psnGPCR

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Orange: nodes, hubs and links specific of m1_off_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m1_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	m1_off_allo Int. Strength	m1_off Int. Strength	m1_off_allo Hub1?	m1_off Hub1?	m1_off_allo Hub2?	m1_off Hub2?	ConSurf1	ConSurf2
1	1x29	1x31	m1_off_allo	4.74	0	No	No	Yes	No	2	6
2	1x29	1x32	m1_off_allo	7.07	0	No	No	No	No	2	4
3	1x30	1x31	m1_off_allo	28.48	0	No	No	Yes	No	4	6
4	1x31	7x32	m1_off_allo	14.17	0	Yes	No	No	No	6	4
5	1x31	7x36	m1_off_allo	6.65	0	Yes	No	No	No	6	5
6	1x32	2x64	m1_off_allo	5.96	0	No	No	No	No	4	7
7	1x34	7x39	m1_off_allo	6.01	0	No	No	Yes	No	3	8
8	1x35	7x39	m1_off_allo	17.62	0	No	No	Yes	No	7	8
9	1x36	2x65	m1_off_allo	5.13	0	No	No	No	No	5	6
10	1x38	7x39	m1_off_allo	3.64	0	No	No	Yes	No	4	8
11	1x39	2x57	m1_off_allo	4.52	0	No	Yes	No	Yes	6	8
12	1x42	7x39	m1_off_allo	4.56	0	No	No	Yes	No	7	8
13	1x48	1x49	m1_off_allo	3.64	0	No	No	No	No	5	9
14	1x49	1x52	m1_off_allo	5.13	0	No	No	Yes	No	9	8
15	1x51	2x51	m1_off_allo	4.15	0	No	No	Yes	No	5	8
16	1x53	8x50	m1_off_allo	3.93	0	No	No	Yes	Yes	9	9
17	8x53	I1x50	m1_off_allo	5.9	0	No	No	No	No	8	9
18	2x41	I1x51	m1_off_allo	5.97	0	No	No	No	No	7	7
19	2x39	3x50	m1_off_allo	13.26	0	No	No	No	Yes	8	9
20	2x40	8x47	m1_off_allo	4.09	0	No	No	No	No	9	9
21	2x45	4x46	m1_off_allo	9.29	0	No	No	No	No	9	9
22	2x46	3x42	m1_off_allo	5.49	0	No	No	No	No	9	8
23	2x46	7x53	m1_off_allo	3.52	0	No	No	No	No	9	9
24	2x50	3x39	m1_off_allo	13.1	0	Yes	Yes	Yes	No	9	9
25	2x60	7x35	m1_off_allo	10.1	0	Yes	Yes	No	No	7	6
26	2x60	Allo1	m1_off_allo	9.26	0	Yes	Yes	Yes	No	7	0
27	2x63	E2x50	m1_off_allo	4.03	0	Yes	No	Yes	No	7	9
28	2x63	Allo1	m1_off_allo	6.17	0	Yes	No	Yes	No	7	0
29	3x29	E2x50	m1_off_allo	4.76	0	No	No	Yes	No	7	9
30	3x37	3x41	m1_off_allo	8.16	0	Yes	Yes	No	No	8	7
31	3x39	3x43	m1_off_allo	3.64	0	Yes	No	No	No	9	8
32	3x39	6x48	m1_off_allo	6	0	Yes	No	Yes	Yes	9	8
33	3x39	7x45	m1_off_allo	12.05	0	Yes	No	Yes	No	9	9
34	3x39	7x46	m1_off_allo	3.95	0	Yes	No	No	No	9	9
35	3x39	7x49	m1_off_allo	6.03	0	Yes	No	Yes	No	9	9
36	3x49	3x53	m1_off_allo	4.42	0	Yes	No	No	No	9	9
37	3x53	I2x57	m1_off_allo	3.95	0	No	No	Yes	Yes	9	8
38	3x54	5x65	m1_off_allo	6.35	0	No	No	No	No	8	8
39	4x38	4x41	m1_off_allo	5.17	0	No	No	No	No	8	8
40	4x64	4x67	m1_off_allo	4.56	0	Yes	No	No	No	7	4
41	4x64	Allo1	m1_off_allo	8.45	0	Yes	No	Yes	No	7	0
42	E2.E170	E2.T172	m1_off_allo	5.64	0	No	No	No	No	4	4
43	Allo1	E2.E170	m1_off_allo	29.35	0	Yes	No	No	No	0	4
44	Allo1	E2.T172	m1_off_allo	12.97	0	Yes	No	No	No	0	4
45	Allo1	E2.L174	m1_off_allo	30.82	0	Yes	No	No	No	0	3
46	Allo1	E2.Q177	m1_off_allo	12.4	0	Yes	No	Yes	No	0	4
47	Allo1	E2x51	m1_off_allo	13.88	0	Yes	No	No	No	0	4
48	5x39	E2.L183	m1_off_allo	4.28	0	No	No	Yes	Yes	8	7
49	5x36	5x38	m1_off_allo	4.12	0	No	No	No	No	7	5
50	5x37	Allo1	m1_off_allo	13.01	0	No	No	Yes	No	5	0
51	5x47	5x48	m1_off_allo	9.28	0	Yes	Yes	Yes	No	9	7
52	5x47	6x49	m1_off_allo	3.89	0	Yes	Yes	No	No	9	7
53	5x60	5x64	m1_off_allo	9.3	0	No	No	No	No	7	7
54	5x63	5x66	m1_off_allo	10.47	0	No	No	No	No	5	7
55	5x63	5x67	m1_off_allo	3.62	0	No	No	No	No	5	5
56	6x27	6x30	m1_off_allo	7.95	0	No	No	No	No	5	9
57	6x29	6x30	m1_off_allo	4.05	0	No	No	No	No	7	9
58	6x54	7x33	m1_off_allo	5.65	0	No	No	No	No	6	5
59	7x31	Allo1	m1_off_allo	21.09	0	No	No	Yes	No	3	0
60	7x34	Allo1	m1_off_allo	20.23	0	Yes	Yes	Yes	No	7	0
61	7x35	Allo1	m1_off_allo	16.76	0	No	No	Yes	No	6	0
62	7x38	Allo1	m1_off_allo	9.26	0	Yes	Yes	Yes	No	7	0
63	7x39	7x43	m1_off_allo	7.36	0	Yes	No	No	No	8	7
64	7x40	7x43	m1_off_allo	4.47	0	No	No	No	No	8	7
65	7x45	7x49	m1_off_allo	5.45	0	Yes	No	Yes	No	9	9
66	7x49	7x53	m1_off_allo	5.81	0	Yes	No	No	No	9	9
67	8x47	8x49	m1_off_allo	4.69	0	No	No	No	No	9	7
68	8x50	8x54	m1_off_allo	7.5	0	Yes	Yes	Yes	Yes	9	9
69	8x55	8x59	m1_off_allo	4.86	0	No	No	No	No	6	5
70	Allo1	Allo1	m1_off_allo	466.88	0	Yes	No	Yes	No	0	0
71	8x57	CT.W437	m1_off_allo	3.42	0	Yes	No	No	No	8	3
72	5x40	5x43	m1_off_allo	3.14	0	No	No	No	No	7	8
73	Allo1	E2.S184	m1_off_allo	3.1	0	Yes	No	No	No	0	6
74	4x63	4x66	m1_off_allo	3.09	0	No	No	No	No	6	5
75	5x51	5x54	m1_off_allo	3.04	0	No	No	No	No	7	9
76	5x41	5x42	m1_off_allo	3.01	0	Yes	Yes	No	No	7	6
