psnGPCR

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Orange: nodes, hubs and links specific of m1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	m1_off Int. Strength	m1_on Int. Strength	m1_off Hub1?	m1_on Hub1?	m1_off Hub2?	m1_on Hub2?	ConSurf1	ConSurf2
1	1x31	NT.K20	m1_off	6.78	0	No	No	Yes	No	6	5
2	2x64	NT.K20	m1_off	4.23	0	No	No	Yes	No	7	5
3	7x35	NT.K20	m1_off	4.05	0	No	No	Yes	No	6	5
4	1x29	NT.G21	m1_off	4.06	0	No	No	No	No	2	6
5	1x32	2x65	m1_off	7.45	0	No	No	No	No	4	6
6	1x34	1x38	m1_off	5.19	0	No	No	No	No	3	4
7	1x35	2x65	m1_off	7.14	0	No	No	No	No	7	6
8	1x42	2x57	m1_off	4.24	0	No	No	Yes	No	7	8
9	1x42	7x47	m1_off	5.9	0	No	No	No	No	7	8
10	1x46	2x57	m1_off	4.52	0	No	No	Yes	No	8	8
11	1x49	7x50	m1_off	4.06	0	No	No	No	No	9	9
12	1x50	2x47	m1_off	4.69	0	Yes	Yes	No	No	9	9
13	1x51	1x55	m1_off	4.28	0	No	No	No	No	5	6
14	1x52	8x58	m1_off	6.92	0	No	No	No	No	8	8
15	1x53	7x53	m1_off	6.31	0	No	No	No	Yes	9	9
16	1x54	1x58	m1_off	4.23	0	No	No	No	No	7	5
17	1x55	8x57	m1_off	5.71	0	No	No	No	No	6	8
18	1x56	8x54	m1_off	5.28	0	No	No	Yes	No	9	9
19	I1x48	I1x51	m1_off	4.5	0	No	No	No	No	7	7
20	8x49	I1x49	m1_off	4.53	0	No	No	No	No	7	7
21	2x40	I1x50	m1_off	4.12	0	No	No	No	No	9	9
22	2x41	4x39	m1_off	5.56	0	No	No	No	No	7	5
23	2x42	3x46	m1_off	5.02	0	Yes	No	No	No	8	9
24	2x43	7x53	m1_off	21.1	0	No	No	No	Yes	9	9
25	2x45	4x50	m1_off	6.18	0	No	No	Yes	No	9	9
26	2x46	2x50	m1_off	4.07	0	No	No	Yes	Yes	9	9
27	2x53	2x54	m1_off	3.53	0	Yes	No	No	No	8	8
28	2x53	2x56	m1_off	7.74	0	Yes	No	No	No	8	8
29	2x53	7x42	m1_off	4.84	0	Yes	No	Yes	Yes	8	8
30	3x28	E2x50	m1_off	3.92	0	Yes	Yes	No	No	7	9
31	3x29	E2x52	m1_off	4.28	0	No	No	Yes	Yes	7	7
32	3x32	7x38	m1_off	4.6	0	Yes	No	Yes	Yes	9	7
33	3x37	3x40	m1_off	4.3	0	Yes	Yes	No	No	8	9
34	3x40	5x50	m1_off	3.53	0	No	No	No	No	9	9
35	3x43	6x41	m1_off	5.54	0	No	Yes	No	No	8	7
36	3x48	3x52	m1_off	5.36	0	No	No	Yes	No	7	7
37	3x50	5x61	m1_off	11.27	0	Yes	No	No	No	9	9
38	3x50	6x34	m1_off	4.15	0	Yes	No	No	No	9	8
39	3x50	6x37	m1_off	4.86	0	Yes	No	No	No	9	9
40	3x51	3x52	m1_off	6.19	0	Yes	No	Yes	No	8	7
41	3x51	3x56	m1_off	4.12	0	Yes	No	Yes	No	8	7
42	3x51	5x61	m1_off	4.84	0	Yes	No	No	No	8	9
43	3x52	3x56	m1_off	6.41	0	Yes	No	Yes	No	7	7
44	3x54	5x61	m1_off	4.61	0	No	No	No	No	8	9
45	3x54	5x68	m1_off	5.23	0	No	No	Yes	No	8	8
46	3x55	3x56	m1_off	10.35	0	No	No	Yes	No	8	7
47	3x55	5x64	m1_off	4.23	0	No	No	No	No	8	7
48	I2x53	I2x56	m1_off	3.58	0	Yes	Yes	No	No	9	6
49	4x41	I2x56	m1_off	4.95	0	No	No	No	No	8	6
50	4x41	4x45	m1_off	3.72	0	No	No	No	No	8	7
51	4x44	4x48	m1_off	4.15	0	No	No	No	No	2	4
52	4x46	4x47	m1_off	3.53	0	No	No	No	No	9	4
53	E2.L174	E2x51	m1_off	3.52	0	No	No	No	No	3	4
54	E2.F182	E2.L183	m1_off	7.31	0	Yes	Yes	Yes	No	6	7
55	5x40	E2.L183	m1_off	7.37	0	No	No	Yes	No	7	7
56	5x43	E2.L183	m1_off	4.42	0	No	No	Yes	No	8	7
57	5x36	5x37	m1_off	4.74	0	No	No	No	No	7	5
58	5x36	5x39	m1_off	5.49	0	No	No	No	No	7	8
59	5x41	6x55	m1_off	3.93	0	Yes	No	No	No	7	8
60	5x41	6x59	m1_off	5.19	0	Yes	No	No	No	7	8
61	5x43	Lig	m1_off	4.71	0	No	No	Yes	Yes	8	0
62	5x461	Lig	m1_off	4.02	0	No	No	Yes	Yes	8	0
63	5x47	6x44	m1_off	5.36	0	Yes	Yes	Yes	Yes	9	9
64	5x58	6x38	m1_off	5.09	0	No	Yes	No	No	9	7
65	5x59	5x60	m1_off	13.99	0	No	No	No	No	4	7
66	5x62	5x63	m1_off	15.43	0	No	Yes	No	No	7	5
67	5x65	5x68	m1_off	5.17	0	No	No	Yes	No	8	8
68	5x68	6x30	m1_off	12.79	0	Yes	No	No	No	8	9
69	6x25	6x27	m1_off	4.87	0	No	No	No	No	3	5
70	6x29	8x47	m1_off	6.99	0	No	No	No	No	7	9
71	6x36	7x53	m1_off	4.99	0	No	No	No	Yes	8	9
72	6x37	6x41	m1_off	6.92	0	No	No	No	No	9	7
73	6x40	7x49	m1_off	7.08	0	No	Yes	No	No	8	9
74	6x44	7x45	m1_off	3.62	0	Yes	Yes	No	No	9	9
75	6x47	7x40	m1_off	4.42	0	Yes	No	No	No	8	8
76	6x51	7x34	m1_off	6.75	0	No	Yes	Yes	Yes	8	7
77	6x52	Lig	m1_off	10.52	0	No	No	Yes	Yes	8	0
78	6x56	6x60	m1_off	4.87	0	No	No	No	No	7	5
79	7x33	E3.V395	m1_off	4.47	0	No	No	Yes	No	5	6
80	7x34	E3.V395	m1_off	9.81	0	Yes	Yes	Yes	No	7	6
81	7x30	7x33	m1_off	9.85	0	No	No	No	No	6	5
82	7x38	7x42	m1_off	6.95	0	Yes	Yes	Yes	Yes	7	8
83	7x54	8x54	m1_off	4.16	0	No	No	Yes	No	8	9
