psnGPCR

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Orange: nodes, hubs and links specific of lpl_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of lpl_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	lpl_off Int. Strength	lpl_on Int. Strength	lpl_off Hub1?	lpl_on Hub1?	lpl_off Hub2?	lpl_on Hub2?	ConSurf1	ConSurf2
1	2x57	Lig	lpl_off	100	0	Yes	Yes	Yes	Yes	6	0
2	3x32	Lig	lpl_off	100	0	No	No	Yes	Yes	6	0
3	6x48	Lig	lpl_off	100	0	Yes	Yes	Yes	Yes	8	0
4	3x21	NT	lpl_off	100	0	No	No	Yes	Yes	7	6
5	1x39	2x61	lpl_off	100	0	No	No	No	No	6	5
6	1x40	2x61	lpl_off	100	0	No	No	No	No	3	5
7	1x46	7x46	lpl_off	100	0	No	Yes	No	No	7	9
8	1x57	I1x50	lpl_off	100	0	No	No	Yes	Yes	7	8
9	2x39	2x40	lpl_off	100	0	Yes	No	No	Yes	8	9
10	2x39	3x50	lpl_off	100	0	Yes	No	Yes	No	8	9
11	2x39	6x33	lpl_off	100	0	Yes	No	No	No	8	8
12	2x40	6x33	lpl_off	100	0	No	Yes	No	No	9	8
13	2x46	7x49	lpl_off	100	0	No	No	No	No	9	9
14	2x49	3x39	lpl_off	100	0	No	No	No	No	8	9
15	2x60	3x29	lpl_off	100	0	No	No	Yes	Yes	5	5
16	2x63	E1x52	lpl_off	100	0	No	No	No	No	4	5
17	3x33	5x43	lpl_off	100	0	Yes	Yes	No	No	5	6
18	3x36	5x47	lpl_off	100	0	No	No	Yes	No	6	7
19	3x40	5x47	lpl_off	100	0	No	No	Yes	No	7	7
20	3x43	6x41	lpl_off	100	0	No	No	No	No	9	7
21	3x43	6x44	lpl_off	100	0	No	No	Yes	Yes	9	9
22	3x46	6x37	lpl_off	100	0	No	No	No	No	8	8
23	3x50	3x53	lpl_off	100	0	Yes	No	No	No	9	8
24	3x50	6x33	lpl_off	100	0	Yes	No	No	No	9	8
25	3x50	6x34	lpl_off	100	0	Yes	No	No	No	9	8
26	4x59	5x39	lpl_off	100	0	No	No	Yes	Yes	5	7
27	5x42	E2	lpl_off	100	0	No	No	Yes	Yes	5	4
28	5x40	E2	lpl_off	100	0	No	No	Yes	Yes	6	4
29	5x43	5x47	lpl_off	100	0	No	No	Yes	No	6	7
30	5x44	6x56	lpl_off	100	0	No	No	No	No	5	6
31	5x54	6x41	lpl_off	100	0	No	No	No	No	8	7
32	5x58	6x38	lpl_off	100	0	Yes	No	No	No	9	5
33	5x58	6x41	lpl_off	100	0	Yes	No	No	No	9	7
34	6x39	7x56	lpl_off	100	0	No	No	Yes	No	6	7
35	6x40	7x49	lpl_off	100	0	No	No	No	No	8	9
36	6x40	7x52	lpl_off	100	0	No	No	No	No	8	8
37	6x48	6x52	lpl_off	100	0	Yes	Yes	No	Yes	8	6
38	6x54	7x31	lpl_off	100	0	Yes	No	No	No	4	3
39	6x57	6x61	lpl_off	100	0	No	No	No	No	4	4
40	E3	E3	lpl_off	100	0	Yes	No	Yes	No	2	2
41	8x47	8x50	lpl_off	100	0	No	No	No	Yes	8	8
42	8x49	I1x50	lpl_off	100	0	No	No	Yes	Yes	7	8
43	6x54	E2	lpl_off	100	0	Yes	No	Yes	Yes	4	4
44	5x58	5x62	lpl_off	100	0	Yes	No	No	Yes	9	6
45	7x34	NT	lpl_off	100	0	No	No	Yes	Yes	4	6
46	3x37	5x47	lpl_off	50	0	No	Yes	Yes	No	6	7
47	7x29	7x33	lpl_off	50	0	No	No	No	No	3	4
48	2x52	3x34	lpl_off	75	0	No	No	No	No	6	5
49	2x59	3x27	lpl_off	50	0	No	No	No	No	7	4
50	7x45	7x48	lpl_off	50	0	Yes	Yes	No	No	9	5
51	2x64	3x28	lpl_off	50	0	No	No	Yes	Yes	4	6
52	4x38	I2x53	lpl_off	50	0	No	No	No	No	7	0
53	6x35	7x56	lpl_off	75	0	No	No	Yes	No	7	7
54	2x48	4x50	lpl_off	50	0	No	No	Yes	Yes	5	9
55	5x61	6x34	lpl_off	50	0	No	No	No	No	9	8
56	E1x49	NT	lpl_off	50	0	No	No	Yes	Yes	4	6
57	6x29	8x49	lpl_off	50	0	No	No	No	No	6	7
58	3x50	6x30	lpl_off	50	0	Yes	No	No	No	9	7
59	1x42	7x42	lpl_off	50	0	No	No	No	No	6	7
60	1x33	1x35	lpl_off	50	0	No	No	No	No	0	5
61	1x53	8x54	lpl_off	75	0	No	No	Yes	Yes	9	7
62	1x53	2x47	lpl_off	50	0	No	No	No	No	9	9
63	6x47	7x40	lpl_off	25	0	No	No	No	No	8	7
64	1x52	8x57	lpl_off	50	0	No	No	No	No	7	6
65	1x39	7x42	lpl_off	41.6667	0	No	No	No	No	6	7
66	2x53	2x57	lpl_off	25	0	No	No	Yes	Yes	8	6
67	7x54	8x54	lpl_off	25	0	No	No	Yes	Yes	7	7
68	6x26	I2x51	lpl_off	50	0	No	Yes	No	No	4	0
69	2x38	I2x53	lpl_off	50	0	No	No	No	No	7	0
70	4x56	5x46	lpl_off	50	0	No	No	No	No	5	5
71	7x36	7x37	lpl_off	50	0	No	No	Yes	No	3	4
72	3x49	3x52	lpl_off	50	0	Yes	Yes	No	No	9	4
73	1x42	7x43	lpl_off	0	0	No	No	No	No	6	6
74	5x44	6x55	lpl_off	25	0	No	No	No	No	5	6
75	5x48	6x49	lpl_off	50	0	No	No	No	No	4	6
76	4x54	4x58	lpl_off	50	0	No	No	No	No	4	4
77	2x41	4x43	lpl_off	50	0	Yes	No	No	No	4	2
78	2x37	I2x52	lpl_off	33.3333	0	No	No	No	No	7	0
79	1x36	NT	lpl_off	25	0	No	No	Yes	Yes	5	6
