psnGPCR

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Orange: nodes, hubs and links specific of m3_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m3_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	m3_off Int. Strength	m3_on Int. Strength	m3_off Hub1?	m3_on Hub1?	m3_off Hub2?	m3_on Hub2?	ConSurf1	ConSurf2
1	1x34	1x38	m3_off	100	0	No	No	No	No	5	5
2	1x39	1x40	m3_off	100	0	Yes	No	No	No	8	7
3	1x50	2x47	m3_off	100	0	No	No	No	No	9	9
4	1x53	7x53	m3_off	100	0	No	No	Yes	Yes	9	9
5	8x53	I1x50	m3_off	100	0	Yes	No	Yes	Yes	9	9
6	2x39	3x49	m3_off	100	0	No	No	Yes	No	9	9
7	2x39	3x50	m3_off	100	0	No	No	No	No	9	9
8	2x39	I2x57	m3_off	100	0	No	No	Yes	Yes	9	9
9	2x43	7x53	m3_off	100	0	No	No	Yes	Yes	9	9
10	2x45	4x50	m3_off	100	0	No	No	Yes	No	9	9
11	2x46	3x39	m3_off	100	0	No	No	No	No	9	9
12	2x46	3x42	m3_off	100	0	No	No	No	No	9	9
13	2x54	2x57	m3_off	100	0	No	No	Yes	Yes	9	9
14	2x59	E1x50	m3_off	100	0	No	No	Yes	Yes	8	9
15	2x60	7x35	m3_off	100	0	Yes	No	No	No	8	6
16	2x60	7x39	m3_off	100	0	Yes	No	Yes	Yes	8	8
17	2x60	7x42	m3_off	100	0	Yes	No	Yes	Yes	8	9
18	2x61	7x39	m3_off	100	0	Yes	No	Yes	Yes	8	8
19	2x62	2x66	m3_off	100	0	No	No	No	No	6	7
20	2x63	7x31	m3_off	100	0	No	No	No	No	7	2
21	3x24	E1x50	m3_off	100	0	No	No	Yes	Yes	7	9
22	E1x50	E2x50	m3_off	100	0	Yes	Yes	No	No	9	9
23	3x23	3x27	m3_off	100	0	No	No	No	No	5	6
24	3x26	4x65	m3_off	100	0	No	No	No	No	9	8
25	3x28	3x29	m3_off	100	0	Yes	Yes	Yes	No	7	8
26	3x28	3x32	m3_off	100	0	Yes	Yes	Yes	No	7	9
27	3x29	E2x50	m3_off	100	0	Yes	No	No	No	8	9
28	3x29	E2x52	m3_off	100	0	Yes	No	Yes	Yes	8	8
29	3x30	4x62	m3_off	100	0	No	No	No	No	8	8
30	3x32	7x38	m3_off	100	0	Yes	No	Yes	No	9	7
31	3x33	7x38	m3_off	100	0	Yes	No	Yes	No	9	7
32	3x40	5x50	m3_off	100	0	No	No	No	No	9	9
33	3x41	4x49	m3_off	100	0	No	No	No	No	8	9
34	3x41	4x52	m3_off	100	0	No	No	No	No	8	7
35	3x43	6x44	m3_off	100	0	No	No	Yes	Yes	9	9
36	3x48	3x52	m3_off	100	0	No	No	No	No	8	7
37	3x49	3x53	m3_off	100	0	Yes	No	Yes	No	9	9
38	3x53	I2x57	m3_off	100	0	Yes	No	Yes	Yes	9	9
39	4x38	4x41	m3_off	100	0	No	No	No	No	9	8
40	4x64	4x67	m3_off	100	0	No	No	No	No	7	5
41	4x64	4x68	m3_off	100	0	No	No	No	No	7	7
42	4x65	4x66	m3_off	100	0	No	No	No	No	8	6
43	4x68	E2	m3_off	100	0	No	No	Yes	Yes	7	6
44	5x36	5x37	m3_off	100	0	No	Yes	No	No	7	6
45	5x40	6x55	m3_off	100	0	No	No	No	No	9	8
46	5x41	5x45	m3_off	100	0	No	No	No	No	7	7
47	5x42	5x45	m3_off	100	0	No	No	No	No	7	7
48	5x51	6x45	m3_off	100	0	No	No	No	No	8	8
49	5x54	6x41	m3_off	100	0	No	No	No	No	9	8
50	5x58	5x59	m3_off	100	0	No	Yes	Yes	No	9	5
51	5x58	6x38	m3_off	100	0	No	Yes	No	No	9	9
52	5x59	5x62	m3_off	100	0	Yes	No	No	Yes	5	8
53	5x64	5x67	m3_off	100	0	No	No	No	No	8	6
54	5x66	6x27	m3_off	100	0	No	Yes	No	No	7	6
55	5x66	6x31	m3_off	100	0	No	Yes	No	No	7	7
56	6x27	6x30	m3_off	100	0	No	No	No	No	6	9
57	6x27	6x31	m3_off	100	0	No	No	No	No	6	7
58	6x28	6x29	m3_off	100	0	No	No	No	No	7	7
59	6x40	7x49	m3_off	100	0	No	Yes	Yes	No	9	9
60	6x47	7x40	m3_off	100	0	Yes	No	No	No	9	9
61	6x50	7x40	m3_off	100	0	No	No	No	No	9	9
62	6x51	7x34	m3_off	100	0	No	No	Yes	No	9	5
63	6x51	7x38	m3_off	100	0	No	No	Yes	No	9	7
64	6x54	7x34	m3_off	100	0	No	No	Yes	No	7	5
65	6x57	E3	m3_off	100	0	No	No	Yes	Yes	6	6
66	7x34	E3	m3_off	100	0	Yes	No	Yes	Yes	5	6
67	7x49	7x53	m3_off	100	0	Yes	No	Yes	Yes	9	9
68	8x50	8x54	m3_off	100	0	Yes	No	No	Yes	9	9
69	5x65	6x31	m3_off	100	0	No	No	No	No	9	7
70	3x39	7x45	m3_off	100	0	No	No	Yes	Yes	9	9
71	2x40	2x43	m3_off	33.3333	0	Yes	Yes	No	No	9	9
72	5x43	Lig	m3_off	66.6667	0	No	No	Yes	Yes	9	0
73	6x39	7x52	m3_off	66.6667	0	No	No	No	No	9	9
74	5x54	6x44	m3_off	33.3333	0	No	No	Yes	Yes	9	9
75	5x53	5x57	m3_off	0	0	No	No	No	No	8	8
76	2x42	4x42	m3_off	0	0	Yes	Yes	No	No	8	9
77	1x55	1x59	m3_off	33.3333	0	No	No	No	No	5	8
78	3x35	4x50	m3_off	0	0	No	No	Yes	No	8	9
79	2x51	2x55	m3_off	0	0	No	No	No	No	8	7
80	5x55	5x59	m3_off	0	0	No	No	Yes	No	7	5
81	2x41	4x46	m3_off	0	0	Yes	No	Yes	No	8	9
82	6x29	6x32	m3_off	33.3333	0	No	No	No	No	7	9
83	2x551	2x59	m3_off	0	0	Yes	No	No	No	6	8
84	5x44	Lig	m3_off	0	0	No	No	Yes	Yes	9	0
85	1x52	8x57	m3_off	0	0	No	No	No	No	8	8
86	3x50	6x33	m3_off	0	0	No	No	No	No	9	9