84	8x59	CT.R436	m1_off	14.58	0	No	No	No	No	5	4
85	6x54	7x37	m1_off	3.49	0	No	No	No	No	6	6
86	4x56	4x57	m1_off	3.42	0	No	No	Yes	Yes	8	8
87	1x31	NT.G21	m1_off	3.29	0	No	No	No	No	6	6
88	6x26	6x28	m1_off	3.23	0	No	No	No	No	6	5
89	7x55	7x56	m1_off	3.17	0	No	No	No	No	7	8
90	1x43	2x57	m1_off	3.07	0	No	No	Yes	No	7	8
91	3x41	4x53	m1_off	3.07	0	No	No	No	No	7	8
92	7x43	7x48	m1_off	3.07	0	No	No	No	No	7	6
93	1x32	NT.K20	m1_off	3.04	0	No	No	Yes	No	4	5
94	2x46	3x39	m1_off	3	0	No	No	No	No	9	9
95	1x42	7x43	m1_off	2.98	0	No	No	No	No	7	7
96	4x51	4x55	m1_off	2.98	0	No	No	No	No	4	5
97	4x52	4x56	m1_off	2.98	0	No	No	No	No	5	8
98	5x53	5x57	m1_off	2.98	0	No	No	No	No	7	8
99	5x49	5x52	m1_off	2.95	0	No	No	No	No	7	5
100	6x46	6x47	m1_off	2.95	0	No	No	Yes	No	5	8
101	8x53	8x57	m1_off	2.95	0	No	No	No	No	8	8
102	5x68	I2x50	m1_off	2.88	0	Yes	No	No	No	8	8
103	3x21	E1x50	m1_off	2.81	0	No	No	Yes	Yes	7	9
104	4x48	4x51	m1_off	2.77	0	No	No	No	No	4	4
105	6x42	6x46	m1_off	2.77	0	No	No	No	No	7	5
106	2x66	E1x49	m1_off	2.63	0	No	No	No	No	6	5
107	5x68	6x27	m1_off	2.43	0	Yes	No	No	No	8	5
108	8x55	8x56	m1_off	2.43	0	No	No	No	No	6	6
109	8x56	CT.R436	m1_off	2.43	0	No	No	No	No	6	4
110	I2x54	I2x57	m1_off	2.13	0	No	No	Yes	Yes	7	8
111	5x44	Lig	m1_off	2.01	0	No	No	Yes	Yes	7	0
112	1x47	2x54	m1_off	1.84	0	No	No	No	No	7	8
113	6x39	7x52	m1_off	1.81	0	No	No	No	No	8	8
114	3x30	4x58	m1_off	1.79	0	No	No	No	No	8	6
115	5x37	6x58	m1_off	1.78	0	No	No	No	No	5	5
116	1x40	1x44	m1_off	1.71	0	No	No	No	No	5	5
117	5x51	5x55	m1_off	1.71	0	No	No	No	No	7	5
118	6x57	E3.C394	m1_off	1.71	0	No	No	No	No	6	8
119	7x36	7x37	m1_off	1.71	0	No	No	No	No	5	6
120	2x38	4x42	m1_off	1.7	0	No	Yes	No	No	7	8
121	5x37	5x38	m1_off	1.69	0	No	No	No	No	5	5
122	E2.G176	E2.Q177	m1_off	1.64	0	No	No	No	No	2	4
123	1x38	1x39	m1_off	1.57	0	No	No	Yes	Yes	4	6
124	7x30	7x31	m1_off	1.57	0	No	No	No	No	6	3
125	6x53	6x57	m1_off	1.54	0	No	No	No	No	7	6
126	1x32	2x66	m1_off	1.52	0	No	No	No	No	4	6
127	2x62	2x66	m1_off	1.51	0	No	No	No	No	7	6
128	6x29	6x32	m1_off	1.44	0	No	No	No	No	7	8
129	6x27	6x31	m1_off	1.41	0	No	No	No	No	5	7
130	8x47	8x48	m1_off	1.4	0	No	No	No	No	9	5
131	6x31	6x35	m1_off	1.24	0	No	No	No	No	7	7
132	1x39	2x61	Shared	10.99	7.85	Yes	Yes	No	No	6	8
133	1x39	7x39	Shared	8.49	7.28	Yes	Yes	No	Yes	6	8
134	1x43	2x58	Shared	8.94	7.45	No	No	No	No	7	9
135	1x46	2x54	Shared	3.64	5.46	No	No	No	No	8	8
136	1x46	7x47	Shared	9.42	6.28	No	No	No	No	8	8
137	1x50	2x50	Shared	6.73	6.73	Yes	Yes	Yes	Yes	9	9
138	1x50	7x50	Shared	13.03	8.15	Yes	Yes	No	No	9	9
139	1x52	8x54	Shared	13.4	7.31	No	No	Yes	No	8	9
140	1x53	8x54	Shared	3.93	2.62	No	No	Yes	No	9	9
141	1x54	2x44	Shared	4.15	2.77	No	No	No	No	7	7
142	1x56	8x50	Shared	3.96	6.61	No	No	Yes	Yes	9	9
143	1x57	I1x51	Shared	6.2	4.96	No	No	No	No	8	7
144	1x57	2x41	Shared	4.13	5.16	No	No	No	No	8	7
145	1x57	2x44	Shared	13.4	9.74	No	No	No	No	8	7
146	1x59	CT.W437	Shared	14.71	8.58	No	No	No	Yes	7	3
147	1x60	I1x49	Shared	6.57	10.52	Yes	Yes	No	No	8	7
148	1x60	I1x50	Shared	6.87	9.61	Yes	Yes	No	No	8	9
149	1x60	8x53	Shared	8.77	5.85	Yes	Yes	No	No	8	8
150	1x60	CT.W437	Shared	7.91	9.04	Yes	Yes	No	Yes	8	3
151	CT.K439	I1x48	Shared	6.01	7.51	No	No	No	No	5	7
152	8x50	I1x50	Shared	13.4	6.09	Yes	Yes	No	No	9	9
153	2x37	2x40	Shared	8.77	2.92	No	No	No	No	8	9
154	2x38	I2x57	Shared	9.15	6.54	No	Yes	Yes	Yes	7	8
155	2x38	4x39	Shared	3.53	3.53	No	Yes	No	No	7	5
156	2x39	I2x57	Shared	7.23	9.64	No	No	Yes	Yes	8	8
157	2x40	8x50	Shared	7.25	12.08	No	No	Yes	Yes	9	9
158	2x42	3x45	Shared	7.31	6.09	Yes	No	No	No	8	7
159	2x42	3x49	Shared	7.17	13.14	Yes	No	No	No	8	9
160	2x42	4x46	Shared	6.28	6.28	Yes	No	No	No	8	9
161	2x45	3x42	Shared	7.45	4.47	No	No	No	No	9	8
162	2x50	7x46	Shared	8.83	7.36	Yes	Yes	No	No	9	9
163	2x50	7x49	Shared	8.08	8.08	Yes	Yes	No	No	9	9
164	2x52	3x31	Shared	4.28	4.28	No	No	No	No	8	6
165	2x53	7x46	Shared	7.74	9.29	Yes	No	No	No	8	9
166	2x55	2x551	Shared	14.27	3.89	No	No	No	No	5	6
167	2x551	3x31	Shared	4.87	3.65	No	No	No	No	6	6
168	2x56	3x32	Shared	11.78	10.31	No	No	Yes	No	8	9