80	I2x54	I2x55	lpl_off	16.6667	0	No	No	No	No	0	0
81	1x54	2x51	lpl_off	0	0	No	No	No	No	8	6
82	7x39	7x43	lpl_off	25	0	No	No	No	No	5	6
83	1x45	7x51	lpl_off	16.6667	0	No	No	No	No	4	6
84	6x27	6x31	lpl_off	0	0	No	No	No	No	4	5
85	4x40	I2x55	lpl_off	16.6667	0	No	No	No	No	4	0
86	3x48	4x45	lpl_off	50	0	No	No	No	No	6	6
87	I2x54	I2x56	lpl_off	16.6667	0	No	No	No	No	0	0
88	4x63	E2	lpl_off	0	0	No	No	Yes	Yes	5	4
89	3x52	3x56	lpl_off	16.6667	0	No	No	No	No	4	6
90	7x32	E2	lpl_off	50	0	No	No	Yes	Yes	1	4
91	3x45	4x45	lpl_off	25	0	No	No	No	No	7	6
92	1x51	1x55	lpl_off	25	0	No	No	No	No	4	4
93	4x39	I2x55	lpl_off	16.6667	0	No	No	No	No	1	0
94	3x30	E2	lpl_off	0	0	No	No	Yes	Yes	6	4
95	7x54	8x51	lpl_off	0	0	No	No	No	No	7	8
96	1x38	1x42	lpl_off	0	0	No	No	No	No	5	6
97	1x44	2x58	lpl_off	0	0	No	No	No	No	5	6
98	5x65	6x31	lpl_off	0	0	No	No	No	No	8	5
99	6x54	7x30	lpl_off	0	0	Yes	No	No	No	4	3
100	4x40	4x44	lpl_off	0	0	No	No	No	No	4	3
101	6x32	6x35	lpl_off	16.6667	0	No	No	No	No	7	7
102	1x44	1x48	lpl_off	0	0	No	No	No	No	5	4
103	6x45	6x46	lpl_off	0	0	No	No	No	No	6	5
104	6x25	6x26	lpl_off	0	0	No	No	No	Yes	4	4
105	6x24	6x27	lpl_off	0	0	No	No	No	No	2	4
106	4x58	4x62	lpl_off	0	0	No	No	No	No	4	4
107	4x47	4x51	lpl_off	0	0	No	No	No	No	4	4
108	5x55	6x45	lpl_off	0	0	No	No	No	No	4	6
109	I2x50	I2x51	lpl_off	16.6667	0	No	No	No	No	0	0
110	3x54	5x68	lpl_off	0	0	No	No	No	No	8	7
111	1x36	1x37	lpl_off	0	0	No	No	No	No	5	5
112	5x41	6x60	lpl_off	0	0	No	No	No	No	5	4
113	6x38	6x42	lpl_off	0	0	No	No	No	No	5	5
114	5x63	5x64	lpl_off	0	0	No	No	No	No	3	6
115	8x57	8x58	lpl_off	0	0	No	No	No	No	6	0
116	8x51	8x55	lpl_off	0	0	No	No	No	No	8	3
117	8x58	8x59	lpl_off	0	0	No	No	No	No	0	0
118	Lig	NT	Shared	100	100	Yes	Yes	Yes	Yes	0	6
119	2x60	Lig	Shared	100	100	No	No	Yes	Yes	5	0
120	3x29	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
121	3x33	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
122	6x51	Lig	Shared	100	100	No	No	Yes	Yes	6	0
123	6x55	Lig	Shared	100	100	No	No	Yes	Yes	6	0
124	7x35	Lig	Shared	100	100	No	No	Yes	Yes	3	0
125	7x38	Lig	Shared	100	100	No	No	Yes	Yes	5	0
126	NT	NT	Shared	100	100	Yes	Yes	Yes	Yes	6	6
127	E2	NT	Shared	100	100	Yes	Yes	Yes	Yes	4	6
128	3x22	NT	Shared	100	100	No	No	Yes	Yes	3	6
129	E1x50	NT	Shared	100	100	No	No	Yes	Yes	5	6
130	E1x501	NT	Shared	100	100	No	No	Yes	Yes	5	6
131	3x25	NT	Shared	100	100	Yes	Yes	Yes	Yes	9	6
132	E3	NT	Shared	100	100	Yes	No	Yes	Yes	2	6
133	1x43	2x58	Shared	100	100	No	No	No	No	5	6
134	1x45	1x49	Shared	100	50	No	No	No	No	4	8
135	1x49	7x50	Shared	100	100	No	No	No	No	8	9
136	1x50	2x47	Shared	100	52.381	No	Yes	No	No	9	9
137	1x50	2x50	Shared	100	100	No	Yes	No	Yes	9	9
138	1x50	7x50	Shared	100	100	No	Yes	No	No	9	9
139	1x51	2x51	Shared	100	23.8095	No	No	No	No	4	6
140	1x52	8x54	Shared	100	100	No	No	Yes	Yes	7	7
141	1x60	I1x50	Shared	100	100	No	No	Yes	Yes	6	8
142	1x60	8x53	Shared	100	100	No	No	No	No	6	7
143	I1x49	I1x50	Shared	100	100	No	No	Yes	Yes	6	8
144	2x40	I1x50	Shared	100	100	No	Yes	Yes	Yes	9	8
145	8x50	I1x50	Shared	100	100	No	Yes	Yes	Yes	8	8
146	2x41	I1x51	Shared	100	100	Yes	No	No	No	4	7
147	2x37	2x38	Shared	100	54.7619	No	No	No	No	7	7
148	2x38	3x49	Shared	100	100	No	No	Yes	Yes	7	9
149	2x42	3x46	Shared	100	100	Yes	Yes	No	No	8	8
150	2x42	3x49	Shared	100	100	Yes	Yes	Yes	Yes	8	9
151	2x42	4x42	Shared	100	100	Yes	Yes	No	Yes	8	7
152	2x43	7x53	Shared	100	55.5556	No	No	No	Yes	8	9
153	2x45	3x42	Shared	100	100	No	No	No	No	9	8
154	2x45	4x46	Shared	100	100	No	No	No	No	9	7
155	2x45	4x50	Shared	100	100	No	No	Yes	Yes	9	9
156	2x46	3x42	Shared	100	100	No	No	No	No	9	8
157	2x46	3x43	Shared	100	100	No	No	No	No	9	9
158	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
159	2x50	7x49	Shared	100	100	No	Yes	No	No	9	9
160	2x57	3x32	Shared	100	100	Yes	Yes	No	No	6	6
161	2x57	7x42	Shared	100	100	Yes	Yes	No	No	6	7
162	2x60	3x28	Shared	100	100	No	No	Yes	Yes	5	6