87	6x37	6x41	m3_off	33.3333	0	No	No	No	No	9	8
88	6x29	6x30	m3_off	33.3333	0	No	No	No	No	7	9
89	5x65	6x34	m3_off	33.3333	0	No	No	No	No	9	9
90	1x28	1x30	m3_off	33.3333	0	No	No	No	No	4	4
91	2x41	4x43	m3_off	0	0	Yes	No	No	No	8	4
92	6x32	8x47	m3_off	33.3333	0	No	No	No	No	9	9
93	7x54	8x54	m3_off	0	0	No	No	No	Yes	9	9
94	6x39	7x56	m3_off	0	0	No	No	No	No	9	9
95	3x34	4x57	m3_off	0	0	No	No	Yes	Yes	8	9
96	8x52	8x53	m3_off	0	0	No	No	Yes	No	6	9
97	1x35	1x39	m3_off	0	0	No	No	Yes	No	8	8
98	6x46	6x47	m3_off	0	0	No	No	Yes	No	6	9
99	2x61	2x65	m3_off	0	0	Yes	No	No	No	8	8
100	4x39	4x40	m3_off	33.3333	0	No	No	No	No	7	6
101	3x54	5x61	m3_off	0	0	No	No	No	No	8	9
102	7x32	7x36	m3_off	0	0	No	No	No	No	4	7
103	6x42	6x46	m3_off	33.3333	0	No	No	No	No	6	6
104	1x33	1x37	m3_off	33.3333	0	No	No	No	No	6	5
105	1x31	1x34	m3_off	0	0	No	No	No	No	7	5
106	1x32	2x65	m3_off	0	0	No	No	No	No	6	8
107	7x54	8x51	m3_off	0	0	No	No	Yes	No	9	9
108	4x69	E2	m3_off	0	0	No	No	Yes	Yes	6	6
109	8x59	8x60	m3_off	0	0	No	No	No	No	0	0
110	4x40	4x44	m3_off	0	0	No	No	No	No	6	5
111	8x56	8x57	m3_off	0	0	No	No	No	No	6	8
112	3x21	E1x50	m3_off	0	0	No	No	Yes	Yes	9	9
113	4x54	4x55	m3_off	0	0	No	No	No	No	5	6
114	7x55	8x51	m3_off	0	0	No	No	Yes	No	8	9
115	1x39	2x61	Shared	100	100	Yes	No	Yes	No	8	8
116	1x39	7x39	Shared	100	100	Yes	No	Yes	Yes	8	8
117	1x41	1x45	Shared	100	0	No	No	No	No	5	6
118	1x42	7x39	Shared	100	100	No	No	Yes	Yes	7	8
119	1x46	2x57	Shared	100	100	No	No	Yes	Yes	9	9
120	1x46	7x47	Shared	100	100	No	No	No	No	9	8
121	1x47	2x55	Shared	100	0	No	No	No	No	7	7
122	1x49	7x50	Shared	100	0	No	No	No	No	9	9
123	1x50	2x50	Shared	100	100	No	No	Yes	Yes	9	9
124	1x50	7x50	Shared	100	100	No	No	No	No	9	9
125	1x51	2x51	Shared	100	50	No	No	No	No	7	8
126	1x52	8x54	Shared	100	100	No	No	No	Yes	8	9
127	1x53	2x47	Shared	100	0	No	No	No	No	9	9
128	1x54	2x44	Shared	100	50	No	No	No	No	7	8
129	1x55	8x57	Shared	100	0	No	No	No	No	5	8
130	1x56	8x53	Shared	100	100	No	No	Yes	No	9	9
131	1x57	1x58	Shared	100	100	Yes	Yes	No	No	9	6
132	1x57	I1x51	Shared	100	100	Yes	Yes	No	No	9	8
133	1x57	2x41	Shared	100	100	Yes	Yes	Yes	No	9	8
134	1x57	2x44	Shared	100	100	Yes	Yes	No	No	9	8
135	1x58	I1x51	Shared	100	100	No	No	No	No	6	8
136	1x60	I1x49	Shared	100	100	No	No	No	No	8	7
137	1x60	I1x50	Shared	100	100	No	No	Yes	Yes	8	9
138	1x60	8x53	Shared	100	100	No	No	Yes	No	8	9
139	I1x48	I1x51	Shared	100	100	No	No	No	No	8	8
140	8x49	I1x50	Shared	100	100	No	No	Yes	Yes	8	9
141	8x50	I1x50	Shared	100	100	Yes	No	Yes	Yes	9	9
142	2x37	2x40	Shared	100	100	No	No	Yes	Yes	8	9
143	2x38	I2x57	Shared	100	100	No	No	Yes	Yes	8	9
144	2x40	8x50	Shared	100	100	Yes	Yes	Yes	No	9	9
145	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	8
146	2x42	3x46	Shared	100	100	Yes	Yes	No	Yes	8	9
147	2x42	3x49	Shared	100	100	Yes	Yes	Yes	No	8	9
148	2x42	4x46	Shared	100	100	Yes	Yes	Yes	No	8	9
149	2x45	3x42	Shared	100	100	No	No	No	No	9	9
150	2x45	4x46	Shared	100	100	No	No	Yes	No	9	9
151	2x50	3x39	Shared	100	100	Yes	Yes	No	No	9	9
152	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
153	2x50	7x49	Shared	100	100	Yes	Yes	Yes	No	9	9
154	2x53	2x56	Shared	100	100	No	Yes	No	Yes	9	9
155	2x53	7x42	Shared	100	100	No	Yes	Yes	Yes	9	9
156	2x53	7x46	Shared	100	100	No	Yes	No	No	9	9
157	2x56	3x32	Shared	100	100	No	Yes	Yes	No	9	9
158	2x56	7x42	Shared	100	100	No	Yes	Yes	Yes	9	9
159	2x57	7x39	Shared	100	100	Yes	Yes	Yes	Yes	9	8
160	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	9	9
161	2x59	3x28	Shared	100	100	No	No	Yes	Yes	8	7
162	2x60	2x64	Shared	100	100	Yes	No	No	No	8	8
163	2x60	3x28	Shared	100	100	Yes	No	Yes	Yes	8	7
164	2x60	7x38	Shared	100	100	Yes	No	Yes	No	8	7
165	2x64	7x35	Shared	100	100	No	No	No	No	8	6
166	E1x50	E1x52	Shared	100	100	Yes	Yes	No	No	9	8
167	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	9
168	3x28	E1x50	Shared	100	100	Yes	Yes	Yes	Yes	7	9
169	3x22	E2	Shared	100	100	No	No	Yes	Yes	5	6
170	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
171	3x29	4x61	Shared	100	100	Yes	No	No	Yes	8	9
172	3x32	7x42	Shared	100	100	Yes	No	Yes	Yes	9	9
173	3x32	Lig	Shared	100	100	Yes	No	Yes	Yes	9	0