169	2x56	7x42	Shared	3.82	3.82	No	No	Yes	Yes	8	8
170	2x57	7x42	Shared	13.17	11.97	Yes	No	Yes	Yes	8	8
171	2x59	3x28	Shared	10.25	7.97	No	No	Yes	Yes	7	7
172	2x60	2x64	Shared	3.52	9.38	Yes	Yes	No	No	7	7
173	2x60	3x28	Shared	6.75	3.86	Yes	Yes	Yes	Yes	7	7
174	2x60	7x38	Shared	19.86	11.91	Yes	Yes	Yes	Yes	7	7
175	2x60	7x42	Shared	7.94	6.95	Yes	Yes	Yes	Yes	7	8
176	2x63	E1x50	Shared	7.72	8.68	No	Yes	Yes	Yes	7	9
177	2x63	E2.Q177	Shared	6.76	3.38	No	Yes	No	No	7	4
178	2x64	7x35	Shared	6.63	9.28	No	No	No	No	7	6
179	E1x50	E1x52	Shared	5.69	4.56	Yes	Yes	No	No	9	7
180	3x25	E1x50	Shared	7.84	6.53	No	No	Yes	Yes	9	9
181	3x28	E1x50	Shared	9.37	4.69	Yes	Yes	Yes	Yes	7	9
182	E1x50	E2x50	Shared	7.84	11.75	Yes	Yes	No	No	9	9
183	3x22	E2.R171	Shared	10.35	9.06	No	No	Yes	Yes	4	7
184	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
185	3x26	4x65	Shared	6.53	6.53	No	No	No	No	7	7
186	3x26	E2.R171	Shared	8.34	10.72	No	No	Yes	Yes	7	7
187	3x28	3x29	Shared	7.97	7.97	Yes	Yes	No	No	7	7
188	3x30	4x62	Shared	4.73	3.15	No	No	No	No	8	6
189	3x32	7x42	Shared	10.34	9.2	Yes	No	Yes	Yes	9	8
190	3x32	Lig	Shared	4.33	9.68	Yes	No	Yes	Yes	9	0
191	3x33	4x57	Shared	15.43	16.4	Yes	Yes	Yes	Yes	8	8
192	3x33	4x61	Shared	3.63	3.63	Yes	Yes	Yes	Yes	8	7
193	3x33	E2x52	Shared	8.46	7.25	Yes	Yes	Yes	Yes	8	7
194	3x33	7x38	Shared	4.96	6.95	Yes	Yes	Yes	Yes	8	7
195	3x33	Lig	Shared	20.96	13.38	Yes	Yes	Yes	Yes	8	0
196	3x34	4x54	Shared	5.24	2.62	No	No	No	No	8	6
197	3x36	6x48	Shared	6.18	3.71	No	No	Yes	Yes	8	8
198	3x36	Lig	Shared	9.59	11.78	No	No	Yes	Yes	8	0
199	3x37	4x53	Shared	5.78	5.78	Yes	Yes	No	No	8	8
200	3x37	4x57	Shared	8.76	8.76	Yes	Yes	Yes	Yes	8	8
201	3x37	5x461	Shared	4.55	4.55	Yes	Yes	No	No	8	8
202	3x37	Lig	Shared	5.1	10.44	Yes	Yes	Yes	Yes	8	0
203	3x38	4x50	Shared	9.08	7.78	No	No	Yes	No	8	9
204	3x40	6x48	Shared	3.68	4.9	No	No	Yes	Yes	9	8
205	3x42	4x50	Shared	4.52	6.78	No	No	Yes	No	8	9
206	3x43	5x54	Shared	5.65	4.24	No	Yes	No	No	8	9
207	3x43	6x44	Shared	8.53	4.87	No	Yes	Yes	Yes	8	9
208	3x44	5x50	Shared	4.93	3.28	No	No	No	No	7	9
209	3x47	5x54	Shared	6.13	4.6	No	No	No	No	9	9
210	3x48	5x57	Shared	7.31	8.53	No	No	No	No	7	8
211	3x49	I2x53	Shared	8.05	9.2	No	No	Yes	Yes	9	9
212	3x49	I2x57	Shared	13.1	9.53	No	No	Yes	Yes	9	8
213	3x51	3x55	Shared	16.23	16.23	Yes	No	No	No	8	8
214	3x51	5x57	Shared	3.52	15.24	Yes	No	No	No	8	8
215	3x52	I2x53	Shared	11.35	11.35	Yes	No	Yes	Yes	7	9
216	3x53	I2x53	Shared	3.82	2.54	No	No	Yes	Yes	9	9
217	I2x53	I2x57	Shared	8.23	19.55	Yes	Yes	Yes	Yes	9	8
218	4x38	4x39	Shared	3.5	3.5	No	No	No	No	8	5
219	4x38	4x40	Shared	9.06	1.29	No	No	No	No	8	6
220	4x54	4x58	Shared	8.32	4.16	No	No	No	No	6	6
221	4x57	4x61	Shared	3.52	3.52	Yes	Yes	Yes	Yes	8	7
222	4x57	Lig	Shared	8	7.31	Yes	Yes	Yes	Yes	8	0
223	4x60	E2.F182	Shared	4.16	2.77	No	No	Yes	Yes	7	6
224	4x61	E2x52	Shared	5.89	5.89	Yes	Yes	Yes	Yes	7	7
225	4x62	4x63	Shared	6.09	3.65	No	No	No	No	6	6
226	4x64	4x68	Shared	8.58	6.13	No	Yes	No	Yes	7	4
227	4x64	E2.Q181	Shared	5.48	12.05	No	Yes	No	No	7	8
228	4x64	E2.F182	Shared	10.02	11.02	No	Yes	Yes	Yes	7	6
229	4x65	4x66	Shared	13.53	6.76	No	No	No	No	7	5
230	4x65	E2.R171	Shared	10.51	7.01	No	No	Yes	Yes	7	7
231	E2.R171	E2.V173	Shared	7.85	6.54	Yes	Yes	No	No	7	4
232	E2.Q181	E2.T172	Shared	9.92	4.25	No	No	No	No	8	4
233	E2.V173	E2x51	Shared	16.4	10.09	No	No	No	No	4	4
234	E2.L174	E2.Q177	Shared	3.99	2.66	No	No	No	No	3	4
235	E2.F182	E2x52	Shared	5.02	5.02	Yes	Yes	Yes	Yes	6	7
236	E2.L183	E2x52	Shared	7.14	7.14	Yes	No	Yes	Yes	7	7
237	5x36	E2.S184	Shared	5.78	2.89	No	No	No	No	7	6
238	5x41	5x45	Shared	7.46	4.98	Yes	No	No	No	7	6
239	5x41	6x56	Shared	7.31	4.87	Yes	No	No	No	7	7
240	5x45	5x48	Shared	4.79	5.99	No	No	No	Yes	6	7
241	5x47	5x51	Shared	7.87	7.87	Yes	Yes	No	No	9	7
242	5x47	6x48	Shared	7.02	6.01	Yes	Yes	Yes	Yes	9	8
243	5x47	6x52	Shared	22.96	25.37	Yes	Yes	No	No	9	8
244	5x48	6x52	Shared	5.81	3.49	No	Yes	No	No	7	8
245	5x54	6x44	Shared	3.73	7.46	No	No	Yes	Yes	9	9
246	5x59	5x63	Shared	10	7	No	No	No	No	4	5
247	5x64	5x67	Shared	5.26	2.63	No	No	No	No	7	5