77	1x47	2x51	m1_off_allo	2.98	0	No	No	Yes	No	7	8
78	6x52	6x55	m1_off_allo	2.96	0	No	No	No	No	8	8
79	1x44	1x48	m1_off_allo	2.95	0	No	No	No	No	5	5
80	2x51	2x55	m1_off_allo	2.95	0	Yes	No	No	No	8	5
81	2x59	2x62	m1_off_allo	2.95	0	No	No	No	No	7	7
82	7x48	7x51	m1_off_allo	2.92	0	No	No	No	No	6	6
83	3x43	6x40	m1_off_allo	2.85	0	No	No	No	No	8	8
84	3x44	5x54	m1_off_allo	2.83	0	No	No	No	No	7	9
85	3x45	4x45	m1_off_allo	2.83	0	No	No	No	No	7	7
86	7x45	7x48	m1_off_allo	2.83	0	Yes	No	No	No	9	6
87	1x52	8x57	m1_off_allo	2.77	0	Yes	No	Yes	No	8	8
88	8x56	8x57	m1_off_allo	2.77	0	No	No	Yes	No	6	8
89	5x44	5x48	m1_off_allo	2.67	0	No	No	Yes	No	7	7
90	2x48	4x50	m1_off_allo	2.61	0	No	No	Yes	Yes	6	9
91	5x48	6x53	m1_off_allo	2.42	0	Yes	No	No	No	7	7
92	2x52	4x50	m1_off_allo	2.35	0	No	No	Yes	Yes	8	9
93	5x58	6x41	m1_off_allo	2.34	0	No	No	No	No	9	7
94	E2.A175	E2.G176	m1_off_allo	1.95	0	No	No	No	No	3	2
95	NT.A17	NT.P18	m1_off_allo	1.87	0	No	No	No	No	1	2
96	1x39	1x40	m1_off_allo	1.82	0	No	Yes	No	No	6	5
97	6x39	7x56	m1_off_allo	1.81	0	No	No	No	No	8	8
98	6x43	7x52	m1_off_allo	1.81	0	No	No	No	No	7	8
99	7x37	7x40	m1_off_allo	1.71	0	No	No	No	No	6	8
100	3x34	4x58	m1_off_allo	1.7	0	No	No	No	No	8	6
101	3x34	4x53	m1_off_allo	1.62	0	No	No	No	No	8	8
102	4x52	4x53	m1_off_allo	1.62	0	No	No	No	No	5	8
103	5x52	5x53	m1_off_allo	1.59	0	No	No	No	No	5	7
104	5x53	5x56	m1_off_allo	1.59	0	No	No	No	No	7	5
105	2x39	6x33	m1_off_allo	1.56	0	No	No	No	No	8	9
106	5x61	5x65	m1_off_allo	1.52	0	No	No	No	No	9	8
107	6x32	6x36	m1_off_allo	1.5	0	No	No	No	No	8	8
108	1x59	8x57	m1_off_allo	1.49	0	No	No	Yes	No	7	8
109	1x55	1x58	m1_off_allo	1.45	0	No	No	No	No	6	5
110	7x54	8x51	m1_off_allo	1.38	0	No	No	Yes	No	8	9
111	7x55	8x51	m1_off_allo	1.21	0	No	No	Yes	No	7	9
112	8x51	8x52	m1_off_allo	1.19	0	Yes	No	No	No	9	6
113	1x29	NT.G21	Shared	4.06	4.06	No	No	No	No	2	6
114	1x34	1x38	Shared	6.49	5.19	No	No	No	No	3	4
115	1x39	2x61	Shared	14.13	10.99	No	Yes	No	No	6	8
116	1x43	2x58	Shared	8.94	8.94	No	No	No	No	7	9
117	1x46	2x54	Shared	3.64	3.64	No	No	No	No	8	8
118	1x46	7x47	Shared	6.28	9.42	No	No	No	No	8	8
119	1x49	7x50	Shared	4.06	4.06	No	No	No	No	9	9
120	1x50	2x47	Shared	4.69	4.69	Yes	Yes	No	No	9	9
121	1x50	2x50	Shared	8.08	6.73	Yes	Yes	Yes	Yes	9	9
122	1x50	7x50	Shared	9.77	13.03	Yes	Yes	No	No	9	9
123	1x52	8x54	Shared	10.96	13.4	Yes	No	Yes	Yes	8	9
124	1x52	8x58	Shared	6.92	6.92	Yes	No	No	No	8	8
125	1x53	8x54	Shared	5.24	3.93	No	No	Yes	Yes	9	9
126	1x54	2x44	Shared	5.54	4.15	No	No	No	No	7	7
127	1x55	8x57	Shared	5.71	5.71	No	No	Yes	No	6	8
128	1x56	8x54	Shared	6.61	5.28	No	No	Yes	Yes	9	9
129	1x57	I1x51	Shared	6.2	6.2	No	No	No	No	8	7
130	1x57	2x41	Shared	12.38	4.13	No	No	No	No	8	7
131	1x57	2x44	Shared	8.53	13.4	No	No	No	No	8	7
132	1x60	I1x49	Shared	6.57	6.57	No	Yes	No	No	8	7
133	1x60	I1x50	Shared	12.36	6.87	No	Yes	No	No	8	9
134	1x60	8x53	Shared	8.77	8.77	No	Yes	No	No	8	8
135	I1x48	I1x51	Shared	7.51	4.5	No	No	No	No	7	7
136	8x50	I1x50	Shared	10.96	13.4	Yes	Yes	No	No	9	9
137	2x37	2x40	Shared	8.77	8.77	No	No	No	No	8	9
138	2x38	I2x57	Shared	10.46	9.15	No	No	Yes	Yes	7	8
139	2x38	4x39	Shared	3.53	3.53	No	No	No	No	7	5
140	2x39	I2x57	Shared	6.03	7.23	No	No	Yes	Yes	8	8
141	2x40	8x50	Shared	8.46	7.25	No	No	Yes	Yes	9	9
142	2x41	4x39	Shared	6.95	5.56	No	No	No	No	7	5
143	2x42	3x45	Shared	3.65	7.31	Yes	Yes	No	No	8	7
144	2x42	3x46	Shared	8.79	5.02	Yes	Yes	No	No	8	9
145	2x42	3x49	Shared	4.78	7.17	Yes	Yes	Yes	No	8	9
146	2x42	4x46	Shared	3.77	6.28	Yes	Yes	No	No	8	9
147	2x43	7x53	Shared	18.76	21.1	No	No	No	No	9	9
148	2x45	3x42	Shared	10.43	7.45	No	No	No	No	9	8
149	2x45	4x50	Shared	3.71	6.18	No	No	Yes	Yes	9	9
150	2x50	7x46	Shared	10.31	8.83	Yes	Yes	No	No	9	9
151	2x50	7x49	Shared	8.08	8.08	Yes	Yes	Yes	No	9	9
152	2x53	2x54	Shared	3.53	3.53	Yes	Yes	No	No	8	8
153	2x53	2x56	Shared	7.74	7.74	Yes	Yes	No	No	8	8
154	2x53	7x42	Shared	4.84	4.84	Yes	Yes	Yes	Yes	8	8
155	2x53	7x46	Shared	9.29	7.74	Yes	Yes	No	No	8	9
156	2x55	2x551	Shared	11.67	14.27	No	No	No	No	5	6
157	2x551	3x31	Shared	3.65	4.87	No	No	No	No	6	6
158	2x56	3x32	Shared	11.78	11.78	No	No	No	Yes	8	9
159	2x56	7x42	Shared	3.82	3.82	No	No	Yes	Yes	8	8
160	2x57	7x42	Shared	7.18	13.17	No	Yes	Yes	Yes	8	8
161	2x59	3x28	Shared	11.39	10.25	No	No	No	Yes	7	7