174	3x33	4x57	Shared	100	100	Yes	No	Yes	Yes	9	9
175	3x33	E2x52	Shared	100	100	Yes	No	Yes	Yes	9	8
176	3x33	Lig	Shared	100	100	Yes	No	Yes	Yes	9	0
177	3x36	Lig	Shared	100	100	No	No	Yes	Yes	9	0
178	3x37	4x53	Shared	100	100	Yes	Yes	No	No	9	9
179	3x37	4x57	Shared	100	100	Yes	Yes	Yes	Yes	9	9
180	3x37	Lig	Shared	100	100	Yes	Yes	Yes	Yes	9	0
181	3x38	4x50	Shared	100	100	No	No	Yes	No	9	9
182	3x38	4x53	Shared	100	0	No	No	No	No	9	9
183	3x40	6x44	Shared	100	100	No	No	Yes	Yes	9	9
184	3x44	5x50	Shared	100	100	No	No	No	No	9	9
185	3x47	5x54	Shared	100	0	No	No	No	No	9	9
186	3x48	5x57	Shared	100	100	No	No	No	No	8	8
187	3x49	I2x53	Shared	100	100	Yes	No	Yes	Yes	9	9
188	3x49	I2x57	Shared	100	100	Yes	No	Yes	Yes	9	9
189	3x51	3x52	Shared	100	100	Yes	Yes	No	No	9	7
190	3x51	3x55	Shared	100	100	Yes	Yes	No	No	9	8
191	3x51	5x60	Shared	100	100	Yes	Yes	No	No	9	8
192	3x51	5x61	Shared	100	50	Yes	Yes	No	No	9	9
193	3x52	I2x53	Shared	100	100	No	No	Yes	Yes	7	9
194	3x53	I2x53	Shared	100	100	Yes	No	Yes	Yes	9	9
195	I2x53	I2x57	Shared	100	100	Yes	Yes	Yes	Yes	9	9
196	4x48	4x52	Shared	100	100	No	No	No	No	6	7
197	4x54	4x58	Shared	100	50	No	No	No	No	5	7
198	4x57	E2	Shared	100	100	Yes	Yes	Yes	Yes	9	6
199	4x57	Lig	Shared	100	100	Yes	Yes	Yes	Yes	9	0
200	4x61	E2x52	Shared	100	100	No	Yes	Yes	Yes	9	8
201	4x62	4x63	Shared	100	0	No	No	No	No	8	7
202	4x64	E2	Shared	100	100	No	No	Yes	Yes	7	6
203	4x65	E2	Shared	100	100	No	No	Yes	Yes	8	6
204	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	6	6
205	E2	E2x51	Shared	100	100	Yes	Yes	No	No	6	4
206	E2	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	6	8
207	5x40	E2	Shared	100	100	No	No	Yes	Yes	9	6
208	5x36	5x38	Shared	100	100	No	Yes	No	No	7	5
209	5x36	5x39	Shared	100	100	No	Yes	No	No	7	8
210	5x41	6x56	Shared	100	100	No	No	No	No	7	7
211	5x41	6x59	Shared	100	100	No	No	No	Yes	7	8
212	5x461	Lig	Shared	100	100	No	No	Yes	Yes	9	0
213	5x47	5x48	Shared	100	100	Yes	Yes	No	Yes	9	8
214	5x47	5x51	Shared	100	100	Yes	Yes	No	No	9	8
215	5x47	6x44	Shared	100	100	Yes	Yes	Yes	Yes	9	9
216	5x47	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	9
217	5x47	6x49	Shared	100	50	Yes	Yes	No	Yes	9	8
218	5x47	6x52	Shared	100	100	Yes	Yes	No	Yes	9	9
219	5x48	6x52	Shared	100	100	No	Yes	No	Yes	8	9
220	5x49	5x50	Shared	100	0	No	No	No	No	7	9
221	5x56	5x60	Shared	100	0	No	No	No	No	6	8
222	6x36	7x56	Shared	100	0	No	No	No	No	9	9
223	6x40	7x53	Shared	100	100	No	Yes	Yes	Yes	9	9
224	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	9
225	6x44	7x45	Shared	100	100	Yes	Yes	Yes	Yes	9	9
226	6x47	6x48	Shared	100	100	Yes	No	Yes	Yes	9	9
227	6x47	7x45	Shared	100	100	Yes	No	Yes	Yes	9	9
228	6x48	7x41	Shared	100	100	Yes	Yes	No	No	9	9
229	6x48	7x45	Shared	100	100	Yes	Yes	Yes	Yes	9	9
230	6x48	Lig	Shared	100	100	Yes	Yes	Yes	Yes	9	0
231	6x49	6x50	Shared	100	0	No	Yes	No	No	8	9
232	6x51	Lig	Shared	100	100	No	No	Yes	Yes	9	0
233	6x52	Lig	Shared	100	100	No	Yes	Yes	Yes	9	0
234	6x54	E3	Shared	100	0	No	No	Yes	Yes	7	6
235	6x58	7x34	Shared	100	100	No	No	Yes	No	7	5
236	6x59	6x60	Shared	100	100	No	Yes	No	No	8	7
237	6x61	E3	Shared	100	100	No	No	Yes	Yes	8	6
238	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	6	6
239	7x30	E3	Shared	100	0	No	No	Yes	Yes	7	6
240	7x30	7x33	Shared	100	100	No	No	No	No	7	5
241	7x31	7x35	Shared	100	100	No	No	No	No	2	6
242	7x38	7x42	Shared	100	100	Yes	No	Yes	Yes	7	9
243	7x38	Lig	Shared	100	100	Yes	No	Yes	Yes	7	0
244	7x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	8	9
245	7x41	Lig	Shared	100	100	No	No	Yes	Yes	9	0
246	7x45	7x49	Shared	100	100	Yes	Yes	Yes	No	9	9
247	8x47	8x49	Shared	100	100	No	No	No	No	9	8
248	8x47	8x50	Shared	100	100	No	No	Yes	No	9	9
249	8x48	8x51	Shared	100	100	No	No	Yes	No	7	9
250	2x63	E2	Shared	100	100	No	No	Yes	Yes	7	6
251	3x26	E2	Shared	100	100	No	No	Yes	Yes	9	6
252	4x41	I2x56	Shared	66.6667	50	No	No	No	No	8	8
253	4x60	E2	Shared	66.6667	50	No	No	Yes	Yes	8	6
254	1x52	8x58	Shared	33.3333	0	No	No	No	No	8	8
255	1x45	7x47	Shared	33.3333	0	No	No	No	No	6	8
256	7x39	7x43	Shared	33.3333	100	Yes	Yes	No	No	8	8
257	5x58	6x41	Shared	33.3333	0	No	Yes	No	No	9	8