248	6x40	7x52	Shared	4.91	1.64	No	Yes	No	No	8	8
249	6x43	7x48	Shared	4.87	1.62	No	No	No	No	7	6
250	6x44	6x48	Shared	17.04	8.02	Yes	Yes	Yes	Yes	9	8
251	6x47	6x48	Shared	3.64	3.64	Yes	No	Yes	Yes	8	8
252	6x47	7x45	Shared	5.85	7.31	Yes	No	No	No	8	9
253	6x48	7x41	Shared	11.75	16.98	Yes	Yes	No	No	8	8
254	6x48	7x45	Shared	7.91	10.17	Yes	Yes	No	No	8	9
255	6x48	Lig	Shared	10.91	16.25	Yes	Yes	Yes	Yes	8	0
256	6x49	6x50	Shared	3.5	5.25	No	Yes	No	No	7	9
257	6x50	7x40	Shared	4.93	4.93	No	No	No	No	9	8
258	6x51	7x38	Shared	7.94	3.97	No	Yes	Yes	Yes	8	7
259	6x51	Lig	Shared	14.22	8.36	No	Yes	Yes	Yes	8	0
260	6x54	E3.V395	Shared	6.09	3.04	No	No	Yes	No	6	6
261	6x54	7x34	Shared	8.14	4.65	No	No	Yes	Yes	6	7
262	6x58	7x34	Shared	4.94	2.47	No	No	Yes	Yes	5	7
263	6x59	6x60	Shared	9.08	3.89	No	No	No	No	8	5
264	6x61	E3.C394	Shared	7.28	7.28	No	No	No	No	6	8
265	7x30	E3.V395	Shared	3.53	3.53	No	No	Yes	No	6	6
266	7x38	Lig	Shared	16.47	10.03	Yes	Yes	Yes	Yes	7	0
267	7x41	Lig	Shared	6.08	4.53	No	No	Yes	Yes	8	0
268	7x42	Lig	Shared	4.49	5.85	Yes	Yes	Yes	Yes	8	0
269	8x47	8x50	Shared	7.25	8.46	No	No	Yes	Yes	9	9
270	8x48	8x52	Shared	11.06	2.77	No	No	No	No	5	6
271	3x38	4x53	Shared	3.42	3.42	No	No	No	No	8	8
272	8x56	CT.W437	Shared	3.42	5.69	No	No	No	Yes	6	3
273	1x53	2x47	Shared	3.39	3.39	No	No	No	No	9	9
274	2x52	3x35	Shared	3.25	4.87	No	No	No	No	8	7
275	2x53	3x35	Shared	3.25	3.25	Yes	No	No	No	8	7
276	3x30	4x61	Shared	3.25	1.62	No	No	Yes	Yes	8	7
277	3x41	4x49	Shared	3.22	1.61	No	No	No	No	7	8
278	1x54	2x48	Shared	3.17	1.59	No	No	No	No	7	6
279	6x45	6x49	Shared	3.04	4.56	No	No	No	Yes	7	7
280	6x49	6x53	Shared	3.04	1.52	No	Yes	No	No	7	7
281	3x44	5x53	Shared	2.98	2.98	No	No	No	No	7	7
282	1x48	1x52	Shared	2.95	2.95	No	Yes	No	No	5	8
283	2x61	2x65	Shared	2.95	7.37	No	No	No	No	8	6
284	E1x49	E1x51	Shared	2.93	2.93	No	No	No	No	5	4
285	3x23	3x27	Shared	2.77	2.77	No	No	No	No	4	6
286	1x50	2x51	Shared	2.75	2.75	Yes	Yes	No	No	9	8
287	3x56	I2x52	Shared	2.64	6.59	Yes	No	No	No	7	7
288	2x49	4x50	Shared	2.59	2.59	No	No	Yes	No	9	9
289	3x24	E1x50	Shared	2.59	2.59	No	No	Yes	Yes	6	9
290	3x50	5x58	Shared	2.06	6.17	Yes	No	No	Yes	9	9
291	3x51	5x60	Shared	2.06	7.2	Yes	No	No	No	8	7
292	4x58	4x59	Shared	1.87	1.87	No	No	No	No	6	8
293	1x40	1x43	Shared	1.86	3.71	No	No	No	No	5	7
294	4x68	4x69	Shared	1.84	1.84	No	Yes	No	No	4	4
295	1x36	1x39	Shared	1.82	1.82	No	No	Yes	Yes	5	6
296	6x36	7x56	Shared	1.69	1.69	No	No	No	No	8	8
297	1x45	7x47	Shared	1.68	1.68	No	No	No	No	5	8
298	5x49	5x50	Shared	1.64	3.28	No	No	No	No	7	9
299	4x68	E2.E170	Shared	1.43	8.56	No	Yes	No	No	4	4
300	5x65	5x66	Shared	1.41	4.23	No	No	No	No	8	7
301	3x27	4x62	Shared	1.38	1.38	No	No	No	No	6	6
302	4x54	4x55	Shared	1.31	1.31	No	No	No	No	6	5
303	8x48	8x51	Shared	1.24	1.24	No	No	No	No	5	9
304	1x29	1x31	m1_on	0	7.9	No	No	No	No	2	6
305	1x30	1x31	m1_on	0	12.05	No	No	No	No	4	6
306	1x42	7x39	m1_on	0	3.42	No	No	No	Yes	7	8
307	1x46	1x50	m1_on	0	4.39	No	No	Yes	Yes	8	9
308	1x52	8x57	m1_on	0	4.15	No	No	No	No	8	8
309	I1x48	I1x49	m1_on	0	4.23	No	No	No	No	7	7
310	CT.W442	I1x49	m1_on	0	4.36	No	No	No	No	0	7
311	2x38	2x41	m1_on	0	3.79	No	Yes	No	No	7	7
312	2x40	2x43	m1_on	0	5.49	No	No	No	No	9	9
313	2x45	4x46	m1_on	0	7.74	No	No	No	No	9	9
314	2x46	3x43	m1_on	0	5.54	No	No	No	Yes	9	8
315	2x46	7x49	m1_on	0	10.98	No	No	No	No	9	9
316	2x46	7x53	m1_on	0	3.52	No	No	No	Yes	9	9
317	2x52	2x551	m1_on	0	3.77	No	No	No	No	8	6
318	2x53	3x36	m1_on	0	4.64	Yes	No	No	No	8	8
319	2x57	7x39	m1_on	0	8.14	Yes	No	No	Yes	8	8
320	2x60	7x39	m1_on	0	4.82	Yes	Yes	No	Yes	7	8
321	2x63	2x64	m1_on	0	3.52	No	Yes	No	No	7	7
322	2x63	E2x50	m1_on	0	4.03	No	Yes	No	No	7	9
323	3x25	3x26	m1_on	0	4.67	No	No	No	No	9	7
324	3x33	6x51	m1_on	0	7.94	Yes	Yes	No	Yes	8	8
325	3x34	4x53	m1_on	0	4.85	No	No	No	No	8	8
326	3x37	3x41	m1_on	0	5.44	Yes	Yes	No	No	8	7
327	3x40	6x44	m1_on	0	3.93	No	No	Yes	Yes	9	9
328	3x40	Lig	m1_on	0	5.31	No	No	Yes	Yes	9	0
329	3x43	7x49	m1_on	0	5.49	No	Yes	No	No	8	9
330	3x43	7x53	m1_on	0	4.69	No	Yes	No	Yes	8	9