162	2x60	2x64	Shared	3.52	3.52	Yes	Yes	No	No	7	7
163	2x60	7x38	Shared	12.91	19.86	Yes	Yes	Yes	Yes	7	7
164	2x60	7x42	Shared	5.96	7.94	Yes	Yes	Yes	Yes	7	8
165	2x63	E1x50	Shared	9.65	7.72	Yes	No	Yes	Yes	7	9
166	2x63	E2.Q177	Shared	10.15	6.76	Yes	No	Yes	No	7	4
167	2x64	7x35	Shared	9.28	6.63	No	No	No	No	7	6
168	E1x50	E1x52	Shared	5.69	5.69	Yes	Yes	No	No	9	7
169	3x24	E1x50	Shared	3.89	2.59	No	No	Yes	Yes	6	9
170	3x25	E1x50	Shared	7.84	7.84	No	No	Yes	Yes	9	9
171	3x28	E1x50	Shared	8.43	9.37	No	Yes	Yes	Yes	7	9
172	E1x50	E2x50	Shared	11.75	7.84	Yes	Yes	Yes	No	9	9
173	3x22	E2.R171	Shared	10.35	10.35	No	No	Yes	Yes	4	7
174	3x25	E2x50	Shared	7.28	7.28	No	No	Yes	No	9	9
175	3x26	4x65	Shared	5.22	6.53	No	No	No	No	7	7
176	3x26	E2.R171	Shared	10.72	8.34	No	No	Yes	Yes	7	7
177	3x29	E2x52	Shared	4.28	4.28	No	No	Yes	Yes	7	7
178	3x32	7x42	Shared	10.34	10.34	No	Yes	Yes	Yes	9	8
179	3x32	Lig	Shared	10.88	4.33	No	Yes	Yes	Yes	9	0
180	3x33	4x57	Shared	11.58	15.43	Yes	Yes	No	Yes	8	8
181	3x33	4x61	Shared	3.63	3.63	Yes	Yes	No	Yes	8	7
182	3x33	E2x52	Shared	9.67	8.46	Yes	Yes	Yes	Yes	8	7
183	3x33	Lig	Shared	11.96	20.96	Yes	Yes	Yes	Yes	8	0
184	3x36	6x48	Shared	4.94	6.18	No	No	Yes	Yes	8	8
185	3x36	Lig	Shared	8.75	9.59	No	No	Yes	Yes	8	0
186	3x37	3x40	Shared	4.3	4.3	Yes	Yes	No	No	8	9
187	3x37	4x53	Shared	5.78	5.78	Yes	Yes	No	No	8	8
188	3x37	4x57	Shared	9.86	8.76	Yes	Yes	No	Yes	8	8
189	3x37	Lig	Shared	4.85	5.1	Yes	Yes	Yes	Yes	8	0
190	3x38	4x50	Shared	10.37	9.08	No	No	Yes	Yes	8	9
191	3x42	4x50	Shared	6.78	4.52	No	No	Yes	Yes	8	9
192	3x43	6x44	Shared	8.53	8.53	No	No	Yes	Yes	8	9
193	3x47	5x54	Shared	6.13	6.13	No	No	No	No	9	9
194	3x48	3x52	Shared	5.36	5.36	No	No	Yes	Yes	7	7
195	3x48	5x57	Shared	12.18	7.31	No	No	No	No	7	8
196	3x49	I2x53	Shared	11.49	8.05	Yes	No	Yes	Yes	9	9
197	3x49	I2x57	Shared	16.68	13.1	Yes	No	Yes	Yes	9	8
198	3x50	6x37	Shared	7.29	4.86	No	Yes	No	No	9	9
199	3x51	3x52	Shared	5.16	6.19	No	Yes	Yes	Yes	8	7
200	3x51	3x55	Shared	11.24	16.23	No	Yes	No	No	8	8
201	3x51	5x57	Shared	5.86	3.52	No	Yes	No	No	8	8
202	3x52	3x56	Shared	6.41	6.41	Yes	Yes	No	Yes	7	7
203	3x52	I2x53	Shared	9.28	11.35	Yes	Yes	Yes	Yes	7	9
204	3x53	I2x53	Shared	6.36	3.82	No	No	Yes	Yes	9	9
205	3x54	5x68	Shared	3.92	5.23	No	No	No	Yes	8	8
206	3x55	5x64	Shared	5.64	4.23	No	No	No	No	8	7
207	I2x53	I2x57	Shared	5.14	8.23	Yes	Yes	Yes	Yes	9	8
208	4x38	4x39	Shared	5.25	3.5	No	No	No	No	8	5
209	4x54	4x58	Shared	8.32	8.32	No	No	No	No	6	6
210	4x60	E2.F182	Shared	4.16	4.16	No	No	Yes	Yes	7	6
211	4x61	E2x52	Shared	7.36	5.89	No	Yes	Yes	Yes	7	7
212	4x62	4x63	Shared	6.09	6.09	No	No	No	No	6	6
213	4x64	4x68	Shared	7.36	8.58	Yes	No	No	No	7	4
214	4x64	E2.Q181	Shared	4.38	5.48	Yes	No	No	No	7	8
215	4x64	E2.F182	Shared	19.04	10.02	Yes	No	Yes	Yes	7	6
216	4x65	4x66	Shared	12.4	13.53	No	No	No	No	7	5
217	4x65	E2.R171	Shared	14.02	10.51	No	No	Yes	Yes	7	7
218	E2.R171	E2.V173	Shared	7.85	7.85	Yes	Yes	No	No	7	4
219	E2.Q181	E2.T172	Shared	9.92	9.92	No	No	No	No	8	4
220	E2.V173	E2x51	Shared	12.62	16.4	No	No	No	No	4	4
221	E2.L174	E2.Q177	Shared	5.32	3.99	No	No	Yes	No	3	4
222	E2.F182	E2x52	Shared	7.54	5.02	Yes	Yes	Yes	Yes	6	7
223	E2.L183	E2x52	Shared	8.56	7.14	Yes	Yes	Yes	Yes	7	7
224	E2.F182	E2.L183	Shared	4.87	7.31	Yes	Yes	Yes	Yes	6	7
225	5x43	E2.L183	Shared	7.37	4.42	No	No	Yes	Yes	8	7
226	5x36	5x39	Shared	8.23	5.49	No	No	No	No	7	8
227	5x41	5x45	Shared	8.71	7.46	Yes	Yes	No	No	7	6
228	5x41	6x59	Shared	11.67	5.19	Yes	Yes	No	No	7	8
229	5x45	5x48	Shared	5.99	4.79	No	No	Yes	No	6	7
230	5x461	Lig	Shared	8.04	4.02	No	No	Yes	Yes	8	0
231	5x47	5x51	Shared	7.87	7.87	Yes	Yes	No	No	9	7
232	5x47	6x44	Shared	4.29	5.36	Yes	Yes	Yes	Yes	9	9
233	5x47	6x48	Shared	6.01	7.02	Yes	Yes	Yes	Yes	9	8
234	5x47	6x52	Shared	25.37	22.96	Yes	Yes	No	No	9	8
235	5x58	6x38	Shared	6.36	5.09	No	No	No	No	9	7
236	5x59	5x60	Shared	5	13.99	No	No	No	No	4	7
237	5x64	5x67	Shared	6.57	5.26	No	No	No	No	7	5
238	6x25	6x27	Shared	7.31	4.87	No	No	No	No	3	5
239	6x26	6x28	Shared	8.08	3.23	No	No	No	No	6	5
240	6x36	7x56	Shared	6.76	1.69	No	No	No	No	8	8
241	6x37	6x41	Shared	4.15	6.92	No	No	No	No	9	7
242	6x39	7x52	Shared	3.61	1.81	No	No	No	No	8	8
243	6x42	6x46	Shared	5.54	2.77	No	No	No	No	7	5
244	6x44	6x48	Shared	21.05	17.04	Yes	Yes	Yes	Yes	9	8