258	4x58	4x59	Shared	66.6667	0	No	No	No	No	7	9
259	5x39	E2	Shared	66.6667	100	No	No	Yes	Yes	8	6
260	3x53	I2x54	Shared	33.3333	100	Yes	No	No	No	9	8
261	6x49	6x53	Shared	0	0	No	Yes	No	No	8	8
262	7x51	7x55	Shared	0	100	No	No	No	No	7	8
263	2x551	3x31	Shared	33.3333	50	Yes	No	No	No	6	6
264	4x52	4x56	Shared	0	0	No	No	No	No	7	8
265	6x43	7x48	Shared	33.3333	0	No	No	No	No	8	7
266	3x37	3x41	Shared	0	50	Yes	Yes	No	No	9	8
267	3x34	4x54	Shared	33.3333	0	No	No	No	No	8	5
268	2x49	4x50	Shared	0	0	No	No	Yes	No	9	9
269	3x55	3x56	Shared	33.3333	100	No	No	No	No	8	8
270	3x56	I2x52	Shared	33.3333	100	No	No	No	No	8	7
271	3x30	4x61	Shared	33.3333	0	No	No	No	Yes	8	9
272	2x55	2x551	Shared	0	0	No	No	Yes	No	7	6
273	8x51	8x55	Shared	33.3333	50	Yes	No	No	No	9	7
274	2x52	2x551	Shared	33.3333	50	No	No	Yes	No	8	6
275	1x57	2x40	Shared	0	0	Yes	Yes	Yes	Yes	9	9
276	1x28	1x31	Shared	33.3333	100	No	No	No	No	4	7
277	4x46	4x47	Shared	66.6667	0	Yes	No	No	No	9	6
278	6x40	7x52	Shared	33.3333	100	No	Yes	No	No	9	9
279	1x43	2x57	Shared	0	50	No	No	Yes	Yes	8	9
280	1x43	2x58	Shared	0	0	No	No	No	No	8	9
281	7x32	7x33	Shared	0	0	No	No	No	No	4	5
282	2x41	4x39	Shared	33.3333	0	Yes	No	No	No	8	7
283	3x45	4x45	Shared	0	100	No	No	No	No	8	8
284	5x48	6x56	Shared	0	100	No	Yes	No	No	8	7
285	3x56	I2x50	Shared	0	0	No	No	No	No	8	9
286	1x38	1x42	Shared	0	0	No	No	No	No	5	7
287	6x32	6x35	Shared	33.3333	50	No	No	No	No	9	7
288	1x48	1x49	Shared	0	0	No	No	No	No	5	9
289	7x37	7x40	Shared	0	0	No	No	No	No	8	9
290	7x48	7x52	Shared	0	0	No	No	No	No	7	9
291	2x66	E1x49	Shared	0	100	No	No	No	No	7	4
292	1x54	2x48	Shared	0	0	No	No	No	No	7	6
293	4x51	4x55	Shared	0	0	No	No	No	No	4	6
294	4x38	4x40	Shared	0	100	No	No	No	No	9	6
295	3x54	5x64	Shared	0	100	No	No	No	No	8	8
296	1x29	1x30	Shared	0	0	No	No	No	No	5	4
297	1x36	2x65	Shared	0	0	No	No	No	No	7	8
298	2x66	E1x51	Shared	0	0	No	No	No	No	7	5
299	2x61	2x62	Shared	0	0	Yes	No	No	No	8	6
300	5x59	5x63	Shared	0	100	Yes	No	No	No	5	5
301	5x52	5x53	Shared	0	0	No	No	No	No	8	8
302	5x52	5x56	Shared	0	0	No	No	No	No	8	6
303	I2x51	I2x52	Shared	0	0	No	No	No	No	8	7
304	3x27	4x62	Shared	0	0	No	No	No	No	6	8
305	1x37	1x41	m3_on	0	100	No	No	No	No	5	5
306	1x53	8x54	m3_on	0	100	No	No	No	Yes	9	9
307	1x56	8x54	m3_on	0	100	No	No	No	Yes	9	9
308	8x49	I1x49	m3_on	0	100	No	No	No	No	8	7
309	2x40	I1x50	m3_on	0	100	Yes	Yes	Yes	Yes	9	9
310	2x39	2x40	m3_on	0	100	No	No	Yes	Yes	9	9
311	2x39	I2x54	m3_on	0	100	No	No	No	No	9	8
312	2x42	4x45	m3_on	0	100	Yes	Yes	No	No	8	8
313	2x46	3x43	m3_on	0	100	No	No	No	No	9	9
314	2x46	7x49	m3_on	0	100	No	No	Yes	No	9	9
315	2x56	3x28	m3_on	0	100	No	Yes	Yes	Yes	9	7
316	2x63	E1x50	m3_on	0	100	No	No	Yes	Yes	7	9
317	3x26	4x61	m3_on	0	100	No	No	No	Yes	9	9
318	3x26	4x62	m3_on	0	100	No	No	No	No	9	8
319	3x40	6x48	m3_on	0	100	No	No	Yes	Yes	9	9
320	3x43	7x53	m3_on	0	100	No	No	Yes	Yes	9	9
321	3x44	5x53	m3_on	0	100	No	No	No	No	9	8
322	3x46	3x50	m3_on	0	100	No	Yes	No	No	9	9
323	3x46	7x53	m3_on	0	100	No	Yes	Yes	Yes	9	9
324	3x48	5x53	m3_on	0	100	No	No	No	No	8	8
325	3x50	5x58	m3_on	0	100	No	No	No	Yes	9	9
326	3x50	7x53	m3_on	0	100	No	No	Yes	Yes	9	9
327	3x51	5x57	m3_on	0	100	Yes	Yes	No	No	9	8
328	3x55	5x64	m3_on	0	100	No	No	No	No	8	8
329	I2x54	I2x57	m3_on	0	100	No	No	Yes	Yes	8	9
330	4x56	4x57	m3_on	0	100	No	No	Yes	Yes	8	9
331	4x57	E2x52	m3_on	0	100	Yes	Yes	Yes	Yes	9	8
332	4x57	5x43	m3_on	0	100	Yes	Yes	No	No	9	9
333	4x67	4x68	m3_on	0	100	No	No	No	No	5	7
334	5x36	E2	m3_on	0	100	No	Yes	Yes	Yes	7	6
335	5x37	6x59	m3_on	0	100	No	No	No	Yes	6	8
336	5x40	6x59	m3_on	0	100	No	No	No	Yes	9	8
337	5x45	5x48	m3_on	0	100	No	No	No	Yes	7	8
338	5x55	6x41	m3_on	0	100	No	No	No	No	7	8
339	5x58	6x37	m3_on	0	100	No	Yes	No	No	9	9
340	5x58	6x40	m3_on	0	100	No	Yes	No	Yes	9	9
341	5x62	5x66	m3_on	0	100	No	Yes	No	Yes	8	7
342	5x66	6x30	m3_on	0	100	No	Yes	No	No	7	9
343	6x30	6x31	m3_on	0	100	No	No	No	No	9	7
344	6x35	6x36	m3_on	0	100	No	No	No	No	7	9
345	6x45	6x49	m3_on	0	100	No	No	No	Yes	8	8
346	6x47	7x43	m3_on	0	100	Yes	No	No	No	9	8
347	6x51	6x52	m3_on	0	100	No	No	No	Yes	9	9
348	6x51	6x55	m3_on	0	100	No	No	No	No	9	8
349	6x57	6x60	m3_on	0	100	No	No	No	No	6	7