163	3x28	E1x50	Shared	100	100	Yes	Yes	No	No	6	5
164	3x24	E1x52	Shared	100	100	No	No	No	No	4	5
165	3x28	E1x52	Shared	100	100	Yes	Yes	No	No	6	5
166	3x21	3x24	Shared	100	100	No	No	No	No	7	4
167	3x25	3x28	Shared	100	100	Yes	Yes	Yes	Yes	9	6
168	3x25	3x29	Shared	100	100	Yes	Yes	Yes	Yes	9	5
169	3x25	E2	Shared	100	100	Yes	Yes	Yes	Yes	9	4
170	3x26	E2	Shared	100	100	No	No	Yes	Yes	6	4
171	3x28	3x29	Shared	100	100	Yes	Yes	Yes	Yes	6	5
172	3x29	E2	Shared	100	100	Yes	Yes	Yes	Yes	5	4
173	3x33	E2	Shared	100	100	Yes	Yes	Yes	Yes	5	4
174	3x33	5x39	Shared	100	100	Yes	Yes	Yes	Yes	5	7
175	3x36	6x48	Shared	100	100	No	No	Yes	Yes	6	8
176	3x37	4x53	Shared	100	58.3333	No	Yes	No	No	6	8
177	3x37	4x56	Shared	100	100	No	Yes	No	No	6	5
178	3x38	4x50	Shared	100	100	No	No	Yes	Yes	7	9
179	3x40	5x50	Shared	100	100	No	No	No	No	7	8
180	3x44	5x54	Shared	100	100	No	Yes	No	No	7	8
181	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	6
182	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	5
183	3x51	5x61	Shared	100	100	Yes	Yes	No	No	8	9
184	4x59	E2	Shared	100	100	No	No	Yes	Yes	5	4
185	4x60	E2	Shared	100	100	No	No	Yes	Yes	5	4
186	4x60	5x39	Shared	100	100	No	No	Yes	Yes	5	7
187	5x36	E2	Shared	100	100	No	No	Yes	Yes	4	4
188	5x38	E2	Shared	100	100	No	No	Yes	Yes	4	4
189	5x39	E2	Shared	100	100	Yes	Yes	Yes	Yes	7	4
190	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	4	4
191	6x58	E2	Shared	100	100	No	No	Yes	Yes	4	4
192	7x31	E2	Shared	100	100	No	No	Yes	Yes	3	4
193	7x34	E2	Shared	100	100	No	No	Yes	Yes	4	4
194	5x36	5x38	Shared	100	100	No	No	No	No	4	4
195	5x37	6x59	Shared	100	100	No	No	No	No	3	4
196	5x39	5x43	Shared	100	100	Yes	Yes	No	No	7	6
197	5x40	6x55	Shared	100	100	No	No	No	No	6	6
198	5x41	6x59	Shared	100	66.6667	No	No	No	No	5	4
199	5x47	6x52	Shared	100	100	Yes	No	No	Yes	7	6
200	5x51	6x44	Shared	100	100	No	No	Yes	Yes	5	9
201	5x51	6x45	Shared	100	100	No	No	No	No	5	6
202	6x36	7x56	Shared	100	100	No	No	Yes	No	9	7
203	6x39	7x52	Shared	100	4.7619	No	No	No	No	6	8
204	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
205	6x44	7x45	Shared	100	100	Yes	Yes	Yes	Yes	9	9
206	6x47	7x45	Shared	100	100	No	No	Yes	Yes	8	9
207	6x48	7x41	Shared	100	71.4286	Yes	Yes	No	No	8	7
208	6x48	7x45	Shared	100	100	Yes	Yes	Yes	Yes	8	9
209	6x50	7x37	Shared	100	100	No	No	Yes	No	9	4
210	6x54	7x37	Shared	100	100	Yes	No	Yes	No	4	4
211	6x58	7x31	Shared	100	100	No	No	No	No	4	3
212	6x61	E3	Shared	100	100	No	No	Yes	No	4	2
213	8x48	8x51	Shared	100	16.6667	No	No	No	No	6	8
214	E2	Lig	Shared	100	100	Yes	Yes	Yes	Yes	4	0
215	E1x48	NT	Shared	100	100	No	No	Yes	Yes	4	6
216	8x49	I1x49	Shared	100	100	No	No	No	No	7	6
217	5x62	6x34	Shared	100	100	No	Yes	No	No	6	8
218	7x55	7x56	Shared	100	100	No	No	Yes	No	6	7
219	7x34	Lig	Shared	100	100	No	No	Yes	Yes	4	0
220	3x42	4x49	Shared	100	100	No	No	No	No	8	6
221	3x55	5x64	Shared	100	100	No	No	No	No	6	6
222	4x41	I2x56	Shared	100	100	No	Yes	No	No	5	0
223	1x33	NT	Shared	75	0	No	No	Yes	Yes	0	6
224	2x52	4x50	Shared	50	30.5556	No	No	Yes	Yes	6	9
225	7x33	7x37	Shared	50	50	No	No	Yes	No	4	4
226	3x41	4x49	Shared	75	100	No	No	No	No	5	6
227	1x47	2x51	Shared	50	100	No	No	No	No	6	6
228	6x40	7x53	Shared	50	100	No	No	No	Yes	8	9
229	E1	Lig	Shared	50	100	No	No	Yes	Yes	0	0
230	3x26	4x61	Shared	66.6667	50	No	No	No	No	6	5
231	2x42	3x45	Shared	50	23.8095	Yes	Yes	No	No	8	7
232	3x47	5x58	Shared	25	100	No	No	Yes	No	8	9
233	1x40	2x58	Shared	50	100	No	No	No	No	3	6
234	3x21	3x23	Shared	50	44.0476	No	No	No	No	7	2
235	1x46	7x47	Shared	50	100	No	Yes	No	No	7	7
236	1x47	2x55	Shared	50	100	No	No	No	No	6	5
237	8x48	8x52	Shared	50	19.0476	No	No	No	No	6	5
238	2x59	2x63	Shared	50	100	No	No	No	No	7	4
239	5x62	5x66	Shared	50	100	No	Yes	No	No	6	5
240	2x39	3x49	Shared	50	100	Yes	No	Yes	Yes	8	9
241	E1x47	E1x48	Shared	25	66.6667	No	No	No	No	4	4
242	3x51	5x57	Shared	50	100	Yes	Yes	No	No	8	7