331	3x44	3x48	m1_on	0	3.65	No	No	No	No	7	7
332	3x46	3x50	m1_on	0	5.01	No	No	Yes	No	9	9
333	3x46	7x53	m1_on	0	3.63	No	No	No	Yes	9	9
334	3x47	5x57	m1_on	0	4.5	No	No	No	No	9	8
335	3x47	5x58	m1_on	0	3.82	No	No	No	Yes	9	9
336	3x50	7x53	m1_on	0	9.26	Yes	No	No	Yes	9	9
337	I2x52	I2x56	m1_on	0	6.12	No	No	No	No	7	6
338	4x38	4x41	m1_on	0	6.47	No	No	No	No	8	8
339	4x40	4x44	m1_on	0	7.29	No	No	No	No	6	2
340	4x57	5x43	m1_on	0	4.85	Yes	Yes	No	No	8	8
341	4x64	5x36	m1_on	0	8.76	No	Yes	No	No	7	7
342	E2.E170	E2.T172	m1_on	0	11.29	No	No	No	No	4	4
343	E2.E170	E2.Q181	m1_on	0	7.65	No	No	No	No	4	8
344	5x39	E2.F182	m1_on	0	5.02	No	No	Yes	Yes	8	6
345	5x40	6x59	m1_on	0	4.71	No	No	No	No	7	8
346	5x42	5x45	m1_on	0	3.49	No	No	No	No	6	6
347	5x47	5x48	m1_on	0	11.35	Yes	Yes	No	Yes	9	7
348	5x47	6x49	m1_on	0	3.89	Yes	Yes	No	Yes	9	7
349	5x47	Lig	m1_on	0	5.21	Yes	Yes	Yes	Yes	9	0
350	5x48	6x56	m1_on	0	3.52	No	Yes	No	No	7	7
351	5x51	6x44	m1_on	0	3.93	No	No	Yes	Yes	7	9
352	5x55	6x41	m1_on	0	6.35	No	No	No	No	5	7
353	5x58	6x37	m1_on	0	7.03	No	Yes	No	No	9	9
354	5x58	6x40	m1_on	0	7.25	No	Yes	No	Yes	9	8
355	5x58	6x41	m1_on	0	10.55	No	Yes	No	No	9	7
356	5x58	7x53	m1_on	0	4.96	No	Yes	No	Yes	9	9
357	5x62	5x66	m1_on	0	13.47	No	Yes	No	No	7	7
358	5x62	6x34	m1_on	0	6.67	No	Yes	No	No	7	8
359	5x62	6x37	m1_on	0	3.52	No	Yes	No	No	7	9
360	5x66	6x31	m1_on	0	10.8	No	No	No	No	7	7
361	5x68	5x72	m1_on	0	4.86	Yes	No	No	No	8	0
362	6x40	7x53	m1_on	0	6.04	No	Yes	No	Yes	8	9
363	6x51	6x52	m1_on	0	8.14	No	Yes	No	No	8	8
364	6x51	6x55	m1_on	0	6.31	No	Yes	No	No	8	8
365	7x31	7x34	m1_on	0	4.36	No	No	Yes	Yes	3	7
366	7x39	7x42	m1_on	0	18.33	No	Yes	Yes	Yes	8	8
367	7x55	8x54	m1_on	0	4.87	No	No	Yes	No	7	9
368	8x52	8x55	m1_on	0	11.91	No	No	No	No	6	6
369	8x53	CT.W437	m1_on	0	3.64	No	No	No	Yes	8	3
370	8x58	CT.R436	m1_on	0	6.07	No	No	No	No	8	4
371	CT.W437	CT.W442	m1_on	0	3.75	No	Yes	No	No	3	0
372	CT.D438	CT.R440	m1_on	0	3.57	No	No	No	No	4	0
373	CT.R441	CT.R443	m1_on	0	6.4	No	No	No	No	0	0
374	2x37	2x38	m1_on	0	3.17	No	No	No	Yes	8	7
375	6x47	7x43	m1_on	0	3.17	Yes	No	No	No	8	7
376	1x54	2x47	m1_on	0	3.15	No	No	No	No	7	9
377	8x47	8x49	m1_on	0	3.13	No	No	No	No	9	7
378	3x41	4x52	m1_on	0	3.04	No	No	No	No	7	5
379	4x48	4x52	m1_on	0	2.98	No	No	No	No	4	5
380	1x44	1x48	m1_on	0	2.95	No	No	No	Yes	5	5
381	2x50	3x39	m1_on	0	2.94	Yes	Yes	No	No	9	9
382	7x34	7x38	m1_on	0	2.89	Yes	Yes	Yes	Yes	7	7
383	3x54	5x64	m1_on	0	2.85	No	No	No	No	8	7
384	5x61	6x37	m1_on	0	2.85	No	No	No	No	9	9
385	6x54	7x33	m1_on	0	2.83	No	No	No	No	6	5
386	7x51	7x55	m1_on	0	2.83	No	No	No	No	6	7
387	7x32	7x35	m1_on	0	2.82	No	No	No	No	4	6
388	4x42	I2x57	m1_on	0	2.77	No	No	Yes	Yes	8	8
389	5x62	6x33	m1_on	0	2.67	No	Yes	No	No	7	9
390	3x37	4x56	m1_on	0	2.66	Yes	Yes	No	No	8	8
391	5x40	E2.F182	m1_on	0	2.59	No	No	Yes	Yes	7	6
392	5x56	5x60	m1_on	0	2.59	No	No	No	No	5	7
393	3x21	3x24	m1_on	0	1.95	No	No	No	No	7	6
394	E2.A175	E2.G176	m1_on	0	1.95	No	No	No	No	3	2
395	1x39	1x40	m1_on	0	1.82	Yes	Yes	No	No	6	5
396	1x48	1x49	m1_on	0	1.82	No	Yes	No	No	5	9
397	1x35	1x36	m1_on	0	1.76	No	No	No	No	7	5
398	5x37	6x59	m1_on	0	1.75	No	No	No	No	5	8
399	1x53	7x54	m1_on	0	1.7	No	No	No	No	9	8
400	CT.I445	CT.P446	m1_on	0	1.69	No	No	No	No	0	0
401	7x48	7x52	m1_on	0	1.64	No	No	No	No	6	8
402	3x53	3x54	m1_on	0	1.62	No	No	No	No	9	8
403	1x47	1x48	m1_on	0	1.59	No	No	No	Yes	7	5
404	E1x49	E2.G176	m1_on	0	1.59	No	No	No	No	5	2
405	5x52	5x56	m1_on	0	1.57	No	No	No	No	5	5
406	1x55	1x59	m1_on	0	1.54	No	No	No	No	6	7
407	6x36	6x40	m1_on	0	1.52	No	No	No	Yes	8	8
408	1x47	1x51	m1_on	0	1.49	No	No	No	No	7	5
409	4x67	4x68	m1_on	0	1.49	No	No	No	Yes	4	4
410	2x59	2x62	m1_on	0	1.47	No	No	No	No	7	7
411	7x32	7x36	m1_on	0	1.47	No	No	No	No	4	5
412	3x56	I2x50	m1_on	0	1.44	Yes	No	No	No	7	8
413	1x31	1x32	m1_on	0	1.43	No	No	No	No	6	4
414	1x37	1x41	m1_on	0	1.43	No	No	No	No	4	5
415	3x45	4x45	m1_on	0	1.41	No	No	No	No	7	7
416	4x40	4x43	m1_on	0	1.38	No	No	No	No	6	5
417	E3.D393	E3.K392	m1_on	0	1.38	No	No	No	No	4	4
418	5x44	5x48	m1_on	0	1.33	No	No	No	Yes	7	7
419	5x67	5x71	m1_on	0	1.31	No	No	No	No	5	0