350	6x58	E3	m3_on	0	100	No	No	Yes	Yes	7	6
351	7x42	Lig	m3_on	0	100	Yes	Yes	Yes	Yes	9	0
352	7x55	8x54	m3_on	0	100	No	No	No	Yes	8	9
353	8x48	8x52	m3_on	0	100	No	No	No	No	7	6
354	4x64	5x36	m3_on	0	100	No	No	No	Yes	7	7
355	8x55	8x59	m3_on	0	100	No	No	No	No	7	0
356	7x31	7x34	m3_on	0	50	No	No	Yes	No	2	5
357	2x52	3x35	m3_on	0	0	No	No	No	No	8	8
358	3x47	5x58	m3_on	0	50	No	No	No	Yes	9	9
359	5x68	5x72	m3_on	0	50	No	No	No	No	0	0
360	1x59	8x57	m3_on	0	50	No	No	No	No	8	8
361	1x30	1x31	m3_on	0	0	No	No	No	No	4	7
362	1x46	2x54	m3_on	0	0	No	No	No	No	9	9
363	5x68	5x69	m3_on	0	0	No	No	No	No	0	0
364	4x40	4x41	m3_on	0	50	No	No	No	No	6	8
365	2x53	3x35	m3_on	0	0	No	Yes	No	No	9	8
366	2x43	7x54	m3_on	0	0	No	No	No	No	9	9
367	3x42	4x49	m3_on	0	50	No	No	No	No	9	9
368	2x43	3x46	m3_on	0	0	No	No	No	Yes	9	9
369	5x65	5x66	m3_on	0	0	No	No	No	Yes	9	7
370	8x55	8x58	m3_on	0	50	No	No	No	No	7	8
371	5x44	5x48	m3_on	0	0	No	No	No	Yes	9	8
372	5x62	6x33	m3_on	0	0	No	Yes	No	No	8	9
373	1x40	1x43	m3_on	0	0	No	No	No	No	7	8
374	3x21	3x24	m3_on	0	0	No	No	No	No	9	7
375	4x55	4x59	m3_on	0	0	No	No	No	No	6	9
376	5x62	6x37	m3_on	0	0	No	Yes	No	No	8	9
377	6x54	7x37	m3_on	0	0	No	No	No	No	7	8
378	3x21	E1x52	m3_on	0	0	No	No	No	No	9	8
379	7x36	7x37	m3_on	0	0	No	No	No	No	7	8
380	2x38	4x42	m3_on	0	0	No	No	No	No	8	9
381	8x56	8x60	m3_on	0	0	No	No	No	No	6	0
382	1x34	1x37	m3_on	0	0	No	No	No	No	5	5
383	1x59	8x53	m3_on	0	0	No	No	Yes	No	8	9
384	4x63	4x66	m3_on	0	0	No	No	No	No	7	6
385	1x51	1x55	m3_on	0	0	No	No	No	No	7	5
386	6x36	6x40	m3_on	0	0	No	No	No	Yes	9	9
387	E1x49	E2	m3_on	0	0	No	No	Yes	Yes	4	6
388	2x65	2x66	m3_on	0	0	No	No	No	No	8	7
389	1x44	1x48	m3_on	0	0	No	No	No	No	7	5
390	3x23	4x65	m3_on	0	0	No	No	No	No	5	8
391	4x41	I2x57	m3_on	0	0	No	No	Yes	Yes	8	9
392	4x42	4x43	m3_on	0	0	No	No	No	No	9	4
393	4x68	4x69	m3_on	0	0	No	No	No	No	7	6
394	3x30	4x58	m3_on	0	0	No	No	No	No	8	7
395	1x33	1x36	m3_on	0	0	No	No	No	No	6	7
396	1x28	1x32	m3_on	0	0	No	No	No	No	4	6
397	4x56	5x46	m3_on	0	0	No	No	No	No	8	8
398	4x44	4x45	m3_on	0	0	No	No	No	No	5	8
399	6x35	6x39	m3_on	0	0	No	No	No	No	7	9
400	5x41	5x42	m3_on	0	0	No	No	No	No	7	7
401	8x52	8x56	m3_on	0	0	No	No	No	No	6	6
402	6x38	6x42	m3_on	0	0	No	No	No	No	9	6
403	5x66	5x69	m3_on	0	0	No	Yes	No	No	7	0
404	5x67	5x71	m3_on	0	0	No	No	No	No	6	0
405	5x62	6x34	m3_on	0	0	No	Yes	No	No	8	9
406	5x62	5x63	m3_on	0	0	No	Yes	No	No	8	5

Orange: nodes, hubs and links specific of m3_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m3_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	m3_off Avg Int. Strength	m3_on Avg Int. Strength	m3_off Num Of Links	m3_on Num Of Links	ConSurf
1	1x39	m3_off	0	0	4	2	8
2	2x41	m3_off	0	0	4	2	8
3	2x551	m3_off	0	0	4	3	6
4	2x60	m3_off	100	50	6	3	8
5	2x61	m3_off	0	0	4	2	8
6	3x29	m3_off	33.3333	0	4	1	8
7	3x32	m3_off	100	50	5	3	9
8	3x33	m3_off	66.6667	50	4	3	9
9	3x49	m3_off	100	50	5	3	9
10	3x53	m3_off	0	0	4	2	9
11	4x46	m3_off	0	0	4	3	9
12	4x50	m3_off	0	0	4	2	9
13	5x59	m3_off	0	0	4	1	5
14	6x47	m3_off	0	0	4	3	9
15	7x34	m3_off	100	0	4	2	5
16	7x38	m3_off	100	100	6	3	7
17	7x49	m3_off	33.3333	100	4	3	9
18	8x50	m3_off	100	0	4	3	9
19	8x51	m3_off	0	0	4	2	9
20	8x53	m3_off	0	0	4	3	9
21	1x57	Shared	66.6667	50	5	5	9
22	I1x50	Shared	100	100	4	4	9
23	2x40	Shared	33.3333	100	4	5	9
24	2x42	Shared	100	100	5	5	8
25	2x50	Shared	33.3333	50	4	4	9
26	2x57	Shared	33.3333	0	5	4	9
27	E1x50	Shared	100	50	7	4	9
28	3x28	Shared	100	50	5	4	7
29	3x37	Shared	0	0	4	4	9
30	3x51	Shared	100	100	4	5	9
31	I2x53	Shared	66.6667	100	4	4	9
32	I2x57	Shared	100	100	5	5	9
33	4x57	Shared	100	100	5	7	9
34	E2	Shared	100	100	15	15	6
35	E2x52	Shared	100	50	4	4	8
36	5x47	Shared	100	100	6	6	9
37	6x44	Shared	66.6667	100	6	4	9
38	6x48	Shared	100	100	6	7	9
39	E3	Shared	100	100	7	6	6
40	7x39	Shared	100	100	7	5	8
41	7x42	Shared	100	100	7	7	9
42	7x45	Shared	100	50	5	4	9
43	7x53	Shared	66.6667	50	4	4	9
44	Lig	Shared	100	100	13	12	0
45	2x53	m3_on	0	0	3	4	9
46	2x56	m3_on	33.3333	0	3	4	9
47	3x46	m3_on	0	0	1	4	9
48	4x61	m3_on	0	0	3	4	9
49	5x36	m3_on	0	50	3	4	7
50	5x48	m3_on	0	50	3	5	8
51	5x58	m3_on	0	0	3	5	9