243	E1x49	E1x51	Shared	50	100	No	No	No	No	4	1
244	1x32	NT	Shared	50	50	No	No	Yes	Yes	0	6
245	3x34	4x57	Shared	0	5.55556	No	No	No	No	5	6
246	8x56	8x57	Shared	66.6667	0	No	No	No	No	4	6
247	3x41	4x52	Shared	41.6667	16.6667	No	No	No	No	5	4
248	1x54	2x47	Shared	50	50	No	No	No	No	8	9
249	6x43	7x48	Shared	25	11.1111	No	No	No	No	7	5
250	6x26	6x29	Shared	50	16.6667	No	Yes	No	No	4	6
251	2x53	3x35	Shared	0	50	No	No	No	No	8	6
252	3x54	5x61	Shared	50	100	No	No	No	No	8	9
253	5x37	E2	Shared	50	100	No	No	Yes	Yes	3	4
254	2x49	4x50	Shared	50	50	No	No	Yes	Yes	8	9
255	5x41	5x45	Shared	50	50	No	No	No	No	5	4
256	6x49	6x50	Shared	25	100	No	No	No	No	6	9
257	1x56	8x54	Shared	25	46.4286	No	No	Yes	Yes	8	7
258	1x31	NT	Shared	50	50	No	No	Yes	Yes	0	6
259	2x56	3x31	Shared	0	55.5556	No	No	No	No	4	4
260	2x41	4x39	Shared	50	100	Yes	No	No	No	4	1
261	1x46	2x54	Shared	25	50	No	Yes	No	No	7	7
262	2x41	4x42	Shared	25	100	Yes	No	No	Yes	4	7
263	1x59	1x60	Shared	50	0	No	Yes	No	No	6	6
264	1x58	1x59	Shared	0	4.7619	No	No	No	Yes	3	6
265	4x55	4x59	Shared	0	50	No	No	No	No	4	5
266	6x53	6x57	Shared	0	11.1111	No	No	No	No	5	4
267	1x57	2x44	Shared	0	100	No	No	No	No	7	5
268	3x54	5x65	Shared	25	9.52381	No	No	No	No	8	8
269	1x36	2x62	Shared	0	50	No	No	No	No	5	6
270	3x34	4x54	Shared	25	100	No	No	No	No	5	4
271	2x56	3x32	Shared	0	66.6667	No	No	No	No	4	6
272	I1x48	I1x51	Shared	16.6667	16.6667	No	No	No	No	6	7
273	5x52	5x56	Shared	25	0	No	No	No	No	4	4
274	5x45	5x49	Shared	0	0	No	No	No	No	4	5
275	1x30	NT	Shared	0	25	No	No	Yes	Yes	0	6
276	4x48	4x52	Shared	0	11.1111	No	No	No	No	3	4
277	6x59	6x60	Shared	0	29.7619	No	No	No	No	4	4
278	6x28	6x31	Shared	0	2.38095	No	Yes	No	No	5	5
279	4x51	4x55	Shared	0	5.55556	No	No	No	No	4	4
280	3x28	Lig	lpl_on	0	100	Yes	Yes	Yes	Yes	6	0
281	3x36	Lig	lpl_on	0	100	No	No	Yes	Yes	6	0
282	3x37	Lig	lpl_on	0	100	No	Yes	Yes	Yes	6	0
283	1x39	2x57	lpl_on	0	100	No	No	Yes	Yes	6	6
284	1x39	7x39	lpl_on	0	100	No	No	No	No	6	5
285	1x43	2x57	lpl_on	0	100	No	No	Yes	Yes	5	6
286	1x46	1x50	lpl_on	0	100	No	Yes	No	Yes	7	9
287	1x50	2x51	lpl_on	0	100	No	Yes	No	No	9	6
288	2x37	2x40	lpl_on	0	100	No	No	No	Yes	7	9
289	2x38	4x42	lpl_on	0	100	No	No	No	Yes	7	7
290	2x40	8x47	lpl_on	0	100	No	Yes	No	No	9	8
291	2x40	8x50	lpl_on	0	100	No	Yes	No	Yes	9	8
292	2x42	4x45	lpl_on	0	100	Yes	Yes	No	No	8	6
293	2x46	2x50	lpl_on	0	100	No	No	No	Yes	9	9
294	2x50	3x39	lpl_on	0	100	No	Yes	No	No	9	9
295	2x57	2x61	lpl_on	0	100	Yes	Yes	No	No	6	5
296	2x57	7x38	lpl_on	0	100	Yes	Yes	No	No	6	5
297	2x57	7x39	lpl_on	0	100	Yes	Yes	No	No	6	5
298	2x63	3x28	lpl_on	0	100	No	No	Yes	Yes	4	6
299	3x40	6x48	lpl_on	0	100	No	No	Yes	Yes	7	8
300	3x43	7x49	lpl_on	0	100	No	No	No	No	9	9
301	3x43	7x53	lpl_on	0	100	No	No	No	Yes	9	9
302	3x44	3x48	lpl_on	0	100	No	Yes	No	No	7	6
303	3x44	5x50	lpl_on	0	100	No	Yes	No	No	7	8
304	3x46	3x50	lpl_on	0	100	No	No	Yes	No	8	9
305	3x46	7x53	lpl_on	0	100	No	No	No	Yes	8	9
306	3x50	5x58	lpl_on	0	100	Yes	No	Yes	No	9	9
307	3x50	7x53	lpl_on	0	100	Yes	No	No	Yes	9	9
308	3x52	4x41	lpl_on	0	100	No	No	No	Yes	4	5
309	5x68	I2x50	lpl_on	0	100	No	No	No	No	7	0
310	I2x52	I2x53	lpl_on	0	100	No	No	No	No	0	0
311	4x38	4x40	lpl_on	0	100	No	No	No	No	7	4
312	4x59	4x60	lpl_on	0	100	No	No	No	No	5	5
313	5x44	6x52	lpl_on	0	100	No	No	No	Yes	5	6
314	5x47	6x44	lpl_on	0	100	Yes	No	Yes	Yes	7	9
315	5x47	6x48	lpl_on	0	100	Yes	No	Yes	Yes	7	8
316	5x51	5x55	lpl_on	0	100	No	No	No	No	5	4
317	5x55	6x41	lpl_on	0	100	No	No	No	No	4	7
318	5x58	6x37	lpl_on	0	100	Yes	No	No	No	9	8
319	5x62	6x33	lpl_on	0	100	No	Yes	No	No	6	8
320	5x64	5x68	lpl_on	0	100	No	No	No	No	6	7
321	5x65	6x33	lpl_on	0	100	No	No	No	No	8	8
322	5x66	6x30	lpl_on	0	100	No	No	No	No	5	7
323	6x28	6x30	lpl_on	0	100	No	Yes	No	No	5	7
324	6x50	7x40	lpl_on	0	100	No	No	No	No	9	7
325	7x32	7x33	lpl_on	0	100	No	No	No	No	1	4
326	7x43	7x48	lpl_on	0	100	No	No	No	No	6	5
327	7x45	7x49	lpl_on	0	100	Yes	Yes	No	No	9	9