245	6x44	7x45	Shared	4.83	3.62	Yes	Yes	Yes	No	9	9
246	6x45	6x49	Shared	4.56	3.04	No	No	No	No	7	7
247	6x47	6x48	Shared	4.85	3.64	No	Yes	Yes	Yes	8	8
248	6x47	7x40	Shared	5.9	4.42	No	Yes	No	No	8	8
249	6x47	7x45	Shared	7.31	5.85	No	Yes	Yes	No	8	9
250	6x48	7x41	Shared	14.37	11.75	Yes	Yes	No	No	8	8
251	6x48	7x45	Shared	7.91	7.91	Yes	Yes	Yes	No	8	9
252	6x48	Lig	Shared	14.11	10.91	Yes	Yes	Yes	Yes	8	0
253	6x49	6x50	Shared	5.25	3.5	No	No	No	No	7	9
254	6x51	7x34	Shared	6.75	6.75	No	No	Yes	Yes	8	7
255	6x51	7x38	Shared	6.95	7.94	No	No	Yes	Yes	8	7
256	6x51	Lig	Shared	11.96	14.22	No	No	Yes	Yes	8	0
257	6x52	Lig	Shared	11.01	10.52	No	No	Yes	Yes	8	0
258	6x54	E3.V395	Shared	4.56	6.09	No	No	No	Yes	6	6
259	6x58	7x34	Shared	7.41	4.94	No	No	Yes	Yes	5	7
260	6x59	6x60	Shared	3.89	9.08	No	No	No	No	8	5
261	6x61	E3.C394	Shared	5.46	7.28	No	No	No	No	6	8
262	7x30	E3.V395	Shared	3.53	3.53	No	No	No	Yes	6	6
263	7x34	E3.V395	Shared	9.81	9.81	Yes	Yes	No	Yes	7	6
264	7x30	7x33	Shared	9.85	9.85	No	No	No	No	6	5
265	7x38	7x42	Shared	6.95	6.95	Yes	Yes	Yes	Yes	7	8
266	7x38	Lig	Shared	13.67	16.47	Yes	Yes	Yes	Yes	7	0
267	7x41	Lig	Shared	4.63	6.08	No	No	Yes	Yes	8	0
268	8x47	8x50	Shared	10.87	7.25	No	No	Yes	Yes	9	9
269	8x48	8x51	Shared	12.38	1.24	No	No	Yes	No	5	9
270	8x59	CT.R436	Shared	9.72	14.58	No	No	No	No	5	4
271	4x56	4x57	Shared	3.42	3.42	No	No	No	Yes	8	8
272	3x44	5x50	Shared	3.28	4.93	No	No	No	No	7	9
273	5x49	5x50	Shared	3.28	1.64	No	No	No	No	7	9
274	2x52	3x35	Shared	3.25	3.25	No	No	No	No	8	7
275	6x43	7x48	Shared	3.25	4.87	No	No	No	No	7	6
276	2x62	2x66	Shared	3.01	1.51	No	No	No	No	7	6
277	4x51	4x55	Shared	2.98	2.98	No	No	No	No	4	5
278	2x61	2x65	Shared	2.95	2.95	No	No	No	No	8	6
279	E1x49	E1x51	Shared	2.93	2.93	No	No	No	No	5	4
280	5x68	I2x50	Shared	2.88	2.88	No	Yes	No	No	8	8
281	7x54	8x54	Shared	2.77	4.16	No	No	Yes	Yes	8	9
282	1x50	2x51	Shared	2.75	2.75	Yes	Yes	Yes	No	9	8
283	2x66	E1x49	Shared	2.63	2.63	No	No	No	No	6	5
284	2x49	4x50	Shared	2.59	2.59	No	No	Yes	Yes	9	9
285	4x38	4x40	Shared	2.59	9.06	No	No	No	No	8	6
286	3x50	5x61	Shared	2.51	11.27	No	Yes	No	No	9	9
287	4x41	I2x56	Shared	2.48	4.95	No	No	No	No	8	6
288	5x41	6x56	Shared	2.44	7.31	Yes	Yes	No	No	7	7
289	I2x54	I2x57	Shared	2.13	2.13	No	No	Yes	Yes	7	8
290	4x58	4x59	Shared	1.87	1.87	No	No	No	No	6	8
291	1x40	1x43	Shared	1.86	1.86	No	No	No	No	5	7
292	5x51	5x55	Shared	1.71	1.71	No	No	No	No	7	5
293	7x36	7x37	Shared	1.71	1.71	No	No	No	No	5	6
294	2x38	4x42	Shared	1.7	1.7	No	No	No	No	7	8
295	1x45	7x47	Shared	1.68	1.68	No	No	No	No	5	8
296	E2.G176	E2.Q177	Shared	1.64	1.64	No	No	Yes	No	2	4
297	3x41	4x49	Shared	1.61	3.22	No	No	No	No	7	8
298	3x30	4x62	Shared	1.58	4.73	No	No	No	No	8	6
299	3x44	5x53	Shared	1.49	2.98	No	No	No	No	7	7
300	3x21	E1x50	Shared	1.41	2.81	No	No	Yes	Yes	7	9
301	3x23	3x27	Shared	1.38	2.77	No	No	No	No	4	6
302	3x27	4x62	Shared	1.38	1.38	No	No	No	No	6	6
303	4x44	4x48	Shared	1.38	4.15	No	No	No	No	2	4
304	4x48	4x51	Shared	1.38	2.77	No	No	No	No	4	4
305	3x56	I2x52	Shared	1.32	2.64	No	Yes	No	No	7	7
306	4x54	4x55	Shared	1.31	1.31	No	No	No	No	6	5
307	5x68	6x27	Shared	1.21	2.43	No	Yes	No	No	8	5
308	8x56	CT.R436	Shared	1.21	2.43	No	No	No	No	6	4
309	1x31	NT.K20	m1_off	0	6.78	Yes	No	No	Yes	6	5
310	2x64	NT.K20	m1_off	0	4.23	No	No	No	Yes	7	5
311	7x35	NT.K20	m1_off	0	4.05	No	No	No	Yes	6	5
312	1x32	2x65	m1_off	0	7.45	No	No	No	No	4	6
313	1x35	2x65	m1_off	0	7.14	No	No	No	No	7	6
314	1x39	7x39	m1_off	0	8.49	No	Yes	Yes	No	6	8
315	1x42	2x57	m1_off	0	4.24	No	No	No	Yes	7	8
316	1x42	7x47	m1_off	0	5.9	No	No	No	No	7	8
317	1x46	2x57	m1_off	0	4.52	No	No	No	Yes	8	8
318	1x51	1x55	m1_off	0	4.28	No	No	No	No	5	6
319	1x53	7x53	m1_off	0	6.31	No	No	No	No	9	9
320	1x54	1x58	m1_off	0	4.23	No	No	No	No	7	5
321	1x56	8x50	m1_off	0	3.96	No	No	Yes	Yes	9	9
322	1x59	CT.W437	m1_off	0	14.71	No	No	No	No	7	3
323	1x60	CT.W437	m1_off	0	7.91	No	Yes	No	No	8	3
324	CT.K439	I1x48	m1_off	0	6.01	No	No	No	No	0	7
325	8x49	I1x49	m1_off	0	4.53	No	No	No	No	7	7
326	2x40	I1x50	m1_off	0	4.12	No	No	No	No	9	9
327	2x46	2x50	m1_off	0	4.07	No	No	Yes	Yes	9	9
328	2x52	3x31	m1_off	0	4.28	No	No	No	No	8	6
329	2x60	3x28	m1_off	0	6.75	Yes	Yes	No	Yes	7	7
330	3x28	3x29	m1_off	0	7.97	No	Yes	No	No	7	7