420	CT.D438	CT.R441	m1_on	0	1.19	No	No	No	No	4	0

Orange: nodes, hubs and links specific of m1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	m1_off Avg Int. Strength	m1_on Avg Int. Strength	m1_off Num Of Links	m1_on Num Of Links	ConSurf
1	NT.K20	m1_off	4.525	0	4	0	5
2	2x42	m1_off	6.445	8.50333	4	3	8
3	2x53	m1_off	5.42	5.72667	5	3	8
4	2x57	m1_off	6.25	10.055	4	2	8
5	3x32	m1_off	7.7625	9.73	4	3	9
6	3x50	m1_off	5.585	6.81333	4	3	9
7	3x51	m1_off	6.16	12.89	6	3	8
8	3x52	m1_off	7.3275	11.35	4	1	7
9	3x56	m1_off	5.88	4.015	4	2	7
10	4x50	m1_off	5.5925	5.71667	4	3	9
11	E2.L183	m1_off	6.56	7.14	4	1	7
12	5x41	m1_off	5.9725	4.925	4	2	7
13	5x68	m1_off	5.7	4.86	5	1	8
14	6x47	m1_off	4.215	4.70667	4	3	8
15	E3.V395	m1_off	5.975	3.285	4	2	6
16	8x54	m1_off	6.6925	4.93333	4	3	9
17	1x39	Shared	5.7175	4.6925	4	4	6
18	1x50	Shared	6.8	5.505	4	4	9
19	1x60	Shared	7.53	8.755	4	4	8
20	2x50	Shared	6.9275	6.2775	4	4	9
21	2x60	Shared	9.5175	7.384	4	5	7
22	E1x50	Shared	6.26571	6.46667	7	6	9
23	3x28	Shared	7.652	6.1225	5	4	7
24	3x33	Shared	10.688	9.25833	5	6	8
25	3x37	Shared	5.698	6.27167	5	6	8
26	I2x53	Shared	7.006	10.66	5	4	9
27	I2x57	Shared	7.968	9.606	5	5	8
28	4x57	Shared	7.826	8.168	5	5	8
29	4x61	Shared	4.0725	3.665	4	4	7
30	E2.R171	Shared	9.2625	8.3325	4	4	7
31	E2x52	Shared	6.158	6.325	5	4	7
32	E2.F182	Shared	6.6275	5.284	4	5	6
33	5x47	Shared	10.8025	9.95	4	6	9
34	6x44	Shared	7.656	5.642	5	5	9
35	6x48	Shared	8.51625	8.71	8	8	8
36	7x34	Shared	7.41	3.5925	4	4	7
37	7x38	Shared	10.13	7.15	6	5	7
38	7x42	Shared	7.36429	9.35333	7	6	8
39	8x50	Shared	7.965	8.31	4	4	9
40	Lig	Shared	8.67214	9.01083	14	12	0
41	1x48	m1_on	2.95	2.3275	1	4	5
42	2x38	m1_on	4.79333	4.2575	3	4	7
43	2x63	m1_on	7.24	4.9025	2	4	7
44	3x43	m1_on	6.57333	4.966	3	5	8
45	4x64	m1_on	8.02667	9.49	3	4	7
46	4x68	m1_on	3.95	4.505	3	4	4
47	5x48	m1_on	5.3	5.136	2	5	7
48	5x58	m1_on	3.575	6.63	2	6	9
49	5x62	m1_on	15.43	6.5825	1	4	7
50	6x40	m1_on	5.995	4.1125	2	4	8
51	6x49	m1_on	3.19333	3.805	3	4	7
52	6x51	m1_on	9.63667	6.944	3	5	8
53	7x39	m1_on	8.49	8.398	1	5	8
54	7x53	m1_on	10.8	5.35	3	6	9
55	CT.W437	m1_on	8.68	6.14	3	5	3

Orange: nodes, hubs and links specific of m1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	m1_off Recurrence	m1_on Recurrence	m1_off Hub1?	m1_on Hub1?	m1_off Hub2?	m1_on Hub2?	ConSurf1	ConSurf2
1	2x64	NT.K20	m1_off	27.7918	0	No	No	Yes	No	7	5
2	1x32	NT.K20	m1_off	21.57	0	No	No	Yes	No	4	5
3	1x32	2x65	m1_off	13.3712	0	No	No	No	No	4	6
4	2x61	2x65	m1_off	10.0595	1.59941	No	No	No	No	8	6
5	2x57	7x42	m1_off	15.5309	1.44685	Yes	No	Yes	Yes	8	8
6	2x53	7x42	m1_off	57.4692	0	Yes	No	Yes	Yes	8	8
7	1x50	2x47	m1_off	39.2995	0	Yes	Yes	No	No	9	9
8	1x56	8x54	m1_off	27.1189	0	No	No	Yes	No	9	9
9	1x56	8x50	m1_off	26.0446	1.75197	No	No	Yes	Yes	9	9
10	3x37	3x40	m1_off	53.709	0	Yes	Yes	No	No	8	9
11	3x40	5x50	m1_off	100	0	No	No	No	No	9	9
12	3x44	5x50	m1_off	96.669	4.61122	No	No	No	No	7	9
13	3x44	5x53	m1_off	95.5531	2.30807	No	No	No	No	7	7
14	5x53	5x57	m1_off	94.4372	0	No	No	No	No	7	8
15	3x48	3x52	m1_off	38.8398	0	No	No	Yes	No	7	7
16	3x52	I2x53	m1_off	78.3525	1.75197	Yes	No	Yes	Yes	7	9
17	I2x53	I2x57	m1_off	47.6727	1.63386	Yes	Yes	Yes	Yes	9	8
18	2x41	4x39	m1_off	25.776	0	No	No	No	No	7	5
19	3x40	6x48	m1_off	48.7055	0.127953	No	No	Yes	Yes	9	8
20	3x51	3x52	m1_off	42.0352	0	Yes	No	Yes	No	8	7
21	2x63	E1x50	m1_off	18.0867	0.46752	No	Yes	Yes	Yes	7	9
22	2x63	E2.Q177	m1_off	16.4696	5.11319	No	Yes	No	No	7	4
23	E2.L174	E2.Q177	m1_off	13.2189	2.55906	No	No	No	No	3	4
24	E2.L174	E2x51	m1_off	11.5852	0	No	No	No	No	3	4
25	3x30	4x58	m1_off	11.9147	0	No	No	No	No	8	6
26	3x43	6x41	m1_off	14.4206	0	No	Yes	No	No	8	7
27	6x37	6x41	m1_off	13.7782	0	No	No	No	No	9	7
28	3x50	6x37	m1_off	13.1054	0	Yes	No	No	No	9	9
29	3x50	5x61	m1_off	10.7102	0	Yes	No	No	No	9	9
30	6x51	7x34	m1_off	18.61	0	No	Yes	Yes	Yes	8	7
31	6x52	Lig	m1_off	11.9673	0	No	No	Yes	Yes	8	0
32	5x48	6x52	m1_off	12.3134	2.16535	No	Yes	No	No	7	8
33	5x45	5x48	m1_off	10.7933	6.14665	No	No	No	Yes	6	7