328	7x52	7x53	lpl_on	0	100	No	No	No	Yes	8	9
329	7x54	8x50	lpl_on	0	100	No	No	No	Yes	7	8
330	E1x50	Lig	lpl_on	0	100	No	No	Yes	Yes	5	0
331	I2x51	I2x54	lpl_on	0	100	No	No	No	No	0	0
332	1x35	7x35	lpl_on	0	100	No	No	No	No	5	3
333	5x43	Lig	lpl_on	0	100	No	No	Yes	Yes	6	0
334	3x36	7x42	lpl_on	0	100	No	No	No	No	6	7
335	5x46	5x50	lpl_on	0	100	No	No	No	No	5	8
336	3x55	5x60	lpl_on	0	100	No	No	No	No	6	5
337	6x45	6x49	lpl_on	0	100	No	No	No	No	6	6
338	3x53	3x56	lpl_on	0	100	No	No	No	No	8	6
339	3x56	I2x54	lpl_on	0	100	No	No	No	No	6	0
340	3x37	5x43	lpl_on	0	100	No	Yes	No	No	6	6
341	6x32	7x56	lpl_on	0	100	No	No	Yes	No	7	7
342	6x58	7x30	lpl_on	0	100	No	No	No	No	4	3
343	1x57	2x40	lpl_on	0	50	No	No	No	Yes	7	9
344	I2x53	I2x55	lpl_on	0	50	No	No	No	No	0	0
345	6x34	6x38	lpl_on	0	34.9206	No	No	No	No	8	5
346	1x53	7x50	lpl_on	0	50	No	No	No	No	9	9
347	8x50	8x54	lpl_on	0	50	No	Yes	Yes	Yes	8	7
348	4x56	5x42	lpl_on	0	50	No	No	No	No	5	5
349	3x30	3x33	lpl_on	0	50	No	No	Yes	Yes	6	5
350	7x33	7x36	lpl_on	0	50	No	No	No	No	4	3
351	3x44	5x53	lpl_on	0	26.1905	No	Yes	No	No	7	6
352	3x49	4x41	lpl_on	0	47.2222	Yes	Yes	No	Yes	9	5
353	4x38	4x41	lpl_on	0	50	No	No	No	Yes	7	5
354	1x42	1x46	lpl_on	0	69.0476	No	No	No	Yes	6	7
355	2x58	2x62	lpl_on	0	50	No	No	No	No	6	6
356	3x49	3x53	lpl_on	0	50	Yes	Yes	No	No	9	8
357	5x48	6x52	lpl_on	0	48.8095	No	No	No	Yes	4	6
358	3x48	5x57	lpl_on	0	23.8095	No	No	No	No	6	7
359	6x31	6x35	lpl_on	0	55.5556	No	No	No	No	5	7
360	3x34	4x53	lpl_on	0	48.8095	No	No	No	No	5	8
361	6x39	7x55	lpl_on	0	50	No	No	No	No	6	6
362	2x64	Lig	lpl_on	0	50	No	No	Yes	Yes	4	0
363	7x43	7x47	lpl_on	0	16.6667	No	No	No	No	6	7
364	6x52	6x56	lpl_on	0	50	No	Yes	No	No	6	6
365	6x57	7x30	lpl_on	0	25	No	No	No	No	4	3
366	2x53	2x54	lpl_on	0	0	No	No	No	No	8	7
367	1x59	8x57	lpl_on	0	50	No	Yes	No	No	6	6
368	5x62	5x63	lpl_on	0	16.6667	No	Yes	No	No	6	3
369	6x42	6x45	lpl_on	0	50	No	No	No	No	5	6
370	1x38	7x39	lpl_on	0	50	No	No	No	No	5	5
371	3x27	3x31	lpl_on	0	50	No	No	No	No	4	4
372	7x29	7x32	lpl_on	0	25	No	No	No	No	3	1
373	1x49	7x51	lpl_on	0	50	No	No	No	No	8	6
374	5x66	5x70	lpl_on	0	22.2222	No	No	No	No	5	0
375	4x42	4x43	lpl_on	0	16.6667	No	Yes	No	No	7	2
376	1x54	2x48	lpl_on	0	33.3333	No	No	No	No	8	5
377	1x34	1x38	lpl_on	0	25	No	No	No	No	4	5
378	1x48	1x52	lpl_on	0	7.14286	No	No	No	No	4	7
379	1x40	1x44	lpl_on	0	0	No	No	No	No	3	5
380	E1x48	E1x49	lpl_on	0	25	No	No	No	No	4	4
381	5x69	6x26	lpl_on	0	16.6667	No	No	No	Yes	0	4
382	4x61	4x62	lpl_on	0	10.3175	No	No	No	No	5	4
383	4x62	4x63	lpl_on	0	27.381	No	No	No	No	4	5
384	8x48	8x49	lpl_on	0	0	No	No	No	No	6	7
385	5x65	5x69	lpl_on	0	0	No	No	No	No	8	0
386	1x55	1x59	lpl_on	0	16.6667	No	No	No	Yes	4	6
387	6x23	6x26	lpl_on	0	16.6667	No	No	No	Yes	0	4
388	I2x51	I2x52	lpl_on	0	16.6667	No	No	No	No	0	0
389	1x37	1x40	lpl_on	0	0	No	No	No	No	5	3
390	6x46	6x47	lpl_on	0	0	No	No	No	No	5	8
391	5x73	I3	lpl_on	0	7.14286	No	No	No	No	0	0
392	6x27	6x28	lpl_on	0	19.0476	No	No	No	Yes	4	5
393	5x49	5x52	lpl_on	0	0	No	No	No	No	5	4
394	6x26	I3	lpl_on	0	16.6667	No	Yes	No	No	4	0
395	8x54	8x55	lpl_on	0	7.14286	Yes	Yes	No	No	7	3
396	4x44	4x48	lpl_on	0	0	No	No	No	No	3	3
397	1x41	1x42	lpl_on	0	2.38095	No	No	No	No	4	6
398	5x71	5x72	lpl_on	0	4.7619	No	No	No	No	0	0
399	4x43	4x47	lpl_on	0	0	No	No	No	No	2	4
400	4x47	4x48	lpl_on	0	0	No	No	No	No	4	3
401	6x25	6x28	lpl_on	0	5.55556	No	No	No	Yes	4	5
402	4x57	4x58	lpl_on	0	0	No	No	No	No	6	4
403	5x72	5x74	lpl_on	0	4.7619	No	No	No	No	0	0
404	5x55	5x59	lpl_on	0	0	No	No	No	No	4	3
405	6x24	6x25	lpl_on	0	5.55556	No	No	No	No	2	4
406	5x68	5x71	lpl_on	0	4.7619	No	No	No	No	7	0
407	5x67	5x71	lpl_on	0	2.38095	No	No	No	No	5	0

Orange: nodes, hubs and links specific of lpl_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of lpl_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	lpl_off Avg Int. Strength	lpl_on Avg Int. Strength	lpl_off Num Of Links	lpl_on Num Of Links	ConSurf