52	5x62	m3_on	0	0	1	5	8
53	5x66	m3_on	0	0	2	4	7
54	6x40	m3_on	0	0	3	4	9
55	6x49	m3_on	0	0	3	4	8
56	6x52	m3_on	0	100	3	4	9
57	6x59	m3_on	0	50	2	4	8
58	8x54	m3_on	0	50	3	4	9

Orange: nodes, hubs and links specific of m3_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m3_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	m3_off Recurrence	m3_on Recurrence	m3_off Hub1?	m3_on Hub1?	m3_off Hub2?	m3_on Hub2?	ConSurf1	ConSurf2
1	1x34	1x38	m3_off	28.8784	0	No	No	No	No	5	5
2	1x38	1x42	m3_off	34.6062	1.17444	No	No	No	No	5	7
3	1x42	7x39	m3_off	39.7306	2.33681	No	No	Yes	Yes	7	8
4	1x39	7x39	m3_off	14.8111	3.3584	Yes	No	Yes	Yes	8	8
5	2x61	7x39	m3_off	42.8796	0	Yes	No	Yes	Yes	8	8
6	2x60	7x39	m3_off	39.5983	0	Yes	No	Yes	Yes	8	8
7	2x60	3x28	m3_off	13.4474	4.08237	Yes	No	Yes	Yes	8	7
8	2x59	3x28	m3_off	20.1752	1.48413	No	No	Yes	Yes	8	7
9	2x551	2x59	m3_off	18.3321	0	Yes	No	No	No	6	8
10	2x55	2x551	m3_off	10.5711	2.40116	No	No	Yes	No	7	6
11	7x39	7x42	m3_off	67.9891	3.54342	Yes	Yes	Yes	Yes	8	9
12	1x50	2x50	m3_off	18.6048	7.55741	No	No	Yes	Yes	9	9
13	1x50	7x50	m3_off	12.6374	6.06122	No	No	No	No	9	9
14	7x49	7x53	m3_off	71.3861	0	Yes	No	Yes	Yes	9	9
15	2x43	7x53	m3_off	76.5435	0	No	No	Yes	Yes	9	9
16	2x40	2x43	m3_off	76.0063	0	Yes	Yes	No	No	9	9
17	2x40	8x50	m3_off	68.485	2.21212	Yes	Yes	Yes	No	9	9
18	8x50	8x54	m3_off	29.3247	0	Yes	No	No	Yes	9	9
19	8x50	I1x50	m3_off	15.9848	0.193058	Yes	No	Yes	Yes	9	9
20	3x37	Lig	m3_off	65.741	5.57053	Yes	Yes	Yes	Yes	9	0
21	3x37	4x53	m3_off	75.0889	4.5811	Yes	Yes	No	No	9	9
22	3x38	4x53	m3_off	73.7416	3.44689	No	No	No	No	9	9
23	3x38	4x50	m3_off	72.5762	2.30463	No	No	Yes	No	9	9
24	2x45	4x50	m3_off	70.4934	0	No	No	Yes	No	9	9
25	2x45	4x46	m3_off	100	3.63995	No	No	Yes	No	9	9
26	2x41	4x46	m3_off	39.4578	0	Yes	No	Yes	No	8	9
27	7x38	7x42	m3_off	45.8137	2.24028	Yes	No	Yes	Yes	7	9
28	3x32	7x42	m3_off	34.4905	0.19708	Yes	No	Yes	Yes	9	9
29	3x32	Lig	m3_off	58.9305	2.28854	Yes	No	Yes	Yes	9	0
30	2x50	3x39	m3_off	22.0101	1.52435	Yes	Yes	No	No	9	9
31	2x46	3x39	m3_off	36.7964	0	No	No	No	No	9	9
32	2x46	3x42	m3_off	35.3252	0	No	No	No	No	9	9
33	2x45	3x42	m3_off	34.7384	2.43333	No	No	No	No	9	9
34	1x57	2x41	m3_off	28.7296	2.41322	Yes	Yes	Yes	No	9	8
35	8x47	8x50	m3_off	26.5972	1.2951	No	No	Yes	No	9	9
36	2x42	4x46	m3_off	89.4041	6.02904	Yes	Yes	Yes	No	8	9
37	3x28	E1x50	m3_off	14.3731	8.60717	Yes	Yes	Yes	Yes	7	9
38	2x61	2x62	m3_off	23.1341	1.17444	Yes	No	No	No	8	6
39	2x62	2x66	m3_off	17.3733	0	No	No	No	No	6	7
40	3x28	3x29	m3_off	13.2408	0	Yes	Yes	Yes	No	7	8
41	3x29	E2x52	m3_off	10.1744	0	Yes	No	Yes	Yes	8	8
42	E2	E2x52	m3_off	17.4229	1.28705	Yes	Yes	Yes	Yes	6	8
43	3x33	7x38	m3_off	19.1917	0	Yes	No	Yes	No	9	7
44	3x33	E2x52	m3_off	26.217	8.87262	Yes	No	Yes	Yes	9	8
45	3x33	4x57	m3_off	14.7863	0.185014	Yes	No	Yes	Yes	9	9
46	3x30	4x62	m3_off	14.9516	0	No	No	No	No	8	8
47	6x44	6x48	m3_off	22.787	0.579174	Yes	Yes	Yes	Yes	9	9
48	3x40	6x44	m3_off	11.034	0.639504	No	No	Yes	Yes	9	9
49	3x37	3x41	m3_off	14.0838	1.15433	Yes	Yes	No	No	9	8
50	5x54	6x44	m3_off	26.6303	0	No	No	Yes	Yes	9	9
51	3x48	3x52	m3_off	12.3977	0	No	No	No	No	8	7
52	3x51	3x55	m3_off	15.6542	9.35527	Yes	Yes	No	No	9	8
53	3x51	5x61	m3_off	12.5548	1.38358	Yes	Yes	No	No	9	9
54	2x41	4x39	m3_off	21.6547	1.12617	Yes	No	No	No	8	7
55	4x39	4x40	m3_off	18.5057	0	No	No	No	No	7	6
56	4x38	4x40	m3_off	10.9017	1.2227	No	No	No	No	9	6
57	3x34	4x57	m3_off	19.4809	0	No	No	Yes	Yes	8	9
58	3x34	4x54	m3_off	16.2741	2.15581	No	No	No	No	8	5
59	5x39	E2	m3_off	15.117	1.06584	No	No	Yes	Yes	8	6
60	5x36	5x39	m3_off	11.9431	0.00804408	No	Yes	No	No	7	8
61	6x52	Lig	m3_off	23.1672	6.80932	No	Yes	Yes	Yes	9	0
62	5x48	6x52	m3_off	12.4886	2.53791	No	Yes	No	Yes	8	9
63	5x48	6x56	m3_off	24.2499	9.19841	No	Yes	No	No	8	7
64	5x41	6x56	m3_off	20.448	7.94755	No	No	No	No	7	7
65	5x47	5x51	m3_off	10.224	2.34485	Yes	Yes	No	No	9	8
66	5x47	6x49	m3_off	13.3399	9.3432	Yes	Yes	No	Yes	9	8
67	5x54	6x41	m3_off	21.8117	0	No	No	No	No	9	8
68	5x58	6x41	m3_off	16.4559	3.94562	No	Yes	No	No	9	8
69	5x58	5x59	m3_off	11.034	0	No	Yes	Yes	No	9	5
70	6x32	8x47	m3_off	22.7953	0	No	No	No	No	9	9
