	1	0
7x34	Lig	Shared	12.6633	14.535	1	1	1	0
7x35	Lig	Shared	5.09667	8.53	0	1	1	0
7x38	Lig	Shared	14.0267	12.765	0	0	1	0
NT.I30	NT.Y34	Shared	8.86333	2.42	1	0	2	1
3x25	NT.I30	lpa1_off	6.26667	0	1	1	2	2
NT.K39	NT.Y34	Shared	5.97	8.36	1	1	1	1
NT.L41	NT.Y34	Shared	8.98667	5.865	0	0	2	1
E1x50	NT.Y34	Shared	4.99	4.37	0	1	1	1
3x25	NT.Y34	lpa1_off	9.65	0	1	1	2	1
E2.P200	NT.Y34	Shared	19.0067	7.65	0	0	2	1
NT.H40	NT.K39	lpa1_off	5.67667	0	0	0	2	1
7x34	NT.K39	Shared	9	4.725	1	1	1	1
2x60	3x28	Shared	4.86	6.68	0	0	2	1
2x60	3x32	lpa1_off	5.71	0	0	0	2	1
2x63	E1x52	lpa1_off	12.36	0	0	0	2	2
3x28	E1x52	Shared	4.86	4.86	0	1	1	2
3x25	3x28	Shared	9.33333	7	1	1	2	1
3x25	3x29	Shared	10.5867	15.33	1	1	2	1
3x25	E2.Y202	Shared	5.46667	3.86	1	1	2	2
3x29	E2.Y202	Shared	9.02	6.765	1	1	1	2
3x33	E2.Y202	Shared	6.13333	6.9	1	1	1	2
3x33	5x43	lpa1_off	6.7	0	1	1	1	1
3x36	5x47	lpa1_off	5.49	0	0	0	2	2
3x36	6x48	Shared	12.91	6.83	0	0	2	1
3x37	4x56	Shared	9.03	6.025	0	1	2	2
3x37	5x43	Shared	6.06	6.06	0	1	2	1
5x40	E2.S196	lpa1_off	4.5	0	0	1	1	2
6x54	E2.M198	Shared	7.07	4.945	0	0	2	1
6x58	E2.M198	Shared	7.39333	9.01	0	0	2	1
7x34	E2.M198	Shared	6.76667	11.505	1	1	1	1
5x39	E2.Y202	Shared	4.96	5.46	1	1	2	2
5x39	5x43	lpa1_off	9.96667	0	1	1	2	1
5x40	6x55	Shared	4.15	4.845	0	1	1	1
5x43	5x47	lpa1_off	7.91	0	1	1	1	2
6x44	6x48	Shared	16.0367	16.54	0	1	2	1
6x44	7x45	lpa1_off	7.65333	0	0	1	2	2
6x47	6x48	lpa1_off	3.92	0	0	0	2	1
6x47	7x45	Shared	5.77333	9.45	0	0	2	2
6x48	7x41	Shared	10.37	3.24	0	1	1	2
6x51	7x37	Shared	4.52	3.01	0	0	1	2
6x54	7x37	Shared	9.74	8.525	0	0	2	2
Lig	NT.K39	Shared	4.55333	10.03	1	1	0	1
2x57	3x32	lpa1_off	3.63	0	0	0	2	1
2x56	3x32	Shared	2.16333	3.25	0	0	2	1
1x35	Lig	lpa1_off	1.82333	0	0	0	1	0
E1.T109	E1x47	Shared	1.82	3.64	0	1	1	2
E1x47	E1x50	lpa1_off	1.82	0	0	0	2	1
3x30	3x33	Shared	1.68	4.19	0	0	2	1
7x35	7x36	lpa1_off	1.65333	0	0	1	1	2
5x44	6x55	lpa1_off	1.58	0	0	0	2	1
Lig	NT.Y34	lpa1_on	0	3.335	1	1	0	1
1x35	7x35	lpa1_on	0	8.35	0	0	1	1
2x57	7x38	lpa1_on	0	9.965	0	0	2	1
2x63	3x28	lpa1_on	0	4.82	0	0	2	1
7x35	E1.T109	lpa1_on	0	4.505	0	1	1	1
3x28	E1x50	lpa1_on	0	4.525	0	1	1	1
E1x50	Lig	lpa1_on	0	6.84	0	1	1	0
3x25	E2.P200	lpa1_on	0	3.375	1	1	2	2
3x28	Lig	lpa1_on	0	6.47	0	1	1	0
3x33	5x39	lpa1_on	0	6.9	1	1	1	2
4x56	5x43	lpa1_on	0	4.07	0	1	2	1
6x58	E2.S196	lpa1_on	0	5.155	0	0	2	2
5x40	Lig	lpa1_on	0	3.935	0	1	1	0
5x43	6x48	lpa1_on	0	5.155	1	1	1	1
5x47	6x44	lpa1_on	0	7.25	0	1	2	2
5x47	6x48	lpa1_on	0	7.91	0	1	2	1
6x48	7x45	lpa1_on	0	10.735	0	1	1	2
3x28	3x29	lpa1_on	0	4.675	0	1	1	1
1x35	7x36	lpa1_on	0	0.655	0	0	1	2
NT.N35	NT.Y34	lpa1_on	0	0.58	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	lpa1_off	4Z36-LPA₁-ONO-3080573 4Z35-LPA₁-ONO-9910539 4Z34-LPA₁-ONO-9780307
	lpa1_on	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2

Network Difference
Value	lpa1_off	lpa1_on
I_min	3.80333	3.07
Number of Linked Nodes	277	285
Number of Specific Nodes	13 (4.69%)	21 (7.37%)
Number of Shared Nodes	264 (95.31%)	264 (92.63%)
Number of Links	299	314
Number of Specific Links	143 (47.83%)	158 (50.32%)
Number of Shared Links	156 (52.17%)	156 (49.68%)
Number of Hubs	31	37
Number of Specific Hubs	14 (45.16%)	20 (54.05%)
Number of Shared Hubs	17 (54.84%)	17 (45.95%)
Average % Shared Neighbours (Jaccard)	34.51
Average % Shared Neighbours (Otsuka)	44.39
Average % Shared Neighbours (Overlap Coefficient)	53.56
Average % Shared Cliques (k3-6)	78.33
Graphlets Similarity	0.503514

Paths Difference
Value	lpa1_off	lpa1_on
Number Of Nodes in MetaPath	57	66
Specific Nodes in MetaPath	28 (49.12%)	37 (56.06%)
Shared Nodes in MetaPath	264 (95.31%)	264 (95.31%)
Number Of Links MetaPath	56	70
Specific Links in MetaPath	39 (69.64%)	53 (75.71%)
Shared Links in MetaPath	156 (52.17%)	156 (52.17%)
Number of Shortest Paths	48586	74984
Length Of Smallest Path	3	3
Average Path Length	13.103	14.5928
Length of Longest Path	28	31
Minimum Path Strength	0.973333	0.68
Average Path Strength	6.76859	6.21542
Maximum Path Strength	16.38	16.5633
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.91403	0.927079
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.34783	3.7037
Average % Of Corr. Nodes	45.729	47.2507
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	35.3261	38.7484
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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