1	2x39	lpl_off	0	0	4	1	8
2	2x41	lpl_off	0	0	4	3	4
3	3x50	lpl_off	50	0	5	3	9
4	5x47	lpl_off	100	50	5	3	7
5	5x58	lpl_off	0	27.7778	4	3	9
6	6x54	lpl_off	0	0	4	1	4
7	E3	lpl_off	50	44.4444	4	2	2
8	7x37	lpl_off	50	0	4	3	4
9	7x56	lpl_off	16.6667	0	4	3	7
10	Lig	Shared	100	100	14	17	0
11	NT	Shared	100	100	18	14	6
12	I1x50	Shared	100	50	6	4	8
13	2x42	Shared	0	16.6667	4	5	8
14	2x57	Shared	50	77.7778	4	7	6
15	3x25	Shared	100	47.619	4	4	9
16	3x28	Shared	50	95.2381	6	7	6
17	3x29	Shared	50	45.6349	5	4	5
18	3x33	Shared	0	50	4	4	5
19	3x49	Shared	0	21.4286	4	5	9
20	3x51	Shared	0	25	4	4	8
21	4x50	Shared	0	0	5	4	9
22	E2	Shared	100	100	23	17	4
23	5x39	Shared	50	50	5	4	7
24	6x44	Shared	100	25	4	4	9
25	6x48	Shared	100	83.3333	6	6	8
26	7x45	Shared	0	23.8095	4	4	9
27	8x54	Shared	0	0	4	4	7
28	1x46	lpl_on	0	0	3	4	7
29	1x50	lpl_on	75	27.7778	3	5	9
30	1x59	lpl_on	0	0	2	4	6
31	2x40	lpl_on	0	19.8413	3	5	9
32	2x50	lpl_on	0	50	3	5	9
33	3x37	lpl_on	0	0	3	4	6
34	3x44	lpl_on	0	0	1	4	7
35	4x41	lpl_on	0	0	1	4	5
36	4x42	lpl_on	0	0	2	4	7
37	5x62	lpl_on	25	0	3	4	6
38	6x28	lpl_on	0	0	1	4	5
39	6x52	lpl_on	0	0	2	4	6
40	7x53	lpl_on	50	77.7778	2	6	9
41	8x50	lpl_on	0	0	2	4	8
42	6x26	lpl_on	0	0	3	4	4

Orange: nodes, hubs and links specific of lpl_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of lpl_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	lpl_off Recurrence	lpl_on Recurrence	lpl_off Hub1?	lpl_on Hub1?	lpl_off Hub2?	lpl_on Hub2?	ConSurf1	ConSurf2
1	1x39	7x42	lpl_off	10.4924	0	No	No	No	No	6	7
2	2x57	Lig	lpl_off	21.6124	0	Yes	Yes	Yes	Yes	6	0
3	2x46	7x49	lpl_off	52.2548	0	No	No	No	No	9	9
4	3x43	6x44	lpl_off	100	0	No	No	Yes	Yes	9	9
5	6x44	6x48	lpl_off	95.3201	9.37228	Yes	Yes	Yes	Yes	9	8
6	6x48	Lig	lpl_off	88.545	0	Yes	Yes	Yes	Yes	8	0
7	1x50	2x47	lpl_off	27.7228	5.00348	No	Yes	No	No	9	9
8	1x53	8x54	lpl_off	16.9964	0	No	No	Yes	Yes	9	7
9	1x53	2x47	lpl_off	18.3684	0	No	No	No	No	9	9
10	2x39	2x40	lpl_off	20.6073	0	Yes	No	No	Yes	8	9
11	2x39	3x50	lpl_off	47.7239	0	Yes	No	Yes	No	8	9
12	3x50	6x34	lpl_off	69.5756	0	Yes	No	No	No	9	8
13	5x62	6x34	lpl_off	79.866	2.62128	No	Yes	No	No	6	8
14	5x58	5x62	lpl_off	81.2274	0	Yes	No	No	Yes	9	6
15	5x58	6x41	lpl_off	83.6311	0	Yes	No	No	No	9	7
16	3x43	6x41	lpl_off	85.5456	0	No	No	No	No	9	7
17	2x40	6x33	lpl_off	18.5918	0	No	Yes	No	No	9	8
18	3x50	6x33	lpl_off	19.6873	0	Yes	No	No	No	9	8
19	2x41	4x42	lpl_off	13.9811	5.32951	Yes	No	No	Yes	4	7
20	2x39	3x49	lpl_off	30.5254	1.30847	Yes	No	Yes	Yes	8	9
21	6x40	7x49	lpl_off	14.1832	0	No	No	No	No	8	9
22	2x45	4x50	lpl_off	15.9647	7.99426	No	No	Yes	Yes	9	9
23	3x28	E1x52	lpl_off	11.79	6.22066	Yes	Yes	No	No	6	5
24	6x48	6x52	lpl_off	10.6733	0	Yes	Yes	No	Yes	8	6
25	3x37	5x47	lpl_off	14.013	0	No	Yes	Yes	No	6	7
26	5x61	6x34	lpl_off	18.0015	0	No	No	No	No	9	8
27	6x40	7x52	lpl_off	10.301	0	No	No	No	No	8	8
28	6x54	E2	lpl_off	12.024	0	Yes	No	Yes	Yes	4	4
29	8x49	I1x50	lpl_off	12.6569	0	No	No	Yes	Yes	7	8
30	6x29	8x49	lpl_off	10.7318	0	No	No	No	No	6	7
31	2x57	7x42	Shared	17.6718	15.7407	Yes	Yes	No	No	6	7
32	1x50	2x50	Shared	34.0779	36.3893	No	Yes	No	Yes	9	9
33	2x50	7x49	Shared	40.167	38.4803	No	Yes	No	No	9	9
34	2x46	3x43	Shared	70.3999	22.9786	No	No	No	No	9	9
35	2x40	I1x50	Shared	37.04	27.73	No	Yes	Yes	Yes	9	8
36	1x60	I1x50	Shared	10.3116	14.9105	No	No	Yes	Yes	6	8
37	2x42	4x42	Shared	14.9489	34.2158	Yes	Yes	No	Yes	8	7
38	2x42	3x49	Shared	21.8836	41.2146	Yes	Yes	Yes	Yes	8	9
39	2x45	3x42	Shared	18.3631	11.9414	No	No	No	No	9	8
40	2x46	3x42	Shared	25.0904	21.9266	No	No	No	No	9	8
41	Lig	NT	Shared	23.5907	13.8106	Yes	Yes	Yes	Yes	0	6
42	E2	Lig	Shared	32.4718	27.7126	Yes	Yes	Yes	Yes	4	0
43	3x36	6x48	Shared	10.6733	81.8075	No	No	Yes	Yes	6	8
44	1x46	1x50	lpl_on	0	16.3841	No	Yes	No	Yes	7	9
45	7x45	7x49	lpl_on	0	100	Yes	Yes	No	No	9	9