331	3x28	E2x50	m1_off	0	3.92	No	Yes	Yes	No	7	9
332	3x32	7x38	m1_off	0	4.6	No	Yes	Yes	Yes	9	7
333	3x33	7x38	m1_off	0	4.96	Yes	Yes	Yes	Yes	8	7
334	3x34	4x54	m1_off	0	5.24	No	No	No	No	8	6
335	3x37	5x461	m1_off	0	4.55	Yes	Yes	No	No	8	8
336	3x40	5x50	m1_off	0	3.53	No	No	No	No	9	9
337	3x40	6x48	m1_off	0	3.68	No	No	Yes	Yes	9	8
338	3x43	5x54	m1_off	0	5.65	No	No	No	No	8	9
339	3x43	6x41	m1_off	0	5.54	No	No	No	No	8	7
340	3x50	6x34	m1_off	0	4.15	No	Yes	No	No	9	8
341	3x51	3x56	m1_off	0	4.12	No	Yes	No	Yes	8	7
342	3x51	5x61	m1_off	0	4.84	No	Yes	No	No	8	9
343	3x54	5x61	m1_off	0	4.61	No	No	No	No	8	9
344	3x55	3x56	m1_off	0	10.35	No	No	No	Yes	8	7
345	I2x53	I2x56	m1_off	0	3.58	Yes	Yes	No	No	9	6
346	4x41	4x45	m1_off	0	3.72	No	No	No	No	8	7
347	4x46	4x47	m1_off	0	3.53	No	No	No	No	9	4
348	4x57	4x61	m1_off	0	3.52	No	Yes	No	Yes	8	7
349	4x57	Lig	m1_off	0	8	No	Yes	Yes	Yes	8	0
350	E2.L174	E2x51	m1_off	0	3.52	No	No	No	No	3	4
351	5x40	E2.L183	m1_off	0	7.37	No	No	Yes	Yes	7	7
352	5x36	E2.S184	m1_off	0	5.78	No	No	No	No	7	6
353	5x36	5x37	m1_off	0	4.74	No	No	No	No	7	5
354	5x41	6x55	m1_off	0	3.93	Yes	Yes	No	No	7	8
355	5x43	Lig	m1_off	0	4.71	No	No	Yes	Yes	8	0
356	5x48	6x52	m1_off	0	5.81	Yes	No	No	No	7	8
357	5x54	6x44	m1_off	0	3.73	No	No	Yes	Yes	9	9
358	5x59	5x63	m1_off	0	10	No	No	No	No	4	5
359	5x62	5x63	m1_off	0	15.43	No	No	No	No	7	5
360	5x65	5x68	m1_off	0	5.17	No	No	No	Yes	8	8
361	5x68	6x30	m1_off	0	12.79	No	Yes	No	No	8	9
362	6x29	8x47	m1_off	0	6.99	No	No	No	No	7	9
363	6x36	7x53	m1_off	0	4.99	No	No	No	No	8	9
364	6x40	7x49	m1_off	0	7.08	No	No	Yes	No	8	9
365	6x40	7x52	m1_off	0	4.91	No	No	No	No	8	8
366	6x50	7x40	m1_off	0	4.93	No	No	No	No	9	8
367	6x54	7x34	m1_off	0	8.14	No	No	Yes	Yes	6	7
368	6x56	6x60	m1_off	0	4.87	No	No	No	No	7	5
369	7x33	E3.V395	m1_off	0	4.47	No	No	No	Yes	5	6
370	7x42	Lig	m1_off	0	4.49	Yes	Yes	Yes	Yes	8	0
371	8x48	8x52	m1_off	0	11.06	No	No	No	No	5	6
372	6x54	7x37	m1_off	0	3.49	No	No	No	No	6	6
373	3x38	4x53	m1_off	0	3.42	No	No	No	No	8	8
374	8x56	CT.W437	m1_off	0	3.42	No	No	No	No	6	3
375	1x53	2x47	m1_off	0	3.39	No	No	No	No	9	9
376	1x31	NT.G21	m1_off	0	3.29	Yes	No	No	No	6	6
377	2x53	3x35	m1_off	0	3.25	Yes	Yes	No	No	8	7
378	3x30	4x61	m1_off	0	3.25	No	No	No	Yes	8	7
379	1x54	2x48	m1_off	0	3.17	No	No	No	No	7	6
380	7x55	7x56	m1_off	0	3.17	No	No	No	No	7	8
381	1x43	2x57	m1_off	0	3.07	No	No	No	Yes	7	8
382	3x41	4x53	m1_off	0	3.07	No	No	No	No	7	8
383	7x43	7x48	m1_off	0	3.07	No	No	No	No	7	6
384	1x32	NT.K20	m1_off	0	3.04	No	No	No	Yes	4	5
385	6x49	6x53	m1_off	0	3.04	No	No	No	No	7	7
386	2x46	3x39	m1_off	0	3	No	No	Yes	No	9	9
387	1x42	7x43	m1_off	0	2.98	No	No	No	No	7	7
388	4x52	4x56	m1_off	0	2.98	No	No	No	No	5	8
389	5x53	5x57	m1_off	0	2.98	No	No	No	No	7	8
390	1x48	1x52	m1_off	0	2.95	No	No	Yes	No	5	8
391	5x49	5x52	m1_off	0	2.95	No	No	No	No	7	5
392	6x46	6x47	m1_off	0	2.95	No	No	No	Yes	5	8
393	8x53	8x57	m1_off	0	2.95	No	No	Yes	No	8	8
394	8x55	8x56	m1_off	0	2.43	No	No	No	No	6	6
395	3x50	5x58	m1_off	0	2.06	No	Yes	No	No	9	9
396	3x51	5x60	m1_off	0	2.06	No	Yes	No	No	8	7
397	5x44	Lig	m1_off	0	2.01	No	No	Yes	Yes	7	0
398	1x47	2x54	m1_off	0	1.84	No	No	No	No	7	8
399	4x68	4x69	m1_off	0	1.84	No	No	No	No	4	4
400	1x36	1x39	m1_off	0	1.82	No	No	No	Yes	5	6
401	3x30	4x58	m1_off	0	1.79	No	No	No	No	8	6
402	5x37	6x58	m1_off	0	1.78	No	No	No	No	5	5
403	1x40	1x44	m1_off	0	1.71	No	No	No	No	5	5
404	6x57	E3.C394	m1_off	0	1.71	No	No	No	No	6	8
405	5x37	5x38	m1_off	0	1.69	No	No	No	No	5	5
406	1x38	1x39	m1_off	0	1.57	No	No	No	Yes	4	6
407	7x30	7x31	m1_off	0	1.57	No	No	No	No	6	3
408	6x53	6x57	m1_off	0	1.54	No	No	No	No	7	6
409	1x32	2x66	m1_off	0	1.52	No	No	No	No	4	6
410	6x29	6x32	m1_off	0	1.44	No	No	No	No	7	8
411	4x68	E2.E170	m1_off	0	1.43	No	No	No	No	4	4
412	5x65	5x66	m1_off	0	1.41	No	No	No	No	8	7
413	6x27	6x31	m1_off	0	1.41	No	No	No	No	5	7
414	8x47	8x48	m1_off	0	1.4	No	No	No	No	9	5
415	6x31	6x35	m1_off	0	1.24	No	No	No	No	7	7

Orange: nodes, hubs and links specific of m1_off_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m1_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	m1_off_allo Avg Int. Strength	m1_off Avg Int. Strength	m1_off_allo Num Of Links	m1_off Num Of Links	ConSurf
1	1x31	m1_off_allo	13.51	5.035	4	2	6
2	1x52	m1_off_allo	6.445	7.75667	4	3	8