34	6x47	6x48	m1_off	11.1145	2.78051	Yes	No	Yes	Yes	8	8
35	6x51	Lig	m1_off	14.0966	2.74606	No	Yes	Yes	Yes	8	0
36	2x60	2x64	Shared	30.9317	19.311	Yes	Yes	No	No	7	7
37	2x60	7x42	Shared	32.1113	27.8691	Yes	Yes	Yes	Yes	7	8
38	2x53	7x46	Shared	50.9622	12.7165	Yes	No	No	No	8	9
39	2x50	7x46	Shared	50.0208	11.875	Yes	Yes	No	No	9	9
40	1x50	2x50	Shared	43.2757	11.2598	Yes	Yes	Yes	Yes	9	9
41	1x53	2x47	Shared	38.2916	20.4282	No	No	No	No	9	9
42	1x53	8x54	Shared	32.1971	17.1211	No	No	Yes	No	9	9
43	8x50	I1x50	Shared	16.2398	20.2067	Yes	Yes	No	No	9	9
44	1x60	I1x50	Shared	15.1876	18.5581	Yes	Yes	No	No	8	9
45	2x60	7x38	Shared	27.6866	35.0984	Yes	Yes	Yes	Yes	7	7
46	7x38	Lig	Shared	24.5383	35.8809	Yes	Yes	Yes	Yes	7	0
47	3x37	Lig	Shared	48.0881	89.2175	Yes	Yes	Yes	Yes	8	0
48	3x48	5x57	Shared	40.1052	11.4616	No	No	No	No	7	8
49	2x38	I2x57	Shared	39.7425	69.0896	No	Yes	Yes	Yes	7	8
50	2x38	4x39	Shared	34.3458	10.3888	No	Yes	No	No	7	5
51	1x57	2x41	Shared	22.9074	30.1132	No	No	No	No	8	7
52	1x57	2x44	Shared	11.6129	26.9242	No	No	No	No	8	7
53	7x42	Lig	Shared	79.7951	43.2431	Yes	Yes	Yes	Yes	8	0
54	6x48	Lig	Shared	65.9255	48.6171	Yes	Yes	Yes	Yes	8	0
55	3x51	5x57	Shared	53.3739	11.4616	Yes	No	No	No	8	8
56	3x49	I2x53	Shared	17.0899	10.3642	No	No	Yes	Yes	9	9
57	2x42	3x49	Shared	14.4815	82.9478	Yes	No	No	No	8	9
58	2x60	3x28	Shared	30.9234	40.9547	Yes	Yes	Yes	Yes	7	7
59	3x28	E1x50	Shared	25.848	31.6585	Yes	Yes	Yes	Yes	7	9
60	3x33	E2x52	Shared	13.5899	33.75	Yes	Yes	Yes	Yes	8	7
61	3x30	4x61	Shared	19.1666	11.1417	No	No	Yes	Yes	8	7
62	6x44	6x48	Shared	14.1132	51.8701	Yes	Yes	Yes	Yes	9	8
63	3x43	6x44	Shared	14.7307	49.4193	No	Yes	Yes	Yes	8	9
64	E2.F182	E2x52	Shared	14.3292	37.6427	Yes	Yes	Yes	Yes	6	7
65	4x64	E2.F182	Shared	15.8798	22.4852	No	Yes	Yes	Yes	7	6
66	3x33	Lig	Shared	14.4344	26.6437	Yes	Yes	Yes	Yes	8	0
67	4x57	4x61	Shared	11.9396	14.2077	Yes	Yes	Yes	Yes	8	7
68	1x39	7x39	m1_on	1.66967	12.4606	Yes	Yes	No	Yes	6	8
69	7x39	7x42	m1_on	0	12.3819	No	Yes	Yes	Yes	8	8
70	3x36	Lig	m1_on	0.67562	17.3081	No	No	Yes	Yes	8	0
71	2x53	3x36	m1_on	0	19.3307	Yes	No	No	No	8	8
72	3x37	4x53	m1_on	8.56985	100	Yes	Yes	No	No	8	8
73	3x38	4x53	m1_on	5.39665	93.4449	No	No	No	No	8	8
74	3x38	4x50	m1_on	4.32784	92.3179	No	No	Yes	No	8	9
75	3x42	4x50	m1_on	1.08542	90.0344	No	No	Yes	No	8	9
76	2x45	3x42	m1_on	0	88.878	No	No	No	No	9	8
77	2x45	4x46	m1_on	0	87.7116	No	No	No	No	9	9
78	2x42	4x46	m1_on	5.81753	86.5354	Yes	No	No	No	8	9
79	3x49	I2x57	m1_on	0.274124	71.3632	No	No	Yes	Yes	9	8
80	2x38	2x41	m1_on	0	31.6929	No	Yes	No	No	7	7
81	1x54	2x44	m1_on	8.71937	25.315	No	No	No	No	7	7
82	1x54	2x47	m1_on	0	22.0669	No	No	No	No	7	9
83	1x52	8x54	m1_on	3.57746	12.0866	No	No	Yes	No	8	9
84	2x37	2x38	m1_on	0	31.4715	No	No	No	Yes	8	7
85	2x37	2x40	m1_on	1.19895	29.8917	No	No	No	No	8	9
86	2x40	8x50	m1_on	2.22068	26.7028	No	No	Yes	Yes	9	9
87	3x40	Lig	m1_on	0	45.9301	No	No	Yes	Yes	9	0
88	3x40	6x44	m1_on	0	45.1624	No	No	Yes	Yes	9	9
89	3x43	7x53	m1_on	0	43.4449	No	Yes	No	Yes	8	9
90	2x63	2x64	m1_on	0	10.1132	No	Yes	No	No	7	7
91	3x25	E1x50	m1_on	1.6669	19.877	No	No	Yes	Yes	9	9
92	3x25	3x26	m1_on	0	17.7018	No	No	No	No	9	7
93	3x26	E2.R171	m1_on	1.65859	10.1329	No	No	Yes	Yes	7	7
94	5x54	6x44	m1_on	1.53953	49.9557	No	No	Yes	Yes	9	9
95	3x47	5x54	m1_on	0.971895	48.7894	No	No	No	No	9	9
96	3x47	5x57	m1_on	0	24.8967	No	No	No	No	9	8
97	5x58	7x53	m1_on	0	25.128	No	Yes	No	Yes	9	9
98	3x47	5x58	m1_on	0	24.2815	No	No	No	Yes	9	9
99	5x47	Lig	m1_on	0	14.7539	Yes	Yes	Yes	Yes	9	0
100	5x47	5x48	m1_on	0	11.9931	Yes	Yes	No	Yes	9	7
101	5x58	6x37	m1_on	0	35.7431	No	Yes	No	No	9	9
102	6x40	7x53	m1_on	0	13.6663	No	Yes	No	Yes	8	9
103	5x62	6x37	m1_on	0	26.8652	No	Yes	No	No	7	9
104	5x62	5x66	m1_on	0	13.4744	No	Yes	No	No	7	7
105	7x34	7x38	m1_on	0	10.2608	Yes	Yes	Yes	Yes	7	7
106	3x37	4x57	m1_on	9.38668	17.9675	Yes	Yes	Yes	Yes	8	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	2x56	m1_off	7.74	0	1	0	2	2
2x53	7x42	m1_off	4.84	0	1	0	2	1
2x56	3x32	Shared	11.78	10.31	1	1	2	1
2x56	7x42	Shared	3.82	3.82	1	1	2	1