46	6x48	7x45	lpl_on	3.29185	86.924	Yes	Yes	Yes	Yes	8	9
47	3x36	Lig	lpl_on	0	64.8931	No	No	Yes	Yes	6	0
48	8x50	8x54	lpl_on	0	10.7633	No	Yes	Yes	Yes	8	7
49	2x40	8x50	lpl_on	0	14.5583	No	Yes	No	Yes	9	8
50	2x37	2x40	lpl_on	0	50.9346	No	No	No	Yes	7	9
51	2x37	2x38	lpl_on	2.46224	53.0777	No	No	No	No	7	7
52	2x38	3x49	lpl_on	5.94554	28.3125	No	No	Yes	Yes	7	9
53	2x42	3x46	lpl_on	2.69092	76.2824	Yes	Yes	No	No	8	8
54	3x46	7x53	lpl_on	0	75.7868	No	No	No	Yes	8	9
55	3x43	7x53	lpl_on	0	85.22	No	No	No	Yes	9	9
56	3x43	7x49	lpl_on	0	81.7597	No	No	No	No	9	9
57	2x38	4x42	lpl_on	0	28.2125	No	No	No	Yes	7	7
58	I1x49	I1x50	lpl_on	2.55797	11.2154	No	No	Yes	Yes	6	8
59	2x46	2x50	lpl_on	0	21.1876	No	No	No	Yes	9	9
60	3x36	7x42	lpl_on	0	16.9058	No	No	No	No	6	7
61	3x40	6x48	lpl_on	0	44.6227	No	No	Yes	Yes	7	8
62	3x40	5x50	lpl_on	3.51521	43.6489	No	No	No	No	7	8
63	3x44	5x50	lpl_on	0	41.6754	No	Yes	No	No	7	8
64	3x44	3x48	lpl_on	0	38.6498	No	Yes	No	No	7	6
65	3x51	5x57	lpl_on	1.49968	36.5893	Yes	Yes	No	No	8	7
66	3x48	5x57	lpl_on	0	37.6239	No	No	No	No	6	7
67	3x51	5x61	lpl_on	8.51415	26.1563	Yes	Yes	No	No	8	9
68	3x54	5x61	lpl_on	8.55137	25.0304	No	No	No	No	8	9
69	5x37	E2	lpl_on	8.83323	10.7068	No	No	Yes	Yes	3	4
70	5x51	6x44	lpl_on	5.95086	18.6576	No	No	Yes	Yes	5	9
71	5x51	6x45	lpl_on	4.47777	13.8063	No	No	No	No	5	6
72	5x62	6x33	lpl_on	0	15.7538	No	Yes	No	No	6	8
73	5x65	6x33	lpl_on	0	16.7188	No	No	No	No	8	8
74	3x54	5x65	lpl_on	6.33376	23.8567	No	No	No	No	8	8
75	5x62	5x66	lpl_on	1.10083	10.8372	No	Yes	No	No	6	5
76	6x45	6x49	lpl_on	0	11.3285	No	No	No	No	6	6
77	6x49	6x50	lpl_on	2.99404	10.0765	No	No	No	No	6	9
78	1x59	1x60	lpl_on	5.17443	10.746	No	Yes	No	No	6	6
79	6x44	7x45	lpl_on	4.11615	13.3194	Yes	Yes	Yes	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
Lig	NT	Shared	11.0767	10.0719	1	1	0	1
2x57	Lig	lpl_off	3.875	0	1	3	1	0
2x60	Lig	Shared	6.13583	5.2344	1	1	1	0
3x29	Lig	Shared	13.7875	9.34202	1	1	1	0
3x32	Lig	lpl_off	8.14917	0	1	0	1	0
3x33	Lig	Shared	7.04917	9.02016	1	1	1	0
6x48	Lig	lpl_off	5.00833	0	1	2	1	0
6x51	Lig	Shared	4.14667	3.41103	0	0	1	0
6x55	Lig	Shared	6.51583	3.98496	0	0	1	0
7x35	Lig	Shared	5.61583	4.33571	0	0	1	0
7x38	Lig	Shared	16.4833	9.6656	0	0	1	0
NT	NT	Shared	71.0592	60.3069	1	1	1	1
E2	NT	Shared	84.3683	66.0019	1	1	1	1
3x21	NT	lpl_off	4.52417	0	1	0	2	1
3x22	NT	Shared	6.3775	4.2923	0	0	2	1
E1x50	NT	Shared	7.09083	4.31762	1	1	1	1
E1x501	NT	Shared	16.4825	9.69111	0	0	2	1
3x25	NT	Shared	13.8183	3.47536	1	1	2	1
E3	NT	Shared	6.0575	3.21516	1	1	2	1
1x39	2x61	lpl_off	4.0475	0	0	3	2	2
2x57	3x32	Shared	4.26	3.07369	1	3	1	1
2x57	7x42	Shared	13.8225	13.7158	1	3	1	2
2x60	3x28	Shared	5.745	6.76571	1	1	1	1
2x60	3x29	lpl_off	3.945	0	1	1	1	1
2x63	E1x52	lpl_off	8.255	0	0	0	2	2
3x28	E1x50	Shared	5.495	4.46948	1	1	1	1
3x28	E1x52	Shared	5.1625	3.29683	1	1	1	2
3x25	3x28	Shared	9.16667	7.30952	1	1	2	1
3x25	3x29	Shared	9.10833	13.0479	1	1	2	1
3x25	E2	Shared	30.0433	17.7958	1	1	2	1
3x26	E2	Shared	14.96	10.4488	1	1	2	1
3x28	3x29	Shared	8.145	3.8979	1	1	1	1
3x29	E2	Shared	7.52	9.77361	1	1	1	1
3x33	E2	Shared	10.5192	5.23659	1	1	1	1
3x33	5x39	Shared	4.5625	7.33008	1	1	1	2
3x33	5x43	lpl_off	4.0475	0	1	1	1	1
3x36	5x47	lpl_off	6.4	0	0	0	1	2
3x36	6x48	Shared	14.71	5.96325	0	0	1	1
3x37	4x53	Shared	4.07	2.55333	0	1	1	2
3x37	4x56	Shared	7.1075	3.4056	0	1	1	2
3x40	5x47	lpl_off	5.49	0	0	0	2	2
4x59	E2	Shared	4.04	4.11548	1	1	2	1
4x59	5x39	lpl_off	3.865	0	1	1	2	2
4x60	E2	Shared	12.1725	10.3774	1	1	2	1
4x60	5x39	Shared	16.69	16.7893	1	1	2	2
5x36	E2	Shared	8.6125	4.78052	1	1	2	1
5x38	E2	Shared	5.145	6.51516	1	1	2	1
5x39	E2	Shared	18.6425	9.85778	1	1	2	1
5x42	E2	lpl_off	7.5175	0	0	0	2	1
E2	E2	Shared	46.03	42.3977	1	1	1	1
5x40	E2	lpl_off	8.125	0	1	0	2	1
6x58	E2	Shared	19.4742	19.8121	1	1	2	1
7x31	E2	Shared	4.99583	4.04167	1	1	2	1
7x34	E2	Shared	4.65583	6.57694	1	1	1	1