71	6x29	6x32	m3_off	18.704	0	No	No	No	No	7	9
72	6x29	6x30	m3_off	14.1251	0	No	No	No	No	7	9
73	6x27	6x30	m3_off	11.8109	0	No	No	No	No	6	9
74	6x40	7x49	m3_off	11.0422	0	No	Yes	Yes	No	9	9
75	6x40	7x52	m3_off	13.8772	3.6319	No	Yes	No	No	9	9
76	6x51	7x34	m3_off	26.06	0	No	No	Yes	No	9	5
77	7x34	E3	m3_off	18.6131	0	Yes	No	Yes	Yes	5	6
78	7x30	E3	m3_off	11.3315	3.89334	No	No	Yes	Yes	7	6
79	7x54	8x54	m3_off	13.8772	0	No	No	No	Yes	9	9
80	7x54	8x51	m3_off	11.6043	0	No	No	Yes	No	9	9
81	3x55	3x56	m3_off	12.5548	5.49813	No	No	No	No	8	8
82	1x28	1x31	m3_off	17.3733	0.0160882	No	No	No	No	4	7
83	1x31	1x34	m3_off	23.1341	0	No	No	No	No	7	5
84	1x28	1x30	m3_off	11.596	0	No	No	No	No	4	4
85	2x61	2x65	m3_off	15.0426	0	Yes	No	No	No	8	8
86	3x28	3x32	m3_off	31.0604	0	Yes	Yes	Yes	No	7	9
87	3x39	7x45	m3_off	28.5561	0	No	No	Yes	Yes	9	9
88	3x33	Lig	m3_off	14.4971	9.68105	Yes	No	Yes	Yes	9	0
89	6x51	Lig	m3_off	19.4727	2.35289	No	No	Yes	Yes	9	0
90	5x47	6x44	m3_off	14.4971	9.75747	Yes	Yes	Yes	Yes	9	9
91	3x37	4x57	m3_off	20.6463	1.25085	Yes	Yes	Yes	Yes	9	9
92	1x46	2x57	Shared	17.8114	15.0786	No	No	Yes	Yes	9	9
93	1x46	7x47	Shared	13.3813	10.7429	No	No	No	No	9	8
94	2x53	7x42	Shared	36.6063	13.2204	No	Yes	Yes	Yes	9	9
95	2x53	7x46	Shared	38.1189	19.2254	No	Yes	No	No	9	9
96	2x50	7x46	Shared	37.375	19.2374	Yes	Yes	No	No	9	9
97	2x50	7x49	Shared	27.432	22.2218	Yes	Yes	Yes	No	9	9
98	1x52	8x54	Shared	13.8772	11.495	No	No	No	Yes	8	9
99	1x57	2x40	Shared	36.5319	11.0888	Yes	Yes	Yes	Yes	9	9
100	2x60	7x38	Shared	35.8459	16.4059	Yes	No	Yes	No	8	7
101	7x38	Lig	Shared	57.4676	15.1229	Yes	No	Yes	Yes	7	0
102	2x42	3x49	Shared	76.8245	65.9333	Yes	Yes	Yes	No	8	9
103	4x57	E2	Shared	51.3183	25.2343	Yes	Yes	Yes	Yes	9	6
104	4x57	Lig	Shared	43.4581	37.5659	Yes	Yes	Yes	Yes	9	0
105	3x30	4x61	Shared	18.5718	14.8695	No	No	No	Yes	8	9
106	6x48	Lig	Shared	84.0565	57.7927	Yes	Yes	Yes	Yes	9	0
107	3x49	I2x53	Shared	56.2113	19.5592	Yes	No	Yes	Yes	9	9
108	3x52	I2x53	Shared	54.4425	24.627	No	No	Yes	Yes	7	9
109	3x51	3x52	Shared	39.6975	23.3841	Yes	Yes	No	No	9	7
110	5x47	6x48	Shared	21.7125	13.313	Yes	Yes	Yes	Yes	9	9
111	6x48	7x45	Shared	58.7817	63.4477	Yes	Yes	Yes	Yes	9	9
112	2x57	7x42	Shared	32.1927	17.4195	Yes	Yes	Yes	Yes	9	9
113	4x61	E2x52	Shared	17.2742	17.3833	No	Yes	Yes	Yes	9	8
114	7x45	7x49	Shared	68.3693	84.2336	Yes	Yes	Yes	No	9	9
115	6x44	7x45	Shared	30.1265	10.7871	Yes	Yes	Yes	Yes	9	9
116	5x47	5x48	Shared	15.7782	11.7725	Yes	Yes	No	Yes	9	8
117	6x47	7x43	m3_on	0	10.3648	Yes	No	No	No	9	8
118	6x47	7x45	m3_on	7.00058	10.2321	Yes	No	Yes	Yes	9	9
119	2x46	7x49	m3_on	0	100	No	No	Yes	No	9	9
120	2x46	3x43	m3_on	0	99.7587	No	No	No	No	9	9
121	3x43	7x53	m3_on	0	99.4852	No	No	Yes	Yes	9	9
122	3x46	7x53	m3_on	0	66.8785	No	Yes	Yes	Yes	9	9
123	2x42	3x46	m3_on	2.63658	71.4435	Yes	Yes	No	Yes	8	9
124	3x49	I2x57	m3_on	5.29796	45.7145	Yes	No	Yes	Yes	9	9
125	I2x54	I2x57	m3_on	0	42.9232	No	No	Yes	Yes	8	9
126	2x39	I2x54	m3_on	0	45.3284	No	No	No	No	9	8
127	2x39	2x40	m3_on	0	44.3631	No	No	Yes	Yes	9	9
128	2x40	I1x50	m3_on	0	31.0542	Yes	Yes	Yes	Yes	9	9
129	1x60	I1x50	m3_on	4.80205	27.921	No	No	Yes	Yes	8	9
130	1x60	8x53	m3_on	0.0413257	25.8416	No	No	Yes	No	8	9
131	1x56	8x53	m3_on	2.42995	18.8191	No	No	Yes	No	9	9
132	1x56	8x54	m3_on	0	17.6125	No	No	No	Yes	9	9
133	7x42	Lig	m3_on	0	18.9157	Yes	Yes	Yes	Yes	9	0
134	2x60	2x64	m3_on	2.62832	17.4235	Yes	No	No	No	8	8
135	2x64	7x35	m3_on	0.148773	16.2169	No	No	No	No	8	6
136	3x50	7x53	m3_on	0	14.4753	No	No	Yes	Yes	9	9
137	3x50	5x58	m3_on	0	19.7844	No	No	No	Yes	9	9
138	6x40	7x53	m3_on	4.96735	23.8145	No	Yes	Yes	Yes	9	9
139	5x58	6x40	m3_on	0	14.4592	No	Yes	No	Yes	9	9
140	5x58	6x37	m3_on	0	25.1257	No	Yes	No	No	9	9
141	5x62	6x37	m3_on	0	23.2112	No	Yes	No	No	8	9
142	5x62	5x66	m3_on	0	13.5583	No	Yes	No	Yes	8	7
143	7x31	7x35	m3_on	5.33928	15.0424	No	No	No	No	2	6
144	7x31	7x34	m3_on	0	13.8238	No	No	Yes	No	2	5
145	6x58	7x34	m3_on	2.3473	12.597	No	No	Yes	No	7	5
146	6x58	E3	m3_on	0	11.4709	No	No	Yes	Yes	7	6
147	1x52	8x58	m3_on	2.3473	10.2562	No	No	No	No	8	8