2x57	7x42	Shared	13.17	11.97	0	1	2	1
2x60	7x38	Shared	19.86	11.91	1	1	2	1
2x60	7x42	Shared	7.94	6.95	1	1	2	1
3x32	7x38	m1_off	4.6	0	1	1	1	1
3x32	7x42	Shared	10.34	9.2	1	1	1	1
3x32	Lig	Shared	4.33	9.68	1	1	1	0
3x33	4x57	Shared	15.43	16.4	1	1	1	1
3x33	4x61	Shared	3.63	3.63	1	1	1	2
3x33	E2x52	Shared	8.46	7.25	1	1	1	2
3x33	7x38	Shared	4.96	6.95	1	1	1	1
3x33	Lig	Shared	20.96	13.38	1	1	1	0
3x36	6x48	Shared	6.18	3.71	1	1	1	1
3x36	Lig	Shared	9.59	11.78	1	1	1	0
3x37	3x40	m1_off	4.3	0	1	1	1	1
3x37	4x53	Shared	5.78	5.78	1	1	1	2
3x37	4x57	Shared	8.76	8.76	1	1	1	1
3x37	5x461	Shared	4.55	4.55	1	1	1	1
3x37	Lig	Shared	5.1	10.44	1	1	1	0
3x40	5x50	m1_off	3.53	0	0	1	1	2
3x40	6x48	Shared	3.68	4.9	0	1	1	1
4x57	4x61	Shared	3.52	3.52	1	1	1	2
4x57	Lig	Shared	8	7.31	1	1	1	0
4x61	E2x52	Shared	5.89	5.89	1	1	2	2
E2.L183	E2x52	Shared	7.14	7.14	1	0	2	2
5x43	E2.L183	m1_off	4.42	0	0	0	1	2
5x43	Lig	m1_off	4.71	0	0	0	1	0
5x461	Lig	m1_off	4.02	0	1	0	1	0
5x47	5x51	Shared	7.87	7.87	1	1	1	2
5x47	6x44	m1_off	5.36	0	1	1	1	2
5x47	6x48	Shared	7.02	6.01	1	1	1	1
5x47	6x52	Shared	22.96	25.37	1	1	1	1
5x48	6x52	Shared	5.81	3.49	0	1	2	1
6x44	6x48	Shared	17.04	8.02	1	1	2	1
6x44	7x45	m1_off	3.62	0	1	1	2	2
6x47	6x48	Shared	3.64	3.64	1	1	2	1
6x47	7x45	Shared	5.85	7.31	1	1	2	2
6x48	7x41	Shared	11.75	16.98	1	1	1	1
6x48	7x45	Shared	7.91	10.17	1	1	1	2
6x48	Lig	Shared	10.91	16.25	1	1	1	0
6x51	7x34	m1_off	6.75	0	1	1	1	2
6x51	7x38	Shared	7.94	3.97	1	1	1	1
6x51	Lig	Shared	14.22	8.36	1	1	1	0
6x52	Lig	m1_off	10.52	0	0	1	1	0
7x38	7x42	m1_off	6.95	0	1	1	1	1
7x38	Lig	Shared	16.47	10.03	1	1	1	0
7x41	Lig	Shared	6.08	4.53	1	1	1	0
7x42	Lig	Shared	4.49	5.85	1	1	1	0
4x56	4x57	m1_off	3.42	0	0	0	2	1
3x41	4x53	m1_off	3.07	0	0	0	2	2
5x44	Lig	m1_off	2.01	0	0	0	1	0
2x53	3x36	m1_on	0	4.64	1	0	2	1
2x57	7x39	m1_on	0	8.14	0	1	2	2
2x60	7x39	m1_on	0	4.82	1	1	2	2
3x33	6x51	m1_on	0	7.94	1	1	1	1
3x37	3x41	m1_on	0	5.44	1	1	1	2
3x40	6x44	m1_on	0	3.93	0	1	1	2
3x40	Lig	m1_on	0	5.31	0	1	1	0
4x57	5x43	m1_on	0	4.85	1	1	1	1
5x47	5x48	m1_on	0	11.35	1	1	1	2
5x47	6x49	m1_on	0	3.89	1	1	1	2
5x47	Lig	m1_on	0	5.21	1	1	1	0
5x51	6x44	m1_on	0	3.93	0	0	2	2
6x51	6x52	m1_on	0	8.14	1	1	1	1
6x51	6x55	m1_on	0	6.31	1	1	1	2
7x39	7x42	m1_on	0	18.33	0	1	2	1
7x34	7x38	m1_on	0	2.89	1	0	2	1
3x37	4x56	m1_on	0	2.66	1	1	1	2
5x44	5x48	m1_on	0	1.33	0	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	m1_off	5CXV-M₁-Tiotropium
	m1_on	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2

Network Difference
Value	m1_off	m1_on
I_min	3.5	3.42
Number of Linked Nodes	265	262
Number of Specific Nodes	25 (9.43%)	22 (8.40%)
Number of Shared Nodes	240 (90.57%)	240 (91.60%)
Number of Links	303	289
Number of Specific Links	131 (43.23%)	117 (40.48%)
Number of Shared Links	172 (56.77%)	172 (59.52%)
Number of Hubs	40	39
Number of Specific Hubs	16 (40.00%)	15 (38.46%)
Number of Shared Hubs	24 (60.00%)	24 (61.54%)
Average % Shared Neighbours (Jaccard)	39.50
Average % Shared Neighbours (Otsuka)	48.09
Average % Shared Neighbours (Overlap Coefficient)	56.52
Average % Shared Cliques (k3-6)	57.65
Graphlets Similarity	0.715382

Paths Difference
Value	m1_off	m1_on
Number Of Nodes in MetaPath	66	69
Specific Nodes in MetaPath	21 (31.82%)	24 (34.78%)
Shared Nodes in MetaPath	240 (90.57%)	240 (90.57%)
Number Of Links MetaPath	67	71
Specific Links in MetaPath	35 (52.24%)	39 (54.93%)
Shared Links in MetaPath	172 (56.77%)	172 (56.77%)
Number of Shortest Paths	73816	48563
Length Of Smallest Path	3	3
Average Path Length	14.8546	13.8661
Length of Longest Path	34	32
Minimum Path Strength	1.32	1.335
Average Path Strength	6.33489	6.61867
Maximum Path Strength	18.1467	16.755
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.923091	0.945062
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.57143	3.84615
Average % Of Corr. Nodes	44.5287	62.0203
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	44.5144	46.6714
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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