3	2x51	m1_off_allo	3.2075	2.75	4	1	8
4	2x63	m1_off_allo	7.5	7.24	4	2	7
5	3x39	m1_off_allo	7.46167	3	6	1	9
6	3x49	m1_off_allo	9.3425	9.44	4	3	9
7	4x64	m1_off_allo	8.758	8.02667	5	3	7
8	E2.Q177	m1_off_allo	7.3775	4.13	4	3	4
9	E2x50	m1_off_allo	6.955	6.34667	4	3	9
10	5x48	m1_off_allo	5.09	5.3	4	2	7
11	7x39	m1_off_allo	7.838	8.49	5	1	8
12	7x45	m1_off_allo	6.73	5.79333	6	3	9
13	7x49	m1_off_allo	6.3425	7.58	4	2	9
14	8x51	m1_off_allo	4.04	1.24	4	1	9
15	8x57	m1_off_allo	3.232	4.33	5	2	8
16	Allo1	m1_off_allo	71.2819	0	16	0	0
17	1x50	Shared	6.3225	6.8	4	4	9
18	2x42	Shared	5.2475	6.445	4	4	8
19	2x50	Shared	9.8925	6.9275	4	4	9
20	2x53	Shared	6.35	5.42	4	5	8
21	2x60	Shared	8.35	9.5175	5	4	7
22	E1x50	Shared	6.95143	6.26571	7	7	9
23	3x33	Shared	9.21	10.688	4	5	8
24	3x37	Shared	6.59	5.698	5	5	8
25	3x52	Shared	6.5525	7.3275	4	4	7
26	I2x53	Shared	8.0675	7.006	4	5	9
27	I2x57	Shared	7.39833	7.968	6	5	8
28	4x50	Shared	4.735	5.5925	6	4	9
29	E2.R171	Shared	10.735	9.2625	4	4	7
30	E2x52	Shared	7.482	6.158	5	5	7
31	E2.F182	Shared	8.9025	6.6275	4	4	6
32	E2.L183	Shared	6.27	6.56	4	4	7
33	5x41	Shared	6.4575	5.9725	4	4	7
34	5x47	Shared	9.45167	10.8025	6	4	9
35	6x44	Shared	9.675	7.656	4	5	9
36	6x48	Shared	9.905	8.51625	8	8	8
37	7x34	Shared	11.05	7.41	4	4	7
38	7x38	Shared	9.948	10.13	5	6	7
39	7x42	Shared	6.515	7.36429	6	7	8
40	8x50	Shared	8.344	7.965	5	4	9
41	8x54	Shared	6.616	6.6925	5	4	9
42	Lig	Shared	9.986	8.67214	10	14	0
43	NT.K20	m1_off	0	4.525	0	4	5
44	1x39	m1_off	6.82333	5.7175	3	4	6
45	1x60	m1_off	9.23333	7.53	3	4	8
46	2x57	m1_off	5.85	6.25	2	4	8
47	3x28	m1_off	9.91	7.652	2	5	7
48	3x32	m1_off	11	7.7625	3	4	9
49	3x50	m1_off	7.68667	5.585	3	4	9
50	3x51	m1_off	7.42	6.16	3	6	8
51	3x56	m1_off	3.865	5.88	2	4	7
52	4x57	m1_off	8.28667	7.826	3	5	8
53	4x61	m1_off	5.495	4.0725	2	4	7
54	5x68	m1_off	2.67	5.7	3	5	8
55	6x47	m1_off	6.02	4.215	3	4	8
56	E3.V395	m1_off	5.96667	5.975	3	4	6

Orange: nodes, hubs and links specific of m1_off_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m1_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	m1_off_allo Recurrence	m1_off Recurrence	m1_off_allo Hub1?	m1_off Hub1?	m1_off_allo Hub2?	m1_off Hub2?	ConSurf1	ConSurf2
1	1x39	2x57	m1_off_allo	15.3914	0	No	Yes	No	Yes	6	8
2	1x50	7x50	m1_off_allo	48.1644	2.39513	Yes	Yes	No	No	9	9
3	1x49	7x50	m1_off_allo	46.7888	1.19895	No	No	No	No	9	9
4	1x49	1x52	m1_off_allo	42.6116	0	No	No	Yes	No	9	8
5	1x52	8x54	m1_off_allo	26.6516	3.57746	Yes	No	Yes	Yes	8	9
6	8x50	8x54	m1_off_allo	14.3711	0	Yes	Yes	Yes	Yes	9	9
7	6x47	7x40	m1_off_allo	17.5155	8.6363	No	Yes	No	No	8	8
8	7x45	7x49	m1_off_allo	49.9958	0	Yes	No	Yes	No	9	9
9	7x49	7x53	m1_off_allo	100	0	Yes	No	No	No	9	9
10	2x46	7x53	m1_off_allo	97.5121	0	No	No	No	No	9	9
11	2x46	3x42	m1_off_allo	96.2076	0	No	No	No	No	9	8
12	2x45	3x42	m1_off_allo	85.3696	0	No	No	No	No	9	8
13	2x45	4x46	m1_off_allo	85.3362	0	No	No	No	No	9	9
14	2x42	4x46	m1_off_allo	83.9396	5.81753	Yes	Yes	No	No	8	9
15	3x49	I2x57	m1_off_allo	50.6523	0.274124	Yes	No	Yes	Yes	9	8
16	1x52	8x57	m1_off_allo	14.4088	0	Yes	No	Yes	No	8	8
17	2x39	I2x57	m1_off_allo	28.1276	2.61664	No	No	Yes	Yes	8	8
18	2x39	3x50	m1_off_allo	24.7115	0	No	No	No	Yes	8	9
19	3x39	6x48	m1_off_allo	57.1249	0	Yes	No	Yes	Yes	9	8
20	2x60	Allo1	m1_off_allo	13.054	0	Yes	Yes	Yes	No	7	0
21	2x63	Allo1	m1_off_allo	25.5896	0	Yes	No	Yes	No	7	0
22	Allo1	E2x51	m1_off_allo	22.671	0	Yes	No	No	No	0	4
23	E2.V173	E2x51	m1_off_allo	20.8772	9.94601	No	No	No	No	4	4
24	E2.R171	E2.V173	m1_off_allo	19.0207	8.30126	Yes	Yes	No	No	7	4
25	4x65	E2.R171	m1_off_allo	13.3718	3.33103	No	No	Yes	Yes	7	7
26	4x64	Allo1	m1_off_allo	10.2316	0	Yes	No	Yes	No	7	0
27	3x37	4x53	m1_off_allo	15.9684	8.56985	Yes	Yes	No	No	8	8
28	5x47	6x48	m1_off_allo	32.0246	4.99792	Yes	Yes	Yes	Yes	9	8
29	5x47	5x51	m1_off_allo	21.6968	3.547	Yes	Yes	No	No	9	7
30	5x51	5x54	m1_off_allo	17.4235	0	No	No	No	No	7	9
31	5x47	6x52	m1_off_allo	13.146	5.76215	Yes	Yes	No	No	9	8
32	3x51	3x55	m1_off_allo	12.6401	4.63242	No	Yes	No	No	8	8
33	5x61	5x65	m1_off_allo	14.3335	0	No	No	No	No	9	8
34	3x54	5x65	m1_off_allo	12.5606	0	No	No	No	No	8	8
35	3x54	5x68	m1_off_allo	10.7794	8.48124	No	No	No	Yes	8	8
36	3x55	5x64	m1_off_allo	10.8588	3.27011	No	No	No	No	8	7