5x36	5x38	Shared	5.43	5.18964	1	1	2	2
5x39	5x43	Shared	9.68833	3.13861	1	1	2	1
5x40	6x55	Shared	4.9925	3.73306	1	0	2	1
5x43	5x47	lpl_off	5.35	0	1	1	1	2
5x47	6x52	Shared	5.5425	13.091	0	2	2	2
6x44	6x48	Shared	14.7833	11.7229	1	2	2	1
6x44	7x45	Shared	7.45167	3.02575	1	2	2	2
6x48	6x52	lpl_off	5.8325	0	1	2	1	2
6x48	7x41	Shared	9.7225	2.54619	1	2	1	2
6x48	7x45	Shared	4.04917	11.6901	1	2	1	2
6x54	7x31	lpl_off	4.155	0	1	0	2	2
6x58	7x31	Shared	7.465	3.46786	1	1	2	2
E3	E3	lpl_off	8.92833	0	1	1	2	2
E2	Lig	Shared	5.935	4.17413	1	1	1	0
E1x48	NT	Shared	12.2425	4.0525	1	1	2	1
6x54	E2	lpl_off	3.9075	0	1	0	2	1
7x34	Lig	Shared	6.33167	7.69655	1	1	1	0
7x34	NT	lpl_off	5.115	0	1	1	1	1
1x33	NT	Shared	3.6725	0.87	1	0	2	1
3x37	5x47	lpl_off	3.6725	0	0	1	1	2
E1	Lig	Shared	3.42667	3.145	0	0	1	0
2x64	3x28	lpl_off	3.2925	0	0	0	1	1
E1x49	NT	lpl_off	3.20167	0	1	0	2	1
1x33	1x35	lpl_off	2.9775	0	1	0	2	2
1x32	NT	Shared	2.76833	2.98	0	0	2	1
1x39	7x42	lpl_off	2.71833	0	0	3	2	2
2x53	2x57	lpl_off	2.67	0	0	0	2	1
5x37	E2	Shared	2.5475	3.41258	1	1	2	1
5x44	6x55	lpl_off	2.2725	0	0	0	2	1
1x31	NT	Shared	2.215	1.8475	0	0	2	1
1x36	NT	lpl_off	1.9525	0	1	0	2	1
4x63	E2	lpl_off	1.7	0	0	0	2	1
7x32	E2	lpl_off	1.665	0	0	0	2	1
2x56	3x32	Shared	1.48417	2.35611	0	0	2	1
3x30	E2	lpl_off	1.45	0	0	0	2	1
1x30	NT	Shared	0.73	1.0975	0	0	2	1
3x28	Lig	lpl_on	0	4.18492	1	1	1	0
3x36	Lig	lpl_on	0	5.13686	0	0	1	0
3x37	Lig	lpl_on	0	3.00071	0	1	1	0
1x39	2x57	lpl_on	0	3.22472	0	3	2	1
1x39	7x39	lpl_on	0	4.3131	0	3	2	2
1x43	2x57	lpl_on	0	3.53984	0	0	2	1
2x57	2x61	lpl_on	0	6.39603	1	3	1	2
2x57	7x38	lpl_on	0	8.90837	1	3	1	1
2x57	7x39	lpl_on	0	3.83286	1	3	1	2
2x63	3x28	lpl_on	0	5.9181	0	0	2	1
3x40	6x48	lpl_on	0	3.42036	0	0	2	1
4x59	4x60	lpl_on	0	3.07571	1	1	2	2
5x44	6x52	lpl_on	0	3.1529	0	0	2	2
5x47	6x44	lpl_on	0	4.10103	0	2	2	2
5x47	6x48	lpl_on	0	7.1996	0	2	2	1
E1x50	Lig	lpl_on	0	4.11325	1	1	1	0
1x35	7x35	lpl_on	0	5.0081	0	0	2	1
5x43	Lig	lpl_on	0	7.84079	1	1	1	0
3x36	7x42	lpl_on	0	3.58548	0	0	1	2
3x37	5x43	lpl_on	0	3.03	0	1	1	1
4x56	5x42	lpl_on	0	2.71933	0	0	2	2
3x30	3x33	lpl_on	0	2.65825	0	0	2	1
2x64	Lig	lpl_on	0	2.11198	0	0	1	0
E1x48	E1x49	lpl_on	0	1.24778	1	1	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	lpl_off	s1p_off lpa_off
	lpl_on	s1p_on lpa_on

Network Difference
Value	lpl_off	lpl_on
I_min	3.67583	2.98302
Number of Linked Nodes	250	261
Number of Specific Nodes	2 (0.80%)	13 (4.98%)
Number of Shared Nodes	248 (99.20%)	248 (95.02%)
Number of Links	279	290
Number of Specific Links	117 (41.94%)	128 (44.14%)
Number of Shared Links	162 (58.06%)	162 (55.86%)
Number of Hubs	27	33
Number of Specific Hubs	9 (33.33%)	15 (45.45%)
Number of Shared Hubs	18 (66.67%)	18 (54.55%)
Average % Shared Neighbours (Jaccard)	41.86
Average % Shared Neighbours (Otsuka)	50.65
Average % Shared Neighbours (Overlap Coefficient)	59.50
Average % Shared Cliques (k3-6)	58.57
Graphlets Similarity	0.663381

Paths Difference
Value	lpl_off	lpl_on
Number Of Nodes in MetaPath	45	48
Specific Nodes in MetaPath	20 (44.44%)	23 (47.92%)
Shared Nodes in MetaPath	248 (99.20%)	248 (99.20%)
Number Of Links MetaPath	43	49
Specific Links in MetaPath	30 (69.77%)	36 (73.47%)
Shared Links in MetaPath	162 (58.06%)	162 (58.06%)
Number of Shortest Paths	37019	44209
Length Of Smallest Path	3	3
Average Path Length	12.1135	13.2512
Length of Longest Path	27	32
Minimum Path Strength	0.32875	0.278214
Average Path Strength	6.42967	5.20313
Maximum Path Strength	51.5054	38.1897
Minimum Path Correlation	0.7	0.701984
Average Path Correlation	0.901187	0.907253
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.16667	3.44828
Average % Of Corr. Nodes	43.3128	46.5688
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	37.8451	40.3626
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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