148	3x30	4x58	m3_on	0	12.8343	No	No	No	No	8	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	2x56	Shared	4.12667	5.42	1	1	2	2
2x53	7x42	Shared	4.83667	6.045	1	1	2	1
2x56	3x32	Shared	11.29	9.57	1	1	2	1
2x56	7x42	Shared	6.78333	3.815	1	1	2	1
2x57	7x39	Shared	6.20333	5.815	1	1	2	2
2x57	7x42	Shared	4.39	5.385	1	1	2	1
2x60	3x28	Shared	7.01667	4.51	1	0	2	2
2x60	7x38	Shared	17.5367	11.35	1	0	2	1
2x60	7x39	m3_off	4.34333	0	1	0	2	2
2x60	7x42	m3_off	6.53333	0	1	0	2	1
3x28	3x32	m3_off	4.84	0	1	0	2	1
3x32	7x38	m3_off	6.51667	0	1	1	1	1
3x32	7x42	Shared	11.1067	12.065	1	1	1	1
3x32	Lig	Shared	3.79333	9.665	1	1	1	0
3x33	4x57	Shared	12.22	16.005	1	1	1	1
3x33	E2x52	Shared	9.67	5.05	1	1	1	2
3x33	7x38	m3_off	3.64	0	1	1	1	1
3x33	Lig	Shared	17.8167	5.965	1	1	1	0
3x36	Lig	Shared	8.01667	7.22	0	0	1	0
3x37	4x53	Shared	8.94	8.94	1	1	1	2
3x37	4x57	Shared	7.91	7.345	1	1	1	1
3x37	Lig	Shared	3.81333	4.645	1	1	1	0
3x40	6x44	Shared	3.49333	9.18	0	1	2	2
4x57	E2	Shared	5.57667	4.005	1	1	1	2
4x57	Lig	Shared	4.11333	15.05	1	1	1	0
E2	E2	Shared	59.8833	34.895	1	1	2	2
E2	E2x52	Shared	16.0233	14.87	1	1	2	2
5x461	Lig	Shared	5.03	3.94	0	0	1	0
5x47	5x48	Shared	7.56667	8.77	1	1	2	2
5x47	6x44	Shared	4.64333	4.825	1	1	2	2
5x47	6x48	Shared	6.01333	6.015	1	1	2	1
5x47	6x52	Shared	27.3867	17.52	1	1	2	1
5x48	6x52	Shared	4.65	4.07	1	1	2	1
6x44	6x48	Shared	17.7033	6.015	1	1	2	1
6x44	7x45	Shared	4.83	4.83	1	1	2	2
6x47	6x48	Shared	4.85	5.455	1	1	2	1
6x47	7x45	Shared	8.28667	5.85	1	1	2	2
6x48	7x41	Shared	13.0633	11.755	1	1	1	1
6x48	7x45	Shared	6.02667	6.78	1	1	1	2
6x48	Lig	Shared	13.66	10.85	1	1	1	0
6x51	7x34	m3_off	8.03667	0	1	1	1	2
6x51	7x38	m3_off	8.60667	0	1	1	1	1
6x51	Lig	Shared	10.7933	12.67	1	1	1	0
6x52	Lig	Shared	9.41	5.17	1	1	1	0
7x38	7x42	Shared	8.93667	7.445	1	1	1	1
7x38	Lig	Shared	16.5933	13.695	1	1	1	0
7x39	7x42	Shared	7.71667	4.82	1	1	2	1
7x41	Lig	Shared	6.44667	7.715	1	1	1	0
5x43	Lig	m3_off	3.11	0	0	0	1	0
3x37	3x41	Shared	2.8	3.505	1	1	1	2
5x44	Lig	m3_off	2.35667	0	0	0	1	0
3x34	4x57	m3_off	1.63667	0	0	0	2	1
2x56	3x28	m3_on	0	3.705	1	1	2	2
3x40	6x48	m3_on	0	4.9	0	1	2	1
4x56	4x57	m3_on	0	3.985	0	0	2	1
4x57	E2x52	m3_on	0	4.11	1	1	1	2
4x57	5x43	m3_on	0	7.885	1	1	1	1
6x51	6x52	m3_on	0	5.815	1	1	1	1
6x51	6x55	m3_on	0	5.05	1	1	1	2
7x42	Lig	m3_on	0	5.61	1	1	1	0
5x44	5x48	m3_on	0	2	0	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	m3_off	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl Scopolamine 5ZHP-M₃-PubChem 134828589
	m3_on	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2

Network Difference
Value	m3_off	m3_on
I_min	3.31333	3.695
Number of Linked Nodes	259	260
Number of Specific Nodes	5 (1.93%)	6 (2.31%)
Number of Shared Nodes	254 (98.07%)	254 (97.69%)
Number of Links	304	292
Number of Specific Links	114 (37.50%)	102 (34.93%)
Number of Shared Links	190 (62.50%)	190 (65.07%)
Number of Hubs	44	38
Number of Specific Hubs	20 (45.45%)	14 (36.84%)
Number of Shared Hubs	24 (54.55%)	24 (63.16%)
Average % Shared Neighbours (Jaccard)	48.33
Average % Shared Neighbours (Otsuka)	57.97
Average % Shared Neighbours (Overlap Coefficient)	68.41
Average % Shared Cliques (k3-6)	56.82
Graphlets Similarity	0.629542

Paths Difference
Value	m3_off	m3_on
Number Of Nodes in MetaPath	102	57
Specific Nodes in MetaPath	65 (63.73%)	20 (35.09%)
Shared Nodes in MetaPath	254 (98.07%)	254 (98.07%)
Number Of Links MetaPath	116	57
Specific Links in MetaPath	91 (78.45%)	32 (56.14%)
Shared Links in MetaPath	190 (62.50%)	190 (62.50%)
Number of Shortest Paths	50766	44751
Length Of Smallest Path	3	3
Average Path Length	11.2015	14.0829
Length of Longest Path	26	38
Minimum Path Strength	0.506667	0.63
Average Path Strength	6.39774	6.87966
Maximum Path Strength	18.9517	15.01
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.912809	0.919936
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	5.26316	3.84615
Average % Of Corr. Nodes	48.8737	47.2586
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	53.7025	46.3511
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download m3_off_on.zip<

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