37	3x34	4x53	m1_off_allo	12.8408	0	No	No	No	No	8	8
38	3x34	4x58	m1_off_allo	11.2644	0	No	No	No	No	8	6
39	4x65	4x66	m1_off_allo	11.5111	1.66967	No	No	No	No	7	5
40	5x47	5x48	m1_off_allo	19.5643	0	Yes	Yes	Yes	No	9	7
41	5x41	5x45	m1_off_allo	10.9508	9.26762	Yes	Yes	No	No	7	6
42	7x45	7x48	m1_off_allo	11.6324	0	Yes	No	No	No	9	6
43	3x44	5x54	m1_off_allo	13.1167	0	No	No	No	No	7	9
44	2x50	3x39	m1_off_allo	26.7394	0	Yes	Yes	Yes	No	9	9
45	2x50	7x49	m1_off_allo	20.5051	4.77087	Yes	Yes	Yes	No	9	9
46	3x39	7x49	m1_off_allo	38.6603	0	Yes	No	Yes	No	9	9
47	6x48	7x45	m1_off_allo	37.6568	0.949744	Yes	Yes	Yes	No	8	9
48	7x38	7x42	m1_off_allo	16.2025	7.91084	Yes	Yes	Yes	Yes	7	8
49	7x38	Allo1	m1_off_allo	57.5263	0	Yes	Yes	Yes	No	7	0
50	2x60	7x42	Shared	14.9314	32.1113	Yes	Yes	Yes	Yes	7	8
51	2x57	7x42	Shared	17.5573	15.5309	No	Yes	Yes	Yes	8	8
52	2x53	7x42	Shared	29.5074	57.4692	Yes	Yes	Yes	Yes	8	8
53	2x53	7x46	Shared	30.9124	50.9622	Yes	Yes	No	No	8	9
54	2x50	7x46	Shared	23.7749	50.0208	Yes	Yes	No	No	9	9
55	1x50	2x50	Shared	58.8685	43.2757	Yes	Yes	Yes	Yes	9	9
56	2x42	3x49	Shared	78.2405	14.4815	Yes	Yes	Yes	No	8	9
57	2x38	I2x57	Shared	23.1519	39.7425	No	No	Yes	Yes	7	8
58	2x38	4x39	Shared	19.6814	34.3458	No	No	No	No	7	5
59	2x41	4x39	Shared	10.8588	25.776	No	No	No	No	7	5
60	7x38	Lig	Shared	56.5814	24.5383	Yes	Yes	Yes	Yes	7	0
61	6x48	Lig	Shared	87.0421	65.9255	Yes	Yes	Yes	Yes	8	0
62	2x63	E1x50	Shared	20.133	18.0867	Yes	No	Yes	Yes	7	9
63	3x28	E1x50	Shared	11.486	25.848	No	Yes	Yes	Yes	7	9
64	3x33	Lig	Shared	20.204	14.4344	Yes	Yes	Yes	Yes	8	0
65	3x33	E2x52	Shared	15.613	13.5899	Yes	Yes	Yes	Yes	8	7
66	3x37	Lig	Shared	23.9463	48.0881	Yes	Yes	Yes	Yes	8	0
67	6x52	Lig	Shared	13.4053	11.9673	No	No	Yes	Yes	8	0
68	3x49	I2x53	Shared	24.5819	17.0899	Yes	No	Yes	Yes	9	9
69	3x52	I2x53	Shared	24.8746	78.3525	Yes	Yes	Yes	Yes	7	9
70	3x51	3x52	Shared	16.1356	42.0352	No	Yes	Yes	Yes	8	7
71	3x50	5x61	Shared	16.098	10.7102	No	Yes	No	No	9	9
72	5x45	5x48	Shared	13.1167	10.7933	No	No	Yes	No	6	7
73	2x64	NT.K20	m1_off	0	27.7918	No	No	No	Yes	7	5
74	1x32	NT.K20	m1_off	0	21.57	No	No	No	Yes	4	5
75	1x32	2x65	m1_off	0	13.3712	No	No	No	No	4	6
76	2x61	2x65	m1_off	4.43636	10.0595	No	No	No	No	8	6
77	2x60	2x64	m1_off	7.23783	30.9317	Yes	Yes	No	No	7	7
78	1x50	2x47	m1_off	1.63071	39.2995	Yes	Yes	No	No	9	9
79	1x53	2x47	m1_off	0	38.2916	No	No	No	No	9	9
80	1x53	8x54	m1_off	1.59308	32.1971	No	No	Yes	Yes	9	9
81	1x56	8x54	m1_off	1.63071	27.1189	No	No	Yes	Yes	9	9
82	1x56	8x50	m1_off	0	26.0446	No	No	Yes	Yes	9	9
83	8x50	I1x50	m1_off	6.4852	16.2398	Yes	Yes	No	No	9	9
84	1x60	I1x50	m1_off	3.24887	15.1876	No	Yes	No	No	8	9
85	2x60	7x38	m1_off	4.82522	27.6866	Yes	Yes	Yes	Yes	7	7
86	3x37	3x40	m1_off	1.63071	53.709	Yes	Yes	No	No	8	9
87	3x40	5x50	m1_off	0	100	No	No	No	No	9	9
88	3x44	5x50	m1_off	4.40291	96.669	No	No	No	No	7	9
89	3x44	5x53	m1_off	6.59391	95.5531	No	No	No	No	7	7
90	5x53	5x57	m1_off	0	94.4372	No	No	No	No	7	8
91	3x48	5x57	m1_off	1.82305	40.1052	No	No	No	No	7	8
92	3x48	3x52	m1_off	3.60846	38.8398	No	No	Yes	Yes	7	7
93	I2x53	I2x57	m1_off	1.94012	47.6727	Yes	Yes	Yes	Yes	9	8
94	1x57	2x41	m1_off	5.43987	22.9074	No	No	No	No	8	7
95	1x57	2x44	m1_off	3.65028	11.6129	No	No	No	No	8	7
96	7x42	Lig	m1_off	0	79.7951	Yes	Yes	Yes	Yes	8	0
97	3x40	6x48	m1_off	0	48.7055	No	No	Yes	Yes	9	8
98	3x51	5x57	m1_off	1.85232	53.3739	No	Yes	No	No	8	8
99	2x60	3x28	m1_off	0	30.9234	Yes	Yes	No	Yes	7	7
100	2x63	E2.Q177	m1_off	0.271785	16.4696	Yes	No	Yes	No	7	4
101	E2.L174	E2.Q177	m1_off	0.0710821	13.2189	No	No	Yes	No	3	4
102	E2.L174	E2x51	m1_off	0	11.5852	No	No	No	No	3	4
103	3x30	4x61	m1_off	0	19.1666	No	No	No	Yes	8	7
104	3x30	4x58	m1_off	0	11.9147	No	No	No	No	8	6
105	6x44	6x48	m1_off	1.6558	14.1132	Yes	Yes	Yes	Yes	9	8
106	3x43	6x44	m1_off	1.53454	14.7307	No	No	Yes	Yes	8	9
107	3x43	6x41	m1_off	0	14.4206	No	No	No	No	8	7
108	6x37	6x41	m1_off	5.46496	13.7782	No	No	No	No	9	7
109	3x50	6x37	m1_off	7.19602	13.1054	No	Yes	No	No	9	9
110	E2.F182	E2x52	m1_off	2.88928	14.3292	Yes	Yes	Yes	Yes	6	7
111	4x64	E2.F182	m1_off	3.21542	15.8798	Yes	No	Yes	Yes	7	6
112	6x51	7x34	m1_off	8.69711	18.61	No	No	Yes	Yes	8	7
113	5x48	6x52	m1_off	0	12.3134	Yes	No	No	No	7	8
114	6x47	6x48	m1_off	9.21977	11.1145	No	Yes	Yes	Yes	8	8
115	4x57	4x61	m1_off	0	11.9396	No	Yes	No	Yes	8	7
116	6x51	Lig	m1_off	9.16541	14.0966	No	No	Yes	Yes	8	0

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	2x56	Shared	7.74	7.74	1	1	2	2
2x53	7x42	Shared	4.84	4.84	1	1	2	1
2x56	3x32	Shared	11.78	11.78	1	1	2	1
2x56	7x42	Shared	3.82	3.82	1	1	2	1
2x57	7x42	Shared	13.17	7.18	0	0	2	1
2x60	7x38	Shared	19.86	12.91	1	1	2	1
2x60	7x42	Shared	7.94	5.96	1	1	2	1
3x32	7x38	m1_off	4.6	0	1	1	1	1
3x32	7x42	Shared	10.34	10.34	1	1	1	1
3x32	Lig	Shared	4.33	10.88	1	1	1	0
3x33	4x57	Shared	15.43	11.58	1	1	1	1
3x33	4x61	Shared	3.63	3.63	1	1	1	2
3x33	E2x52	Shared	8.46	9.67	1	1	1	2
3x33	7x38	m1_off	4.96	0	1	1	1	1
3x33	Lig	Shared	20.96	11.96	1	1	1	0
3x36	6x48	Shared	6.18	4.94	1	1	1	1
3x36	Lig	Shared	9.59	8.75	1	1	1	0
3x37	3x40	Shared	4.3	4.3	1	0	1	2
3x37	4x53	Shared	5.78	5.78	1	0	1	2
3x37	4x57	Shared	8.76	9.86	1	0	1	1
3x37	5x461	m1_off	4.55	0	1	0	1	1
3x37	Lig	Shared	5.1	4.85	1	0	1	0
3x40	6x48	m1_off	3.68	0	0	0	2	1
4x57	4x61	m1_off	3.52	0	1	0	1	2
4x57	Lig	m1_off	8	0	1	0	1	0
4x61	E2x52	Shared	5.89	7.36	1	1	2	2
E2.L183	E2x52	Shared	7.14	8.56	1	1	2	2
5x40	E2.L183	m1_off	7.37	0	0	0	2	2
5x43	E2.L183	Shared	4.42	7.37	0	0	1	2
5x43	Lig	m1_off	4.71	0	0	0	1	0
5x461	Lig	Shared	4.02	8.04	1	0	1	0
5x47	6x44	Shared	5.36	4.29	1	1	2	2
5x47	6x48	Shared	7.02	6.01	1	1	2	1
5x47	6x52	Shared	22.96	25.37	1	1	2	1
5x48	6x52	m1_off	5.81	0	0	0	2	1
6x44	6x48	Shared	17.04	21.05	1	1	2	1
6x44	7x45	Shared	3.62	4.83	1	1	2	2
6x47	6x48	Shared	3.64	4.85	1	1	2	1
6x47	7x45	Shared	5.85	7.31	1	1	2	2
6x48	7x41	Shared	11.75	14.37	1	1	1	1
6x48	7x45	Shared	7.91	7.91	1	1	1	2
6x48	Lig	Shared	10.91	14.11	1	1	1	0
6x51	7x34	Shared	6.75	6.75	1	1	1	2
6x51	7x38	Shared	7.94	6.95	1	1	1	1
6x51	Lig	Shared	14.22	11.96	1	1	1	0
6x52	Lig	Shared	10.52	11.01	0	0	1	0
7x38	7x42	Shared	6.95	6.95	1	1	1	1
7x38	Lig	Shared	16.47	13.67	1	1	1	0
7x41	Lig	Shared	6.08	4.63	1	1	1	0
7x42	Lig	m1_off	4.49	0	1	1	1	0
4x56	4x57	Shared	3.42	3.42	0	0	2	1
3x41	4x53	m1_off	3.07	0	0	0	2	2
5x44	Lig	m1_off	2.01	0	0	0	1	0
2x60	Allo1	m1_off_allo	0	9.26	1	1	2	2
3x37	3x41	m1_off_allo	0	8.16	1	0	1	2
3x39	6x48	m1_off_allo	0	6	0	1	2	1
3x39	7x45	m1_off_allo	0	12.05	0	1	2	2
5x47	5x48	m1_off_allo	0	9.28	1	1	2	2
7x34	Allo1	m1_off_allo	0	20.23	1	1	2	2
7x38	Allo1	m1_off_allo	0	9.26	1	1	1	2
Allo1	Allo1	m1_off_allo	0	466.88	0	1	2	2
5x40	5x43	m1_off_allo	0	3.14	0	0	2	1
6x52	6x55	m1_off_allo	0	2.96	0	0	1	2
5x44	5x48	m1_off_allo	0	2.67	0	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	m1_off_allo	6WJC-M₁-Atropine-Muscarinic toxin 7
	m1_off	5CXV-M₁-Tiotropium

Network Difference
Value	m1_off_allo	m1_off
I_min	3.52	3.5
Number of Linked Nodes	267	265
Number of Specific Nodes	11 (4.12%)	9 (3.40%)
Number of Shared Nodes	256 (95.88%)	256 (96.60%)
Number of Links	308	303
Number of Specific Links	112 (36.36%)	107 (35.31%)
Number of Shared Links	196 (63.64%)	196 (64.69%)
Number of Hubs	42	40
Number of Specific Hubs	16 (38.10%)	14 (35.00%)
Number of Shared Hubs	26 (61.90%)	26 (65.00%)
Average % Shared Neighbours (Jaccard)	49.63
Average % Shared Neighbours (Otsuka)	59.01
Average % Shared Neighbours (Overlap Coefficient)	68.17
Average % Shared Cliques (k3-6)	57.35
Graphlets Similarity	0.675717

Paths Difference
Value	m1_off_allo	m1_off
Number Of Nodes in MetaPath	69	66
Specific Nodes in MetaPath	32 (46.38%)	29 (43.94%)
Shared Nodes in MetaPath	256 (95.88%)	256 (95.88%)
Number Of Links MetaPath	72	67
Specific Links in MetaPath	49 (68.06%)	44 (65.67%)
Shared Links in MetaPath	196 (63.64%)	196 (63.64%)
Number of Shortest Paths	57611	73816
Length Of Smallest Path	3	3
Average Path Length	13.3193	14.8546
Length of Longest Path	32	34
Minimum Path Strength	1.2	1.32
Average Path Strength	7.49949	6.33489
Maximum Path Strength	21.325	18.1467
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.954644	0.923091
Maximum Path Correlation	1	0.99
Minimum % Of Corr. Nodes	4.54545	3.57143
Average % Of Corr. Nodes	62.478	44.5287
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	48.7939	44.5144
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download m1_off_ortoallo.zip<

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